Journal of Radiation Research最新文献

{"title":"Efficacy and safety of risk-adapted modified stereotactic body radiotherapy for lung tumors: a single-institution retrospective study.","authors":"Akiko Oka, Hideomi Yamashita, Yosuke Miki, Subaru Sawayanagi, Yuki Nozawa, Daichi Sugahara, Takuya Hayashi, Tenyoh Suzuki, Atsuto Katano","doi":"10.1093/jrr/rrag086","DOIUrl":"https://doi.org/10.1093/jrr/rrag086","url":null,"abstract":"<p><p>This study evaluated the clinical outcomes and safety of risk-adapted stereotactic body radiotherapy (SBRT) using non-standard fractionation schedules for lung tumors adjacent to organs at risk (OARs). We retrospectively analyzed 81 consecutive patients (92 lesions, 2008-25) who received SBRT, including repeat irradiation outside prior fields, with non-standard regimens (56 Gy/7 fractions [fr], 50 Gy/10 fr, 60 Gy/10 fr, 48 Gy/6 fr and 35 Gy/5 fr). Endpoints included overall survival (OS), cancer-specific survival (CSS), progression-free survival (PFS), locoregional progression-free survival, local control (LC) and Grade ≥ 3 adverse events. At a median follow-up of 22.2 months (IQR, 12.1-42.9), the median OS was 26.4 months (95% CI: 17.2-43.0), with 1- and 3-year OS rates of 78.6% and 44.1%, respectively. The median PFS was 14.5 months (95% CI: 9.4-21.1), and the median CSS was 43.7 months (95% CI, 22.7-64.4). Median LC was not reached. No significant survival disparities were identified between primary and metastatic cohorts. Grade ≥ 3 toxicities occurred in 10 patients (12.3%), including two Grade 5 events. The 3-year cumulative incidence of Grade ≥ 3 toxicity in ultracentral tumors was 12.6%, with no significant differences among groups. In conclusion, risk-adapted SBRT with increased fractionation demonstrated encouraging LC while maintaining an acceptable toxicity profile for central and ultracentral lung tumors. However, the risk of severe toxicity remains, requiring careful patient selection and optimized OAR dose constraints.</p>","PeriodicalId":16922,"journal":{"name":"Journal of Radiation Research","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149039505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endoscopic ultrasound-guided fiducial marker placement for image-guided proton beam therapy in pancreatic cancer: implications for positional accuracy and position management.","authors":"Kazunori Takeuchi, Takuya Ishikawa, Kentaro Yamao, Yasuyuki Mizutani, Tadashi Iida, Yoshihisa Takada, Masashi Tomida, Takeshi Yanagi, Yuta Shibamoto, Takahiro Toyama, Kenji Yamao, Makoto Narita, Reiko Ashida, Takeshi Yamamura, Hiroki Kawashima","doi":"10.1093/jrr/rrag082","DOIUrl":"https://doi.org/10.1093/jrr/rrag082","url":null,"abstract":"<p><p>High geometric precision is essential in proton beam therapy (PBT) for pancreatic cancer. This study evaluated inter-fraction positional accuracy during image-guided PBT using radiopaque surrogates and assessed endoscopic ultrasound-guided fiducial marker placement (EUS-FP). Patients with pancreatic cancer treated with PBT between 2020 and 2024 were retrospectively reviewed. The positional accuracy cohort included 58 patients with a radiopaque surrogate (fiducial marker group, n = 46; biliary stent group, n = 12). Major positional deviation was defined as a couch displacement ≥5 mm after bony alignment. Factors associated with major positional deviation were analyzed using generalized estimating equations. Oncologic outcomes were analyzed in patients with unresectable locally advanced (UR-LA) pancreatic cancer receiving concurrent chemoradiotherapy (n = 27). EUS-FP was technically successful in 45/46 patients (98%), with mild adverse events in 13%. Major positional deviation occurred in 18.5%, 30.9% and 11.2% of setups in the left-right, cranio-caudal and antero-posterior directions, respectively. Tumor location and disease status were independently associated with major positional deviation, whereas surrogate type was not. Pancreatic head tumors showed a higher risk than tail tumors, while UR-LA cases demonstrated greater positional stability. Overall survival from diagnosis did not differ significantly between surrogate groups; the median follow-up was 14.9 months. These findings indicate that positional deviation during PBT is primarily driven by tumor-related characteristics rather than the type of radiopaque surrogate used for image guidance. Although biliary stents may serve as radiopaque surrogates in selected cases, EUS-FP is a safe and reproducible technique enabling image-guided PBT.</p>","PeriodicalId":16922,"journal":{"name":"Journal of Radiation Research","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149039457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Current practices and challenges in inverse planning for gynecologic brachytherapy: insights from a multi-institutional study.","authors":"Hiroyuki Okamoto, Ayaka Nagao, Masahiro Morimoto, Setsuo Tamenaga, Yoshihiro Ueda, Tomoko Kawamura, Noriko Ii, Kenji Yoshida, Hiromi Sakaguchi, Soichiro Ito, Yoshifumi Oku, Keiji Matsumoto, Naoya Murakami, Noriyuki Okonogi, Jun Takatsu, Kotaro Iijima, Kazutoshi Murata, Hiroki Ushijima, Ken Ando, Tatsuya Ohno","doi":"10.1093/jrr/rrag084","DOIUrl":"https://doi.org/10.1093/jrr/rrag084","url":null,"abstract":"<p><p>This study investigated the feasibility and reproducibility of inverse planning (IP) in gynecologic high-dose-rate brachytherapy (BT) across ten institutions (five IP and five manual). Two pre-defined cases (high-risk clinical target volume, CTVHR: 62.8 and 27.4 cm3) included the organs at risk (OARs), a tandem, ovoids, and 8 and 3 interstitial needles, respectively. Each institution generated BT plans according to its policy, assuming 30 Gy/15 fractions of whole-pelvis irradiation and 20 Gy/10 fractions of central shielding. Plans were evaluated using dose-volume histogram (DVH) parameters. Dwell-time distributions were compared with conventional Manchester-based pear-shaped plans to identify deviations (e.g. needle dominance and high-dose characteristics) that may not be captured by DVH alone. Institutional interviews assessed clinical acceptability and optimization strategies. All plans were considered clinically acceptable, with no significant differences between IP and non-IP groups in CTVHR  D90% and OARs ${{D}}_{{2} {mathrm{cm}}^{{3}}}$. IP institutions used institution-specific strategies to preserve uterine dose conformity, including fixing dwell times for selected applicators and applying optimization constraints based on Manchester-derived contours, delineated ovoids or delineated uterine structures. Overall, IP plans were comparable to non-IP plans for CTVHR  D90%, CTVHR  V100% (cm3) and OARs ${{D}}_{{2} {mathrm{cm}}^{{3}}}$. In contrast, differences in dose distribution around the uterine fundus and the wide range of the body V100% (cm3) suggested varying institutional strategies for fundus dose. These findings highlight the need for planning QA that incorporates dwell-time review in addition to DVH parameters, and provide a foundation for optimizing and standardizing IP in gynecologic BT to improve planning reproducibility and patient outcomes.</p>","PeriodicalId":16922,"journal":{"name":"Journal of Radiation Research","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149039481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical impact of introducing automated plan checking in radiation therapy: effects on workflow efficiency, cognitive load and usability.","authors":"Kazuhiro Arai, Shohei Tanaka, Taichi Hoshino, Yushan Xiao, Wingyi Lee, Yoshiyuki Takahashi, Noriyuki Kadoya, Yoshiyuki Katsuta, Keiichi Jingu","doi":"10.1093/jrr/rrag078","DOIUrl":"https://doi.org/10.1093/jrr/rrag078","url":null,"abstract":"<p><p>As radiation therapy planning becomes increasingly complex, the risk of human error and the workload associated with plan checking have intensified for medical physicists. This study aimed to develop an automated plan check script using the Eclipse Scripting API and to quantitatively evaluate its impact on workflow efficiency, subjective operator workload and system usability in a clinical setting. A script was developed in C# to automatically verify treatment parameters, naming conventions and data consistency and to generate standardized PDF reports. Four experienced medical physicists performed plan checks on nine representative clinical cases using both conventional manual checks and script-assisted checks in a randomized order. The total time required to complete the plan check process was measured for each trial. Subjective workload was assessed using the NASA Task Load Index, and system usability was evaluated using the System Usability Scale. Script-assisted checks significantly reduced the mean plan check time compared with manual checks (418.6 ± 48.8 s vs 549.9 ± 52.5 s, P = 0.0039), corresponding to an average reduction of 131.3 s (23.9%) per case, with a maximum reduction of ~4 min in complex cases such as electron therapy. NASA Task Load Index scores demonstrated notable reductions in effort, frustration and mental demand while maintaining high performance levels. System Usability Scale results indicated high usability, learnability and operator confidence. Automated plan checking effectively improves workflow efficiency while reducing cognitive and psychological burden, which may support a more standardized quality assurance workflow in radiation therapy planning.</p>","PeriodicalId":16922,"journal":{"name":"Journal of Radiation Research","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149016967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patient stratification for dose scaling in cervical cancer: a model-based analysis using image-guided adaptive brachytherapy.","authors":"Tenyoh Suzuki, Ryo Takahashi, Hidenobu Tachibana, Shioto Oda, Takeshi Fujisawa, Masaki Nakamura, Hidehiro Hojo, Kento Tomizawa, Weishan Chang, Tetsuo Akimoto, Sadamoto Zenda","doi":"10.1093/jrr/rrag047","DOIUrl":"10.1093/jrr/rrag047","url":null,"abstract":"<p><p>The purpose of this study was to identify the characteristics of cervical cancer patients who benefit most from dose scaling (DS) using a model-based approach in image-guided adaptive brachytherapy (IGABT). We retrospectively analyzed 57 cervical cancer patients who underwent IGABT and external beam radiotherapy. Model-based DS was simulated to increase the brachytherapy dose until predefined normal tissue complication probability thresholds were reached. Clinically significant therapeutic gain was predefined as a tumor control probability (TCP) increase of greater than 3%, consistent with prior radiobiological modeling studies. Patient characteristics were compared between groups with and without significant TCP gain. Of the 53 patients in whom dose escalation was feasible, 16 (30.2%) achieved a significant TCP gain. A significant gain was strongly associated with histopathological type and magnetic resonance imaging (MRI) findings. All four patients (100%) with adeno/adenosquamous carcinoma (AdSq) achieved a significant gain, compared with only 12 of 49 (24.5%) with squamous cell carcinoma (P = 0.006). Uterine corpus invasion (UCI) on MRI was also a significant predictor of benefit (P < 0.001). Conversely, larger high-risk clinical target volume limited the potential for dose increase. AdSq cases demonstrated substantial improvement, with TCP increases after DS often exceeding 10%. Patients with poor prognostic features on MRI, specifically UCI, and those with histological AdSq may benefit most from DS in IGABT for cervical cancer. This exploratory study suggests that model-based DS shows promise for personalized treatment planning, supporting a shift from fixed-dose prescriptions toward strategies tailored to individual patient and tumor characteristics.</p>","PeriodicalId":16922,"journal":{"name":"Journal of Radiation Research","volume":" ","pages":"665-672"},"PeriodicalIF":2.1,"publicationDate":"2026-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13400573/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148396868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of percutaneous and transarterial fiducial marker placement before proton therapy for pancreatic cancer.","authors":"Jumpei Shoji, Kengo Ohta, Kazushi Suzuki, Akihiro Horibe, Motoki Hatano, Kazuma Murai, Koichiro Nakajima, Hiromitsu Iwata, Hiroyuki Ogino, Akio Hiwatashi","doi":"10.1093/jrr/rrag032","DOIUrl":"10.1093/jrr/rrag032","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to evaluate the feasibility and safety of percutaneous fiducial marker placement using a 25G needle compared with transarterial placement before proton therapy for pancreatic cancer.</p><p><strong>Materials and methods: </strong>Patients who underwent fiducial marker placement from 2013 to 2023 were retrospectively reviewed. For percutaneous placement, a 25G needle was used to place markers in or around the tumor under computed tomography (CT) guidance. For transarterial placement, a metal coil was placed as a fiducial marker in a blood vessel near the tumor using a microcatheter. Technical success was defined as the reliable use of the placed fiducial marker throughout the entire proton therapy course. Major complications were defined as grade 3 or higher. Each outcome was compared using Fisher's exact test or the Mann-Whitney U test.</p><p><strong>Results: </strong>Forty-nine and 60 patients underwent percutaneous and transarterial fiducial marker placement, respectively. The technical success rates were 89.8 and 90.0% for percutaneous and transarterial placement, respectively, with no statistically significant difference between them (P > 0.99). There were no major complications in either case. The median procedure time for percutaneous placement was significantly shorter than that for transarterial placement (3.3 vs 40.0 min; P < 0.001). The median distance between the marker and the tumor was shorter with percutaneous placement than with transarterial placement (0.0 vs 10.0 mm; P = 0.005).</p><p><strong>Conclusion: </strong>Percutaneous placement of fiducial markers for pancreatic cancer proton therapy using a 25G needle could be performed faster than transarterial placement with a high success rate.</p>","PeriodicalId":16922,"journal":{"name":"Journal of Radiation Research","volume":" ","pages":"577-583"},"PeriodicalIF":2.1,"publicationDate":"2026-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13400558/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147941506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Setting the radiological baseline: measuring natural radioactivity (226Ra, 232Th, 40K) in agricultural soils of Farta District, Ethiopia, and assessing potential health risks.","authors":"Tadesse Abate Gobaw","doi":"10.1093/jrr/rrag041","DOIUrl":"10.1093/jrr/rrag041","url":null,"abstract":"<p><p>Tracking natural radioactivity, especially from naturally occurring radioactive material (NORM), matters for public health radiation concerns. We measured agricultural soils from Ethiopia's Farta District using high-purity germanium gamma-ray spectrometry. There's something people often miss: international guidelines like 1 mSv per year or 370 Bq/kg (for radium equivalent activity, Raeq) aren't strict regulatory cutoffs, just broad screening tools. They help flag areas worth a closer look but don't mean there's a problem if background levels are naturally higher. Here's what we found: 226Ra ranged from 12 to 342 Bq/kg, 232Th from 10 to 321 Bq/kg and 40 K from 65 to 671 Bq/kg. The averages are 144 ± 83, 141 ± 81 and 340 ± 182 Bq/kg for each, in order. Average Raeq was 370 ± 200 Bq/kg, which matches the usual international screening number, although some spots went above it. Factoring in an agricultural occupancy rate of 0.4 (because farmers spend more time outdoors), the average annual effective dose (AED) hit 0.41 mSv. If you assume a more general lifestyle with less outdoor exposure (occupancy 0.2), the AED drops to 0.20 mSv. So, you can really see how behavior shapes exposure. A number of samples went above the recommended marks for the internal hazard index (H_in) and annual gonadal dose equivalent. But again, these are just screening flags; they don't mean there's an immediate health threat. This work builds a strong baseline for the region. It gives future projects like environmental monitoring, food-chain tracking, radon measurements, or health studies a solid place to start, especially in a geologically unique area like Ethiopia's Farta District.</p>","PeriodicalId":16922,"journal":{"name":"Journal of Radiation Research","volume":" ","pages":"498-515"},"PeriodicalIF":2.1,"publicationDate":"2026-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13400575/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148163522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"DVH parameters and gastrointestinal/genitourinary toxicities in moderate hypofractionated salvage radiotherapy after radical prostatectomy.","authors":"Manami Otsuka, Hiroshi Taguchi, Ryusei Ashida, Hideki Minatogawa, Takuya Moriguchi, Norikata Takada, Satoru Maruyama, Toru Harabayashi, Noriaki Nishiyama","doi":"10.1093/jrr/rrag045","DOIUrl":"10.1093/jrr/rrag045","url":null,"abstract":"<p><p>This study aimed to evaluate the relationships between dose-volume histogram (DVH) parameters and gastrointestinal (GI) and genitourinary toxicity in patients who underwent moderate hypofractionated salvage radiotherapy after radical prostatectomy. We retrospectively reviewed patients who received moderate hypofractionated salvage radiotherapy (65 Gy in 26 fractions, four fractions per week) between 2013 and 2022. DVH parameters of the rectum, anal canal, whole bladder, bladder neck, and bladder trigone were assessed in relation to toxicity. Optimal cut-off values were determined using receiver operating characteristic curve analysis. Ninety-two patients were included, with a median follow-up of 5.2 years. Grade ≥ 2 acute rectal bleeding, acute anal pain, late rectal bleeding, and grade ≥ 1 late hematuria occurred in 13%, 24%, 14%, and 33% of patients, respectively. Acute GI toxicity was associated with low-to-moderate doses to the anal canal, whereas late rectal bleeding was associated with moderate-to-high doses to the rectum. In multivariable analysis, anal canal V20Gy and hypertension were independent predictors of acute rectal bleeding, and rectum V60Gy and acute rectal bleeding were independently associated with late rectal bleeding. These findings may contribute to establishing DVH thresholds that facilitate dose optimization in moderate hypofractionated salvage radiotherapy after radical prostatectomy.</p>","PeriodicalId":16922,"journal":{"name":"Journal of Radiation Research","volume":" ","pages":"656-664"},"PeriodicalIF":2.1,"publicationDate":"2026-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13400562/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148405058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Safety of carbon-ion radiotherapy for prostate cancer after rectal surgery: a single-institution retrospective study.","authors":"Tomoki Yamaguchi, Atsushi Okato, Masaru Wakatsuki, Kosei Miura, Hirokazu Makishima, Mio Nakajima, Tomokazu Sazuka, Shinichi Sakamoto, Kayoko Ohnishi, Tomohiko Ichikawa, Hitoshi Ishikawa","doi":"10.1093/jrr/rrag038","DOIUrl":"10.1093/jrr/rrag038","url":null,"abstract":"<p><p>Carbon-ion radiotherapy (C-ion RT) is effective in treating prostate cancer. However, the safety of this therapy in patients with a history of rectal surgery remains unclear. This study aimed to confirm the feasibility and efficacy of C-ion RT in patients with prostate cancer after rectal surgery. This study comprised 33 consecutive patients with prostate cancer who underwent C-ion RT at our institute from October 1995 to May 2024 with a history of rectal surgery for their colorectal cancers. The prescribed doses were 63.0 Gy [relative biological effectiveness (RBE)] in 20 fractions (fr), 57.6 Gy (RBE) /16 fr, and 51.6 Gy (RBE) or 54.0 Gy (RBE) /12 fr. The Common Terminology Criteria for Adverse Events, version 5.0, was used to assess toxicity. Risk factors for rectal bleeding, including patient and treatment characteristics, and dosimetric parameters were statistically analyzed. The median patient age and observation period were 70 years and 53.1 months, respectively. Late grade 1 and 2 gastrointestinal toxicities were observed in six (18.2%) and one (3.0%) patients, respectively. Late grade 1 gastrointestinal toxicities included rectal bleeding, and late grade 2 gastrointestinal toxicities included faecal incontinence. The development of late rectal bleeding was significantly associated with the duration from surgery to radiation (P = 0.040), especially <5 years (P = 0.011), and rectal Dmean (P = 0.018). C-ion RT is safe for patients with prostate cancer after rectal surgery, and its toxicity is manageable. A shorter time to radiation from rectal surgery, especially <5 years, and rectal Dmean are risk factors for late rectal bleeding.</p>","PeriodicalId":16922,"journal":{"name":"Journal of Radiation Research","volume":" ","pages":"618-625"},"PeriodicalIF":2.1,"publicationDate":"2026-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13400570/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147964102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancement of antioxidant function in various organs in mice using combined thermal and radon inhalation treatment.","authors":"Shogo Miyanaga, Ayumi Tanaka, Reiju Takenaka, Shota Naoe, Shuna Goto, Mitsuki Nagano, Kotaro Tano, Norie Kanzaki, Akihiro Sakoda, Kiyonori Yamaoka, Takahiro Kataoka","doi":"10.1093/jrr/rrag049","DOIUrl":"10.1093/jrr/rrag049","url":null,"abstract":"<p><p>Enhancing antioxidant function is a key strategy for preventing and treating oxidative stress-related diseases. Radon inhalation and thermal treatment (TT) increase the levels of antioxidant enzymes, such as superoxide dismutase (SOD). The positive effects of this combination on pain-related diseases have been reported; however, few studies have elucidated the underlying mechanisms. In this study, we examined the enhancement of antioxidant function in various organs of mice subjected to combined TT and radon inhalation. The mice were placed in an incubator once daily for 40 min at 38.5 ± 0.5°C and treated for 1, 3 and 7 days. The mice then inhaled radon at a concentration of 2000 Bq/m3 for 24 h. The characteristic changes in antioxidant function following combined TT and radon inhalation could be categorized into four groups: (i) increased antioxidant function in the brain and colon; (ii) increased or decreased antioxidant function, as observed in the kidney; (iii) decreased antioxidant function, such as in the lungs and (iv) no changes, such as in the small intestine, spleen, pancreas, heart, liver and stomach. Additionally, SOD may be the antioxidant enzyme most sensitive to combined TT and radon treatment. Collectively, the combined treatment may be the most effective in activating antioxidative functions in the brain and colon. This study provides new insights into the effects of combined TT and radon inhalation.</p>","PeriodicalId":16922,"journal":{"name":"Journal of Radiation Research","volume":" ","pages":"538-549"},"PeriodicalIF":2.1,"publicationDate":"2026-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13400557/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148430679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}