Journal of Radiation Research最新文献_第10页

The Japanese nationwide cohort data of proton beam therapy for liver oligometastasis in breast cancer patients. 日本全国范围内质子束治疗乳腺癌患者肝脏寡转移的队列数据。

IF 2 4区医学

Journal of Radiation Research Pub Date : 2024-03-22 DOI: 10.1093/jrr/rrad106

Hisashi Yamaguchi, Nobuyoshi Fukumitsu, Haruko Numajiri, Hiroyuki Ogino, Tomoaki Okimoto, Takashi Ogino, Motohisa Suzuki, Shigeyuki Murayama

{"title":"The Japanese nationwide cohort data of proton beam therapy for liver oligometastasis in breast cancer patients.","authors":"Hisashi Yamaguchi, Nobuyoshi Fukumitsu, Haruko Numajiri, Hiroyuki Ogino, Tomoaki Okimoto, Takashi Ogino, Motohisa Suzuki, Shigeyuki Murayama","doi":"10.1093/jrr/rrad106","DOIUrl":"10.1093/jrr/rrad106","url":null,"abstract":"A nationwide multicenter cohort study on particle therapy was launched by the Japanese Society for Radiation Oncology in Japan in May 2016. We analyzed the outcome of proton beam therapy (PBT) for liver oligometastasis in breast cancers. Cases in which PBT was performed at all Japanese proton therapy facilities between May 2016 and February 2019 were enrolled. The patients were selected based on the following criteria: the primary cancer was controlled, liver recurrence without extrahepatic tumors and no more than three liver lesions. Fourteen females, with a median age of 57 years (range, 44-73) and 22 lesions, were included. The median lesion size, fraction (fr) size and biological effective dose were 44 (20-130) mm, 6.6 (2-8) gray (Gy) (relative biological effectiveness)/fr and 109.6 (52.7-115.2) Gy, respectively. The median follow-up period was 22.8 (4-54) months. The 1-, 2- and 3-year local control (LC) rates of liver metastasis from breast cancer were 100% for all. The 1-, 2- and 3-year overall survival rates were 85.7, 62.5 and 62.5%, respectively. The 1-, 2- and 3-year progression-free survival (PFS) rates were 50.0%, 33.3%, and 16.7%, respectively. The median PFS time was 16 months. Only one patient did not complete PBT due to current disease progression. One patient had Grade 3 radiation-induced dermatitis. None of the patients experienced radiation-induced liver failure during the acute or late phase. Owing to the low incidence of adverse events and the high LC rate, PBT appears to be a feasible option for liver oligometastasis in breast cancers.","PeriodicalId":16922,"journal":{"name":"Journal of Radiation Research","volume":" ","pages":"231-237"},"PeriodicalIF":2.0,"publicationDate":"2024-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10959435/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139697660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anti-radiation effect of MRN-100: a hydro-ferrate fluid, in vivo. MRN-100 的活体抗辐射效果：一种氢铁酸盐流体。

IF 2 4区医学

Journal of Radiation Research Pub Date : 2024-03-22 DOI: 10.1093/jrr/rrad095

Mamdooh Ghoneum, Nariman K Badr El-Din, Mai Alaa El-Dein

{"title":"Anti-radiation effect of MRN-100: a hydro-ferrate fluid, in vivo.","authors":"Mamdooh Ghoneum, Nariman K Badr El-Din, Mai Alaa El-Dein","doi":"10.1093/jrr/rrad095","DOIUrl":"10.1093/jrr/rrad095","url":null,"abstract":"Ionizing radiation (IR) severely harms many organs, especially the hematopoietic tissue, mandating the development of protective nutraceuticals. MRN-100, a hydro-ferrate fluid, has been shown to protect γ-radiated fish against hematopoietic tissue damage and lethality. The current study aimed to examine MRN-100's protective effect against irradiated mice and explore the mechanisms underlying its effect. Mice received a single acute, sub-lethal, 5 Gy, whole body dose of X-ray IR. MRN-100 treatment was administered daily for 2-weeks pre-irradiation until 1-week post-irradiation. Spleen and blood were analysed for oxidative stress, hematological, histological and biochemical parameters. Radiation exposure markedly decreased complete blood count (CBC) parameters including hemoglobin, hematocrit, red blood cells, platelets, white blood cells and lymphocytes, and significantly increased neutrophils. In contrast, MRN-100 supplementation to irradiated mice ameliorated all CBC parameters and protected against DNA damage in both splenic cells and serum. It also had an antioxidant effect, increasing the levels of glutathione, superoxide dismutase, catalase and total antioxidant capacity, which were otherwise decreased by irradiation. MRN-100 intake reduced the oxidative stress biomarker levels of nitric oxide, protein carbonyl, malondialdehyde, reactive oxygen species and 8-hydroxydeoxyguanosine, a marker specific to DNA damage. Furthermore, MRN-100 enhanced serum iron and reversed the radiation-induced elevations of liver enzymes. Finally, MRN-100 protected splenic tissue from irradiation as observed by histology. We conclude that MRN-100 consumption may protect against oxidative stress generated by radiation exposure, suggesting that it may be employed as an adjuvant treatment to prevent radiation's severe damage to important organs.","PeriodicalId":16922,"journal":{"name":"Journal of Radiation Research","volume":" ","pages":"145-158"},"PeriodicalIF":2.0,"publicationDate":"2024-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10959437/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139512830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Radiological imaging protection: a study on imaging dose used while planning computed tomography for external radiotherapy in Japan. 放射成像保护：日本外放射治疗计算机断层扫描规划时使用的成像剂量研究。

IF 2 4区医学

Journal of Radiation Research Pub Date : 2024-03-22 DOI: 10.1093/jrr/rrad098

Satoshi Kito, Yuhi Suda, Satoshi Tanabe, Takeshi Takizawa, Tomomasa Nagahata, Naoki Tohyama, Hiroyuki Okamoto, Takumi Kodama, Yukio Fujita, Hisayuki Miyashita, Kazuya Shinoda, Masahiko Kurooka, Hidetoshi Shimizu, Takeshi Ohno, Masataka Sakamoto

{"title":"Radiological imaging protection: a study on imaging dose used while planning computed tomography for external radiotherapy in Japan.","authors":"Satoshi Kito, Yuhi Suda, Satoshi Tanabe, Takeshi Takizawa, Tomomasa Nagahata, Naoki Tohyama, Hiroyuki Okamoto, Takumi Kodama, Yukio Fujita, Hisayuki Miyashita, Kazuya Shinoda, Masahiko Kurooka, Hidetoshi Shimizu, Takeshi Ohno, Masataka Sakamoto","doi":"10.1093/jrr/rrad098","DOIUrl":"10.1093/jrr/rrad098","url":null,"abstract":"Previous studies have primarily focused on quality of imaging in radiotherapy planning computed tomography (RTCT), with few investigations on imaging doses. To our knowledge, this is the first study aimed to investigate the imaging dose in RTCT to determine baseline data for establishing national diagnostic reference levels (DRLs) in Japanese institutions. A survey questionnaire was sent to domestic RT institutions between 10 October and 16 December 2021. The questionnaire items were volume computed tomography dose index (CTDIvol), dose-length product (DLP), and acquisition parameters, including use of auto exposure image control (AEC) or image-improving reconstruction option (IIRO) for brain stereotactic irradiation (brain STI), head and neck (HN) intensity-modulated radiotherapy (IMRT), lung stereotactic body radiotherapy (lung SBRT), breast-conserving radiotherapy (breast RT), and prostate IMRT protocols. Details on the use of motion-management techniques for lung SBRT were collected. Consequently, we collected 328 responses. The 75th percentiles of CTDIvol were 92, 33, 86, 23, and 32 mGy and those of DLP were 2805, 1301, 2416, 930, and 1158 mGy·cm for brain STI, HN IMRT, lung SBRT, breast RT, and prostate IMRT, respectively. CTDIvol and DLP values in institutions that used AEC or IIRO were lower than those without use for almost all sites. The 75th percentiles of DLP in each treatment technique for lung SBRT were 2541, 2034, 2336, and 2730 mGy·cm for free breathing, breath holding, gating technique, and real-time tumor tracking technique, respectively. Our data will help in establishing DRLs for RTCT protocols, thus reducing imaging doses in Japan.","PeriodicalId":16922,"journal":{"name":"Journal of Radiation Research","volume":" ","pages":"159-167"},"PeriodicalIF":2.0,"publicationDate":"2024-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10959444/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139048946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The potential overdose of heart and left anterior descending coronary artery region during intensity-modulated radiation therapy in patients with esophageal cancer. 食管癌患者在接受调强放射治疗时心脏和左前降支冠状动脉区域可能出现的剂量过量。

IF 2 4区医学

Journal of Radiation Research Pub Date : 2024-03-22 DOI: 10.1093/jrr/rrad100

Kenji Makita, Yasushi Hamamoto, Hiromitsu Kanzaki, Kei Nagasaki

{"title":"The potential overdose of heart and left anterior descending coronary artery region during intensity-modulated radiation therapy in patients with esophageal cancer.","authors":"Kenji Makita, Yasushi Hamamoto, Hiromitsu Kanzaki, Kei Nagasaki","doi":"10.1093/jrr/rrad100","DOIUrl":"10.1093/jrr/rrad100","url":null,"abstract":"This study aimed to investigate the changes in dose distribution in the heart and left anterior descending coronary artery region (LADR) during intensity-modulated radiation therapy (IMRT) in patients with esophageal cancer (EC) treated at our institution. The heart and LADR were delineated on the initial and off-cord boost planning computed tomography (CT) images. Cardiac volume reduction (CVR) was defined as the reduction in cardiac volume between the initial CT and off-cord boost CT at the dose of 36 Gy irradiated. The involved field IMRT plan was created based on each initial and off-cord boost CT image and was analyzed based on the relationship between CVR and heart and LADR dose-volume parameters (Heart-Dmax, Heart-Dmean, Heart-V20, Heart-V30, Heart-V40, LADR-Dmax, LADR-Dmean, LADR-V15 and LADR-V30). Forty patients with EC were investigated between January 2016 and January 2022. The median CVR ratio during radiation therapy (RT) was 5.57% (range, -7.79 to 18.26%). Simple linear regression analysis revealed significant correlations between CVR during RT and changes in the heart and LADR dose-volume parameters. Some patients (>10%) experienced severe changes in the heart and LADR dose distribution. In three cases with reduced heart volume and primary tumor mass, the changes in LADR-V15 and LADR-V30 showed outliers. In conclusion, CVR during RT correlated with an increase in the heart and LADR dose. When both CVR and tumor volume reduction are large, a potential overdose of LADR during RT should be noted in the IMRT era.","PeriodicalId":16922,"journal":{"name":"Journal of Radiation Research","volume":" ","pages":"238-243"},"PeriodicalIF":2.0,"publicationDate":"2024-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10959431/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139048947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

MHY1485 potentiates immunogenic cell death induction and anti-cancer immunity following irradiation. MHY1485 能增强辐照后的免疫原性细胞死亡诱导和抗癌免疫。

IF 2 4区医学

Journal of Radiation Research Pub Date : 2024-03-22 DOI: 10.1093/jrr/rrad107

Lue Sun, Kumi Morikawa, Yu Sogo, Yuki Sugiura

{"title":"MHY1485 potentiates immunogenic cell death induction and anti-cancer immunity following irradiation.","authors":"Lue Sun, Kumi Morikawa, Yu Sogo, Yuki Sugiura","doi":"10.1093/jrr/rrad107","DOIUrl":"10.1093/jrr/rrad107","url":null,"abstract":"Recent in vitro experiments showed that combined treatment with MHY1485, a low-molecular-weight compound, and X-ray irradiation significantly increased apoptosis and senescence in tumor cells, which was associated with oxidative stress, endoplasmic reticulum (ER) stress and p21 stabilization, compared to radiation treatment alone. However, evidence for MHY1485 treatment-mediated suppression of tumor growth in animals is still lacking. Furthermore, it has been shown that ER stress enhances immunogenic cell death (ICD) in tumor cells, as it can exert a favorable influence on the anti-cancer immune system. In the present study, we examined whether co-treatment of MHY1485 and X-ray irradiation induces ICD and in vivo tumor growth suppression using the CT26 and Lewis lung carcinoma murine tumor cell lines. We found that MHY1485 + X-ray treatment promotes ICD more effectively than X-ray treatment alone. MHY1485 suppresses tumor growth in vivo under co-treatment with X-rays and increases INF-γ, tumor necrosis factor, interleukin-2 and interleukin-12 levels in the spleen as well as the presence of CD8+ cells in the tumor. The results suggest that MHY1485 treatment leads to the conversion of irradiated tumors into effective vaccines. Thus, MHY1485 is a promising lead compound for use in combination with radiotherapy.","PeriodicalId":16922,"journal":{"name":"Journal of Radiation Research","volume":" ","pages":"205-214"},"PeriodicalIF":2.0,"publicationDate":"2024-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10959436/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139707016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Albumin-bilirubin score is a useful predictor of worsening liver reserve after stereotactic body radiation therapy in elderly Japanese patients with hepatocellular carcinoma. 白蛋白-胆红素评分是预测日本老年肝细胞癌患者接受立体定向体放射治疗后肝脏储备功能恶化的有效指标。

IF 2 4区医学

Journal of Radiation Research Pub Date : 2024-03-22 DOI: 10.1093/jrr/rrae006

Yuki Yoshino, Gen Suzuki, Hiroya Shiomi, Takuya Kimoto, Sho Seri, Hideya Yamazaki, Kei Yamada

{"title":"Albumin-bilirubin score is a useful predictor of worsening liver reserve after stereotactic body radiation therapy in elderly Japanese patients with hepatocellular carcinoma.","authors":"Yuki Yoshino, Gen Suzuki, Hiroya Shiomi, Takuya Kimoto, Sho Seri, Hideya Yamazaki, Kei Yamada","doi":"10.1093/jrr/rrae006","DOIUrl":"10.1093/jrr/rrae006","url":null,"abstract":"The prognosis of patients with hepatocellular carcinoma (HCC) is closely related to their liver reserves. The Child-Pugh (CP) score has traditionally been used to evaluate this reserve, with CP Grade B (CP score ≥ 7) associated with a higher risk of radiation-induced liver disease after stereotactic body radiation therapy (SBRT). However, the CP score has limitations, as it does not accurately assess liver reserve capacity. The albumin-bilirubin (ALBI) score has been introduced as a meticulous indicator of liver reserve for the treatment of HCC. We retrospectively evaluated the role of the ALBI score in estimating the worsening liver reserve in 42 patients with HCC treated with SBRT using CyberKnife between 2015 and 2023. The median biologically effective dose (α/β = 10 Gy) was 100 Gy. For a median follow-up duration of 17.4 months, the 1-year overall survival (OS), local control (LC) and progression-free survival (PFS) rates were 100, 98 and 62%, respectively. Worsening liver reserve was defined as an increase in the modified ALBI grade or CP score within 1 year after SBRT. Univariate and multivariate analyses showed that the baseline ALBI score (≥-2.7 vs <-2.7) was the only significantly different predictor of worsening liver reserve. The OS and LC rates after SBRT for HCC were satisfactory. However, the PFS was poor, and recurrent HCC will require additional treatment. It is clinically important to predict the liver reserve capacity after SBRT, and the baseline ALBI score is a useful predictor.","PeriodicalId":16922,"journal":{"name":"Journal of Radiation Research","volume":" ","pages":"244-250"},"PeriodicalIF":2.0,"publicationDate":"2024-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10959440/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139983140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mechanistic insights into the survival curve of HeLa cells with a short shoulder and their S phase-specific sensitivity†. 短肩 HeLa 细胞存活曲线及其 S 期特异性敏感性的机理启示†。

IF 2 4区医学

Journal of Radiation Research Pub Date : 2024-03-22 DOI: 10.1093/jrr/rrad097

Kenshi Komatsu, Hiroshi Tauchi

引用次数: 0

Cone-beam computed tomography-guided online adaptive radiotherapy for pharyngeal cancer with whole neck irradiation: dose-volume histogram analysis between adapted and scheduled plans. 锥形束计算机断层扫描引导的咽癌全颈部照射在线自适应放疗：自适应计划与预定计划的剂量-体积直方图分析。

IF 2 4区医学

Journal of Radiation Research Pub Date : 2024-03-22 DOI: 10.1093/jrr/rrad103

Takuya Uehara, Yasumasa Nishimura, Kazuki Ishikawa, Masahiro Inada, Kenji Matsumoto, Hiroshi Doi, Hajime Monzen, Yukinori Matsuo

{"title":"Cone-beam computed tomography-guided online adaptive radiotherapy for pharyngeal cancer with whole neck irradiation: dose-volume histogram analysis between adapted and scheduled plans.","authors":"Takuya Uehara, Yasumasa Nishimura, Kazuki Ishikawa, Masahiro Inada, Kenji Matsumoto, Hiroshi Doi, Hajime Monzen, Yukinori Matsuo","doi":"10.1093/jrr/rrad103","DOIUrl":"10.1093/jrr/rrad103","url":null,"abstract":"The present study aimed to evaluate whether an adapted plan with Ethos™ could be used for pharyngeal cancer. Ten patients with pharyngeal cancer who underwent chemoradiotherapy with available daily cone-beam computed tomography (CBCT) data were included. Simulated treatments were generated on the Ethos™ treatment emulator using CBCTs every four to five fractions for two plans: adapted and scheduled. The simulated treatments were divided into three groups: early (first-second week), middle (third-fourth week), and late (fifth-seventh week) periods. Dose-volume histogram parameters were compared for each period between the adapted and scheduled plans in terms of the planning target volume (PTV) (D98%, D95%, D50% and D2%), spinal cord (Dmax and D1cc), brainstem (Dmax) and ipsilateral and contralateral parotid glands (Dmedian and Dmean). The PTV D98%, D95% and D2% of the adapted plan were significantly higher than those of the scheduled plans in all periods, except for D98% in the late period. The adapted plan significantly reduced the spinal cord Dmax and D1cc compared with the scheduled plan in all periods. Ipsilateral and contralateral parotid glands Dmean of the adapted plan were lower than those of scheduled plan in the late period. In conclusion, the present study revealed that the adapted plans could maintain PTV coverage while reducing the doses to organs at risk in each period compared with scheduled plans.","PeriodicalId":16922,"journal":{"name":"Journal of Radiation Research","volume":" ","pages":"223-230"},"PeriodicalIF":2.0,"publicationDate":"2024-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10959439/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139542680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Application of a derivative of human defensin 5 to treat ionizing radiation-induced enterogenic infection. 应用人类防御素 5 的衍生物治疗电离辐射引起的肠源性感染。

IF 2 4区医学

Journal of Radiation Research Pub Date : 2024-03-22 DOI: 10.1093/jrr/rrad104

Gaomei Zhao, Yingjuan He, Yin Chen, Yiyi Jiang, Chenwenya Li, Tainong Xiong, Songling Han, Yongwu He, Jining Gao, Yongping Su, Junping Wang, Cheng Wang

{"title":"Application of a derivative of human defensin 5 to treat ionizing radiation-induced enterogenic infection.","authors":"Gaomei Zhao, Yingjuan He, Yin Chen, Yiyi Jiang, Chenwenya Li, Tainong Xiong, Songling Han, Yongwu He, Jining Gao, Yongping Su, Junping Wang, Cheng Wang","doi":"10.1093/jrr/rrad104","DOIUrl":"10.1093/jrr/rrad104","url":null,"abstract":"Enterogenic infection is a common complication for patients with radiation injury and requires efficient therapeutics in the clinic. Herein, we evaluated the promising drug candidate T7E21RHD5, which is a peptide derived from intestinal Paneth cell-secreted human defensin 5. Oral administration of this peptide alleviated the diarrhea symptoms of mice that received total abdominal irradiation (TAI, γ-ray, 12 Gy) and improved survival. Pathologic analysis revealed that T7E21RHD5 elicited an obvious mitigation of ionizing radiation (IR)-induced epithelial damage and ameliorated the reduction in the levels of claudin, zonula occluden 1 and occludin, three tight junction proteins in the ileum. Additionally, T7E21RHD5 regulated the gut microbiota in TAI mice by remodeling β diversity, manifested as a reversal of the inverted proportion of Bacteroidota to Firmicutes caused by IR. T7E21RHD5 treatment also decreased the abundance of pathogenic Escherichia-Shigella but significantly increased the levels of Alloprevotella and Prevotellaceae_NK3B31, two short-chain fatty acid-producing bacterial genera in the gut. Accordingly, the translocation of enterobacteria and lipopolysaccharide to the blood, as well as the infectious inflammatory responses in the intestine after TAI, was all suppressed by T7E21RHD5 administration. Hence, this versatile antimicrobial peptide possesses promising application prospects in the treatment of IR-induced enterogenic infection.","PeriodicalId":16922,"journal":{"name":"Journal of Radiation Research","volume":" ","pages":"194-204"},"PeriodicalIF":2.0,"publicationDate":"2024-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10959430/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139542661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluating thyroid cancer risks for nuclear workers related to the Fukushima Daiichi Nuclear Power Plant accident based on LNT theory is problematic. 根据 LNT 理论评估与福岛第一核电站事故有关的核工作人员患甲状腺癌的风险是有问题的。

IF 1.9 4区医学

Journal of Radiation Research Pub Date : 2024-03-22 DOI: 10.1093/jrr/rrae002

Bobby R Scott

引用次数: 0