Systematic Reviews最新文献

{"title":"Utilization of maternal healthcare services in low- and middle-income countries: a systematic review and meta-analysis.","authors":"Abdul Baten, Raaj Kishore Biswas, Evie Kendal, Jahar Bhowmik","doi":"10.1186/s13643-025-02832-0","DOIUrl":"10.1186/s13643-025-02832-0","url":null,"abstract":"<p><strong>Background: </strong>Maternal mortality is a critical public health issue, especially in low- and middle-income countries (LMICs). Maternal healthcare services (MHS), including antenatal care (ANC) visits, skilled birth attendants (SBA), institutional delivery (ID), and postnatal care (PNC), are crucial policy priorities to address maternal mortality and improve pregnancy outcomes. This systematic review and meta-analysis aimed to provide a comprehensive, quantitative analysis of MHS utilization among women in LMICs.</p><p><strong>Methods: </strong>We conducted a comprehensive search on PubMed, Scopus, Web of Science, CINAHL, and SocINDEX to gather relevant studies on the utilization of MHS in LMICs conducted between January 2015 and December 2024. These were then synthesized both quantitatively and qualitatively and random-effect models were employed to obtain pooled estimates.</p><p><strong>Results: </strong>A total of 145 studies included in this review. Coverage of at least one ANC visit (ANC1), at least four ANC visits (ANC4), SBA, ID and PNC were reported in 66, 108, 42, 63, and 37 studies respectively and for these studies pooled prevalences of ANC1, ANC4, SBA, ID, and PNC were found 85.0% (95% CI 81.2-88.1%), 50.8% (95% CI 46.4-55.2%), 65.6% (95% CI 58.7-71.9%), 66.9% (95% CI 60.3-72.9%), and 48.9% (95% CI 41.7-56.2%), respectively, with high heterogeneity among the studies (I² > 99.0%). Results obtained from the sub-group analysis revealed that the prevalence of MHS indicators was higher in the South and Southeast Asia (SSEA) region compared to Sub-Saharan Africa (SSA), except for ID, e.g., SBA prevalence in SSEA was 70.1% (95% CI 60.4-78.3%) whereas for SSA it was 64.0% (95% CI 53.3-73.6%). The prevalence of all MHS indicators was higher for studies with primary data than those with secondary data, except for ANC4 and PNC. Overall, associations were reported between MHS utilization and women's age, education level, household socioeconomic status, place of residence, decision-making power, and exposure to mass media.</p><p><strong>Conclusion: </strong>High heterogeneity among studies infer possible disparities in MHS utilization at both global and national levels. Hence, it is crucial for policies to prioritize enhancing effective coverage, narrowing disparities, and improving care quality in alignment with the Sustainable Development Goals.</p><p><strong>Systematic review registration: </strong>PROSPERO CRD42023401745.</p>","PeriodicalId":22162,"journal":{"name":"Systematic Reviews","volume":"14 1","pages":"88"},"PeriodicalIF":6.3,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12004674/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144035738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of acupuncture combined with Western medicine on vertebrobasilar artery hemodynamics and efficacy in patients with CV: a systematic review and meta-analysis.","authors":"Ruiyong Yang, Meiting Liu, Chenglin Tang, Shanshan Wang","doi":"10.1186/s13643-025-02810-6","DOIUrl":"10.1186/s13643-025-02810-6","url":null,"abstract":"<p><strong>Objective: </strong>To systematically evaluate the effect of acupuncture combined with Western medicine on vertebrobasilar artery hemodynamics and its clinical efficacy in patients with cervical vertigo. To provide a reliable evidence-based medical basis for the clinical treatment of CV.</p><p><strong>Methods: </strong>This systematic review and meta-analysis will be reported in agreement with the Meta-Analyses (PRISMA2020) statement. MEDLINE, Embase, Web of Science, the Cochrane Library, CNKI, VIP, Wan Fang, and China Biology Medicine Disc (CBM) were searched until August 20, 2024. The quality of the included studies was assessed using the Cochrane Collaboration's tool for assessing the risk of bias, and the data were analyzed using Revman5.4, StataMP 18, and TSA0.9.5.10Beta software.</p><p><strong>Results: </strong>A total of 7 randomized controlled trials involving 714 patients were included. The meta-analysis results showed that acupuncture combined with Western medication was superior to simple Western medication in improving the blood flow velocity of the left vertebral artery, right vertebral artery, and basilar artery in patients with CV, improving the symptoms of cervical vertigo and improving its function and clinical efficacy. TSA analysis results again confirmed the robustness of the results of this meta-analysis.</p><p><strong>Conclusion: </strong>Acupuncture combined with Western medicine has measurable benefits in improving vertebrobasilar hemodynamics and clinical efficacy in patients with CV, with certain safety. However, there are still methodological defects such as small sample size, different acupuncture treatment methods, and information on minimal clinically relevant differences is missing. In the future, RCTs with larger sample sizes and longer observations are still needed to further verify the efficacy of acupuncture combined with Western medicine, and an updated meta-analysis can be conducted to analyze the efficacy of acupuncture combined with Western medicine in the treatment of CV.</p><p><strong>Systematic review registration: </strong>PROSPERO CRD42024592131.</p>","PeriodicalId":22162,"journal":{"name":"Systematic Reviews","volume":"14 1","pages":"87"},"PeriodicalIF":6.3,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11998407/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144064625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Understanding intergenerational dynamics and social support's impact on health and well-being of older adults in South Asia: a scoping review.","authors":"Selim Jahangir, Divya Sussana Patil, Jagriti Gangopadhyay, Tobias C Vogt","doi":"10.1186/s13643-025-02833-z","DOIUrl":"10.1186/s13643-025-02833-z","url":null,"abstract":"<p><strong>Background: </strong>Traditionally, family members take care of older relatives in South Asian societies, and there is a strong reciprocal filial obligation through intergenerational family relations. The changing family structure, living arrangements, and out-migration have led to subsequent changes in reciprocal family support that influence the health and well-being of older adults. This scoping review aims to (1) map the evidence and prevailing motivations for family support including financial, instrumental, and emotional support that affect the health and well-being of older adults and (2) identify the research gaps in the academic scholarship available on motivation for family support to older adults given the changing demographic and societal dynamics in the South Asian societies.</p><p><strong>Methods: </strong>We followed the Preferred Reporting Items for Systematic reviews and Meta-Analyses extension for Scoping Review (PRISMA-ScR) guidelines. Electronic databases PubMed, Embase, Scopus, and ProQuest were searched, and Google Scholar was used to identify grey literature. The screening of titles, abstracts, and full texts included 22 studies for analysis.</p><p><strong>Results: </strong>The included studies covered health indicators such as stress and/or depression, loneliness/isolation, loss of support/neglect, and level of satisfaction to illustrate well-being of older adults. The findings revealed that adult children recognised filial duties and responsibilities to provide care to older parents, whereas older parents provide cultural upbringing and care to grandchildren. Reciprocal care exchange, cultural expectations, and intergenerational transfers motivated adult children to be primary caregivers to their older parents. Intergenerational family care such as financial, instrumental, and emotional support is associated with a higher level of life satisfaction and lower level of depression and thus reported better health and well-being among older adults.</p><p><strong>Conclusion: </strong>Although intergenerational support is still a significant factor in determining the well-being of older adults in South Asia, this study shows the complexity of intergenerational ambivalence, where caregiving responsibilities lead to both emotional stress and a sense of obligation. Additionally, out-migration of adult children and subsequent physical absence also increase psychological distress and loneliness of older adults. This emphasises the need for policies that address both the emotional and financial aspects of elder care. The Madrid International Plan of Action on Ageing (MIPAA) policies can be adopted to ensure friendly and supportive environments and emphasise the health and well-being of older adults in developing countries. MIPAA highlights the importance of policies that promote intergenerational solidarity, active ageing, and social protection for older individuals.</p>","PeriodicalId":22162,"journal":{"name":"Systematic Reviews","volume":"14 1","pages":"86"},"PeriodicalIF":6.3,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11987332/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144015695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Practical methods for incorporating summary time-to-event data into meta-analysis: updated guidance.","authors":"Jayne F Tierney, Sarah Burdett, David J Fisher","doi":"10.1186/s13643-025-02752-z","DOIUrl":"10.1186/s13643-025-02752-z","url":null,"abstract":"<p><p>Our previous guide to estimating hazard ratios (HRs) from published summary (aggregate) data has become very widely used, but many still have difficulties knowing when and how to apply the methods. Informed by our increased experience of applying them across a range of settings, the queries we have received and results of a survey of Cochrane editors on the methods, we have updated the guidance comprehensively. Previously, we described a range of scenarios for deriving a HR and logrank variance (V) from published time-to-event analyses. They are incorporated in this update, together with clarification of ambiguities and additional scenarios. We also provide further guidance on extracting and using data from publications and Kaplan-Meier (KM) curves, raise some of the challenges, and discuss recent alternatives to the \"Parmar\" KM methods. A new calculations spreadsheet will perform all possible calculations given the data that are entered and includes new features to enhance the user experience. This updated guidance and associated spreadsheet represent valuable additional tools for those conducting meta-analyses based on published, summary, time-to-event data.</p>","PeriodicalId":22162,"journal":{"name":"Systematic Reviews","volume":"14 1","pages":"84"},"PeriodicalIF":6.3,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11984287/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144064740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Publication bias in prevalence studies should not be ignored.","authors":"Masoud Mohammadi","doi":"10.1186/s13643-025-02845-9","DOIUrl":"https://doi.org/10.1186/s13643-025-02845-9","url":null,"abstract":"","PeriodicalId":22162,"journal":{"name":"Systematic Reviews","volume":"14 1","pages":"85"},"PeriodicalIF":6.3,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11983934/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144062275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Developing a core outcome set for acetabular fractures: a systematic review (part I).","authors":"Denise Schulz, Catharina Gaeth, Martin C Jordan, Steven C Herath, Christopher Spering, Dan Bieler, Joachim Windolf, Anne Neubert","doi":"10.1186/s13643-025-02824-0","DOIUrl":"10.1186/s13643-025-02824-0","url":null,"abstract":"<p><strong>Background: </strong>There are indications that clinical studies investigating the surgical treatment of acetabular fractures assess different outcomes. This heterogeneity reduces the comparability of study results and, thus, limits the knowledge generated from research. Core outcome sets (COS) contain a minimum set of outcomes that should be measured in studies investigating a specific disease or injury. A COS for surgically treated acetabular fractures does not yet exist. Therefore, the aim of this study is to identify the reported outcomes in studies investigating the surgical treatment of acetabular fractures.</p><p><strong>Methods: </strong>Studies including skeletally mature individuals (≥ 16 years) with isolated acetabular fractures treated surgically were included. Studies with polytrauma patients, pathological fractures, additional pelvic fractures, exclusively non-surgical treatment, or juvenile individuals were excluded. Three databases and two clinical trial registries were searched on 15 November 2022. The identified outcomes were grouped and subsequently categorized according to the Core Outcome Measures in Effectiveness Trials Guidelines.</p><p><strong>Results: </strong>A total of 193 studies were included, which reported a cumulative total of 2581 outcomes. After grouping, 266 unique outcomes were identified. No outcome was examined in all studies. Pain, ability to walk independently, range of motion, quality of reduction, and heterotopic ossification were the most reported unique outcomes and assessed in at least 60% of included studies. A total of 105 outcomes were only assessed in one of the included studies. Outcomes of all five core areas and 25 outcome domains of the Core Outcome Measures in Effectiveness Trials taxonomy were examined. Furthermore, outcomes were named and defined differently, measured at different time points, and assessed using a variety of measurement instruments.</p><p><strong>Conclusion: </strong>Overall, this systematic review shows that a wide range of outcomes are measured in studies examining surgical treatment of acetabular fractures. The results of this systematic review will be used in a subsequent study to develop the COS for surgically treated acetabular fractures by using the Delphi method.</p><p><strong>Systematic review registration: </strong>PROSPERO: CRD42022357644; COMET: 2123.</p>","PeriodicalId":22162,"journal":{"name":"Systematic Reviews","volume":"14 1","pages":"83"},"PeriodicalIF":6.3,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11983908/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144050064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Off-label use of sodium cantharidinate and vitamin B6 injection in cancer: a protocol for a systematic review and meta-analysis.","authors":"Wenzhen Jin, Yibin Zhang, Shu Pang, Dongdong Yao, Yiwen Huang","doi":"10.1186/s13643-025-02826-y","DOIUrl":"10.1186/s13643-025-02826-y","url":null,"abstract":"<p><strong>Background: </strong>In China, sodium cantharidinate/vitamin B6 (SC/VB6) injection has been approved since 2002 for the treatment of lung cancer and primary liver cancer. In addition to these authorized indications, clinical application of SC/VB6 is also common in various other types of cancer. However, there is a lack of comprehensive understanding on this topic. Thus, this systematic review and meta-analysis aims to consolidate evidence regarding the efficacy and safety of off-label use of SC/VB6 in oncology.</p><p><strong>Methods: </strong>International databases including PubMed, Embase, Cochrane Library, Web of Science, and CINAHL Plus, as well as Chinese databases including China National Knowledge Infrastructure (CNKI), Chinese Biomedical Literature Database (CBM), and Wanfang, will be searched from the inception to 31 December 2024. Comparative studies that evaluated the add-on effect of SC/VB6 to conventional cancer treatments against the use of conventional treatments alone will be considered in the scope of this review. The primary outcomes are objective response rate and performance status. Secondary outcomes are disease control rate (DCR), progression-free survival (PFS), disease-free survival (DFS), overall survival (OS), and adverse events (AEs). Depending on heterogeneity, data will be synthesized using either the Mantel-Haenszel fixed-effect or the DerSimonian and Laird random-effect model. Subgroup analyses will be conducted for the following variables: type of cancer, study design, SC/VB6 dosage, treatment duration, and combined therapies, provided that each subgroup contains at least two studies. Sensitivity analyses will be performed on efficacy outcomes. The Grading of Recommendations Assessment, Development, and Evaluation (GRADE) will be utilized to appraise the overall quality of evidence.</p><p><strong>Discussion: </strong>This review will encompass both randomized controlled trials (RCTs) and cohort studies, thereby enabling us to synthesize and assess evidence across experimental and real-world observational settings. Our findings will contribute to a better understanding on the benefit-risk profile regarding the off-label use of SC/VB6 in oncology, guiding the trajectory of future research, and offering a robust scientific foundation to inform clinical and regulatory decision-making process.</p><p><strong>Systematic review registration: </strong>PROSPERO CRD42024504977.</p>","PeriodicalId":22162,"journal":{"name":"Systematic Reviews","volume":"14 1","pages":"82"},"PeriodicalIF":6.3,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11984136/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144043400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthetic lethality in cancer: a protocol for scoping review of gene interactions from synthetic lethal screens and functional studies.","authors":"Raashi Chauhan, Rama Rao Damerla, Vijay Shree Dhyani","doi":"10.1186/s13643-025-02814-2","DOIUrl":"10.1186/s13643-025-02814-2","url":null,"abstract":"<p><strong>Background: </strong>Two genes are synthetically lethal if loss of function of either one of the two genes does not result in cell death, whereas loss of function of both genes together results in being detrimental to cell survival. This concept has been the basis for developing personalized, precision treatments, which can selectively damage tumor cells and minimize toxicity to normal tissues. Tumor cells often harbor mutations in genes involved in DNA repair pathways, forcing them to switch to alternative repair pathways, leading to chemotherapeutic resistance. These interactions, if targeted, could be synthetically lethal. We aimed to summarize synthetically lethal gene pairs that could be utilized to selectively target cancer cells and minimize side effects on normal tissues. The objective of this review is to study druggable synthetically lethal gene pairs for targeted cancer therapy that have been identified through various genetic screens and functional studies.</p><p><strong>Methods: </strong>A systematic literature search will be conducted to extract synthetically lethal gene pairs that can be specifically targeted to cancer cells. Owing to the relatively recent research pertaining to this field, the literature search will incorporate data from 1956. The search will be conducted on PubMed, Web of Science, Embase, and Scopus. The narrative approach will guide the analysis and synthesis of the results.</p><p><strong>Discussion: </strong>This review highlights scientific articles that report druggable synthetically lethal gene pairs by testing the efficacy of targeted inhibitors in clonogenic assays. These include research studies that identify synthetically lethal gene pairs detected through CRISPR screens by knocking out one or two genes within the same cell and testing the potency of inhibitors to specifically kill malignant cells.</p><p><strong>Systematic review registration: </strong>https://doi.org/10.17605/OSF.IO/5BCW6 .</p>","PeriodicalId":22162,"journal":{"name":"Systematic Reviews","volume":"14 1","pages":"81"},"PeriodicalIF":6.3,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11978169/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143812453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Manual acupuncture enhanced therapeutic efficacy in vascular dementia rat model: systematic review and network meta-analysis.","authors":"Yuanyu Song, Yinghua Chen, Junfeng Li, Wei Sun, Fangfang Jin","doi":"10.1186/s13643-025-02821-3","DOIUrl":"10.1186/s13643-025-02821-3","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to systematically evaluate the efficacy of electroacupuncture and manual acupuncture for treating vascular dementia and to determine the optimal acupuncture point combination scheme for efficacy.</p><p><strong>Methods: </strong>The PubMed, Embase, Web of Science, Cochrane, CNKI, VIP, and Wanfang electronic databases were searched up to July 2024 to identify relevant randomized controlled trials. RevMan 5.4 software and Addis software were used to assess the risk of bias for each study, determine subgroup classifications, and conduct meta-analyses.</p><p><strong>Results: </strong>A total of 29 RCTs involving 659 animals were ultimately included. The meta-analysis results revealed that acupuncture treatment had a significant effect compared with the vascular dementia model group [mean difference (MD) = - 21.68, 95% confidence interval (CI) (- 25.77, - 17.59), P < 0.00001]. Manual acupuncture demonstrated better efficacy than electroacupuncture did [MD = - 0.42, 95% CI (- 12.72, 12.27)]. Among the different acupuncture point combinations, the Baihui (GV20) + Dazhui (GV14) combination yielded the best efficacy [MD = - 23.03, 95% CI (- 30.02, - 16.04), P < 0.00001]. Compared with other acupuncture protocols, the experiment conducted by Caiyu Peng et al. exhibited superior efficacy [MD = - 24.96, 95% CI (- 92.68, - 40.76)].</p><p><strong>Conclusion: </strong>Acupuncture significantly improves cognitive function in rats with vascular dementia. Manual acupuncture is more effective than electroacupuncture. Among the different acupuncture point combinations, manual acupuncture at GV20 and GV14 yields the best results. Compared with other acupuncture protocols, the best efficacy was observed when the two-vessel occlusion (2VO) model was used in 230 ± 10 g SD rats; when the Mingmen (GV4), Dazhui (GV14), Fengfu (GV16), Baihui (GV20), Shenting (GV24), Shuigou (GV26), Neiguan (PC6), Dalin (PC7), and Laogong (PC8) acupoints were selected; and when manual acupuncture with reinforcing and reducing methods was used for 30 min per day for 14 days.</p><p><strong>Systematic review registration: </strong>PROSPERO CRD42024551402.</p>","PeriodicalId":22162,"journal":{"name":"Systematic Reviews","volume":"14 1","pages":"80"},"PeriodicalIF":6.3,"publicationDate":"2025-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11971794/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143789204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Involving adolescents in evidence syntheses: an umbrella review.","authors":"Azza Warraitch, Matylda Sulowska, Ciara Wacker, Maria Lee, Delali Bruce, Joshua Hernon, Qusai Khraisha, Kristin Hadfield","doi":"10.1186/s13643-025-02815-1","DOIUrl":"10.1186/s13643-025-02815-1","url":null,"abstract":"<p><strong>Background: </strong>Stakeholder involvement in evidence syntheses has the potential to enhance the quality and relevance of reviews. However, adolescents rarely participate in evidence synthesis, mainly because their role and influence in shaping the synthesis process relating to health outcomes are poorly understood. To fully unlock the potential of evidence syntheses for adolescent health, it is crucial to understand how adolescents can contribute at various stages of the review process and how their involvement can influence outcomes.</p><p><strong>Methods: </strong>To achieve this, we conducted an umbrella review examining adolescent involvement in reviews related to adolescent health research, complemented by a case study that highlights how adolescents were engaged at various stages of this review. We ran a search across 11 databases, screened reference lists and 12 journals, and consulted experts in youth involvement.</p><p><strong>Results: </strong>We found only 10 reviews which involved adolescents. In those reviews, adolescents were engaged at almost every stage of the review process, with most involvement centred around interpreting findings or co-authoring the final reports. While adolescent participation was often consultative, there were examples of more collaborative involvement using a wide range of methods, even at technical stages like study selection and data analysis. However, reviews did not report on the impacts or benefits of adolescent involvement in evidence syntheses.</p><p><strong>Conclusion: </strong>To maximise the impact of adolescent involvement, we call for engagement of adolescents throughout the review process and the adoption of frameworks to ensure transparency and consistency in reporting.</p><p><strong>Systematic review registration: </strong>PROSPERO CRD42021287467.</p>","PeriodicalId":22162,"journal":{"name":"Systematic Reviews","volume":"14 1","pages":"79"},"PeriodicalIF":6.3,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11969981/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143789171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}