Progress in molecular biology and translational science最新文献_第5页

Dissecting ncRNA pathways and omics integration. 剖析ncRNA通路和组学整合。

3区生物学

Progress in molecular biology and translational science Pub Date : 2025-01-01 Epub Date: 2025-03-19 DOI: 10.1016/bs.pmbts.2025.01.001

Peter Chinedu Agu

{"title":"Dissecting ncRNA pathways and omics integration.","authors":"Peter Chinedu Agu","doi":"10.1016/bs.pmbts.2025.01.001","DOIUrl":"10.1016/bs.pmbts.2025.01.001","url":null,"abstract":"This chapter x-rays the pivotal roles of non-coding RNAs (ncRNAs) in gene regulation and cellular processes with emphasis on their diverse functions and mechanisms. The ncRNA types, which include miRNAs, siRNAs, and lncRNAs were highlighted stating their significance in gene regulation and disease. Then, the biogenesis and functional roles of these ncRNAs were explained with a focus on their transcription, processing, and mechanisms of action such as RNA interference and gene silencing. Furthermore, the chapter delves into the pathways of miRNAs, siRNAs, and lncRNAs to elucidate their regulatory roles in chromatin remodeling, transcription, and post-transcriptional processes. Omics technologies, including genomics, transcriptomics, proteomics, and epigenomics were piqued for their transformative impact on ncRNA research towards enabling comprehensive analysis and discovery of novel ncRNA functions. Consistently, the integration of multi-omics data, showcasing bioinformatics tools, and exemplified studies that reveal ncRNA networks and systems biology approaches were highlighted. These led to the suggestion that addressing technical and computational challenges, such as data quality, reproducibility, and integration is pivotal to future advancements in applications of lncRNA. Therefore, dissecting ncRNA Pathways and Omics Integration shows the potential applications of ncRNA research in personalized medicine and therapeutics which has culminated in its growing significance in biomedical research and its promise for innovative treatment strategies.","PeriodicalId":21157,"journal":{"name":"Progress in molecular biology and translational science","volume":"214 ","pages":"81-100"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144340380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Structural prediction of potent non-coding RNAs. 强效非编码rna的结构预测。

3区生物学

Progress in molecular biology and translational science Pub Date : 2025-01-01 Epub Date: 2025-05-27 DOI: 10.1016/bs.pmbts.2025.05.002

Abhijit Beura, Gowrang Kasaba Manjunath, Tikam Chand Dakal, Abhishek Kumar

{"title":"Structural prediction of potent non-coding RNAs.","authors":"Abhijit Beura, Gowrang Kasaba Manjunath, Tikam Chand Dakal, Abhishek Kumar","doi":"10.1016/bs.pmbts.2025.05.002","DOIUrl":"10.1016/bs.pmbts.2025.05.002","url":null,"abstract":"Non-coding RNAs (ncRNAs) are vital regulatory molecules that play critical roles in gene expression, cellular signaling, and various biological processes. This review explores the diverse types of ncRNAs, including microRNAs, small interfering RNAs, and long non-coding RNAs, emphasizing their structural features and functional implications. Accurate structural predictions of ncRNAs are essential for understanding their interactions with other biomolecules and developing therapeutic strategies. Advances in computational methods and experimental techniques are enhancing our ability to predict RNA structures and elucidate their roles in health and disease. Despite significant progress, challenges remain in accurately modeling complex RNA structures and understanding the dynamic nature of RNA folding. Future research directions will focus on integrating multi-omics data, refining prediction algorithms, and addressing ethical considerations associated with ncRNA-based therapies. The potential applications of ncRNAs in drug discovery, biomarker identification, and synthetic biology underscore their importance in modern biomedical research.","PeriodicalId":21157,"journal":{"name":"Progress in molecular biology and translational science","volume":"214 ","pages":"101-143"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144340309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Vaccines reimagined: The peptide revolution in disease prevention. 重新构想疫苗：疾病预防中的肽革命。

3区生物学

Progress in molecular biology and translational science Pub Date : 2025-01-01 Epub Date: 2025-01-30 DOI: 10.1016/bs.pmbts.2024.11.002

Vivek P Chavda

引用次数: 0

Implantable biosensors: Advancements and applications. 植入式生物传感器：进展与应用。

3区生物学

Progress in molecular biology and translational science Pub Date : 2025-01-01 Epub Date: 2025-07-05 DOI: 10.1016/bs.pmbts.2025.06.006

Gurleen K Nirwal, Kevin Y Wu, Taanvee P Ramnawaz, Yue Xu, Marjorie Carbonneau, Bich H Nguyen, Simon D Tran

{"title":"Implantable biosensors: Advancements and applications.","authors":"Gurleen K Nirwal, Kevin Y Wu, Taanvee P Ramnawaz, Yue Xu, Marjorie Carbonneau, Bich H Nguyen, Simon D Tran","doi":"10.1016/bs.pmbts.2025.06.006","DOIUrl":"10.1016/bs.pmbts.2025.06.006","url":null,"abstract":"This chapter, \"Implantable Biosensors: Advancements and Applications,\" provides a succinct overview of the state-of-the-art in implantable biosensor technology, highlighting both established clinical uses and promising areas of ongoing research. It begins by outlining the fundamental principles and advantages of these sensors, such as their precision in physiological monitoring and capability for real-time therapeutic interventions. A variety of implantable sensors are categorized, including biophysical and biochemical types, each designed for specific medical applications. In endocrinology, continuous glucose monitoring (CGM) systems represent a pivotal and well-established use of implantable biosensors for diabetes management. In contrast, applications in ophthalmology, such as sensors for monitoring intraocular pressure to prevent glaucoma, are still under investigation and not yet widely adopted in clinical practice, though they hold significant promise. The chapter also explores potential applications across other medical fields, including cardiology, neurology, gastroenterology, pulmonology, otolaryngology, urology, orthopedics, pharmacology, and oncology. These areas are witnessing innovative research and development efforts aimed at harnessing the potential of implantable biosensors for enhanced patient care. The integration of these sensors with drug delivery systems and their role in real-time disease biomarker monitoring underscore their transformative potential. In summary, this chapter highlights the significant advancements in implantable biosensors, emphasizing their current clinical applications and future possibilities in revolutionizing medical diagnostics and treatment.","PeriodicalId":21157,"journal":{"name":"Progress in molecular biology and translational science","volume":"216 ","pages":"279-312"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145024127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preface. 前言。

3区生物学

Progress in molecular biology and translational science Pub Date : 2025-01-01 DOI: 10.1016/S1877-1173(25)00044-4

引用次数: 0

Ingestible biosensors for monitoring digestive health and nutritional monitoring. 用于监测消化健康和营养监测的可消化生物传感器。

3区生物学

Progress in molecular biology and translational science Pub Date : 2025-01-01 Epub Date: 2025-07-16 DOI: 10.1016/bs.pmbts.2025.06.007

Malvika Shukla, Alok Pandya

引用次数: 0

Delivery of protein therapeutics and vaccines using their multivalent complexes with synthetic polyelectrolytes. 利用蛋白质治疗剂和疫苗的多价复合物与合成聚电解质的递送。

3区生物学

Progress in molecular biology and translational science Pub Date : 2025-01-01 Epub Date: 2024-05-03 DOI: 10.1016/bs.pmbts.2024.04.005

Alexander K Andrianov

{"title":"Delivery of protein therapeutics and vaccines using their multivalent complexes with synthetic polyelectrolytes.","authors":"Alexander K Andrianov","doi":"10.1016/bs.pmbts.2024.04.005","DOIUrl":"10.1016/bs.pmbts.2024.04.005","url":null,"abstract":"Clinical applications of protein and peptide-based therapeutics and vaccines are rapidly expanding. However, the development of promising new product candidates is often hindered by unfavorable pharmacokinetic profiles, which necessitate the implementation of drug delivery systems to improve protein stability and bioavailability. Non-covalent modification of proteins with synthetic polyelectrolytes, which relies on the strength of cooperative multivalent interactions, may offer potential advantages. In contrast to commonly employed covalent conjugation or microencapsulation methodologies, this technology offers dynamic protection of the protein thereby minimizing the loss of its biological activity, enabling \"mix-and-match\" formulation approaches, reducing manufacturing costs and simplifying regulatory processes. The range of potential life sciences applications ranges from immunopotentiation and vaccine delivery systems to long-circulating stealth biotherapeutics. This review analyses current technology in the context of intended clinical indications and discusses various synthetic and formulation approaches leading to supramolecular complexation. It evaluates dynamic interactions of complexes with constituents of physiological compartments and attempts to identify critical factors that can affect future advancement of this paradigm-shifting protein delivery technology.","PeriodicalId":21157,"journal":{"name":"Progress in molecular biology and translational science","volume":"212 ","pages":"235-259"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143693145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Membrane-active peptides for anticancer therapies. 用于抗癌治疗的膜活性肽。

3区生物学

Progress in molecular biology and translational science Pub Date : 2025-01-01 Epub Date: 2024-11-01 DOI: 10.1016/bs.pmbts.2024.10.005

Charles H Chen

{"title":"Membrane-active peptides for anticancer therapies.","authors":"Charles H Chen","doi":"10.1016/bs.pmbts.2024.10.005","DOIUrl":"10.1016/bs.pmbts.2024.10.005","url":null,"abstract":"Membrane-active peptides are found in many living organisms and play a critical role in their immune systems by combating various infectious diseases. These host defense peptides employ multiple mechanisms against different microorganisms and possess unique functions, such as anti-inflammatory and immunomodulatory effects, often working in synergy with other antimicrobial agents. Despite extensive research over the past few decades and the identification of thousands of sequences, only a few have been successfully applied in clinical settings and received approval from the U.S. Food and Drug Administration. In this chapter, we explore all peptide therapeutics that have reached the market, as well as candidates in preclinical and clinical trials, to understand their success and potential applications in cancer therapy. Our findings indicate that at least four membrane-active peptide drugs have progressed to preclinical or clinical phases, dmonstrating promising results for cancer treatment. We summarize our insights in this chapter, highlighting the potential of membrane-active anticancer peptide therapeutics and their applications as targeting ligands in various biomedical fields.","PeriodicalId":21157,"journal":{"name":"Progress in molecular biology and translational science","volume":"212 ","pages":"67-116"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143693149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biofluid-based biosensors: Analyzing biomarkers for disease detection. 基于生物流体的生物传感器：分析疾病检测的生物标志物。

3区生物学

Progress in molecular biology and translational science Pub Date : 2025-01-01 Epub Date: 2025-05-03 DOI: 10.1016/bs.pmbts.2025.04.001

Hossein Chenani, Mohsen Saeidi, Abdolreza Simchi

{"title":"Biofluid-based biosensors: Analyzing biomarkers for disease detection.","authors":"Hossein Chenani, Mohsen Saeidi, Abdolreza Simchi","doi":"10.1016/bs.pmbts.2025.04.001","DOIUrl":"10.1016/bs.pmbts.2025.04.001","url":null,"abstract":"The advancement of biofluid-based biosensors (BBs) generates significant interest owing to their capacity for non-invasive, real-time health assessment. These biosensors, proficient in assessing biomarkers in body fluids like sweat, saliva, interstitial fluid, tears, blood, and urine, provide significant benefits in illness detection and individualized healthcare. Recent breakthroughs in sensor technology, encompassing the incorporation of nanomaterials, microfluidics, and wearable electronics, have markedly enhanced the sensitivity, specificity, and portability of biosensors. This chapter examines different types of biosensors, elucidating their functions and applications in the monitoring of various diseases, including metabolic disorders, infectious diseases, and cancer. It also tackles critical issues in the development and implementation of BBs, including attaining long-term stability, standardizing sampling techniques, and confirming their clinical diagnostic efficacy. Current trends are examined, especially the use of artificial intelligence and data analytics for biosensor data interpretation. Finally, the chapter provides some thoughts on the possible integration of these technologies into telemedicine and wearable health devices and their prospects for the future of digital healthcare.","PeriodicalId":21157,"journal":{"name":"Progress in molecular biology and translational science","volume":"215 ","pages":"63-99"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144668253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advanced energy storage systems as power sources for biosensing technologies. 作为生物传感技术动力源的先进储能系统。

3区生物学

Progress in molecular biology and translational science Pub Date : 2025-01-01 Epub Date: 2025-05-31 DOI: 10.1016/bs.pmbts.2025.05.012

Clara R Pereira, André M Pereira, Joana S Teixeira, Ana R Sousa, Gabriela P Queirós, Rui S Costa, Marta S Nunes, Mariana Rocha

引用次数: 0