Progress in molecular biology and translational science最新文献_第6页

Preface. 前言。

3区生物学

Progress in molecular biology and translational science Pub Date : 2025-01-01 DOI: 10.1016/S1877-1173(25)00119-X

引用次数: 0

Peptidomimetics design and characterization: Bridging experimental and computer-based approaches. 拟态肽设计与表征：连接实验与计算机方法。

3区生物学

Progress in molecular biology and translational science Pub Date : 2025-01-01 Epub Date: 2024-07-25 DOI: 10.1016/bs.pmbts.2024.07.002

Alice Romagnoli, Jesmina Rexha, Nunzio Perta, Samuele Di Cristofano, Noemi Borgognoni, Gloria Venturini, Francesco Pignotti, Domenico Raimondo, Tiziana Borsello, Daniele Di Marino

{"title":"Peptidomimetics design and characterization: Bridging experimental and computer-based approaches.","authors":"Alice Romagnoli, Jesmina Rexha, Nunzio Perta, Samuele Di Cristofano, Noemi Borgognoni, Gloria Venturini, Francesco Pignotti, Domenico Raimondo, Tiziana Borsello, Daniele Di Marino","doi":"10.1016/bs.pmbts.2024.07.002","DOIUrl":"10.1016/bs.pmbts.2024.07.002","url":null,"abstract":"Peptidomimetics, designed to mimic peptide biological activity with more drug-like properties, are increasingly pivotal in medicinal chemistry. They offer enhanced systemic delivery, cell penetration, target specificity, and protection against peptidases when compared to their native peptide counterparts. Already utilized in treating diverse diseases like neurodegenerative disorders, cancer and infectious diseases, their future in medicine seems bright, with many peptidomimetics in clinical trials or development stages. Peptidomimetics are well-suited for addressing disturbed protein-protein interactions (PPIs), which often underlie various pathologies. Structural biology and computational methods like molecular dynamics simulations facilitate rational design, whereas machine learning algorithms accelerate protein structure prediction, enabling efficient drug development. Experimental validation via various spectroscopic, biophysical, and biochemical assays confirms computational predictions and guides further optimization. Peptidomimetics, with their tailored constrained structures, represent a frontier in drug design focused on targeting PPIs. In this overview, we present a comprehensive landscape of peptidomimetics, encompassing perspectives on involvement in pathologies, chemical strategies, and methodologies for their characterization, spanning in silico, in vitro and in cell approaches. With increasing interest from pharmaceutical sectors, peptidomimetics hold promise for revolutionizing therapeutic approaches, marking a new era of precision drug discovery.","PeriodicalId":21157,"journal":{"name":"Progress in molecular biology and translational science","volume":"212 ","pages":"279-327"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143693174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Peptides on patrol: Carrier systems for targeted delivery. 巡逻中的多肽：靶向递送的载体系统。

3区生物学

Progress in molecular biology and translational science Pub Date : 2025-01-01 Epub Date: 2025-01-30 DOI: 10.1016/bs.pmbts.2024.11.001

Vivek P Chavda, Joanna Bojarska

引用次数: 0

Advancements in wearable biosensors: Transforming cardiovascular health monitoring and disease management. 可穿戴生物传感器的进展：改变心血管健康监测和疾病管理。

3区生物学

Progress in molecular biology and translational science Pub Date : 2025-01-01 Epub Date: 2025-05-20 DOI: 10.1016/bs.pmbts.2025.05.006

Perla Boutros, Nour Kassem, Sandra Barteit

引用次数: 0

Advances in materials for wearable biosensors. 可穿戴生物传感器材料的研究进展。

3区生物学

Progress in molecular biology and translational science Pub Date : 2025-01-01 Epub Date: 2025-05-24 DOI: 10.1016/bs.pmbts.2025.05.009

Dhruvesh Maiya, Tvarit Patel, Alok Pandya

{"title":"Advances in materials for wearable biosensors.","authors":"Dhruvesh Maiya, Tvarit Patel, Alok Pandya","doi":"10.1016/bs.pmbts.2025.05.009","DOIUrl":"10.1016/bs.pmbts.2025.05.009","url":null,"abstract":"Wearable biosensors have emerged as transformative instruments for continuous, non-invasive health monitoring, providing real-time analysis of biomarkers in biofluids such as sweat, interstitial fluid, and saliva. This chapter offers a comprehensive overview of the pivotal role of biomaterials in the design and functionality of wearable biosensors. It examines the selection criteria for biocompatible materials, emphasizing properties such as flexibility, stretchability, conductivity, and long-term stability. The discussion categorizes advanced materials, including hydrogels, polyurethanes, carbon-based nanomaterials, metallic nanoparticles, and microneedles, and evaluates their applications in biosensing platforms for glucose, pH, and metal ion detection. Through case studies and figure-integrated explanations, the chapter highlights innovations such as smart hydrogel contact lenses, self-powered alcohol biosensors, and closed-loop microneedle patches for autonomous insulin delivery. It further explores key challenges, including biofluid variability, sensor biocompatibility, and the correlation of biofluid biomarkers with blood concentrations. Finally, the chapter underscores future directions involving AI integration, federated learning, and next-generation biomaterials like biodegradable polymers and stretchable composites. By bridging materials science with digital health technologies, wearable biosensors are poised to revolutionize personalized medicine, enabling early diagnosis, disease prevention, and optimized therapeutic interventions.","PeriodicalId":21157,"journal":{"name":"Progress in molecular biology and translational science","volume":"215 ","pages":"155-179"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144668252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tools and databases for non-coding RNAs. 非编码rna的工具和数据库。

3区生物学

Progress in molecular biology and translational science Pub Date : 2025-01-01 Epub Date: 2025-05-31 DOI: 10.1016/bs.pmbts.2025.05.003

Akshaykumar Zawar, Srinka Datta, Rishita Rathi, Rituja Shinde, Anushka Kalamkar, Neeraj Dangi, Poonam Deshpande

{"title":"Tools and databases for non-coding RNAs.","authors":"Akshaykumar Zawar, Srinka Datta, Rishita Rathi, Rituja Shinde, Anushka Kalamkar, Neeraj Dangi, Poonam Deshpande","doi":"10.1016/bs.pmbts.2025.05.003","DOIUrl":"10.1016/bs.pmbts.2025.05.003","url":null,"abstract":"Non-coding RNAs (ncRNAs) play a crucial role in various cellular processes, challenging the earlier notion that non-coding regions of the genome are merely \"junk DNA.\" Advances in molecular biology and sequencing technologies have revealed that these regions contain essential genetic elements, including ncRNAs, which influence gene regulation and other biological functions. As the significance of ncRNAs in human health and disease becomes increasingly clear, researchers have developed methods to identify, annotate, and classify these molecules into distinct types. Additionally, a growing interest has emerged in studying genetic variations within ncRNA genes and their potential implications in disease development. Understanding these variations can provide insights into how ncRNAs contribute to gene regulation and cellular function. This article explores the current landscape of ncRNA research, highlighting the latest techniques for detecting and identifying different classes of ncRNAs. Furthermore, it discusses computational tools and databases available for annotating ncRNAs and analyzing their functions across various biological processes. By integrating experimental and computational approaches, researchers can gain a deeper understanding of ncRNA roles, paving the way for potential therapeutic applications.","PeriodicalId":21157,"journal":{"name":"Progress in molecular biology and translational science","volume":"214 ","pages":"163-178"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144340310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Wearable privacy. 可穿戴的隐私。

3区生物学

Progress in molecular biology and translational science Pub Date : 2025-01-01 Epub Date: 2025-07-17 DOI: 10.1016/bs.pmbts.2025.06.005

Vivian Genaro Motti, Huining 'Selina' Feng

{"title":"Wearable privacy.","authors":"Vivian Genaro Motti, Huining 'Selina' Feng","doi":"10.1016/bs.pmbts.2025.06.005","DOIUrl":"10.1016/bs.pmbts.2025.06.005","url":null,"abstract":"Wearable technology has a promising potential to transform users' lives by continuously collecting data and providing convenient services on demand. Yet, there is also a large potential to breach users' privacy compromising the confidentiality of sensitive data. The lack of privacy regulations is caused by a limited understanding of how to control data collection, access and sharing. Also, the lack of privacy regulations for wearables hinders effective controls for data sharing. This issue is further complicated due to the lack of policies governing the use of wearables in public places, the novelty of such devices and their services, as well as the challenges to identify the threats to data misuse. In this chapter, we examine the landscape of wearable technology focusing on user privacy and data protection. We describe the implications of data disclosure, discussing risks and benefits involved. We provide scenarios where these issues arise and discuss technical solutions including data anonymization and access controls. We review solutions designed to protect users' privacy rights, evaluating their effectiveness and limitations. Lastly, we present solutions created to protect users' privacy. The chapter concludes by outlining a roadmap for future research and development in wearable privacy. We highlight open questions for next-generation devices and provide practical recommendations for end users to safeguard their privacy. Key areas for future research include enhancing user consent mechanisms and improving transparency in data practices. By addressing these gaps, we aim to better protect user privacy in an increasingly interconnected world.","PeriodicalId":21157,"journal":{"name":"Progress in molecular biology and translational science","volume":"216 ","pages":"27-48"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145024171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Wearable biosensors for cancer detection and monitoring. 用于癌症检测和监测的可穿戴生物传感器。

3区生物学

Progress in molecular biology and translational science Pub Date : 2025-01-01 Epub Date: 2025-05-24 DOI: 10.1016/bs.pmbts.2025.05.005

Navid Kashaninejad, Prabuddha De Saram, Mohamed A Abdelfattah, Azeez Bakare, Hoang Huy Vu

{"title":"Wearable biosensors for cancer detection and monitoring.","authors":"Navid Kashaninejad, Prabuddha De Saram, Mohamed A Abdelfattah, Azeez Bakare, Hoang Huy Vu","doi":"10.1016/bs.pmbts.2025.05.005","DOIUrl":"10.1016/bs.pmbts.2025.05.005","url":null,"abstract":"Wearable biosensors have emerged as game changers in healthcare, particularly for cancer detection and monitoring. Continuously sensing physiological and biochemical markers improves cancer diagnosis and treatment significantly. Conventional diagnostic methods, such as biopsies and imaging, are invasive, expensive, and logistically challenging, limiting their frequency and accessibility. Over the past decade, advances in microfluidics and surface engineering have expanded the capabilities of wearable biosensors. Readily accessible body fluids, such as sweat, saliva, tears, and interstitial fluid (ISF), are now recognized as valuable, non-invasive sources of tumor biomarkers. These fluids provide critical insights into tumor progression and therapy response, offering a patient-friendly alternative to traditional diagnostics. The integration of cutting-edge materials, advanced sensing technologies, and microfluidics has dramatically enhanced the sensitivity and specificity of wearable biosensors. This progress paves the way for personalized and preventive healthcare, improving patient convenience and reducing clinical visits and invasive procedures. This chapter explores the fundamental design principles, practical applications, and existing challenges of wearable biosensors. By addressing these issues, wearable biosensors can play a transformative role in early cancer detection and personalized treatment, ultimately improving patient outcomes.","PeriodicalId":21157,"journal":{"name":"Progress in molecular biology and translational science","volume":"215 ","pages":"311-354"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144668260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Daptomycin: Mechanism of action, mechanisms of resistance, synthesis and structure-activity relationships. 达托霉素：作用机制、耐药机制、合成及构效关系。

3区生物学

Progress in molecular biology and translational science Pub Date : 2025-01-01 Epub Date: 2024-04-27 DOI: 10.1016/bs.pmbts.2024.04.003

Scott D Taylor, Ryan Moreira

{"title":"Daptomycin: Mechanism of action, mechanisms of resistance, synthesis and structure-activity relationships.","authors":"Scott D Taylor, Ryan Moreira","doi":"10.1016/bs.pmbts.2024.04.003","DOIUrl":"10.1016/bs.pmbts.2024.04.003","url":null,"abstract":"Daptomycin is a cyclic lipodepsipeptide antibiotic that is a mainstay for the treatment of serious infections caused by Gram-positive bacteria, including methicillin-resistant Streptococcus aureus and vancomycin resistant enterococci. It is one of the so-called last-resort antibiotics that are used to tackle life-threatening infections that do not respond to first-line treatments. However, resistance to daptomycin is eroding its clinical efficacy motivating the design and/or discovery of analogues that overcome resistance. The strategy of antibiotic analogue synthesis has been used to overcome bacterial resistance to many classes of antibiotics such as the β-lactams. Pursuing this strategy with daptomycin requires a detailed understanding of daptomycin's action mechanism and synthesis. Here, we discuss the action mechanism of daptomycin in a holistic manner and expand this discussion to rationalize conferred modes of resistance. Synthetic efforts, both chemical and biological, are discussed in detail and the structure-activity relationship emanating from these works is distilled into a usable model that can guide the design of new daptomycin analogues.","PeriodicalId":21157,"journal":{"name":"Progress in molecular biology and translational science","volume":"212 ","pages":"163-234"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143693143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The ethical and regulatory landscape of wearable, ingestible, and implantable technologies in the United States. 美国可穿戴、可食用和可植入技术的伦理和监管格局。

3区生物学

Progress in molecular biology and translational science Pub Date : 2025-01-01 Epub Date: 2025-07-19 DOI: 10.1016/bs.pmbts.2025.06.004

Ishaan Jain, George S Sellers, Armaan Jain, Astha Agarwal, Raju S Davé

{"title":"The ethical and regulatory landscape of wearable, ingestible, and implantable technologies in the United States.","authors":"Ishaan Jain, George S Sellers, Armaan Jain, Astha Agarwal, Raju S Davé","doi":"10.1016/bs.pmbts.2025.06.004","DOIUrl":"10.1016/bs.pmbts.2025.06.004","url":null,"abstract":"Biosensing technologies, including wearables, ingestibles, and implantables, are transforming modern healthcare by enabling real-time monitoring and precise personalized treatment. As these technologies advance, ensuring their safety, efficacy, and ethical deployment remains paramount. This chapter explores the regulatory framework that governs biosensing devices in the United States, detailing premarket approval pathways, postmarket surveillance, and emerging regulatory incentives that balance innovation with patient protection. The discussion extends beyond compliance to address critical ethical considerations, including data privacy, informed consent, patient data ownership, and equitable access. By examining case studies of successful and failed biosensing devices, this chapter provides a comprehensive analysis of the evolving landscape, offering guidance for manufacturers, policymakers, and healthcare providers. A proactive approach to regulation and ethics will be essential to ensuring biosensing technologies enhance healthcare outcomes while maintaining public trust.","PeriodicalId":21157,"journal":{"name":"Progress in molecular biology and translational science","volume":"216 ","pages":"49-85"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145024199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0