Gita Nola Sri Haestuti, Nanda Puspita, Khairun Nida
{"title":"Assessing knowledge and practice of online medication purchasing: A pilot study","authors":"Gita Nola Sri Haestuti, Nanda Puspita, Khairun Nida","doi":"10.46542/pe.2024.243.260265","DOIUrl":"https://doi.org/10.46542/pe.2024.243.260265","url":null,"abstract":"Background: Online Medication Purchasing (OMP) has emerged as a growing concern because of the risk of receiving falsified products and the irrational use of medicines. Despite the government regulation about OMP, more is needed to know whether the residents are aware of this regulation.\u0000Objective: The study aimed to determine the level of knowledge & practice of OMP and to estimate the factors correlated to it.\u0000Method: A pilot project was conducted in the Wanasari village, Cibitung district, Bekasi. A validated questionnaire determined the sociodemographics, knowledge, and practice of 92 participants regarding OMP. A multivariate logistic regression was performed to measure the predictors of OMP knowledge.\u0000Result: The study showed that slightly over half of the participants have adequate knowledge of OMP (58.7%). Nevertheless, poor knowledge predominantly emerged regarding legal access to antibiotics and controlled medicines. Adequate knowledge of OMP increased for participants with higher education (OR:20.202; 95%CI:3.488-117.020; p = 0.001) and being active workers (OR:8.365; 95%CI:1.974-35.435; p = 0.004).\u0000Conclusion: Education and employment determine OMP knowledge. This study confirms that educational interventions are required to promote good OMP practice and protect health customers from the adverse effects of falsified medications.","PeriodicalId":19944,"journal":{"name":"Pharmacy Education","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2024-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141012166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
J. N. Al-Maamari, Ahmed A Al-Qubati, J. Khotib, M. Rahmadi
{"title":"Immunotherapies for food allergy: Exploring new targets and innovative strategies for enhanced efficacy","authors":"J. N. Al-Maamari, Ahmed A Al-Qubati, J. Khotib, M. Rahmadi","doi":"10.46542/pe.2024.243.266272","DOIUrl":"https://doi.org/10.46542/pe.2024.243.266272","url":null,"abstract":"Food allergy is a growing public health concern. It affects children and adults, resulting in significant declines in the overall quality of life. In most cases, individuals must avoid consuming allergenic foods, which can be challenging, especially for patients who experience life-threatening symptoms even with minimal exposure to allergens. This review aimed to identify promising targets for immunotherapy in food allergy, strategies to reduce adverse reactions and side effects, optimal dosing approaches, clinical endpoints to measure efficacy, patient subgroups that benefit, and barriers to implementing immunotherapy. An in-depth literature review was conducted using PubMed and Google Scholar to look into novel approaches and possible targets for enhancing the effectiveness of immunotherapy. Targeting specific immune cells and molecules (e.g., IgE and Tregs), lowering the doses of allergens, extending intervals between doses, personalising dosing, selecting eligible patients carefully, and validating clinical endpoints have shown promising results in overcoming food allergy challenges and increasing immunotherapy efficacy. Potential innovative strategies to enhance immunotherapy efficacy encompass developing more cost-effective approaches, increasing access to trained specialists, developing standardised protocols, and collecting long-term data.","PeriodicalId":19944,"journal":{"name":"Pharmacy Education","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2024-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141011543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The readiness and acceptance of patients with tuberculosis to use telecare","authors":"Devianty Octavia, Andi Hermansyah, Y. Nita","doi":"10.46542/pe.2024.243.251255","DOIUrl":"https://doi.org/10.46542/pe.2024.243.251255","url":null,"abstract":"Background: Tuberculosis (TB) has been a global health burden and a leading infectious killer. The evolving healthcare technology allows telecare services to improve treatment support for TB patients. However, patient readiness and acceptance to use the service still need to be discovered.\u0000Objective: To evaluate the readiness and acceptance of TB patients in using telecare services. \u0000Methods: A cross-sectional survey involving patients at a respiratory hospital in Surabaya, Indonesia, was conducted using an accidental sampling technique from April to June 2023. A validated questionnaire was developed from the technology readiness index (TRI) and technology acceptance model (TAM) framework. Data were analysed using partial least squares-structural equation modelling (PLS-SEM). \u0000Results: A total of 188 respondents participated. Respondents had low to medium-range attitudes towards a readiness to use the telecare service. Nevertheless, the majority of the respondents accepted the idea of telecare service. Optimism and innovativeness were two significant factors influencing patient readiness to use telecare services. Respondents had a positive perception of the perceived ease of use and perceived usefulness of the service.\u0000Conclusion: Not all patients were ready to use telecare despite their high acceptance towards the service. However, the positive perception towards the benefits of the service can be the leveraging factor for gradually adopting the service.","PeriodicalId":19944,"journal":{"name":"Pharmacy Education","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2024-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141013974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Arina Dery Puspitasari, Anita Nur Azizah, W. Nilamsari, Robby Nurhariansyah, Ika Nursetyo Palupi
{"title":"Utilisation study of antipyretic drugs in paediatric patients","authors":"Arina Dery Puspitasari, Anita Nur Azizah, W. Nilamsari, Robby Nurhariansyah, Ika Nursetyo Palupi","doi":"10.46542/pe.2024.243.234239","DOIUrl":"https://doi.org/10.46542/pe.2024.243.234239","url":null,"abstract":"Background: Fevers are common in children with underlying diseases, so antipyretics are often used. However, no specific guidelines exist for the use of antipyretics in children.\u0000Objective: This study aimed to determine the profile of antipyretics used by paediatric inpatients at Universitas Airlangga Hospital and to identify possible side effects and interactions associated with antipyretics use.\u0000Method: This observational study was conducted from March to June 2023. Convenience sampling was used to collect retrospective data from patients’ medical records, which were then analysed descriptively.\u0000Result: A total of 87 paediatric patients met the inclusion criteria. All paediatric patients received intravenous metamizole as an antipyretic treatment (100.0%), with 3 x 8 - 20 mg/kgBW as needed (55.2%) being the most used dosage regimen. Metamizole as monotherapy was the most widely used pattern (80.5%), and it showed the shortest mean duration of therapy. Paracetamol was only used in switching (11.5%) and alternating (8.1%) patterns. Abdominal pain was the most actual suspected side effect of metamizole (3.4%). No potential drug interactions associated with antipyretics were found.\u0000Conclusion: In general, intravenous metamizole effectively reduced fever in most paediatric patients at Universitas Airlangga Hospital.","PeriodicalId":19944,"journal":{"name":"Pharmacy Education","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141035552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Vitarani Dwi, Ananda Ningrum, Adib Samudra Putra, Lusiana Rahmadiyah Panggabean, Martania Pratiwi, M. Y. Zainudin, Sarah Kulsum Toyyibah, Ulyatul Khoiroh, Andika Dwi Mahendra, Mitha Dwi Puspitasari, Rusmina Iswanti, Kumala Dewi
{"title":"Analysis of drug-related problems in the home medication review practice by the master of pharmacy students","authors":"Vitarani Dwi, Ananda Ningrum, Adib Samudra Putra, Lusiana Rahmadiyah Panggabean, Martania Pratiwi, M. Y. Zainudin, Sarah Kulsum Toyyibah, Ulyatul Khoiroh, Andika Dwi Mahendra, Mitha Dwi Puspitasari, Rusmina Iswanti, Kumala Dewi","doi":"10.46542/pe.2024.243.222227","DOIUrl":"https://doi.org/10.46542/pe.2024.243.222227","url":null,"abstract":"Background: Master’s students are required to perform community service (CS), so a strategy is needed to merge CS into a course and make it a learning method that can be sustainably evaluated.\u0000Objective: This study aimed to analyse patients’ problems in using, storing, and disposing of drugs through home medication review (HMR) by master’s students of pharmacy. Subjective self-assessment assesses students’ performance in fulfilling the relevant competencies.\u0000Method: This cross-sectional study, conducted for four months, involved 225 patients living near the students’ residences. Semi-structured interviews collected data on subject characteristics and how the patients/family members managed drugs at home.\u0000Result: Nine master’s students practised HMR to achieve the learning outcomes of the pharmaceutical care course. The most commonly identified drug-related problems (DRPs) were inappropriate timing or dosing interval (41.2%) and medication nonadherence (25%). Some patients (31.6%) stored drugs without adherence to the provisions, and 70.2% disposed of drugs directly in the trash can. Meanwhile, 88.9% of students strongly agreed that HMR could improve their ability to gather patient data and information.\u0000Conclusion: HMR is an excellent patient-oriented practice for master’s students to strengthen and refine their awareness of community needs regarding drug use and management by patients at home.","PeriodicalId":19944,"journal":{"name":"Pharmacy Education","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141043094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Vancomycin bioanalysis for TDM services by using immunoassay and HPLC: A scoping review","authors":"V. Ningrum, Senya Puteri Amalia, Ari Wibowo","doi":"10.46542/pe.2024.243.197203","DOIUrl":"https://doi.org/10.46542/pe.2024.243.197203","url":null,"abstract":"Background: Administration of vancomycin in treating infections caused by Methicillin-resistant Staphylococcus aureus (MRSA) requires therapeutic drug monitoring (TDM). The immunoassay method and high-performance liquid chromatography (HPLC) are the two methods of choice for examining vancomycin levels, with their respective advantages.\u0000Objective: This study aims to review the validity of immunoassay and HPLC methods, as well as consider which method is appropriate, effective, and efficient for TDM in the clinical setting.\u0000Method: Related articles were searched for using the keywords \"immunoassay\", \"vancomycin\", \"HPLC\", \"bioanalysis\", and \"human\" in the PubMed, Google Scholar, and Science Direct databases.\u0000Result: A total of 20 publications examined immunoassays, whereas 23 articles covered HPLC. Both the immunoassay and HPLC methods provided acceptable bioanalytical validation values.\u0000Conclusion: The immunoassay method is an option for routine sample analysis that requires fast results, but this method is not recommended for patients with high immunoglobulin levels. The HPLC method is a choice because it offers better selectivity and sensitivity.","PeriodicalId":19944,"journal":{"name":"Pharmacy Education","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141044474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Gusti Agung, Putu Deddy Mahardika, Y. Nita, Y. Priyandani
{"title":"A comparative study of real hospital costs and INA-CBG rates for stroke in Indonesia","authors":"Gusti Agung, Putu Deddy Mahardika, Y. Nita, Y. Priyandani","doi":"10.46542/pe.2024.243.166172","DOIUrl":"https://doi.org/10.46542/pe.2024.243.166172","url":null,"abstract":"Background: The claim payment method in JKN program uses the prospective Indonesian Case Base Groups (INA-CBG) method, in which the rate has been determined before health services are provided based on the diagnosis code group. This potentially causes a discrepancy in the costs incurred by health facilities.\u0000Objective: This systematic review aimed to provide an overview of the comparison of actual hospital costs with the INA-CBG rates of the JKN program for inpatient stroke.\u0000Method: The collection method used a PRISMA flowchart on several databases. This systematic review is a comparative study comparing the significance of the average actual direct medical costs with the INA-CBG rates.\u0000Result: Cost differences on intracerebral haemorrhage (I619) and unspecified stroke diagnosis (I64) consistently give a negative difference around IDR 110,659 – IDR 8,184,007/patient/episode. Medicine and medical equipment are the most significant components of stroke treatments. Factors that significantly influence direct medical costs are the length of stay (LOS), class of JKN, and age.\u0000Conclusion: Cost differences can be influenced by several factors that can affect the direct medical costs of hospitals. The factor that has the most influence on the amount of direct medical cost is LOS.","PeriodicalId":19944,"journal":{"name":"Pharmacy Education","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141042937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
I. Y. Ningsih, M. A. Hidayat, T. Erawati, B. Kuswandi
{"title":"Impact of different NaOH treatments on biocellulose properties from coconut water fermented by Lentilactobacillus parafarraginis","authors":"I. Y. Ningsih, M. A. Hidayat, T. Erawati, B. Kuswandi","doi":"10.46542/pe.2024.243.7581","DOIUrl":"https://doi.org/10.46542/pe.2024.243.7581","url":null,"abstract":"Background: Biocellulose is a natural polymer produced by bacteria with distinct physicochemical properties, although it has a chemical composition identical to plant cellulose. Before use, biocellulose was purified by chemical treatment to increase its properties.\u0000Objective: The study aimed to evaluate biocellulose properties using NaOH solution as a purification agent.\u0000Method: After harvesting, all samples were purified using NaOH of 0.25 M (BC0.25), 0.5 M (BC0.5), and 1 M (BC1) and determined for their properties, such as mechanical strength, swelling degree, water vapour transmission, and moisture content. Analysis of scanning electron microscope (SEM) images and Fourier Transform Infrared Spectroscopy (FTIR) spectra were also performed for characterisation.\u0000Result: BC0.5 exhibited the highest tensile strength of 15.38±0.45 MPa and elongation at a break of 38.40±0.58%. BC1 had the highest swelling degree of 131.24±0.70%, water vapour transmission of 400.00±0.36 g/m2, and moisture content of 6.44±0.14%. Nevertheless, there were slight alterations in morphological structure and spectral peaks because of the high concentration of NaOH.\u0000Conclusion: The use of NaOH treatment of 0.5 M in biocellulose purification removed more contaminants and resulted in better properties than other concentrations.","PeriodicalId":19944,"journal":{"name":"Pharmacy Education","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141024250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"In silico approach of Garcinia mangostana and Ortosiphon stamineus to restore adipokines level as drug candidate for metabolic syndrome","authors":"D. Indiastuti, Nada Salsabila, Bellinda Zalzabillah Tazkira, Arifa Mustika, Suharjono, Sukardiman","doi":"10.46542/pe.2024.243.159165","DOIUrl":"https://doi.org/10.46542/pe.2024.243.159165","url":null,"abstract":"Background: Metabolic syndrome is a group of metabolic disorders due to dysfunctional adipose tissue. Adipose tissue is an endocrine organ that secretes many pro-inflammatory and anti-inflammatory adipokines. Garcinia mangostana and Orthosiphon stamineus have demonstrated various pharmacological effects, including antidiabetic, anti-dyslipidemia, antiobesity, antioxidant, and anti-inflammatory properties.\u0000Objective: This study aimed to analyse the interaction of phytochemical compounds from Garcinia mangostana and Orthosiphon stamineus in decreasing levels of pro-inflammatory adipokines while increasing levels of anti-inflammatory adipokines.\u0000Method: This research is an in silico study of phytochemical compounds from Garcinia mangostana and Orthosiphon stamineus retrieved from PubChem and HMDB. Adipokines as target proteins were obtained from RCSB and UniProt.\u0000Result: Mangostanin, mangostanol, and mangostinone from Garcinia mangostana, as well as ladanein, salveginin, sinensetin, and rosmarinic acid from Orthosiphon stamineus, exhibited stable molecular complexes compared to other compounds.\u0000Conclusion: Phytochemical compounds from Garcinia mangostana and Orthosiphon stamineus show potential as candidates for metabolic syndrome drugs by restoring adipokine levels. However, further research is still needed.","PeriodicalId":19944,"journal":{"name":"Pharmacy Education","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141025524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nyoman Wijaya, U. Athiyah, Andi Fasich, Hermansyah, I. N. Wijaya
{"title":"Practice module training to increase pharmacist knowledge and skills in identifying drug therapy problems in hypertensive patients","authors":"Nyoman Wijaya, U. Athiyah, Andi Fasich, Hermansyah, I. N. Wijaya","doi":"10.46542/pe.2024.243.8287","DOIUrl":"https://doi.org/10.46542/pe.2024.243.8287","url":null,"abstract":"Background: Pharmacists are responsible for drug therapy given to patients to achieve therapeutic results in pharmaceutical services. Various studies state that there are still many hypertension sufferers who have not reached the target of therapy. This happens because there are still many problems with drug therapy.\u0000Aim: This study aimed to increase pharmacists' knowledge and skills in identifying drug therapy problems (DTP) in hypertensive patients at primary care centres (PHCs).\u0000Method: This study was attended by forty PHC pharmacists in the Surabaya area. The research was conducted in May-August 2020, with a pre-and post-test control group design. The research sample consisted of 20 pharmacists in the treatment group and 20 in the control group. The different test was carried out with the Wilcoxon test.\u0000Result: The results showed a difference between the pre-and post-test results of pharmacist knowledge (p < 0.05), indicating increased pharmacists’ knowledge. There were differences in the skills of pharmacists in collecting patient demographic data, finding DTP, and conducting intervention (p < 0.05).\u0000Conclusion: Practice module training can improve pharmacists’ knowledge and skills in identifying DTP.","PeriodicalId":19944,"journal":{"name":"Pharmacy Education","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141028071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}