Progress in molecular biology and translational science最新文献_第6页

Half Title Page 半扉页

3区生物学

Progress in molecular biology and translational science Pub Date : 2024-01-16 DOI: 10.1016/s1877-1173(24)00008-5

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Contributors 贡献者

3区生物学

Progress in molecular biology and translational science Pub Date : 2024-01-16 DOI: 10.1016/s1877-1173(24)00011-5

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Title Page 标题页

3区生物学

Progress in molecular biology and translational science Pub Date : 2024-01-16 DOI: 10.1016/s1877-1173(24)00009-7

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SARS-CoV-2 variant biology and immune evasion SARS-CoV-2 变异生物学和免疫逃避

3区生物学

Progress in molecular biology and translational science Pub Date : 2024-01-04 DOI: 10.1016/bs.pmbts.2023.11.007

Asiya Kamber Zaidi, Rohan Bir Singh

{"title":"SARS-CoV-2 variant biology and immune evasion","authors":"Asiya Kamber Zaidi, Rohan Bir Singh","doi":"10.1016/bs.pmbts.2023.11.007","DOIUrl":"https://doi.org/10.1016/bs.pmbts.2023.11.007","url":null,"abstract":"This chapter discusses the SARS-CoV-2 variants and their immune evasion strategies, shedding light on the dynamic nature of the COVID-19 pandemic. The ecological dynamics and viral evolution of SARS-CoV-2 are explored, considering carriers of infection, individual immunity profiles, and human movement as key factors in the emergence and dissemination of variants. The chapter discusses SARS-CoV-2 mutation, including mutation rate, substitution rate, and recombination, influencing genetic diversity and evolution.Transmission bottlenecks are highlighted as determinants of dominant variants during viral spread. The evolution phases of the pandemic are outlined, from limited early evolution to the emergence of notable changes like the D614G substitution and variants with heavy mutations. Variants of Concern (VOCs), including Alpha, Beta, Gamma, and the recent Omicron variant, are examined, with insights into inter-lineage and intra-lineage dynamics. The origin of VOCs and the Omicron variant is explored, alongside the role of the furin cleavage site (FCS) in variant emergence. The impact of structural and non-structural proteins on viral infectivity is assessed, as well as innate immunity evasion strategies employed by SARS-CoV-2 variants. The chapter concludes by considering future possibilities, including ongoing virus evolution, the need for surveillance, vaccine development, and public health measures.","PeriodicalId":21157,"journal":{"name":"Progress in molecular biology and translational science","volume":"95 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139474774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Epidemiology of COVID-19 COVID-19 的流行病学

3区生物学

Progress in molecular biology and translational science Pub Date : 2024-01-04 DOI: 10.1016/bs.pmbts.2023.09.002

Asiya Kamber Zaidi, Rohan Bir Singh

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Structural biology of SARS-CoV-2 SARS-CoV-2 的结构生物学

3区生物学

Progress in molecular biology and translational science Pub Date : 2024-01-03 DOI: 10.1016/bs.pmbts.2023.11.001

Asiya Kamber Zaidi, Sunny Dawoodi

{"title":"Structural biology of SARS-CoV-2","authors":"Asiya Kamber Zaidi, Sunny Dawoodi","doi":"10.1016/bs.pmbts.2023.11.001","DOIUrl":"https://doi.org/10.1016/bs.pmbts.2023.11.001","url":null,"abstract":"This chapter provides a comprehensive overview of the techniques employed to unravel the structural biology of SARS-CoV-2, facilitating a deeper understanding of the virus for developing future therapeutic strategies. Various techniques such as Electron microscopy (EM) for capturing high-resolution images of the virus and X-ray crystallography used for determining atomic-level structures of viral proteins are discussed. Cryo-electron microscopy (cryo-EM) imaging is also examined as a powerful tool for visualizing the virus's structure in its native state. Intracellular detection and tracking of SARS-CoV-2 are discussed, highlighting the techniques employed to study the virus's behavior within host cells. The chapter further explores how cryo-EM has been instrumental in delivering high-quality structural information on SARS-CoV-2, enabling researchers to better understand its mechanisms of infection and replication. The structural visualization of SARS-CoV-2 is then presented, focusing on key components such as the spike protein structure, RNA polymerase structure, and the visualization of intact and in-situ virions using cryo-electron tomography (cryo-ET). Lastly, the chapter touches upon the application of nuclear magnetic resonance (NMR) spectroscopy for studying the dynamics and interactions of viral proteins","PeriodicalId":21157,"journal":{"name":"Progress in molecular biology and translational science","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139475231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Long Covid Long Covid

3区生物学

Progress in molecular biology and translational science Pub Date : 2024-01-03 DOI: 10.1016/bs.pmbts.2023.11.002

Asiya Kamber Zaidi, Puya Dehgani-Mobaraki

{"title":"Long Covid","authors":"Asiya Kamber Zaidi, Puya Dehgani-Mobaraki","doi":"10.1016/bs.pmbts.2023.11.002","DOIUrl":"https://doi.org/10.1016/bs.pmbts.2023.11.002","url":null,"abstract":"Long COVID, also known as post-acute sequelae of SARS-CoV-2 infection (PASC), refers to a constellation of persistent symptoms and health issues that continue beyond the acute phase of COVID-19. This chapter provides an overview of the pathogenesis, risk factors, manifestations, major findings, and diagnosis and treatment strategies associated with Long COVID. Hypotheses regarding the pathogenesis of Long COVID are discussed, encompassing various factors such as persistent viral reservoirs, immune dysregulation with or without reactivation of herpesviruses (e.g., Epstein-Barr Virus and human herpesvirus), dysbiosis, autoimmunity triggered by infection, endothelial dysfunction, microvessel blood clotting, and dysfunctional brainstem and/or vagal signaling. The chapter also highlights the risk factors associated with Long COVID and its occurrence in children. The major findings of Long COVID, including immune dysregulation, vessel and tissue damage, neurological and cognitive pathology, eye symptoms, endocrinal issues, myalgic encephalomyelitis and chronic fatigue syndrome, reproductive system involvement, respiratory and gastrointestinal symptoms, and the chronology of symptoms, are thoroughly explored. Lastly, the chapter discusses the challenges and current approaches in the diagnosis and treatment of Long COVID, emphasizing the need for multidisciplinary care and individualized management strategies.","PeriodicalId":21157,"journal":{"name":"Progress in molecular biology and translational science","volume":"24 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139474653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Advances in CRISPR-Cas systems for gut microbiome. 用于肠道微生物组的 CRISPR-Cas 系统的进展。

3区生物学

Progress in molecular biology and translational science Pub Date : 2024-01-01 Epub Date: 2024-08-22 DOI: 10.1016/bs.pmbts.2024.07.008

Namra Ali, Chaitali Vora, Anshu Mathuria, Naina Kataria, Indra Mani

{"title":"Advances in CRISPR-Cas systems for gut microbiome.","authors":"Namra Ali, Chaitali Vora, Anshu Mathuria, Naina Kataria, Indra Mani","doi":"10.1016/bs.pmbts.2024.07.008","DOIUrl":"https://doi.org/10.1016/bs.pmbts.2024.07.008","url":null,"abstract":"CRISPR-Cas technology has revolutionized microbiome research by enabling precise genetic manipulation of microbial communities. This review explores its diverse applications in gut microbiome studies, probiotic development, microbiome diagnostics, pathogen targeting, and microbial community engineering. Engineered bacteriophages and conjugative probiotics exemplify CRISPR-Cas's capability for targeted bacterial manipulation, offering promising strategies against antibiotic-resistant infections and other gut-related disorders. CRISPR-Cas systems also enhance probiotic efficacy by improving stress tolerance and colonization in the gastrointestinal tract. CRISPR-based techniques in diagnostics enable early intervention by enabling fast and sensitive pathogen identification. Furthermore, CRISPR-mediated gene editing allows tailored modification of microbial populations, mitigating risks associated with horizontal gene transfer and enhancing environmental and health outcomes. Despite its transformative potential, ethical and regulatory challenges loom large, demanding robust frameworks to guide its responsible application. This chapter highlights CRISPR-Cas's pivotal role in advancing microbiome research toward personalized medicine and microbial therapeutics while emphasizing the imperative of balanced ethical deliberations and comprehensive regulatory oversight.","PeriodicalId":21157,"journal":{"name":"Progress in molecular biology and translational science","volume":"208 ","pages":"59-81"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142294135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Rational design of adjuvants boosts cancer vaccines. 合理设计佐剂可提高癌症疫苗的疗效。

3区生物学

Progress in molecular biology and translational science Pub Date : 2024-01-01 Epub Date: 2024-03-22 DOI: 10.1016/bs.pmbts.2024.03.001

Xia Li, Tomohiko Yamazaki, Mitsuhiro Ebara, Naoto Shirahata, Nobutaka Hanagata

{"title":"Rational design of adjuvants boosts cancer vaccines.","authors":"Xia Li, Tomohiko Yamazaki, Mitsuhiro Ebara, Naoto Shirahata, Nobutaka Hanagata","doi":"10.1016/bs.pmbts.2024.03.001","DOIUrl":"https://doi.org/10.1016/bs.pmbts.2024.03.001","url":null,"abstract":"Cancer vaccines are expected to be next breakthrough in cancer immunotherapy. In cancer vaccines, adjuvants play an important role by enhancing and reshaping tumor antigen-specific immune responses. Failures in previous cancer vaccine clinical trials can be attributed to inappropriate selection and design of tumor antigens and adjuvants. Using basic theories of tumor immunology, the development of sequencing technology and nanotechnology enables the creation of cancer vaccines through appropriate selection of tumor antigens and adjuvants and their nanoscale assembly based on the specific characteristics of each tumor. In this chapter, we begin by discussing the various types of cancer vaccines and categories of tumor antigens. Then, we summarize the classification of adjuvants for cancer vaccines, including immunostimulatory molecules and delivery systems, and clarify the various factors that influence the properties of adjuvants, such as chemical composition, structure, and surface modification. Finally, we provide perspectives and insights on rational design of adjuvants in cancer vaccines to enhance their efficacy.","PeriodicalId":21157,"journal":{"name":"Progress in molecular biology and translational science","volume":"209 ","pages":"101-125"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142506949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Non-coding RNAs in cancer immunotherapy: A solution to overcome immune resistance? 癌症免疫疗法中的非编码 RNA：克服免疫耐受的解决方案？

3区生物学

Progress in molecular biology and translational science Pub Date : 2024-01-01 Epub Date: 2024-03-31 DOI: 10.1016/bs.pmbts.2024.02.003

Fatemeh Afra, Seyed Parsa Eftekhar, Amir Salehi Farid, Moein Ala

{"title":"Non-coding RNAs in cancer immunotherapy: A solution to overcome immune resistance?","authors":"Fatemeh Afra, Seyed Parsa Eftekhar, Amir Salehi Farid, Moein Ala","doi":"10.1016/bs.pmbts.2024.02.003","DOIUrl":"https://doi.org/10.1016/bs.pmbts.2024.02.003","url":null,"abstract":"With the rapid advancement in immunotherapy, cancer immune resistance has become more evident, which demands new treatment approaches to achieve greater efficacy. Non-coding RNAs (ncRNAs) are a heterogeneous group of RNAs that are not translated to proteins but instead regulate different stages of gene expression. Recent studies have increasingly supported the critical role of ncRNAs in immune cell-cancer cell cross-talk, and numerous ncRNAs have been implicated in the immune evasion of cancer cells. Cancer cells take advantage of ncRNAs to modulate several signaling pathways and upregulate the expression of immune checkpoints and anti-inflammatory mediators, thereby dampening the anti-tumor response of M1 macrophages, dendritic cells, cytotoxic T cells, and natural killer cells or potentiating the immunosuppressive properties of M2 macrophages, regulatory T cells, and myeloid-derived suppressive cells. Upregulation of immunosuppressive ncRNAs or downregulation of immunogenic ncNRAs is a major driver of resistance to immune checkpoint inhibitors, cancer vaccines, and other means of cancer immunotherapy, making ncRNAs ideal targets for treatment. In addition, ncRNAs released by cancer cells have been demonstrated to possess prognostic values for patients who undergo cancer immunotherapy. Future clinical trials are urged to consider the potential of ncRNAs in cancer immunotherapy.","PeriodicalId":21157,"journal":{"name":"Progress in molecular biology and translational science","volume":"209 ","pages":"215-240"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142506947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0