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3区 生物学
Progress in molecular biology and translational science Pub Date : 2023-04-03 DOI: 10.1016/s1877-1173(23)00104-7
{"title":"Index","authors":"","doi":"10.1016/s1877-1173(23)00104-7","DOIUrl":"https://doi.org/10.1016/s1877-1173(23)00104-7","url":null,"abstract":"Abstract not available","PeriodicalId":21157,"journal":{"name":"Progress in molecular biology and translational science","volume":"27 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138530891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Copyright 版权
3区 生物学
Progress in molecular biology and translational science Pub Date : 2023-04-03 DOI: 10.1016/s1877-1173(23)00100-x
{"title":"Copyright","authors":"","doi":"10.1016/s1877-1173(23)00100-x","DOIUrl":"https://doi.org/10.1016/s1877-1173(23)00100-x","url":null,"abstract":"Abstract not available","PeriodicalId":21157,"journal":{"name":"Progress in molecular biology and translational science","volume":"184 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138530898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Insight into epigenetics and human diseases. 洞察表观遗传学和人类疾病。
3区 生物学
Progress in molecular biology and translational science Pub Date : 2023-01-01 DOI: 10.1016/bs.pmbts.2023.01.007
Ankita Saini, Adya Varshney, Ashok Saini, Indra Mani
{"title":"Insight into epigenetics and human diseases.","authors":"Ankita Saini,&nbsp;Adya Varshney,&nbsp;Ashok Saini,&nbsp;Indra Mani","doi":"10.1016/bs.pmbts.2023.01.007","DOIUrl":"https://doi.org/10.1016/bs.pmbts.2023.01.007","url":null,"abstract":"<p><p>The most eminent research of the 21st century whirls around the epigenetic and the variability of DNA sequences in humans. The reciprocity between the epigenetic changes and the exogenous factors drives an influence on the inheritance biology and gene expression both inter-generationally and trans-generationally. Chromatin level modifications like DNA methylation, histone modifications or changes in transcripts functions either at transcription level or translational level pave the way for certain diseases or cancer in humans. The ability of epigenetics to explain the processes of various diseases has been demonstrated by recent epigenetic studies. Multidisciplinary therapeutic strategies were developed in order to analyse how epigenetic elements interact with different disease pathways. In this chapter we summarize how an organism may be predisposed to certain diseases by exposure to environmental variables such as chemicals, medications, stress, or infections during particular, vulnerable phases of life, and the epigenetic component may influence some of the diseases in humans.</p>","PeriodicalId":21157,"journal":{"name":"Progress in molecular biology and translational science","volume":"197 ","pages":"1-21"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9264657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mechanisms of DNA methylation and histone modifications. DNA甲基化和组蛋白修饰的机制。
3区 生物学
Progress in molecular biology and translational science Pub Date : 2023-01-01 DOI: 10.1016/bs.pmbts.2023.01.001
Santoshi Acharjee, Shraddha Chauhan, Rajshree Pal, Raghuvir Singh Tomar
{"title":"Mechanisms of DNA methylation and histone modifications.","authors":"Santoshi Acharjee,&nbsp;Shraddha Chauhan,&nbsp;Rajshree Pal,&nbsp;Raghuvir Singh Tomar","doi":"10.1016/bs.pmbts.2023.01.001","DOIUrl":"https://doi.org/10.1016/bs.pmbts.2023.01.001","url":null,"abstract":"<p><p>The field of genetics has expanded a lot in the past few decades due to the accessibility of human genome sequences, but still, the regulation of transcription cannot be explicated exclusively by the sequence of DNA of an individual. The coordination and crosstalk between chromatin factors which are conserved is indispensable for all living creatures. The regulation of gene expression has been dependent on the methylation of DNA, post-translational modifications of histones, effector proteins, chromatin remodeler enzymes that affect the chromatin structure and function, and other cellular activities such as DNA replication, DNA repair, proliferation and growth. The mutation and deletion of these factors can lead to human diseases. Various studies are being performed to identify and understand the gene regulatory mechanisms in the diseased state. The information from these high throughput screening studies is able to aid the treatment developments based on the epigenetics regulatory mechanisms. This book chapter will discourse on various modifications and their mechanisms that take place on histones and DNA that regulate the transcription of genes.</p>","PeriodicalId":21157,"journal":{"name":"Progress in molecular biology and translational science","volume":"197 ","pages":"51-92"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9264662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Synthetic receptors in medicine. 医学上的合成受体。
3区 生物学
Progress in molecular biology and translational science Pub Date : 2023-01-01 DOI: 10.1016/bs.pmbts.2022.09.011
Sarita Mishra, Mahima Raval, Vijai Singh, Anand Krishna Tiwari
{"title":"Synthetic receptors in medicine.","authors":"Sarita Mishra,&nbsp;Mahima Raval,&nbsp;Vijai Singh,&nbsp;Anand Krishna Tiwari","doi":"10.1016/bs.pmbts.2022.09.011","DOIUrl":"https://doi.org/10.1016/bs.pmbts.2022.09.011","url":null,"abstract":"<p><p>Cellular signaling is controlled by ligand receptor interaction and subsequent biochemical changes inside the cell. Manipulating receptors as per need that can be a strategy to alter the disease pathologies in various conditions. With recent advances in synthetic biology, now it is possible to engineer the artificial receptor \"synthetic receptors.\" Synthetic receptors are the engineering receptors that have potential to alter the disease pathology by altering/manipulating the cellular signaling. Several synthetic receptors are being engineered that have shown positive regulation in several disease conditions. Thus, synthetic receptor-based strategy opens a new avenue in the medical field to cope up with various health issues. The current chapter summarizes updated information about the synthetic receptors and their applications in the medical field.</p>","PeriodicalId":21157,"journal":{"name":"Progress in molecular biology and translational science","volume":"196 ","pages":"303-335"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9084486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
The endocytosis, trafficking, sorting and signaling of neurotrophic receptors. 神经营养受体的内吞、转运、分类和信号传导。
3区 生物学
Progress in molecular biology and translational science Pub Date : 2023-01-01 DOI: 10.1016/bs.pmbts.2022.06.033
Katja Burk
{"title":"The endocytosis, trafficking, sorting and signaling of neurotrophic receptors.","authors":"Katja Burk","doi":"10.1016/bs.pmbts.2022.06.033","DOIUrl":"https://doi.org/10.1016/bs.pmbts.2022.06.033","url":null,"abstract":"<p><p>Neurotrophins are soluble factors secreted by neurons themselves as well as by post-synaptic target tissues. Neurotrophic signaling regulates several processes such as neurite growth, neuronal survival and synaptogenesis. In order to signal, neurotrophins bind to their receptors, the tropomyosin receptor tyrosine kinase (Trk), which causes internalization of the ligand-receptor complex. Subsequently, this complex is routed into the endosomal system from where Trks can start their downstream signaling. Depending on their endosomal localization, co-receptors involved, but also due to the expression patterns of adaptor proteins, Trks regulate a variety of mechanisms. In this chapter, I provide an overview of the endocytosis, trafficking, sorting and signaling of neurotrophic receptors.</p>","PeriodicalId":21157,"journal":{"name":"Progress in molecular biology and translational science","volume":"196 ","pages":"141-165"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9092055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Endocytosis of dopamine receptor: Signaling in brain. 多巴胺受体的内吞作用:大脑中的信号传导。
3区 生物学
Progress in molecular biology and translational science Pub Date : 2023-01-01 DOI: 10.1016/bs.pmbts.2022.09.005
Ichiro Kawahata, Kohji Fukunaga
{"title":"Endocytosis of dopamine receptor: Signaling in brain.","authors":"Ichiro Kawahata,&nbsp;Kohji Fukunaga","doi":"10.1016/bs.pmbts.2022.09.005","DOIUrl":"https://doi.org/10.1016/bs.pmbts.2022.09.005","url":null,"abstract":"<p><p>This chapter describes the physiological significance of dopamine receptor endocytosis and the consequence of the receptor signaling. Endocytosis of dopamine receptors is regulated by many components such as clathrin, β-arrestin, caveolin, and Rab family proteins. The dopamine receptors escape from lysosomal digestion, and their recycling occurs rapidly, reinforcing the dopaminergic signal transduction. In addition, the pathological impact of the receptors interacting with specific proteins has been the focus of much attention. Based on this background, this chapter provides an in-depth understanding of the mechanisms of molecules interacting with dopamine receptors and discusses the potential pharmacotherapeutic targets for α-synucleinopathies and neuropsychiatric disorders.</p>","PeriodicalId":21157,"journal":{"name":"Progress in molecular biology and translational science","volume":"196 ","pages":"99-111"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9092063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Epigenetics of neurological diseases. 神经系统疾病的表观遗传学。
3区 生物学
Progress in molecular biology and translational science Pub Date : 2023-01-01 DOI: 10.1016/bs.pmbts.2023.01.006
Ozasvi R Shanker, Sonali Kumar, Aparna Banerjee Dixit, Jyotirmoy Banerjee, Manjari Tripathi, P Sarat Chandra
{"title":"Epigenetics of neurological diseases.","authors":"Ozasvi R Shanker,&nbsp;Sonali Kumar,&nbsp;Aparna Banerjee Dixit,&nbsp;Jyotirmoy Banerjee,&nbsp;Manjari Tripathi,&nbsp;P Sarat Chandra","doi":"10.1016/bs.pmbts.2023.01.006","DOIUrl":"https://doi.org/10.1016/bs.pmbts.2023.01.006","url":null,"abstract":"<p><p>Higher-order DNA structure and gene expression are governed by epigenetic processes like DNA methylation and histone modifications. Abnormal epigenetic mechanisms are known to contribute to the emergence of numerous diseases, including cancer. Historically, the chromatin abnormalities were only considered to be limited to discrete DNA sequences and were thought to be associated with rare genetic syndrome however, recent discoveries have pointed to genome-wide level changes in the epigenetic machinery which has contributed to a better knowledge of the mechanisms underlying developmental and degenerative neuronal problems associated with diseases such as Parkinson's disease, Huntington's disease, Epilepsy, Multiple sclerosis, etc. In the given chapter we describe the epigenetic alterations seen in various neurological disorders and further discuss the influence of these epigenetic changes on developing novel therapies.</p>","PeriodicalId":21157,"journal":{"name":"Progress in molecular biology and translational science","volume":"198 ","pages":"165-184"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9631487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cardiac cell sheet engineering for regenerative medicine and tissue modeling. 用于再生医学和组织建模的心脏细胞片工程。
3区 生物学
Progress in molecular biology and translational science Pub Date : 2023-01-01 Epub Date: 2023-06-17 DOI: 10.1016/bs.pmbts.2023.03.003
Katsuhisa Matsuura, Tatsuya Shimizu
{"title":"Cardiac cell sheet engineering for regenerative medicine and tissue modeling.","authors":"Katsuhisa Matsuura,&nbsp;Tatsuya Shimizu","doi":"10.1016/bs.pmbts.2023.03.003","DOIUrl":"10.1016/bs.pmbts.2023.03.003","url":null,"abstract":"<p><p>Stem cell biology and tissue engineering are essential techniques for cardiac tissue construction. We have succeeded in fabricating human cardiac tissue using the mass production technology of human iPS cell-derived cardiomyocytes and cell sheet engineering, and we are developing regenerative medicine and tissue models to apply this tissue to heart disease research. Cardiac tissue fabrication and tissue functional evaluation technologies for contractile and electrophysiological function are indispensable, which lead to the functional improvement of bioengineered human cardiac tissue.</p>","PeriodicalId":21157,"journal":{"name":"Progress in molecular biology and translational science","volume":"199 ","pages":"179-197"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10199866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Stem cell culture and differentiation in 3-D scaffolds. 干细胞在三维支架中的培养和分化。
3区 生物学
Progress in molecular biology and translational science Pub Date : 2023-01-01 Epub Date: 2023-07-26 DOI: 10.1016/bs.pmbts.2023.04.009
Yasuhiko Tabata, Idaszek Joanna, Akon Higuchi
{"title":"Stem cell culture and differentiation in 3-D scaffolds.","authors":"Yasuhiko Tabata,&nbsp;Idaszek Joanna,&nbsp;Akon Higuchi","doi":"10.1016/bs.pmbts.2023.04.009","DOIUrl":"10.1016/bs.pmbts.2023.04.009","url":null,"abstract":"<p><p>Conventional two-dimensional (2-D) cultivation are easy to utilize for human pluripotent stem (hPS) cell cultivation in standard techniques and are important for analysis or development of the signal pathways to keep pluripotent state of hPS cells cultivated on 2-D cell culture materials. However, the most efficient protocol to prepare hPS cells is the cell culture in a three dimensional (3-D) cultivation unit because huge numbers of hPS cells should be utilized in clinical treatment. Some 3-D cultivation strategies for hPS cells are considered: (a) microencapsulated cell cultivation in suspended hydrogels, (b) cell cultivation on microcarriers (MCs), (c) cell cultivation on self-aggregated spheroid [cell aggregates; embryoid bodies (EBs) and organoids], (d) cell cultivation on microfibers or nanofibers, and (e) cell cultivation in macroporous scaffolds. These cultivation ways are described in this chapter.</p>","PeriodicalId":21157,"journal":{"name":"Progress in molecular biology and translational science","volume":"199 ","pages":"109-127"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10239056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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