Long Covid

3区 生物学 Q2 Biochemistry, Genetics and Molecular Biology
Asiya Kamber Zaidi, Puya Dehgani-Mobaraki
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引用次数: 0

Abstract

Long COVID, also known as post-acute sequelae of SARS-CoV-2 infection (PASC), refers to a constellation of persistent symptoms and health issues that continue beyond the acute phase of COVID-19. This chapter provides an overview of the pathogenesis, risk factors, manifestations, major findings, and diagnosis and treatment strategies associated with Long COVID. Hypotheses regarding the pathogenesis of Long COVID are discussed, encompassing various factors such as persistent viral reservoirs, immune dysregulation with or without reactivation of herpesviruses (e.g., Epstein-Barr Virus and human herpesvirus), dysbiosis, autoimmunity triggered by infection, endothelial dysfunction, microvessel blood clotting, and dysfunctional brainstem and/or vagal signaling. The chapter also highlights the risk factors associated with Long COVID and its occurrence in children. The major findings of Long COVID, including immune dysregulation, vessel and tissue damage, neurological and cognitive pathology, eye symptoms, endocrinal issues, myalgic encephalomyelitis and chronic fatigue syndrome, reproductive system involvement, respiratory and gastrointestinal symptoms, and the chronology of symptoms, are thoroughly explored. Lastly, the chapter discusses the challenges and current approaches in the diagnosis and treatment of Long COVID, emphasizing the need for multidisciplinary care and individualized management strategies.

Long Covid
长COVID又称SARS-CoV-2感染急性后遗症(PASC),是指在COVID-19急性期过后仍持续存在的一系列症状和健康问题。本章概述了与COVID-19相关的发病机制、风险因素、表现、主要发现以及诊断和治疗策略。本章讨论了有关长COVID发病机制的各种假设,其中包括各种因素,如持续的病毒库、疱疹病毒(如爱泼斯坦-巴氏病毒和人类疱疹病毒)再活化或未再活化的免疫调节失调、菌群失调、感染引发的自身免疫、内皮功能障碍、微血管凝血以及脑干和/或迷走神经信号传导功能障碍。本章还强调了与长COVID相关的风险因素及其在儿童中的发生率。本章深入探讨了 Long COVID 的主要发现,包括免疫调节失调、血管和组织损伤、神经和认知病理、眼部症状、内分泌问题、肌痛性脑脊髓炎和慢性疲劳综合征、生殖系统受累、呼吸和胃肠道症状以及症状的时间顺序。最后,本章讨论了诊断和治疗长 COVID 所面临的挑战和当前的方法,强调了多学科护理和个性化管理策略的必要性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
6.90
自引率
0.00%
发文量
0
审稿时长
>12 weeks
期刊介绍: Progress in Molecular Biology and Translational Science (PMBTS) provides in-depth reviews on topics of exceptional scientific importance. If today you read an Article or Letter in Nature or a Research Article or Report in Science reporting findings of exceptional importance, you likely will find comprehensive coverage of that research area in a future PMBTS volume.
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