Journal of Veterinary Science最新文献

{"title":"Use of veterinary medicinal products in the Philippines: regulations, impact, challenges, and recommendations.","authors":"Maria Ruth B Pineda-Cortel, Elner H Del Rosario, Oliver B Villaflores","doi":"10.4142/jvs.23134","DOIUrl":"https://doi.org/10.4142/jvs.23134","url":null,"abstract":"<p><p>Agricultural production is a major driver of the Philippine economy. Mass production of animal products, such as livestock and poultry farming, is one of the most prominent players in the field. Filipino farmers use veterinary medicinal products (VMPs) when raising agricultural animals to improve animal growth and prevent diseases. Unfortunately, the extensive use of VMPs, particularly antibiotics, has been linked to drug resistance in animals, particularly antibiotics. Antimicrobial gene products produced in animals due to the prolonged use of VMPs can passed on to humans when they consume animal products. This paper reviews information on the use of VMPs in the Philippines, including the regulations, their impact, challenges, and potential recommendations. The Philippines has existing legislation regulating VMP use. Several agencies were tasked to regulate the use of VMPs, such as the Department of Agriculture, the Department of Health, and the Philippine National Action Plan. Unfortunately, there is a challenge to implementing these regulations, which affects consumers. The unregulated use of VMPs influences the transmission of antibiotic residues from animals to crops to humans. This challenge should be addressed, with more focus on stricter regulation.</p>","PeriodicalId":17557,"journal":{"name":"Journal of Veterinary Science","volume":"25 2","pages":"e33"},"PeriodicalIF":1.8,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10990910/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140853846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Newcastle disease virus: the past and current situation in Indonesia.","authors":"Nlp Indi Dharmayanti, Diana Nurjanah, Harimurti Nuradji, Teguh Suyatno, Risa Indriani","doi":"10.4142/jvs.23022","DOIUrl":"10.4142/jvs.23022","url":null,"abstract":"<p><p>The Newcastle disease virus (NDV) outbreak was first reported in Java Island, Indonesia, in 1926, which was then reported further in Newcastle-upon-Tyne, England. Nevertheless, the NDV is still endemic in Indonesia, with outbreaks occurring in free-range and commercial chicken farms. The dynamic evolution of the NDV has led to the further development of vaccines and diagnostic tools for more effective control of this virus. This paper discusses the history of the NDV occurrence, vaccines, the development of diagnostic tools, and the epidemiological condition of the NDV in Indonesia. Indonesia, which has the largest poultry population in the world after China, has challenges in preventing and controlling this virus that causes economic losses to the farmers and has an impact on the welfare of the poultry farming community in Indonesia.</p>","PeriodicalId":17557,"journal":{"name":"Journal of Veterinary Science","volume":"25 1","pages":"e3"},"PeriodicalIF":1.8,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10839176/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139692166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Proof-of-concept study of the caninized anti-canine programmed death 1 antibody in dogs with advanced non-oral malignant melanoma solid tumors.","authors":"Masaya Igase, Sakuya Inanaga, Shoma Nishibori, Kazuhito Itamoto, Hiroshi Sunahara, Yuki Nemoto, Kenji Tani, Hiro Horikirizono, Munekazu Nakaichi, Kenji Baba, Satoshi Kambayashi, Masaru Okuda, Yusuke Sakai, Masashi Sakurai, Masahiro Kato, Toshihiro Tsukui, Takuya Mizuno","doi":"10.4142/jvs.23144","DOIUrl":"10.4142/jvs.23144","url":null,"abstract":"<p><strong>Background: </strong>The anti-programmed death 1 (PD-1) antibody has led to durable clinical responses in a wide variety of human tumors. We have previously developed the caninized anti-canine PD-1 antibody (ca-4F12-E6) and evaluated its therapeutic properties in dogs with advance-staged oral malignant melanoma (OMM), however, their therapeutic effects on other types of canine tumors remain unclear.</p><p><strong>Objective: </strong>The present clinical study was carried out to evaluate the safety profile and clinical efficacy of ca-4F12-E6 in dogs with advanced solid tumors except for OMM.</p><p><strong>Methods: </strong>Thirty-eight dogs with non-OMM solid tumors were enrolled prospectively and treated with ca-4F12-E6 at 3 mg/kg every 2 weeks of each 10-week treatment cycle. Adverse events (AEs) and treatment efficacy were graded based on the criteria established by the Veterinary Cooperative Oncology Group.</p><p><strong>Results: </strong>One dog was withdrawn, and thirty-seven dogs were evaluated for the safety and efficacy of ca-4F12-E6. Treatment-related AEs of any grade occurred in 13 out of 37 cases (35.1%). Two dogs with sterile nodular panniculitis and one with myasthenia gravis and hypothyroidism were suspected of immune-related AEs. In 30 out of 37 dogs that had target tumor lesions, the overall response and clinical benefit rates were 6.9% and 27.6%, respectively. The median progression-free survival and overall survival time were 70 days and 215 days, respectively.</p><p><strong>Conclusions: </strong>The present study demonstrated that ca-4F12-E6 was well-tolerated in non-OMM dogs, with a small number of cases showing objective responses. This provides evidence supporting large-scale clinical trials of anti-PD-1 antibody therapy in dogs.</p>","PeriodicalId":17557,"journal":{"name":"Journal of Veterinary Science","volume":"25 1","pages":"e15"},"PeriodicalIF":1.8,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10839171/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139692167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endogenous lipid pneumonia in a ringed seal (<i>Pusa hispida</i> subsp. <i>ochotensis</i>).","authors":"Gye-Hyeong Woo","doi":"10.4142/jvs.23263","DOIUrl":"10.4142/jvs.23263","url":null,"abstract":"<p><p>An adult female ringed seal died suddenly and was subsequently examined for diagnostic purposes. The animal's lungs demonstrated mild non-collapsibility and multifocal white to yellow patches. Histopathological examination revealed multifocal pulmonary histiocytosis. Alveoli were filled with numerous foamy macrophages cytoplasm and scattered multinucleated giant cells containing cholesterol clefts. The foamy cytoplasm of the macrophages stained with oil red O stain. Further, lipid droplets within the cytoplasm were detected by electron microscopy. To the author's knowledge, this is the first case report describing the histochemical staining and electron microscopic findings associated with endogenous lipid pneumonia in ringed seal.</p>","PeriodicalId":17557,"journal":{"name":"Journal of Veterinary Science","volume":"25 1","pages":"e14"},"PeriodicalIF":1.8,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10839177/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139692162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Essential oil pharmaceuticals for killing ectoparasites on dogs.","authors":"Phacharaporn Tadee, Sunee Chansakaow, Pramote Tipduangta, Pakpoom Tadee, Pakasinee Khaodang, Kridda Chukiatsiri","doi":"10.4142/jvs.23189","DOIUrl":"10.4142/jvs.23189","url":null,"abstract":"<p><strong>Background: </strong>External parasites, particularly ticks and fleas, are among the most common problems affecting dogs. Chemical medicines are commonly used to prevent and eliminate such external parasites, but their improper use can cause adverse reactions, and the toxins they contain may remain in the environment.</p><p><strong>Objectives: </strong>The objective of this study was to investigate the <i>in vitro</i> efficacy of <i>Zanthoxylum limonella</i>, citronella, clove, peppermint, and ginger essential oils against dog ticks and fleas and to test the sensitivity of dogs' skin to these essential oils.</p><p><strong>Methods: </strong>The five essential oils were tested for in vitro efficacy against ticks and fleas, and the two most effective essential oils were then tested on the dogs' skin.</p><p><strong>Results: </strong>The results revealed that these five essential oils at 16% concentrations effectively inhibited the spawning of female engorged ticks. In addition, all five essential oils had a strong ability to kill tick larvae at concentrations of 2% upward. Furthermore, 4% concentrations of the five essential oils quickly eliminated fleas, especially clove oil, which killed 100% of fleas within 1 h. A 50%, 90%, and 99% lethal concentration (LC₅₀, LC₉₀, and LC₉₉) for the essential oils on tick larvae in 24 h were found to be low values. LC₅₀, LC₉₀, and LC₉₉ for the essential oils on flea in 1 h was lowest values. Clove oil at 16% concentration was the most satisfactory essential oil for application on dogs' skin, with a low percentage of adverse effects.</p><p><strong>Conclusions: </strong>This study confirmed the effectiveness of essential oils for practical use as tick and flea repellents and eliminators. Essential-oil-based pharmaceutical can replace chemical pesticides and provide benefits for both consumers and the environment.</p>","PeriodicalId":17557,"journal":{"name":"Journal of Veterinary Science","volume":"25 1","pages":"e5"},"PeriodicalIF":1.8,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10839170/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139692163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cervical spine reconstruction after total vertebrectomy using customized three-dimensional-printed implants in dogs.","authors":"Ji-Won Jeon, Kyu-Won Kang, Woo-Keyoung Kim, Sook Yang, Byung-Jae Kang","doi":"10.4142/jvs.23241","DOIUrl":"10.4142/jvs.23241","url":null,"abstract":"<p><strong>Background: </strong>Sufficient surgical resection is necessary for effective tumor control, but is usually limited for vertebral tumors, especially in the cervical spine in small animal neurosurgery.</p><p><strong>Objective: </strong>To evaluate the primary stability and safety of customized three-dimensional (3D)-printed implants for cervical spine reconstruction after total vertebrectomy.</p><p><strong>Methods: </strong>Customized guides and implants were designed based on computed tomography (CT) imaging of five beagle cadavers and were 3D-printed. They were used to reconstruct C5 after total vertebrectomy. Postoperative CT images were obtained to evaluate the safety and accuracy of screw positioning. After harvesting 10 vertebral specimens (C3-C7) from intact (group A) and implanted spines (group B), implant stability was analyzed using a 4-point bending test comparing with groups A and C (reconstituted with plate and pins/polymethylmethacrylate after testing in Group A).</p><p><strong>Results: </strong>All customized implants were applied without gross neurovascular damage. In addition, 90% of the screws were in a safe area, with 7.5% in grade 1 (< 1.3 mm) and 2.5% in grade 2 (> 1.3 mm). The mean entry point and angular deviations were 0.81 ± 0.43 mm and 6.50 ± 5.11°, respectively. Groups B and C significantly decreased the range of motion (ROM) in C3-C7 compared with intact spines (<i>p</i> = 0.033, and 0.018). Both groups reduced overall ROM and neutral zone in C4-C6, but only group B showed significance (<i>p</i> = 0.005, and 0.027).</p><p><strong>Conclusion: </strong>Customized 3D-printed implants could safely and accurately replace a cervical vertebra in dog cadavers while providing primary stability.</p>","PeriodicalId":17557,"journal":{"name":"Journal of Veterinary Science","volume":"25 1","pages":"e2"},"PeriodicalIF":1.8,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10839172/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139692160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combined antimicrobial effect of two peptide nucleic acids against <i>Staphylococcus aureus</i> and <i>S. pseudintermedius</i> veterinary isolates.","authors":"Se Kye Kim, Jun Bong Lee, Hyung Tae Lee, Jang Won Yoon","doi":"10.4142/jvs.23265","DOIUrl":"10.4142/jvs.23265","url":null,"abstract":"<p><strong>Background: </strong><i>Staphylococcus aureus</i> and <i>S. pseudintermedius</i> are the major etiological agents of staphylococcal infections in humans, livestock, and companion animals. The misuse of antimicrobial drugs has led to the emergence of antimicrobial-resistant <i>Staphylococcus</i> spp., including methicillin-resistant <i>S. aureus</i> (MRSA) and methicillin-resistant <i>S. pseudintermedius</i> (MRSP). One novel therapeutic approach against MRSA and MRSP is a peptide nucleic acid (PNA) that can bind to the target nucleotide strands and block expression. Previously, two PNAs conjugated with cell-penetrating peptides (P-PNAs), antisense PNA (ASP)-cmk and ASP-deoD, targeting two essential genes in <i>S. aureus</i>, were constructed, and their antibacterial activities were analyzed.</p><p><strong>Objectives: </strong>This study analyzed the combined antibacterial effects of P-PNAs on <i>S. aureus</i> and <i>S. pseudintermedius</i> clinical isolates.</p><p><strong>Methods: </strong><i>S. aureus</i> ATCC 29740 cells were treated simultaneously with serially diluted ASP-cmk and ASP-deoD, and the minimal inhibitory concentrations (MICs) were measured. The combined P-PNA mixture was then treated with <i>S. aureus</i> and <i>S. pseudintermedius</i> veterinary isolates at the determined MIC, and the antibacterial effect was examined.</p><p><strong>Results: </strong>The combined treatment of two P-PNAs showed higher antibacterial activity than the individual treatments. The MICs of two individual P-PNAs were 20 and 25 μM, whereas that of the combined treatment was 10 μM. The application of a combined treatment to clinical <i>Staphylococcus</i> spp. revealed <i>S. aureus</i> isolates to be resistant to P-PNAs and <i>S. pseudintermedius</i> isolates to be susceptible.</p><p><strong>Conclusions: </strong>These observations highlight the complexity of designing ASPs with high efficacy for potential applications in treating staphylococcal infections in humans and animals.</p>","PeriodicalId":17557,"journal":{"name":"Journal of Veterinary Science","volume":"25 1","pages":"e12"},"PeriodicalIF":1.8,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10839180/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139692161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tumor-like lymphoplasmacytic conjunctivitis in the third eyelid in a dog.","authors":"Hyeonu Sung, Jisoo Park, Jury Kim, Seonmi Kang, Gillian C Shaw, Kangmoon Seo","doi":"10.4142/jvs.23222","DOIUrl":"10.4142/jvs.23222","url":null,"abstract":"<p><p>This report aims to describe a case of tumor-like lymphoplasmacytic conjunctivitis in a 7-year-old spayed-female Pomeranian. On complete ophthalmic examination, a mass with papillary projections was noted on the bulbar surface of the right third eyelid. Debulking of the mass was performed while preserving as much of the third eyelid as possible. On the histopathological examination, the mass was diagnosed as lymphoplasmacytic conjunctivitis with mild epithelial hyperplasia. Although a slight regrowth of the mass was noted 3 weeks after surgery, intralesional injection of triamcinolone acetonide led to its disappearance. There was no further recurrence after 5 months.</p>","PeriodicalId":17557,"journal":{"name":"Journal of Veterinary Science","volume":"25 1","pages":"e16"},"PeriodicalIF":1.8,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10839181/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139692168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Basic concepts, recent advances, and future perspectives in the diagnosis of bovine mastitis.","authors":"Samah Attia Algharib, Ali Sobhy Dawood, Lingli Huang, Aizhen Guo, Gang Zhao, Kaixiang Zhou, Chao Li, Jinhuan Liu, Xin Gao, Wanhe Luo, Shuyu Xie","doi":"10.4142/jvs.23147","DOIUrl":"10.4142/jvs.23147","url":null,"abstract":"<p><p>Mastitis is one of the most widespread infectious diseases that adversely affects the profitability of the dairy industry worldwide. Accurate diagnosis and identification of pathogens early to cull infected animals and minimize the spread of infection in herds is critical for improving treatment effects and dairy farm welfare. The major pathogens causing mastitis and pathogenesis are assessed first. The most recent and advanced strategies for detecting mastitis, including genomics and proteomics approaches, are then evaluated . Finally, the advantages and disadvantages of each technique, potential research directions, and future perspectives are reported. This review provides a theoretical basis to help veterinarians select the most sensitive, specific, and cost-effective approach for detecting bovine mastitis early.</p>","PeriodicalId":17557,"journal":{"name":"Journal of Veterinary Science","volume":"25 1","pages":"e18"},"PeriodicalIF":1.8,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10839174/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139692159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring preventive factors against insufficient antibody positivity rate for foot-and-mouth disease in pig farms in South Korea: a preliminary ecological study.","authors":"Dongwoon Han, Byeongwoo Ahn, Kyung-Duk Min","doi":"10.4142/jvs.23185","DOIUrl":"10.4142/jvs.23185","url":null,"abstract":"<p><strong>Background: </strong>Foot-and-mouth disease (FMD) is a highly contagious viral disease in livestock that has tremendous economic impact nationally. After multiple FMD outbreaks, the South Korean government implemented a vaccination policy for efficient disease control. However, during active surveillance by quarantine authorities, pig farms have reported an insufficient antibody positivity rate to FMD.</p><p><strong>Objective: </strong>In this study, the spatial and temporal trends of insufficiency among pig farms were analyzed, and the effect of the number of government veterinary officers was explored as a potential preventive factor.</p><p><strong>Methods: </strong>Various data were acquired, including national-level surveillance data for antibody insufficiency from the Korea Animal Health Integrated System, the number of veterinary officers, and the number of local pig farms. Temporal and geographical descriptive analyses were conducted to overview spatial and temporal trends. Additionally, logistic regression models were employed to investigate the association between the number of officers per pig farm with antibody insufficiency. Spatial cluster analysis was conducted to detect spatial clusters.</p><p><strong>Results: </strong>The results showed that the incidence of insufficiency tended to decrease in recent years (odds ratio [OR], 0.803; 95% confidence interval [95% CIs], 0.721-0.893), and regions with a higher density of governmental veterinary officers (OR, 0.942; 95% CIs, 0.918-0.965) were associated with a lower incidence.</p><p><strong>Conclusions: </strong>This study implies that previously conducted national interventions would be effective, and the quality of government-provided veterinary care could play an important role in addressing the insufficient positivity rate of antibodies.</p>","PeriodicalId":17557,"journal":{"name":"Journal of Veterinary Science","volume":"25 1","pages":"e13"},"PeriodicalIF":1.8,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10839178/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139692164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}