Progress in molecular biology and translational science最新文献_第3页

Advances in materials for wearable biosensors. 可穿戴生物传感器材料的研究进展。

3区生物学

Progress in molecular biology and translational science Pub Date : 2025-01-01 Epub Date: 2025-05-24 DOI: 10.1016/bs.pmbts.2025.05.009

Dhruvesh Maiya, Tvarit Patel, Alok Pandya

{"title":"Advances in materials for wearable biosensors.","authors":"Dhruvesh Maiya, Tvarit Patel, Alok Pandya","doi":"10.1016/bs.pmbts.2025.05.009","DOIUrl":"https://doi.org/10.1016/bs.pmbts.2025.05.009","url":null,"abstract":"Wearable biosensors have emerged as transformative instruments for continuous, non-invasive health monitoring, providing real-time analysis of biomarkers in biofluids such as sweat, interstitial fluid, and saliva. This chapter offers a comprehensive overview of the pivotal role of biomaterials in the design and functionality of wearable biosensors. It examines the selection criteria for biocompatible materials, emphasizing properties such as flexibility, stretchability, conductivity, and long-term stability. The discussion categorizes advanced materials, including hydrogels, polyurethanes, carbon-based nanomaterials, metallic nanoparticles, and microneedles, and evaluates their applications in biosensing platforms for glucose, pH, and metal ion detection. Through case studies and figure-integrated explanations, the chapter highlights innovations such as smart hydrogel contact lenses, self-powered alcohol biosensors, and closed-loop microneedle patches for autonomous insulin delivery. It further explores key challenges, including biofluid variability, sensor biocompatibility, and the correlation of biofluid biomarkers with blood concentrations. Finally, the chapter underscores future directions involving AI integration, federated learning, and next-generation biomaterials like biodegradable polymers and stretchable composites. By bridging materials science with digital health technologies, wearable biosensors are poised to revolutionize personalized medicine, enabling early diagnosis, disease prevention, and optimized therapeutic interventions.","PeriodicalId":21157,"journal":{"name":"Progress in molecular biology and translational science","volume":"215 ","pages":"155-179"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144668252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Wearable biosensors for cancer detection and monitoring. 用于癌症检测和监测的可穿戴生物传感器。

3区生物学

Progress in molecular biology and translational science Pub Date : 2025-01-01 Epub Date: 2025-05-24 DOI: 10.1016/bs.pmbts.2025.05.005

Navid Kashaninejad, Prabuddha De Saram, Mohamed A Abdelfattah, Azeez Bakare, Hoang Huy Vu

{"title":"Wearable biosensors for cancer detection and monitoring.","authors":"Navid Kashaninejad, Prabuddha De Saram, Mohamed A Abdelfattah, Azeez Bakare, Hoang Huy Vu","doi":"10.1016/bs.pmbts.2025.05.005","DOIUrl":"https://doi.org/10.1016/bs.pmbts.2025.05.005","url":null,"abstract":"Wearable biosensors have emerged as game changers in healthcare, particularly for cancer detection and monitoring. Continuously sensing physiological and biochemical markers improves cancer diagnosis and treatment significantly. Conventional diagnostic methods, such as biopsies and imaging, are invasive, expensive, and logistically challenging, limiting their frequency and accessibility. Over the past decade, advances in microfluidics and surface engineering have expanded the capabilities of wearable biosensors. Readily accessible body fluids, such as sweat, saliva, tears, and interstitial fluid (ISF), are now recognized as valuable, non-invasive sources of tumor biomarkers. These fluids provide critical insights into tumor progression and therapy response, offering a patient-friendly alternative to traditional diagnostics. The integration of cutting-edge materials, advanced sensing technologies, and microfluidics has dramatically enhanced the sensitivity and specificity of wearable biosensors. This progress paves the way for personalized and preventive healthcare, improving patient convenience and reducing clinical visits and invasive procedures. This chapter explores the fundamental design principles, practical applications, and existing challenges of wearable biosensors. By addressing these issues, wearable biosensors can play a transformative role in early cancer detection and personalized treatment, ultimately improving patient outcomes.","PeriodicalId":21157,"journal":{"name":"Progress in molecular biology and translational science","volume":"215 ","pages":"311-354"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144668260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Wearable privacy. 可穿戴的隐私。

3区生物学

Progress in molecular biology and translational science Pub Date : 2025-01-01 Epub Date: 2025-07-17 DOI: 10.1016/bs.pmbts.2025.06.005

Vivian Genaro Motti, Huining 'Selina' Feng

{"title":"Wearable privacy.","authors":"Vivian Genaro Motti, Huining 'Selina' Feng","doi":"10.1016/bs.pmbts.2025.06.005","DOIUrl":"https://doi.org/10.1016/bs.pmbts.2025.06.005","url":null,"abstract":"Wearable technology has a promising potential to transform users' lives by continuously collecting data and providing convenient services on demand. Yet, there is also a large potential to breach users' privacy compromising the confidentiality of sensitive data. The lack of privacy regulations is caused by a limited understanding of how to control data collection, access and sharing. Also, the lack of privacy regulations for wearables hinders effective controls for data sharing. This issue is further complicated due to the lack of policies governing the use of wearables in public places, the novelty of such devices and their services, as well as the challenges to identify the threats to data misuse. In this chapter, we examine the landscape of wearable technology focusing on user privacy and data protection. We describe the implications of data disclosure, discussing risks and benefits involved. We provide scenarios where these issues arise and discuss technical solutions including data anonymization and access controls. We review solutions designed to protect users' privacy rights, evaluating their effectiveness and limitations. Lastly, we present solutions created to protect users' privacy. The chapter concludes by outlining a roadmap for future research and development in wearable privacy. We highlight open questions for next-generation devices and provide practical recommendations for end users to safeguard their privacy. Key areas for future research include enhancing user consent mechanisms and improving transparency in data practices. By addressing these gaps, we aim to better protect user privacy in an increasingly interconnected world.","PeriodicalId":21157,"journal":{"name":"Progress in molecular biology and translational science","volume":"216 ","pages":"27-48"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145024171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Daptomycin: Mechanism of action, mechanisms of resistance, synthesis and structure-activity relationships. 达托霉素：作用机制、耐药机制、合成及构效关系。

3区生物学

Progress in molecular biology and translational science Pub Date : 2025-01-01 Epub Date: 2024-04-27 DOI: 10.1016/bs.pmbts.2024.04.003

Scott D Taylor, Ryan Moreira

{"title":"Daptomycin: Mechanism of action, mechanisms of resistance, synthesis and structure-activity relationships.","authors":"Scott D Taylor, Ryan Moreira","doi":"10.1016/bs.pmbts.2024.04.003","DOIUrl":"10.1016/bs.pmbts.2024.04.003","url":null,"abstract":"Daptomycin is a cyclic lipodepsipeptide antibiotic that is a mainstay for the treatment of serious infections caused by Gram-positive bacteria, including methicillin-resistant Streptococcus aureus and vancomycin resistant enterococci. It is one of the so-called last-resort antibiotics that are used to tackle life-threatening infections that do not respond to first-line treatments. However, resistance to daptomycin is eroding its clinical efficacy motivating the design and/or discovery of analogues that overcome resistance. The strategy of antibiotic analogue synthesis has been used to overcome bacterial resistance to many classes of antibiotics such as the β-lactams. Pursuing this strategy with daptomycin requires a detailed understanding of daptomycin's action mechanism and synthesis. Here, we discuss the action mechanism of daptomycin in a holistic manner and expand this discussion to rationalize conferred modes of resistance. Synthetic efforts, both chemical and biological, are discussed in detail and the structure-activity relationship emanating from these works is distilled into a usable model that can guide the design of new daptomycin analogues.","PeriodicalId":21157,"journal":{"name":"Progress in molecular biology and translational science","volume":"212 ","pages":"163-234"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143693143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The ethical and regulatory landscape of wearable, ingestible, and implantable technologies in the United States. 美国可穿戴、可食用和可植入技术的伦理和监管格局。

3区生物学

Progress in molecular biology and translational science Pub Date : 2025-01-01 Epub Date: 2025-07-19 DOI: 10.1016/bs.pmbts.2025.06.004

Ishaan Jain, George S Sellers, Armaan Jain, Astha Agarwal, Raju S Davé

{"title":"The ethical and regulatory landscape of wearable, ingestible, and implantable technologies in the United States.","authors":"Ishaan Jain, George S Sellers, Armaan Jain, Astha Agarwal, Raju S Davé","doi":"10.1016/bs.pmbts.2025.06.004","DOIUrl":"https://doi.org/10.1016/bs.pmbts.2025.06.004","url":null,"abstract":"Biosensing technologies, including wearables, ingestibles, and implantables, are transforming modern healthcare by enabling real-time monitoring and precise personalized treatment. As these technologies advance, ensuring their safety, efficacy, and ethical deployment remains paramount. This chapter explores the regulatory framework that governs biosensing devices in the United States, detailing premarket approval pathways, postmarket surveillance, and emerging regulatory incentives that balance innovation with patient protection. The discussion extends beyond compliance to address critical ethical considerations, including data privacy, informed consent, patient data ownership, and equitable access. By examining case studies of successful and failed biosensing devices, this chapter provides a comprehensive analysis of the evolving landscape, offering guidance for manufacturers, policymakers, and healthcare providers. A proactive approach to regulation and ethics will be essential to ensuring biosensing technologies enhance healthcare outcomes while maintaining public trust.","PeriodicalId":21157,"journal":{"name":"Progress in molecular biology and translational science","volume":"216 ","pages":"49-85"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145024199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Wearable biosensors for autoimmune disorders. 用于自身免疫性疾病的可穿戴生物传感器

3区生物学

Progress in molecular biology and translational science Pub Date : 2025-01-01 Epub Date: 2025-05-19 DOI: 10.1016/bs.pmbts.2025.05.008

Jyot Thesia, Alok Pandya

{"title":"Wearable biosensors for autoimmune disorders.","authors":"Jyot Thesia, Alok Pandya","doi":"10.1016/bs.pmbts.2025.05.008","DOIUrl":"https://doi.org/10.1016/bs.pmbts.2025.05.008","url":null,"abstract":"Millions of people are affected worldwide by autoimmune disorders, including rheumatoid arthritis, lupus, multiple sclerosis and others, whose immune attacks also do not occur in a straightforward or stable manner. Dynamic changes of disease progression and treatment efficacy are not regularly monitored or diagnosed using conventional diagnostic and monitoring techniques. Wearable biosensors (WBS) provide a transformational solution for continuous, minimally invasive biomarker monitoring including cytokines, autoantibodies and acute phase proteins. This paper reviews the pathophysiology underlying WBS in autoimmune disease management, the relevant biomarkers, and the recent advances in biosensor technology. Sensitivity, specificity, stability and biocompatibility issues have also been addressed. Towards the future, our vision includes future prospects in big data analytics and artificial intelligence for predictive modeling, material science advancements for improving sensor performance, noninvasive monitoring technologies, and omics integration for a complete health status of the patient. These innovations have the ability to affect patients suffering from autoimmune disease in a personalized, data driven, and real time manner.","PeriodicalId":21157,"journal":{"name":"Progress in molecular biology and translational science","volume":"215 ","pages":"405-418"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144668259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Artificial intelligence and machine learning heuristics for discovery of ncRNAs. 人工智能和机器学习启发式发现ncrna。

3区生物学

Progress in molecular biology and translational science Pub Date : 2025-01-01 Epub Date: 2025-01-22 DOI: 10.1016/bs.pmbts.2025.01.002

Alfredo Benso, Gianfranco Politano

引用次数: 0

Non-coding RNAs and their integrated biological networks. 非编码rna及其整合的生物网络。

3区生物学

Progress in molecular biology and translational science Pub Date : 2025-01-01 Epub Date: 2025-06-06 DOI: 10.1016/bs.pmbts.2025.05.014

Bilal Ahmed Abbasi, Renuka Suravajhala, V S Sundararajan, Jayaraman Valadi, Prashanth Suravajhala

引用次数: 0

Epigenetic and experimental approaches influencing non-coding RNAs. 影响非编码rna的表观遗传学和实验方法。

3区生物学

Progress in molecular biology and translational science Pub Date : 2025-01-01 Epub Date: 2025-06-06 DOI: 10.1016/bs.pmbts.2025.05.001

Urvashi Vijay, Ashmeet Kaur, Sunil Polipalli

{"title":"Epigenetic and experimental approaches influencing non-coding RNAs.","authors":"Urvashi Vijay, Ashmeet Kaur, Sunil Polipalli","doi":"10.1016/bs.pmbts.2025.05.001","DOIUrl":"10.1016/bs.pmbts.2025.05.001","url":null,"abstract":"Epigenetics having sundry ambiences which are robustly linked to non-coding RNAs, precisely small RNAs that are generally imputated in gene expression regulation and helps in directing cytosine methylation and histone modifications of complex organisms. A pivotal peculiarity of epigenetics is that the same genome shows unwonted phenotypes which are situated in different epigenetics states. In last decade, the majority tangled epigenetic phenomena studied encompasses transposon activity and silencing which are directly or indirectly associated in RNA component and are currently epitomize by piRNAs (piwi-interacting RNAs), position effect variegation, X-chromosome inactivation, parental imprinting, and paramutation. Envisagly, there are certain non - coding RNAs are players in epigenetics gene regulation but their mechanism is still underlying. In yeast, plants, and mice, ncRNAs facilitate the inheritance of epigenetic states, effectively transmitting information across generations. This transgenerational epigenetic inheritance underscores the potential of ncRNAs to act as carriers of heritable information, bridging the gap between environmental cues and genetic responses. In conclusion, ncRNAs play a central role in epigenetic regulation and the transfer of genetic information, highlighting their importance in the evolution and complexity of higher organisms. In this review article, ongoing research continues to uncover the multifaceted functions of these molecules, offering deeper insights into the regulatory architectures that underpin life.","PeriodicalId":21157,"journal":{"name":"Progress in molecular biology and translational science","volume":"214 ","pages":"65-79"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144340381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring the critical role of non-coding RNAs in plant development and stress adaptation-current status and insights. 探索非编码rna在植物发育和逆境适应中的关键作用-现状和见解。

3区生物学

Progress in molecular biology and translational science Pub Date : 2025-01-01 Epub Date: 2025-02-06 DOI: 10.1016/bs.pmbts.2025.01.003

Nilesh Wagh, Pranav Amane, Rahul Kshirsagar, Sayanti Mandal, P B Kavi Kishor, Penna Suprasanna

{"title":"Exploring the critical role of non-coding RNAs in plant development and stress adaptation-current status and insights.","authors":"Nilesh Wagh, Pranav Amane, Rahul Kshirsagar, Sayanti Mandal, P B Kavi Kishor, Penna Suprasanna","doi":"10.1016/bs.pmbts.2025.01.003","DOIUrl":"10.1016/bs.pmbts.2025.01.003","url":null,"abstract":"Non-coding RNAs (ncRNAs), a major fraction of the genome earlier considered as transcriptomic noise has now been uncovered as functional regulators over the past decade. NcRNAs are recognized for their structural and regulatory role in intricate network of plant development and stress response, offering novel insights into molecular mechanisms underlying plant resilience. Advanced sequencing technologies have facilitated the identification and characterization of ncRNAs, highlighting their significance in plant growth, development, and stress responses. This review comprehensively addresses the varied roles of ncRNAs in orchestrating stress perception and response with a brief introduction of various classes of ncRNAs. Further, mode of action and mechanistic role of ncRNAs in modulating genetic regulation of stress response are discussed, along with the role of various ncRNA involved in regulating plant architectural changes. The ncRNA are currently exploited for developing stress-resilient crop varieties with improved yield, especially in the context of global climate change and food security. By integrating molecular perspectives with practical implications, this review offers a thorough understanding of how ncRNAs contribute to plant stress responses, paving the way for innovative strategies in crop improvement and sustainable agriculture.","PeriodicalId":21157,"journal":{"name":"Progress in molecular biology and translational science","volume":"214 ","pages":"19-64"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144340382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0