Biotechnological applications of amyloid fibrils.

3区 生物学 Q2 Biochemistry, Genetics and Molecular Biology
Mohsen Nabi Afjadi, Fatemeh Aziziyan, Farnoosh Farzam, Bahareh Dabirmanesh
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引用次数: 0

Abstract

Protein aggregates and amyloid fibrils have special qualities and are used in a variety of biotechnological applications. They are extensively employed in bioremediation, biomaterials, and biocatalysis. Because of their capacity to encapsulate and release pharmaceuticals and their sensitivity to certain molecules, respectively, they are also used in drug delivery and biosensor applications. They have also demonstrated potential in the domains of food and bioremediation. Additionally, amyloid peptides have drawn interest in biological applications, especially in the investigation of illnesses like Parkinson's and Alzheimer's. The unique characteristics of amyloid fibrils, namely their mechanical strength and β-sheet structure, make them adaptable to a wide range of biotechnological uses. Even with their promise, one important factor to keep in mind before widely using modified amyloid materials is their potential toxicity. Thus, current research aims to overcome safety concerns while maximizing their potential.

淀粉样纤维的生物技术应用。
蛋白质聚集体和淀粉样纤维具有特殊的性质,可用于多种生物技术领域。它们被广泛应用于生物修复、生物材料和生物催化等领域。由于它们分别具有封装和释放药物的能力以及对某些分子的敏感性,它们还被用于药物输送和生物传感器应用。它们在食品和生物修复领域也显示出潜力。此外,淀粉样肽在生物领域的应用也引起了人们的兴趣,特别是在帕金森氏症和阿尔茨海默氏症等疾病的研究中。淀粉样蛋白纤维的独特特性,即机械强度和β-片状结构,使其能够适应广泛的生物技术用途。尽管改性淀粉样蛋白材料大有可为,但在广泛应用之前仍需注意一个重要因素,那就是它们的潜在毒性。因此,目前的研究旨在克服安全问题,同时最大限度地发挥它们的潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
6.90
自引率
0.00%
发文量
0
审稿时长
>12 weeks
期刊介绍: Progress in Molecular Biology and Translational Science (PMBTS) provides in-depth reviews on topics of exceptional scientific importance. If today you read an Article or Letter in Nature or a Research Article or Report in Science reporting findings of exceptional importance, you likely will find comprehensive coverage of that research area in a future PMBTS volume.
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