RNA therapeutics for infectious diseases.

3区生物学 Q2 Biochemistry, Genetics and Molecular Biology

Progress in molecular biology and translational science Pub Date : 2024-01-01 Epub Date: 2024-01-29 DOI:10.1016/bs.pmbts.2024.01.002

Le Minh Tu Phan, Thi Thuy Duong Pham, Van Thai Than

引用次数: 0

Abstract

Ribonucleic acids (RNAs), including the messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA), play important roles in living organisms and viruses. In recent years, the RNA-based technologies including the RNAs inhibiting other RNA activities, the RNAs targeting proteins, the RNAs reprograming genetic information, and the RNAs encoding therapeutical proteins, are useful methods to apply in prophylactic and therapeutic vaccines. In this review, we summarize and highlight the current application of the RNA therapeutics, especially on mRNA vaccines which have potential for prevention and treatment against human and animal infectious diseases.

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治疗传染病的 RNA 疗法。

核糖核酸（RNA），包括信使核糖核酸（mRNA）、转移核糖核酸（tRNA）和核糖体核糖核酸（rRNA），在生物体和病毒中发挥着重要作用。近年来，以 RNA 为基础的技术，包括抑制其他 RNA 活性的 RNA、靶向蛋白质的 RNA、重编程遗传信息的 RNA 和编码治疗用蛋白质的 RNA，都是应用于预防和治疗疫苗的有用方法。在这篇综述中，我们总结并重点介绍了目前 RNA 疗法的应用，尤其是在预防和治疗人类和动物传染病方面具有潜力的 mRNA 疫苗。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Progress in molecular biology and translational science 生物-生化与分子生物学

CiteScore

6.90

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Progress in Molecular Biology and Translational Science (PMBTS) provides in-depth reviews on topics of exceptional scientiﬁc importance. If today you read an Article or Letter in　Nature　or a Research Article or Report in　Science　reporting ﬁndings of exceptional importance, you likely will ﬁnd comprehensive coverage of that research area in a future　PMBTS　volume.