Systematic Reviews最新文献

{"title":"Comparative outcomes of human acellular dermal matrices in breast reconstruction: a systematic review and meta-analysis framework.","authors":"Yousef Tanas, Grace Gasper, Julie Tanas, Sarya Swed, Gioacchino De Sario Velasquez","doi":"10.1186/s13643-025-02915-y","DOIUrl":"10.1186/s13643-025-02915-y","url":null,"abstract":"<p><strong>Background: </strong>Acellular dermal matrices (ADMs) have become popularly used in implant-based breast reconstruction (IBBR) due to their potential to decrease the risk of implant complications such as capsular contracture and malposition. AlloDerm and DermACELL are two of the most commonly used human ADMs, each processed differently to enhance sterility and biocompatibility. Despite their widespread use, the comparative effectiveness and safety of these ADMs remain debatable among plastic surgeons, with conflicting evidence in the literature regarding their complication profiles. This systematic review and meta-analysis aims to evaluate the clinical outcomes associated with AlloDerm versus DermACELL in breast reconstruction.</p><p><strong>Methods: </strong>This review will follow the methodological guidance of the Cochrane Handbook for Systematic Reviews of Interventions. The database search will be conducted using MEDLINE (PubMed), Scopus, Web of Science, Cochrane Central Register of Controlled Trials, Cochrane Database of Systematic Reviews, and Clinicaltrials.org targeting studies from inception to search date. Studies will be screened using inclusion and exclusion criteria and data extracted into a spreadsheet. Screening, extraction, and risk-of-bias assessments will be performed independently by two reviewers and discrepancies resolved by a third independent reviewer. Primary outcomes include complication rates (e.g., capsular contracture, infection, implant malposition), patient-reported satisfaction (BREAST-Q), and drain time. Data analysis and meta-analysis will be performed using Microsoft Excel and Review Manager 5.4 software. Heterogeneity will be assessed using the I² statistic. A random-effects model will be applied in cases of significant heterogeneity followed by a sensitivity analysis. This review will be reported in accordance with the PRISMA 2020 checklist.</p><p><strong>Discussion: </strong>With the increasing use of ADMs in IBBR, it is important that surgeons have adequate evidence available to assist operative decision-making. This meta-analysis will help surgeons determine whether one ADM is better than the other. This could potentially minimize the risk of patient complications, improve patient satisfaction, and decrease unnecessary hospital readmissions or reoperations due to avoidable complications, thereby decreasing healthcare costs.</p><p><strong>Systematic review registration: </strong>PROSPERO CRD42024542928.</p>","PeriodicalId":22162,"journal":{"name":"Systematic Reviews","volume":"14 1","pages":"157"},"PeriodicalIF":3.9,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12308944/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144754360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effects of Gegen Qinlian decoction and its main constituents on glucolipid metabolic disorders in diabetes: an overview of systematic reviews and meta-analysis.","authors":"Chongxiang Xue, Ying Chen, Cheng Tang, Linhua Zhao, Xiaolin Tong, Han Wang","doi":"10.1186/s13643-025-02914-z","DOIUrl":"10.1186/s13643-025-02914-z","url":null,"abstract":"<p><p>Currently, an increasing number of individuals diagnosed with diabetes mellitus (DM) are opting for combined functional substances in edible plant products, like herbal prescription or traditional Chinese medicine (TCM), to enhance the efficacy of blood glucose and lipid profile control. Among various TCM-included treatments available, Gegen Qinlian decoction (GQD) is frequently utilized. Nevertheless, the efficacy and safety of GQD and its main constituents (berberine, puerarin, etc.) in managing glucolipid metabolic disorders (GLMD) in DM remain under considerable debate. This overview aims to provide a concise summary of the key findings from systematic review and meta-analysis (SRMAs) on GQD and its main constituents for GLMD in DM, while also assessing the methodological quality of these reviews. A comprehensive search of online databases was conducted with no language restrictions, covering the period from inception to February 20th, 2025. The methodological quality, risk of bias, and strength of evidence of those included SRMAs were accessed. Overlapping randomized controlled trials (RCTs) were excluded, and the results of included meta-analysis were summarized. After screening, 35 studies matching the inclusion criteria were identified. The current evidence indicated that GQD, berberine, and puerarin appeared to be effective in improving the anti-diabetes role. As for blood lipid profile, it is indicated that GQD and berberine intervention could effectively reduce total cholesterol (TC), total triglycerides (TG), low-density lipoprotein (LDL-c) and increase high-density lipoprotein (HDL-c). Consequently, further high-quality primary studies are imperative to establish a more conclusive understanding of GQD and its main constituents for GLMD in DM.</p>","PeriodicalId":22162,"journal":{"name":"Systematic Reviews","volume":"14 1","pages":"158"},"PeriodicalIF":3.9,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12308923/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144754361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative efficacy of conservative interventions for adolescent idiopathic scoliosis: a systematic review and network meta-analysis of randomized controlled trials.","authors":"Jun Ren, Shoujian Wang, Miaoxiu Li, Xin Zhou, Ya Wen, Zonglin Wen, Jiannan Lin, Lingjun Kong, Min Fang","doi":"10.1186/s13643-025-02893-1","DOIUrl":"10.1186/s13643-025-02893-1","url":null,"abstract":"<p><strong>Background: </strong>Adolescent idiopathic scoliosis (AIS) is a prevalent spinal disorder, and the efficacy of conservative interventions for AIS remains unclear. This study aimed to identify the comparative efficacy of all available conservative interventions for AIS.</p><p><strong>Methods: </strong>Nine databases were searched from their inception to February 2024 for randomized controlled trials comparing conservative interventions for AIS. Paired reviewers independently selected studies, assessed risk of bias, and assessed certainty of the evidence. Pairwise meta-analyses were performed by DerSimonian-Laird random-effects model. Network meta-analysis within the frequentist framework was conducted by R package netmeta, and network plots were generated by the network plot command in Stata.</p><p><strong>Results: </strong>We identified 3903 citations, of which 54 trials including 3984 participants were included in our review. All subsequent estimates refer to the comparison with minimal interventions. Brace plus physiotherapeutic scoliosis-specific exercises (PSSE, mean difference (MD): 4.80, 95% confidence interval (CI): 0.56 to 9.04, moderate certainty), manual therapy plus PSSE (MD: 5.26, 95% CI: 1.09 to 9.43, moderate certainty), and manual therapy plus mind-body exercise (MD: 5.14, 95% CI: 1.25 to 9.04, moderate certainty) could be intermediately effective in improving Cobb angle of patients with AIS at post-interventions. Although brace alone (MD: 1.53, 95% CI: 1.09 to 2.14, high certainty) could be the intermediate effective intervention in preventing scoliosis progression, moderate to high certainty evidence showed that brace alone and PSSE alone probably have little or no difference in improving Cobb angle, function, mental health, self-image, angle of trunk rotation (ATR), or satisfaction of patients with AIS compared to minimal interventions. There was no evidence on the follow-up effects of conservative interventions for AIS. We did not identify serious adverse events for any included conservative interventions.</p><p><strong>Conclusions: </strong>Brace plus PSSE, manual therapy plus PSSE, and manual therapy plus mind-body exercise could provide short-term effects in improving Cobb angle of patients with AIS. The evidence of brace alone and PSSE alone for managing AIS is still not robust. Our findings are useful for decision-making in clinical practice, as we presented the most comprehensive evidence regarding all available conservative interventions for AIS.</p><p><strong>Systematic review registration: </strong>PROSPERO CRD42024521298.</p>","PeriodicalId":22162,"journal":{"name":"Systematic Reviews","volume":"14 1","pages":"156"},"PeriodicalIF":3.9,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12309149/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144754359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetic testing for diagnosing neurodevelopmental disorders and epilepsy: a systematic review and meta-analysis.","authors":"Yu-Ming Chang, Yen-Ta Huang, Pei-Chun Lai","doi":"10.1186/s13643-025-02896-y","DOIUrl":"10.1186/s13643-025-02896-y","url":null,"abstract":"<p><strong>Background: </strong>Identifying the genetic causes of neurodevelopmental disorders (NDDs) and epilepsy is crucial for effective treatment and genetic counseling. Our objective was to determine the diagnostic yield of chromosomal microarray (CMA) and next-generation sequencing (NGS) methods-including targeted sequencing (TS), whole-exome sequencing (WES), and whole-genome sequencing (WGS)-in individuals with NDDs or epilepsy.</p><p><strong>Methods: </strong>We systematically searched PubMed, Embase, and the Cochrane Library through August 31, 2024. Two reviewers independently screened studies and extracted data. We included studies with ≥ 10 patients (probands) diagnosed with an NDD or epilepsy who underwent CMA, TS, WES, WGS, or WES reanalysis. Methodological quality was assessed using the Newcastle-Ottawa Scale (NOS). Random-effects meta-analysis was performed to pool diagnostic yield percentages. Subgroup analyses were conducted by test modality, disorder subtype, and clinical features.</p><p><strong>Results: </strong>A total of 416 studies (124,937 participants) met inclusion criteria. Pooled analysis showed significantly higher diagnostic yields with NGS methods compared to CMA (31.1% vs 14.8% in NDD cohorts; 28.7% vs 13.3% in epilepsy cohorts). Within NGS, WES had a higher yield than targeted gene panels (35.3% vs. 23.2% for NDDs; 34.2% vs. 24.0% for epilepsy). Diagnostic yields increased over time in more recent studies. Patients with certain clinical features had particularly high yields: NDDs with dysmorphic features (54.7%), syndromic presentations (37.6%), or co-occurring epilepsy (35.6%), and epilepsy with early onset (32.3%), epileptic encephalopathy (34.7%), or drug-resistant seizures (25.4%). Quality assessment using NOS revealed that the majority of included studies were of good to very good methodological quality.</p><p><strong>Conclusions: </strong>Despite substantial between-study heterogeneity and variability in study designs that may limit the certainty of our pooled estimates, and potential publication bias, our results demonstrate that NGS-based tests-particularly WES and WGS-provide markedly higher diagnostic yields in patients with NDDs or epilepsy compared to CMA, supporting their use as first-line genetic tests. Patients with dysmorphism, syndromic NDD, early-onset or refractory epilepsy, and epileptic encephalopathy achieve above-average diagnostic yields, highlighting the value of comprehensive genetic testing in these subgroups.</p><p><strong>Systematic review registration: </strong>PROSPERO CRD42024555664.</p>","PeriodicalId":22162,"journal":{"name":"Systematic Reviews","volume":"14 1","pages":"155"},"PeriodicalIF":3.9,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12302900/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144733378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative assessment of Cochrane's ROB and ROB2 in dentistry trials: a meta-research study.","authors":"João Viana, Vanessa Machado, Luís Proença, Leandro Chambrone, José João Mendes, João Botelho","doi":"10.1186/s13643-025-02901-4","DOIUrl":"10.1186/s13643-025-02901-4","url":null,"abstract":"<p><p>This meta-research study aimed to compare the assessment of Cochrane's Risk of Bias (RoB) and RoB2 tools in dentistry trials. A sample 150 in vivo randomized clinical trials published between 2020 and 2022 was randomly selected from PubMed/Medline, Scopus, and EMBASE databases (50 per year). For each study, the impact factor, journal quartile, adherence to CONSORT guidelines, date information availability, and study model were recorded. The results showed that 33.3% of the studies were categorized as low risk of bias by both RoB and RoB2. However, 29.6% of the studies classified as low risk by RoB were downgraded to some concerns in RoB2, and 37% were downgraded to high risk. In the some concerns category, 25.9% were upgraded to low risk, 37% remained constant, and 37% were downgraded to high risk in RoB2. Among the high risk studies, 14.6% were upgraded to low risk, 26% to some concerns, and 59.4% remained constant in RoB2. The level of agreement between RoB and RoB2 was found to be low for dental studies. These findings highlight the differences between the two tools and the potential impact on the synthesis of evidence and decision-making processes in dental research.</p>","PeriodicalId":22162,"journal":{"name":"Systematic Reviews","volume":"14 1","pages":"154"},"PeriodicalIF":3.9,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12302898/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144733377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A systematic review and meta-analysis testing the effect of lifestyle modification and medication optimization programs on cholesterol and blood pressure in patients with cardiovascular disease.","authors":"Semagn Mekonnen Abate, Shivshankar Thanigaimani, Mallika Sinha, David Sun, Jonathan Golledge","doi":"10.1186/s13643-025-02857-5","DOIUrl":"10.1186/s13643-025-02857-5","url":null,"abstract":"<p><strong>Background: </strong>Cardiovascular diseases (CVDs) are the leading cause of mortality and morbidity globally, and a number of treatment and preventive strategies have been tried for years. Lifestyle modification programs have been widely implemented as a primary prevention strategy to reduce the burden of CVDs. However, their effectiveness in patients with established CVD in monitoring modifiable risk factors is controversial and requires further investigation.</p><p><strong>Methods: </strong>A comprehensive search was conducted in PubMed, Cochrane, Science Direct, and LILACS without date and language restrictions. All randomized controlled trials (RCT) comparing the effectiveness of lifestyle modification and/ or optimization of drug therapies among patients with established cardiovascular disease were included. The primary outcomes were changes in systolic blood pressure and low-density lipoprotein cholesterol. Secondary outcomes included changes in total cholesterol, diastolic blood pressure, and medication adherence. Meta-analysis results were reported as standardized mean difference (SMD) or risk ratio (RR) and 95% confidence intervals (CI). Sub-analyses examined programs that included both lifestyle modification and drug optimization or type of intervention alone if a minimum of three trials were identified. The quality of evidence was evaluated using GRADE and trial sequential analyses.</p><p><strong>Results: </strong>Sixteen trials including 4450 participants were included in testing programs focused on both lifestyle modification and drug optimisation (seven RCTs) and lifestyle modification alone (nine RCTs). Overall the programs significantly reduced systolic blood pressure (SMD =  - 0.30, 95% CI - 0.43 to - 0.17, P < 0.001), diastolic blood pressure (SMD =  - 0.18, 95% CI - 0.28 to - 0.08 P < 0.001), total cholesterol (SMD =  - 0.28, 95% CI - 0.49 to - 0.07, P = 0.009); however, the quality of evidence was rated as low.</p><p><strong>Conclusion: </strong>Lifestyle modification and medication optimization interventions had a significant effect on monitoring blood pressure and serum cholesterol; however, the provision of the firm conclusion is less optimal with current evidence as the quality of evidence was low.</p><p><strong>Systematic review registration: </strong>The systematic review and meta-analysis protocol was registered in PROSPERO CRD42024523078.</p>","PeriodicalId":22162,"journal":{"name":"Systematic Reviews","volume":"14 1","pages":"153"},"PeriodicalIF":3.9,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12302857/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144733376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is noxious stimulus-evoked electroencephalography response a reliable, valid, and interpretable outcome measure to assess analgesic efficacy in neonates? A systematic review and individual participant data (IPD) meta-analysis protocol.","authors":"Luke Baxter, Marianne van der Vaart, Maria M Cobo, Patricia Y Gunawan, Karel Allegaert, Jonathan M Davis, Mark Turner, Robert M Ward, Edress Darsey, James P Sheppard, Aomesh Bhatt, John van den Anker, An N Massaro, Ramona L Walls, Laura S Song, Kanwaljit Singh, Rebeccah Slater","doi":"10.1186/s13643-025-02890-4","DOIUrl":"10.1186/s13643-025-02890-4","url":null,"abstract":"<p><strong>Background: </strong>There are several major challenges limiting our ability to test analgesic efficacy for treatment of neonatal pain, and progress in analgesic drug studies in neonates has stalled. One significant issue is the reliance of clinical pain assessments on traditional behavioural and vital signs-based measures and the exclusion of novel brain-based biomarkers. In this review protocol, we outline our strategy to assess the reliability, validity, and interpretability of an electroencephalography (EEG)-based response biomarker for assessment of acute somatic nociceptive pain in neonates.</p><p><strong>Methods: </strong>To standardise EEG analysis and generate the outcome of interest, we will perform an individual participant data (IPD) meta-analysis using data from neonates aged 34-44-week postmenstrual age that have had EEG recorded during acute somatic nociceptive skin-breaking procedures. Relevant data from both published and grey literature will be identified by searching six databases (MEDLINE, Embase, CINAHL, Web of Science, Scopus, Google Scholar), two clinical trial registry platforms (ClinicalTrials.gov, WHO ICTRP), and by consulting expert opinion. We will assess availability bias, data accuracy, and data quality by cross-referencing provided data with data descriptions in the literature, identifying duplicates and nonsensical values, and extracting quality control metrics. Data will be synthesised via a two-stage IPD meta-analysis using a random effects modelling approach grouped by site. Reliability (inter- and intra-rater) outcomes will be measured as Gwet's AC1 coefficient. Validity (known-groups and known-stimuli) outcomes will be measured as EEG response magnitude differences between clinically meaningfully different stimuli. Interpretability will be addressed by providing normative values, in both original and standardised units.</p><p><strong>Discussion: </strong>The purpose of this study is to establish the reliability, validity, and interpretability of a specific EEG-based response biomarker for assessing acute somatic nociceptive pain in neonates. It will provide an overview of available data and how EEG is being used globally to assess acute neonatal pain. If sufficient IPD are made available and the outcome is reliable, valid, and interpretable, this work will support the use of EEG-based outcome measures as primary endpoints in clinical trials assessing analgesic efficacy in neonates.</p><p><strong>Systematic review registration: </strong>The protocol was registered with PROSPERO on 14 July 2023: CRD42023444809.</p>","PeriodicalId":22162,"journal":{"name":"Systematic Reviews","volume":"14 1","pages":"152"},"PeriodicalIF":3.9,"publicationDate":"2025-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12296588/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144718704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between dietary antioxidants and hypertension with the role of genetic factors: a scoping review protocol.","authors":"Tao Liu, Jianwei Zeng, Miao Huang, Ru Fu, Xiaogang Li, Weihong Jiang","doi":"10.1186/s13643-025-02913-0","DOIUrl":"10.1186/s13643-025-02913-0","url":null,"abstract":"<p><strong>Background: </strong>Hypertension is one of the most common cardiovascular diseases and is responsible for numerous premature deaths worldwide. Antihypertensive drugs cannot fully achieve both effective blood pressure reduction and sufficient protection of target organs. Oxidative stress is considered a critical factor in the development of hypertension. Diet plays a crucial role in hypertension management due to its routine and non-pharmacological nature, and dietary natural antioxidants are believed to play a role in reducing oxidative stress. To date, no reviews have synthesized the evidence on the relationship between total dietary antioxidant capacity and hypertension, its associated target organ damage, and mortality risk, particularly in the context of genetic factors influencing this relationship. This scoping review aims to fill this gap.</p><p><strong>Methods: </strong>A systematic search will be conducted across five databases, namely PubMed, Embase, the Cochrane Library, EBSCO, and Web of Science, and gray literature sources for papers published, in line with established scoping review frameworks. The search will cover all relevant studies published up to the date of search initiation. The data will be charted and extracted based on the Preferred Reporting Items for Systematic reviews and Meta-Analyses extension for Scoping Reviews. We will conduct a narrative synthesis in alignment with the stated research questions.</p><p><strong>Discussion: </strong>Developing a tailored approach to incorporate dietary antioxidants in hypertension research is crucial for both the scientific community and individuals at risk.</p><p><strong>Systematic review registration: </strong>The scoping review protocol has been registered on the Open Science Framework https://doi.org/10.17605/OSF.IO/A6D4M .</p>","PeriodicalId":22162,"journal":{"name":"Systematic Reviews","volume":"14 1","pages":"151"},"PeriodicalIF":6.3,"publicationDate":"2025-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12275444/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144668557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychometric properties of the Warwick Edinburgh Mental Well-being Scale: a systematic review.","authors":"B P R Perera, A R Wickremasinghe, T A P De Za","doi":"10.1186/s13643-025-02897-x","DOIUrl":"10.1186/s13643-025-02897-x","url":null,"abstract":"<p><strong>Background: </strong>Patient reported outcomes are increasingly being assessed in many studies due to the demand for reliable and valid measures that enable assessment of such outcomes and comparison of scores between different populations. The Warwick Edinburgh Mental Well-being Scale (WEMWBS) and its shorter version (SWEMWBS) are widely used questionnaires that assess subjective mental well-being at the population level. The scales have been translated into many languages and are being used in a variety of settings to assess well-being. This systematic review aimed to evaluate the psychometric properties of the available versions of the scale.</p><p><strong>Methods: </strong>The protocol was registered in the International Prospective Register of Systematic Reviews (PROSPERO registration number CRD42020149849) reports the psychometric properties reported by validation studies published until 31 December 2023. A search for 'WEMWBS' and/or 'Warwick Edinburgh Mental Well-being Scale', used in combination with 'validation', was used to search PubMed, Semantic Scholar, OpenGrey, and the first 10 pages of Google Scholar. One author screened all titles after duplicates and unrelated items were removed. The abstracts of the remaining studies (n = 142) were screened and suitable articles were selected for data extraction. Methodological quality was independently assessed by two investigators against the CONSensus-based Standards for the Selection of Health Measurement Instruments (COSMIN) risk of bias assessment checklist. The articles were evaluated and compared based on the reported translation process, internal consistency reliability and test-retest reliability, construct validity, responsiveness to change, and discriminatory power.</p><p><strong>Results: </strong>Fifty-six full-text articles were included in the study and were assessed for adherence to the accepted translation protocol and reporting of reliability and validity criteria. Many studies that have translated the instrument have focused on forward and backward translation without paying much attention to the appraisal of the translation. Most reports of internal consistency were within acceptable limits. However, test-retest reliability was not often assessed. The instrument has been administered online and in person. The instrument was well received by many populations; the instrument was able to capture changes in well-being scores between subgroups and post intervention.</p><p><strong>Conclusion: </strong>The WEMWBS can be used to assess mental well-being in populations; it provides reliable assessments and is responsive to change. Cognitive assessments and pretesting of the scale prior to data collection are strongly advised.</p><p><strong>Systematic review registration: </strong>PROSPERO CRD42020149849.</p>","PeriodicalId":22162,"journal":{"name":"Systematic Reviews","volume":"14 1","pages":"149"},"PeriodicalIF":6.3,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12273187/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144668537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of the MicroBiome in PANCreatic cancer and its precursors- the study protocol of the MiBiPanc systematic review and meta-analysis.","authors":"My-Lan Pianka, Alexander Werba, Samuel Zimmermann, Johannes A Vey, Eva Kalkum, Solveig Tenckoff, Andrew Tony-Odigie, Christoph W Michalski, Frank Pianka","doi":"10.1186/s13643-025-02910-3","DOIUrl":"10.1186/s13643-025-02910-3","url":null,"abstract":"<p><strong>Background: </strong>Pancreatic cancer is the third leading cause of cancer-related death in Northern America and fourth in Europe. Emerging evidence suggests that the pancreatic microbiome may play a significant role in the development and progression of this disease. Although the human microbiota contributes to health by supporting nutritional and hormonal homeostasis, modulating inflammation, detoxifying harmful compounds, and producing beneficial metabolites, several studies have implicated its crucial modulatory role in numerous diseases, including cancer. The main objective of this review is to investigate the specific relationship between the microbiome and pancreatic carcinogenesis.</p><p><strong>Methods: </strong>A comprehensive literature search will identify studies examining the microbiome in human samples of saliva, pancreatic fluid, bile, pancreatic tissue, and feces of patients with chronic pancreatitis, precancerous pancreatic lesions, and pancreatic cancer. Studies differentiating bacteria to at least the genus level will be prioritized. Eligible studies include randomized controlled trials and observational studies analyzing the human microbiome in patients with chronic pancreatitis, pancreatic precursor lesions, or pancreatic cancer compared to healthy controls. Studies analyzing nonhuman samples, single bacterial strains, or lacking comparator groups will be excluded. The following databases will be searched without any restrictions to the publication date up until December 2024: the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE (via PubMed), Embase, and Web of Science. Animal studies, case reports, and studies not reporting analyses of human samples are excluded. Details regarding blinding, risk of bias, and funding sources will be extracted and assessed. The main outcomes include the bacterial diversity in each sample type (stool, saliva, bile, intratumoral, and tissue) itemized for each diagnosis, identifying differentially abundant or depleted taxa, and evaluating the correlation of specific bacteria with disease prevention or progression and clinical outcomes. Data extraction will be performed independently by two reviewers. Risk-of-bias assessment will be performed using Cochrane tools appropriate for each study design. Comparisons will be analyzed by descriptive statistics, and meta-analyses will be performed when applicable. The review will be conducted according to the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines.</p><p><strong>Discussion: </strong>In summary, this systematic review aims to synthesize studies analyzing microbiome profiles in patients with chronic pancreatitis, precursor lesions, and pancreatic cancer, focusing on identifying bacterial diversity and specific taxa related to disease progression and development of cancer in comparison to healthy controls and will include a thorough critical appraisal of the available literature. Ant","PeriodicalId":22162,"journal":{"name":"Systematic Reviews","volume":"14 1","pages":"150"},"PeriodicalIF":6.3,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12273363/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144668558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}