Journal of Radiation Research最新文献_第8页

The potential overdose of heart and left anterior descending coronary artery region during intensity-modulated radiation therapy in patients with esophageal cancer. 食管癌患者在接受调强放射治疗时心脏和左前降支冠状动脉区域可能出现的剂量过量。

IF 2 4区医学

Journal of Radiation Research Pub Date : 2024-03-22 DOI: 10.1093/jrr/rrad100

Kenji Makita, Yasushi Hamamoto, Hiromitsu Kanzaki, Kei Nagasaki

{"title":"The potential overdose of heart and left anterior descending coronary artery region during intensity-modulated radiation therapy in patients with esophageal cancer.","authors":"Kenji Makita, Yasushi Hamamoto, Hiromitsu Kanzaki, Kei Nagasaki","doi":"10.1093/jrr/rrad100","DOIUrl":"10.1093/jrr/rrad100","url":null,"abstract":"This study aimed to investigate the changes in dose distribution in the heart and left anterior descending coronary artery region (LADR) during intensity-modulated radiation therapy (IMRT) in patients with esophageal cancer (EC) treated at our institution. The heart and LADR were delineated on the initial and off-cord boost planning computed tomography (CT) images. Cardiac volume reduction (CVR) was defined as the reduction in cardiac volume between the initial CT and off-cord boost CT at the dose of 36 Gy irradiated. The involved field IMRT plan was created based on each initial and off-cord boost CT image and was analyzed based on the relationship between CVR and heart and LADR dose-volume parameters (Heart-Dmax, Heart-Dmean, Heart-V20, Heart-V30, Heart-V40, LADR-Dmax, LADR-Dmean, LADR-V15 and LADR-V30). Forty patients with EC were investigated between January 2016 and January 2022. The median CVR ratio during radiation therapy (RT) was 5.57% (range, -7.79 to 18.26%). Simple linear regression analysis revealed significant correlations between CVR during RT and changes in the heart and LADR dose-volume parameters. Some patients (>10%) experienced severe changes in the heart and LADR dose distribution. In three cases with reduced heart volume and primary tumor mass, the changes in LADR-V15 and LADR-V30 showed outliers. In conclusion, CVR during RT correlated with an increase in the heart and LADR dose. When both CVR and tumor volume reduction are large, a potential overdose of LADR during RT should be noted in the IMRT era.","PeriodicalId":16922,"journal":{"name":"Journal of Radiation Research","volume":" ","pages":"238-243"},"PeriodicalIF":2.0,"publicationDate":"2024-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10959431/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139048947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

MHY1485 potentiates immunogenic cell death induction and anti-cancer immunity following irradiation. MHY1485 能增强辐照后的免疫原性细胞死亡诱导和抗癌免疫。

IF 2 4区医学

Journal of Radiation Research Pub Date : 2024-03-22 DOI: 10.1093/jrr/rrad107

Lue Sun, Kumi Morikawa, Yu Sogo, Yuki Sugiura

{"title":"MHY1485 potentiates immunogenic cell death induction and anti-cancer immunity following irradiation.","authors":"Lue Sun, Kumi Morikawa, Yu Sogo, Yuki Sugiura","doi":"10.1093/jrr/rrad107","DOIUrl":"10.1093/jrr/rrad107","url":null,"abstract":"Recent in vitro experiments showed that combined treatment with MHY1485, a low-molecular-weight compound, and X-ray irradiation significantly increased apoptosis and senescence in tumor cells, which was associated with oxidative stress, endoplasmic reticulum (ER) stress and p21 stabilization, compared to radiation treatment alone. However, evidence for MHY1485 treatment-mediated suppression of tumor growth in animals is still lacking. Furthermore, it has been shown that ER stress enhances immunogenic cell death (ICD) in tumor cells, as it can exert a favorable influence on the anti-cancer immune system. In the present study, we examined whether co-treatment of MHY1485 and X-ray irradiation induces ICD and in vivo tumor growth suppression using the CT26 and Lewis lung carcinoma murine tumor cell lines. We found that MHY1485 + X-ray treatment promotes ICD more effectively than X-ray treatment alone. MHY1485 suppresses tumor growth in vivo under co-treatment with X-rays and increases INF-γ, tumor necrosis factor, interleukin-2 and interleukin-12 levels in the spleen as well as the presence of CD8+ cells in the tumor. The results suggest that MHY1485 treatment leads to the conversion of irradiated tumors into effective vaccines. Thus, MHY1485 is a promising lead compound for use in combination with radiotherapy.","PeriodicalId":16922,"journal":{"name":"Journal of Radiation Research","volume":" ","pages":"205-214"},"PeriodicalIF":2.0,"publicationDate":"2024-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10959436/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139707016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Albumin-bilirubin score is a useful predictor of worsening liver reserve after stereotactic body radiation therapy in elderly Japanese patients with hepatocellular carcinoma. 白蛋白-胆红素评分是预测日本老年肝细胞癌患者接受立体定向体放射治疗后肝脏储备功能恶化的有效指标。

IF 2 4区医学

Journal of Radiation Research Pub Date : 2024-03-22 DOI: 10.1093/jrr/rrae006

Yuki Yoshino, Gen Suzuki, Hiroya Shiomi, Takuya Kimoto, Sho Seri, Hideya Yamazaki, Kei Yamada

{"title":"Albumin-bilirubin score is a useful predictor of worsening liver reserve after stereotactic body radiation therapy in elderly Japanese patients with hepatocellular carcinoma.","authors":"Yuki Yoshino, Gen Suzuki, Hiroya Shiomi, Takuya Kimoto, Sho Seri, Hideya Yamazaki, Kei Yamada","doi":"10.1093/jrr/rrae006","DOIUrl":"10.1093/jrr/rrae006","url":null,"abstract":"The prognosis of patients with hepatocellular carcinoma (HCC) is closely related to their liver reserves. The Child-Pugh (CP) score has traditionally been used to evaluate this reserve, with CP Grade B (CP score ≥ 7) associated with a higher risk of radiation-induced liver disease after stereotactic body radiation therapy (SBRT). However, the CP score has limitations, as it does not accurately assess liver reserve capacity. The albumin-bilirubin (ALBI) score has been introduced as a meticulous indicator of liver reserve for the treatment of HCC. We retrospectively evaluated the role of the ALBI score in estimating the worsening liver reserve in 42 patients with HCC treated with SBRT using CyberKnife between 2015 and 2023. The median biologically effective dose (α/β = 10 Gy) was 100 Gy. For a median follow-up duration of 17.4 months, the 1-year overall survival (OS), local control (LC) and progression-free survival (PFS) rates were 100, 98 and 62%, respectively. Worsening liver reserve was defined as an increase in the modified ALBI grade or CP score within 1 year after SBRT. Univariate and multivariate analyses showed that the baseline ALBI score (≥-2.7 vs <-2.7) was the only significantly different predictor of worsening liver reserve. The OS and LC rates after SBRT for HCC were satisfactory. However, the PFS was poor, and recurrent HCC will require additional treatment. It is clinically important to predict the liver reserve capacity after SBRT, and the baseline ALBI score is a useful predictor.","PeriodicalId":16922,"journal":{"name":"Journal of Radiation Research","volume":" ","pages":"244-250"},"PeriodicalIF":2.0,"publicationDate":"2024-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10959440/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139983140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mechanistic insights into the survival curve of HeLa cells with a short shoulder and their S phase-specific sensitivity†. 短肩 HeLa 细胞存活曲线及其 S 期特异性敏感性的机理启示†。

IF 2 4区医学

Journal of Radiation Research Pub Date : 2024-03-22 DOI: 10.1093/jrr/rrad097

Kenshi Komatsu, Hiroshi Tauchi

引用次数: 0

Cone-beam computed tomography-guided online adaptive radiotherapy for pharyngeal cancer with whole neck irradiation: dose-volume histogram analysis between adapted and scheduled plans. 锥形束计算机断层扫描引导的咽癌全颈部照射在线自适应放疗：自适应计划与预定计划的剂量-体积直方图分析。

IF 2 4区医学

Journal of Radiation Research Pub Date : 2024-03-22 DOI: 10.1093/jrr/rrad103

Takuya Uehara, Yasumasa Nishimura, Kazuki Ishikawa, Masahiro Inada, Kenji Matsumoto, Hiroshi Doi, Hajime Monzen, Yukinori Matsuo

{"title":"Cone-beam computed tomography-guided online adaptive radiotherapy for pharyngeal cancer with whole neck irradiation: dose-volume histogram analysis between adapted and scheduled plans.","authors":"Takuya Uehara, Yasumasa Nishimura, Kazuki Ishikawa, Masahiro Inada, Kenji Matsumoto, Hiroshi Doi, Hajime Monzen, Yukinori Matsuo","doi":"10.1093/jrr/rrad103","DOIUrl":"10.1093/jrr/rrad103","url":null,"abstract":"The present study aimed to evaluate whether an adapted plan with Ethos™ could be used for pharyngeal cancer. Ten patients with pharyngeal cancer who underwent chemoradiotherapy with available daily cone-beam computed tomography (CBCT) data were included. Simulated treatments were generated on the Ethos™ treatment emulator using CBCTs every four to five fractions for two plans: adapted and scheduled. The simulated treatments were divided into three groups: early (first-second week), middle (third-fourth week), and late (fifth-seventh week) periods. Dose-volume histogram parameters were compared for each period between the adapted and scheduled plans in terms of the planning target volume (PTV) (D98%, D95%, D50% and D2%), spinal cord (Dmax and D1cc), brainstem (Dmax) and ipsilateral and contralateral parotid glands (Dmedian and Dmean). The PTV D98%, D95% and D2% of the adapted plan were significantly higher than those of the scheduled plans in all periods, except for D98% in the late period. The adapted plan significantly reduced the spinal cord Dmax and D1cc compared with the scheduled plan in all periods. Ipsilateral and contralateral parotid glands Dmean of the adapted plan were lower than those of scheduled plan in the late period. In conclusion, the present study revealed that the adapted plans could maintain PTV coverage while reducing the doses to organs at risk in each period compared with scheduled plans.","PeriodicalId":16922,"journal":{"name":"Journal of Radiation Research","volume":" ","pages":"223-230"},"PeriodicalIF":2.0,"publicationDate":"2024-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10959439/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139542680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Application of a derivative of human defensin 5 to treat ionizing radiation-induced enterogenic infection. 应用人类防御素 5 的衍生物治疗电离辐射引起的肠源性感染。

IF 2 4区医学

Journal of Radiation Research Pub Date : 2024-03-22 DOI: 10.1093/jrr/rrad104

Gaomei Zhao, Yingjuan He, Yin Chen, Yiyi Jiang, Chenwenya Li, Tainong Xiong, Songling Han, Yongwu He, Jining Gao, Yongping Su, Junping Wang, Cheng Wang

{"title":"Application of a derivative of human defensin 5 to treat ionizing radiation-induced enterogenic infection.","authors":"Gaomei Zhao, Yingjuan He, Yin Chen, Yiyi Jiang, Chenwenya Li, Tainong Xiong, Songling Han, Yongwu He, Jining Gao, Yongping Su, Junping Wang, Cheng Wang","doi":"10.1093/jrr/rrad104","DOIUrl":"10.1093/jrr/rrad104","url":null,"abstract":"Enterogenic infection is a common complication for patients with radiation injury and requires efficient therapeutics in the clinic. Herein, we evaluated the promising drug candidate T7E21RHD5, which is a peptide derived from intestinal Paneth cell-secreted human defensin 5. Oral administration of this peptide alleviated the diarrhea symptoms of mice that received total abdominal irradiation (TAI, γ-ray, 12 Gy) and improved survival. Pathologic analysis revealed that T7E21RHD5 elicited an obvious mitigation of ionizing radiation (IR)-induced epithelial damage and ameliorated the reduction in the levels of claudin, zonula occluden 1 and occludin, three tight junction proteins in the ileum. Additionally, T7E21RHD5 regulated the gut microbiota in TAI mice by remodeling β diversity, manifested as a reversal of the inverted proportion of Bacteroidota to Firmicutes caused by IR. T7E21RHD5 treatment also decreased the abundance of pathogenic Escherichia-Shigella but significantly increased the levels of Alloprevotella and Prevotellaceae_NK3B31, two short-chain fatty acid-producing bacterial genera in the gut. Accordingly, the translocation of enterobacteria and lipopolysaccharide to the blood, as well as the infectious inflammatory responses in the intestine after TAI, was all suppressed by T7E21RHD5 administration. Hence, this versatile antimicrobial peptide possesses promising application prospects in the treatment of IR-induced enterogenic infection.","PeriodicalId":16922,"journal":{"name":"Journal of Radiation Research","volume":" ","pages":"194-204"},"PeriodicalIF":2.0,"publicationDate":"2024-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10959430/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139542661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluating thyroid cancer risks for nuclear workers related to the Fukushima Daiichi Nuclear Power Plant accident based on LNT theory is problematic. 根据 LNT 理论评估与福岛第一核电站事故有关的核工作人员患甲状腺癌的风险是有问题的。

IF 1.9 4区医学

Journal of Radiation Research Pub Date : 2024-03-22 DOI: 10.1093/jrr/rrae002

Bobby R Scott

引用次数: 0

Effect of bolus materials on dose deposition in deep tissues during electron beam radiotherapy. 电子束放射治疗过程中，栓剂材料对深部组织剂量沉积的影响。

IF 2 4区医学

Journal of Radiation Research Pub Date : 2024-03-22 DOI: 10.1093/jrr/rrae001

Dong Kong, Jia Wu, Xudong Kong, Jianfeng Huang, Yutian Zhao, Bo Yang, Qing Zhao, Ke Gu

{"title":"Effect of bolus materials on dose deposition in deep tissues during electron beam radiotherapy.","authors":"Dong Kong, Jia Wu, Xudong Kong, Jianfeng Huang, Yutian Zhao, Bo Yang, Qing Zhao, Ke Gu","doi":"10.1093/jrr/rrae001","DOIUrl":"10.1093/jrr/rrae001","url":null,"abstract":"Several materials are utilized in the production of bolus, which is essential for superficial tumor radiotherapy. This research aimed to compare the variations in dose deposition in deep tissues during electron beam radiotherapy when employing different bolus materials. Specifically, the study developed general superficial tumor models (S-T models) and postoperative breast cancer models (P-B models). Each model comprised a bolus made of water, polylactic acid (PLA), polystyrene, silica-gel or glycerol. Geant4 was employed to simulate the transportation of electron beams within the studied models, enabling the acquisition of dose distributions along the central axis of the field. A comparison was conducted to assess the dose distributions in deep tissues. In regions where the percentage depth dose (PDD) decreases rapidly, the relative doses (RDs) in the S-T models with silica-gel bolus exhibited the highest values. Subsequently, RDs for PLA, glycerol and polystyrene boluses followed in descending order. Notably, the RDs for glycerol and polystyrene boluses were consistently below 1. Within the P-B models, RDs for all four bolus materials are consistently below 1. Among them, the smallest RDs are observed with the glycerol bolus, followed by silica-gel, PLA and polystyrene bolus in ascending order. As PDDs are ~1-3% or smaller, the differences in RDs diminish rapidly until are only around 10%. For the S-T and P-B models, polystyrene and glycerol are the most suitable bolus materials, respectively. The choice of appropriate bolus materials, tailored to the specific treatment scenario, holds significant importance in safeguarding deep tissues during radiotherapy.","PeriodicalId":16922,"journal":{"name":"Journal of Radiation Research","volume":" ","pages":"215-222"},"PeriodicalIF":2.0,"publicationDate":"2024-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10959426/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139707015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An analysis of muscle growth after proton beam therapy for pediatric cancer. 质子束治疗小儿癌症后的肌肉生长分析。

IF 2 4区医学

Journal of Radiation Research Pub Date : 2024-03-22 DOI: 10.1093/jrr/rrad105

Hazuki Nitta, Masashi Mizumoto, Yinuo Li, Yoshiko Oshiro, Hiroko Fukushima, Ryoko Suzuki, Sho Hosaka, Takashi Saito, Haruko Numajiri, Chie Kawano, Satoshi Kamizawa, Kazushi Maruo, Hideyuki Sakurai

{"title":"An analysis of muscle growth after proton beam therapy for pediatric cancer.","authors":"Hazuki Nitta, Masashi Mizumoto, Yinuo Li, Yoshiko Oshiro, Hiroko Fukushima, Ryoko Suzuki, Sho Hosaka, Takashi Saito, Haruko Numajiri, Chie Kawano, Satoshi Kamizawa, Kazushi Maruo, Hideyuki Sakurai","doi":"10.1093/jrr/rrad105","DOIUrl":"10.1093/jrr/rrad105","url":null,"abstract":"Retardation of growth and development is a well-known late effect after radiotherapy for pediatric patients. The goal of the study was to examine the effect of proton beam therapy (PBT) on the growth of muscles included in the irradiated area. The subjects were 17 pediatric patients (age ≤ 5 years) who received PBT with a treatment field including a muscle on only one side out of a pair of symmetrical bilateral muscles and had imaging evaluations for at least 1 year after PBT. The thicknesses of the irradiated and non-irradiated (contralateral) muscles were measured retrospectively on CT or MRI axial images collected before and after PBT. The change of thickness divided by the period (years) for each muscle was compared between the irradiated and contralateral sides. Correlations of muscle growth with irradiation dose and age at the start of treatment were also evaluated. The median observation period was 39.2 months. The measurement sites included the erector spinae (n = 9), gluteus maximus (n = 5) and rhomboids + trapezius (n = 3) muscles. The average changes in muscle thickness were 0.24 mm/year on the irradiated side and 1.19 mm/year on the contralateral side, showing significantly reduced growth on the irradiated side (P = 0.001). Younger patients had greater muscle growth. Irradiation dose was not significant, but muscle growth tended to decrease as the dose increased, and muscles irradiated at >50 Gy (RBE) showed little growth. These results show that muscle growth is affected by PBT and that long-term follow-up is needed to evaluate muscle growth retardation.","PeriodicalId":16922,"journal":{"name":"Journal of Radiation Research","volume":" ","pages":"251-255"},"PeriodicalIF":2.0,"publicationDate":"2024-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10959433/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139542614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preventive and therapeutic effects of low-dose whole-body irradiation on collagen-induced rheumatoid arthritis in mice. 低剂量全身辐照对胶原蛋白诱导的小鼠类风湿性关节炎的预防和治疗作用。

IF 2 4区医学

Journal of Radiation Research Pub Date : 2024-03-22 DOI: 10.1093/jrr/rrad101

Ji Young Kim, Yeong Ro Lee, Young Ae Lee, Chin-Hee Song, So Hyun Han, Seong Jun Cho, Seon Young Nam

{"title":"Preventive and therapeutic effects of low-dose whole-body irradiation on collagen-induced rheumatoid arthritis in mice.","authors":"Ji Young Kim, Yeong Ro Lee, Young Ae Lee, Chin-Hee Song, So Hyun Han, Seong Jun Cho, Seon Young Nam","doi":"10.1093/jrr/rrad101","DOIUrl":"10.1093/jrr/rrad101","url":null,"abstract":"Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by progressive joint inflammation, resulting in cartilage destruction and bone erosion. It was reported that low-dose radiation modulates immune disease. Here, we investigated whether low-dose whole-body irradiation has preventive and therapeutic effects in collagen-induced RA (CIA) mouse models. Fractionated low-dose irradiation (0.05 Gy/fraction, total doses of 0.1, 0.5 or 0.8 Gy) was administered either concurrently with CIA induction by Type II collagen immunization (preventive) or after CIA development (therapeutic). The severity of CIA was monitored using two clinical parameters, paw swelling and redness. We also measured total Immunoglobulin G (IgG) and inflammatory cytokines (interleukine (IL)-6, IL-1β and tumor necrosis factor-alpha (TNF-α)) in the serum by enzyme-linked immunosorbent assay, and we evaluated histological changes in the ankle joints by immunohistochemistry and hematoxylin and eosin staining. Low-dose irradiation reduced CIA clinical scores by up to 41% in the preventive model and by 28% in the therapeutic model, while irradiation in the preventive model reduced the typical CIA incidence rate from 82 to 56%. In addition, low-dose irradiation in the preventive model decreased total IgG by up to 23% and decreased IL-1β and TNF-α by 69 and 67%, and in the therapeutic model, decreased total IgG by up to 35% and decreased IL-1β and IL-6 by 59 and 42% with statistical significance (P < 0.01, 0.05 and 0.001). Our findings demonstrate that low-dose radiation has preventive and therapeutic anti-inflammatory effects against CIA by controlling the immune response, suggesting that low-dose radiation may represent an alternative therapy for RA, a chronic degenerative immune disease.","PeriodicalId":16922,"journal":{"name":"Journal of Radiation Research","volume":" ","pages":"177-186"},"PeriodicalIF":2.0,"publicationDate":"2024-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10959428/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139058458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0