DNA 双链断裂修复能力与放疗引起的正常组织毒性。

IF 1.9 4区医学 Q2 BIOLOGY

Journal of Radiation Research Pub Date : 2024-12-16 DOI:10.1093/jrr/rrae081

Ikuno Nishibuchi, Satoshi Tashiro

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引用次数: 0

摘要

放射治疗用于各种癌症的治疗，辐照技术的进步进一步扩大了其适用范围。对于放射肿瘤学家来说，即使有了这些技术进步，预测不良事件仍然是一项严峻的挑战。虽然已有许多研究预测了个体的放射敏感性，但迄今为止还没有生物标志物应用于临床。本综述重点关注γ-H2AX病灶和染色体畸变，概述它们与正常组织毒性的关系。

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DNA double-strand break repair capacity and normal tissue toxicity induced by radiotherapy.

Radiation therapy is used in the treatment of various cancers, and advancements in irradiation techniques have further expanded its applicability. For radiation oncologists, predicting adverse events remains a critical challenge, even with these technological advancements. Although numerous studies have been conducted to predict individual radiosensitivity, no biomarkers have been clinically applied thus far. This review focuses on γ-H2AX foci and chromosomal aberrations, providing an overview of their association with normal tissue toxicities.

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来源期刊

Journal of Radiation Research 医学-核医学

CiteScore

3.60

自引率

5.00%

发文量

审稿时长

4-8 weeks

期刊介绍： The Journal of Radiation Research (JRR) is an official journal of The Japanese Radiation Research Society (JRRS), and the Japanese Society for Radiation Oncology (JASTRO). Since its launch in 1960 as the official journal of the JRRS, the journal has published scientific articles in radiation science in biology, chemistry, physics, epidemiology, and environmental sciences. JRR broadened its scope to include oncology in 2009, when JASTRO partnered with the JRRS to publish the journal. Articles considered fall into two broad categories: Oncology & Medicine - including all aspects of research with patients that impacts on the treatment of cancer using radiation. Papers which cover related radiation therapies, radiation dosimetry, and those describing the basis for treatment methods including techniques, are also welcomed. Clinical case reports are not acceptable. Radiation Research - basic science studies of radiation effects on livings in the area of physics, chemistry, biology, epidemiology and environmental sciences. Please be advised that JRR does not accept any papers of pure physics or chemistry. The journal is bimonthly, and is edited and published by the JRR Editorial Committee.