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In silico approach of bioactive molecule chitosan 501.1 kDa from snail shell as antioxidant and inhibitor of the keap1-nrf2 protein-protein interaction 壳聚糖501.1 kDa生物活性分子作为keap1-nrf2蛋白相互作用的抗氧化剂和抑制剂的硅法研究
Pharmacy Education Pub Date : 2023-10-10 DOI: 10.46542/pe.2023.234.510
Umarudin Umarudin, Sri Widyarti, Warsito Warsito, Sri Rahayu
{"title":"In silico approach of bioactive molecule chitosan 501.1 kDa from snail shell as antioxidant and inhibitor of the keap1-nrf2 protein-protein interaction","authors":"Umarudin Umarudin, Sri Widyarti, Warsito Warsito, Sri Rahayu","doi":"10.46542/pe.2023.234.510","DOIUrl":"https://doi.org/10.46542/pe.2023.234.510","url":null,"abstract":"Background: ROS are created when high levels of oxidative stress occur due to hypercholesterolemia. Nuclear Factor Erythroid 2-related factor (NRF2) controls the expression of antioxidant genes. Kelch-like ECH-associated protein 1 (KEAP1) therapy degrades NRF2. Chitosan 501.1 kDa from snail shells contains bioactive chemicals that can induce NRF2 activity. Objective: To evaluate the potential antioxidant activity of the bioactive compound in Mw 501.1 kDa chitosan by targeting KEAP1 and NRF2 proteins in-silico. Method: The 3D structures of the bioactive compounds chitosan and control 51M were derived from the PubChem database, and the proteins were derived from the RCSB PDB. The biological activity of chitosan bioactive compounds was predicted using the PASS Online server. Molecular docking was performed using Hex 8.0.0 Cuda with Shape+Electro+DARS and visualised with Discovery Studio. The biological activity of chitosan compounds was predicted as lipotropic and antioxidant. Result: The discovery of the bioactive compound chitosan 501.1 kDa interacted strongly with KEAP1. The bioactive compound chitosan also inhibited KEAP1 through residues GLN75 and LEU84 at the 51M-KEAP1 interaction. Conclusion: The bioactive compound chitosan 501.1 kDa could inhibit the interaction of KEAP1-NRF2 proteins so that NRF2 could transcribe antioxidant genes. Therefore, may serve as a suitable alternative.","PeriodicalId":19944,"journal":{"name":"Pharmacy Education","volume":"28 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136353235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Drug safety awareness and rational use of medicines among university students in greater Bandung: A cross-sectional survey 大万隆地区大学生药品安全意识与合理用药:一项横断面调查
Pharmacy Education Pub Date : 2023-10-10 DOI: 10.46542/pe.2023.234.120126
Cindra Tri Yuniar, M. Fawaz El Fauzy, Ardika Fajrul Ihsan, Lia Amalia
{"title":"Drug safety awareness and rational use of medicines among university students in greater Bandung: A cross-sectional survey","authors":"Cindra Tri Yuniar, M. Fawaz El Fauzy, Ardika Fajrul Ihsan, Lia Amalia","doi":"10.46542/pe.2023.234.120126","DOIUrl":"https://doi.org/10.46542/pe.2023.234.120126","url":null,"abstract":"Background: In Indonesia, compliance to the rational use of medicines (RUM) was 47.08% in community healthcare centers, and so might the university students. Objectives: The study aims to evaluate students' knowledge and attitude toward the RUM and identify the correlation between these parameters and drug safety awareness. Method: A cross-sectional study used the online questionnaire among university students in Greater Bandung Area from March-April 2022. Spearman’s rank was carried out in correlation analysis between the parameters. Result: In 342 subjects, 54.1% of students have moderate knowledge of RUM and drug safety awareness (56.7%). However, 80.1% of students have a high attitude towards RUM. Attitude toward RUM formed a significant, weak, and unidirectional correlation with knowledge (r = 0.292) and so did with safety awareness (r = 0.345). Conclusion: Students have a positive attitude towards RUM while having moderate knowledge of RUM and drug safety awareness.","PeriodicalId":19944,"journal":{"name":"Pharmacy Education","volume":"2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136295399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The KLiP Mobile: A model of community engagement programme KLiP流动:社区参与计划的典范
Pharmacy Education Pub Date : 2023-10-10 DOI: 10.46542/pe.2023.234.116119
Maimunah Abdul Muna’aim, Azlina Mokhtar, Muhammad Najmi Khairudin, Hafiz Jaafa, Amirah Azzeri, Tengku Amatullah Madeehah Tengku Mohd
{"title":"The KLiP Mobile: A model of community engagement programme","authors":"Maimunah Abdul Muna’aim, Azlina Mokhtar, Muhammad Najmi Khairudin, Hafiz Jaafa, Amirah Azzeri, Tengku Amatullah Madeehah Tengku Mohd","doi":"10.46542/pe.2023.234.116119","DOIUrl":"https://doi.org/10.46542/pe.2023.234.116119","url":null,"abstract":"Background: KLiP Mobile (Klinik pakar bergerak) is a mobile eye specialist clinic initiated by the state government of Negeri Sembilan and Universiti Sains Islam Malaysia (USIM). It is funded by the state of Negeri Sembilan and managed by USIM. Objectives: The four objectives of this programme are: 1) Providing essential eye services, 2) Enhancing public-private partnerships to support the programme, especially among the underprivileged community for cataract surgery, rehabilitation of vision, and glasses for children and elderly 3) Promoting awareness through knowledge transfer programme on eye disease 4) conducting research. This paper aims to describe the prevalence of common eye diseases among our target population in Negeri Sembilan. Method: This is a cross-sectional study consisting of referred or walk-in patients who visited the KLiP Mobile program between January 2016 to June 2022. Results: The result showed the prevalence of common eye diseases among the population and is comparable with our national eye survey. Conclusion: The KLiP Mobile is a model of community engagement programme and is expected to continue benefiting the community especially those who are unable to access specialist services.","PeriodicalId":19944,"journal":{"name":"Pharmacy Education","volume":"36 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136295401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Risk prediction models on adverse drug reactions: A review 药物不良反应风险预测模型综述
Pharmacy Education Pub Date : 2023-10-10 DOI: 10.46542/pe.2023.234.1115
Fivy Kurniawati, Erna Kristin, Sri Awalia Febriana, Rizaldy T. Pinzon
{"title":"Risk prediction models on adverse drug reactions: A review","authors":"Fivy Kurniawati, Erna Kristin, Sri Awalia Febriana, Rizaldy T. Pinzon","doi":"10.46542/pe.2023.234.1115","DOIUrl":"https://doi.org/10.46542/pe.2023.234.1115","url":null,"abstract":"Background: The risk prediction model has become increasingly popular in recent years in helping clinical decision-making. Existing models cannot be directly applied in Indonesia. Objective: To review the existing prediction models and their limitations. Method: A search related to the prediction of ADR risk was conducted using several journal databases: PubMed, Scopus and Google Scholar. Articles were screened to match specified criteria and further studied. Result: Nine articles met the criteria and were then analysed. Studies were carried out in various countries. The study population include; the elderly (>65 years, three studies), age (≥15 years, three studies), patients with Chronic Kidney Disease (CKD) (≥18 years, one study) and two studies in cancer patients. The outcomes were; ADR (five studies), ADE ( two studies), DRPs (one study), and cardiovascular effects (one study). The methods for determining the predictors of ADRs all used multivariable logistic regression. Conclusion: Each country has different treatment patterns, prescribing practices, traditions and drug distribution, so it is necessary to develop a prediction model for ADRs that is country-specific.","PeriodicalId":19944,"journal":{"name":"Pharmacy Education","volume":"70 6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136352757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Patient’s perception of the image of community pharmacists 患者对社区药师形象的感知
Pharmacy Education Pub Date : 2023-10-10 DOI: 10.46542/pe.2023.234.6670
Hasan Ismail, Umi Athijah, Widi Hidayat, Abdul Rahem
{"title":"Patient’s perception of the image of community pharmacists","authors":"Hasan Ismail, Umi Athijah, Widi Hidayat, Abdul Rahem","doi":"10.46542/pe.2023.234.6670","DOIUrl":"https://doi.org/10.46542/pe.2023.234.6670","url":null,"abstract":"Background: Patients' understanding of the pharmacists’ role is needed to create a positive image so that it is easier for pharmacists to make patients understand the use of drugs. Objective: This study aimed to assess the public perception of the image of pharmacists in providing services to patients. Method: An observational study was conducted on fifty-three (53) respondents who received pharmaceutical services directly from pharmacists at the pharmacies in East Java. The research variable was the pharmacists' image which is measured through competence, ethics, communication skills, and emotional intelligence based on the perception of the patient. Result: The majority of pharmacists had good ratings for their competence and ethics (96%), and most of the pharmacists were perceived to have good communication skills and emotional intelligence (92% and 79% respectively). Conclusion: The pharmacists' images, according to the patients' perception were in the “good” category, although there is a need to be an increase in emotional intelligence.","PeriodicalId":19944,"journal":{"name":"Pharmacy Education","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136352880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Drug cost analysis of outpatients with cardiovascular disease under the national health insurance scheme 国民健康保险制度下心血管病患者门诊用药费用分析
Pharmacy Education Pub Date : 2023-10-10 DOI: 10.46542/pe.2023.234.14
Andi Bulqiah Nur, Budi Suprapti, Yulistiani Yulistiani, M. Yusuf, Nelly Kurniawati
{"title":"Drug cost analysis of outpatients with cardiovascular disease under the national health insurance scheme","authors":"Andi Bulqiah Nur, Budi Suprapti, Yulistiani Yulistiani, M. Yusuf, Nelly Kurniawati","doi":"10.46542/pe.2023.234.14","DOIUrl":"https://doi.org/10.46542/pe.2023.234.14","url":null,"abstract":"Background: Cardiovascular disease is one of the catastrophic diseases that absorbs the most health budgets. Reimbursement of healthcare costs from the National Health Insurance Agency is done through the case-based groups (INA-CBGs) and fee-for-service (non-INA-CBGs) methods based on e-catalogue drug prices. Drug costs are a concern. Objective: To evaluate drug prescription compliance to the national formulary, total drug cost and drugs cost included in the INA-CBGs package. Method: This observational study used retrospective prescription data from the outpatient Cardiology Clinic. A quantitative analysis was conducted for prescription compliance with formulary and drug costs. Result: Out of the 4,443 prescriptions, the prescription alignment with the national formulary was 98%. The difference between the total e-catalogue and the actual drug costs was IDR4,818,252 (0.9%) (p > 0.05). Drug costs constitute 19% of the INA-CBGs package. Conclusion: Drug prescribing is quite efficient with 98% compliance with the formulary and drug costs constitute 19% of the INA-CBGs package.","PeriodicalId":19944,"journal":{"name":"Pharmacy Education","volume":"69 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136352902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Activities of ethanol-extract of red ginger (Zingiber officinale var. Rubrum) on Completed Freund's Adjuvant-induced arthritis in mice 红姜(Zingiber officinale var. Rubrum)乙醇提取物对完全性弗氏佐剂诱导小鼠关节炎的活性研究
Pharmacy Education Pub Date : 2023-10-10 DOI: 10.46542/pe.2023.234.242246
Fifteen Aprila Fajrin, Putri Robiatul Khasanah, Yokta Esa Mikailla, Diana Holidah, Ika Puspita Dewi
{"title":"Activities of ethanol-extract of red ginger (Zingiber officinale var. Rubrum) on Completed Freund's Adjuvant-induced arthritis in mice","authors":"Fifteen Aprila Fajrin, Putri Robiatul Khasanah, Yokta Esa Mikailla, Diana Holidah, Ika Puspita Dewi","doi":"10.46542/pe.2023.234.242246","DOIUrl":"https://doi.org/10.46542/pe.2023.234.242246","url":null,"abstract":"Background: Red ginger has been known to have anti-inflammatory and analgesic potency. Objective: This study aimed to analyse the ethanolic extract of red ginger (EERG) in mice's arthritis model induced by Completed Freund’s Adjuvant (CFA). Method: Red ginger was extracted using ethanol 96%. Arthritis mice (n = 25) were injected with CFA i.p., and sham mice (n = 5) were injected with normal saline. On day seven, mice were divided into six groups: sham, CFA, gabapentin 100 mg/kg BW, and EERG (dose 200; 400; 600 mg/kg BW). Treatments were administered orally once a day for seven days. Latency time and plantar thickness were measured on days zero, one, three, five, seven, eight, ten, twelve, and fourteen. On day 15, the mice were sacrificed, and the blood and spinal cords were collected. The haematology profiles were determined. Result: The EERG significantly prolonged the latency time towards thermal stimulus and decreased plantar thickness in arthritis mice, the same as gabapentin which served as the control. The EERG also reduced the number of leukocytes, lymphocytes, and neutrophils, and improved the morphology of the spinal cord's dorsal horn of arthritis mice. Conclusion: The EERG of 400 mg/kg BW significantly affects arthritis-induced hyperalgesia.","PeriodicalId":19944,"journal":{"name":"Pharmacy Education","volume":"249 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136353366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An assessment of platelet response to ticagrelor in post-percutaneous coronary intervention patients using light transmission platelet aggregometry (LTA) 应用光透射血小板聚集法(LTA)评价经皮冠状动脉介入术后患者对替格瑞洛的血小板反应
Pharmacy Education Pub Date : 2023-10-10 DOI: 10.46542/pe.2023.234.180184
Bambang Subakti Zulkarnain, Karima Samlan, Junaidi Khotib, Muhammad Yogiarto, Muhammad Aminuddin, Umi Fatmawati
{"title":"An assessment of platelet response to ticagrelor in post-percutaneous coronary intervention patients using light transmission platelet aggregometry (LTA)","authors":"Bambang Subakti Zulkarnain, Karima Samlan, Junaidi Khotib, Muhammad Yogiarto, Muhammad Aminuddin, Umi Fatmawati","doi":"10.46542/pe.2023.234.180184","DOIUrl":"https://doi.org/10.46542/pe.2023.234.180184","url":null,"abstract":"Background: Low on-treatment platelet reactivity (LTPR) or High on-treatment platelet reactivity (HTPR) with P2Y12 inhibitors is associated with bleeding (LTPR) or ischemic events (HTPR) in patients on dual antiplatelet therapy (DAPT) after percutaneous coronary intervention (PCI). Objective: Mapping of Indonesian patients’ platelet response secondary to ticagrelor and thus identifying either LTPR or HTPR. Method: During May – June 2019, 20 post-PCI patients on aspirin–ticagrelor combination were included. Light transmission aggregometry (LTA) for monitoring platelet function was used. Ticagrelor’s LTA <40% is LTPR while >70% is HTPR. Result: Patients were mostly male (18 patients) and aged between 40-73 years old with a history of diabetes and/or hypertension and smoking. About eight patients (40%) were LTPR and one (5%) patient was HTPR. Conclusion: A personalised DAPT strategy for preventing bleeding events, a de-escalation, might be valuable for Indonesian patients.","PeriodicalId":19944,"journal":{"name":"Pharmacy Education","volume":"15 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136353369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Knowledge, attitudes, and practices for using and disposing of antibiotics: A cross-sectional study at an Indonesian community 使用和处置抗生素的知识、态度和做法:印度尼西亚一个社区的横断面研究
Pharmacy Education Pub Date : 2023-10-10 DOI: 10.46542/pe.2023.234.110115
Elida Zairina, Athaya B Azzahrya, Gesnita Nugraheni, Arie Sulistyarini
{"title":"Knowledge, attitudes, and practices for using and disposing of antibiotics: A cross-sectional study at an Indonesian community","authors":"Elida Zairina, Athaya B Azzahrya, Gesnita Nugraheni, Arie Sulistyarini","doi":"10.46542/pe.2023.234.110115","DOIUrl":"https://doi.org/10.46542/pe.2023.234.110115","url":null,"abstract":"Background: Antibiotic misuse and improper disposal contribute to the rise in antibiotic resistance. Objective: This study aimed to assess the knowledge, attitude, and practice of antibiotic use and disposal in Surabaya communities. Method: An electronic questionnaire was circulated through social media using convenience sampling. The data was then analysed descriptively, and any correlation between variables was analysed using SPSS. Result: The research showed that most of the respondents had good knowledge (71.6%), a positive attitude (68.2%), and good practice (78%). The correlation test showed a strong positive correlation between knowledge and practice (r = 0.568; p < 0.05). Conclusion: Most respondents demonstrated good knowledge, attitude, and practice. Nonetheless, education on rational antibiotic use and proper disposal should be significantly expanded.","PeriodicalId":19944,"journal":{"name":"Pharmacy Education","volume":"21 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136294328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Carbomer and ethyl cellulose optimisation in the preparation of mucoadhesive microspheres ciprofloxacin hydrochloride 卡波姆和乙基纤维素在制备盐酸环丙沙星黏附微球中的优化
Pharmacy Education Pub Date : 2023-10-10 DOI: 10.46542/pe.2023.234.2731
Lusia Oktora Ruma Kumala Sari, Lintang Qonita Fardliana, Dwi Nurahmanto, Eka Deddy Irawan
{"title":"Carbomer and ethyl cellulose optimisation in the preparation of mucoadhesive microspheres ciprofloxacin hydrochloride","authors":"Lusia Oktora Ruma Kumala Sari, Lintang Qonita Fardliana, Dwi Nurahmanto, Eka Deddy Irawan","doi":"10.46542/pe.2023.234.2731","DOIUrl":"https://doi.org/10.46542/pe.2023.234.2731","url":null,"abstract":"Background: Ciprofloxacin hydrochloride (CH) is an antibiotic used to treat urinary tract infections. CH has a short half-life and low bioavailability. Microspheres combined with a mucoadhesive system can increase the residence time of the drug in the stomach to increase the bioavailability of CH. Objective: This research was conducted to obtain the best amount of carbomer as a polymer mucoadhesive and ethyl cellulose as a matrix polymer based on factorial design. Method: The factorial design 22 was used to determine the amount of carbomer and ethyl cellulose to produce optimum mucoadhesive microspheres. Three responses were observed in this study: particle size, entrapment efficiency, and mucoadhesive strength. Result: The resulting entrapment efficiency was 69.0%, particle size was 404.52 nm, and mucoadhesive strength was 64.3 grams, with drug loading and yield values of 19.13% and 99.8%, respectively. Conclusion: The optimum formula with the highest response value is the formula containing 300 mg carbomer and 1000 mg ethyl cellulose.","PeriodicalId":19944,"journal":{"name":"Pharmacy Education","volume":"147 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136295565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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