Journal of Veterinary Science最新文献_第5页

Prevalence and molecular characteristics of carbapenem-resistant Escherichia coli isolated from dogs in South Korea. 从韩国狗体内分离的耐碳青霉烯类大肠埃希菌的流行率和分子特征。

IF 1.5 3区农林科学

Journal of Veterinary Science Pub Date : 2024-09-01 DOI: 10.4142/jvs.24164

Bo-Youn Moon, Md Sekendar Ali, Seunghoe Kim, Hee-Seung Kang, Ye-Ji Kang, Jae-Myung Kim, Dong-Chan Moon, Suk-Kyung Lim

{"title":"Prevalence and molecular characteristics of carbapenem-resistant Escherichia coli isolated from dogs in South Korea.","authors":"Bo-Youn Moon, Md Sekendar Ali, Seunghoe Kim, Hee-Seung Kang, Ye-Ji Kang, Jae-Myung Kim, Dong-Chan Moon, Suk-Kyung Lim","doi":"10.4142/jvs.24164","DOIUrl":"10.4142/jvs.24164","url":null,"abstract":"Importance: Carbapenem-resistant Enterobacteriaceae are emerging as a global public health risk. Therefore, assessing the prevalence of carbapenem-resistant Escherichia coli (CRE) in both humans and animals is important.Objective: We aimed to ascertain the occurrence and characteristics of CRE isolated from companion animals, dogs and cats.Methods: E. coli strains were tested for antimicrobial susceptibility using the broth microdilution technique. Antimicrobial resistance genes were detected by polymerase chain reaction and sequencing analysis. The molecular characteristics of CRE were determined using multi-locus sequence typing, replicon typing, and pulsed-field gel electrophoresis (PFGE).Results: In total, 13 CRE isolates (0.13%) were identified from dogs possessing blaNDM-5 along with β-lactamase genes, mostly blaCMY-2 (92.2%) and blaTEM-1 (53.8%). The commonly observed mutations were S83L and D87N in gyrA, S80I in parC, and S458A in parE. CRE carried non-beta-lactam resistance genes, with the majority being tet(B) (100%), sul (84.6%), and aac(3)-II (53.8%). Nine different PFGE patterns (P1-P9), IncX3-type plasmids (69.2%), and ST410 (84.6%) were predominantly detected.Conclusions and relevance: This investigation provides significant insight into the prevalence and molecular characteristics of blaNDM-5-carrying E. coli in dogs. The co-existence of blaNDM-5 and other antimicrobial resistance genes in E. coli potentially poses severe health hazards to humans.","PeriodicalId":17557,"journal":{"name":"Journal of Veterinary Science","volume":"25 5","pages":"e67"},"PeriodicalIF":1.5,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11450394/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142372216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Different development patterns of reward behaviors induced by ketamine and JWH-018 in striatal GAD67 knockdown mice. 氯胺酮和JWH-018诱导纹状体GAD67基因敲除小鼠奖赏行为的不同发展模式

IF 1.5 3区农林科学

Journal of Veterinary Science Pub Date : 2024-09-01 Epub Date: 2024-08-12 DOI: 10.4142/jvs.23325

Sun Mi Gu, Eunchong Hong, Sowoon Seo, Sanghyeon Kim, Seong Shoon Yoon, Hye Jin Cha, Jaesuk Yun

{"title":"Different development patterns of reward behaviors induced by ketamine and JWH-018 in striatal GAD67 knockdown mice.","authors":"Sun Mi Gu, Eunchong Hong, Sowoon Seo, Sanghyeon Kim, Seong Shoon Yoon, Hye Jin Cha, Jaesuk Yun","doi":"10.4142/jvs.23325","DOIUrl":"10.4142/jvs.23325","url":null,"abstract":"Importance: Glutamic acid decarboxylase 67 (GAD67) is a gamma-aminobutyric acid (GABA) synthesis enzyme associated with the function of other neurotransmitter receptors, such as the N-methyl-D-aspartate (NMDA) receptor and cannabinoid receptor 1. However, the role of GAD67 in the development of different abused drug-induced reward behaviors remains unknown. In order to elucidate the mechanisms of substance use disorder, it is crucial to study changes in biomarkers within the brain's reward circuit induced by drug use.Objective: The study was designed to examine the effects of the downregulation of GAD67 expression in the dorsal striatum on reward behavior development.Methods: We evaluated the effects of GAD67 knockdown on depression-like behavior and anxiety using the forced swim test and elevated plus maze test in a mouse model. We further determined the effects of GAD67 knockdown on ketamine- and JWH-018-induced conditioned place preference (CPP).Results: Knockdown of GAD67 in the dorsal striatum of mice increased depression-like behavior, but it decreased anxiety. Moreover, the CPP score on the NMDA receptor antagonist ketamine was increased by GAD67 knockdown, whereas the administration of JWH-018, a cannabinoid receptor agonist, did not affect the CPP score in the GAD67 knockdown mice group compared with the control group.Conclusions and relevance: These results suggest that striatal GAD67 reduces GABAergic neuronal activity and may cause ketamine-induced NMDA receptor inhibition. Consequently, GAD67 downregulation induces vulnerability to the drug reward behavior of ketamine.","PeriodicalId":17557,"journal":{"name":"Journal of Veterinary Science","volume":" ","pages":"e63"},"PeriodicalIF":1.5,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11450393/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142133090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Meat ducks as carriers of antimicrobial-resistant Escherichia coli harboring transferable R plasmids. 肉鸭是携带可转移 R 质粒的耐抗菌大肠杆菌的载体。

IF 1.5 3区农林科学

Journal of Veterinary Science Pub Date : 2024-09-01 Epub Date: 2024-08-12 DOI: 10.4142/jvs.24074

Zulqarnain Baqar, Nuananong Sinwat, Rangsiya Prathan, Rungtip Chuanchuen

{"title":"Meat ducks as carriers of antimicrobial-resistant Escherichia coli harboring transferable R plasmids.","authors":"Zulqarnain Baqar, Nuananong Sinwat, Rangsiya Prathan, Rungtip Chuanchuen","doi":"10.4142/jvs.24074","DOIUrl":"10.4142/jvs.24074","url":null,"abstract":"Importance: Antimicrobial resistance (AMR) is a serious public health threat. AMR bacteria and their resistance determinants in food can be transmitted to humans through the food chain and by direct contact and disseminate directly to the environment.Objective: This study examined the AMR characteristics and transferable R plasmids in Escherichia coli isolated from meat ducks raised in an open-house system.Methods: One hundred seventy-seven (n = 177) commensal E. coli were examined for their antimicrobial susceptibilities and horizontal resistance transfer. The plasmids were examined by PCR-based plasmid replicon typing (PBRT) and plasmid multi-locus sequence typing (pMLST).Results: The highest resistance rate was found against ampicillin (AMP, 83.0%) and tetracycline (TET, 81.9%), and most isolates exhibited multidrug resistance (MDR) (86.4%). The R plasmids were conjugally transferred when TET (n = 4), AMP (n = 3), and chloramphenicol (n = 3) were used as a selective pressure. The three isolates transferred resistance genes either in AMP or TET. The blaCTX-M1 gene resided on conjugative plasmids. Five replicon types were identified, of which Inc FrepB was most common in the donors (n = 13, 38.4%) and transconjugants (n = 16, 31.2%). Subtyping F plasmids revealed five distinct replicons combinations, including F47:A-:B- (n = 2), F29:A-:B23 (n = 1), F29:A-:B- (n = 1), F18:A-B:- (n = 1), and F4:A-:B- (n = 1). The chloramphenicol resistance was significantly correlated with the other AMR phenotypes (p < 0.05).Conclusions and relevance: The meat ducks harbored MDR E. coli and played an important role in the environmental dissemination of AMR bacteria and its determinants. This confirms AMR as a health issue, highlighting the need for routine AMR monitoring and surveillance of meat ducks.","PeriodicalId":17557,"journal":{"name":"Journal of Veterinary Science","volume":" ","pages":"e62"},"PeriodicalIF":1.5,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11450392/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142133093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Oxidative hemolytic crises in a dog due to fragrance products: clinical insights and treatment approaches. 香料产品导致的犬氧化性溶血危机：临床见解和治疗方法。

IF 1.5 3区农林科学

Journal of Veterinary Science Pub Date : 2024-09-01 Epub Date: 2024-08-14 DOI: 10.4142/jvs.24160

Sully Lee, Kyoung-Won Seo, Urs Giger, Min-Ok Ryu

{"title":"Oxidative hemolytic crises in a dog due to fragrance products: clinical insights and treatment approaches.","authors":"Sully Lee, Kyoung-Won Seo, Urs Giger, Min-Ok Ryu","doi":"10.4142/jvs.24160","DOIUrl":"10.4142/jvs.24160","url":null,"abstract":"Importance: This is the first reported case of fragrance products-induced recurrent oxidative hemolytic anemia in a dog, detailing the successful therapeutic approach employed.Case presentation: A 4-year-old intact female Pomeranian dog presented with brown tongue, pigmenturia, peripheral edema, and vomiting. Blood smears revealed a high count of eccentrocytes and Heinz bodies, along with a precipitous decline in packed cell volume and an increase in blood methemoglobin levels, suggesting an oxidative hemolytic crisis. This clinicopathological pattern recurred several times after the patient returned home. Antioxidants, methylene blue, hyperbaric oxygen (HBO) therapy, and blood transfusion were successfully employed to address recurrent hemolytic anemia; however, oxidative hemolytic crises recurred. After the owner removed exposure to various home remedies and fragrances, the clinical signs and hemolytic crises did not recur.Conclusions and relevance: Recurring oxidative hemolytic crises should raise suspicions of environmental toxicity, which, although harmless in small quantities to humans, can be devastating to small-breed dogs. In addition to removing the causative agents, methylene blue and other antioxidants, along with HBO, may be beneficial in the acute management of oxidative hemolytic anemia.","PeriodicalId":17557,"journal":{"name":"Journal of Veterinary Science","volume":" ","pages":"e64"},"PeriodicalIF":1.5,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11450391/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142133094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Immuno-protective effect of commercial IBD vaccines against emerging novel variant infectious bursal disease virus in specific-pathogen-free chickens. 商用法氏囊病疫苗对新出现的新型变异传染性法氏囊病病毒的免疫保护作用。

IF 1.5 3区农林科学

Journal of Veterinary Science Pub Date : 2024-09-01 DOI: 10.4142/jvs.23297

Hayatuddeen Bako Aliyu, Tasiu Mallam Hamisu, Mohd Hair-Bejo, Abdul Rahman Omar, Aini Ideris

{"title":"Immuno-protective effect of commercial IBD vaccines against emerging novel variant infectious bursal disease virus in specific-pathogen-free chickens.","authors":"Hayatuddeen Bako Aliyu, Tasiu Mallam Hamisu, Mohd Hair-Bejo, Abdul Rahman Omar, Aini Ideris","doi":"10.4142/jvs.23297","DOIUrl":"10.4142/jvs.23297","url":null,"abstract":"Importance: Infectious bursal disease (IBD) is an important viral poultry disease that vaccination can control.Objective: This study examined the immune protection of immune-complex (Vaccine A) and attenuated live (Vaccine B) IBD vaccines in specific-pathogen-free (SPF) chickens against a novel Malaysian variant IBD virus (vaIBDV) challenge.Methods: One-day-old (n =75) SPF chickens were divided randomly into the following three groups of 25 chicks each: Control, Vaccine A, and Vaccine B groups. The vaIBDV strain, UPM1432/2019, was used for the challenge at 21 and 28days post-vaccination (dpv). Five birds from unchallenged and challenged groups were sacrificed seven days post-challenge, and blood, bursa, spleen, and cloacal swabs were collected. The IBD antibodies (Abs), lymphoid lesions, and viral load were determined.Results: The UPM1432/2019 virus induced bursal damage in vaccinated SPF chickens despite Ab titers. The mean Ab titers of the Vaccine A challenged group were significantly lower (p < 0.002) than in the unchallenged group at 28 dpv. The bursal indices of the vaccinated unchallenged groups did not differ significantly from those of the vaccinated challenged groups (p = 0.94). Microscopically, the bursae of the challenged groups showed significant atrophy. The bursal lesion score was higher (p < 0.05) in the control and Vaccine B challenged groups than the Vaccine A challenged group. The challenged group had a higher viral load than the vaccinated groups (p < 0.001).Conclusions and relevance: Neither vaccine fully protected against a vaIBDV challenge, highlighting the limitations of current vaccines and the need for further research.","PeriodicalId":17557,"journal":{"name":"Journal of Veterinary Science","volume":"25 5","pages":"e70"},"PeriodicalIF":1.5,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11450385/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142372212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Molecular characteristics and antimicrobial susceptibility profiles of bovine mastitis agents in western Türkiye. 图尔基耶西部牛乳腺炎病原体的分子特征和抗菌药敏感性概况。

IF 1.5 3区农林科学

Journal of Veterinary Science Pub Date : 2024-09-01 DOI: 10.4142/jvs.24032

Semiha Yalcin, Arzu Ozgen, Metehan Simsir

{"title":"Molecular characteristics and antimicrobial susceptibility profiles of bovine mastitis agents in western Türkiye.","authors":"Semiha Yalcin, Arzu Ozgen, Metehan Simsir","doi":"10.4142/jvs.24032","DOIUrl":"10.4142/jvs.24032","url":null,"abstract":"Importance: Identifying bovine mastitis agents using molecular methods to reveal their phylogenetic relationships and antimicrobial resistance profiles is essential for developing up-to-date databases in mastitis cases that cause severe economic losses.Objective: This study examined bacterial mastitis agents in cows with clinical and subclinical mastitis observed in various dairy cattle farms to reveal their phylogenetic relationships and antibiotic resistance properties.Methods: Sixty-two clinical and subclinical bovine mastitis milk samples were collected from 15 dairy farms. The polymerase chain reaction (PCR) was used to amplify the 16S rRNA gene regions of the bacteria. The 16S rRNA gene sequences obtained from sequencing include the V4-V6 regions. The strains were compared using a similarity analysis method that produced phylogenetic trees using the Molecular Evolutionary Genetics Analysis 11 program. Antibiotic susceptibilities were determined using the Kirby-Bauer disk diffusion method.Results: Sixty-three bacteria were isolated and identified in this study. The most isolated bacteria from all mastitis cases were Staphylococcus spp. (30.2%), Escherichia coli (25.4%), Streptococcus spp. (14.3%), and Aerococcus spp. (7.9%), respectively. The phylogenetic trees were drawn from the 16S rRNA sequences. Some of these bacteria showed resistance to different types of antibiotics at varying rates.Conclusions and relevance: The bacteria isolated in this study originated from environmental sources. Regular cleaning of barns and proper hygiene practices are essential. Regular screenings for mastitis should be conducted in herds instead of the random or empirical use of antibiotics.","PeriodicalId":17557,"journal":{"name":"Journal of Veterinary Science","volume":"25 5","pages":"e72"},"PeriodicalIF":1.5,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11450396/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142372215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Developing veterinary basic clinical skill items based on Korean Veterinary Entrustable Professional Activity. 根据韩国兽医委托专业活动开发兽医基本临床技能项目。

IF 1.5 3区农林科学

Journal of Veterinary Science Pub Date : 2024-09-01 DOI: 10.4142/jvs.24129

Kichang Lee, Heungshik S Lee, Seong Mok Jeong, Jongil Kang, Seungjoon Kim, Jin-Young Chung, Sang-Soep Nahm, Pan Dong Ryu

{"title":"Developing veterinary basic clinical skill items based on Korean Veterinary Entrustable Professional Activity.","authors":"Kichang Lee, Heungshik S Lee, Seong Mok Jeong, Jongil Kang, Seungjoon Kim, Jin-Young Chung, Sang-Soep Nahm, Pan Dong Ryu","doi":"10.4142/jvs.24129","DOIUrl":"10.4142/jvs.24129","url":null,"abstract":"Importance: Developing clinical skills is an essential element of veterinary education to ensure the competency of veterinary graduates. Although the Korean Veterinary Education Graduation Competencies were established in 2016, reflecting domestic needs and international trends in competency-based veterinary education, they have yet to be implemented in Korean veterinary education.Objective: This study aimed to establish the basic veterinary clinical skills required to ensure graduates of Korean veterinary universities have the day-one competency to independently perform their professional duties.Methods: The Education Committee of the Korean Association of Veterinary Medical Colleges, composed of veterinary school professors and an experienced veterinarian in the clinic, reviewed domestic and international veterinary education-related materials to define basic clinical skills.Results: The Korean Veterinarian Entrustable Professional Activities (KVEPA) was introduced, followed by the subsequent development of 54 essential clinical skills based on the KVEPA.Conclusions and relevance: The veterinary basic clinical skills established through this study can be used as a specific guide for clinical education in Korean veterinary school, and is expected to play an important role in meeting the needs of the educational sector of the veterinary education accreditation standards.","PeriodicalId":17557,"journal":{"name":"Journal of Veterinary Science","volume":"25 5","pages":"e71"},"PeriodicalIF":1.5,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11450386/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142372211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Identification of concurrent infection with Jaagsiekte sheep retrovirus and maedi-visna virus in China. 确定中国同时感染了Jaagsiekte羊逆转录病毒和maedi-visna病毒。

IF 1.5 3区农林科学

Journal of Veterinary Science Pub Date : 2024-09-01 Epub Date: 2024-08-08 DOI: 10.4142/jvs.24158

Xujie Duan, Xiaona Shi, Pei Zhang, Xiaoyue Du, Sixu Chen, Liang Zhang, Huiping Li, Yufei Zhang, Jinling Wang, Yulin Ding, Shuying Liu

{"title":"Identification of concurrent infection with Jaagsiekte sheep retrovirus and maedi-visna virus in China.","authors":"Xujie Duan, Xiaona Shi, Pei Zhang, Xiaoyue Du, Sixu Chen, Liang Zhang, Huiping Li, Yufei Zhang, Jinling Wang, Yulin Ding, Shuying Liu","doi":"10.4142/jvs.24158","DOIUrl":"10.4142/jvs.24158","url":null,"abstract":"Importance: Ovine pulmonary adenomatosis (OPA) and maedi-visna disease (MVD) are chronic and progressive infectious diseases in sheep caused by Jaagsiekte sheep retrovirus (JSRV) and maedi-visna virus (MVV), respectively.Objective: To investigate the pathological changes and conduct viral gene analysis of OPA and MVD co-occurrence in Inner Mongolia, China.Methods: Using gross pathology, histopathology, immunohistochemistry, ultrastructural pathology, PCR, and sequence analysis, we investigated the concurrent infection of JSRV and MVV in 319 Dorper rams slaughtered in a private slaughterhouse in Inner Mongolia, in 2022.Results: Of the 319 rams included, 3 showed concurrent JSRV and MVV infection. Gross lung pathology showed diffuse enlargement, consolidation, and greyish-white miliary nodules on the lung surface; the trachea was filled with a white foamy fluid; hilar and mediastinal lymph nodes were significantly enlarged. Histopathology results revealed typical OPA and MVD lesions in the lung tissue. Immunohistochemical results were positive for JSRV envelope protein (Env) in the tumor cells and MVV CA in alveolar macrophages. Transmission electron microscopy showed several virions and autophagosomes in the lung tissue, severely damaged mitochondria, and the induced mitophagy. Nucleotide sequences obtained for JSRV env and MVV gag showed the highest homology with the Inner Mongolian strains of JSRV env (JQ837489) and MVV gag (MW248464).Conclusions and relevance: Our study confirmed that OPA and MVD co-occurrence and identified the pathological changes in Inner Mongolia, China, thereby providing references for the identification of concurrent JSRV and MVV infections.","PeriodicalId":17557,"journal":{"name":"Journal of Veterinary Science","volume":" ","pages":"e61"},"PeriodicalIF":1.5,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11450398/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142133092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Identification of a new bovine picornavirus (Boosepivirus) in the Republic of Korea. 在大韩民国鉴定出一种新的牛皮卡病毒（Boosepivirus）。

IF 1.5 3区农林科学

Journal of Veterinary Science Pub Date : 2024-09-01 Epub Date: 2024-08-06 DOI: 10.4142/jvs.24148

Jeong-Byoung Chae, Seung-Uk Shin, Serim Kim, Hansong Chae, Won Gyeong Kim, Joon-Seok Chae, Hyuk Song, Jung-Won Kang

{"title":"Identification of a new bovine picornavirus (Boosepivirus) in the Republic of Korea.","authors":"Jeong-Byoung Chae, Seung-Uk Shin, Serim Kim, Hansong Chae, Won Gyeong Kim, Joon-Seok Chae, Hyuk Song, Jung-Won Kang","doi":"10.4142/jvs.24148","DOIUrl":"10.4142/jvs.24148","url":null,"abstract":"Importance: Despite advancements in herd management, feeding, and pharmaceutical interventions, neonatal calf diarrhea (NCD) remains a major global health concern. Bacteria, viruses, and parasites are the major contributors to NCD. Although several pathogens have been identified in the Republic of Korea (ROK), the etiological agents of numerous NCD cases have not been identified.Objective: To identify, for the first time, the prevalence and impact of Boosepivirus (BooV) on calf diarrhea in the ROK.Methods: Here, the unknown cause of calf diarrhea was determined using metagenomics We then explored the prevalence of certain pathogens, including BooV, that cause NCD. Seventy diarrheal fecal samples from Hanwoo (Bos taurus coreanae) calves were analyzed using reverse transcriptase and quantitative real-time polymerase chain reaction for pathogen detection and BooV isolate sequencing.Results: The complete genome of BooV was detected from unknown causes of calf diarrhea. And also, BooV was the most frequently detected pathogen (35.7%) among 8 pathogens in 70 diarrheic feces from Hanwoo calves. Co-infection analyses indicated that most BooV-positive samples were solely infected with BooV, indicating its significance in NCD in the ROK. All isolates were classified as BooV B in phylogenetic analysis.Conclusions and relevance: This is the first study to determine the prevalence and molecular characteristics of BooV in calf diarrhea in the ROK, highlighting the potential importance of BooV as a causative agent of calf diarrhea and highlighting the need for further research on its epidemiology and pathogenicity.","PeriodicalId":17557,"journal":{"name":"Journal of Veterinary Science","volume":" ","pages":"e59"},"PeriodicalIF":1.5,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11450388/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142140456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Alzheimer disease-like neuropathologic changes in a geriatric baboon (Papio hamadryas). 老年狒狒（Papio hamadryas）的阿尔茨海默病样神经病理变化。

IF 1.5 3区农林科学

Journal of Veterinary Science Pub Date : 2024-09-01 Epub Date: 2024-08-07 DOI: 10.4142/jvs.24080

William T Harrison, J Mark Cline, David L Caudell, Hillary F Huber, Carol A Shively, Thomas C Register, Suzanne Craft, Jason D Struthers

{"title":"Alzheimer disease-like neuropathologic changes in a geriatric baboon (Papio hamadryas).","authors":"William T Harrison, J Mark Cline, David L Caudell, Hillary F Huber, Carol A Shively, Thomas C Register, Suzanne Craft, Jason D Struthers","doi":"10.4142/jvs.24080","DOIUrl":"10.4142/jvs.24080","url":null,"abstract":"Importance: Alzheimer's disease (AD) is the most common cause of dementia in the elderly with the incidence rising exponentially after the age of 65 years. Unfortunately, effective treatments are extremely limited and definite diagnosis can only be made at autopsy. This is in part due to our limited understanding of the complex pathophysiology, including the various genetic, environmental, and metabolic contributing factors. In an effort to better understand this complex disease, researchers have employed nonhuman primates as translational models.Case presentation: This report aims to describe the AD-like neuropathology in the brain of a 37-year-old female baboon (Papio hamadryas), which at the time of her death made her the oldest hamadryas baboon at any member institution of the Association of Zoos and Aquariums. A diagnostic necropsy was performed, and the brain was evaluated for neurodegenerative disease. Frequent amyloid-β deposits were identified, consistent with what has been described in other geriatric nonhuman primates. Phospho-tau pathology, including neurofibrillary tangles, a feature not well-described in other primate models, was also abundant.Conclusions and relevance: Our results suggest that more detailed, prospective, longitudinal studies are warranted utilizing this particular species to see if they represent a viable model for human brain aging.","PeriodicalId":17557,"journal":{"name":"Journal of Veterinary Science","volume":" ","pages":"e60"},"PeriodicalIF":1.5,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11450389/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142133089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0