Journal of Radiation Research最新文献_第9页

Enhanced induction of abnormal telomere FISH signals in response to oxidative DNA damage. 氧化 DNA 损伤会增强端粒 FISH 异常信号的诱导。

IF 2 4区医学

Journal of Radiation Research Pub Date : 2024-03-22 DOI: 10.1093/jrr/rrad102

Yoshimi Sakamoto, Kazunori Shiraishi, Seiji Kodama

{"title":"Enhanced induction of abnormal telomere FISH signals in response to oxidative DNA damage.","authors":"Yoshimi Sakamoto, Kazunori Shiraishi, Seiji Kodama","doi":"10.1093/jrr/rrad102","DOIUrl":"10.1093/jrr/rrad102","url":null,"abstract":"Telomere dysfunction induces chromosomal instability, which is a driving force in the development of cancers. To examine X-irradiation's effect on telomere integrity, we investigated X-ray-induced abnormalities in telomere signals detected by fluorescence in situ hybridization (telomere FISH) in mouse embryo fibroblast cells. The abnormalities were categorized as either extra telomere signals (ETSs) or loss of telomere signals (LTSs). The results indicated that low doses (0.3-0.5 Gy) of X-rays significantly induced ETS but not LTS and that ETS induction was saturated at doses above 0.5 Gy. In addition, treatment with hydrogen peroxide also induced ETS but not LTS. To clarify the involvement of radicals in inducing ETS, we examined the effect of ascorbic acid (AsA) on telomere FISH signals and found that pre-treatment with AsA (5 mM, 2 h), but not post-treatment, significantly suppressed the induction of ETS by X-irradiation. Importantly, neither pre- nor post-treatment with AsA affected X-ray-induced chromosome aberrations. These results suggest that oxidative DNA damage induced by radicals is involved in the induction of ETS. Furthermore, combined treatment with aphidicolin, a DNA replication inhibitor, elevated the induction of ETS by X-irradiation. This observation suggests that DNA replication stress, potentially triggered by oxidative DNA lesions within telomeres, may contribute to the induction of ETS resulting from X-irradiation. Based on these results, we propose that ETS is a sensitive biological marker of oxidative DNA damage in telomere structures.","PeriodicalId":16922,"journal":{"name":"Journal of Radiation Research","volume":" ","pages":"187-193"},"PeriodicalIF":2.0,"publicationDate":"2024-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10959432/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139087324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of external dose estimates using different retrospective dosimetry methods in the settlements located near Semipalatinsk Nuclear Test Site, Republic of Kazakhstan. 在哈萨克斯坦共和国塞米巴拉金斯克核试验场附近居民点使用不同回顾性剂量学方法进行的外剂量估计比较。

IF 1.9 4区医学

Journal of Radiation Research Pub Date : 2024-01-19 DOI: 10.1093/jrr/rrad082

Valeriy Stepanenko, Sergey Shinkarev, Andrey Kaprin, Kazbek Apsalikov, Sergey Ivanov, Peter Shegay, Evgenia Ostroumova, Ausrele Kesminiene, Alexandra Lipikhina, Viktoria Bogacheva, Kassym Zhumadilov, Masayoshi Yamamoto, Aya Sakaguchi, Satoru Endo, Nariaki Fujimoto, Bernd Grosche, Vladimir Iatsenko, Alla Androsova, Zukhra Apsalikova, Noriyuki Kawano, Masaharu Hoshi

{"title":"Comparison of external dose estimates using different retrospective dosimetry methods in the settlements located near Semipalatinsk Nuclear Test Site, Republic of Kazakhstan.","authors":"Valeriy Stepanenko, Sergey Shinkarev, Andrey Kaprin, Kazbek Apsalikov, Sergey Ivanov, Peter Shegay, Evgenia Ostroumova, Ausrele Kesminiene, Alexandra Lipikhina, Viktoria Bogacheva, Kassym Zhumadilov, Masayoshi Yamamoto, Aya Sakaguchi, Satoru Endo, Nariaki Fujimoto, Bernd Grosche, Vladimir Iatsenko, Alla Androsova, Zukhra Apsalikova, Noriyuki Kawano, Masaharu Hoshi","doi":"10.1093/jrr/rrad082","DOIUrl":"10.1093/jrr/rrad082","url":null,"abstract":"For correct assessment of health risks after low-dose irradiation, calculation of radiation exposure estimates is crucial. To verify the calculated absorbed doses, instrumental methods of retrospective dosimetry are used. We compared calculated and instrumental-based estimates of external absorbed doses in the residents of Dolon, Mostik and Cheremushki villages, Kazakhstan, affected by the first nuclear weapon test performed at the Semipalatinsk Nuclear Test Site (SNTS) on August 29, 1949. The 'instrumental' doses were retrospectively estimated using the Luminescence Retrospective Dosimetry (LRD) and Electron Spin Resonance (ESR) methods. Correlation between the calculated individual cumulative external absorbed whole-body doses based on typical input data and ESR-based individual doses in the same people was strong (r = 0.782). It was even stronger between the calculated doses based on individual questionnaires' input data and the ESR-based doses (r = 0.940). Application of the LRD method is useful for validation of the calculated settlement-average cumulated external absorbed dose to air. Reconstruction of external exposure can be supplemented with the data from later measurements of soil contamination with long-lived radionuclides, such as, 137Cs. Our results show the reliability of the calculational method used for the retrospective assessment of individual external doses.","PeriodicalId":16922,"journal":{"name":"Journal of Radiation Research","volume":" ","pages":"36-46"},"PeriodicalIF":1.9,"publicationDate":"2024-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10803160/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138047218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Real-time tumor-tracking radiotherapy with SyncTraX for primary liver tumors requiring isocenter shift†. SyncTraX实时肿瘤跟踪放疗治疗原发性肝肿瘤的等中心移位

IF 1.9 4区医学

Journal of Radiation Research Pub Date : 2024-01-19 DOI: 10.1093/jrr/rrad088

Yusuke Uchinami, Naoki Miyamoto, Daisuke Abo, Ryo Morita, Koji Ogawa, Tatsuhiko Kakisaka, Ryusuke Suzuki, Tomohiko Miyazaki, Hiroshi Taguchi, Norio Katoh, Hidefumi Aoyama

{"title":"Real-time tumor-tracking radiotherapy with SyncTraX for primary liver tumors requiring isocenter shift†.","authors":"Yusuke Uchinami, Naoki Miyamoto, Daisuke Abo, Ryo Morita, Koji Ogawa, Tatsuhiko Kakisaka, Ryusuke Suzuki, Tomohiko Miyazaki, Hiroshi Taguchi, Norio Katoh, Hidefumi Aoyama","doi":"10.1093/jrr/rrad088","DOIUrl":"10.1093/jrr/rrad088","url":null,"abstract":"The SyncTraX series enables real-time tumor-tracking radiotherapy through the real-time recognition of a fiducial marker using fluoroscopic images. In this system, the isocenter should be located within approximately 5-7.5 cm from the marker, depending on the version, owing to the limited field of view. If the marker is placed away from the tumor, the isocenter should be shifted toward the marker. This study aimed to investigate stereotactic body radiotherapy (SBRT) outcomes of primary liver tumors treated with SyncTraX in cases where the isocenter was shifted marginally or outside the planning target volume (PTV). Twelve patients with 13 liver tumors were included in the analysis. Their isocenter was shifted toward the marker and was placed marginally or outside the PTV. The prescribed doses were generally 40 Gy in four fractions or 48 Gy in eight fractions. The overall survival (OS) and local control (LC) rates were calculated using the Kaplan-Meier method. All patients completed the scheduled SBRT. The median distance between the fiducial marker and PTV centroid was 56.0 (interquartile range [IQR]: 52.7-66.7) mm. By shifting the isocenter toward the marker, the median distance between the marker and isocenter decreased to 34.0 (IQR: 33.4-39.7) mm. With a median follow-up period of 25.3 (range: 6.9-70.0) months, the 2-year OS and LC rates were 100.0% (95% confidence interval: 100-100). An isocenter shift makes SBRT with SyncTraX feasible in cases where the fiducial marker is distant from the tumor.","PeriodicalId":16922,"journal":{"name":"Journal of Radiation Research","volume":" ","pages":"92-99"},"PeriodicalIF":1.9,"publicationDate":"2024-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10803168/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138299297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Daily fraction dose-adjusted radiotherapy policy to avoid prolonging the overall treatment time for early glottic squamous cell carcinoma: a single-institutional retrospective study. 每日剂量调整放疗策略避免延长早期声门鳞状细胞癌的总治疗时间:一项单机构回顾性研究。

IF 1.9 4区医学

Journal of Radiation Research Pub Date : 2024-01-19 DOI: 10.1093/jrr/rrad080

Yasuhiro Dekura, Koichi Yasuda, Hideki Minatogawa, Yusuke Uchinami, Nayuta Tsushima, Takayoshi Suzuki, Satoshi Kano, Takashi Mori, Kentaro Nishioka, Keiji Kobashi, Norio Katoh, Akihiro Homma, Hidefumi Aoyama

{"title":"Daily fraction dose-adjusted radiotherapy policy to avoid prolonging the overall treatment time for early glottic squamous cell carcinoma: a single-institutional retrospective study.","authors":"Yasuhiro Dekura, Koichi Yasuda, Hideki Minatogawa, Yusuke Uchinami, Nayuta Tsushima, Takayoshi Suzuki, Satoshi Kano, Takashi Mori, Kentaro Nishioka, Keiji Kobashi, Norio Katoh, Akihiro Homma, Hidefumi Aoyama","doi":"10.1093/jrr/rrad080","DOIUrl":"10.1093/jrr/rrad080","url":null,"abstract":"The objective of this study was to determine the outcomes of radical radiotherapy for early glottic squamous cell carcinoma (EGSCC) with the policy of increasing the fraction size during radiotherapy when the overall treatment time (OTT) was expected to be prolonged. Patients diagnosed with clinical T1-2N0M0 EGSCC, who were treated with radical radiotherapy between 2008 and 2019 at Hokkaido University Hospital, were included. Patients received 66 Gy in 33 fractions for T1 disease and 70 Gy in 35 fractions for T2 disease as our standard regimen (usual group [UG]). If the OTT was expected to extend for >1 week, the dose fraction size was increased from 2.0 to 2.5 Gy from the beginning or during radiotherapy (adjusted group [AG]). At this time, we performed a statistical analysis between UG and AG. In total, 116 patients were identified, and the treatment schedules of 29 patients were adjusted. The median follow-up was 60.9 months. In the T1 group, the cumulative 5-year local failure rate was 12.0% in the AG and 15.4% in the UG, and in the T2 group, the rate was 40.7% in the AG and 25.3% in the UG. There were no significant differences between the AG and UG. Similarly, no significant differences were observed for overall survival and progression-free survival rates. Our single-institutional retrospective analysis of EGSCC patients suggested that a method of adjusting the radiotherapy schedule to increase fraction size from the beginning or during the course may be effective in maintaining treatment outcomes.","PeriodicalId":16922,"journal":{"name":"Journal of Radiation Research","volume":" ","pages":"63-70"},"PeriodicalIF":1.9,"publicationDate":"2024-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10803170/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89718746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gamma-irradiated Aspergillus conidia show a growth curve with a reproductive death phase. γ射线照射的曲霉菌分生孢子显示出具有生殖死亡阶段的生长曲线。

IF 1.9 4区医学

Journal of Radiation Research Pub Date : 2024-01-19 DOI: 10.1093/jrr/rrad081

Shigetoshi Horikiri, Mami Harada, Ryoko Asada, Tetsuaki Tsuchido, Masakazu Furuta

{"title":"Gamma-irradiated Aspergillus conidia show a growth curve with a reproductive death phase.","authors":"Shigetoshi Horikiri, Mami Harada, Ryoko Asada, Tetsuaki Tsuchido, Masakazu Furuta","doi":"10.1093/jrr/rrad081","DOIUrl":"10.1093/jrr/rrad081","url":null,"abstract":"In this study, we evaluated the effects of gamma irradiation on the germination of Aspergillus conidia and mycelial growth using microscopy and predictive microbiological modeling methods. A dose of 0.4 kGy reduced the germination rate by 20% compared to the untreated control, indicating interphase death due to the high radiation dose. The number of colonies formed (5.5%) was lower than the germination rate (69%), suggesting that most colonies died after germination. Microscopic observations revealed that mycelial elongation ceased completely in the middle of the growth phase, indicating reproductive death. The growth curves of irradiated conidia exhibited a delayed change in the growth pattern, and a decrease in slope during the early stages of germination and growth at low densities. A modified logistic model, which is a general purpose growth model that allows for the evaluation of subpopulations, was used to fit the experimental growth curves. Dose-dependent waveform changes may reflect the dynamics of the subpopulations during germination and growth. These methods revealed the occurrence of two cell death populations resulting from gamma irradiation of fungal conidia and contribute to the understanding of irradiation-induced cell death in fungi.","PeriodicalId":16922,"journal":{"name":"Journal of Radiation Research","volume":" ","pages":"28-35"},"PeriodicalIF":1.9,"publicationDate":"2024-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10803171/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72209755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

MTDH enhances radiosensitivity of head and neck squamous cell carcinoma by promoting ferroptosis based on a prognostic signature. MTDH通过促进基于预后特征的铁下垂来增强头颈部鳞状细胞癌的放射敏感性。

IF 1.9 4区医学

Journal of Radiation Research Pub Date : 2024-01-19 DOI: 10.1093/jrr/rrad074

Xiang Cao, Yizhi Ge, Zhenyu Yan, Xinyu Hu, Fanyu Peng, Yujie Zhang, Xia He, Dan Zong

{"title":"MTDH enhances radiosensitivity of head and neck squamous cell carcinoma by promoting ferroptosis based on a prognostic signature.","authors":"Xiang Cao, Yizhi Ge, Zhenyu Yan, Xinyu Hu, Fanyu Peng, Yujie Zhang, Xia He, Dan Zong","doi":"10.1093/jrr/rrad074","DOIUrl":"10.1093/jrr/rrad074","url":null,"abstract":"Ionizing radiation (IR) induces ferroptosis in head and neck squamous cell carcinoma (HNSCC). But, it remains unclear whether ferroptosis affects the prognosis of HNSCC patients after receiving radiotherapy. This study aims to develop a ferroptosis signature to predict the radiosensitivity and prognosis of HNSCC. Ferroptosis-related genes, clinical data and RNA expression profiles were obtained from the FerrDb database, The Cancer Genome Atlas and GEO database. Prognostic genes were identified by random survival forest, univariate Cox regression, Kaplan-Meier and ROC analyses. Principal component analysis, multivariate Cox regression, nomogram and DCA analyses were conducted to estimate its predictive ability. Functional enrichment and immune-related analyses were performed to explore potential biological mechanisms and tumor immune microenvironment. The effect of the hub gene on ferroptosis and radiosensitivity was verified using flow cytometry, quantitative real-time PCR and clonogenic survival assay. We constructed a ferroptosis-related signature, including IL6, NCF2, metadherin (MTDH) and CBS. We classified patients into high-risk (HRisk) and low-risk groups according to the risk scores. The risk score was confirmed to be an independent predictor for overall survival (OS). Combining the clinical stage with the risk score, we established a predictive nomogram for OS. Furthermore, pathways related to tumorigenesis and tumor immune suppression were mainly enriched in HRisk. MTDH was verified to have a potent effect on IR-induced ferroptosis and consequently promoted radiosensitivity. We constructed a ferroptosis-related signature to predict radiosensitivity and OS in HNSCC patients. MTDH was identified as a promising therapeutic target in radioresistant HNSCC patients.","PeriodicalId":16922,"journal":{"name":"Journal of Radiation Research","volume":" ","pages":"10-27"},"PeriodicalIF":1.9,"publicationDate":"2024-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10803166/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138047219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development of local-power-free, remote α-particle detection using optical fibers. 基于光纤的局部无电源、远程α粒子检测技术的发展。

IF 1.9 4区医学

Journal of Radiation Research Pub Date : 2024-01-19 DOI: 10.1093/jrr/rrad092

Kent B Pfeifer, Thomas M Weber, James E Martin

{"title":"Development of local-power-free, remote α-particle detection using optical fibers.","authors":"Kent B Pfeifer, Thomas M Weber, James E Martin","doi":"10.1093/jrr/rrad092","DOIUrl":"10.1093/jrr/rrad092","url":null,"abstract":"We demonstrate the application of fluorescence optical fiber coupled to a telecom grade fiber as a sensor for alpha particles using alpha-specific ZnS(Ag) scintillation materials whose wavelength is down-shifted into a low-loss region of the telecom grade fiber transmission band. Telecom-grade fiber optics offer a solution for sensing alpha radiation in deep repositories and cask storage for radioactive materials due to the stability of SiO2 under normal environmental conditions and its relative radiation hardness at low radiation doses. Long-term nuclear waste storage facilities require sensors for the detection of leakage of radioactive materials that are maintenance-free, do not require power and can survive with no 'wear out' mechanisms for decades. By accomplishing the wavelength transformation, we maximize efficiencies in the detection of α-particles and signal transport and can detect alpha scintillation at distances on the order of >1 km with a sensor that is ~3% efficient and can be easily scaled as a sensor array. This paper describes the construction and testing of the sensor including manufacture of the controlled thickness films, verification of the wavelength shift from 450 to 620 nm and optimization of the sensitivity as a function of thickness. We also model the relative sensitivity of the film as a function of film thickness, and we demonstrate a signal-to-noise ratio of 10 at a range of greater than 1 km.","PeriodicalId":16922,"journal":{"name":"Journal of Radiation Research","volume":" ","pages":"136-143"},"PeriodicalIF":1.9,"publicationDate":"2024-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10803159/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138460607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical outcomes of scalp or face angiosarcoma treatment with intensity-modulated radiotherapy: a multicenter study. 用调强放疗治疗头皮或面部血管肉瘤的临床结果:一项多中心研究

IF 1.9 4区医学

Journal of Radiation Research Pub Date : 2024-01-19 DOI: 10.1093/jrr/rrad089

Takahiro Iwai, Toshiyuki Imagumbai, Shinya Hiraoka, Takahiro Kishi, Shun Okabayashi, Ryo Ashida, Takamasa Mitsuyoshi, Yukinori Matsuo, Takashi Ishigaki, Takashi Mizowaki, Masaki Kokubo

{"title":"Clinical outcomes of scalp or face angiosarcoma treatment with intensity-modulated radiotherapy: a multicenter study.","authors":"Takahiro Iwai, Toshiyuki Imagumbai, Shinya Hiraoka, Takahiro Kishi, Shun Okabayashi, Ryo Ashida, Takamasa Mitsuyoshi, Yukinori Matsuo, Takashi Ishigaki, Takashi Mizowaki, Masaki Kokubo","doi":"10.1093/jrr/rrad089","DOIUrl":"10.1093/jrr/rrad089","url":null,"abstract":"Combined modality therapy, including radiotherapy (RT), is a common treatment for scalp or face angiosarcoma. Although intensity-modulated radiotherapy (IMRT) can deliver homogeneous doses to the scalp or face, clinical data are limited. This multicenter study aimed to evaluate scalp or face angiosarcoma treated with definitive or post-operative IMRT. We retrospectively analyzed data from patients who received IMRT for scalp or face angiosarcoma at three institutions between January 2015 and March 2020. Local control (LC) rate, overall survival (OS), progression-free survival (PFS), recurrence patterns and toxicity were evaluated. Fifteen patients underwent IMRT during the study period. Definitive RT was performed on 10 patients and post-operative RT was performed on 5 patients. The 1-year LC rate was 85.7% (95% confidence interval [CI], 53.9-96.2%). The 1-year OS and PFS rates were 66.7% (95% CI, 37.5-84.6%) and 53.3% (95% CI, 26.3%-74.4%), respectively. Univariate analysis revealed that a clinical target volume over 500 cm3 was associated with poor LC. Distant metastasis was the most common recurrence pattern. All patients experienced Grade 2 or 3 radiation dermatitis, and five patients experienced grade ≥ 3 skin ulceration. One patient who underwent maintenance therapy with pazopanib developed Grade 5 skin ulceration. Fisher's exact test showed that post-operative RT was significantly associated with an increased risk of skin ulceration of grade ≥ 3. These results demonstrate that IMRT is a feasible and effective treatment for scalp or face angiosarcoma, although skin ulceration of grade ≥ 3 is a common adverse event in patients who receive post-operative RT.","PeriodicalId":16922,"journal":{"name":"Journal of Radiation Research","volume":" ","pages":"78-86"},"PeriodicalIF":1.9,"publicationDate":"2024-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10803163/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138299293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Role of microbiota in radiation-induced small-bowel damage. 微生物群在辐射诱发的小肠损伤中的作用。

IF 1.9 4区医学

Journal of Radiation Research Pub Date : 2024-01-19 DOI: 10.1093/jrr/rrad084

Yi-Fan Chen, Sung-Chou Li, Eng-Yen Huang

{"title":"Role of microbiota in radiation-induced small-bowel damage.","authors":"Yi-Fan Chen, Sung-Chou Li, Eng-Yen Huang","doi":"10.1093/jrr/rrad084","DOIUrl":"10.1093/jrr/rrad084","url":null,"abstract":"Radiation-induced gastrointestinal damage is a common acute radiation syndrome. Previous studies have highlighted that Galectin-1 and Interleukin-6 (IL-6) are associated with flaking of small intestinal villi and intestinal radioresistance. Therefore, our goal is to study whether gut bacteria regulated by galectin-1 or IL-6 can mitigate radiation-induced small intestine damage. In this study, differences between galectin-1, sgp130-regulated and wild-type (WT) mice were analyzed by microbiome array. The effects of the Firmicutes/Bacteroidetes (F/B) ratio and the proportion of bacterial distribution at the phylum level were observed after 18 Gy whole abdomen radiation. Fecal microbiota transplantation was used to implant radioresistant gut flora into WT mice, and the number of viable small intestinal crypt foci was observed by immunohistochemistry. Fecal transplantation from galectin-1 knockout and sgp130 transgenic mice, with higher radiation resistance, into WT mice significantly increased the number of surviving small intestinal crypts. This radiation resistance, generated through gene regulation, was not affected by the F/B ratio. We initially found that the small intestinal villi of WT mice receiving radioresistant mouse fecal bacteria demonstrated better repair outcomes after radiation exposure. These results indicate the need for a focus on the identification and application of superior radioresistant bacterial strains. In our laboratory, we will further investigate specific radioresistant bacterial strains to alleviate acute side effects of radiation therapy to improve the patients' immune ability and postoperative quality of life.","PeriodicalId":16922,"journal":{"name":"Journal of Radiation Research","volume":" ","pages":"55-62"},"PeriodicalIF":1.9,"publicationDate":"2024-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10803162/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138299299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An investigation into the impact of volumetric rescanning and fractionation treatment on dose homogeneity in liver cancer proton therapy. 体积重扫和分割治疗对肝癌质子治疗剂量均匀性影响的研究。

IF 1.9 4区医学

Journal of Radiation Research Pub Date : 2024-01-19 DOI: 10.1093/jrr/rrad093

Pei-Yi Lee, Bing-Shen Huang, Shen-Hao Lee, Tsz-Yui Chan, Eric Yen, Tsair-Fwu Lee, I-Chun Cho

{"title":"An investigation into the impact of volumetric rescanning and fractionation treatment on dose homogeneity in liver cancer proton therapy.","authors":"Pei-Yi Lee, Bing-Shen Huang, Shen-Hao Lee, Tsz-Yui Chan, Eric Yen, Tsair-Fwu Lee, I-Chun Cho","doi":"10.1093/jrr/rrad093","DOIUrl":"10.1093/jrr/rrad093","url":null,"abstract":"The Pencil Beam Scanning (PBS) technique in modern particle therapy offers a highly conformal dose distribution but poses challenges due to the interplay effect, an interaction between respiration-induced organ movement and PBS. This study evaluates the effectiveness of different volumetric rescanning strategies in mitigating this effect in liver cancer proton therapy. We used a Geant4-based Monte Carlo simulation toolkit, 'TOPAS,' and an image registration toolbox, 'Elastix,' to calculate 4D dose distributions from 5 patients' four-dimensional computed tomography (4DCT). We analyzed the homogeneity index (HI) value of the Clinical Tumor Volume (CTV) at different rescan numbers and treatment times. Our results indicate that dose homogeneity stabilizes at a low point after a week of treatment, implying that both rescanning and fractionation treatments help mitigate the interplay effect. Notably, an increase in the number of rescans doesn't significantly reduce the mean dose to normal tissue but effectively prevents high localized doses to tissue adjacent to the CTV. Rescanning techniques, based on statistical averaging, require no extra equipment or patient cooperation, making them widely accessible. However, the number of rescans, tumor location, diaphragm movement, and treatment fractionation significantly influence their effectiveness. Therefore, deciding the number of rescans should involve considering the number of beams, treatment fraction size, and total delivery time to avoid unnecessary treatment extension without significant clinical benefits. The results showed that 2-3 rescans are more clinically suitable for liver cancer patients undergoing proton therapy.","PeriodicalId":16922,"journal":{"name":"Journal of Radiation Research","volume":" ","pages":"100-108"},"PeriodicalIF":1.9,"publicationDate":"2024-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10803156/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138460606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0