Progress in molecular biology and translational science最新文献_第7页

Artificial intelligence and machine learning heuristics for discovery of ncRNAs. 人工智能和机器学习启发式发现ncrna。

3区生物学

Progress in molecular biology and translational science Pub Date : 2025-01-01 Epub Date: 2025-01-22 DOI: 10.1016/bs.pmbts.2025.01.002

Alfredo Benso, Gianfranco Politano

引用次数: 0

Non-coding RNAs and their integrated biological networks. 非编码rna及其整合的生物网络。

3区生物学

Progress in molecular biology and translational science Pub Date : 2025-01-01 Epub Date: 2025-06-06 DOI: 10.1016/bs.pmbts.2025.05.014

Bilal Ahmed Abbasi, Renuka Suravajhala, V S Sundararajan, Jayaraman Valadi, Prashanth Suravajhala

引用次数: 0

Wearable biosensors for autoimmune disorders. 用于自身免疫性疾病的可穿戴生物传感器

3区生物学

Progress in molecular biology and translational science Pub Date : 2025-01-01 Epub Date: 2025-05-19 DOI: 10.1016/bs.pmbts.2025.05.008

Jyot Thesia, Alok Pandya

{"title":"Wearable biosensors for autoimmune disorders.","authors":"Jyot Thesia, Alok Pandya","doi":"10.1016/bs.pmbts.2025.05.008","DOIUrl":"10.1016/bs.pmbts.2025.05.008","url":null,"abstract":"Millions of people are affected worldwide by autoimmune disorders, including rheumatoid arthritis, lupus, multiple sclerosis and others, whose immune attacks also do not occur in a straightforward or stable manner. Dynamic changes of disease progression and treatment efficacy are not regularly monitored or diagnosed using conventional diagnostic and monitoring techniques. Wearable biosensors (WBS) provide a transformational solution for continuous, minimally invasive biomarker monitoring including cytokines, autoantibodies and acute phase proteins. This paper reviews the pathophysiology underlying WBS in autoimmune disease management, the relevant biomarkers, and the recent advances in biosensor technology. Sensitivity, specificity, stability and biocompatibility issues have also been addressed. Towards the future, our vision includes future prospects in big data analytics and artificial intelligence for predictive modeling, material science advancements for improving sensor performance, noninvasive monitoring technologies, and omics integration for a complete health status of the patient. These innovations have the ability to affect patients suffering from autoimmune disease in a personalized, data driven, and real time manner.","PeriodicalId":21157,"journal":{"name":"Progress in molecular biology and translational science","volume":"215 ","pages":"405-418"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144668259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Targeting MYC with protein drugs. 用蛋白药物靶向MYC。

3区生物学

Progress in molecular biology and translational science Pub Date : 2025-01-01 Epub Date: 2024-07-19 DOI: 10.1016/bs.pmbts.2024.07.001

Jumi A Shin

引用次数: 0

Climate change, health, and wearable biosensors: Harnessing emerging technologies to bridge environmental exposures and physiological responses. 气候变化、健康和可穿戴生物传感器：利用新兴技术弥合环境暴露和生理反应。

3区生物学

Progress in molecular biology and translational science Pub Date : 2025-01-01 Epub Date: 2025-07-22 DOI: 10.1016/bs.pmbts.2025.06.010

Nour Kassem, Perla Boutros, Sandra Barteit

{"title":"Climate change, health, and wearable biosensors: Harnessing emerging technologies to bridge environmental exposures and physiological responses.","authors":"Nour Kassem, Perla Boutros, Sandra Barteit","doi":"10.1016/bs.pmbts.2025.06.010","DOIUrl":"10.1016/bs.pmbts.2025.06.010","url":null,"abstract":"Climate change poses a growing threat to human health, increasing exposure to extreme environmental conditions. Wearable biosensors provide real-time monitoring of physiological responses to heat stress, including cardiovascular strain, thermoregulatory disruptions, sleep disturbances, and biomarkers of heat-related illnesses. These devices also assess behavioural adaptations, such as reduced physical activity, offering insights into physiological resilience and susceptibility. Wearable biosensors have broad applications in occupational health, enabling non-invasive detection of heat-related illnesses and the monitoring of air pollution impacts on respiratory and cardiovascular function. Validation studies emphasise the importance of sensor placement and multimodal analytics to enhance measurement accuracy under extreme conditions. By synchronising environmental and biometric data, these technologies support ecological momentary assessment, informing evidence-based policymaking and personalised health interventions. Despite their potential, challenges remain in ensuring equitable deployment, particularly in resource-limited settings. Issues such as affordability, data privacy, and validation across diverse populations must be addressed to enable widespread adoption. As climate change intensifies, integrating wearable biosensors into public health frameworks and adaptation policies will be essential for mitigating health risks and enhancing resilience in vulnerable populations.","PeriodicalId":21157,"journal":{"name":"Progress in molecular biology and translational science","volume":"216 ","pages":"109-137"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145024177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Epigenetic and experimental approaches influencing non-coding RNAs. 影响非编码rna的表观遗传学和实验方法。

3区生物学

Progress in molecular biology and translational science Pub Date : 2025-01-01 Epub Date: 2025-06-06 DOI: 10.1016/bs.pmbts.2025.05.001

Urvashi Vijay, Ashmeet Kaur, Sunil Polipalli

{"title":"Epigenetic and experimental approaches influencing non-coding RNAs.","authors":"Urvashi Vijay, Ashmeet Kaur, Sunil Polipalli","doi":"10.1016/bs.pmbts.2025.05.001","DOIUrl":"10.1016/bs.pmbts.2025.05.001","url":null,"abstract":"Epigenetics having sundry ambiences which are robustly linked to non-coding RNAs, precisely small RNAs that are generally imputated in gene expression regulation and helps in directing cytosine methylation and histone modifications of complex organisms. A pivotal peculiarity of epigenetics is that the same genome shows unwonted phenotypes which are situated in different epigenetics states. In last decade, the majority tangled epigenetic phenomena studied encompasses transposon activity and silencing which are directly or indirectly associated in RNA component and are currently epitomize by piRNAs (piwi-interacting RNAs), position effect variegation, X-chromosome inactivation, parental imprinting, and paramutation. Envisagly, there are certain non - coding RNAs are players in epigenetics gene regulation but their mechanism is still underlying. In yeast, plants, and mice, ncRNAs facilitate the inheritance of epigenetic states, effectively transmitting information across generations. This transgenerational epigenetic inheritance underscores the potential of ncRNAs to act as carriers of heritable information, bridging the gap between environmental cues and genetic responses. In conclusion, ncRNAs play a central role in epigenetic regulation and the transfer of genetic information, highlighting their importance in the evolution and complexity of higher organisms. In this review article, ongoing research continues to uncover the multifaceted functions of these molecules, offering deeper insights into the regulatory architectures that underpin life.","PeriodicalId":21157,"journal":{"name":"Progress in molecular biology and translational science","volume":"214 ","pages":"65-79"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144340381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring the critical role of non-coding RNAs in plant development and stress adaptation-current status and insights. 探索非编码rna在植物发育和逆境适应中的关键作用-现状和见解。

3区生物学

Progress in molecular biology and translational science Pub Date : 2025-01-01 Epub Date: 2025-02-06 DOI: 10.1016/bs.pmbts.2025.01.003

Nilesh Wagh, Pranav Amane, Rahul Kshirsagar, Sayanti Mandal, P B Kavi Kishor, Penna Suprasanna

{"title":"Exploring the critical role of non-coding RNAs in plant development and stress adaptation-current status and insights.","authors":"Nilesh Wagh, Pranav Amane, Rahul Kshirsagar, Sayanti Mandal, P B Kavi Kishor, Penna Suprasanna","doi":"10.1016/bs.pmbts.2025.01.003","DOIUrl":"10.1016/bs.pmbts.2025.01.003","url":null,"abstract":"Non-coding RNAs (ncRNAs), a major fraction of the genome earlier considered as transcriptomic noise has now been uncovered as functional regulators over the past decade. NcRNAs are recognized for their structural and regulatory role in intricate network of plant development and stress response, offering novel insights into molecular mechanisms underlying plant resilience. Advanced sequencing technologies have facilitated the identification and characterization of ncRNAs, highlighting their significance in plant growth, development, and stress responses. This review comprehensively addresses the varied roles of ncRNAs in orchestrating stress perception and response with a brief introduction of various classes of ncRNAs. Further, mode of action and mechanistic role of ncRNAs in modulating genetic regulation of stress response are discussed, along with the role of various ncRNA involved in regulating plant architectural changes. The ncRNA are currently exploited for developing stress-resilient crop varieties with improved yield, especially in the context of global climate change and food security. By integrating molecular perspectives with practical implications, this review offers a thorough understanding of how ncRNAs contribute to plant stress responses, paving the way for innovative strategies in crop improvement and sustainable agriculture.","PeriodicalId":21157,"journal":{"name":"Progress in molecular biology and translational science","volume":"214 ","pages":"19-64"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144340382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preface. 前言。

3区生物学

Progress in molecular biology and translational science Pub Date : 2025-01-01 DOI: 10.1016/S1877-1173(25)00136-X

Alok Pandya, Kuldeep Mahato

引用次数: 0

Peptide-based inhibitors of epigenetic proteins. 基于肽的表观遗传蛋白抑制剂。

3区生物学

Progress in molecular biology and translational science Pub Date : 2025-01-01 Epub Date: 2024-06-25 DOI: 10.1016/bs.pmbts.2024.04.004

Jordi C J Hintzen, Jasmin Mecinović

{"title":"Peptide-based inhibitors of epigenetic proteins.","authors":"Jordi C J Hintzen, Jasmin Mecinović","doi":"10.1016/bs.pmbts.2024.04.004","DOIUrl":"10.1016/bs.pmbts.2024.04.004","url":null,"abstract":"Epigenetic drug discovery has become an integral part of medicinal chemistry in the past two decades. Targeting epigenetic proteins-enzymes that modify histone proteins and DNA (writers and erasers) and proteins that recognize such modifications (readers)-has been firmly established as a medicinal strategy for treatment of many human diseases, including cancer and neurological disorders. In this chapter, we systematically describe peptide-based inhibitors of structurally and functionally diverse classes of epigenetic proteins. We show that epigenetic writers, such as DNA methyltransferases, histone methyltransferases and histone acetyltransferases, can be efficiently inhibited by peptides possessing nonproteinogenic amino acids. Moreover, the activity of epigenetic erasers, including TET enzymes, histone demethylases, and histone deacetylases, can be selectively modulated by diverse linear and cyclic peptides. Furthermore, we discuss chromatin-binding epigenetic reader proteins that can be inhibited by histone-mimicking peptides. Overall, this chapter highlights that peptides provide an important molecular platform for epigenetic drug discovery programmes in academia and industry.","PeriodicalId":21157,"journal":{"name":"Progress in molecular biology and translational science","volume":"212 ","pages":"25-65"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143693155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Wearable sensors for animal health and wellness monitoring. 用于动物健康监测的可穿戴传感器。

3区生物学

Progress in molecular biology and translational science Pub Date : 2025-01-01 Epub Date: 2025-07-28 DOI: 10.1016/bs.pmbts.2025.06.008

M R Krishnendu, Sanjay Singh

{"title":"Wearable sensors for animal health and wellness monitoring.","authors":"M R Krishnendu, Sanjay Singh","doi":"10.1016/bs.pmbts.2025.06.008","DOIUrl":"10.1016/bs.pmbts.2025.06.008","url":null,"abstract":"Biosensors are rapidly emerging as a key tool in animal health management, therefore, gaining a significant recognition in the global market. Wearable sensors, integrated with advanced biosensing technologies, provide highly specialized devices for measuring both individual and multiple physiological parameters of animals, as well as monitoring their environment. These sensors are not only precise and sensitive but also reliable, user-friendly, and capable of accelerating the monitoring process. In livestock management, novel biosensors offer significant benefits in various areas, including disease detection, health monitoring, detection of reproductive cycles, and assessment of the overall physiological well-being of animals through environmental analysis. A wide range of advanced technologies are being applied in the development of wearable sensors, including microfluidics, fluorescence resonance energy transfer, surface plasmon resonance, image detection techniques, electrochemical sensing, cantilever-based sensing, and many others. The data generated from these integrated monitoring systems provides crucial insights into the biochemical, emotional, and physiological functions of farm animals. This not only helps identify the most productive animals but also enables farmers to predict which animals may be more resilient to common diseases. This chapter explores the various technological advancements used in wearable sensor development, digital animal health, and the different types of wearable sensors and their applications in livestock management.","PeriodicalId":21157,"journal":{"name":"Progress in molecular biology and translational science","volume":"216 ","pages":"139-183"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145024180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0