Journal of Radiation Research最新文献_第5页

Factors associated with acute radiation-induced nocturia in localized prostate cancer treated with proton beam therapy. 质子束治疗局限性前列腺癌患者急性放射诱发夜尿的相关因素

IF 2.1 4区医学

Journal of Radiation Research Pub Date : 2026-07-24 DOI: 10.1093/jrr/rrag044

Keita Yoshizaki, Yoji Tabata, Koji Yoshioka, Ryosaku Yamada, Yuya Azuma, Kazuya Inoue, Hitoshi Yoshimura

{"title":"Factors associated with acute radiation-induced nocturia in localized prostate cancer treated with proton beam therapy.","authors":"Keita Yoshizaki, Yoji Tabata, Koji Yoshioka, Ryosaku Yamada, Yuya Azuma, Kazuya Inoue, Hitoshi Yoshimura","doi":"10.1093/jrr/rrag044","DOIUrl":"10.1093/jrr/rrag044","url":null,"abstract":"We examined factors associated with acute radiation-induced nocturia (ARIN) in patients with localized prostate cancer (LPC) treated with proton beam therapy (PBT). We included 140 patients who underwent PBT for LPC. Of these, 80 patients with implanted hydrogel spacers were treated with moderately hypo-fractionated proton therapy (MHPT) (60-66 GyRBE in 20-22 fractions) and 60 patients without hydrogel spacers were treated with normo-fractionated proton therapy (NFPT) (74-78 GyRBE in 37-39 fractions). In-room computed tomography was performed for each fraction to monitor target position. Prostate-rectum boundary matching was adopted to effectively reduce rectal dose, and position translation and pitch angle corrections were performed depending on rectal filling changes. ARIN was evaluated based on the nocturnal voiding frequencies. We first performed multivariate logistic regression (MLR) analysis to identify significant factors for ARIN. Subsequently, propensity score matching (PSM) was performed as a sensitivity analysis to address potential confounding and to assess the robustness of the findings. The analyses showed that 45/140 patients experienced ARIN during/immediately after PBT. MLR analysis showed that 'treatment regimen' (MHPT with spacer vs NFPT without spacer) was statistically significantly associated with ARIN (OR: 0.25, 95% CI: 0.09-0.67, P < 0.05). This association remained significant after PSM. In conclusion, while 'treatment regimen' was statistically associated with ARIN, this finding should be interpreted cautiously as reflecting a composite treatment strategy within the limitations of a retrospective analysis, rather than a causal relationship.","PeriodicalId":16922,"journal":{"name":"Journal of Radiation Research","volume":" ","pages":"648-655"},"PeriodicalIF":2.1,"publicationDate":"2026-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13400565/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148376068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

For ultra-high dose rate carbon-ion irradiation, comparable beam parameters induce the equivalent cell sparing (FLASH) effect. 对于超高剂量率的碳离子辐照，相似的光束参数可诱导等效细胞保留（FLASH）效应。

IF 2.1 4区医学

Journal of Radiation Research Pub Date : 2026-07-24 DOI: 10.1093/jrr/rrag039

Kento Tsubouchi, Yukari Yoshida, Masashi Yagi, Kazumasa Minami, Hiromu Suda, Masao Nakao, Ken Yusa, Mutsumi Tashiro, Shinichi Shimizu, Tatsuya Ohno, Kazuhiko Ogawa

{"title":"For ultra-high dose rate carbon-ion irradiation, comparable beam parameters induce the equivalent cell sparing (FLASH) effect.","authors":"Kento Tsubouchi, Yukari Yoshida, Masashi Yagi, Kazumasa Minami, Hiromu Suda, Masao Nakao, Ken Yusa, Mutsumi Tashiro, Shinichi Shimizu, Tatsuya Ohno, Kazuhiko Ogawa","doi":"10.1093/jrr/rrag039","DOIUrl":"10.1093/jrr/rrag039","url":null,"abstract":"Recently, ultra-high dose rate (uHDR) irradiation has received attention for FLASH effect, a phenomenon in vivo that reduces normal-tissue damage without compromising antitumor efficacy compared to normal dose rate (NDR) irradiation. Such protective responses observed in vitro are referred to as cell-sparing effect. In previous studies, the cell-sparing effect was demonstrated using a carbon-ion beam scanning system. This study aimed to reproduce comparable irradiation conditions using a different machine at another facility and evaluate the cell-sparing effect. Comparable beam settings were adopted: physical dose 7 Gy, average dose rates (ADR) 100 Gy/s for uHDR and 1 Gy/s for NDR, dose-averaged linear energy transfer (LETd) 16.3 and 50 keV/μm, and identical scanning patterns. The same cell lines, Human salivary gland cell line (HSGc-C5), human dermal fibroblast (HDF), and human lung bronchial epithelial cell line (Nuli-1), were irradiated under normoxia. Colony formation assay and immunofluorescence staining of γH2AX were performed to assess cell survival and DNA damage. Comparable physical dose, ADR, and field flatness were verified by measurements. HDF and Nuli-1 showed the cell-sparing effects with increased surviving fractions and less DNA damage, which were enhanced at higher LET. In contrast, HSGc-C5 exhibited the smaller cell-sparing effect, being absent at low LET. These results were largely consistent with previous studies. To the best of current knowledge, this study is the first to indicate that the cell-sparing effect depends not on irradiation devices but on beam parameters, contributing to accelerating further FLASH research and clinical implementation of carbon-ion uHDR irradiation.","PeriodicalId":16922,"journal":{"name":"Journal of Radiation Research","volume":" ","pages":"487-497"},"PeriodicalIF":2.1,"publicationDate":"2026-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13400559/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148156902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Radiation effects of a CT scan on chromosomal aberrations in cancer and non-cancer patients. CT扫描对癌症和非癌症患者染色体畸变的辐射影响。

IF 2.1 4区医学

Journal of Radiation Research Pub Date : 2026-07-24 DOI: 10.1093/jrr/rrag014

Yuri Kawashima, Lin Shi, Wataru Fukumoto, Jiying Sun, Kimio Tanaka, Chiemi Sakai, Mari Ishida, Takafumi Ishida, Yukiko Nakano, Gloriamaris Loy-Caraos, Namkhai Bayasgalan, Suvd Bayarjargal, Yoshitaka Kamimura, Hiroshi Aikata, Shinji Yoshinaga, Kazuaki Chayama, Kazuo Awai, Satoshi Tashiro

{"title":"Radiation effects of a CT scan on chromosomal aberrations in cancer and non-cancer patients.","authors":"Yuri Kawashima, Lin Shi, Wataru Fukumoto, Jiying Sun, Kimio Tanaka, Chiemi Sakai, Mari Ishida, Takafumi Ishida, Yukiko Nakano, Gloriamaris Loy-Caraos, Namkhai Bayasgalan, Suvd Bayarjargal, Yoshitaka Kamimura, Hiroshi Aikata, Shinji Yoshinaga, Kazuaki Chayama, Kazuo Awai, Satoshi Tashiro","doi":"10.1093/jrr/rrag014","DOIUrl":"10.1093/jrr/rrag014","url":null,"abstract":"Computed tomography (CT) is indispensable in clinical practice, but the health risks of repeated low-dose radiation exposure remain unclear, especially in relation to potential differences between cancer and non-cancer patients. This study aimed to examine potential differences in biological responses to CT-associated low-dose irradiation between non-cancer patients and patients with hepatocellular carcinoma (HCC). In a prospective observational study, chromosomal aberrations (CAs) in peripheral blood lymphocytes (PBLs) were quantified by fluorescence in situ hybridization analysis with peptide nucleic acid probes (PNA-FISH). Data from 60 non-cancer patients obtained in our previous study were used as control, and 61 HCC patients were newly enrolled. Baseline CA frequencies were significantly higher in HCC patients (30.6 per 1000 cells) than in non-cancer patients (5.6 per 1000 cells; P < 0.0001). Among the 61 HCC patients, those with a history of radiotherapy (RT) exhibited higher baseline CAs (64.8 per 1000 cells) compared with those without RT (n = 49; 22.2 per 1000 cells). In RT-negative HCC patients, a history of TACE also correlated with increased baseline CAs (P < 0.05), suggesting a contribution of prior genotoxic therapies. In HCC patients without prior RT, a history of TACE also correlated with increased baseline CAs (P < 0.05), suggesting a contribution of prior genotoxic therapies. In addition, Notably, CT-induced CA formation was greater in HCC patients with prior RT than in patients without RT (P < 0.05). These results support careful assessment of cumulative medical radiation exposure in cancer patients who undergo repeated imaging and/or treatment.","PeriodicalId":16922,"journal":{"name":"Journal of Radiation Research","volume":" ","pages":"556-567"},"PeriodicalIF":2.1,"publicationDate":"2026-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13400567/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148054860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prioritizing radiotherapy infrastructure in depopulating societies: a 2050 blueprint from Akita, Japan. 在人口减少的社会中优先考虑放射治疗基础设施：日本秋田的2050年蓝图。

IF 2.1 4区医学

Journal of Radiation Research Pub Date : 2026-07-24 DOI: 10.1093/jrr/rrag033

Yuhei Koike, Satoaki Nakamura, Yuki Wada

{"title":"Prioritizing radiotherapy infrastructure in depopulating societies: a 2050 blueprint from Akita, Japan.","authors":"Yuhei Koike, Satoaki Nakamura, Yuki Wada","doi":"10.1093/jrr/rrag033","DOIUrl":"10.1093/jrr/rrag033","url":null,"abstract":"In super-aged and depopulating societies, repeated travel requirements for radiotherapy (RT) can amplify geographic inequities in access to advanced techniques. The aim of this study was to determine optimal placement of intensity-modulated radiotherapy (IMRT)-capable facilities in Akita Prefecture-a leading-edge case of Japan's demographic transition-using p-median optimization under population projections through 2050. Using 1-km mesh population data for 2020 and official projections for 2030, 2040 and 2050, we calculated one-way automobile travel times from each mesh centroid to RT facilities with the Open Source Routing Machine based on OpenStreetMap road data. A 60-min travel-time threshold defined access coverage. IMRT-capable facilities were identified from official insurance-designation lists. Optimal placement was determined using a population-weighted p-median model, with the number of facilities prespecified as one per 200 000 population. In 2020, 10 external-beam RT facilities provided near-universal 60-min coverage (99.99%; mean 12.8 min), whereas the single IMRT-capable facility covered only 70.3% (uncovered 285 273; mean 42.5 min). Optimized placement with five IMRT-capable facilities increased coverage to 99.99% (uncovered 89) and reduced mean travel time to 14.2 min. Under population projections, optimized placement maintained >99% coverage through 2050 with three facilities, and three core locations were consistently selected across all time horizons. These temporally stable core locations can serve as priority targets for long-term IMRT infrastructure investment in aging and depopulating regions.","PeriodicalId":16922,"journal":{"name":"Journal of Radiation Research","volume":" ","pages":"584-590"},"PeriodicalIF":2.1,"publicationDate":"2026-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13400574/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147941720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A model-based selection of oral cancer patient for passive scattering proton beam therapy. 基于模型的口腔癌患者被动散射质子束治疗选择。

IF 2.1 4区医学

Journal of Radiation Research Pub Date : 2026-07-24 DOI: 10.1093/jrr/rrag042

Yuki Narita, Kanako Takayama, Takahiro Kato, Shinya Komori, Ichiro Seto, Tatsuhiko Nakasato, Masao Murakami

{"title":"A model-based selection of oral cancer patient for passive scattering proton beam therapy.","authors":"Yuki Narita, Kanako Takayama, Takahiro Kato, Shinya Komori, Ichiro Seto, Tatsuhiko Nakasato, Masao Murakami","doi":"10.1093/jrr/rrag042","DOIUrl":"10.1093/jrr/rrag042","url":null,"abstract":"Background and purpose: To identify patients with oral cancer (OC) who benefit from proton therapy versus photon therapy using a model-based approach (MBA) to reduce late adverse events.Material/methods: Passive scattering proton beam therapy (PSPT) and volumetric modulated arc therapy (VMAT) plans were established for 40 patients with OC, consisting of a dose of 70 Gy (relative biological effectiveness) in 35 fractions. At least 95% of the planning target volume received 95% of the prescribed dose, and the dose to the organs at risk was restricted to be as low as possible. Normal tissue complication probability (NTCP) was used to estimate the risk of late adverse events, including dysgeusia, xerostomia and osteoradionecrosis of the mandible. Patients who were considered as candidates for PSPT were selected if the NTCP difference between both plans (ΔNTCP) exceeded the threshold defined in the Dutch national indication protocol.Results: PSPT reduced the doses to the spinal cord, pharynx, oral cavity and contralateral salivary glands compared with VMAT. PSPT was also superior for the risk evaluation of each late adverse event calculated by incorporating dose metrics and patient baseline risk factors. For the MBA using ΔNTCP and the thresholds, PSPT was indicated in 24 of the 40 cases, and the remaining 16 cases were considered to be equivalent to VMAT.Conclusion: MBA was used to select OC cases that were candidates for PSPT. Compared with VMAT, the risk of expected late adverse events was significantly reduced with PSPT, and 60% of patients were considered eligible for PSPT.","PeriodicalId":16922,"journal":{"name":"Journal of Radiation Research","volume":" ","pages":"626-633"},"PeriodicalIF":2.1,"publicationDate":"2026-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13400572/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148163495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of materials and beam currents on ozone generation in proton beam irradiation: a phantom study. 质子束辐照中材料和光束电流对臭氧产生的影响：一个模拟研究。

IF 2.1 4区医学

Journal of Radiation Research Pub Date : 2026-07-24 DOI: 10.1093/jrr/rrag031

Taeyoon Kim, Se Byeong Lee, Joo-Young Kim, Tae Hyun Kim, Sung Ho Moon, Byungmoon Park, Kwan-Woo Lee

{"title":"Effects of materials and beam currents on ozone generation in proton beam irradiation: a phantom study.","authors":"Taeyoon Kim, Se Byeong Lee, Joo-Young Kim, Tae Hyun Kim, Sung Ho Moon, Byungmoon Park, Kwan-Woo Lee","doi":"10.1093/jrr/rrag031","DOIUrl":"10.1093/jrr/rrag031","url":null,"abstract":"Some patients undergoing radiation therapy have been reported to experience olfactory sensation. Radiation-induced ozone generation has been proposed as a potential cause, yet the underlying mechanism remains elusive. Previous studies have focused on ozone generation in photon- and electron-beam environments; however, data specific to proton beams remain limited. Using proton irradiation, we measured ozone concentrations at four clinically used beam currents (50, 100, 150 and 200 nA) and under material conditions. A custom-designed phantom was developed to investigate ozone generation during proton beam irradiation using three materials: air, water and bolus. Before conducting the main measurements, we used a high-sensitivity ozone monitor to assess the background ozone concentration in the treatment room over two treatment days, averaging 1.26 ± 0.97 ppb, which is substantially lower than clinically accepted safety thresholds. In air, ozone concentration increased linearly with beam current (R2 = 0.992, P = 0.004), reaching a maximum of 33.60 ppb and a mean of 13.47 ± 2.08 ppb at 200 nA. Water conditions also followed a linear increase (R2 = 0.988, P = 0.006), albeit at a more gradual rate compared to air, with a mean of 8.69 ± 1.12 ppb at 200 nA. However, bolus conditions showed no linear relationship (R2 = 0.081, P = 0.715), with a mean of 8.57 ± 0.87 ppb at 200 nA. Our findings indicate that moisture and airflow can affect ozone concentrations during proton therapy and provide foundational data for elucidating the relationship between ozone levels and patient-reported olfactory sensation in further clinical investigations.","PeriodicalId":16922,"journal":{"name":"Journal of Radiation Research","volume":" ","pages":"568-576"},"PeriodicalIF":2.1,"publicationDate":"2026-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13400561/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147941471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction to: Cost-effectiveness analysis of intensity modulated radiation therapy versus robot-assisted radical prostatectomy for patients with low-risk prostate cancer in Japan. 修正：日本低危前列腺癌患者调强放疗与机器人辅助根治性前列腺切除术的成本-效果分析。

IF 2.1 4区医学

Journal of Radiation Research Pub Date : 2026-07-24 DOI: 10.1093/jrr/rrag065

引用次数: 0

Development of a spatially indexed dose-volume histogram for treatment plan evaluation. 开发用于治疗方案评估的空间索引剂量-体积直方图。

IF 2.1 4区医学

Journal of Radiation Research Pub Date : 2026-07-24 DOI: 10.1093/jrr/rrag050

Hideharu Miura, Shuichi Ozawa, Masahiro Kenjo

{"title":"Development of a spatially indexed dose-volume histogram for treatment plan evaluation.","authors":"Hideharu Miura, Shuichi Ozawa, Masahiro Kenjo","doi":"10.1093/jrr/rrag050","DOIUrl":"10.1093/jrr/rrag050","url":null,"abstract":"Conventional dose-volume histograms (DVHs) lack spatial information, a critical limitation in evaluating carotid artery sparing in laryngeal volumetric-modulated arc therapy (VMAT). We developed a spatially indexed DVH that integrates the distance between the planning target volume (PTV) and carotid arteries for a more comprehensive plan quality assessment. Three representative cases (distant, intermediate, proximal) were analyzed. For each carotid voxel, dose and minimum Euclidean distance to the PTV were calculated. A color-coded cumulative DVH was generated by mapping the mean dose-specific distance (MDD) to a color gradient (red: proximal, blue: distal). Spatial metrics at 35 Gy were derived: minimum distance (dmin,35Gy), mean dose-specific distance (MD35Gy) and V35Gy,10mm (volume ≥35 Gy within 10 mm of PTV surface). The spatially indexed DVH visually identified spatial risk transitions. In the distant case, V35Gy,10mm was negligible (0.1 cc and N/A). In the intermediate case, despite a low conventional V35Gy (0.9 and 1.8 cc), proximity metrics revealed high-risk areas with a dmin,35Gy of 3.2 mm and V35Gy,10mm of 0.8 and 1.4 cc. The proximal case showed the highest risk, with the DVH shifting to red above 30 Gy; nearly all V35Gy (2.4 and 2.3 cc) was within the 10-mm high-risk zone (V35Gy,10mm: 2.0 and 1.7 cc), with a dmin,35Gy of 2.2 and 1.4 mm. The spatially indexed DVH provides an intuitive method to evaluate the spatial relationship between high-dose regions and the PTV, facilitating better risk stratification and optimization in laryngeal VMAT.","PeriodicalId":16922,"journal":{"name":"Journal of Radiation Research","volume":" ","pages":"550-555"},"PeriodicalIF":2.1,"publicationDate":"2026-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13400555/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148456184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Acute skin toxicity and cosmesis outcome in non-metastatic breast cancer patients treated with ultrahypofractionated radiotherapy: a randomized controlled phase II clinical trial comparing proton versus photon radiotherapy. 接受超低分割放疗的非转移性乳腺癌患者的急性皮肤毒性和美容效果：一项比较质子与光子放疗的随机对照II期临床试验

IF 2.1 4区医学

Journal of Radiation Research Pub Date : 2026-07-24 DOI: 10.1093/jrr/rrag037

Thanaporn Sarsitthithum, Chonnipa Nantavithya, Chawalit Lertbutsayanukul, Kitwadee Saksornchai

{"title":"Acute skin toxicity and cosmesis outcome in non-metastatic breast cancer patients treated with ultrahypofractionated radiotherapy: a randomized controlled phase II clinical trial comparing proton versus photon radiotherapy.","authors":"Thanaporn Sarsitthithum, Chonnipa Nantavithya, Chawalit Lertbutsayanukul, Kitwadee Saksornchai","doi":"10.1093/jrr/rrag037","DOIUrl":"10.1093/jrr/rrag037","url":null,"abstract":"The 1-week photon radiotherapy schedule of 26 Gy in 5 fractions is as safe and effective as the standard 3-week schedule of 40 Gy in 15 fractions for adjuvant local radiotherapy in early stage breast cancer. Proton radiotherapy offers dosimetric advantages by reducing heart and lung dose but may be associated with increased acute skin toxicity, and the acute toxicity of ultra-hypofractionated proton therapy remains unknown. In this randomized trial, non-metastatic breast cancer patients were assigned to receive either proton or photon radiotherapy at a dose of 26 Gy in 5 fractions delivered on alternate days, with the aim of comparing acute skin toxicity between the two modalities. Of 140 eligible patients, 72 were included in this interim analysis, with 36 patients in each treatment arm. The highest observed toxicity was grade 2 radiation dermatitis, which occurred in one patient in the proton arm. The incidence of acute radiation dermatitis was significantly higher in the proton arm than in the photon arm (97.2% vs. 75%, P = 0.006), while no significant differences were observed in other acute toxicities. Patients treated with photon radiotherapy demonstrated better cosmetic outcomes (41.7% vs. 13.9%, P = 0.007) and higher satisfaction scores (80.6% vs. 58.3%, P = 0.04) compared with those treated with proton radiotherapy. At a median follow-up of 9 months (IQR: 6-11), no locoregional recurrence was observed in either treatment arm. This interim analysis indicates that ultra-hypofractionated proton therapy is associated with a higher incidence of mild acute radiation dermatitis, whereas photon radiotherapy results in superior cosmetic outcomes and patient satisfaction, with longer follow-up required to determine long-term outcomes.","PeriodicalId":16922,"journal":{"name":"Journal of Radiation Research","volume":" ","pages":"609-617"},"PeriodicalIF":2.1,"publicationDate":"2026-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13400564/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148015925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diabetes mellitus as a potential risk factor for severe late toxicity after stereotactic body radiotherapy for prostate cancer: a large single-institution cohort study. 糖尿病是前列腺癌立体定向放射治疗后严重晚期毒性的潜在危险因素：一项大型单机构队列研究

IF 2.1 4区医学

Journal of Radiation Research Pub Date : 2026-07-24 DOI: 10.1093/jrr/rrag036

Daichi Sugahara, Hideomi Yamashita, Hanano Mizumoto, Hiroyuki Ueno, Yuki Kasuga, Takuya Hayashi, Ayane Yasui, Subaru Sawayanagi, Yuki Nozawa, Mami Ogita

{"title":"Diabetes mellitus as a potential risk factor for severe late toxicity after stereotactic body radiotherapy for prostate cancer: a large single-institution cohort study.","authors":"Daichi Sugahara, Hideomi Yamashita, Hanano Mizumoto, Hiroyuki Ueno, Yuki Kasuga, Takuya Hayashi, Ayane Yasui, Subaru Sawayanagi, Yuki Nozawa, Mami Ogita","doi":"10.1093/jrr/rrag036","DOIUrl":"10.1093/jrr/rrag036","url":null,"abstract":"This study aimed to evaluate the incidence of severe late gastrointestinal and genitourinary toxicities after prostate stereotactic body radiotherapy (SBRT) and to explore potential clinical risk factors, with a particular focus on diabetes mellitus. We retrospectively analyzed patients with clinically non-nodal and non-metastatic prostate cancer treated with SBRT between 2016 and 2024. A total of 940 patients were included. The prescribed doses ranged from 36.25 to 47.5 Gy in five fractions. A total of 29 grade ≥ 3 composite toxicity events (20 gastrointestinal and 14 genitourinary events) were observed. The cumulative incidence of late grade ≥ 3 composite toxicity was 2.5% at 2 years (95% CI, 1.6-3.9%) and 4.6% at 5 years (95% CI, 3.1-6.8%). In univariate analysis, diabetes mellitus was significantly associated with an increased risk of severe toxicity (HR 2.6, 95% CI 1.2-5.4, P = 0.014). Subgroup analyses demonstrated generally consistent associations across clinically relevant subgroups. Although severe late toxicities were infrequent overall, clinically meaningful and potentially devastating events were observed. Exploratory analyses suggested that patient-related clinical factors, including diabetes mellitus, may contribute to increased vulnerability to severe late radiation injury following prostate SBRT and should be considered when interpreting toxicity risk.","PeriodicalId":16922,"journal":{"name":"Journal of Radiation Research","volume":" ","pages":"600-608"},"PeriodicalIF":2.1,"publicationDate":"2026-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13400554/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147964001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0