使用铁轭超导开放式磁共振成像的磁共振引导质子治疗系统模拟研究:概念研究。

IF 1.9 4区 医学 Q2 BIOLOGY
Yusuke Fujii, Hideaki Ueda, Taisuke Takayanagi, Kentaro Nishioka, Takashi Mori, Takayuki Hashimoto, Hidefumi Aoyama, Kikuo Umegaki, Taeko Matsuura
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引用次数: 0

摘要

在过去十年中,与磁共振成像(MRI)相结合的放射治疗平台在 X 射线治疗中取得了巨大成功,并得到了广泛应用。与传统的 X 射线技术相比,磁共振成像技术能提供更高的软组织对比度,从而能进行更精确的放射治疗,如在治疗过程中进行自适应治疗规划和直接跟踪移动的肿瘤。核磁共振成像与质子束照射系统(PBS)的整合仍处于研究阶段。然而,这可能是有益的,因为质子治疗对解剖变化和器官运动更加敏感。在这项模拟研究中,我们考虑了将质子束照射系统整合到 0.3 T 超导开放式磁共振成像系统中。我们提出的设计方案包括质子束穿过铁轭中心的一个孔,这样就可以在保持当前 PBS 的大质子扫描场的同时,减少辐照喷嘴中的边缘场。双极磁共振成像磁体的形状是为了获得大的磁共振成像视场而设计的。为了在保持较小光束尺寸的同时准确监测光束位置和尺寸,在现有系统的基础上重新设计了光束监测装置。随后,治疗计划的质量证明了这一系统的可行性,在矩形目标和前列腺病例中,磁场不会使计划质量比没有磁场时差。尽管在临床环境中实施所提出的模拟模型仍面临许多挑战,但所提出的概念设计有助于实现磁共振引导质子治疗的初步设计。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
A simulation study of MR-guided proton therapy system using iron-yoked superconducting open MRI: a conceptual study.

Radiotherapy platforms integrated with magnetic resonance imaging (MRI) have been significantly successful and widely used in X-ray therapy over the previous decade. MRI provides greater soft-tissue contrast than conventional X-ray techniques, which enables more precise radiotherapy with on-couch adaptive treatment planning and direct tracking of moving tumors. The integration of MRI into a proton beam irradiation system (PBS) is still in the research stage. However, this could be beneficial as proton therapy is more sensitive to anatomical changes and organ motion. In this simulation study, we considered the integration of PBS into the 0.3-T superconducting open MRI system. Our proposed design involves proton beams traversing a hole at the center of the iron yoke, which allows for a reduced fringe field in the irradiation nozzle while maintaining a large proton scan field of the current PBS. The shape of the bipolar MRI magnets was derived to achieve a large MRI field-of-view. To monitor the beam position and size accurately while maintaining a small beam size, the beam monitor installation was redesigned from the current system. The feasibility of this system was then demonstrated by the treatment plan quality, which showed that the magnetic field did not deteriorate the plan quality from that without the magnetic field for both a rectangular target and a prostate case. Although numerous challenges remain before the proposed simulation model can be implemented in a clinical setting, the presented conceptual design could assist in the initial design for the realization of the MR-guided proton therapy.

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来源期刊
CiteScore
3.60
自引率
5.00%
发文量
86
审稿时长
4-8 weeks
期刊介绍: The Journal of Radiation Research (JRR) is an official journal of The Japanese Radiation Research Society (JRRS), and the Japanese Society for Radiation Oncology (JASTRO). Since its launch in 1960 as the official journal of the JRRS, the journal has published scientific articles in radiation science in biology, chemistry, physics, epidemiology, and environmental sciences. JRR broadened its scope to include oncology in 2009, when JASTRO partnered with the JRRS to publish the journal. Articles considered fall into two broad categories: Oncology & Medicine - including all aspects of research with patients that impacts on the treatment of cancer using radiation. Papers which cover related radiation therapies, radiation dosimetry, and those describing the basis for treatment methods including techniques, are also welcomed. Clinical case reports are not acceptable. Radiation Research - basic science studies of radiation effects on livings in the area of physics, chemistry, biology, epidemiology and environmental sciences. Please be advised that JRR does not accept any papers of pure physics or chemistry. The journal is bimonthly, and is edited and published by the JRR Editorial Committee.
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