每一段伟大的旅程都始于第一步:低聚的重要性

3区 生物学 Q2 Biochemistry, Genetics and Molecular Biology
Mansoureh Mirza Agha, Fatemeh Aziziyan, Vladimir N Uversky
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引用次数: 0

摘要

蛋白质低聚物广泛存在于自然界中,具有重要的生理和病理功能。根据其功能和毒性,它们可分为三类。目前,功能性低聚物的开发取得了重大进展,其重点是各种应用及其工程设计。抗菌肽寡聚体在杀死细菌和癌细胞方面发挥作用。最近的研究结果表明,神经退行性疾病的主要致病物质是淀粉样蛋白低聚物,这也是本章的主要内容。它们在整个聚集过程中产生,既是后续聚集途径的中间产物,也是最终产物。它们中的一些可能具有强大的细胞毒性,并通过不同的机制造成细胞损伤,最终导致细胞死亡和疾病进展。由于其本身的不稳定性和结构的多变性,有关其结构、形成机制和毒性的信息十分有限。本章旨在简要概述当前有关淀粉样蛋白寡聚体的知识。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Each big journey starts with a first step: Importance of oligomerization.

Protein oligomers, widely found in nature, have significant physiological and pathological functions. They are classified into three groups based on their function and toxicity. Significant advancements are being achieved in the development of functional oligomers, with a focus on various applications and their engineering. The antimicrobial peptides oligomers play roles in death of bacterial and cancer cells. The predominant pathogenic species in neurodegenerative disorders, as shown by recent results, are amyloid oligomers, which are the main subject of this chapter. They are generated throughout the aggregation process, serving as both intermediates in the subsequent aggregation pathways and ultimate products. Some of them may possess potent cytotoxic properties and through diverse mechanisms cause cellular impairment, and ultimately, the death of cells and disease progression. Information regarding their structure, formation mechanism, and toxicity is limited due to their inherent instability and structural variability. This chapter aims to provide a concise overview of the current knowledge regarding amyloid oligomers.

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来源期刊
CiteScore
6.90
自引率
0.00%
发文量
0
审稿时长
>12 weeks
期刊介绍: Progress in Molecular Biology and Translational Science (PMBTS) provides in-depth reviews on topics of exceptional scientific importance. If today you read an Article or Letter in Nature or a Research Article or Report in Science reporting findings of exceptional importance, you likely will find comprehensive coverage of that research area in a future PMBTS volume.
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