Nanomaterials最新文献_第6页

Skin Sensitization Potential of Sensitizers in the Presence of Metal Oxide Nanoparticles In Vitro. 体外金属氧化物纳米颗粒存在时敏化剂的皮肤敏化潜能。

IF 4.4 3区材料科学

Nanomaterials Pub Date : 2024-11-12 DOI: 10.3390/nano14221811

Claudia Meindl, Kristin Öhlinger, Verena Zrim, Jennifer Ober, Ramona Jeitler, Eva Roblegg, Eleonore Fröhlich

{"title":"Skin Sensitization Potential of Sensitizers in the Presence of Metal Oxide Nanoparticles In Vitro.","authors":"Claudia Meindl, Kristin Öhlinger, Verena Zrim, Jennifer Ober, Ramona Jeitler, Eva Roblegg, Eleonore Fröhlich","doi":"10.3390/nano14221811","DOIUrl":"10.3390/nano14221811","url":null,"abstract":"Silica (SiO2), titanium dioxide (TiO2), and zinc oxide (ZnO) nanoparticles (NPs) are widely used in dermal products. Their skin sensitization potential, especially their effects in combination with known sensitizers, is poorly studied in vitro and their sensitization inconsistently reported in animal studies. In this study, cellular assays were used to identify different steps of sensitization, the activation of keratinocytes and dendritic cells, when cells were exposed to these NPs in the absence and presence of sensitizers. Cellular systems included HaCaT keratinocytes and U937 (U-SENS™) alone, as well as different co-culture systems of THP-1 cells with HaCaT cells (COCAT) and with primary keratinocytes. The effect of NPs differed between co-cultures and U-SENS™, whereas co-cultures with either primary keratinocytes or HaCaT cells responded similarly. Pre-exposure to ZnO NPs increased the U-SENS™ assay response to 2,4-dinitrochlorobenzene six-fold. The COCAT increase was maximally four-fold for the combination of SiO2 and trans cinnamaldehyde. When the THP-1 cells were separated from the keratinocytes by a membrane, the response of the co-culture system was more similar to U-SENS™. The direct contact with keratinocytes decreased the modulating effect of TiO2 and ZnO NPs but suggested an increase in response to sensitizers following dermal contact with SiO2 NPs.","PeriodicalId":18966,"journal":{"name":"Nanomaterials","volume":"14 22","pages":""},"PeriodicalIF":4.4,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11597535/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142730857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthesis of TiO₂-ZnO n-n Heterojunction with Excellent Visible Light-Driven Photodegradation of Tetracycline. 合成具有优异可见光光降解四环素能力的 TiO2-ZnO n-n 异质结

IF 4.4 3区材料科学

Nanomaterials Pub Date : 2024-11-11 DOI: 10.3390/nano14221802

Ying Zhang, Xinkang Bo, Tao Zhu, Wei Zhao, Yumin Cui, Jianguo Chang

{"title":"Synthesis of TiO2-ZnO n-n Heterojunction with Excellent Visible Light-Driven Photodegradation of Tetracycline.","authors":"Ying Zhang, Xinkang Bo, Tao Zhu, Wei Zhao, Yumin Cui, Jianguo Chang","doi":"10.3390/nano14221802","DOIUrl":"10.3390/nano14221802","url":null,"abstract":"Zinc oxide-based photocatalysts with non-toxicity and low cost are promising candidates for the degradation of tetracycline. Despite the great success achieved in constructing n-n-type ZnO-based heterojunctions for the degradation of tetracycline under full-spectrum conditions, it is still challenging to realize rapid and efficient degradation of tetracycline under visible light using n-n-type ZnO-based heterojunctions, as they are constrained by the quick recombination of electron-hole pairs in ZnO. Here, we report highly efficient and stable n-n-type ZnO-TiO2 heterojunctions under visible light conditions, with a degradation efficiency reaching 97% at 1 h under visible light, which is 1.2 times higher than that of pure zinc oxide, enabled by constructing an n-n-type heterojunction between ZnO and TiO2 to form a built-in electric field. The photocatalytic degradation mechanism of n-n TiO2-ZnO to tetracycline is also proposed in detail. The demonstration of efficient and stable heterojunction-type ZnO photocatalysts under visible light is an important step toward commercialization and opens up new opportunities beyond conventional ZnO technologies, such as composite ZnO catalysts.","PeriodicalId":18966,"journal":{"name":"Nanomaterials","volume":"14 22","pages":""},"PeriodicalIF":4.4,"publicationDate":"2024-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11597633/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142730817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Tuneable and Easy-to-Prepare SERS Substrate Based on Ag Nanorods: A Versatile Tool for Solution and Dry-State Analyses. 基于银纳米棒的可调且易于制备的 SERS 基底：溶液和干态分析的多功能工具

IF 4.4 3区材料科学

Nanomaterials Pub Date : 2024-11-11 DOI: 10.3390/nano14221808

Margherita Longoni, Sofia Zucca, Silvia Bruni

{"title":"A Tuneable and Easy-to-Prepare SERS Substrate Based on Ag Nanorods: A Versatile Tool for Solution and Dry-State Analyses.","authors":"Margherita Longoni, Sofia Zucca, Silvia Bruni","doi":"10.3390/nano14221808","DOIUrl":"10.3390/nano14221808","url":null,"abstract":"Surface-enhanced Raman spectroscopy is a powerful technique for the ultra-sensitive detection of organic analytes. In this paper, the preparation of SERS substrates based on silver nanorods (AgNRs) is proposed, exploiting a simple protocol which does not require complex procedures and/or sophisticated and expensive instrumentation. For this purpose, various syntheses of AgNRs were tested, and the best one for preparing the SERS active substrate proved to be the one which does not involve surfactants as nanoparticle stabilizers. The plasmonic properties of the selected substrate can be modified based on the concentration of the deposited nanoparticles, allowing for the experimentation of different excitation wavelengths. Positive results were obtained on reference solutions of three natural dyes of historical interest using both green exciting radiation (532 nm) and two near-infrared ones (785 and 850 nm; the latter is combined with the SSE™ technology for further fluorescence quenching). Furthermore, the substrates of AgNRs were found to be suitable for SERS measurements even in dry-state conditions, i.e., only exploiting the electromagnetic interaction between the nanostructured substrate and the dye molecules absorbed onto a wool fibre.","PeriodicalId":18966,"journal":{"name":"Nanomaterials","volume":"14 22","pages":""},"PeriodicalIF":4.4,"publicationDate":"2024-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11597580/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142730755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparative Analysis of Thin and Thick MoTe₂ Photodetectors: Implications for Next-Generation Optoelectronics. 薄型和厚型 MoTe2 光电探测器的比较分析：对下一代光电子学的影响。

IF 4.4 3区材料科学

Nanomaterials Pub Date : 2024-11-11 DOI: 10.3390/nano14221804

Saddam Hussain, Shaoguang Zhao, Qiman Zhang, Li Tao

{"title":"Comparative Analysis of Thin and Thick MoTe2 Photodetectors: Implications for Next-Generation Optoelectronics.","authors":"Saddam Hussain, Shaoguang Zhao, Qiman Zhang, Li Tao","doi":"10.3390/nano14221804","DOIUrl":"10.3390/nano14221804","url":null,"abstract":"Due to its outstanding optical and electronic properties, molybdenum ditelluride (MoTe2) has become a highly regarded material for next-generation optoelectronics. This study presents a comprehensive, comparative analysis of thin (8 nm) and thick (30 nm) MoTe2-based photodetectors to elucidate the impact of thickness on device performance. A few layers of MoTe2 were exfoliated on a silicon dioxide (SiO2) dielectric substrate, and electrical contacts were constructed via EBL and thermal evaporation. The thin MoTe2-based device presented a maximum photoresponsivity of 1.2 A/W and detectivity of 4.32 × 108 Jones, compared to 1.0 A/W and 3.6 × 108 Jones for the thick MoTe2 device at 520 nm. Moreover, at 1064 nm, the thick MoTe2 device outperformed the thin device with a responsivity of 8.8 A/W and specific detectivity of 3.19 × 109 Jones. Both devices demonstrated n-type behavior, with linear output curves representing decent ohmic contact amongst the MoTe2 and Au/Cr electrodes. The enhanced performance of the thin MoTe2 device at 520 nm is attributed to improved carrier dynamics resulting from effective electric field penetration. In comparison, the superior performance of the thick device at 1064 nm is due to sufficient absorption in the near-infrared range. These findings highlight the importance of thickness control in designing high-performance MoTe2-based photodetectors and position MoTe2 as a highly suitable material for next-generation optoelectronics.","PeriodicalId":18966,"journal":{"name":"Nanomaterials","volume":"14 22","pages":""},"PeriodicalIF":4.4,"publicationDate":"2024-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11597147/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142730792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Micromechanics Modeling on Mechanical Properties in Mg Alloys with Bimodal Grain Size Distribution. 具有双峰晶粒尺寸分布的镁合金力学性能的微观力学模型

IF 4.4 3区材料科学

Nanomaterials Pub Date : 2024-11-11 DOI: 10.3390/nano14221807

Shaojie Li, Jianfeng Jin, Hao Sun, Yongbo Wang, Yuping Ren, Mingtao Wang, Gaowu Qin

{"title":"Micromechanics Modeling on Mechanical Properties in Mg Alloys with Bimodal Grain Size Distribution.","authors":"Shaojie Li, Jianfeng Jin, Hao Sun, Yongbo Wang, Yuping Ren, Mingtao Wang, Gaowu Qin","doi":"10.3390/nano14221807","DOIUrl":"10.3390/nano14221807","url":null,"abstract":"Bimodal grain structure (BGS) Mg alloys containing a high fraction of fine grains (FGs) and a low fraction of coarse grains (CGs) show a good combination of strength and plasticity. Here, taking the ZK60 alloy as an example, the influences of CG size, volume fraction, and texture intensity on mechanical properties and the hetero-deformation-induced (HDI) effect were examined using the Mori-Tanaka mean-field method combined with strain gradient theory of plasticity. The results indicate that the overall mechanical properties decrease with an increase in CG size because the limited HDI effect cannot compensate for the strength and plasticity decrease derived from larger CGs. A higher aspect ratio of CG along the loading direction can weaken the HDI effect and subsequently reduce the overall mechanical properties. Optimal comprehensive mechanical properties can be achieved when the CG volume fraction is approximately 30%. Furthermore, an increasing basal texture intensity in CG results in higher yield strength and lower ultimate tensile strength, while the uniform elongation reaches a maximum value when ~60% of CGs possess hard orientations with Euler angles of (0~30°, 0°, 0°).","PeriodicalId":18966,"journal":{"name":"Nanomaterials","volume":"14 22","pages":""},"PeriodicalIF":4.4,"publicationDate":"2024-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11597807/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142730764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Effect of Solute Elements Co-Segregation on Grain Boundary Energy and the Mechanical Properties of Aluminum by First-Principles Calculation. 利用第一性原理计算溶质元素共析对铝晶界能和机械性能的影响

IF 4.4 3区材料科学

Nanomaterials Pub Date : 2024-11-11 DOI: 10.3390/nano14221803

Xuan Zhang, Yuxuan Wan, Cuifan Chen, Liang Zhang

{"title":"The Effect of Solute Elements Co-Segregation on Grain Boundary Energy and the Mechanical Properties of Aluminum by First-Principles Calculation.","authors":"Xuan Zhang, Yuxuan Wan, Cuifan Chen, Liang Zhang","doi":"10.3390/nano14221803","DOIUrl":"10.3390/nano14221803","url":null,"abstract":"The segregation of solute atoms at grain boundary (GB) has an important effect on the GB characteristics and the properties of materials. The study of multielement co-segregation in GBs is still in progress and deserves further research at the atomic scale. In this work, first-principles calculations were carried out to investigate the effect of Mg and Cu co-segregation on the energetic and mechanical properties of the Al Σ5(210) GB. The segregation tendency of Mg at the GB in the presence of Cu is characterized, indicating a preference for substitutional segregation far away from Cu atoms. Cu segregation can facilitate the segregation of Mg due to their mutual attractive energy. The GB energy results show that Mg and Cu co-segregation significantly decreases GB energy and thus enhances the stability of the Al Σ5(210) GB. First-principles tensile test calculations indicate that Cu effectively counteracts the weakening effect of Mg segregation in the GB, particularly with the high concentration of Cu segregation. The phenomenon of Cu compensating the strength of the GB is attributed to an increase of charge density and the formation of newly formed Cu-Al bonds. Conversely, Mg segregation weakens the strengthening effect of Cu on the GB, but it can increase the strength of the GB when high concentrations of Cu atoms are present in the GB. The ICOHP and Bader charge analysis exhibits that the strengthening effect of Mg is attributed to charge transfer with surrounding Al and Cu, which enhances the Cu-Al and Al-Al bonds. The results provide a further understanding of the interplay between co-segregated elements and its influence on the energetic and mechanical properties of grain boundary.","PeriodicalId":18966,"journal":{"name":"Nanomaterials","volume":"14 22","pages":""},"PeriodicalIF":4.4,"publicationDate":"2024-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11597672/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142730819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Structural, Mechanical, and Optical Properties of Laminate-Type Thin Film SWCNT/SiO_xN_y Composites. 层压式薄膜 SWCNT/SiOxNy 复合材料的结构、机械和光学特性。

IF 4.4 3区材料科学

Nanomaterials Pub Date : 2024-11-11 DOI: 10.3390/nano14221806

Elizaveta Shmagina, Maksim Antonov, Aarne Kasikov, Olga Volobujeva, Eldar M Khabushev, Tanja Kallio, Sergei Bereznev

{"title":"Structural, Mechanical, and Optical Properties of Laminate-Type Thin Film SWCNT/SiOxNy Composites.","authors":"Elizaveta Shmagina, Maksim Antonov, Aarne Kasikov, Olga Volobujeva, Eldar M Khabushev, Tanja Kallio, Sergei Bereznev","doi":"10.3390/nano14221806","DOIUrl":"10.3390/nano14221806","url":null,"abstract":"The development of new encapsulating coatings for flexible solar cells (SCs) can help address the complex problem of the short lifespan of these devices, as well as optimize the technological process of their production. In this study, new laminate-type protective composite coatings were prepared using a silicon oxynitride thin-film matrix obtained by curing the pre-ceramic polymer perhydropolysilazane (PHPS) through two low-temperature methods: (i) thermal annealing at 180 °C and (ii) exposure to UV radiation at wavelengths of 185 and 254 nm. Single-walled carbon nanotubes (SWCNTs) were used as fillers via dry transfer, facilitating their horizontal orientation within the matrix. The optical, adhesive, and structural properties of the matrix films and SiOxNy/SWCNT composite coatings, along with their long-term stability, were studied using Fourier transform infrared spectroscopy (FTIR), UV-Vis spectroscopy, HR-SEM, spectral ellipsometry, and a progressive-load scratch test. In this work, the optical constants of PHPS-derived films were systematically studied for the first time. An antireflection effect was observed in the composites revealing their two-component nature associated with (i) the refractive index of the SiOxNy matrix film and (ii) the embedding of a SWCNT filler into the SiOxNy matrix. The curing method of PHPS was shown to significantly affect the resulting properties of the films. In addition to being used as protective multifunctional coatings for SCs, both SiOxNy/SWCNT composites and SiOxNy matrix films also function as broadband optical antireflective coatings. Furthermore, due to the very low friction coefficients observed in the mechanical tests, they show potential as scratch resistant coatings for mechanical applications.","PeriodicalId":18966,"journal":{"name":"Nanomaterials","volume":"14 22","pages":""},"PeriodicalIF":4.4,"publicationDate":"2024-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11597621/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142730860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gold Nanoparticles: Multifunctional Properties, Synthesis, and Future Prospects. 金纳米粒子：金纳米颗粒：多功能特性、合成与未来展望》。

IF 4.4 3区材料科学

Nanomaterials Pub Date : 2024-11-11 DOI: 10.3390/nano14221805

Hatice Duman, Emir Akdaşçi, Furkan Eker, Mikhael Bechelany, Sercan Karav

{"title":"Gold Nanoparticles: Multifunctional Properties, Synthesis, and Future Prospects.","authors":"Hatice Duman, Emir Akdaşçi, Furkan Eker, Mikhael Bechelany, Sercan Karav","doi":"10.3390/nano14221805","DOIUrl":"10.3390/nano14221805","url":null,"abstract":"Gold nanoparticles (NPs) are among the most commonly employed metal NPs in biological applications, with distinctive physicochemical features. Their extraordinary optical properties, stemming from strong localized surface plasmon resonance (LSPR), contribute to the development of novel approaches in the areas of bioimaging, biosensing, and cancer research, especially for photothermal and photodynamic therapy. The ease of functionalization with various ligands provides a novel approach to the precise delivery of these molecules to targeted areas. Gold NPs' ability to transfer heat and electricity positions them as valuable materials for advancing thermal management and electronic systems. Moreover, their inherent characteristics, such as inertness, give rise to the synthesis of novel antibacterial and antioxidant agents as they provide a biocompatible and low-toxicity approach. Chemical and physical synthesis methods are utilized to produce gold NPs. The pursuit of more ecologically sustainable and economically viable large-scale technologies, such as environmentally benign biological processes referred to as green/biological synthesis, has garnered increasing interest among global researchers. Green synthesis methods are more favorable than other synthesis techniques as they minimize the necessity for hazardous chemicals in the reduction process due to their simplicity, cost-effectiveness, energy efficiency, and biocompatibility. This article discusses the importance of gold NPs, their optical, conductivity, antibacterial, antioxidant, and anticancer properties, synthesis methods, contemporary uses, and biosafety, emphasizing the need to understand toxicology principles and green commercialization strategies.","PeriodicalId":18966,"journal":{"name":"Nanomaterials","volume":"14 22","pages":""},"PeriodicalIF":4.4,"publicationDate":"2024-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11597081/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142730859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Characterization of HZO Films Fabricated by Co-Plasma Atomic Layer Deposition for Ferroelectric Memory Applications. 用于铁电存储器应用的共等离子体原子层沉积制备的 HZO 薄膜的特性。

IF 4.4 3区材料科学

Nanomaterials Pub Date : 2024-11-10 DOI: 10.3390/nano14221801

Won-Ji Park, Ha-Jung Kim, Joung-Ho Lee, Jong-Hwan Kim, Sae-Hoon Uhm, So-Won Kim, Hee-Chul Lee

{"title":"Characterization of HZO Films Fabricated by Co-Plasma Atomic Layer Deposition for Ferroelectric Memory Applications.","authors":"Won-Ji Park, Ha-Jung Kim, Joung-Ho Lee, Jong-Hwan Kim, Sae-Hoon Uhm, So-Won Kim, Hee-Chul Lee","doi":"10.3390/nano14221801","DOIUrl":"10.3390/nano14221801","url":null,"abstract":"Plasma-enhanced atomic layer deposition (ALD) is a common method for fabricating Hf0.5Zr0.5O2 (HZO) ferroelectric thin films that can be performed using direct-plasma (DP) and remote-plasma (RP) methods. This study proposed co-plasma ALD (CPALD), where DPALD and RPALD are applied simultaneously. HZO films fabricated using this method showed wake-up-free polarization properties, no anti-ferroelectricity, and high fatigue endurance when DPALD and RPALD started simultaneously. To minimize defects in the film that could negatively affect the low polarization properties and fatigue endurance, the direct plasma power was reduced to 75 W. Thus, excellent fatigue endurance for at least 109 cycles was obtained under a high total remanent polarization of 47.3 μC/cm2 and an applied voltage of 2.5 V. X-ray photoelectron spectroscopy and transmission electron microscopy were used to investigate the mechanisms responsible for these properties. The HZO films fabricated by CPALD contained few lattice defects (such as nonstoichiometric hafnium, nonlattice oxygen, and residual carbon) and no paraelectric phase (m-phase). This was attributed to the low-carbon residuals in the film, as high-energy activated radicals were supplied by the adsorbed precursors during film formation. This facilitated a smooth transition to the o-phase during heat treatment, which possessed ferroelectric properties.","PeriodicalId":18966,"journal":{"name":"Nanomaterials","volume":"14 22","pages":""},"PeriodicalIF":4.4,"publicationDate":"2024-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11597536/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142730787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Harnessing a Safe Novel Lipid Nanoparticle: Targeted Oral Delivery to Colonic Epithelial and Macrophage Cells in a Colitis Mouse Model. 利用安全的新型脂质纳米粒子：在结肠炎小鼠模型中向结肠上皮细胞和巨噬细胞定向口服给药

IF 4.4 3区材料科学

Nanomaterials Pub Date : 2024-11-09 DOI: 10.3390/nano14221800

Rabeya Jafrin Mow, Michal Pawel Kuczma, Xiaodi Shi, Sridhar Mani, Didier Merlin, Chunhua Yang

{"title":"Harnessing a Safe Novel Lipid Nanoparticle: Targeted Oral Delivery to Colonic Epithelial and Macrophage Cells in a Colitis Mouse Model.","authors":"Rabeya Jafrin Mow, Michal Pawel Kuczma, Xiaodi Shi, Sridhar Mani, Didier Merlin, Chunhua Yang","doi":"10.3390/nano14221800","DOIUrl":"10.3390/nano14221800","url":null,"abstract":"A novel lipid nanoparticle (nLNP), formulated with three essential lipids to mimic ginger-derived exosomal particles, shows strong potential for delivering IL-22 mRNA specifically to the colon, presenting a unique oral drug delivery system for inflammatory bowel disease (IBD). However, its cellular targets and uptake behavior in healthy versus diseased colons remain unclear. Understanding these aspects is crucial for fully elucidating its targeting effectiveness in inflamed colon tissue. This study investigates the nLNP's cellular targets in healthy and diseased mouse colons. Flow cytometry compared nLNP uptake in healthy mice and a DSS-induced acute colitis model. The results revealed efficient internalization of nLNP by colonic epithelial cells in healthy and inflamed mice. In non-inflamed mice, the small number of colonic macrophages resulted in minimal uptake of nLNP by these cells. In inflamed mice, macrophages migrated to the damaged epithelium, where nLNP uptake was significantly increased, highlighting the nLNP's ability to target both epithelial and macrophage cells during inflammation. Additionally, safety assessments showed that the nLNP neither altered in vitro kinase activities nor exhibited immunotoxicity or induced in vivo toxicity at the maximum tolerated oral dose. These findings underscore the nLNP's safety and potential as a promising epithelial/macrophage-targeted drug delivery platform for oral ulcerative colitis (UC) treatment.","PeriodicalId":18966,"journal":{"name":"Nanomaterials","volume":"14 22","pages":""},"PeriodicalIF":4.4,"publicationDate":"2024-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11597058/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142730563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0