Journal of Radiation Research最新文献

{"title":"Proton beam therapy for external auditory canal and middle ear cancers.","authors":"Masanori Machida, Takashi Ono, Koki Ando, Rei Nishikawa, Yuntao Dai, Takuya Tominaga, Yusuke Azami, Yoshiaki Takagawa, Motohisa Suzuki, Ichiro Seto, Kanako Takayama, Tatsuhiko Nakasato, Yasuhiro Kikuchi, Masao Murakami","doi":"10.1093/jrr/rrag024","DOIUrl":"10.1093/jrr/rrag024","url":null,"abstract":"<p><p>Few studies have evaluated the efficacy of proton beam therapy (PBT) for external auditory canal cancer (EACC) or middle ear cancer (MEC). Therefore, the present study aimed to evaluate the efficacy and toxicity of PBT for EACC and MEC. Between December 2009 and August 2018, 15 patients (seven males and eight females) underwent PBT for EACC or MEC. The median patient age was 64 years (range: 40-82 years). Ten patients had EACC, and five patients had MEC. PBT was administered using the passive scattering method. The median total dose of the BED10 was 88.8 Gy relative biological effectiveness (RBE) (range = 85.6-99.3 Gy [RBE]), administered in 2 Gy fractions (EQD2) (α/β = 10). Chemotherapy was conducted in 14 patients, systemic chemotherapy in five and intra-arterial infusion chemotherapy in nine. The median follow-up period for all patients was 60 months (range: 7-136 months). The 3-year overall survival, local control and progression free survival rates were 65%, 66.7% and 53.3%, respectively. Four patients had grade 3 hearing impairment owing to late toxicity. However, these patients had hearing impairment before treatment as well. No grade 4 or higher late toxicity was observed during the follow-up period. PBT is an effective treatment for EACC and MEC with tolerable toxicity, including in the setting of combined chemotherapy.</p>","PeriodicalId":16922,"journal":{"name":"Journal of Radiation Research","volume":" ","pages":"444-452"},"PeriodicalIF":2.1,"publicationDate":"2026-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13202307/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147775048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"BMSCs alleviate inflammation and inhibit apoptosis in radiation pneumonitis treatment by modulating the NF-κB/NLRP3 signaling pathway.","authors":"Yiwei Song, Yuxin Wen, Huaqing Zhai, Na Zhang, Xu Tong","doi":"10.1093/jrr/rrag029","DOIUrl":"10.1093/jrr/rrag029","url":null,"abstract":"<p><p>Radiation pneumonitis (RP) is a severe consequence of thoracic radiation, and its pathophysiology is tightly linked to NLRP3 inflammasome-mediated hyperinflammatory reactions. The nuclear factor κB (NF-κB) signaling system, which regulates NLRP3, could be a potential therapeutic target. This study explores how bone marrow-derived mesenchymal stem cells (BMSCs) can treat RP via modifying the NF-κB/NLRP3 signaling pathway. BMSCs treatment significantly reduced inflammatory infiltration in rat lung tissue and decreased inflammatory cytokine release. Mechanistically, by inhibiting the NF-κB/NLRP3 signaling axis, BMSCs consequently reduce the secretion of key pro-inflammatory mediators, including IL-1β, IL-18, and TNF-α. Additionally, BMSCs suppressed apoptosis by downregulating inflammasome formation, achieving therapeutic effects against RP. BMSCs block NF-κB/NLRP3 signaling, reducing inflammasome production. They treat RP by inhibiting inflammasomes and suppressing apoptosis. This strategy is a novel therapy option for RP management and clinical prevention.</p>","PeriodicalId":16922,"journal":{"name":"Journal of Radiation Research","volume":" ","pages":"453-466"},"PeriodicalIF":2.1,"publicationDate":"2026-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13202319/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147775028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A comment on: 'Impact of off-center diagonal profile depth pairing on gamma pass rates in portal dosimetry'.","authors":"Shyam Sundar Sah, Abhishek Kumbhalwar","doi":"10.1093/jrr/rraf090","DOIUrl":"10.1093/jrr/rraf090","url":null,"abstract":"","PeriodicalId":16922,"journal":{"name":"Journal of Radiation Research","volume":" ","pages":"483-484"},"PeriodicalIF":2.1,"publicationDate":"2026-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13202322/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147592721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Feasibility of retrieval-augmented generation for large language models with Japanese input in radiotherapy.","authors":"Yoshiyuki Takahashi, Noriyuki Kadoya, Kazuhiro Arai, Hikaru Tanno, Shohei Tanaka, Yoshiyuki Katsuta, Taichi Hoshino, Hinako Harada, So Omata, Takaya Yamamoto, Rei Umezawa, Keisuke Yasui, Naoki Hayashi, Keiichi Jingu","doi":"10.1093/jrr/rrag019","DOIUrl":"10.1093/jrr/rrag019","url":null,"abstract":"<p><p>Large language models (LLMs) have recently gained attention for their potential. However, concerns remain regarding their reliability due to limitations such as hallucinations and insufficient domain-specific knowledge. Retrieval-augmented generation (RAG) has emerged as a promising approach, enabling LLMs to reference external knowledge sources and generate accurate outputs. We aimed to clarify the potential of RAG-enhanced LLMs with Japanese input in the field of radiotherapy. This was assessed by evaluating performance on three certification examinations in Japan: the Japanese Medical Physicist Examination, the Japanese Board Examination for Radiologists, and the Japanese Board Examination for Radiation Oncologists. In this study, we constructed a RAG system named Rad-Hub, consisting of a Japanese Radiotherapy Knowledge Database (JRKD) and a retrieval framework built on Microsoft Azure. The JRKD was populated with 32 Japanese radiotherapy textbooks and clinical guidelines. We assessed its utility by inputting all multiple-choice questions from the three examinations into ChatGPT-4o, both with and without Rad-Hub, and recording the answers. They were then compared with reference answers determined by experienced medical physicists and radiation oncologists. Rad-Hub improved accuracy across all examinations. Accuracy increased from 77.0% ± 2.6% to 84.6% ± 1.5% in the Medical Physicist examination, from 74.9% ± 2.0% to 82.1% ± 1.1% in the Radiologist examination, and from 55.6% ± 4.4% to 71.7% ± 4.5% in the Radiation Oncologist examination. Performance gains ranged from 7.2% to 16.1%. These findings highlight the potential of RAG-enhanced LLMs, particularly ChatGPT-4o with Rad-Hub, for integration into radiotherapy applications, such as educational and clinical decision assistance.</p>","PeriodicalId":16922,"journal":{"name":"Journal of Radiation Research","volume":" ","pages":"420-429"},"PeriodicalIF":2.1,"publicationDate":"2026-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13202343/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147863917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Salvage stereotactic body radiotherapy for post-prostatectomy recurrence: are we almost there?","authors":"Zhe Chen, Van Ton Tran, Masaki Matsuda, Tomoko Akita, Kan Marino, Takafumi Komiyama, Hiroshi Onishi","doi":"10.1093/jrr/rrag006","DOIUrl":"10.1093/jrr/rrag006","url":null,"abstract":"<p><p>The use of hypofractionated radiotherapy (HFRT) after prostatectomy has expanded because of its radiobiological advantages and its potential to reduce treatment burden. Stereotactic body radiotherapy (SBRT), an even more condensed treatment approach, has recently emerged as a possible salvage option for men with biochemical recurrence, although its role remains investigational. To summarize current evidence, we performed a narrative review of published and ongoing studies evaluating moderate HFRT and SBRT for prostate bed salvage radiotherapy, drawing from MEDLINE, Embase, Cochrane CENTRAL, and ClinicalTrials.gov through May 2025. Across the available literature, moderate HFRT using 2.5-3.0 Gy per fraction over 15-28 fractions has shown favorable tumor control with generally acceptable safety, though some studies report increased late genitourinary toxicity with higher per-fraction doses or wide treatment margins. The phase III NRG-GU003 trial demonstrated non-inferiority of HFRT compared with conventional radiotherapy using patient-reported outcomes, supporting its clinical validity. Early SBRT experiences, often using 30-34 Gy in five fractions, have shown grade ≥ 2 genitourinary toxicity in up to approximately 29% of patients, while gastrointestinal toxicity has typically remained low. However, follow-up is short, and long-term safety remains uncertain. Although conventionally fractionated salvage radiotherapy remains the standard of care, current evidence supports moderate HFRT as an accepted alternative to conventional fractionation, whereas postoperative SBRT may be feasible in selected patients. Given limited long-term safety data and the potential for late toxicities to emerge many years after treatment, SBRT should remain investigational until results from ongoing trials become available.</p>","PeriodicalId":16922,"journal":{"name":"Journal of Radiation Research","volume":" ","pages":"161-169"},"PeriodicalIF":2.1,"publicationDate":"2026-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13019129/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147284098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cost-effectiveness analysis of intensity modulated radiation therapy versus robot-assisted radical prostatectomy for patients with low-risk prostate cancer in Japan.","authors":"Ataru Igarashi, Keiichi Jingu, Kaoru Ito, Ritsuko Koba, David W Lee","doi":"10.1093/jrr/rrag008","DOIUrl":"10.1093/jrr/rrag008","url":null,"abstract":"<p><p>This study evaluated the cost-effectiveness of hypofractionated intensity-modulated radiation therapy delivered in 20 fractions (IMRT-20) compared with robot-assisted radical prostatectomy (RARP) for patients with localized low-risk prostate cancer in Japan. A state-transition Markov model was developed from the Japanese healthcare system, using Japanese-specific cost data. Clinical probabilities, adverse event rates and health utility values were primarily derived from international sources, including the ProtecT trial, with extensive sensitivity and scenario analyses to address parameter uncertainty. The base-case analysis compared IMRT-20 and RARP. Scenario analyses included conventional fractionated IMRT (IMRT-38) versus RARP, as well as IMRT-20 versus RARP excluding the utility decrement associated with sexual dysfunction to explore preference-sensitive outcomes. Model outputs included quality-adjusted life-years (QALYs), incremental cost-effectiveness ratios (ICERs) and incremental net monetary benefit (INMB). In the base-case analysis, IMRT-20 yielded a modest QALY gain (0.1164) at slightly higher costs compared with RARP, resulting in an ICER of JPY 143 685 per QALY, well below the Japanese willingness-to-pay threshold of JPY 5 000 000 per QALY. Probabilistic sensitivity analysis showed that IMRT-20 was cost effective in 78.1% of simulations. IMRT-38 was less cost effective because of longer treatment duration and higher resource utilization (ICER JPY 3 317 380 per QALY), although it remained below the threshold. When the disutility of sexual dysfunction was excluded, IMRT-20 was dominated by RARP; however, INMB analysis indicated that IMRT-20 became economically favorable when the disutility exceeded 20%. Overall, IMRT-20 represents a clinically and economically efficient definitive treatment strategy for localized low-risk prostate cancer in Japan, supporting value-based cancer care.</p>","PeriodicalId":16922,"journal":{"name":"Journal of Radiation Research","volume":" ","pages":"266-275"},"PeriodicalIF":2.1,"publicationDate":"2026-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13019139/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147365342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Competitive cell transplantation in rat mammary tissue and its use for radiation-induced cell competition and tumor clonality assays.","authors":"Kento Nagata, Yukiko Nishimura-Yano, Ayaka Hosoki, Ken-Ichi Kudo, Kazuhiro Daino, Mayumi Nishimura, Tatsuhiko Imaoka","doi":"10.1093/jrr/rrag007","DOIUrl":"10.1093/jrr/rrag007","url":null,"abstract":"<p><p>Competitive transplantation of cells expressing distinct fluorescent proteins is an attractive method for assessing cell competition and tumor clonality, albeit its use has been limited to mouse models. Rat mammary cancer is an alternative model to mice due to its similarity to human breast cancer. This study aims to implement competitive transplantation in the context of radiation biology of the rat mammary gland and to provide a detailed protocol on key techniques. Dissociated mammary cells were obtained from wild-type and transgenic rats expressing either green (EGFP) or red (Discosoma sp. red fluorescent protein [DsRed]) fluorescent protein. The cells were exposed to γ rays or left untreated, mixed at a specific ratio and then transplanted into the cleared fat pads of wild-type or double transgenic rats. We evaluated the expression of fluorescent proteins in epithelial outgrowths using confocal imaging of cleared tissues or on histological sections. Transplanting transgenic cells into wild-type recipients induced inflammation and rejection of the donor cells. Conversely, transplanting into double transgenics resulted in successful repopulation and observation of the fluorescent markers. A competitive assay between irradiated EGFP-expressing cells and unirradiated DsRed-expressing cells revealed that radiation exposure (4 Gy) did not affect repopulating ability, despite the theoretical sensitivity of the assay, suggesting the absence of strong competition between these cells. Analysis of tumors revealed the polyclonal nature of adenomas that developed in recipients exposed to radiation or 1-methyl-1-nitrosourea. Thus, this study developed a method to track cells in the rat mammary gland that is useful in radiation biology.</p>","PeriodicalId":16922,"journal":{"name":"Journal of Radiation Research","volume":" ","pages":"308-317"},"PeriodicalIF":2.1,"publicationDate":"2026-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13019143/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147283975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"First clinical implementation of dynamic tumor-tracking volumetric modulated arc therapy with a gimbal-mounted linac: short delivery time and high precision.","authors":"Noriko Kishi, Mitsuhiro Nakamura, Hideaki Hirashima, Takanori Adachi, Masahiro Yoneyama, Kohei Kawata, Yukako Kishigami, Takashi Ogata, Takashi Murakami, Yusuke Iizuka, Hiroshi Seno, Takashi Mizowaki","doi":"10.1093/jrr/rraf093","DOIUrl":"10.1093/jrr/rraf093","url":null,"abstract":"<p><p>Dynamic tumor tracking (DTT) is an effective respiratory motion management strategy for thoracic and abdominal tumors and enables treatment delivery under free breathing using gimbal-mounted linac, without requiring breath-holding. To date, however, clinical implementations have used three-dimensional conformal radiotherapy (3D-CRT) or fixed-field intensity-modulated radiotherapy (IMRT), and integration with volumetric modulated arc therapy (VMAT) has been anticipated to shorten treatment time while improving dose distribution. This short communication reports the first clinical implementation of stereotactic body radiotherapy with DTT-VMAT using a novel gimbal-mounted linac. Planned treatment using DTT-VMAT for liver tumor over five treatment days was delivered successfully, with a mean treatment time of 23.2 min (range, 12-33 min), shorter than previously reported gimbal-based DTT with 3D-CRT or fixed-field IMRT. The average 3D tracking error was 2.4 ± 1.8 mm overall, comprising 0.3 ± 1.0 mm laterally, -1.5 ± 2.2 mm longitudinally and - 0.1 ± 1.0 mm vertically, maintaining tracking performance comparable to earlier systems. No updates to the four-dimensional model were required during beam delivery. This introduction of novel gimbaled-based DTT-VMAT approach is advantageous among available respiratory motion management techniques, as it shortens treatment time, mitigates baseline drift and improves patient compliance.</p>","PeriodicalId":16922,"journal":{"name":"Journal of Radiation Research","volume":" ","pages":"303-307"},"PeriodicalIF":2.1,"publicationDate":"2026-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13019128/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147365352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Time-dependent 53BP1 foci kinetics in X-irradiated human hair follicle dermal papilla cells.","authors":"Daisuke Hanamiya, Reo Etani, Mitsuaki Ojima","doi":"10.1093/jrr/rrag005","DOIUrl":"10.1093/jrr/rrag005","url":null,"abstract":"<p><p>We investigated the feasibility of a biological dosimetry method using human hair follicle dermal papilla cells (HFDPCs). Cultured HFDPCs were X-irradiated at doses of 50-20 000 mGy, and 53BP1 foci were analyzed up to 96 h post-irradiation to assess DNA double-strand break repair kinetics and dose-response relationships. Up to 5 h post-irradiation, 53BP1 foci increased in a significant dose-dependent manner from 50 to 1000 mGy. By 24 h, the foci count at 50 mGy returned to background levels, whereas dose dependence persisted at higher doses. Notably, analysis of the focus size revealed that the proportion of large foci (diameter ≥ 1 μm) significantly increased at doses ≥ 3000 mGy at 24 h. At 96 h post-irradiation, while total focus counts showed limited discrimination, large-foci assessment maintained significant sensitivity for doses as low as 500 mGy). These findings demonstrate that 53BP1 focus counting in HFDPCs allows for dose estimation from 50 mGy at 5 h, while focus size analysis enhances the accuracy for threshold-based estimation of doses ≥ 500 mGy up to 96 h. This study provides foundational data demonstrating the potential of HFDPCs for biological dosimetry and medical triage, warranting further validation using intact hair samples.</p>","PeriodicalId":16922,"journal":{"name":"Journal of Radiation Research","volume":" ","pages":"201-209"},"PeriodicalIF":2.1,"publicationDate":"2026-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13019137/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147290298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Structure-dependent reactive oxygen species generation by scintillator-free X-ray-activated porphyrins: insights into charge effects and internal conversion quantum yield.","authors":"Shuhei Aramaki, Shigetoshi Okazaki, Qianqing Ji, Maxime Dubail, Tsuge Shogo, Chi Zhang, Wenxin Li, Kiichi Kaminaga, Hitoshi Ishiwata, Ryuji Igarashi, Ryuichi Yada, Masataka Sakamoto, Kohei Wakabayashi, Kenta Konishi, Kosuke Shimizu, Tomoaki Kahyo, Mitsutoshi Setou, Katsumasa Nakamura","doi":"10.1093/jrr/rrag011","DOIUrl":"10.1093/jrr/rrag011","url":null,"abstract":"<p><p>Radiodynamic therapy enables treatment of deep-seated tumors but typically requires scintillator nanoparticles with associated toxicity concerns. While porphyrin photosensitizers (PS) have been shown to enhance reactive oxygen species (ROS) generation under X-ray irradiation without scintillators, the molecular features governing this effect remain unclear. Here, we systematically examined structure-activity relationships of nine porphyrin derivatives to elucidate the design principles for scintillator-free radiosensitizers. Molecular charge critically influenced ROS modulation: anionic tetrakis (4-carboxyphenyl) porphyrin showed the highest efficacy with approximately 7-fold enhancement over X-ray alone, whereas cationic tetra (N-methyl-4-pyridyl) porphyrin suppressed ROS below control levels. Notably, heavy-atom coordination yielded structure-dependent effects rather than uniform enhancement, distinguishing this process from conventional photodynamic therapy. Using complementary ROS probes, we found that X-ray-mediated ROS generation produces predominantly superoxide and hydrogen peroxide rather than singlet oxygen, suggesting electron transfer rather than energy transfer as the operative pathway. Dose-response analysis demonstrated that ROS generation scales linearly with radiation dose, indicating no saturation within the therapeutic window. Validation with clinically relevant PS showed that Visudyne and protoporphyrin IX-both bearing anionic carboxylate groups-were active. However, the inactivity of anionic but rigid rose bengal suggests that electrostatic properties alone are insufficient. These findings suggest that along with molecular charge, conformational flexibility-potentially facilitating internal conversion from high-energy excited states-represents a key design parameter for scintillator-free radiosensitizers. This approach offers a simplified, biocompatible formulation strategy for deep-tissue cancer therapy without relying on heavy-metal nanoscintillators.</p>","PeriodicalId":16922,"journal":{"name":"Journal of Radiation Research","volume":" ","pages":"210-220"},"PeriodicalIF":2.1,"publicationDate":"2026-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13019140/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147463570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}