香料产品导致的犬氧化性溶血危机:临床见解和治疗方法。

IF 1.5 3区 农林科学 Q2 VETERINARY SCIENCES
Journal of Veterinary Science Pub Date : 2024-09-01 Epub Date: 2024-08-14 DOI:10.4142/jvs.24160
Sully Lee, Kyoung-Won Seo, Urs Giger, Min-Ok Ryu
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引用次数: 0

摘要

重要性:这是首例报告的由香料产品诱发的犬复发性氧化性溶血性贫血病例,详细介绍了所采用的成功治疗方法:一只 4 岁的完整雌性博美犬出现棕色舌头、色素尿、外周水肿和呕吐。血液涂片显示,埃可氏红细胞和海因茨体数量较高,同时充盈细胞体积急剧下降,血液中高铁血红蛋白水平升高,这表明发生了氧化性溶血危象。患者回家后,这种临床病理模式又反复出现了几次。抗氧化剂、亚甲蓝、高压氧(HBO)疗法和输血成功地解决了反复出现的溶血性贫血问题,但氧化性溶血危象再次出现。在主人不再接触各种家庭药剂和香料后,临床症状和溶血危象没有复发:反复出现的氧化性溶血危机应引起对环境毒性的怀疑,虽然环境毒性在少量情况下对人类无害,但却会对小型犬造成破坏。除了去除致病因子外,亚甲蓝和其他抗氧化剂以及 HBO 可能对氧化性溶血性贫血的急性治疗有益。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Oxidative hemolytic crises in a dog due to fragrance products: clinical insights and treatment approaches.

Importance: This is the first reported case of fragrance products-induced recurrent oxidative hemolytic anemia in a dog, detailing the successful therapeutic approach employed.

Case presentation: A 4-year-old intact female Pomeranian dog presented with brown tongue, pigmenturia, peripheral edema, and vomiting. Blood smears revealed a high count of eccentrocytes and Heinz bodies, along with a precipitous decline in packed cell volume and an increase in blood methemoglobin levels, suggesting an oxidative hemolytic crisis. This clinicopathological pattern recurred several times after the patient returned home. Antioxidants, methylene blue, hyperbaric oxygen (HBO) therapy, and blood transfusion were successfully employed to address recurrent hemolytic anemia; however, oxidative hemolytic crises recurred. After the owner removed exposure to various home remedies and fragrances, the clinical signs and hemolytic crises did not recur.

Conclusions and relevance: Recurring oxidative hemolytic crises should raise suspicions of environmental toxicity, which, although harmless in small quantities to humans, can be devastating to small-breed dogs. In addition to removing the causative agents, methylene blue and other antioxidants, along with HBO, may be beneficial in the acute management of oxidative hemolytic anemia.

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来源期刊
Journal of Veterinary Science
Journal of Veterinary Science 农林科学-兽医学
CiteScore
3.10
自引率
5.60%
发文量
86
审稿时长
1.3 months
期刊介绍: The Journal of Veterinary Science (J Vet Sci) is devoted to the advancement and dissemination of scientific knowledge concerning veterinary sciences and related academic disciplines. It is an international journal indexed in the Thomson Scientific Web of Science, SCI-EXPANDED, Sci Search, BIOSIS Previews, Biological Abstracts, Focus on: Veterinary Science & Medicine, Zoological Record, PubMed /MEDLINE, Index Medicus, Pubmed Central, CAB Abstracts / Index Veterinarius, EBSCO, AGRIS and AGRICOLA. This journal published in English by the Korean Society of Veterinary Science (KSVS) being distributed worldwide.
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