Nanomaterials最新文献

Flexible All-Carbon Nanoarchitecture Built from In Situ Formation of Nanoporous Graphene Within "Skeletal-Capillary" Carbon Nanotube Networks for Supercapacitors. 通过在 "骨架-毛细管 "碳纳米管网络中原位形成纳米多孔石墨烯构建柔性全碳纳米体系结构，用于超级电容器。

IF 4.4 3区材料科学

Nanomaterials Pub Date : 2024-10-21 DOI: 10.3390/nano14201683

Tao Chen, Hongyan Li, Jiaziyi Wang, Xilai Jia

引用次数: 0

Ligands of Nanoparticles and Their Influence on the Morphologies of Nanoparticle-Based Films. 纳米粒子配体及其对纳米粒子薄膜形态的影响。

IF 4.4 3区材料科学

Nanomaterials Pub Date : 2024-10-21 DOI: 10.3390/nano14201685

Jungwook Choi, Byung Hyo Kim

{"title":"Ligands of Nanoparticles and Their Influence on the Morphologies of Nanoparticle-Based Films.","authors":"Jungwook Choi, Byung Hyo Kim","doi":"10.3390/nano14201685","DOIUrl":"https://doi.org/10.3390/nano14201685","url":null,"abstract":"Nanoparticle-based thin films are increasingly being used in various applications. One of the key factors that determines the properties and performances of these films is the type of ligands attached to the nanoparticle surfaces. While long-chain surfactants, such as oleic acid, are commonly employed to stabilize nanoparticles and ensure high monodispersity, these ligands often hinder charge transport due to their insulating nature. Although thermal annealing can remove the long-chain ligands, the removal process often introduces defects such as cracks and voids. In contrast, the use of short-chain organic or inorganic ligands can minimize interparticle distance, improving film conductivity, though challenges such as incomplete ligand exchange and residual barriers remain. Polymeric ligands, especially block copolymers, can also be employed to create films with tailored porosity. This review discusses the effects of various ligand types on the morphology and performance of nanoparticle-based films, highlighting the trade-offs between conductivity, structural integrity, and functionality.","PeriodicalId":18966,"journal":{"name":"Nanomaterials","volume":null,"pages":null},"PeriodicalIF":4.4,"publicationDate":"2024-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11510505/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142504497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Phonon Drag Contribution to Thermopower for a Heated Metal Nanoisland on a Semiconductor Substrate. 半导体衬底上的受热金属纳米岛对热功率的声子拖曳贡献。

IF 4.4 3区材料科学

Nanomaterials Pub Date : 2024-10-21 DOI: 10.3390/nano14201684

Alexander Arkhipov, Karina Trofimovich, Nikolay Arkhipov, Pavel Gabdullin

{"title":"Phonon Drag Contribution to Thermopower for a Heated Metal Nanoisland on a Semiconductor Substrate.","authors":"Alexander Arkhipov, Karina Trofimovich, Nikolay Arkhipov, Pavel Gabdullin","doi":"10.3390/nano14201684","DOIUrl":"https://doi.org/10.3390/nano14201684","url":null,"abstract":"The possible contribution of phonon drag effect to the thermoelectrically sustained potential of a heated nanoisland on a semiconductor surface was estimated in a first principal consideration. We regarded electrons and phonons as interacting particles, and the interaction cross-section was derived from the basic theory of semiconductors. The solution of the equation of motion for average electrons under the simultaneous action of phonon drag and electric field gave the distributions of phonon flux, density of charge carriers and electric potential. Dimensional suppression of thermal conductance and electron-phonon interaction were accounted for but found to be less effective than expected. The developed model predicts the formation of a layer with a high density of charge carriers that is practically independent of the concentration of dopant ions. This layer can effectively intercept the phonon flow propagating from the heated nanoisland. The resulting thermoEMF can have sufficient magnitudes to explain the low-voltage electron emission capability of nanoisland films of metals and sp2-bonded carbon, previously studied by our group. The phenomenon predicted by the model can be used in thermoelectric converters with untypical parameters or in systems for local cooling.","PeriodicalId":18966,"journal":{"name":"Nanomaterials","volume":null,"pages":null},"PeriodicalIF":4.4,"publicationDate":"2024-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11509935/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142504509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enhancing Charge Trapping Performance of Hafnia Thin Films Using Sequential Plasma Atomic Layer Deposition. 利用序贯等离子体原子层沉积提高哈夫纳薄膜的电荷捕获性能。

IF 4.4 3区材料科学

Nanomaterials Pub Date : 2024-10-21 DOI: 10.3390/nano14201686

So-Won Kim, Jae-Hoon Yoo, Won-Ji Park, Chan-Hee Lee, Joung-Ho Lee, Jong-Hwan Kim, Sae-Hoon Uhm, Hee-Chul Lee

{"title":"Enhancing Charge Trapping Performance of Hafnia Thin Films Using Sequential Plasma Atomic Layer Deposition.","authors":"So-Won Kim, Jae-Hoon Yoo, Won-Ji Park, Chan-Hee Lee, Joung-Ho Lee, Jong-Hwan Kim, Sae-Hoon Uhm, Hee-Chul Lee","doi":"10.3390/nano14201686","DOIUrl":"https://doi.org/10.3390/nano14201686","url":null,"abstract":"We aimed to fabricate reliable memory devices using HfO2, which is gaining attention as a charge-trapping layer material for next-generation NAND flash memory. To this end, a new atomic layer deposition process using sequential remote plasma (RP) and direct plasma (DP) was designed to create charge-trapping memory devices. Subsequently, the operational characteristics of the devices were analyzed based on the thickness ratio of thin films deposited using the sequential RP and DP processes. As the thickness of the initially RP-deposited thin film increased, the memory window and retention also increased, while the interface defect density and leakage current decreased. When the thickness of the RP-deposited thin film was 7 nm, a maximum memory window of 10.1 V was achieved at an operating voltage of ±10 V, and the interface trap density (Dit) reached a minimum value of 1.0 × 1012 eV-1cm-2. Once the RP-deposited thin film reaches a certain thickness, the ion bombardment effect from DP on the substrate is expected to decrease, improving the Si/SiO2/HfO2 interface and thereby enhancing device endurance and reliability. This study confirmed that the proposed sequential RP and DP deposition processes could resolve issues related to unstable interface layers, improve device performance, and enhance process throughput.","PeriodicalId":18966,"journal":{"name":"Nanomaterials","volume":null,"pages":null},"PeriodicalIF":4.4,"publicationDate":"2024-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11509989/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142504484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

On the Synthesis of Graphene Oxide/Titanium Dioxide (GO/TiO₂) Nanorods and Their Application as Saturable Absorbers for Passive Q-Switched Fiber Lasers. 氧化石墨烯/二氧化钛（GO/TiO2）纳米棒的合成及其作为无源 Q 开关光纤激光器饱和吸收体的应用。

IF 4.4 3区材料科学

Nanomaterials Pub Date : 2024-10-20 DOI: 10.3390/nano14201682

Zain Ul Abedin, Ajaz Ul Haq, Rizwan Ahmed, Tahani A Alrebdi, Ali M Alshehri, Muhammad Irfan, Haroon Asghar

{"title":"On the Synthesis of Graphene Oxide/Titanium Dioxide (GO/TiO2) Nanorods and Their Application as Saturable Absorbers for Passive Q-Switched Fiber Lasers.","authors":"Zain Ul Abedin, Ajaz Ul Haq, Rizwan Ahmed, Tahani A Alrebdi, Ali M Alshehri, Muhammad Irfan, Haroon Asghar","doi":"10.3390/nano14201682","DOIUrl":"https://doi.org/10.3390/nano14201682","url":null,"abstract":"We report passively Q-switched pulse operation through an erbium-doped fiber laser (EDFL) utilizing graphene oxide/titania (GO/TiO2) nanorods as a saturable absorber. The GO/TiO2 nanorods were fabricated using a Sol-gel-assisted hydrothermal method. The optical and physical characterization of the GO/TiO2 was then characterized using a field-emission-scanning electron microscope (FE-SEM), energy-dispersive X-ray spectroscopy (EDS), and diffuses reflectance spectroscopy (DRS). To investigate the performance of the Q-switched EDFL based on the GO/TiO2 SA, the prepared nanorods were mechanically deposited on the fiber ferrule employing adhesion effects of in-dex-matching gel. This integration of the nanorod SA resulted in a self-starting Q-switching opera-tion initiated at a pump power of 17.5 mW and sustained up to 306.9 mW. When the pump range was tuned from 17.5 to 306.9 mW, the emission wavelength varied from 1564.2 to 1562.9 nm, pulse repetition rates increased from 13.87 kHz to 83.33 kHz, and pulse width decreased from 30.27 µs to 3.75 µs. Moreover, at the maximum pump power of 306.9 mW, the laser exhibited an average output power of 0.74 mW, a peak power of 1.54 mW, and a pulse energy of 8.88 nJ. Furthermore, this study investigates the GO/TiO2 damage threshold and prolonged stability of the proposed EDFL system.","PeriodicalId":18966,"journal":{"name":"Nanomaterials","volume":null,"pages":null},"PeriodicalIF":4.4,"publicationDate":"2024-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11510206/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142504505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Silver-Doped Reduced Graphene Oxide/PANI-DBSA-PLA Composite 3D-Printed Supercapacitors. 掺银还原氧化石墨烯/PANI-DBSA-PLA 复合材料三维打印超级电容器。

IF 4.4 3区材料科学

Nanomaterials Pub Date : 2024-10-20 DOI: 10.3390/nano14201681

Claudia Cirillo, Mariagrazia Iuliano, Davide Scarpa, Pierpaolo Iovane, Carmela Borriello, Sabrina Portofino, Sergio Galvagno, Maria Sarno

{"title":"Silver-Doped Reduced Graphene Oxide/PANI-DBSA-PLA Composite 3D-Printed Supercapacitors.","authors":"Claudia Cirillo, Mariagrazia Iuliano, Davide Scarpa, Pierpaolo Iovane, Carmela Borriello, Sabrina Portofino, Sergio Galvagno, Maria Sarno","doi":"10.3390/nano14201681","DOIUrl":"10.3390/nano14201681","url":null,"abstract":"This study presents a novel approach to the development of high-performance supercapacitors through 3D printing technology. We synthesized a composite material consisting of silver-doped reduced graphene oxide (rGO) and dodecylbenzenesulfonic acid (DBSA)-doped polyaniline (PANI), which was further blended with polylactic acid (PLA) for additive manufacturing. The composite was extruded into filaments and printed into circular disc electrodes using fused deposition modeling (FDM). These electrodes were assembled into symmetric supercapacitor devices with a solid-state electrolyte. Electrochemical characterization, including cyclic voltammetry (CV) and galvanostatic charge-discharge (GCD) tests, demonstrated considerable mass-specific capacitance values of 136.2 F/g and 133 F/g at 20 mV/s and 1 A/g, respectively. The devices showed excellent stability, retaining 91% of their initial capacitance after 5000 cycles. The incorporation of silver nanoparticles enhanced the conductivity of rGO, while PANI-DBSA improved electrochemical stability and performance. This study highlights the potential of combining advanced materials with 3D printing to optimize energy storage devices, offering a significant advancement over traditional manufacturing methods.","PeriodicalId":18966,"journal":{"name":"Nanomaterials","volume":null,"pages":null},"PeriodicalIF":4.4,"publicationDate":"2024-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11514729/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142504515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Toxicological Characteristics of Bacterial Nanocellulose in an In Vivo Experiment-Part 2: Immunological Endpoints, Influence on the Intestinal Barrier and Microbiome. 体内实验中细菌纳米纤维素的毒理学特征--第 2 部分：免疫学终点、对肠道屏障和微生物组的影响。

IF 4.4 3区材料科学

Nanomaterials Pub Date : 2024-10-19 DOI: 10.3390/nano14201678

Vladimir A Shipelin, Ekaterina A Skiba, Vera V Budaeva, Antonina A Shumakova, Eleonora N Trushina, Oksana K Mustafina, Yuliya M Markova, Nikolay A Riger, Ivan V Gmoshinski, Svetlana A Sheveleva, Sergey A Khotimchenko, Dmitry B Nikityuk

{"title":"Toxicological Characteristics of Bacterial Nanocellulose in an In Vivo Experiment-Part 2: Immunological Endpoints, Influence on the Intestinal Barrier and Microbiome.","authors":"Vladimir A Shipelin, Ekaterina A Skiba, Vera V Budaeva, Antonina A Shumakova, Eleonora N Trushina, Oksana K Mustafina, Yuliya M Markova, Nikolay A Riger, Ivan V Gmoshinski, Svetlana A Sheveleva, Sergey A Khotimchenko, Dmitry B Nikityuk","doi":"10.3390/nano14201678","DOIUrl":"https://doi.org/10.3390/nano14201678","url":null,"abstract":"Bacterial nanocellulose (BNC) is considered a promising alternative to microcrystalline cellulose, as well as an ingredient in low-calorie dietary products. However, the risks of BNC when consumed with food are not well characterized. The aim of this study is to investigate the impact of BNC on immune function, the intestinal microbiome, intestinal barrier integrity, and allergic sensitization in subacute experiments on rats. Male Wistar rats received BNC with a diet for eight weeks in a dose range of 1-100 mg/kg of body weight. The measurements of serum levels of cytokines, adipokines, iFABP2, indicators of cellular immunity, composition of the intestinal microbiome, and a histological study of the ileal mucosa were performed. In a separate four-week experiment on a model of systemic anaphylaxis to food antigen, BNC at a dose of 100 mg/kg of body weight did not increase the severity of the reaction or change the response of IgG antibodies. Based on dose-response effects on immune function, the non-observed adverse effect level for BNC was less than 100 mg/kg of body weight per day. The effects of BNC on the gut microbiome and the intestinal mucosal barrier were not dose-dependent. Data on the possible presence of prebiotic effects in BNC have been obtained.","PeriodicalId":18966,"journal":{"name":"Nanomaterials","volume":null,"pages":null},"PeriodicalIF":4.4,"publicationDate":"2024-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11510458/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142504524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Printability Metrics and Engineering Response of HDPE/Si₃N₄ Nanocomposites in MEX Additive Manufacturing. 高密度聚乙烯/Si3N4 纳米复合材料在 MEX 增材制造中的可印刷性指标和工程响应。

IF 4.4 3区材料科学

Nanomaterials Pub Date : 2024-10-19 DOI: 10.3390/nano14201680

Vassilis M Papadakis, Markos Petousis, Nikolaos Michailidis, Maria Spyridaki, Ioannis Valsamos, Apostolos Argyros, Katerina Gkagkanatsiou, Amalia Moutsopoulou, Nectarios Vidakis

{"title":"Printability Metrics and Engineering Response of HDPE/Si3N4 Nanocomposites in MEX Additive Manufacturing.","authors":"Vassilis M Papadakis, Markos Petousis, Nikolaos Michailidis, Maria Spyridaki, Ioannis Valsamos, Apostolos Argyros, Katerina Gkagkanatsiou, Amalia Moutsopoulou, Nectarios Vidakis","doi":"10.3390/nano14201680","DOIUrl":"https://doi.org/10.3390/nano14201680","url":null,"abstract":"Herein, silicon nitride (Si3N4) was the selected additive to be examined for its reinforcing properties on high-density polyethylene (HDPE) by exploiting techniques of the popular material extrusion (MEX) 3D printing method. Six different HDPE/Si3N4 composites with filler percentages ranging between 0.0-10.0 wt. %, having a 2.0 step, were produced initially in compounds, then in filaments, and later in the form of specimens, to be examined by a series of tests. Thermal, rheological, mechanical, structural, and morphological analyses were also performed. For comprehensive mechanical characterization, tensile, flexural, microhardness (M-H), and Charpy impacts were included. Scanning electron microscopy (SME) was used for morphological assessments and microcomputed tomography (μ-CT). Raman spectroscopy was conducted, and the elemental composition was assessed using energy-dispersive spectroscopy (EDS). The HDPE/Si3N4 composite with 6.0 wt. % was the one with an enhancing performance higher than the rest of the composites, in the majority of the mechanical metrics (more than 20% in the tensile and flexural experiment), showing a strong potential for Si3N4 as a reinforcement additive in 3D printing. This method can be easily industrialized by further exploiting the MEX 3D printing method.","PeriodicalId":18966,"journal":{"name":"Nanomaterials","volume":null,"pages":null},"PeriodicalIF":4.4,"publicationDate":"2024-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11510129/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142504510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Review of Wide Bandgap Semiconductors: Insights into SiC, IGZO, and Their Defect Characteristics. 宽带隙半导体综述：深入了解碳化硅、IGZO 及其缺陷特性。

IF 4.4 3区材料科学

Nanomaterials Pub Date : 2024-10-19 DOI: 10.3390/nano14201679

Qiwei Shangguan, Yawei Lv, Changzhong Jiang

{"title":"A Review of Wide Bandgap Semiconductors: Insights into SiC, IGZO, and Their Defect Characteristics.","authors":"Qiwei Shangguan, Yawei Lv, Changzhong Jiang","doi":"10.3390/nano14201679","DOIUrl":"https://doi.org/10.3390/nano14201679","url":null,"abstract":"Although the irreplaceable position of silicon (Si) semiconductor materials in the field of information has become a consensus, new materials continue to be sought to expand the application range of semiconductor devices. Among them, research on wide bandgap semiconductors has already achieved preliminary success, and the relevant achievements have been applied in the fields of energy conversion, display, and storage. However, similar to the history of Si, the immature material grown and device manufacturing processes at the current stage seriously hinder the popularization of wide bandgap semiconductor-based applications, and one of the crucial issues behind this is the defect problem. Here, we take amorphous indium gallium zinc oxide (a-IGZO) and 4H silicon carbide (4H-SiC) as two representatives to discuss physical/mechanical properties, electrical performance, and stability from the perspective of defects. Relevant experimental and theoretical works on defect formation, evolution, and annihilation are summarized, and the impacts on carrier transport behaviors are highlighted. State-of-the-art applications using the two materials are also briefly reviewed. This review aims to assist researchers in elucidating the complex impacts of defects on electrical behaviors of wide bandgap semiconductors, enabling them to make judgments on potential defect issues that may arise in their own processes. It aims to contribute to the effort of using various post-treatment methods to control defect behaviors and achieve the desired material and device performance.","PeriodicalId":18966,"journal":{"name":"Nanomaterials","volume":null,"pages":null},"PeriodicalIF":4.4,"publicationDate":"2024-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11510050/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142504372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

T1/T2 Proportional Magnetic Resonance Nanoprobe Monitoring Tumor Autophagy during Chemotherapy. T1/T2 比例磁共振纳米探针在化疗期间监测肿瘤自噬过程

IF 4.4 3区材料科学

Nanomaterials Pub Date : 2024-10-18 DOI: 10.3390/nano14201673

Jia Cui, Taixing Zhang, Fei Wang, Lingzi Feng, Guangjun Deng, Ting Wu, Le Yin, Yong Hu

{"title":"T1/T2 Proportional Magnetic Resonance Nanoprobe Monitoring Tumor Autophagy during Chemotherapy.","authors":"Jia Cui, Taixing Zhang, Fei Wang, Lingzi Feng, Guangjun Deng, Ting Wu, Le Yin, Yong Hu","doi":"10.3390/nano14201673","DOIUrl":"https://doi.org/10.3390/nano14201673","url":null,"abstract":"Autophagy leads to cellular tolerance of the therapeutic pressure of chemotherapeutic drugs, resulting in treatment resistance. Therefore, the effective monitoring of the autophagy status of tumors in vivo and the regulating of the autophagy level are crucial for improving the efficacy of chemotherapy. In this work, we grafted nitroxide radicals onto the surface of iron oxide nanoparticles (Fe3O4 NPs) using dendrimer polymers, yielding Fe3O4-NO· NPs that are responsive to reactive oxygen species (ROS) and possess enhanced T1 and T2 signal capabilities in a magnetic resonance imaging (MRI) measurement. The ROS in tumor cells generated by autophagy quenches the nitroxide radicals, thereby weakening the T1 signal. In contrast, Fe3O4 NPs are unaffected by intracellular ROS, leading to a stable T2 signal. By comparing the intensity ratio of T1 to T2 in Fe3O4-NO· NPs, we can evaluate the in vivo autophagy status within tumors in real time. It also revealed that Fe3O4-NO· NPs loaded with doxorubicin (Dox) and combining the autophagy inhibitor exhibited high antitumor activity in cells and tumor-bearing mice. This system, which combines real-time monitoring of tumor cell autophagy with the delivery of chemotherapeutic drugs, provides an innovative and effective strategy for tumor treatment with potential clinical application prospects.","PeriodicalId":18966,"journal":{"name":"Nanomaterials","volume":null,"pages":null},"PeriodicalIF":4.4,"publicationDate":"2024-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11510095/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142504519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0