Pharmacy Education最新文献_第5页

The impact of mHealth application on improving medication adherence and hypertension management: A systematic review of randomised trials 移动健康应用对改善药物依从性和高血压管理的影响:随机试验的系统回顾

Pharmacy Education Pub Date : 2023-10-10 DOI: 10.46542/pe.2023.234.208218

Yugo Susanto, Liza Pristianty, Andi Hermansyah

引用次数: 0

The relationship of body mass index and T score in healthy and knee osteoarthritis women 健康及膝关节骨性关节炎女性体重指数与T评分的关系

Pharmacy Education Pub Date : 2023-10-10 DOI: 10.46542/pe.2023.234.321324

Anisyah Achmad, None Suharjono, Joewono Soeroso, Budi Suprapti, None Siswandono, Liza Pristianty, Mahardian Rahmadi, Jusak Nugraha, Yoki Surya, Satria Pandu Persada Isma, Erreza Rahadiansyah, Ilmia Fahmi, Catur Saptaning Wilujeng

{"title":"The relationship of body mass index and T score in healthy and knee osteoarthritis women","authors":"Anisyah Achmad, None Suharjono, Joewono Soeroso, Budi Suprapti, None Siswandono, Liza Pristianty, Mahardian Rahmadi, Jusak Nugraha, Yoki Surya, Satria Pandu Persada Isma, Erreza Rahadiansyah, Ilmia Fahmi, Catur Saptaning Wilujeng","doi":"10.46542/pe.2023.234.321324","DOIUrl":"https://doi.org/10.46542/pe.2023.234.321324","url":null,"abstract":"Background: Osteoarthritis (OA) is a chronic, degenerative, slowly progressive disease common in women with multiple aetiology. Osteoarthritis occurs simultaneously with the reduction in bone mineral density (BMD)while a high bone mass index (BMI) value is one of the risk factors for OA. Objective: The purpose of this study was to determine the effect of BMI and BMD in healthy and knee OA women. Method: The study was conducted in an orthopaedic outpatient clinic in 2021. This is a quantitative descriptive study with accidental cross-sectional samplings. The Mann-Whitney test was used to analyse the data. Result: Subjects included in the inclusion criteria obtained 74 OA and 49 control groups. The largest subjects in the OA group were aged 56-65 years old (32, 43.24%), obese (51, 68.92%), and post-menopause (49, 66.22%). At the same time, the T score category was normal (14, 18.91%), osteopenia (22, 29.73%), and osteoporosis (38, 51.35%). Statistical analysis found a significant relationship between BMI and BMD (p = 0.002, p = 0.001) in controls and OA groups. Conclusion: Disorders of BMI and BMD are indicators of risk for OA. High BMI and low BMD values occur in women with knee OA. There is a relationship between BMI and BMD in healthy and knee OA women.","PeriodicalId":19944,"journal":{"name":"Pharmacy Education","volume":"23 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136295553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Characteristics and communication skills of health professionals in implementing provider-initiated HIV testing and counselling (PITC) for Indonesian pregnant women 卫生专业人员在为印度尼西亚孕妇实施由提供者发起的艾滋病毒检测和咨询(PITC)方面的特点和沟通技巧

Pharmacy Education Pub Date : 2023-10-10 DOI: 10.46542/pe.2023.234.2226

Faiqatul Hikmah, Hari Basuki Notobroto, Shrimarti Rukmini Devy, Erwin Astha Triyono

{"title":"Characteristics and communication skills of health professionals in implementing provider-initiated HIV testing and counselling (PITC) for Indonesian pregnant women","authors":"Faiqatul Hikmah, Hari Basuki Notobroto, Shrimarti Rukmini Devy, Erwin Astha Triyono","doi":"10.46542/pe.2023.234.2226","DOIUrl":"https://doi.org/10.46542/pe.2023.234.2226","url":null,"abstract":"Background: HIV testing for pregnant women is an important test during pregnancy. HIV testing for pregnant women is a way to prevent mother-to-child HIV transmission. Objectives: To investigate the relationship between the characteristics and communication skills of health professionals while conducting provider-initiated HIV testing and counselling (PITC) for pregnant women. Methods: This was an observational study with a cross-sectional approach. The study was conducted at 23 public health centres with 80 health professionals who conduct PITC. The data was analysed using the Chi-Square test. Results: There was a correlation between the characteristics and communication skills of respondents. Relationships were observed between respondents trained on PITC and communication with patients during PITC sessions (p=0.002); work experience and non-verbal communication skills (p=0.047), and type of profession of respondents and non-verbal communication skills (p=0.029). Conclusions: Communication skills had a relationship with experienced training on PITC, work experience, and type of profession. Increasing the communication skill of health professionals through work experience and training or education to improve the ability of health professionals in PITC services.","PeriodicalId":19944,"journal":{"name":"Pharmacy Education","volume":"32 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136295557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Metabolite profiling of anticancer compounds in Saussure lappa based on UPLC-QToFMS/MS 基于UPLC-QToFMS/MS的雪莲抗癌化合物代谢谱分析

Pharmacy Education Pub Date : 2023-10-10 DOI: 10.46542/pe.2023.234.3742

Roihatul Mutiah, Ermin Rachmawati, Avin Ainur Fitrianingsih‬, Syayida Roisatus Zahiro

引用次数: 0

The profile of cold chain management of vaccines in primary healthcare centre in Kupang, Indonesia 印度尼西亚古邦初级卫生保健中心疫苗冷链管理概况

Pharmacy Education Pub Date : 2023-10-10 DOI: 10.46542/pe.2023.234.203207

Emanuel Gerald Alan Rahmat, None Yunita Nita, None Yuni Priyandani

{"title":"The profile of cold chain management of vaccines in primary healthcare centre in Kupang, Indonesia","authors":"Emanuel Gerald Alan Rahmat, None Yunita Nita, None Yuni Priyandani","doi":"10.46542/pe.2023.234.203207","DOIUrl":"https://doi.org/10.46542/pe.2023.234.203207","url":null,"abstract":"Background: Vaccine quality is strongly influenced by the cold chain application in vaccine storage and distribution at the Primary Healthcare Center. Objective: This study aimed to describe the cold chain management in storing and distributing vaccines at the Primary Healthcare Centre in the Kupang City area. Method: This study was a cross-sectional study. The data collection instrument used a checklist sheet containing 27 vaccine storage parameters and 8 (eight) vaccine distribution parameters. The research look at the vaccine storage and distribution. The sample uses the entire population, namely 11 Primary Healthcare Centre in the City of Kupang. Result: It was found that 19 vaccine storage criteria had been implemented in all Primary Healthcare Centre. Eight storage criteria had not been implemented in all Primary Healthcare Centre. Furthermore, in the distribution practice category of eight criteria, five of them had been implemented by all Primary Healthcare Center, while three criteria had not been met. Practice that need to be improved were in thermometer calibration, availability of storage and distribution SOPs, validation of delivery equipment, availability of storage room air circulation equipment. Conclusion: To conclude, the implementation of cold chain in vaccine storage and distribution practices in 11 sub-district healthcare centers was not optimal, therefore it needs to be improved.","PeriodicalId":19944,"journal":{"name":"Pharmacy Education","volume":"3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136295705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Alzheimer's disease from a diabetic brain: Exploring the molecular process to determine the potential therapy target from marine sources 来自糖尿病大脑的阿尔茨海默病:探索分子过程以确定来自海洋资源的潜在治疗靶点

Pharmacy Education Pub Date : 2023-10-10 DOI: 10.46542/pe.2023.234.189195

Arina Windri Rivarti, Legis Ocktaviana Saputri, Herpan Syafii Harahap, Lina Permatasari

{"title":"Alzheimer's disease from a diabetic brain: Exploring the molecular process to determine the potential therapy target from marine sources","authors":"Arina Windri Rivarti, Legis Ocktaviana Saputri, Herpan Syafii Harahap, Lina Permatasari","doi":"10.46542/pe.2023.234.189195","DOIUrl":"https://doi.org/10.46542/pe.2023.234.189195","url":null,"abstract":"Background: The prevalence of Alzheimer’s Disease (AD) among Type 2 Diabetes Mellitus (T2D) patients has reached almost 30%. Despite the rapid development, treatments for patients with T2D have not succeeded in controlling the neurodegenerative processes that occur in these patients' brains, leading to AD pathology. Several studies have demonstrated that marine sources can inhibit several AD pathogenesis pathways in T2D patients. This review aimed to determine the effect of marine species-sourced compounds at the molecular level in inhibiting and preventing the pathogenesis of AD in T2D patients. Method: Combinations of several terms were used to search for peer-reviewed literature published in PubMed, Scopus, and Google Scholar. Result: Marine organisms-sourced compounds inhibited various target signalling pathways between T2D and AD, such as an inhibitor of β-site-amyloid precursor protein cleaving enzyme 1 (BACE1) also known as β-secretase, glycogen synthase kinase-3 beta (GSK3B), insulin degradation enzyme (IDE), the mammalian target of rapamycin (mTOR), nuclear factor kappa-light-chain-enhancer (NF-κb), and nuclear factor erythroid 2-related factor 2 (Nrf2). Conclusion: Marine sources can be considered as a potential therapy to prevent or slow AD progression in T2D patients.","PeriodicalId":19944,"journal":{"name":"Pharmacy Education","volume":"251 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136352389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A study of the stability of antioxidant activity of green tea extract powder with vitamin C 含维生素C绿茶提取物粉末抗氧化活性稳定性的研究

Pharmacy Education Pub Date : 2023-10-10 DOI: 10.46542/pe.2023.234.159163

Djoko Agus Purwanto, Betria Dwi Agustin, Juni Ekowati

{"title":"A study of the stability of antioxidant activity of green tea extract powder with vitamin C","authors":"Djoko Agus Purwanto, Betria Dwi Agustin, Juni Ekowati","doi":"10.46542/pe.2023.234.159163","DOIUrl":"https://doi.org/10.46542/pe.2023.234.159163","url":null,"abstract":"Background: Green tea contains Epigallocatechin gallate (EGCG), the highest antioxidant activity. EGCG is an unstable compound due to degradation. Vitamin C is thought to be able to regenerate EGCG radicals into normal forms and increase green tea's antioxidant activity. Objective: The aim of this research was to determine the effect of adding vitamin C in maintaining the stability of the antioxidant activity of green tea. Method: This research was carried out by using UV-Vis spectrophotometry to determine the rate of decreasing antioxidant activity at 0 hours, six hours, and 24 hours by the 2,2-diphenyl-1-picrylhydrazyl (DPPH) method. Result: IC50 values of green tea before and after the addition of vitamin C were obtained at 147.53 ppm and 97.75 ppm, respectively. The degradation rate of green tea before and after the addition of vitamin C was 0.4228 %/hour and 0.3231 %/hour, respectively. Conclusion: The antioxidant activity of green tea with vitamin C is greater than without vitamin C addition. The degradation rate of green tea with vitamin C is smaller than green tea only, so the authors suggest the addition of vitamin C to green tea extract powder products to increase the stability of its antioxidant activity.","PeriodicalId":19944,"journal":{"name":"Pharmacy Education","volume":"31 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136352755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Factors that contribute to blood sugar control in type 2 diabetes mellitus 有助于控制2型糖尿病患者血糖的因素

Pharmacy Education Pub Date : 2023-10-10 DOI: 10.46542/pe.2023.234.4852

Gusti Noorrizka Veronika Achmad, Lea Nanda Yufria, Abdul Rahem, Liza Pristianty

{"title":"Factors that contribute to blood sugar control in type 2 diabetes mellitus","authors":"Gusti Noorrizka Veronika Achmad, Lea Nanda Yufria, Abdul Rahem, Liza Pristianty","doi":"10.46542/pe.2023.234.4852","DOIUrl":"https://doi.org/10.46542/pe.2023.234.4852","url":null,"abstract":"Background: Diabetes needs to be well controlled so as not to cause acute and chronic complications. Therefore, it is necessary to comply with regimen therapy and control diet and physical exercise. Objective: This study aimed to assess the contribution of medication adherence and nonpharmacological therapy adherence, as well as other factors affecting blood sugar control. Method: This study involved 76 type 2 diabetic patients from a Community Health Center in East Surabaya. Medication adherence was measured with an ARMS questionnaire and pill count, while nonpharmacological therapy was measured with a self-developed questionnaire. Result: The majority of respondents have uncontrolled blood sugar levels, were not compliant with treatment both as measured by ARMS and by the pill count method, and are not compliant with nonpharmacological therapy with the following frequencies: 85.5% (n=65), 92.1% (n=70), 57.9% (n=44), 98.7% (n=75). The results of multiple correlation tests showed that age, duration of treatment, adherence to treatment with the ARMS method and the pill count method, and adherence to nonpharmacological therapy simultaneously affected blood sugar control by 72.7%. Conclusion: Factors that simultaneously determine poor blood sugar control are age, duration of diabetes therapy, non-adherence to treatment, and non-adherence to nonpharmacological therapy.","PeriodicalId":19944,"journal":{"name":"Pharmacy Education","volume":"29 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136353230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Computational docking toward cox-2 and synthesis of 4-formyl-2-methoxyphenyl-4-chlorobenzoate using microwave irradiation 对cox-2的计算对接及微波辐射合成4-甲酰基-2-甲氧基苯基-4-氯苯甲酸酯

Pharmacy Education Pub Date : 2023-10-10 DOI: 10.46542/pe.2023.234.132136

Melanny Ika Sulistyowaty, Juni Ekowati, Steven Guitomo, Imamatin Nufus Melania, Muhammad Ilham Royyan Nafi

{"title":"Computational docking toward cox-2 and synthesis of 4-formyl-2-methoxyphenyl-4-chlorobenzoate using microwave irradiation","authors":"Melanny Ika Sulistyowaty, Juni Ekowati, Steven Guitomo, Imamatin Nufus Melania, Muhammad Ilham Royyan Nafi","doi":"10.46542/pe.2023.234.132136","DOIUrl":"https://doi.org/10.46542/pe.2023.234.132136","url":null,"abstract":"Background: Structure modification of organic compounds is needed to increase their bioactivity. Vanillin has been reported to has various therapeutic effects such as antioxidant, antimutagenic, anti-invasive and metastatic suppression potential, anti-inflammatory and also antinociceptive activity. To increase the activity of organic compounds, we have to enhance the lipophilic properties by modifications of the structure. Objective: The phenolic OH of vanillin can be modified by adding aromatic ring, carbonyl, and halogen to improve its bioactivity. The 4-formyl-2-methoxyphenyl-4-chlorobenzoate is a vanillin derivative that has been modified to its phenolic –OH. Method: In this study, the synthesis of 4-formyl-2-methoxyphenyl-4-chlorobenzoate was carried out by microwave irradiation with various power of 120, 200 and also 400 watt. The characterizations of the synthesized compound were carried out using FTIR, 1H-NMR and 13C-NMR spectrophotometry. The molecular docking study used Autodock software with at the COX-2 receptor (PDB ID: 6COX) as target receptor. Result: We used the microwave’s power of 120, 200 and also 400 watt to synthesis the target compound and produced 89.09%, 72.78% and 34.49% yield, consecutively. Molecular docking study at the COX-2 receptors was performed to predict the anti-inflammatory activity of 4-formyl-2-methoxyphenyl-4-chlorobenzoate. The docking results showed that the binding energy of 4-formyl-2-methoxyphenyl-4-chlorobenzoate was lower on chain A of the receptor (-8.18 kcal/mol) than the starting material, vanillin (-4.96 kcal/mol). It predicted 4-formyl-2-methoxyphenyl-4-chlorobenzoate has better activity than vanillin. Conclusion: The 4-formyl-2-methoxyphenyl-4-chlorobenzoate was successfully synthesized and this finding proves that this compound essentials to be developed furthermore as an anti-inflammatory agent.","PeriodicalId":19944,"journal":{"name":"Pharmacy Education","volume":"52 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136353356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Therapy pattern of bronchodilators in chronic obstructive pulmonary disease (COPD) patients with acute exacerbations 慢性阻塞性肺疾病(COPD)急性加重期支气管扩张剂的治疗模式

Pharmacy Education Pub Date : 2023-10-10 DOI: 10.46542/pe.2023.234.224227

Samirah Samirah, Toetik Aryani, Arina Dery Puspitasari, Marisa Anggia Ibrahim, Bunga Izzatul Lutfiyah, Alfian Nur Rasyid

{"title":"Therapy pattern of bronchodilators in chronic obstructive pulmonary disease (COPD) patients with acute exacerbations","authors":"Samirah Samirah, Toetik Aryani, Arina Dery Puspitasari, Marisa Anggia Ibrahim, Bunga Izzatul Lutfiyah, Alfian Nur Rasyid","doi":"10.46542/pe.2023.234.224227","DOIUrl":"https://doi.org/10.46542/pe.2023.234.224227","url":null,"abstract":"Background: Acute exacerbation of chronic obstructive pulmonary disease (COPD) is a worsening condition of acute respiratory symptoms caused by microbial infection, increased air pollution, and fatigue. Objective: This study determines the pattern of bronchodilators in patients with acute exacerbations of COPD. Method: This study was observational, using the health medical records of patients with COPD at the Universitas Airlangga Hospital, Surabaya. It was conducted between January-December 2019 on male patients who received bronchodilator therapy until discharge and were from age 40 and older. Result: A total of 48 patients met the inclusion criteria. The most commonly used bronchodilator therapy for inpatients was the combination of ipratropium bromide/salbutamol sulfate 0.5 mg/2.5 mg through inhalation in 63.64%. The most frequently used bronchodilator for discharge was salbutamol sulfate 2-4 mg orally in 87.50%. Conclusion: Therapy for acute exacerbation of COPD using a combination of ipratropium bromide/salbutamol sulfate as a preventive therapy is in line with the GOLD guidelines.","PeriodicalId":19944,"journal":{"name":"Pharmacy Education","volume":"17 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136353505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0