癌症患者中与辐射相关的心血管疾病:一位肿瘤心脏病专家的最新见解。

IF 1.9 4区 医学 Q2 BIOLOGY
Masae Uehara,Norifumi Bekki,Taro Shiga
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引用次数: 0

摘要

辐射相关心血管疾病(RACD)是一种以心包炎、心肌损伤、瓣膜性心脏病、心力衰竭、血管病变和缺血性心脏病为特征的复杂疾病,预后一般较差。虽然 RACD 可能是急性的,但它通常在胸部受到辐射后的数年甚至数十年才表现出来。随着癌症幸存者人数的不断增加,RACD 很可能成为心脏肿瘤学中的一个重要问题。这篇综述从心脏病学的角度讨论了放射治疗(RT)前的准备、RT 周围的患者管理和 RT 后的长期随访计划。此外,还介绍了一种新型立体定向放射治疗技术,该技术已被用于治疗顽固性心律失常。在放疗期间和放疗后对患者进行适当的检查和管理对支持癌症患者接受治疗以延长预期寿命至关重要。需要一个多学科团队来确定如何管理接受 RT 的患者以减少 RACD、检测 RACD 的早期阶段并为 RACD 提供最佳治疗。最近的研究越来越多地报道了使用新设备进行诊断的进展,这些设备有可能检测出 RACD 的早期阶段,同时也有越来越多的证据表明 RACD 的最佳治疗方法。本综述概述了近期的研究和指南,报告了最新的研究结果,并指出了与 RACD 有关的尚未解决的问题,这些问题需要在未来的研究中加以验证。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Radiation-associated cardiovascular disease in patients with cancer: current insights from a cardio-oncologist.
Radiation-associated cardiovascular disease (RACD), a complex disease characterized with pericarditis, myocardial damage, valvular heart diseases, heart failure, vasculopathy and ischemic heart disease, has a generally poor prognosis. While RACD may be acute, it often manifests in the late years or even decades following radiation exposure to the chest. With an increasing number of cancer survivors, RACD is likely to become an important issue in cardio-oncology. This review discusses pre-radiation therapy (RT) preparation, peri-RT patient management and long follow-up planning post-RT from a cardiology perspective. Additionally, a novel technique of stereotactic radiotherapy, which has been applied for the treatment of intractable cardiac arrhythmias, is presented. Appropriate patient examination and management during and after RT are essential to support patients undergoing cancer treatment to improve long life expectancy. A multidisciplinary team is needed to determine how to manage patients who receive RT to reduce RACD, to detect early phases of RACD and to provide the best treatment for RACD. Recent studies increasingly report advances in diagnosis using new equipment that has the potential to detect early phases of RACD, along with growing evidence for the optimal treatment for RACD. This review provides an overview of recent studies and guidelines to report on the latest findings, and to identify unresolved issues surrounding RACD that require validation in future studies.
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来源期刊
CiteScore
3.60
自引率
5.00%
发文量
86
审稿时长
4-8 weeks
期刊介绍: The Journal of Radiation Research (JRR) is an official journal of The Japanese Radiation Research Society (JRRS), and the Japanese Society for Radiation Oncology (JASTRO). Since its launch in 1960 as the official journal of the JRRS, the journal has published scientific articles in radiation science in biology, chemistry, physics, epidemiology, and environmental sciences. JRR broadened its scope to include oncology in 2009, when JASTRO partnered with the JRRS to publish the journal. Articles considered fall into two broad categories: Oncology & Medicine - including all aspects of research with patients that impacts on the treatment of cancer using radiation. Papers which cover related radiation therapies, radiation dosimetry, and those describing the basis for treatment methods including techniques, are also welcomed. Clinical case reports are not acceptable. Radiation Research - basic science studies of radiation effects on livings in the area of physics, chemistry, biology, epidemiology and environmental sciences. Please be advised that JRR does not accept any papers of pure physics or chemistry. The journal is bimonthly, and is edited and published by the JRR Editorial Committee.
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