Progress in molecular biology and translational science最新文献_第2页

Surface modified proteins and peptides for targeted drug delivery. 靶向药物递送的表面修饰蛋白和多肽。

3区生物学

Progress in molecular biology and translational science Pub Date : 2025-01-01 Epub Date: 2025-01-27 DOI: 10.1016/bs.pmbts.2024.12.001

Vivek P Chavda, Disha Joshi

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Peptide pharmacology: Pioneering interventions for alcohol use disorder. 肽药理学：酒精使用障碍的开创性干预措施。

3区生物学

Progress in molecular biology and translational science Pub Date : 2025-01-01 Epub Date: 2024-06-28 DOI: 10.1016/bs.pmbts.2024.05.003

Ramkumar Katturajan, Sabina Evan Prince, Abilash Valsala Gopalakrishnan

{"title":"Peptide pharmacology: Pioneering interventions for alcohol use disorder.","authors":"Ramkumar Katturajan, Sabina Evan Prince, Abilash Valsala Gopalakrishnan","doi":"10.1016/bs.pmbts.2024.05.003","DOIUrl":"10.1016/bs.pmbts.2024.05.003","url":null,"abstract":"Alcohol use disorder (AUD) is a substantial public health issue, with few treatment choices and a high social cost. This review investigates the possibility of peptide pharmacology as a new treatment for AUD. Peptides, or short chains of amino acids, provide specific manipulation of neuronal pathways involved in addiction, such as the opioid, corticotropin-releasing factor (CRF), neuropeptide Y (NPY), and glutamate systems. Preclinical research has shown that peptide-based therapies can reduce alcohol intake, demand, and relapse in animal models of AUD. Opioid peptides like β-endorphin and enkephalins affect alcohol reward processing by interacting with µ, ∂, and κ opioid receptors. CRF peptides reduce stress-induced alcohol-seeking behavior by targeting the dysregulated CRF system. NPY and associated peptides reduce cravings and anxiety by regulating stress and emotional processing. Peptide-based therapies have strong translational potential, as evidenced by early clinical trial results. There are also challenges in converting preclinical discoveries into clinical practice, such as establishing the safety, tolerability, and effectiveness of peptide therapies in humans. Future initiatives include identifying new peptide targets, optimizing pharmacokinetics, and incorporating peptide-based therapies into established therapy methods. Overall, peptide pharmacology represents a potential prospect in AUD therapy, as it provides tailored therapies that address the complex neurobiological pathways that underpin addiction.","PeriodicalId":21157,"journal":{"name":"Progress in molecular biology and translational science","volume":"212 ","pages":"117-128"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143693153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Delivery of therapeutic proteins to ocular tissues: Barriers, approaches, regulatory considerations and future perspectives. 治疗性蛋白向眼组织的输送：障碍、途径、调控考虑和未来展望。

3区生物学

Progress in molecular biology and translational science Pub Date : 2025-01-01 Epub Date: 2024-09-12 DOI: 10.1016/bs.pmbts.2024.08.003

Divyesh Harshadkumar Shastri

{"title":"Delivery of therapeutic proteins to ocular tissues: Barriers, approaches, regulatory considerations and future perspectives.","authors":"Divyesh Harshadkumar Shastri","doi":"10.1016/bs.pmbts.2024.08.003","DOIUrl":"10.1016/bs.pmbts.2024.08.003","url":null,"abstract":"The administration of therapeutic proteins directly to the eye is a major breakthrough in the treatment of several eye conditions. This chapter highlights the crucial significance of ocular therapies because of the widespread occurrence of vision-threatening disorders and the distinct difficulties presented by the eye's architecture and physiological limitations. Therapeutic proteins, known for their exceptional specificity and effectiveness, provide hopeful answers. However, they encounter various obstacles in their ocular distributions like tear film, corneal epithelium, and blood-retinal barrier etc. Formulation techniques and drug delivery technologies, such as nanotechnology, hydrogels, microneedles, liposomes, dendrimers, and polymeric nanoparticles are improving the stability, bioavailability, and targeted administration of proteins. Notwithstanding this progress, obstacles such as protein stability, immunogenicity, and patient compliance endure. Methods to address these challenges include improving permeability, formulating sustained release systems, applying non-invasive delivery techniques, and implementing tailored delivery strategies. Furthermore, it is essential to effectively navigate through regulatory routes, comprehensively grasp market factors, and successfully secure intellectual property to achieve successful commercialization of these new methods.","PeriodicalId":21157,"journal":{"name":"Progress in molecular biology and translational science","volume":"212 ","pages":"261-277"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143693147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Copyright 版权

3区生物学

Progress in molecular biology and translational science Pub Date : 2024-01-16 DOI: 10.1016/s1877-1173(24)00010-3

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Index 索引

3区生物学

Progress in molecular biology and translational science Pub Date : 2024-01-16 DOI: 10.1016/s1877-1173(24)00014-0

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Half Title Page 半扉页

3区生物学

Progress in molecular biology and translational science Pub Date : 2024-01-16 DOI: 10.1016/s1877-1173(24)00008-5

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Contributors 贡献者

3区生物学

Progress in molecular biology and translational science Pub Date : 2024-01-16 DOI: 10.1016/s1877-1173(24)00011-5

引用次数: 0

Title Page 标题页

3区生物学

Progress in molecular biology and translational science Pub Date : 2024-01-16 DOI: 10.1016/s1877-1173(24)00009-7

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SARS-CoV-2 variant biology and immune evasion SARS-CoV-2 变异生物学和免疫逃避

3区生物学

Progress in molecular biology and translational science Pub Date : 2024-01-04 DOI: 10.1016/bs.pmbts.2023.11.007

Asiya Kamber Zaidi, Rohan Bir Singh

{"title":"SARS-CoV-2 variant biology and immune evasion","authors":"Asiya Kamber Zaidi, Rohan Bir Singh","doi":"10.1016/bs.pmbts.2023.11.007","DOIUrl":"https://doi.org/10.1016/bs.pmbts.2023.11.007","url":null,"abstract":"This chapter discusses the SARS-CoV-2 variants and their immune evasion strategies, shedding light on the dynamic nature of the COVID-19 pandemic. The ecological dynamics and viral evolution of SARS-CoV-2 are explored, considering carriers of infection, individual immunity profiles, and human movement as key factors in the emergence and dissemination of variants. The chapter discusses SARS-CoV-2 mutation, including mutation rate, substitution rate, and recombination, influencing genetic diversity and evolution.Transmission bottlenecks are highlighted as determinants of dominant variants during viral spread. The evolution phases of the pandemic are outlined, from limited early evolution to the emergence of notable changes like the D614G substitution and variants with heavy mutations. Variants of Concern (VOCs), including Alpha, Beta, Gamma, and the recent Omicron variant, are examined, with insights into inter-lineage and intra-lineage dynamics. The origin of VOCs and the Omicron variant is explored, alongside the role of the furin cleavage site (FCS) in variant emergence. The impact of structural and non-structural proteins on viral infectivity is assessed, as well as innate immunity evasion strategies employed by SARS-CoV-2 variants. The chapter concludes by considering future possibilities, including ongoing virus evolution, the need for surveillance, vaccine development, and public health measures.","PeriodicalId":21157,"journal":{"name":"Progress in molecular biology and translational science","volume":"95 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139474774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Epidemiology of COVID-19 COVID-19 的流行病学

3区生物学

Progress in molecular biology and translational science Pub Date : 2024-01-04 DOI: 10.1016/bs.pmbts.2023.09.002

Asiya Kamber Zaidi, Rohan Bir Singh

引用次数: 0