Progress in molecular biology and translational science最新文献

{"title":"Emerging biosensor technologies for obstructive sleep apnea: A comprehensive overview and future prospects.","authors":"Chih-Wei Tsai, Lydia Leung, Hung Tat Chen, Ka Cheung Kwok, Michelle Lee, Ambrose A Chiang","doi":"10.1016/bs.pmbts.2025.06.002","DOIUrl":"10.1016/bs.pmbts.2025.06.002","url":null,"abstract":"<p><p>Obstructive sleep apnea (OSA) is a pervasive disorder characterized by recurrent airway obstructions during sleep. OSA carries serious health risks, such as cardiovascular and cognitive impairments, and imposes a significant economic burden. This chapter provides a comprehensive overview of various biosensors currently employed for OSA detection, including in-lab polysomnography and flow-based home sleep apnea testing. It also explores cutting-edge OSA-detecting technologies that often leverage advanced, artificial intelligence-powered sensing modalities, encompassing photoplethysmography/peripheral arterial tonometry-based, sound-based, and respiratory effort-based wearables. Moreover, this chapter examines promising diagnostic and screening solutions, including airables, bed/mattress sensors, and smartphone sensors. It also delves into emerging sensing technologies currently under active investigation, including earables/hearables and remote PPG. This review serves as a practical guide to understanding the mechanisms, capabilities, limitations, and clinical evidence surrounding both modern and future sensors poised to revolutionize the landscape of OSA detection.</p>","PeriodicalId":21157,"journal":{"name":"Progress in molecular biology and translational science","volume":"216 ","pages":"185-232"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145024193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surface modified proteins and peptides for targeted drug delivery.","authors":"Vivek P Chavda, Disha Joshi","doi":"10.1016/bs.pmbts.2024.12.001","DOIUrl":"10.1016/bs.pmbts.2024.12.001","url":null,"abstract":"<p><p>Surface modification of proteins and peptides has emerged as a promising strategy to enhance their therapeutic efficacy and target specificity. This chapter delves into the various techniques employed to modify the surface properties of these biomolecules, including chemical conjugation, site-specific mutagenesis, and peptide synthesis. The focus is on strategies that improve drug delivery to specific target sites, such as tumor cells or inflamed tissues. By modifying surface properties, it is possible to enhance drug stability, reduce immunogenicity, and prolong circulation time. This chapter explores the latest advancements in this field and discusses the potential applications of surface-modified proteins and peptides in the development of novel therapeutic agents.</p>","PeriodicalId":21157,"journal":{"name":"Progress in molecular biology and translational science","volume":"212 ","pages":"389-438"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143693185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advancements in wearable electrochemical biosensors: The next generation of insulin detection devices.","authors":"Chochanon Moonla, Nuenghathai Chaiya, Itthipon Jeerapan","doi":"10.1016/bs.pmbts.2025.05.004","DOIUrl":"10.1016/bs.pmbts.2025.05.004","url":null,"abstract":"<p><p>Insulin resistance, characterized by an impaired biological response to insulin stimulation in target tissues, primarily affects the muscle, liver, and adipose tissue. This dysfunction impairs glucose disposal, triggering compensatory β-cell insulin overproduction and resulting in hyperinsulinemia. Its metabolic consequences include hypertension, hyperglycemia, hyperuricemia, dyslipidemia, elevated inflammatory markers, prothrombotic state, and endothelial dysfunction. One of the most significant issues is type 2 diabetes (T2D), which is preceded by insulin resistance (IR) for an estimated 10-15 years. Addressing the challenges of insulin detection requires a multidisciplinary approach, including advancements in wearable electrochemical biosensors for real-time insulin monitoring. This chapter explores the physiological role of insulin, the history and challenges of insulin detection, and the latest developments in sensing technologies. We discuss emerging innovations with significant healthcare applications, particularly in point-of-care testing (POCT) and telemedicine. Additionally, we highlight translational gaps and the barriers to integrating novel detection technologies into clinical practice. Continued interdisciplinary collaboration and technological innovation are crucial for enhancing insulin detection, improving long-term outcomes, and advancing personalized healthcare. Wearable biosensors, as cutting-edge analytical tools, offer transformative opportunities for biomedical and translational research, fostering proactive lifestyle, nutrition, and medical interventions.</p>","PeriodicalId":21157,"journal":{"name":"Progress in molecular biology and translational science","volume":"215 ","pages":"385-403"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144668251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Engineering aspects and materials for next generation neural implants.","authors":"Kuldeep Mahato","doi":"10.1016/bs.pmbts.2025.07.001","DOIUrl":"10.1016/bs.pmbts.2025.07.001","url":null,"abstract":"<p><p>Nano-electronics based neural implants represent a rapidly advancing interdisciplinary domain at the intersection of bioelectronics, nanotechnology, and neuro-engineering. These implantable systems are engineered to restore, modulate, or augment neural functions by establishing high-fidelity, long-term interfaces with neural tissues. The design of such implants necessitates careful consideration of both materials and structural configurations to ensure biocompatibility, mechanical compliance, electrical functionality, and chronic stability. Recent innovations in nanomaterials including graphene, carbon nanotubes, and conductive polymers have significantly enhanced the bio-integration and functional longevity of these devices. Furthermore, the incorporation of soft hydrogels, nanostructured coatings, and stretchable electronic platforms mitigates immune responses and supports intimate neural contact. On the system level, design strategies prioritize miniaturization, wireless communication, and energy-efficient architectures, enabling real-time monitoring and closed-loop neuromodulation. Multimodal capabilities-combining sensing, stimulation, and drug delivery-further augment the therapeutic potential of these implants for managing complex neurological conditions such as Parkinson's disease, epilepsy, and spinal cord injuries. This review outlines the critical materials and engineering principles underpinning the development of bio-nano-electronic neural implants, emphasizing their role in advancing personalized neurotherapeutics and improving patient outcomes. The integration of smart materials with neural interface technologies holds substantial promise for enhancing the quality of life in individuals affected by neurological dysfunction.</p>","PeriodicalId":21157,"journal":{"name":"Progress in molecular biology and translational science","volume":"216 ","pages":"313-349"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145024157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Peptide pharmacology: Pioneering interventions for alcohol use disorder.","authors":"Ramkumar Katturajan, Sabina Evan Prince, Abilash Valsala Gopalakrishnan","doi":"10.1016/bs.pmbts.2024.05.003","DOIUrl":"10.1016/bs.pmbts.2024.05.003","url":null,"abstract":"<p><p>Alcohol use disorder (AUD) is a substantial public health issue, with few treatment choices and a high social cost. This review investigates the possibility of peptide pharmacology as a new treatment for AUD. Peptides, or short chains of amino acids, provide specific manipulation of neuronal pathways involved in addiction, such as the opioid, corticotropin-releasing factor (CRF), neuropeptide Y (NPY), and glutamate systems. Preclinical research has shown that peptide-based therapies can reduce alcohol intake, demand, and relapse in animal models of AUD. Opioid peptides like β-endorphin and enkephalins affect alcohol reward processing by interacting with µ, ∂, and κ opioid receptors. CRF peptides reduce stress-induced alcohol-seeking behavior by targeting the dysregulated CRF system. NPY and associated peptides reduce cravings and anxiety by regulating stress and emotional processing. Peptide-based therapies have strong translational potential, as evidenced by early clinical trial results. There are also challenges in converting preclinical discoveries into clinical practice, such as establishing the safety, tolerability, and effectiveness of peptide therapies in humans. Future initiatives include identifying new peptide targets, optimizing pharmacokinetics, and incorporating peptide-based therapies into established therapy methods. Overall, peptide pharmacology represents a potential prospect in AUD therapy, as it provides tailored therapies that address the complex neurobiological pathways that underpin addiction.</p>","PeriodicalId":21157,"journal":{"name":"Progress in molecular biology and translational science","volume":"212 ","pages":"117-128"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143693153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Wearable biosensing devices for mental health, wellness, and stress management.","authors":"Vivian Genaro Motti, Farina Faiz","doi":"10.1016/bs.pmbts.2025.06.003","DOIUrl":"10.1016/bs.pmbts.2025.06.003","url":null,"abstract":"<p><p>Data gathering for diagnostic purposes often relies on psychological instruments and validated tests applied individually through in person interviews. Such an approach is limited since it relies on a subjective perception of the individual as well as their abilities to recall information concerning their behaviors, thoughts, and feelings. Thus, the accuracy of the assessment tends to be unreliable and prone to bias, stigma, as well as subjective interpretations. Moreover, psychological instruments (such as questionnaires) are often created and validated for a specific population. However, socio-demographic differences, along with cultural, environmental, and educational aspects, are factors that strongly influence the reliability of tests and their results. On the other hand, wearable technology has a promising potential to address such limitations, being well suited for mental health applications. Wearables are capable of capturing physiological and behavioral measures from human users, reducing subjectivity in this process. Wearable biosensing devices are also particularly useful for capturing users' data longitudinally in a non-invasive and unobtrusive way. Physiological data from wearable sensors includes pulse rate, skin conductance, skin temperature, cortisol levels, and respiration rate. Wearable sensors can also detect behavioral data such as sleep patterns, physical activity, and social interactions. These data points combined have proven to be highly effective in detecting an individual's stress, attention, and mood. Hence, studies in mental health, wellness, and stress have increasingly adopted wearable technologies. This chapter provides a comprehensive review of wearable devices and their widespread application for mental health, wellness, and stress management. We cover various form factors, sensors, data analysis techniques and real-world applications. We conclude with a discussion about the best practices, design considerations and future directions to deploy wearable applications that are ethical and fair for users.</p>","PeriodicalId":21157,"journal":{"name":"Progress in molecular biology and translational science","volume":"216 ","pages":"233-254"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145024186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterization of skeletal muscle contraction using a flexible and wearable ultrasonic sensor.","authors":"Elliot Yeung, Ibrahim AlMohimeed, Yuu Ono","doi":"10.1016/bs.pmbts.2025.06.001","DOIUrl":"10.1016/bs.pmbts.2025.06.001","url":null,"abstract":"<p><p>Monitoring skeletal muscle contraction provides valuable information about the muscle mechanical properties, which can be helpful in various biomedical applications. This chapter presents a single-element flexible and wearable ultrasonic sensor (WUS) developed by our research group and its application for continuously monitoring and characterizing skeletal muscle contraction. The WUS is made from a 110-µm thick polyvinylidene fluoride piezoelectric polymer film. The lightweight and flexible properties of the WUS enable stable attachment to a skin surface without impacting the tissue motion of interest beneath the WUS. As an example of in-vivo demonstrations of muscle contraction monitoring and characterization, continuous monitoring of muscle contraction of the lateral head of the triceps muscle in healthy human subjects is performed using the WUS in the ultrasound pulse-echo technique. The changes in tissue thickness caused by muscle contraction evoked by electromyostimulation (EMS) at different EMS pulse repetition frequencies are measured using an ultrasound time-of-flight method. The muscle contractile parameters are estimated using the muscle twitches obtained at an EMS frequency of 2 Hz, where the muscle can fully relax between consecutive twitches. Furthermore, a level of tetanic progression, where the muscle cannot completely relax, is quantitatively assessed using the fusion index (FI), estimated from the changes in tissue thickness at EMS frequencies ranging from 2 Hz to 30 Hz, with an increment of 2 Hz. It is demonstrated that the unfused and fused tetanus frequencies can be estimated from the FI frequency curve and the contractile parameters obtained at 2 Hz. The WUS and ultrasonic methods demonstrated in this study could be valuable for non-invasive, continuous monitoring of skeletal muscle contractile properties.</p>","PeriodicalId":21157,"journal":{"name":"Progress in molecular biology and translational science","volume":"216 ","pages":"87-107"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145024190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ingestible biosensors for drug delivery monitoring.","authors":"Niha Ansari, Jeet Dasgupta, Divyant Jain","doi":"10.1016/bs.pmbts.2025.06.009","DOIUrl":"10.1016/bs.pmbts.2025.06.009","url":null,"abstract":"<p><p>Ingestible biosensors are a mix of advanced biomedical engineering, digital health and precision pharmacotherapy. These miniaturised electronic devices are encapsulated in biocompatible materials, which operate within gastrointestinal (GI) tract. This enables real-time monitoring of pharmacological and physiological parameters. The development of modern FDA-approved platforms such as SmartPillTM and IntelliCapTM, from early radio pills, has been outlined, showing the advancements in sensor integration, wireless telemetry and microelectronics. The main purpose of such pills includes detection of pharmacokinetic profiles, monitoring of metabolic biomarkers like glucose, lactate and volatile gases and verification of real-time medication ingestion. Such kind of applications are critical in behavioural medicine, forensic toxicology, clinical pharmacology and chronic disease management. The chapter discusses core engineering aspects of a capsule, such as data transmission technology, sensor modules and power systems. Advancements such as biodegradable capsules, AI-integrated analytical platforms and biofuel-powered sensors are discussed in relation to next-generation health care systems. Every advance technology comes its fair share of challenges such as power limitations, patient acceptance, signal attenuation and ethical concerns surrounding data privacy. Predictive diagnostics and decentralised care are also analysed, keeping in view the merger of biosensor data with AI and Big Data platforms. The chapter concludes by focusing on possible contributions of ingestible biosensors in the frontier of personalized and preventive medicine, this can redefine diagnostics, drug delivery and remote monitoring. These devices will transition from clinical novelty to standard instruments for care for various therapeutic landscapes.</p>","PeriodicalId":21157,"journal":{"name":"Progress in molecular biology and translational science","volume":"216 ","pages":"373-387"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145024144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biomarkers in wearables, ingestible, and implantable sensors for health monitoring.","authors":"Gairika Ghosh, Ravish Sharma","doi":"10.1016/bs.pmbts.2025.05.015","DOIUrl":"10.1016/bs.pmbts.2025.05.015","url":null,"abstract":"<p><p>Biomarkers are vital indicators of biological processes and play a key role in diagnostics and personalized medicine. This chapter discusses the classification of biomarkers and presents an overview of biosensing technologies developed for their detection through wearable, ingestible, and implantable sensor platforms. Wearable sensors mainly track physiological signals, such as heart rate and temperature, and are increasingly capable of detecting biochemical markers in sweat or interstitial fluid. Ingestible sensors provide non-invasive access to the gastrointestinal tract, detecting biomarkers like pH, gases, and metabolites to assess systemic health. Implantable sensors, integrated into body tissues, enable long-term, high-resolution monitoring of internal biomarkers. The future of biosensing lies in multi-modal platforms that combine various sensing technologies with AI-driven data analysis to enhance diagnostic precision and support personalized treatments. However, despite significant advancements, several challenges remain, including ensuring sensor biocompatibility, managing power requirements, securing health data, navigating regulatory approvals, and addressing ethical concerns. Overcoming these barriers is essential for successful clinical translation and broader commercialization.</p>","PeriodicalId":21157,"journal":{"name":"Progress in molecular biology and translational science","volume":"215 ","pages":"35-62"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144668254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Introduction to emerging biosensing technologies.","authors":"Malvika Shukla, Kuldeep Mahato, Alok Pandya","doi":"10.1016/bs.pmbts.2025.05.013","DOIUrl":"10.1016/bs.pmbts.2025.05.013","url":null,"abstract":"<p><p>Wearable biosensors offer real-time, non-invasive monitoring of vital physiological and biochemical signals, transforming the landscape of personalized healthcare. This chapter outlines the components and the ideal requirements for usability, such as flexibility, comfort, and biocompatibility. They are employed in diverse applications such as chronic disease management, including diabetes, respiratory conditions, neurological disorders, cancer detection, infectious disease tracking, and stress monitoring. These sensors support early diagnosis, continuous monitoring, and personalized treatment strategies. The integration of artificial intelligence enhances data interpretation, enabling predictive insights and real-time alerts. However, with increased data collection comes the need for strong privacy and security protections. Wearable biosensors hold significant promise in reshaping healthcare by enabling proactive, data-driven decision-making and improving health outcomes through continuous and personalized monitoring, which has been highlighted in this chapter.</p>","PeriodicalId":21157,"journal":{"name":"Progress in molecular biology and translational science","volume":"215 ","pages":"1-33"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144668255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}