Journal of Radiation Research最新文献_第8页

Preliminary result of combined treatment with scanning carbon-ion radiotherapy and image-guided brachytherapy for locally advanced cervical adenocarcinoma. 对局部晚期宫颈腺癌采用扫描碳离子放疗和图像引导近距离放射治疗的初步结果。

IF 1.9 4区医学

Journal of Radiation Research Pub Date : 2024-07-22 DOI: 10.1093/jrr/rrae043

Keisuke Tsuchida, Daisaku Yoshida, Satoshi Shima, Terufumi Kusunoki, Yoshiki Takayama, Hiroaki Koge, Kio Kano, Yosuke Takakusagi, Nobutaka Mizoguchi, Tadashi Kamada, Yohsuke Kusano, Hisamori Kato, Hiroyuki Katoh

{"title":"Preliminary result of combined treatment with scanning carbon-ion radiotherapy and image-guided brachytherapy for locally advanced cervical adenocarcinoma.","authors":"Keisuke Tsuchida, Daisaku Yoshida, Satoshi Shima, Terufumi Kusunoki, Yoshiki Takayama, Hiroaki Koge, Kio Kano, Yosuke Takakusagi, Nobutaka Mizoguchi, Tadashi Kamada, Yohsuke Kusano, Hisamori Kato, Hiroyuki Katoh","doi":"10.1093/jrr/rrae043","DOIUrl":"10.1093/jrr/rrae043","url":null,"abstract":"Although there is growing evidence of the efficacy of carbon-ion radiotherapy (CIRT) for locally advanced cervical adenocarcinoma, reports on combined treatment with CIRT and image-guided brachytherapy (IGBT) are scarce. We retrospectively analyzed patients with International Federation of Gynecology and Obstetrics (2008) stage II-IVA locally advanced cervical adenocarcinoma who received combined scanning CIRT (sCIRT) and IGBT between April 2019 and March 2022. sCIRT consisted of whole-pelvic irradiation with 36 Gy (relative biological effectiveness [RBE]) in 12 fractions and subsequent local boost irradiation with 19.2 Gy (RBE) in 4 fractions. Three sessions of IGBT were administered after completion of sCIRT. Concurrent chemotherapy using weekly cisplatin (40 mg/m2/week) was also administered. Efficacy, toxicity and dose-volume parameters were analyzed. Fifteen patients were included in the analysis. The median follow-up period was 25 months. The 2-year overall survival, progression-free survival and local control rates were 92.3% (95% confidence interval [CI] = 77.8-100%), 52.5% (95% CI = 26.9-78.1%) and 84.8% (95% CI = 65.2-100%), respectively. Neither severe acute toxicity necessitating treatment cessation nor grade 3 or higher late toxicity were observed. The sigmoid D2cm3 of the patient who developed grade 2 late sigmoid hemorrhage was 65.6 Gy, which exceeded the standard deviation and target dose. The combination of sCIRT and IGBT for locally advanced cervical adenocarcinoma showed acceptable efficacy and safety. Further large-scale and long-term studies are warranted to confirm the efficacy and safety of this treatment.","PeriodicalId":16922,"journal":{"name":"Journal of Radiation Research","volume":" ","pages":"512-522"},"PeriodicalIF":1.9,"publicationDate":"2024-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11262861/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141261661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of relative biological effectiveness for diseases of the circulatory system based on microdosimetry. 基于微量模拟法评估循环系统疾病的相对生物有效性。

IF 1.9 4区医学

Journal of Radiation Research Pub Date : 2024-07-22 DOI: 10.1093/jrr/rrae051

Tatsuhiko Sato, Yusuke Matsuya, Nobuyuki Hamada

{"title":"Evaluation of relative biological effectiveness for diseases of the circulatory system based on microdosimetry.","authors":"Tatsuhiko Sato, Yusuke Matsuya, Nobuyuki Hamada","doi":"10.1093/jrr/rrae051","DOIUrl":"10.1093/jrr/rrae051","url":null,"abstract":"In the next decade, the International Commission on Radiological Protection (ICRP) will issue the next set of general recommendations, for which evaluation of relative biological effectiveness (RBE) for various types of tissue reactions would be needed. ICRP has recently classified diseases of the circulatory system (DCS) as a tissue reaction, but has not recommended RBE for DCS. We therefore evaluated the mean and uncertainty of RBE for DCS by applying a microdosimetric kinetic model specialized for RBE estimation of tissue reactions. For this purpose, we analyzed several RBE data for DCS determined by past animal experiments and evaluated the radius of the subnuclear domain best fit to each experiment as a single free parameter included in the model. Our analysis suggested that RBE for DCS tends to be lower than that for skin reactions, and their difference was borderline significant due to large variances of the evaluated parameters. We also found that RBE for DCS following mono-energetic neutron irradiation of the human body is much lower than that for skin reactions, particularly at the thermal energy and around 1 MeV. This tendency is considered attributable not only to the intrinsic difference of neutron RBE between skin reactions and DCS but also to the difference in the contributions of secondary γ-rays to the total absorbed doses between their target organs. These findings will help determine RBE by ICRP for preventing tissue reactions.","PeriodicalId":16922,"journal":{"name":"Journal of Radiation Research","volume":" ","pages":"500-506"},"PeriodicalIF":1.9,"publicationDate":"2024-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11262868/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141457639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Risk perception in long-term evacuees of Futaba town, Fukushima: a cross-sectional study reveals greater concerns outside the prefecture, 12 years after the accident. 福岛县双叶镇长期疏散人员的风险意识：一项横断面研究显示，事故发生 12 年后，他们对县外的风险更加担忧。

IF 1.9 4区医学

Journal of Radiation Research Pub Date : 2024-07-22 DOI: 10.1093/jrr/rrae039

Xu Xiao, Makiko Orita, Yuya Kashiwazaki, Hitomi Matsunaga, Thu Zar Win, Jacques Lochard, Noboru Takamura

{"title":"Risk perception in long-term evacuees of Futaba town, Fukushima: a cross-sectional study reveals greater concerns outside the prefecture, 12 years after the accident.","authors":"Xu Xiao, Makiko Orita, Yuya Kashiwazaki, Hitomi Matsunaga, Thu Zar Win, Jacques Lochard, Noboru Takamura","doi":"10.1093/jrr/rrae039","DOIUrl":"10.1093/jrr/rrae039","url":null,"abstract":"For over 12 years since the 2011 East Japan Earthquake, the decontamination of radioactive materials is still incomplete. Although evacuation orders had been lifted in ~15% of Futaba town, the site of the Fukushima Daiichi Nuclear Power Plant, by August 2022, anxiety regarding the effects of nuclear radiation persists among evacuees, and their intention to return (ITR) remains low. As of August 2023, only 90 residents lived there. As the only town with government functions relocated outside Fukushima Prefecture, Futaba has more residents who evacuated outside the prefecture. Although numerous factors affect risk perception and ITR to the place of previous residence, the impact of evacuation destination on risk perception remains unknown. Therefore, this study aimed to evaluate the impact of evacuation destination on radiation risk perception. In 2022, a survey was conducted on 404 evacuees aged >18 years. The responses were compared between groups outside and inside Fukushima using the chi-square test and multivariate logistic regression analysis. Significant relationships were found between the evacuation destination and risk perception of genetic effects in the next generation (odds ratio [OR] = 1.92, 95% confidence interval [CI]: 1.15-3.20) and of the health effects of radiation (OR = 1.76, 95%CI: 1.10-2.84), which were both higher in those who had evacuated outside Fukushima. These findings stress the importance of evacuation destination choice and information access for evacuees' risk perception. Enhanced education and support efforts are necessary to help evacuees not only in Fukushima but also throughout Japan.","PeriodicalId":16922,"journal":{"name":"Journal of Radiation Research","volume":" ","pages":"549-554"},"PeriodicalIF":1.9,"publicationDate":"2024-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11262855/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141300888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lymphopenia after palliative radiotherapy for vertebral metastases. 脊椎转移瘤姑息放疗后的淋巴细胞减少症。

IF 1.9 4区医学

Journal of Radiation Research Pub Date : 2024-07-22 DOI: 10.1093/jrr/rrae038

Kazuya Takeda, Rei Umezawa, Takaya Yamamoto, Noriyoshi Takahashi, Yu Suzuki, Keita Kishida, So Omata, Keiichi Jingu

{"title":"Lymphopenia after palliative radiotherapy for vertebral metastases.","authors":"Kazuya Takeda, Rei Umezawa, Takaya Yamamoto, Noriyoshi Takahashi, Yu Suzuki, Keita Kishida, So Omata, Keiichi Jingu","doi":"10.1093/jrr/rrae038","DOIUrl":"10.1093/jrr/rrae038","url":null,"abstract":"Lymphopenia is a well-known side effect of radiotherapy and has been shown to have a negative impact on patient outcomes. However, the extent of lymphopenia caused by palliative radiotherapy and its effect on patient prognosis has not been clarified. The aim of this study was to determine the incidence and severity of lymphopenia after palliative radiotherapy for vertebral metastases and to determine their effects on patients' survival outcomes. We conducted a retrospective analysis for patients who underwent palliative radiotherapy for vertebral metastases and could be followed up for 12 weeks. Lymphocyte counts were documented at baseline and throughout the 12-week period following the start of radiotherapy and their medians and interquartile ranges (IQRs) were recorded. Exploratory analyses were performed to identify predictive factors for lymphopenia and its impact on overall survival (OS). A total of 282 cases that met the inclusion criteria were analyzed. The median baseline lymphocyte count was 1.26 × 103/μl (IQR: 0.89-1.72 × 103/μl). Peak lymphopenia occurred at a median of 26 days (IQR: 15-45 days) with a median nadir of 0.52 × 103/μl (IQR: 0.31-0.81 × 103/μl). Long-term analysis of patients surviving for 1 year showed that lymphopenia persisted at 1 year after radiotherapy. The main irradiation site, radiation field length and pretreatment lymphocyte count were significantly related to grade 3 or higher lymphopenia. Lymphopenia was identified as a significant predictor of OS by multivariate Cox regression analysis. This study demonstrated the incidence of lymphopenia after palliative radiotherapy for vertebral metastases and its effect on patients' OS.","PeriodicalId":16922,"journal":{"name":"Journal of Radiation Research","volume":" ","pages":"523-531"},"PeriodicalIF":1.9,"publicationDate":"2024-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11262856/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141179139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Knowledge domains and emerging trends in radiotherapy in oesophageal cancer from 2004 to 2023: a bibliometric analysis and visualization study. 2004年至2023年食道癌放射治疗的知识领域和新趋势：文献计量分析和可视化研究。

IF 1.9 4区医学

Journal of Radiation Research Pub Date : 2024-07-22 DOI: 10.1093/jrr/rrae040

Yue Feng, Minghe Lv, Su Zeng, Hongwei Zeng, Jingping Yu

{"title":"Knowledge domains and emerging trends in radiotherapy in oesophageal cancer from 2004 to 2023: a bibliometric analysis and visualization study.","authors":"Yue Feng, Minghe Lv, Su Zeng, Hongwei Zeng, Jingping Yu","doi":"10.1093/jrr/rrae040","DOIUrl":"10.1093/jrr/rrae040","url":null,"abstract":"Esophageal cancer (EC) is a malignant tumour with high morbidity and mortality rates. Recent studies have shown that much progress has been made in the research of radiotherapy in EC. This study aims to provide a comprehensive overview of the knowledge structure and research hotspots of radiotherapy in EC through bibliometrics. Publications related to radiotherapy in EC from 2014 to 2023 were searched on the web of science core collection database. VOSviewers, CiteSpace and R package 'bibliometrix' were used to conduct this bibliometric analysis. In total, 4258 articles from 76 countries led by China and the USA were included. The Chinese Academy of Medical Sciences-Peking Union Medical College has the highest number of publications. International Journal of Radiation Oncology Biology Physics is the most popular journal and also the most co-cited journal in this field. These publications come from 21 972 authors among which Liao Zhongxing had published the most papers and Cooper JS was co-cited most often. Neoadjuvant chemoradiotherapy and strategies based on it are the main topics in this research field. 'IMRT' and 'immunotherapy' are the primary keywords of emerging research hotspots. This is a bibliometric study that comprehensively summarizes the research trends and developments of radiotherapy in EC. This information identifies recent research frontiers and hot directions, which will provide a reference for scholars studying radiotherapy in EC.","PeriodicalId":16922,"journal":{"name":"Journal of Radiation Research","volume":" ","pages":"433-449"},"PeriodicalIF":1.9,"publicationDate":"2024-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11262863/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141261332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Quality of palliative radiotherapy assessed using quality indicators: a multicenter survey†. 使用质量指标评估姑息放射治疗的质量：一项多中心调查†。

IF 1.9 4区医学

Journal of Radiation Research Pub Date : 2024-07-22 DOI: 10.1093/jrr/rrae048

Tetsuo Saito, Naoto Shikama, Takeo Takahashi, Naoki Nakamura, Takashi Mori, Kaori Nakajima, Masahiko Koizumi, Shuhei Sekii, Takeshi Ebara, Hiroki Kiyohara, Keiko Higuchi, Atsunori Yorozu, Takeshi Nishimura, Yasuo Ejima, Hideyuki Harada, Norio Araki, Misako Miwa, Kazunari Yamada, Terufumi Kawamoto, Nobuki Imano, Joichi Heianna, Miwako Nozaki, Yuki Wada, Yu Ohkubo, Nobue Uchida, Miho Watanabe, Takashi Kosugi, Kazunari Miyazawa, Shigeo Yasuda, Hiroshi Onishi

{"title":"Quality of palliative radiotherapy assessed using quality indicators: a multicenter survey†.","authors":"Tetsuo Saito, Naoto Shikama, Takeo Takahashi, Naoki Nakamura, Takashi Mori, Kaori Nakajima, Masahiko Koizumi, Shuhei Sekii, Takeshi Ebara, Hiroki Kiyohara, Keiko Higuchi, Atsunori Yorozu, Takeshi Nishimura, Yasuo Ejima, Hideyuki Harada, Norio Araki, Misako Miwa, Kazunari Yamada, Terufumi Kawamoto, Nobuki Imano, Joichi Heianna, Miwako Nozaki, Yuki Wada, Yu Ohkubo, Nobue Uchida, Miho Watanabe, Takashi Kosugi, Kazunari Miyazawa, Shigeo Yasuda, Hiroshi Onishi","doi":"10.1093/jrr/rrae048","DOIUrl":"10.1093/jrr/rrae048","url":null,"abstract":"We sought to identify potential evidence-practice gaps in palliative radiotherapy using quality indicators (QIs), previously developed using a modified Delphi method. Seven QIs were used to assess the quality of radiotherapy for bone metastases (BoM) and brain metastases (BrM). Compliance rate was calculated as the percentage of patients for whom recommended medical care was conducted. Random effects models were used to estimate the pooled compliance rates. Of the 39 invited radiation oncologists, 29 (74%) from 29 centers participated in the survey; 13 (45%) were academic and 16 (55%) were non-academic hospitals. For the QIs, except for BoM-4, the pooled compliance rates were higher than 80%; however, for at least some of the centers, the compliance rate was lower than these pooled rates. For BoM-4 regarding steroid use concurrent with radiotherapy for malignant spinal cord compression, the pooled compliance rate was as low as 32%. For BoM-1 regarding the choice of radiation schedule, the compliance rate was higher in academic hospitals than in non-academic hospitals (P = 0.021). For BrM-3 regarding the initiation of radiotherapy without delay, the compliance rate was lower in academic hospitals than in non-academic hospitals (P = 0.016). In conclusion, overall, compliance rates were high; however, for many QIs, practice remains to be improved in at least some centers. Steroids are infrequently used concurrently with radiotherapy for malignant spinal cord compression.","PeriodicalId":16922,"journal":{"name":"Journal of Radiation Research","volume":" ","pages":"532-539"},"PeriodicalIF":1.9,"publicationDate":"2024-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11262857/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141457640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Probability of normal tissue complications for hematologic and gastrointestinal toxicity in postoperative whole pelvic radiotherapy for gynecologic malignancies using intensity-modulated proton therapy with robust optimization. 使用强度调制质子疗法进行妇科恶性肿瘤术后全盆腔放疗时，正常组织并发血液和胃肠道毒性的概率与稳健优化。

IF 2 4区医学

Journal of Radiation Research Pub Date : 2024-05-23 DOI: 10.1093/jrr/rrae008

Takaaki Yoshimura, Ryota Yamada, Rumiko Kinoshita, Taeko Matsuura, Takahiro Kanehira, Hiroshi Tamura, Kentaro Nishioka, Koichi Yasuda, Hiroshi Taguchi, Norio Katoh, Keiji Kobashi, Takayuki Hashimoto, Hidefumi Aoyama

{"title":"Probability of normal tissue complications for hematologic and gastrointestinal toxicity in postoperative whole pelvic radiotherapy for gynecologic malignancies using intensity-modulated proton therapy with robust optimization.","authors":"Takaaki Yoshimura, Ryota Yamada, Rumiko Kinoshita, Taeko Matsuura, Takahiro Kanehira, Hiroshi Tamura, Kentaro Nishioka, Koichi Yasuda, Hiroshi Taguchi, Norio Katoh, Keiji Kobashi, Takayuki Hashimoto, Hidefumi Aoyama","doi":"10.1093/jrr/rrae008","DOIUrl":"10.1093/jrr/rrae008","url":null,"abstract":"This retrospective treatment-planning study was conducted to determine whether intensity-modulated proton therapy with robust optimization (ro-IMPT) reduces the risk of acute hematologic toxicity (H-T) and acute and late gastrointestinal toxicity (GI-T) in postoperative whole pelvic radiotherapy for gynecologic malignancies when compared with three-dimensional conformal radiation therapy (3D-CRT), intensity-modulated X-ray (IMXT) and single-field optimization proton beam (SFO-PBT) therapies. All plans were created for 13 gynecologic-malignancy patients. The prescribed dose was 45 GyE in 25 fractions for 95% planning target volume in 3D-CRT, IMXT and SFO-PBT plans and for 99% clinical target volume (CTV) in ro-IMPT plans. The normal tissue complication probability (NTCP) of each toxicity was used as an in silico surrogate marker. Median estimated NTCP values for acute H-T and acute and late GI-T were 0.20, 0.94 and 0.58 × 10-1 in 3D-CRT; 0.19, 0.65 and 0.24 × 10-1 in IMXT; 0.04, 0.74 and 0.19 × 10-1 in SFO-PBT; and 0.06, 0.66 and 0.15 × 10-1 in ro-IMPT, respectively. Compared with 3D-CRT and IMXT plans, the ro-IMPT plan demonstrated significant reduction in acute H-T and late GI-T. The risk of acute GI-T in ro-IMPT plan is equivalent with IMXT plan. The ro-IMPT plan demonstrated potential clinical benefits for reducing the risk of acute H-T and late GI-T in the treatment of gynecologic malignances by reducing the dose to the bone marrow and bowel bag while maintaining adequate dose coverage to the CTV. Our results indicated that ro-IMPT may reduce acute H-T and late GI-T risk with potentially improving outcomes for postoperative gynecologic-malignancy patients with concurrent chemotherapy.","PeriodicalId":16922,"journal":{"name":"Journal of Radiation Research","volume":" ","pages":"369-378"},"PeriodicalIF":2.0,"publicationDate":"2024-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11115445/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140158378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pain response in single-fraction 8-Gy radiotherapy for painful non-bone-metastasis tumors: a single-center retrospective study. 疼痛性非骨转移肿瘤单次8Gy放疗的疼痛反应：一项单中心回顾性研究。

IF 2 4区医学

Journal of Radiation Research Pub Date : 2024-05-23 DOI: 10.1093/jrr/rrae025

Nobuki Imano, Takashi Kosugi, Kenta Konishi, Tetsuo Saito

{"title":"Pain response in single-fraction 8-Gy radiotherapy for painful non-bone-metastasis tumors: a single-center retrospective study.","authors":"Nobuki Imano, Takashi Kosugi, Kenta Konishi, Tetsuo Saito","doi":"10.1093/jrr/rrae025","DOIUrl":"10.1093/jrr/rrae025","url":null,"abstract":"The effectiveness of single-fraction 8-Gy radiotherapy for painful bone metastases has been verified in numerous randomized controlled trials. However, few reports have described the effectiveness of single-fraction 8-Gy radiotherapy in painful tumors other than bone metastases. We conducted a retrospective analysis to evaluate the pain response to single-fraction 8-Gy radiotherapy in painful non-bone-metastasis tumors. We included patients who had received single-fraction 8-Gy radiotherapy for such tumors between January 2017 and December 2022, excluding those with brain metastases, hematological tumors and those who received re-irradiation. Pain response assessment was based on the best responses documented in the medical records and conducted by two radiation oncologists. A total of 36 eligible patients were included in this study. The irradiation sites included primary lesions in eight patients, lymph node metastases in eight, muscle metastases in seven, pleural dissemination in four, skin/subcutaneous metastases in four and other sites in five. Pain response was assessed in 24 patients after radiotherapy. Pain response rate was 88% in evaluable patients; 21 of the 24 patients experienced response. The median assessment date for pain response was 37 days (range: 8-156 days) after radiotherapy. Re-irradiation was performed in four patients (11%). Single-fraction 8-Gy radiotherapy seemed to be a promising treatment option for painful non-bone-metastasis tumors and warrants further investigation.","PeriodicalId":16922,"journal":{"name":"Journal of Radiation Research","volume":" ","pages":"408-412"},"PeriodicalIF":2.0,"publicationDate":"2024-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11115466/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140892299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effective timing of hyaluronate gel injection in image-guided adaptive brachytherapy for uterine cervical cancer: a proposal of the 'adjusted dose score'. 图像引导下子宫颈癌自适应近距离放射治疗中注射透明质酸凝胶的有效时机："调整剂量评分 "建议。

IF 2 4区医学

Journal of Radiation Research Pub Date : 2024-05-23 DOI: 10.1093/jrr/rrae031

Yusaku Miyata, Etsuyo Ogo, Kenta Murotani, Naotake Tsuda, Gen Suzuki, Chiyoko Tsuji, Ryosuke Akeda, Koichiro Muraki, Chikayuki Hattori, Toshi Abe

{"title":"Effective timing of hyaluronate gel injection in image-guided adaptive brachytherapy for uterine cervical cancer: a proposal of the 'adjusted dose score'.","authors":"Yusaku Miyata, Etsuyo Ogo, Kenta Murotani, Naotake Tsuda, Gen Suzuki, Chiyoko Tsuji, Ryosuke Akeda, Koichiro Muraki, Chikayuki Hattori, Toshi Abe","doi":"10.1093/jrr/rrae031","DOIUrl":"10.1093/jrr/rrae031","url":null,"abstract":"Hyaluronate gel injection (HGI) in the rectovaginal septum and vesicovaginal septum is effective in the setting of high-dose-rate image-guided adaptive brachytherapy (IGABT) for cervical cancer. We aimed to retrospectively investigate optimal conditions for HGI to achieve optimal dose distribution with a minimum number of HGI. We classified 50 IGABT plans of 13 patients with cervical cancer who received IGABT both with and without HGI in the rectovaginal septum and vesicovaginal septum into the following two groups: plan with (number of plans = 32) and plan without (number of plans = 18) HGI. The irradiation dose parameters of high-risk clinical target volume (CTVHR) and organs at risk per fraction were compared between these groups. We also developed the adjusted dose score (ADS), reflecting the overall irradiation dose status for four organs at risk and CTVHR in one IGABT plan and investigated its utility in determining the application of HGI. HGI reduced the maximum dose to the most exposed 2.0 cm3 (D2.0 cm3) of the bladder while increasing the minimum dose covering 90% of CTVHR and the percentage of CTVHR receiving 100% of the prescription dose in one IGABT plan without causing any associated complications. An ADS of ≥2.60 was the optimum cut-off value to decide whether to perform HGI. In conclusion, HGI is a useful procedure for improving target dose distribution while reducing D2.0 cm3 in the bladder in a single IGABT plan. The ADS can serve as a useful indicator for the implementation of HGI.","PeriodicalId":16922,"journal":{"name":"Journal of Radiation Research","volume":" ","pages":"393-401"},"PeriodicalIF":2.0,"publicationDate":"2024-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11115467/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140916314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction to: Risk of thoracic soft tissue sarcoma after breast cancer radiotherapy: a population-based cohort study in Osaka, Japan. 更正：乳腺癌放疗后患胸部软组织肉瘤的风险：日本大阪的一项人群队列研究。

IF 2 4区医学

Journal of Radiation Research Pub Date : 2024-05-23 DOI: 10.1093/jrr/rrae029

引用次数: 0