Journal of Radiation Research最新文献_第5页

Cell-based and extracellular vesicle-based MSC therapies for acute radiation syndrome affecting organ systems. 基于细胞和细胞外囊泡的间充质干细胞疗法治疗影响器官系统的急性辐射综合征。

IF 1.9 4区医学

Journal of Radiation Research Pub Date : 2024-12-16 DOI: 10.1093/jrr/rrae009

Yasuo Miura, Sumie Fujii, Tatsuo Ichinohe

{"title":"Cell-based and extracellular vesicle-based MSC therapies for acute radiation syndrome affecting organ systems.","authors":"Yasuo Miura, Sumie Fujii, Tatsuo Ichinohe","doi":"10.1093/jrr/rrae009","DOIUrl":"10.1093/jrr/rrae009","url":null,"abstract":"Exposure to ionizing radiation can induce harmful biological effects on the human body, particularly in cases of high-dose γ-irradiation affecting the gastrointestinal tract, bone marrow, skin and lung. Such exposures lead to lethal outcomes as individuals experience a breakdown in their immune system's ability to defend against pathogens, predisposing them to sepsis-induced multiple organ failures. Mesenchymal stromal/stem cells (MSCs) possess diverse biological characteristics, including immunomodulation, anti-inflammation and tissue regeneration. Off-the-shelf culture-expanded human bone marrow- or adipose tissue-derived MSCs are clinically available to treat graft-versus-host disease following hematopoietic cell transplantation and perianal fistulas in Crohn's disease in Japan. While preclinical studies showcase encouraging outcomes in radiation-induced injuries, the effectiveness of MSC transplantation in addressing acute radiation syndrome affecting organs in irradiated individuals is limited. Recent studies have highlighted MSC-releasing extracellular vesicles as nanoparticle substances responsible for outlining the mechanism of action and have identified various components, including proteins and microRNA, that serve as functional molecules. MSC-releasing extracellular vesicle-based therapy emerges as a promising avenue, offering a potential solution to the challenges posed by radiation-induced injuries. However, further investigation is required, especially regarding whether MSC-releasing extracellular vesicles have regenerative effects on tissue-resident stem cells. These unresolved issues represent key aspects that need to be addressed to optimize the therapeutic potential of cell-based and extracellular vesicle-based MSC therapies for interventions in the context of radiation-induced injuries.","PeriodicalId":16922,"journal":{"name":"Journal of Radiation Research","volume":"65 Supplement_1","pages":"i80-i87"},"PeriodicalIF":1.9,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11647929/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142829096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Myelodysplastic syndromes among atomic bomb survivors in Nagasaki: similarities to and differences from de novo and therapy-related cases. 长崎原子弹爆炸幸存者骨髓增生异常综合征：与新发病例和治疗相关病例的异同。

IF 1.9 4区医学

Journal of Radiation Research Pub Date : 2024-12-15 DOI: 10.1093/jrr/rrae003

Koji Ando, Yasushi Miyazaki

引用次数: 0

A simulation study of MR-guided proton therapy system using iron-yoked superconducting open MRI: a conceptual study. 使用铁轭超导开放式磁共振成像的磁共振引导质子治疗系统模拟研究：概念研究。

IF 1.9 4区医学

Journal of Radiation Research Pub Date : 2024-12-03 DOI: 10.1093/jrr/rrae075

Yusuke Fujii, Hideaki Ueda, Taisuke Takayanagi, Kentaro Nishioka, Takashi Mori, Takayuki Hashimoto, Hidefumi Aoyama, Kikuo Umegaki, Taeko Matsuura

{"title":"A simulation study of MR-guided proton therapy system using iron-yoked superconducting open MRI: a conceptual study.","authors":"Yusuke Fujii, Hideaki Ueda, Taisuke Takayanagi, Kentaro Nishioka, Takashi Mori, Takayuki Hashimoto, Hidefumi Aoyama, Kikuo Umegaki, Taeko Matsuura","doi":"10.1093/jrr/rrae075","DOIUrl":"10.1093/jrr/rrae075","url":null,"abstract":"Radiotherapy platforms integrated with magnetic resonance imaging (MRI) have been significantly successful and widely used in X-ray therapy over the previous decade. MRI provides greater soft-tissue contrast than conventional X-ray techniques, which enables more precise radiotherapy with on-couch adaptive treatment planning and direct tracking of moving tumors. The integration of MRI into a proton beam irradiation system (PBS) is still in the research stage. However, this could be beneficial as proton therapy is more sensitive to anatomical changes and organ motion. In this simulation study, we considered the integration of PBS into the 0.3-T superconducting open MRI system. Our proposed design involves proton beams traversing a hole at the center of the iron yoke, which allows for a reduced fringe field in the irradiation nozzle while maintaining a large proton scan field of the current PBS. The shape of the bipolar MRI magnets was derived to achieve a large MRI field-of-view. To monitor the beam position and size accurately while maintaining a small beam size, the beam monitor installation was redesigned from the current system. The feasibility of this system was then demonstrated by the treatment plan quality, which showed that the magnetic field did not deteriorate the plan quality from that without the magnetic field for both a rectangular target and a prostate case. Although numerous challenges remain before the proposed simulation model can be implemented in a clinical setting, the presented conceptual design could assist in the initial design for the realization of the MR-guided proton therapy.","PeriodicalId":16922,"journal":{"name":"Journal of Radiation Research","volume":" ","pages":"824-835"},"PeriodicalIF":1.9,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11629991/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142375601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Internal radiation dose estimates in organs of Wistar rats exposed to sprayed neutron-activated 31SiO2 microparticles: first results of international multicenter study. 暴露于喷射中子活化 31SiO2 微粒子的 Wistar 大鼠器官中的内辐射剂量估算：国际多中心研究的首批结果。

IF 1.9 4区医学

Journal of Radiation Research Pub Date : 2024-12-03 DOI: 10.1093/jrr/rrae063

Valeriy Stepanenko, Hitoshi Sato, Andrey Kaprin, Nariaki Fujimoto, Almagul Kushugulova, Sergey Ivanov, Peter Shegay, Viktoria Bogacheva, Alexey Petukhov, Kassym Zhumadilov, Evgenia Ostroumova, Hiroshi Yasuda, Noriyuki Kawano, Megu Ohtaki, Satoru Endo, Aya Sakaguchi, Laura Chulenbayeva, Nurislam Mukhanbetzhanov, Masaharu Hoshi

{"title":"Internal radiation dose estimates in organs of Wistar rats exposed to sprayed neutron-activated 31SiO2 microparticles: first results of international multicenter study.","authors":"Valeriy Stepanenko, Hitoshi Sato, Andrey Kaprin, Nariaki Fujimoto, Almagul Kushugulova, Sergey Ivanov, Peter Shegay, Viktoria Bogacheva, Alexey Petukhov, Kassym Zhumadilov, Evgenia Ostroumova, Hiroshi Yasuda, Noriyuki Kawano, Megu Ohtaki, Satoru Endo, Aya Sakaguchi, Laura Chulenbayeva, Nurislam Mukhanbetzhanov, Masaharu Hoshi","doi":"10.1093/jrr/rrae063","DOIUrl":"10.1093/jrr/rrae063","url":null,"abstract":"Neutron-activated 31Si is an almost pure beta emitter and is one of the short-lived radionuclides, including beta-gamma emitter 56Mn, which were created in a form of residual radioactivity in the early period after the atomic bombing of Hiroshima and Nagasaki. The features of the biological effects of internal irradiation by these radionuclides are a subject of scientific discussions and research. The publication presents data on internal radiation doses in experimental Wistar rats that were exposed to sprayed neutron-activated microparticles of 31SiO2. Doses of internal radiation could be conditionally divided into three groups according to their values. It has been found that elevated values of internal radiation doses in rats' organs/tissues as a result of exposure to sprayed 31SiO2 microparticles with initial activity of 3.2 × 107 Bq varied from 10 to 120 mGy (eyes, lungs, skin, stomach, jejunum, large intestine). The moderate dose values were in the range from 1.9 to 3.7 mGy (trachea, esophagus, ileum). The smallest doses were received by the kidney, testis, blood, cerebellum, heart, liver, cerebrum, bladder, spleen and thymus (from 0.11 to 0.94 mGy). The obtained data are important for interpreting the results of ongoing and planned biological experiments with 31SiO2 microparticles-in comparison with the previously published data on features of biological effects caused by beta-gamma emitting 56MnO2 neutron-activated microparticles.","PeriodicalId":16922,"journal":{"name":"Journal of Radiation Research","volume":" ","pages":"744-751"},"PeriodicalIF":1.9,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11630057/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142400569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical efficacy and safety of neoadjuvant chemotherapy with paclitaxel and cisplatin in combination with concurrent chemoradiotherapy for locally advanced cervical cancer: a systematic review and meta-analysis. 紫杉醇和顺铂新辅助化疗联合同期化放疗治疗局部晚期宫颈癌的临床疗效和安全性：系统综述和荟萃分析。

IF 1.9 4区医学

Journal of Radiation Research Pub Date : 2024-12-03 DOI: 10.1093/jrr/rrae073

Penpa Yeshe, Fang Li

{"title":"Clinical efficacy and safety of neoadjuvant chemotherapy with paclitaxel and cisplatin in combination with concurrent chemoradiotherapy for locally advanced cervical cancer: a systematic review and meta-analysis.","authors":"Penpa Yeshe, Fang Li","doi":"10.1093/jrr/rrae073","DOIUrl":"10.1093/jrr/rrae073","url":null,"abstract":"The meta-analysis was to evaluate the therapeutic benefits of neoadjuvant chemotherapy (NACT), primarily consisting of platinum-based regimens in conjunction with paclitaxel, when integrated with concurrent chemoradiotherapy (CCRT) for individuals afflicted with locally advanced cervical cancer (LACC). The outcomes were determined by overall survival (OS), progression-free survival (PFS), complete response rate (CRR), objective response rate, recurrence rate and adverse events. The assessment of these outcomes was based on the relative risk (RR) accompanied by its 95% confidence interval (CI). Eight articles were included for analysis. LACC patients who underwent treatment with paclitaxel combined with cisplatin (TP)-based NACT in conjunction with CCRT demonstrated improved OS at 2 (RR: 1.11, 95% CI: 1.07, 1.16, P < 0.001), 3 (RR: 1.30, 95% CI: 1.23, 1.37, P < 0.001) and 5 years (RR: 1.20, 95% CI: 1.10, 1.32, P < 0.001), as well as PFS at 1 (RR: 1.03, 95% CI: 1.00, 1.06, P = 0.035), 2 (RR: 1.21, 95% CI: 1.04, 1.40, P = 0.012), 3 (RR: 1.26, 95% CI: 1.17, 1.34, P < 0.001) and 5 (RR: 1.39, 95% CI: 1.25, 1.55, P < 0.001) years, when compared with patients who received CCRT alone. Moreover, the TP-based NACT in conjunction with CCRT achieved a higher CRR and exhibited a lower rate of disease recurrence (RR:1.28, 95% CI:1.08, 1.50, P = 0.003). No significant differences in the risk of adverse effects including anemia, leukopenia, thrombocytopenia, radiocystitis and radiation enteritis between the group treated with TP-based NACT combined with CCRT and the group treated with CCRT alone were observed. The combination of TP-based NACT and CCRT demonstrates superior clinical efficacy than CCRT alone. This study may contribute to reducing the burden of LACC by using TP-based NACT plus CCRT.","PeriodicalId":16922,"journal":{"name":"Journal of Radiation Research","volume":" ","pages":"733-743"},"PeriodicalIF":1.9,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11630013/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142381159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Investigation of interfractional range variation owing to anatomical changes with beam directions based on water equivalent thickness in proton therapy for pancreatic cancer. 根据质子治疗胰腺癌时的水等效厚度，研究解剖学变化导致的射束方向点间范围变化。

IF 1.9 4区医学

Journal of Radiation Research Pub Date : 2024-12-03 DOI: 10.1093/jrr/rrae069

Yuhei Kikkawa, Hideaki Ueda, Yusuke Uchinami, Norio Katoh, Hidefumi Aoyama, Yoichi M Ito, Kohei Yokokawa, Ye Chen, Taeko Matsuura, Naoki Miyamoto, Seishin Takao

{"title":"Investigation of interfractional range variation owing to anatomical changes with beam directions based on water equivalent thickness in proton therapy for pancreatic cancer.","authors":"Yuhei Kikkawa, Hideaki Ueda, Yusuke Uchinami, Norio Katoh, Hidefumi Aoyama, Yoichi M Ito, Kohei Yokokawa, Ye Chen, Taeko Matsuura, Naoki Miyamoto, Seishin Takao","doi":"10.1093/jrr/rrae069","DOIUrl":"10.1093/jrr/rrae069","url":null,"abstract":"To assess the interfractional anatomical range variations (ARVs) with beam directions and their impact on dose distribution in intensity modulated proton therapy, we analyzed water equivalent thickness (WET) from 10 patients with pancreatic cancer. The distributions of the interfractional WET difference ($Delta{mathrm{WET}}^{theta }$) across 360° were visualized using polar histograms. Interfractional ARVs were evaluated using the mean absolute error and ΔWET pass rate, indicating the percentage of $Delta mathrm{WE}{mathrm{T}}^{theta }$ < thresholds. The impact on dose distribution in proton therapy was evaluated based on two treatment plans for 40 Gy(RBE)/5 fractions: 'Plan A', using two beam angles, in which the target was closest to the body surface among four perpendicular directions; and 'Plan B', using two beam angles with small ARVs. Analysis revealed individual variations in angular trends of interfractional ARVs. Three distinct trends were identified: Group 1 exhibited small ARVs around posterior directions; Group 2 exhibited small ARVs except ~60°; Group 3 demonstrated minimal ARVs only ~90°. In dose evaluation, while 150° and 210° were selected in Plan B for 9 out of 10 patients, for the remaining patient, 60° and 90° were chosen. Comparing dose volume histogram parameters for all patients, Plan B significantly reduced target coverage loss while maintaining organ-at-risk sparing comparable to Plan A. These results demonstrated that selecting beam angles with small interfractional ARVs for each patient enhances the robustness of dose distribution, reducing target coverage loss.","PeriodicalId":16922,"journal":{"name":"Journal of Radiation Research","volume":" ","pages":"813-823"},"PeriodicalIF":1.9,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11629986/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142391367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Current status of the working environment of brachytherapy in Japan: a nationwide survey-based analysis focusing on radiotherapy technologists and medical physicists. 日本近距离放射治疗工作环境的现状：以放射治疗技术人员和医学物理学家为重点的全国性调查分析。

IF 1.9 4区医学

Journal of Radiation Research Pub Date : 2024-12-03 DOI: 10.1093/jrr/rrae082

Toru Kojima, Hiroyuki Okamoto, Masahiko Kurooka, Naoki Tohyama, Ichiro Tsuruoka, Mikio Nemoto, Kohei Shimomura, Atsushi Myojoyama, Hitoshi Ikushima, Tatsuya Ohno, Hiroshi Ohnishi

{"title":"Current status of the working environment of brachytherapy in Japan: a nationwide survey-based analysis focusing on radiotherapy technologists and medical physicists.","authors":"Toru Kojima, Hiroyuki Okamoto, Masahiko Kurooka, Naoki Tohyama, Ichiro Tsuruoka, Mikio Nemoto, Kohei Shimomura, Atsushi Myojoyama, Hitoshi Ikushima, Tatsuya Ohno, Hiroshi Ohnishi","doi":"10.1093/jrr/rrae082","DOIUrl":"10.1093/jrr/rrae082","url":null,"abstract":"Brachytherapy (BT), especially in high dose rate (HDR), has become increasingly complex owing to the use of image-guided techniques and the introduction of advanced applicators. Consequently, radiotherapy technologists and medical physicists (RTMPs) require substantial training to enhance their knowledge and technical skills in image-guided brachytherapy. However, the current status of the RTMP workload, individual abilities and quality control (QC) of BT units in Japan remains unclear. To address this issue, we conducted a questionnaire survey from June to August 2022 in all 837 radiation treatment facilities in Japan involving RTMPs. This survey focused on gynecological cancers treated with HDR-BT (GY-HDR) and permanent prostate implantation using low-dose-rate BT (PR-LDR). The responses revealed that the average working time in the overall process for HDR varied: 120 min for intracavitary BT and 180 min for intracavitary BT combined with interstitial BT. The QC implementation rate, in accordance with domestic guidelines, was 65% for GY-HDR and 44% for PR-LDR, which was lower than the 69% observed for external beam radiation therapy (EBRT). Additionally, the implementation rate during regular working hours was low. Even among RTMP working in facilities performing BT, the proportion of those able to perform QC for BT units was ~30% for GY-HDR and <20% for PR-LDR, significantly lower than the 80% achieved for EBRT. This study highlights the vulnerabilities of Japan's BT unit QC implementation structure. Addressing these issues requires appropriate training of the RTMP staff to safely perform BT tasks and improvements in practical education and training systems.","PeriodicalId":16922,"journal":{"name":"Journal of Radiation Research","volume":" ","pages":"851-861"},"PeriodicalIF":1.9,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11629993/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142502589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of neutron beam properties on dose distributions in a water phantom for boron neutron capture therapy. 中子束特性对硼中子俘获疗法水模型中剂量分布的影响。

IF 1.9 4区医学

Journal of Radiation Research Pub Date : 2024-12-03 DOI: 10.1093/jrr/rrae076

Akihisa Ishikawa, Hiroki Tanaka, Satoshi Nakamura, Hiroaki Kumada, Yoshinori Sakurai, Kenichi Watanabe, Sachiko Yoshihashi, Yuki Tanagami, Akira Uritani, Yoshiaki Kiyanagi

{"title":"Effect of neutron beam properties on dose distributions in a water phantom for boron neutron capture therapy.","authors":"Akihisa Ishikawa, Hiroki Tanaka, Satoshi Nakamura, Hiroaki Kumada, Yoshinori Sakurai, Kenichi Watanabe, Sachiko Yoshihashi, Yuki Tanagami, Akira Uritani, Yoshiaki Kiyanagi","doi":"10.1093/jrr/rrae076","DOIUrl":"10.1093/jrr/rrae076","url":null,"abstract":"From the viewpoints of the advantage depths (ADs), peak tumor dose and skin dose, we evaluated the effect on the dose distribution of neutron beam properties, namely the ratio between thermal and epithermal neutron fluxes (thermal/epithermal ratio), fast neutron component and γ-ray component. Several parameter surveys were conducted with respect to the beam properties of neutron sources for boron neutron capture therapy assuming boronophenylalanine as the boron agent using our dose calculation tool, called SiDE. The ADs decreased by 3% at a thermal/epithermal ratio of 20-30% compared with the current recommendation of 5%. The skin dose increased with the increasing thermal/epithermal ratio, reaching a restricted value of 14 Gyeq at a thermal/epithermal ratio of 48%. The fast neutron component was modified using two different models, namely the 'linear model', in which the fast neutron intensity decreases log-linearly with the increasing neutron energy, and the 'moderator thickness (MT) model', in which the fast neutron component is varied by adjusting the MT in a virtual beam shaping assembly. Although a higher fast neutron component indicated a higher skin dose, the increment was <10% at a fast neutron component of <1 × 10-12 Gy cm2 for both models. Furthermore, in the MT model, the epithermal neutron intensity at a fast neutron component of 6.8 × 10-13 Gy cm2 was 41% higher compared with that of 2 × 10-13 Gy cm2. The γ-ray component also caused no significant disadvantages up to several times larger compared with the current recommendation.","PeriodicalId":16922,"journal":{"name":"Journal of Radiation Research","volume":" ","pages":"765-775"},"PeriodicalIF":1.9,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11630089/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142381160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dosimetric commissioning of a high-resolution CMOS 2D detector array for patient-specific QA of single-isocenter multi-target VMAT stereotactic radiosurgery. 高分辨率 CMOS 2D 探测器阵列的剂量调试，用于单中心多靶点 VMAT 立体定向放射手术的患者特异性质量保证。

IF 1.9 4区医学

Journal of Radiation Research Pub Date : 2024-12-03 DOI: 10.1093/jrr/rrae080

Ching-Ling Teng, Shih-Chi Lin, Dale Michael Lovelock, Seng Boh Lim

{"title":"Dosimetric commissioning of a high-resolution CMOS 2D detector array for patient-specific QA of single-isocenter multi-target VMAT stereotactic radiosurgery.","authors":"Ching-Ling Teng, Shih-Chi Lin, Dale Michael Lovelock, Seng Boh Lim","doi":"10.1093/jrr/rrae080","DOIUrl":"10.1093/jrr/rrae080","url":null,"abstract":"Stereotactic radiosurgery (SRS) using the single-isocenter-multiple-target (SIMT) technique by volumetric modulated arc therapy is increasingly popular for treating multiple brain metastases. However, the complex nature of SIMT SRS necessitates rigorous patient-specific quality assurance (PSQA). This study presents a multi-institutional dosimetric commissioning of a high-resolution complementary metal oxide semiconductor (CMOS) 2D detector array, the myQA SRS device for SIMT SRS PSQA. Basic dosimetric properties such as dose-rate, field-size, energy and angular dependencies were characterized for the CMOS detectors. Additionally, gamma index analyses were performed between the measured dose and the films for nine simulated and clinical plans. The results showed that the CMOS detector was dose-rate, field-size, energy and beam-angle dependent. Specific to SIMT SRS, angular dependence on gantry rotations was invariant to couch rotations but was sensitive to off-isocenter distances. With appropriate dose calibration and angular corrections, myQA SRS showed a high dosimetric correlation with films. The average gamma index pass rates were 99.9 ± 0.03% and 99.2 ± 1.1% at 3%/2 mm/10%thr(global) and 1 mm/1%/10%thr(local) criteria, respectively. The average dose difference between myQA SRS and films was 0.4 ± 1.3%. In conclusion, the CMOS 2D detector array has demonstrated its potential as a reliable tool for PSQA for SIMT SRS. The excellent dosimetric agreement with the films was consistent in multiple institutions, further validating the dosimetric accuracy and reproducibility. It provides a timely alternative to film dosimetry for commissioning and quality assurance.","PeriodicalId":16922,"journal":{"name":"Journal of Radiation Research","volume":" ","pages":"787-797"},"PeriodicalIF":1.9,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11629995/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142468402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

High-throughput, low-cost FLASH: irradiation of Drosophila melanogaster with low-energy X-rays using time structures spanning conventional and ultrahigh dose rates. 高通量、低成本 FLASH：利用跨越常规和超高剂量率的时间结构，用低能量 X 射线辐照黑腹果蝇。

IF 1.9 4区医学

Journal of Radiation Research Pub Date : 2024-12-03 DOI: 10.1093/jrr/rrae079

Alexander Hart, Jan P Dudzic, Jameson W Clarke, Jonathan Eby, Steve J Perlman, Magdalena Bazalova-Carter

{"title":"High-throughput, low-cost FLASH: irradiation of Drosophila melanogaster with low-energy X-rays using time structures spanning conventional and ultrahigh dose rates.","authors":"Alexander Hart, Jan P Dudzic, Jameson W Clarke, Jonathan Eby, Steve J Perlman, Magdalena Bazalova-Carter","doi":"10.1093/jrr/rrae079","DOIUrl":"10.1093/jrr/rrae079","url":null,"abstract":"FLASH radiotherapy is an emerging technique in radiation oncology that may improve clinical outcomes by reducing normal tissue toxicities. The physical radiation characteristics needed to induce the radiobiological benefits of FLASH are still an active area of investigation. To determine the dose rate, range of doses and delivery time structure necessary to trigger the FLASH effect, Drosophila melanogaster were exposed to ultrahigh dose rate (UHDR) or conventional radiotherapy dose rate (CONV) 120-kVp X-rays. A conventional X-ray tube outfitted with a shutter system was used to deliver 17- to 44-Gy doses to third-instar D. melanogaster larvae at both UHDR (210 Gy/s) and CONV (0.2-0.4 Gy/s) dose rates. The larvae were then tracked through development to adulthood and scored for eclosion and lifespan. Larvae exposed to UHDR eclosed at higher rates and had longer median survival as adults compared to those treated with CONV at the same doses. Eclosion rates at 24 Gy were 68% higher for the UHDR group (P < 0.05). Median survival from 22 Gy was >22 days for UHDR and 17 days for CONV (P < 0.01). Two normal tissue-sparing effects were observed for D. melanogaster irradiated with UHDR 120-kVp X-rays. The effects appeared only at intermediate doses and may be useful in establishing the dose range over which the benefits of FLASH can be obtained. This work also demonstrates the usefulness of a high-throughput fruit fly model and a low-cost X-ray tube system for radiobiological FLASH research.","PeriodicalId":16922,"journal":{"name":"Journal of Radiation Research","volume":" ","pages":"836-844"},"PeriodicalIF":1.9,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11629999/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142468403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0