Progress in molecular biology and translational science最新文献_第9页

Delivery of therapeutic proteins to ocular tissues: Barriers, approaches, regulatory considerations and future perspectives. 治疗性蛋白向眼组织的输送：障碍、途径、调控考虑和未来展望。

3区生物学

Progress in molecular biology and translational science Pub Date : 2025-01-01 Epub Date: 2024-09-12 DOI: 10.1016/bs.pmbts.2024.08.003

Divyesh Harshadkumar Shastri

{"title":"Delivery of therapeutic proteins to ocular tissues: Barriers, approaches, regulatory considerations and future perspectives.","authors":"Divyesh Harshadkumar Shastri","doi":"10.1016/bs.pmbts.2024.08.003","DOIUrl":"10.1016/bs.pmbts.2024.08.003","url":null,"abstract":"The administration of therapeutic proteins directly to the eye is a major breakthrough in the treatment of several eye conditions. This chapter highlights the crucial significance of ocular therapies because of the widespread occurrence of vision-threatening disorders and the distinct difficulties presented by the eye's architecture and physiological limitations. Therapeutic proteins, known for their exceptional specificity and effectiveness, provide hopeful answers. However, they encounter various obstacles in their ocular distributions like tear film, corneal epithelium, and blood-retinal barrier etc. Formulation techniques and drug delivery technologies, such as nanotechnology, hydrogels, microneedles, liposomes, dendrimers, and polymeric nanoparticles are improving the stability, bioavailability, and targeted administration of proteins. Notwithstanding this progress, obstacles such as protein stability, immunogenicity, and patient compliance endure. Methods to address these challenges include improving permeability, formulating sustained release systems, applying non-invasive delivery techniques, and implementing tailored delivery strategies. Furthermore, it is essential to effectively navigate through regulatory routes, comprehensively grasp market factors, and successfully secure intellectual property to achieve successful commercialization of these new methods.","PeriodicalId":21157,"journal":{"name":"Progress in molecular biology and translational science","volume":"212 ","pages":"261-277"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143693147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Wearable biosensors and devices for lung function monitoring. 用于肺功能监测的可穿戴生物传感器和设备。

3区生物学

Progress in molecular biology and translational science Pub Date : 2025-01-01 Epub Date: 2025-05-20 DOI: 10.1016/bs.pmbts.2025.05.007

Saif Saad Fakhrulddin, Vaibhav Bhatt

{"title":"Wearable biosensors and devices for lung function monitoring.","authors":"Saif Saad Fakhrulddin, Vaibhav Bhatt","doi":"10.1016/bs.pmbts.2025.05.007","DOIUrl":"10.1016/bs.pmbts.2025.05.007","url":null,"abstract":"Biosensors and devices that are wearable and enable continuous monitoring of lung function are disrupting methods of tracking respiratory health outside conventional settings. These cutting-edge technologies combine state-of-the-art sensors, flexible materials, and wireless connectivity to continuously monitor important respiratory metrics like oxygen saturation, breathing patterns, and lung volumes. They hold considerable promise in the eclipse of chronic respiratory diseases such as asthma and Chronic obstructive pulmonary disease (COPD), early detection of exacerbations, and individualization of treatment. Outside the clinical realm, these wearable biosensors provide actionable insights on improving respiratory efficiency and patterns that can be utilized in fitness optimization, rehabilitation, and sleep disorder management. Recent progress in sensor miniaturization, biocompatible materials, and data analytics has improved the comfort, accuracy, and ease of usability of these devices. Although these advantages exist, issues of motion artifacts, sensor calibration, and data security remain an ongoing challenge. What artificial intelligence and Internet of Things (IoT) allow us to do is break down these barriers, so no longer is it just a promise of predictive analytics and remote monitoring but actually a seamless possibility. Moreover, wearable biosensors may also be beneficial in public health programs as they allow large-scale collection and monitoring of individual health data at population levels during epidemics. As these devices progress, they will revolutionize respiratory healthcare by developing excellence in treatment, providing increased accessibility, and enabling proactive management of the disease.","PeriodicalId":21157,"journal":{"name":"Progress in molecular biology and translational science","volume":"215 ","pages":"355-384"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144668258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Next-generation biosensors for infectious disease surveillance: Innovations, challenges, and global health impact. 用于传染病监测的下一代生物传感器：创新、挑战和全球健康影响。

3区生物学

Progress in molecular biology and translational science Pub Date : 2025-01-01 Epub Date: 2025-06-09 DOI: 10.1016/bs.pmbts.2025.05.010

Nidhi Yadav, Ananya Tiwari, Alok Pandya, Shubhita Tripathi

{"title":"Next-generation biosensors for infectious disease surveillance: Innovations, challenges, and global health impact.","authors":"Nidhi Yadav, Ananya Tiwari, Alok Pandya, Shubhita Tripathi","doi":"10.1016/bs.pmbts.2025.05.010","DOIUrl":"10.1016/bs.pmbts.2025.05.010","url":null,"abstract":"Recent advances in next-generation biosensors are transforming on how infectious diseases are monitored and offering rapid, real-time, highly sensitive detection of pathogens. Emerging platforms such as wearable, ingestible, and implantable biosensors are enabling continuous health tracking and facilitating early diagnosis, which is critical in managing outbreaks and preventing disease progression. Innovations in nanotechnology, electrochemical sensing, and machine learning are further enhancing the precision, scalability, and affordability of these tools. Biosensors hold particular promise for infectious disease surveillance, especially in low-resource environments where traditional diagnostics may be slow, costly, or unavailable. These technologies can support timely outbreak response, antimicrobial resistance tracking, and personalized treatment strategies. Despite these promising developments, several challenges like regulatory approval processes, limited access to research funding, and difficulties in integrating new biosensing technologies into existing healthcare infrastructure continue to hinder widespread adoption. Overcoming these barriers will require interdisciplinary collaboration among engineers, clinicians, public health experts, and data scientists. This chapter explores key technological breakthroughs, implementation challenges, and the expanding role of biosensors in public health. It also examines future directions and opportunities for strengthening infectious disease monitoring systems to improve patient outcomes and reinforce global health resilience.","PeriodicalId":21157,"journal":{"name":"Progress in molecular biology and translational science","volume":"215 ","pages":"237-278"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144668256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Copyright 版权

3区生物学

Progress in molecular biology and translational science Pub Date : 2024-01-16 DOI: 10.1016/s1877-1173(24)00010-3

引用次数: 0

Index 索引

3区生物学

Progress in molecular biology and translational science Pub Date : 2024-01-16 DOI: 10.1016/s1877-1173(24)00014-0

引用次数: 0

Half Title Page 半扉页

3区生物学

Progress in molecular biology and translational science Pub Date : 2024-01-16 DOI: 10.1016/s1877-1173(24)00008-5

引用次数: 0

Contributors 贡献者

3区生物学

Progress in molecular biology and translational science Pub Date : 2024-01-16 DOI: 10.1016/s1877-1173(24)00011-5

引用次数: 0

Title Page 标题页

3区生物学

Progress in molecular biology and translational science Pub Date : 2024-01-16 DOI: 10.1016/s1877-1173(24)00009-7

引用次数: 0

SARS-CoV-2 variant biology and immune evasion SARS-CoV-2 变异生物学和免疫逃避

3区生物学

Progress in molecular biology and translational science Pub Date : 2024-01-04 DOI: 10.1016/bs.pmbts.2023.11.007

Asiya Kamber Zaidi, Rohan Bir Singh

{"title":"SARS-CoV-2 variant biology and immune evasion","authors":"Asiya Kamber Zaidi, Rohan Bir Singh","doi":"10.1016/bs.pmbts.2023.11.007","DOIUrl":"https://doi.org/10.1016/bs.pmbts.2023.11.007","url":null,"abstract":"This chapter discusses the SARS-CoV-2 variants and their immune evasion strategies, shedding light on the dynamic nature of the COVID-19 pandemic. The ecological dynamics and viral evolution of SARS-CoV-2 are explored, considering carriers of infection, individual immunity profiles, and human movement as key factors in the emergence and dissemination of variants. The chapter discusses SARS-CoV-2 mutation, including mutation rate, substitution rate, and recombination, influencing genetic diversity and evolution.Transmission bottlenecks are highlighted as determinants of dominant variants during viral spread. The evolution phases of the pandemic are outlined, from limited early evolution to the emergence of notable changes like the D614G substitution and variants with heavy mutations. Variants of Concern (VOCs), including Alpha, Beta, Gamma, and the recent Omicron variant, are examined, with insights into inter-lineage and intra-lineage dynamics. The origin of VOCs and the Omicron variant is explored, alongside the role of the furin cleavage site (FCS) in variant emergence. The impact of structural and non-structural proteins on viral infectivity is assessed, as well as innate immunity evasion strategies employed by SARS-CoV-2 variants. The chapter concludes by considering future possibilities, including ongoing virus evolution, the need for surveillance, vaccine development, and public health measures.","PeriodicalId":21157,"journal":{"name":"Progress in molecular biology and translational science","volume":"95 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139474774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Epidemiology of COVID-19 COVID-19 的流行病学

3区生物学

Progress in molecular biology and translational science Pub Date : 2024-01-04 DOI: 10.1016/bs.pmbts.2023.09.002

Asiya Kamber Zaidi, Rohan Bir Singh

引用次数: 0