Journal of Radiation Research最新文献_第10页

Current status of remote radiotherapy treatment planning in Japan: findings from a national survey†. 日本远程放射治疗计划的现状:来自全国调查的结果†。

IF 1.9 4区医学

Journal of Radiation Research Pub Date : 2024-01-19 DOI: 10.1093/jrr/rrad085

Masahide Saito, Tetsuro Tamamoto, Shohei Kawashiro, Rei Umezawa, Masaki Matsuda, Naoki Tohyama, Yoshiyuki Katsuta, Takayuki Kanai, Hikaru Nemoto, Hiroshi Onishi

{"title":"Current status of remote radiotherapy treatment planning in Japan: findings from a national survey†.","authors":"Masahide Saito, Tetsuro Tamamoto, Shohei Kawashiro, Rei Umezawa, Masaki Matsuda, Naoki Tohyama, Yoshiyuki Katsuta, Takayuki Kanai, Hikaru Nemoto, Hiroshi Onishi","doi":"10.1093/jrr/rrad085","DOIUrl":"10.1093/jrr/rrad085","url":null,"abstract":"The purpose of this study was to investigate the status of remote-radiotherapy treatment planning (RRTP) in Japan through a nationwide questionnaire survey. The survey was conducted between 29 June and 4 August 2022, at 834 facilities in Japan that were equipped with linear accelerators. The survey utilized a Google form that comprised 96 questions on facility information, information about the respondent, utilization of RRTP between facilities, usage for telework and the inclination to implement RRTPs in the respondent's facility. The survey analyzed the utilization of the RRTP system in four distinct implementation types: (i) utilization as a supportive facility, (ii) utilization as a treatment facility, (iii) utilization as a teleworker outside of the facility and (iv) utilization as a teleworker within the facility. The survey response rate was 58.4% (487 facilities responded). Among the facilities that responded, 10% (51 facilities) were implementing RRTP. 13 served as supportive facilities, 23 as treatment facilities, 17 as teleworkers outside of the facility and 5 as teleworkers within the facility. In terms of system usage between supportive and treatment facilities, 70-80% of the participants utilized the system for emergencies or as overtime work for external workers. A substantial number of facilities (38.8%) reported that they were unfamiliar with RRTP implementation. The survey showed that RRTP utilization in Japan is still limited, with a significant number of facilities unfamiliar with the technology. The study highlights the need for greater understanding and education about RRTP and financial funds of economical compensation.","PeriodicalId":16922,"journal":{"name":"Journal of Radiation Research","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10803164/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138299294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A multivariable normal tissue complication probability model for predicting radiation-induced hypothyroidism in nasopharyngeal carcinoma patients in the modern radiotherapy era. 现代放疗时代鼻咽癌放射性甲状腺功能减退的多变量正常组织并发症概率预测模型

IF 1.9 4区医学

Journal of Radiation Research Pub Date : 2024-01-19 DOI: 10.1093/jrr/rrad091

Siriporn Wongwattananard, Anussara Prayongrat, Natchalee Srimaneekarn, Anthony Hayter, Jiratchaya Sophonphan, Seksan Kiatsupaibul, Puvarith Veerabulyarith, Yothin Rakvongthai, Napat Ritlumlert, Sarin Kitpanit, Danita Kannarunimit, Chawalit Lertbutsayanukul, Chakkapong Chakkabat

{"title":"A multivariable normal tissue complication probability model for predicting radiation-induced hypothyroidism in nasopharyngeal carcinoma patients in the modern radiotherapy era.","authors":"Siriporn Wongwattananard, Anussara Prayongrat, Natchalee Srimaneekarn, Anthony Hayter, Jiratchaya Sophonphan, Seksan Kiatsupaibul, Puvarith Veerabulyarith, Yothin Rakvongthai, Napat Ritlumlert, Sarin Kitpanit, Danita Kannarunimit, Chawalit Lertbutsayanukul, Chakkapong Chakkabat","doi":"10.1093/jrr/rrad091","DOIUrl":"10.1093/jrr/rrad091","url":null,"abstract":"Radiation-induced hypothyroidism (RHT) is a common long-term complication for nasopharyngeal carcinoma (NPC) survivors. A model using clinical and dosimetric factors for predicting risk of RHT could suggest a proper dose-volume parameters for the treatment planning in an individual level. We aim to develop a multivariable normal tissue complication probability (NTCP) model for RHT in NPC patients after intensity-modulated radiotherapy or volumetric modulated arc therapy. The model was developed using retrospective clinical data and dose-volume data of the thyroid and pituitary gland based on a standard backward stepwise multivariable logistic regression analysis and was then internally validated using 10-fold cross-validation. The final NTCP model consisted of age, pretreatment thyroid-stimulating hormone and mean thyroid dose. The model performance was good with an area under the receiver operating characteristic curve of 0.749 on an internal (200 patients) and 0.812 on an external (25 patients) validation. The mean thyroid dose at ≤45 Gy was suggested for treatment plan, owing to an RHT incidence of 2% versus 61% in the >45 Gy group.","PeriodicalId":16922,"journal":{"name":"Journal of Radiation Research","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10803165/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138299292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Long-term outcomes of stimulated salivary flow and xerostomia after definitive intensity-modulated radiation therapy for patients with head and neck cancer†. 头颈癌患者明确调强放疗后刺激唾液流和口干的长期结局

IF 1.9 4区医学

Journal of Radiation Research Pub Date : 2024-01-19 DOI: 10.1093/jrr/rrad087

Shinya Hiraoka, Michio Yoshimura, Aya Nakajima, Ryota Nakashima, Takashi Mizowaki

{"title":"Long-term outcomes of stimulated salivary flow and xerostomia after definitive intensity-modulated radiation therapy for patients with head and neck cancer†.","authors":"Shinya Hiraoka, Michio Yoshimura, Aya Nakajima, Ryota Nakashima, Takashi Mizowaki","doi":"10.1093/jrr/rrad087","DOIUrl":"10.1093/jrr/rrad087","url":null,"abstract":"This retrospective study aimed to evaluate the time to recovery from xerostomia and analyze its predictors, along with long-term outcomes of stimulated salivary flow after intensity-modulated radiation therapy (IMRT) for head and neck cancer (HNC). We evaluated patients with HNC who had received IMRT with curative intent between 2012 and 2018 at our institution. The salivary recovery ratio (SRR) was defined as '(the stimulated salivary flow)/(pre-treatment salivary flow)'. The cutoff value of SRR in salivary recovery was estimated via the relationship between SRR and xerostomia grades. The salivary recovery time was defined as the time for SRR to exceed cutoff values from the end of radiotherapy. Fifty-seven patients were analyzed, with a 48-month median follow-up period of stimulated salivary flow. The cutoff value for SRR was 44.8%, and patients with a higher grade of xerostomia had a lower SRR (P < 0.001). The median salivary recovery time was 12 months. The cumulative incidence rates of salivary recovery at two and four years were 84 (95% confidence interval [CI]: 53-79) and 92% (95% CI: 82-97), respectively, and these were significantly lower in patients with a higher mean parotid gland dose, mean oral cavity dose and stimulated salivary flow per parotid gland volume. Stimulated salivary flow and xerostomia recover over a long period after radiotherapy.","PeriodicalId":16922,"journal":{"name":"Journal of Radiation Research","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10803167/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138299296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Revolutionizing radiation therapy: the role of AI in clinical practice. 革命性的放射治疗:人工智能在临床实践中的作用。

IF 1.9 4区医学

Journal of Radiation Research Pub Date : 2024-01-19 DOI: 10.1093/jrr/rrad090

Mariko Kawamura, Takeshi Kamomae, Masahiro Yanagawa, Koji Kamagata, Shohei Fujita, Daiju Ueda, Yusuke Matsui, Yasutaka Fushimi, Tomoyuki Fujioka, Taiki Nozaki, Akira Yamada, Kenji Hirata, Rintaro Ito, Noriyuki Fujima, Fuminari Tatsugami, Takeshi Nakaura, Takahiro Tsuboyama, Shinji Naganawa

{"title":"Revolutionizing radiation therapy: the role of AI in clinical practice.","authors":"Mariko Kawamura, Takeshi Kamomae, Masahiro Yanagawa, Koji Kamagata, Shohei Fujita, Daiju Ueda, Yusuke Matsui, Yasutaka Fushimi, Tomoyuki Fujioka, Taiki Nozaki, Akira Yamada, Kenji Hirata, Rintaro Ito, Noriyuki Fujima, Fuminari Tatsugami, Takeshi Nakaura, Takahiro Tsuboyama, Shinji Naganawa","doi":"10.1093/jrr/rrad090","DOIUrl":"10.1093/jrr/rrad090","url":null,"abstract":"This review provides an overview of the application of artificial intelligence (AI) in radiation therapy (RT) from a radiation oncologist's perspective. Over the years, advances in diagnostic imaging have significantly improved the efficiency and effectiveness of radiotherapy. The introduction of AI has further optimized the segmentation of tumors and organs at risk, thereby saving considerable time for radiation oncologists. AI has also been utilized in treatment planning and optimization, reducing the planning time from several days to minutes or even seconds. Knowledge-based treatment planning and deep learning techniques have been employed to produce treatment plans comparable to those generated by humans. Additionally, AI has potential applications in quality control and assurance of treatment plans, optimization of image-guided RT and monitoring of mobile tumors during treatment. Prognostic evaluation and prediction using AI have been increasingly explored, with radiomics being a prominent area of research. The future of AI in radiation oncology offers the potential to establish treatment standardization by minimizing inter-observer differences in segmentation and improving dose adequacy evaluation. RT standardization through AI may have global implications, providing world-standard treatment even in resource-limited settings. However, there are challenges in accumulating big data, including patient background information and correlating treatment plans with disease outcomes. Although challenges remain, ongoing research and the integration of AI technology hold promise for further advancements in radiation oncology.","PeriodicalId":16922,"journal":{"name":"Journal of Radiation Research","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10803173/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138299298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ultrasound-mediated delivery of Pik3cb shRNA using magnetic nanoparticles for the treatment of in-stent restenosis in a rat balloon-injured model. 使用磁性纳米颗粒超声介导的Pik3cb-shRNA递送用于治疗大鼠球囊损伤模型中的支架内再狭窄。

IF 1.9 4区医学

Journal of Radiation Research Pub Date : 2024-01-19 DOI: 10.1093/jrr/rrad083

Yuhao Wang, Miao Li, Zongxiang Sheng, Hong Ran, Jing Dong, Lingling Fang, Pingyang Zhang

{"title":"Ultrasound-mediated delivery of Pik3cb shRNA using magnetic nanoparticles for the treatment of in-stent restenosis in a rat balloon-injured model.","authors":"Yuhao Wang, Miao Li, Zongxiang Sheng, Hong Ran, Jing Dong, Lingling Fang, Pingyang Zhang","doi":"10.1093/jrr/rrad083","DOIUrl":"10.1093/jrr/rrad083","url":null,"abstract":"The aim of the present work was to examine the effect of polyethylene glycol (PEG)-coated superparamagnetic iron oxide (SPIO) nanoparticles carrying Pik3cb short hairpin RNA (shRNA) in the prevention of restenosis with the aid of ultrasound and a magnetic field. SPIO is a type of contrast agent used in medical imaging to enhance the visibility of specific tissues or organs. It consists of tiny iron oxide nanoparticles that can be targeted to specific areas of interest in the body. PEG-coated SPIO nanoparticles carrying Pik3cb shRNA (SPIO-shPik3cb) were prepared, and the particle size and zeta potential of PEG-coated SPIO nanoparticles with and without Pik3cb shRNA were examined. After a right common artery balloon-injured rat model was established, the rats were randomly divided into four groups, and the injured arteries were transfected with SPIO-shPik3cb, saline, SPIO-shcontrol and naked shRNA Pik3cb. During the treatment, each group was placed under a magnetic field and was transfected with the aid of ultrasound. Rats were sacrificed, and the tissue was harvested for analysis after 14 days. The results suggested that the mean particle size and zeta potential of SPIO-shPik3cbs were 151.45 ± 11 nm and 10 mV, respectively. SPIO-shPik3cb showed higher transfection efficiency and significantly inhibited the intimal thickening compared with naked Pik3cb shRNA in vascular smooth muscle cells (VSMCs) (*P < 0.05). Moreover, SPIO-shPik3cb could also significantly downregulate the expression of pAkt protein compared with naked Pik3cb shRNA. According to the results, SPIO-shPik3cb can remarkably inhibit the intimal thickening under a combination of magnetic field exposure and ultrasound.","PeriodicalId":16922,"journal":{"name":"Journal of Radiation Research","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10803161/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72209756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dosimetric verification of four dose calculation algorithms for spine stereotactic body radiotherapy. 脊柱立体定向放射治疗四种剂量计算算法的剂量学验证。

IF 1.9 4区医学

Journal of Radiation Research Pub Date : 2024-01-19 DOI: 10.1093/jrr/rrad086

Hideaki Hirashima, Mitsuhiro Nakamura, Kiyonao Nakamura, Yukinori Matsuo, Takashi Mizowaki

{"title":"Dosimetric verification of four dose calculation algorithms for spine stereotactic body radiotherapy.","authors":"Hideaki Hirashima, Mitsuhiro Nakamura, Kiyonao Nakamura, Yukinori Matsuo, Takashi Mizowaki","doi":"10.1093/jrr/rrad086","DOIUrl":"10.1093/jrr/rrad086","url":null,"abstract":"The applications of Type B [anisotropic analytical algorithm (AAA) and collapsed cone (CC)] and Type C [Acuros XB (AXB) and photon Monte Carlo (PMC)] dose calculation algorithms in spine stereotactic body radiotherapy (SBRT) were evaluated. Water- and bone-equivalent phantoms were combined to evaluate the percentage depth dose and dose profile. Subsequently, 48 consecutive patients with clinical spine SBRT plans were evaluated. All treatment plans were created using AXB in Eclipse. The prescription dose was 24 Gy in two fractions at a 10 MV FFF on TrueBeam. The doses were then recalculated with AAA, CC and PMC while maintaining the AXB-calculated monitor units and beam arrangement. The dose index values obtained using the four dose calculation algorithms were then compared. The AXB and PMC dose distributions agreed with the bone-equivalent phantom measurements (within ±2.0%); the AAA and CC values were higher than those in the bone-equivalent phantom region. For the spine SBRT plans, PMC, AAA and CC were overestimated compared with AXB in terms of the near minimum and maximum doses of the target and organ at risk, respectively; the mean dose difference was within 4.2%, which is equivalent with within 1 Gy. The phantom study showed that the results from AXB and PMC agreed with the measurements within ±2.0%. However, the mean dose difference ranged from 0.5 to 1 Gy in the spine SBRT planning study when the dose calculation algorithms changed. Users should incorporate a clinical introduction that includes an awareness of these differences.","PeriodicalId":16922,"journal":{"name":"Journal of Radiation Research","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10803157/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138299295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

VMAT with DIBH in hypofractionated radiotherapy for left-sided breast cancer after breast-conserving surgery: results of a non-inferiority clinical study 保乳手术后左侧乳腺癌低分量放疗中的 VMAT 和 DIBH：非劣效性临床研究结果

IF 2 4区医学

Journal of Radiation Research Pub Date : 2023-12-13 DOI: 10.1093/jrr/rrad096

Keiichi Jingu, Kengo Ito, Kiyokazu Sato, Rei Umezawa, Takaya Yamamoto, Noriyoshi Takahashi, Yu Suzuki, Keita Kishida, So Omata, Hinako Harada, Yasuhiro Seki, Nanae Chiba, Noriyuki Kadoya

{"title":"VMAT with DIBH in hypofractionated radiotherapy for left-sided breast cancer after breast-conserving surgery: results of a non-inferiority clinical study","authors":"Keiichi Jingu, Kengo Ito, Kiyokazu Sato, Rei Umezawa, Takaya Yamamoto, Noriyoshi Takahashi, Yu Suzuki, Keita Kishida, So Omata, Hinako Harada, Yasuhiro Seki, Nanae Chiba, Noriyuki Kadoya","doi":"10.1093/jrr/rrad096","DOIUrl":"https://doi.org/10.1093/jrr/rrad096","url":null,"abstract":"The purpose of this study was to show the safety of volumetric modulated arc therapy (VMAT) with deep inspiration breath-hold (DIBH) in hypofractionated radiotherapy for left-sided breast cancer after breast-conserving surgery in a clinical setting. Twenty-five Japanese women, aged 20–59 years, who were enrolled in this prospective non-inferiority study received VMAT under the condition of DIBH with 42.4 Gy/16 fractions for whole-breast irradiation (WBI) ± boost irradiation for the tumor bed to show the non-inferiority of VMAT with DIBH to conventional fractionated WBI with free breathing. The primary endpoint was the rate of occurrence of radiation dermatitis of Grade 3 or higher or pneumonitis of Grade 2 or higher within 6 months after the start of radiotherapy. This study was registered with UMIN00004321. All of the enrolled patients completed the planned radiotherapy without interruption. The evaluation of adverse events showed that three patients (12.0%) had Grade 2 radiation dermatitis. There was no other Grade 2 adverse event and there was no patient with an adverse event of Grade 3 or higher. Those results confirmed our hypothesis that the experimental treatment method is non-inferior compared with our historical results. There was no patient with locoregional recurrence or metastases. In conclusion, VMAT under the condition of DIBH in hypofractionated radiotherapy for left-sided breast cancer after breast-conserving surgery can be performed safely in a clinical setting.","PeriodicalId":16922,"journal":{"name":"Journal of Radiation Research","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2023-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138690767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Japanese nationwide cohort data of proton beam therapy for liver oligometastasis in esophagogastric cancer patients. 质子束治疗食管胃癌患者肝少转移的日本全国队列数据。

IF 2 4区医学

Journal of Radiation Research Pub Date : 2023-11-21 DOI: 10.1093/jrr/rrad066

Hisashi Yamaguchi, Nobuyoshi Fukumitsu, Haruko Numajiri, Hiroyuki Ogino, Norio Katoh, Tomoaki Okimoto, Motohisa Suzuki, Hideyuki Sakurai

{"title":"The Japanese nationwide cohort data of proton beam therapy for liver oligometastasis in esophagogastric cancer patients.","authors":"Hisashi Yamaguchi, Nobuyoshi Fukumitsu, Haruko Numajiri, Hiroyuki Ogino, Norio Katoh, Tomoaki Okimoto, Motohisa Suzuki, Hideyuki Sakurai","doi":"10.1093/jrr/rrad066","DOIUrl":"10.1093/jrr/rrad066","url":null,"abstract":"A nationwide multicenter cohort study on particle therapy was launched by the Japanese Society for Radiation Oncology in Japan in May 2016. We analyzed the outcome of proton beam therapy (PBT) for liver oligometastasis of esophagogastric cancers. Cases in which PBT was performed at all PBT facilities in Japan between May 2016 and February 2019 were enrolled. The patients were selected based on the following criteria: controlled primary cancer, liver recurrence without extrahepatic tumors and no more than three liver lesions. Twenty-two males and two females with a median age of 69 (range, 52-80) years and 35 lesions were included. This study included 6 patients with esophageal and 18 patients with gastric cancer. The median lesion size, fraction size and biological effective dose (BED)10 were 32 (7-104) mm, 3.8 gray (relative biological effect)/fractions (Gy (RBE)/fr) (2-8 Gy (RBE)/fr) and 96.9 (88.8-115.2) Gy, respectively. The median follow-up period was 18 (4-47) months. The 1-, 2- and 3-year overall survival (OS) rates were 75, 51.8 and 45.3%, respectively, and the median OS was 25.3 months. The 1-, 2- and 3-year cumulative local recurrence (LR) rates were 3, 6 and 6%, respectively. Patients' age (P < 0.01), performance status (P = 0.017) and tumor size (P = 0.024) were significant OS-related factors. No Grade 3 or higher adverse events (AEs) were observed. Owing to the low incidence of AEs and the low LR cumulative incidence, PBT is a feasible option for liver oligometastasis of esophagogastric cancers.","PeriodicalId":16922,"journal":{"name":"Journal of Radiation Research","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2023-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10665303/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10211147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Radiation-induced gastric injury during radiotherapy: molecular mechanisms and clinical treatment. 放射治疗中放射性胃损伤的分子机制及临床治疗。

IF 2 4区医学

Journal of Radiation Research Pub Date : 2023-11-21 DOI: 10.1093/jrr/rrad071

Guangxia Chen, Zuxiang Yu, Yuehua Zhang, Shiyu Liu, Chong Chen, Shuyu Zhang

引用次数: 0

Acute hematologic toxicity of radiation therapy - a comprehensive analysis and predictive nomogram. 放射治疗的急性血液学毒性——综合分析和预测列线图。

IF 2 4区医学

Journal of Radiation Research Pub Date : 2023-11-21 DOI: 10.1093/jrr/rrad069

Kazuya Takeda, Rei Umezawa, Takaya Yamamoto, Noriyoshi Takahashi, Yu Suzuki, Keita Kishida, So Omata, Keiichi Jingu

{"title":"Acute hematologic toxicity of radiation therapy - a comprehensive analysis and predictive nomogram.","authors":"Kazuya Takeda, Rei Umezawa, Takaya Yamamoto, Noriyoshi Takahashi, Yu Suzuki, Keita Kishida, So Omata, Keiichi Jingu","doi":"10.1093/jrr/rrad069","DOIUrl":"10.1093/jrr/rrad069","url":null,"abstract":"To investigate radiation-induced cytopenia and establish predictive nomograms for hematological toxicity, we reviewed 3786 patients aged 18 or older who received radiation monotherapy between 2010 and 2021 for non-hematologic malignancies. We collected data on patient background, treatment content and hematologic toxicities for 12 weeks after the start of radiotherapy. The patients were randomly divided into training and test groups in 7:3 ratio. In the training group, we conducted ordered logistic regression analysis to identify predictive factors for neutropenia, lymphocytopenia, anemia and thrombocytopenia. Nomograms to predict Grade 2-4 cytopenia were generated and validated in the test group. Grade 3 or higher hematologic toxicities were observed in 9.7, 44.6, 8.3 and 3.1% of patients with neutropenia, lymphocytopenia, anemia and thrombocytopenia, respectively. We identified six factors for neutropenia grade, nine for lymphocytopenia grade and six for anemia grade with statistical significance. In the analysis of thrombocytopenia, the statistical model did not converge because of a small number of events. Nomograms were generated using factors with high predictive power. In evaluating the nomograms, we found high area under the receiver operating characteristic curve values (neutropenia; 0.75-0.85, lymphopenia; 0.89-0.91 and anemia; 0.85-0.86) in predicting Grade 2-4 cytopenia in the test group. We established predictive nomograms for neutropenia, leukocytopenia and anemia and demonstrated high reproducibility when validated in an independent cohort of patients.","PeriodicalId":16922,"journal":{"name":"Journal of Radiation Research","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2023-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10665302/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41141795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0