Progress in molecular biology and translational science最新文献_第2页

Ingestible biosensors for monitoring digestive health and nutritional monitoring. 用于监测消化健康和营养监测的可消化生物传感器。

3区生物学

Progress in molecular biology and translational science Pub Date : 2025-01-01 Epub Date: 2025-07-16 DOI: 10.1016/bs.pmbts.2025.06.007

Malvika Shukla, Alok Pandya

引用次数: 0

Delivery of protein therapeutics and vaccines using their multivalent complexes with synthetic polyelectrolytes. 利用蛋白质治疗剂和疫苗的多价复合物与合成聚电解质的递送。

3区生物学

Progress in molecular biology and translational science Pub Date : 2025-01-01 Epub Date: 2024-05-03 DOI: 10.1016/bs.pmbts.2024.04.005

Alexander K Andrianov

{"title":"Delivery of protein therapeutics and vaccines using their multivalent complexes with synthetic polyelectrolytes.","authors":"Alexander K Andrianov","doi":"10.1016/bs.pmbts.2024.04.005","DOIUrl":"10.1016/bs.pmbts.2024.04.005","url":null,"abstract":"Clinical applications of protein and peptide-based therapeutics and vaccines are rapidly expanding. However, the development of promising new product candidates is often hindered by unfavorable pharmacokinetic profiles, which necessitate the implementation of drug delivery systems to improve protein stability and bioavailability. Non-covalent modification of proteins with synthetic polyelectrolytes, which relies on the strength of cooperative multivalent interactions, may offer potential advantages. In contrast to commonly employed covalent conjugation or microencapsulation methodologies, this technology offers dynamic protection of the protein thereby minimizing the loss of its biological activity, enabling \"mix-and-match\" formulation approaches, reducing manufacturing costs and simplifying regulatory processes. The range of potential life sciences applications ranges from immunopotentiation and vaccine delivery systems to long-circulating stealth biotherapeutics. This review analyses current technology in the context of intended clinical indications and discusses various synthetic and formulation approaches leading to supramolecular complexation. It evaluates dynamic interactions of complexes with constituents of physiological compartments and attempts to identify critical factors that can affect future advancement of this paradigm-shifting protein delivery technology.","PeriodicalId":21157,"journal":{"name":"Progress in molecular biology and translational science","volume":"212 ","pages":"235-259"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143693145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advanced energy storage systems as power sources for biosensing technologies. 作为生物传感技术动力源的先进储能系统。

3区生物学

Progress in molecular biology and translational science Pub Date : 2025-01-01 Epub Date: 2025-05-31 DOI: 10.1016/bs.pmbts.2025.05.012

Clara R Pereira, André M Pereira, Joana S Teixeira, Ana R Sousa, Gabriela P Queirós, Rui S Costa, Marta S Nunes, Mariana Rocha

引用次数: 0

Biofluid-based biosensors: Analyzing biomarkers for disease detection. 基于生物流体的生物传感器：分析疾病检测的生物标志物。

3区生物学

Progress in molecular biology and translational science Pub Date : 2025-01-01 Epub Date: 2025-05-03 DOI: 10.1016/bs.pmbts.2025.04.001

Hossein Chenani, Mohsen Saeidi, Abdolreza Simchi

{"title":"Biofluid-based biosensors: Analyzing biomarkers for disease detection.","authors":"Hossein Chenani, Mohsen Saeidi, Abdolreza Simchi","doi":"10.1016/bs.pmbts.2025.04.001","DOIUrl":"https://doi.org/10.1016/bs.pmbts.2025.04.001","url":null,"abstract":"The advancement of biofluid-based biosensors (BBs) generates significant interest owing to their capacity for non-invasive, real-time health assessment. These biosensors, proficient in assessing biomarkers in body fluids like sweat, saliva, interstitial fluid, tears, blood, and urine, provide significant benefits in illness detection and individualized healthcare. Recent breakthroughs in sensor technology, encompassing the incorporation of nanomaterials, microfluidics, and wearable electronics, have markedly enhanced the sensitivity, specificity, and portability of biosensors. This chapter examines different types of biosensors, elucidating their functions and applications in the monitoring of various diseases, including metabolic disorders, infectious diseases, and cancer. It also tackles critical issues in the development and implementation of BBs, including attaining long-term stability, standardizing sampling techniques, and confirming their clinical diagnostic efficacy. Current trends are examined, especially the use of artificial intelligence and data analytics for biosensor data interpretation. Finally, the chapter provides some thoughts on the possible integration of these technologies into telemedicine and wearable health devices and their prospects for the future of digital healthcare.","PeriodicalId":21157,"journal":{"name":"Progress in molecular biology and translational science","volume":"215 ","pages":"63-99"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144668253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preface. 前言。

3区生物学

Progress in molecular biology and translational science Pub Date : 2025-01-01 DOI: 10.1016/S1877-1173(25)00119-X

引用次数: 0

Membrane-active peptides for anticancer therapies. 用于抗癌治疗的膜活性肽。

3区生物学

Progress in molecular biology and translational science Pub Date : 2025-01-01 Epub Date: 2024-11-01 DOI: 10.1016/bs.pmbts.2024.10.005

Charles H Chen

{"title":"Membrane-active peptides for anticancer therapies.","authors":"Charles H Chen","doi":"10.1016/bs.pmbts.2024.10.005","DOIUrl":"10.1016/bs.pmbts.2024.10.005","url":null,"abstract":"Membrane-active peptides are found in many living organisms and play a critical role in their immune systems by combating various infectious diseases. These host defense peptides employ multiple mechanisms against different microorganisms and possess unique functions, such as anti-inflammatory and immunomodulatory effects, often working in synergy with other antimicrobial agents. Despite extensive research over the past few decades and the identification of thousands of sequences, only a few have been successfully applied in clinical settings and received approval from the U.S. Food and Drug Administration. In this chapter, we explore all peptide therapeutics that have reached the market, as well as candidates in preclinical and clinical trials, to understand their success and potential applications in cancer therapy. Our findings indicate that at least four membrane-active peptide drugs have progressed to preclinical or clinical phases, dmonstrating promising results for cancer treatment. We summarize our insights in this chapter, highlighting the potential of membrane-active anticancer peptide therapeutics and their applications as targeting ligands in various biomedical fields.","PeriodicalId":21157,"journal":{"name":"Progress in molecular biology and translational science","volume":"212 ","pages":"67-116"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143693149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Peptides on patrol: Carrier systems for targeted delivery. 巡逻中的多肽：靶向递送的载体系统。

3区生物学

Progress in molecular biology and translational science Pub Date : 2025-01-01 Epub Date: 2025-01-30 DOI: 10.1016/bs.pmbts.2024.11.001

Vivek P Chavda, Joanna Bojarska

引用次数: 0

Peptidomimetics design and characterization: Bridging experimental and computer-based approaches. 拟态肽设计与表征：连接实验与计算机方法。

3区生物学

Progress in molecular biology and translational science Pub Date : 2025-01-01 Epub Date: 2024-07-25 DOI: 10.1016/bs.pmbts.2024.07.002

Alice Romagnoli, Jesmina Rexha, Nunzio Perta, Samuele Di Cristofano, Noemi Borgognoni, Gloria Venturini, Francesco Pignotti, Domenico Raimondo, Tiziana Borsello, Daniele Di Marino

{"title":"Peptidomimetics design and characterization: Bridging experimental and computer-based approaches.","authors":"Alice Romagnoli, Jesmina Rexha, Nunzio Perta, Samuele Di Cristofano, Noemi Borgognoni, Gloria Venturini, Francesco Pignotti, Domenico Raimondo, Tiziana Borsello, Daniele Di Marino","doi":"10.1016/bs.pmbts.2024.07.002","DOIUrl":"10.1016/bs.pmbts.2024.07.002","url":null,"abstract":"Peptidomimetics, designed to mimic peptide biological activity with more drug-like properties, are increasingly pivotal in medicinal chemistry. They offer enhanced systemic delivery, cell penetration, target specificity, and protection against peptidases when compared to their native peptide counterparts. Already utilized in treating diverse diseases like neurodegenerative disorders, cancer and infectious diseases, their future in medicine seems bright, with many peptidomimetics in clinical trials or development stages. Peptidomimetics are well-suited for addressing disturbed protein-protein interactions (PPIs), which often underlie various pathologies. Structural biology and computational methods like molecular dynamics simulations facilitate rational design, whereas machine learning algorithms accelerate protein structure prediction, enabling efficient drug development. Experimental validation via various spectroscopic, biophysical, and biochemical assays confirms computational predictions and guides further optimization. Peptidomimetics, with their tailored constrained structures, represent a frontier in drug design focused on targeting PPIs. In this overview, we present a comprehensive landscape of peptidomimetics, encompassing perspectives on involvement in pathologies, chemical strategies, and methodologies for their characterization, spanning in silico, in vitro and in cell approaches. With increasing interest from pharmaceutical sectors, peptidomimetics hold promise for revolutionizing therapeutic approaches, marking a new era of precision drug discovery.","PeriodicalId":21157,"journal":{"name":"Progress in molecular biology and translational science","volume":"212 ","pages":"279-327"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143693174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tools and databases for non-coding RNAs. 非编码rna的工具和数据库。

3区生物学

Progress in molecular biology and translational science Pub Date : 2025-01-01 Epub Date: 2025-05-31 DOI: 10.1016/bs.pmbts.2025.05.003

Akshaykumar Zawar, Srinka Datta, Rishita Rathi, Rituja Shinde, Anushka Kalamkar, Neeraj Dangi, Poonam Deshpande

{"title":"Tools and databases for non-coding RNAs.","authors":"Akshaykumar Zawar, Srinka Datta, Rishita Rathi, Rituja Shinde, Anushka Kalamkar, Neeraj Dangi, Poonam Deshpande","doi":"10.1016/bs.pmbts.2025.05.003","DOIUrl":"10.1016/bs.pmbts.2025.05.003","url":null,"abstract":"Non-coding RNAs (ncRNAs) play a crucial role in various cellular processes, challenging the earlier notion that non-coding regions of the genome are merely \"junk DNA.\" Advances in molecular biology and sequencing technologies have revealed that these regions contain essential genetic elements, including ncRNAs, which influence gene regulation and other biological functions. As the significance of ncRNAs in human health and disease becomes increasingly clear, researchers have developed methods to identify, annotate, and classify these molecules into distinct types. Additionally, a growing interest has emerged in studying genetic variations within ncRNA genes and their potential implications in disease development. Understanding these variations can provide insights into how ncRNAs contribute to gene regulation and cellular function. This article explores the current landscape of ncRNA research, highlighting the latest techniques for detecting and identifying different classes of ncRNAs. Furthermore, it discusses computational tools and databases available for annotating ncRNAs and analyzing their functions across various biological processes. By integrating experimental and computational approaches, researchers can gain a deeper understanding of ncRNA roles, paving the way for potential therapeutic applications.","PeriodicalId":21157,"journal":{"name":"Progress in molecular biology and translational science","volume":"214 ","pages":"163-178"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144340310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advancements in wearable biosensors: Transforming cardiovascular health monitoring and disease management. 可穿戴生物传感器的进展：改变心血管健康监测和疾病管理。

3区生物学

Progress in molecular biology and translational science Pub Date : 2025-01-01 Epub Date: 2025-05-20 DOI: 10.1016/bs.pmbts.2025.05.006

Perla Boutros, Nour Kassem, Sandra Barteit

引用次数: 0