Journal of Radiation Research最新文献_第3页

Utility of 2-[18F]Fluoro-2-deoxy-D-glucose positron emission tomography/computed tomography in assessing treatment response after chemoradiotherapy for cervical cancer. 2-[18F]氟-2-脱氧-d -葡萄糖正电子发射断层扫描/计算机断层扫描在评估宫颈癌放化疗后治疗反应中的应用

IF 2.1 4区医学

Journal of Radiation Research Pub Date : 2026-10-09 DOI: 10.1093/jrr/rrag060

Yuto Kishimoto, Motoharu Sasaki, Hideki Otsuka, Akiko Kubo, Chisato Tonoiso, Takashi Kawanaka, Takaharu Kudoh, Hitoshi Ikushima

{"title":"Utility of 2-[18F]Fluoro-2-deoxy-D-glucose positron emission tomography/computed tomography in assessing treatment response after chemoradiotherapy for cervical cancer.","authors":"Yuto Kishimoto, Motoharu Sasaki, Hideki Otsuka, Akiko Kubo, Chisato Tonoiso, Takashi Kawanaka, Takaharu Kudoh, Hitoshi Ikushima","doi":"10.1093/jrr/rrag060","DOIUrl":"10.1093/jrr/rrag060","url":null,"abstract":"Cervical cancer is the fourth most common malignancy globally. As many cases are locally advanced, early prediction of local recurrence, which often occurs within 2 years of chemoradiotherapy (CCRT), is crucial. The National Comprehensive Cancer Network Guidelines recommend post-treatment 2-[18F]fluoro-2-deoxy-D-glucose positron emission tomography/computed tomography (18F-FDG-PET/CT) for response assessment, but this is not standard in Japan. We aimed to investigate the utility of 18F-FDG-PET/CT in assessing primary tumor response after CCRT for cervical cancer. Seventy-three patients with cervical cancer who received curative CCRT and underwent pre- and post-treatment magnetic resonance imaging and 18F-FDG-PET/CT were analyzed. We collected PET metrics (maximum standardized uptake value [SUVmax], metabolic tumor volume [MTV], total lesion glycolysis [TLG]) and classified the response. Receiver operating characteristic (ROC) curve analysis was performed on the post-treatment PET data. Univariate analysis was performed to determine the prognostic factors for local control. ROC curve analysis yielded high negative predictive values for local recurrence of post-treatment MTV, SUVmax and TLG. Univariate analysis showed significant differences in local control for post-treatment MTV, SUVmax, TLG and PET Response Criteria in Solid Tumors, but not for Response Evaluation Criteria in Solid Tumors (RECIST). Functional assessment using 18F-FDG-PET/CT after CCRT for cervical cancer is useful for complementing conventional morphological evaluation and improving the accuracy of response assessment.","PeriodicalId":16922,"journal":{"name":"Journal of Radiation Research","volume":" ","pages":"810-819"},"PeriodicalIF":2.1,"publicationDate":"2026-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13650714/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148679072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A patch-based bolus technique for total scalp irradiation: dosimetric impact of conformity and reproducibility. 一种基于贴片的全头皮放射丸技术：一致性和可重复性的剂量学影响。

IF 2.1 4区医学

Journal of Radiation Research Pub Date : 2026-10-09 DOI: 10.1093/jrr/rrag069

Takahiro Kato, Hiroshi Niwayama, Yuki Tominaga, Yosuke Nagasawa, Daiki Senzaki, Takaomi Harada, Hisashi Sato

{"title":"A patch-based bolus technique for total scalp irradiation: dosimetric impact of conformity and reproducibility.","authors":"Takahiro Kato, Hiroshi Niwayama, Yuki Tominaga, Yosuke Nagasawa, Daiki Senzaki, Takaomi Harada, Hisashi Sato","doi":"10.1093/jrr/rrag069","DOIUrl":"10.1093/jrr/rrag069","url":null,"abstract":"Total scalp irradiation (TSI) for scalp angiosarcoma remains technically challenging because of the large, highly curved target geometry and the need for reliable bolus application. This study aimed to develop a practical method to improve bolus conformity using commercially available bolus and to evaluate the dosimetric impact of bolus reproducibility in volumetric-modulated arc therapy (VMAT)-based TSI. An anthropomorphic head phantom was used to simulate TSI conditions. A three-segment 'patch bolus' method was developed to enhance conformity and setup stability. Treatment plans were generated using HyperArc with identical optimization parameters for three conditions: virtual bolus, single-sheet bolus and patch bolus. To assess reproducibility, the patch bolus was reapplied and rescanned 10 times, and dose distributions were recalculated on each dataset after rigid registration to isolate bolus-related variations. The patch bolus method substantially reduced air gaps compared with the single-sheet approach and achieved target coverage comparable to the virtual bolus condition. In contrast, the single-sheet bolus resulted in inferior coverage in regions with poor contact. Repeated application of the patch bolus demonstrated high reproducibility, with variations within 2% for most dose-volume metrics. Although relative variations exceeding 5% were observed for the lens, absolute doses remained low and clinically negligible. These findings indicate that VMAT-based TSI is relatively robust against minor bolus variations. The proposed patch bolus method provides improved conformity, reproducibility and workflow efficiency, representing a simple and clinically feasible strategy for TSI using external beam radiotherapy.","PeriodicalId":16922,"journal":{"name":"Journal of Radiation Research","volume":" ","pages":"872-879"},"PeriodicalIF":2.1,"publicationDate":"2026-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13650699/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148765179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The role of cytosolic mitochondrial DNA as a mitochondrial danger signal for stromal fibroblasts in forming the tumor-promoting microenvironment following radiation exposure. 辐射暴露后，细胞质线粒体DNA作为间质成纤维细胞形成促肿瘤微环境的线粒体危险信号的作用。

IF 2.1 4区医学

Journal of Radiation Research Pub Date : 2026-10-09 DOI: 10.1093/jrr/rrag054

Tsutomu Shimura

{"title":"The role of cytosolic mitochondrial DNA as a mitochondrial danger signal for stromal fibroblasts in forming the tumor-promoting microenvironment following radiation exposure.","authors":"Tsutomu Shimura","doi":"10.1093/jrr/rrag054","DOIUrl":"10.1093/jrr/rrag054","url":null,"abstract":"Inflammation plays an essential role in detecting foreign pathogens, which triggers a defensive response, eliminates infected tissue and facilitates tissue repair. However, when acute inflammation progresses to chronic inflammation, it contributes to the development of diseases, such as cancer. Both the inflammatory response and gene mutations are key elements of radiation-induced carcinogenesis; however, the molecular mechanisms underlying the initiation of the inflammatory response following radiation have not been fully understood yet. We hypothesize that cytosolic mitochondrial DNA is a mediator of the inflammatory response in radiation-induced tumor microenvironment formation. Using normal human fibroblasts and mice, we recently demonstrated that radiation fragmented mitochondrial DNA, which was subsequently released into the cytoplasm. Unlike nuclear DNA, cytosolic mitochondrial DNA is considered foreign by the DNA sensor cyclic GMP-AMP synthase, cGAS, and triggers an immune response similar to that evoked by viral DNA. Thus, cytosolic mitochondrial DNA is a mediator of inflammation in various physiological and pathological contexts. In addition, mitochondrial DNA fragments are released into the extracellular matrix. Such mitochondrial danger signals generated by fibroblasts in response to radiation exposure contribute to inflammation. Here, this review discusses the manner in which mitochondrial danger signals alter the microenvironment of tissue stem cells, or the stem cell niche, and contributes to the formation of the tumor microenvironment. In addition, the mechanisms underlying radiation-induced carcinogenesis are addressed.","PeriodicalId":16922,"journal":{"name":"Journal of Radiation Research","volume":" ","pages":"685-693"},"PeriodicalIF":2.1,"publicationDate":"2026-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13650715/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148549279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Urinary tritium concentrations and associated environmental factors among residents living near a nuclear power plant in South Korea: a community-based biomonitoring study. 韩国核电站附近居民尿氚浓度及相关环境因素：基于社区的生物监测研究

IF 2.1 4区医学

Journal of Radiation Research Pub Date : 2026-10-09 DOI: 10.1093/jrr/rrag068

Minyu Qin, Keon Wook Kang, Hyun Chul Lee, Yong Hoon Jeong, Seokyoung Ahn, Insuk Song, Sang Jun Han, Seok-Ju Yoo, Ji-Hyuk Park, JaeYun Lee, JaeSeon Ryu, HyunChul Park, Kwan Lee

{"title":"Urinary tritium concentrations and associated environmental factors among residents living near a nuclear power plant in South Korea: a community-based biomonitoring study.","authors":"Minyu Qin, Keon Wook Kang, Hyun Chul Lee, Yong Hoon Jeong, Seokyoung Ahn, Insuk Song, Sang Jun Han, Seok-Ju Yoo, Ji-Hyuk Park, JaeYun Lee, JaeSeon Ryu, HyunChul Park, Kwan Lee","doi":"10.1093/jrr/rrag068","DOIUrl":"10.1093/jrr/rrag068","url":null,"abstract":"Abnormally high tritium levels were identified at the Wolsong nuclear power plant (NPP) in 2019, prompting growing concern among nearby residents and public health authorities. The study aimed to investigate tritium internal exposure concentrations among residents and to identify potential internal exposure pathways. A total of 359 residents living within 15 km of the NPP with no occupational history at the facility were enrolled in this cross-sectional study in 2021. Participants were categorized into three distance-based zones. Tritium concentrations were measured in urine samples and local water resources. Statistical analyses were conducted using appropriate parametric tests and linear regression based on log-transformed data. The results showed that residents within 10 km of the NPP exhibited significantly higher urinary tritium levels (mean ± SD: 3.28 ± 2.28 Bq/L; 95% CI: 2.87-3.69; P < 0.05) compared with those living further away. Tap water within 5 km contained the highest tritium levels (6.6 ± 1.6 Bq/L), whereas groundwater in the 5-10 km zone showed elevated levels (2.0 ± 1.9 Bq/L). Participants who had visited the NPP in the previous 2 years presented higher urinary tritium levels than those who had not (P < 0.01). Overall, this study showed that urinary tritium concentrations varied according to residential distance and water resource. All measured urinary tritium levels were far below international safety limits. These findings establish essential baseline data for future surveillance and risk communication on nuclear-related public health issues.","PeriodicalId":16922,"journal":{"name":"Journal of Radiation Research","volume":" ","pages":"754-762"},"PeriodicalIF":2.1,"publicationDate":"2026-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13650717/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148794781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Definitive radiotherapy for early stage hypopharyngeal cancer (T1-2N0M0): a retrospective study of clinical outcomes and prognostic factors. 早期下咽癌（T1-2N0M0）的明确放疗：临床结局和预后因素的回顾性研究

IF 2.1 4区医学

Journal of Radiation Research Pub Date : 2026-09-30 DOI: 10.1093/jrr/rrag088

Tsuyoshi Fukuzawa, Toshihisa Kuroki, Shigeto Kabuki, Yoshitsugu Matsumoto, Kenji Okami, Akitomo Sugawara

{"title":"Definitive radiotherapy for early stage hypopharyngeal cancer (T1-2N0M0): a retrospective study of clinical outcomes and prognostic factors.","authors":"Tsuyoshi Fukuzawa, Toshihisa Kuroki, Shigeto Kabuki, Yoshitsugu Matsumoto, Kenji Okami, Akitomo Sugawara","doi":"10.1093/jrr/rrag088","DOIUrl":"https://doi.org/10.1093/jrr/rrag088","url":null,"abstract":"Hypopharyngeal carcinoma (HPC) is an aggressive malignancy that is often diagnosed at an advanced stage. Advances in narrowband imaging have increased the early detection rate of HPC. Definitive radiotherapy (RT) is a noninvasive, organ-preserving option recommended for early stage (T1-2N0M0) disease; however, its clinical outcomes remain limited. This study retrospectively evaluated the clinical outcomes of definitive RT for early stage HPC. We retrospectively analyzed 55 patients with early stage HPC who were treated with RT between 2013 and 2023. Treatments included volumetric-modulated arc therapy or three-dimensional conformal radiotherapy with elective nodal irradiation. Chemoradiotherapy was administered to selected patients with stage T2 disease. Survival outcomes were assessed using Kaplan-Meier and Cox models. Median follow-up was 43 months. The 5-year overall survival (OS), progression-free survival, and cancer-specific survival rates were 65%, 57%, and 82%, respectively. Local control, locoregional control and laryngeal preservation rate at 5 years were 79%, 74%, and 91%, respectively. Initial recurrences were locoregional, with local recurrence in 10 of 55 patients (18%) and regional lymph node recurrence in three of 55 patients (5.4%). In univariate analysis, older age (≧71 years) and a history of esophageal cancer were associated with significantly worse OS. The multivariate analysis confirmed that older age and a history of esophageal cancer were independent predictors of OS. RT for early stage HPC provides favorable oncological outcomes and high rates of laryngeal preservation. However, OS was strongly influenced by age and a history of esophageal cancer, highlighting the need for treatment selection and follow-up, including surveillance for second primary esophageal cancer.","PeriodicalId":16922,"journal":{"name":"Journal of Radiation Research","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149111325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Risk stratification for distant metastasis after postoperative (chemo)radiotherapy in head and neck squamous cell carcinoma. 头颈部鳞状细胞癌术后（化疗）放疗后远处转移的危险分层。

IF 2.1 4区医学

Journal of Radiation Research Pub Date : 2026-09-30 DOI: 10.1093/jrr/rrag087

Midori Yui, Yuhei Koike, Satoaki Nakamura, Sari Yamakawa, Ken Shigeyama, Takuo Fujisawa, Kensuke Suzuki, Tomofumi Sakagami, Noboru Tanigawa

{"title":"Risk stratification for distant metastasis after postoperative (chemo)radiotherapy in head and neck squamous cell carcinoma.","authors":"Midori Yui, Yuhei Koike, Satoaki Nakamura, Sari Yamakawa, Ken Shigeyama, Takuo Fujisawa, Kensuke Suzuki, Tomofumi Sakagami, Noboru Tanigawa","doi":"10.1093/jrr/rrag087","DOIUrl":"https://doi.org/10.1093/jrr/rrag087","url":null,"abstract":"With the emergence of immune checkpoint inhibitors for resectable locally advanced head and neck squamous cell carcinoma (HNSCC), identifying patients most likely to experience distant relapse after standard postoperative treatment has become increasingly important. The purpose of this study was to evaluate recurrence patterns, identify clinicopathological factors of distant metastasis and develop a practical risk stratification model after postoperative radiotherapy (PORT) or chemoradiotherapy (POCRT). We retrospectively analyzed 78 patients with HNSCC who underwent curative-intent resection followed by PORT or POCRT between 2017 and 2024. Distant metastasis-free survival (DMFS) was measured from radiotherapy completion, and the cumulative incidence of distant metastasis was estimated with death as a competing event. The four prespecified risk factors were hypopharyngeal primary site, contralateral cervical nodal metastasis, nodal involvement at level IV or below and extranodal extension. During a median follow-up of 50 months, 39 patients experienced recurrence, and distant metastasis was the most common first failure. Twelve-month DMFS rates in the low- (no factors), intermediate- (1 factor) and high-risk (≥2 factors) groups were 85.8%, 79.3% and 33.3%, respectively. After adjustment for T category, high-risk status remained associated with worse DMFS (hazard ratio [HR], 5.43; 95% confidence interval [CI], 2.24-13.15) and a higher cumulative incidence of distant metastasis (subdistribution HR, 11.86; 95% CI, 3.54-39.76). This simple stratification may help identify patients at high risk of early distant relapse after PORT or POCRT, in whom intensification of postoperative treatment warrants evaluation. Prospective validation is required.","PeriodicalId":16922,"journal":{"name":"Journal of Radiation Research","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149111341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Time-resolved lipidomic atlas of the murine lung response to acute ionizing radiation. 小鼠肺对急性电离辐射反应的时间分辨脂质组学图谱。

IF 2.1 4区医学

Journal of Radiation Research Pub Date : 2026-09-30 DOI: 10.1093/jrr/rrag080

Shuhei Aramaki, Maxime Dubail, Wenxin Li, Chi Zhang, Rintaro Yamashita, Tsutomu Ikenohira, Atsushi Baba, Shoshiro Hirayama, Tomoaki Kahyo, Mitsutoshi Setou, Katsumasa Nakamura

{"title":"Time-resolved lipidomic atlas of the murine lung response to acute ionizing radiation.","authors":"Shuhei Aramaki, Maxime Dubail, Wenxin Li, Chi Zhang, Rintaro Yamashita, Tsutomu Ikenohira, Atsushi Baba, Shoshiro Hirayama, Tomoaki Kahyo, Mitsutoshi Setou, Katsumasa Nakamura","doi":"10.1093/jrr/rrag080","DOIUrl":"https://doi.org/10.1093/jrr/rrag080","url":null,"abstract":"The lung is among the most radiosensitive organs and a principal dose-limiting organ in thoracic radiotherapy, yet the acute metabolic consequences of irradiation at the lipidomic level remain poorly characterized. We constructed a time-resolved lipidomic atlas of the murine lung response to high-dose irradiation. Male C57BL/6 J mice received a single 10 Gy whole-body X-ray dose, and lungs were collected at 5 minutes, 1 hour, 4 hours, and 24 hours post-exposure (n = 5 per group) and analyzed by untargeted liquid chromatography-tandem mass spectrometry. Radiation triggered rapid and coordinated lipid remodeling. Principal component analysis revealed a structured temporal trajectory, and oxidized lipid species increased significantly by 24 hours. Pulmonary surfactant lipids, including dipalmitoylphosphatidylcholine and phosphatidylglycerol, underwent early and progressive oxidation. Membrane signaling lipids shifted in a manner consistent with a transient pro-survival bias, with ceramide depletion, sphingomyelin accumulation, and phosphatidylserine oxidation. Mitochondrial lipids displayed a coordinated triad of early cardiolipin oxidation, progressive coenzyme Q depletion, and sustained phosphatidylethanolamine accumulation. Lysobisphosphatidic acid accumulated steadily, consistent with endolysosomal activation, while storage triglycerides and diglycerides were rapidly mobilized and free fatty acids accumulated at later time points. Class-level changes were temporally ordered and compartmentally organized, indicating that the acute lipid response is not confined to oxidative damage. The lipid classes involved overlap with those implicated in ferroptosis, mitophagy, lipophagy, and surfactant biology, although these processes were not assessed directly here. This atlas is offered as a descriptive resource for mechanistic study of radiation-induced lung injury.","PeriodicalId":16922,"journal":{"name":"Journal of Radiation Research","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149111373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Long-term outcomes of high-dose hyperfractionated thoracic radiotherapy for limited-stage small-cell lung cancer. 高剂量高分割胸部放疗治疗有限期小细胞肺癌的长期疗效。

IF 2.1 4区医学

Journal of Radiation Research Pub Date : 2026-09-28 DOI: 10.1093/jrr/rrag077

Yasuhito Hagiwara, Yuuki Kuroda, Kenji Takai, Mayumi Ichikawa, Masayoshi Yamada, Yasuhiro Sugai, Masashi Koto

{"title":"Long-term outcomes of high-dose hyperfractionated thoracic radiotherapy for limited-stage small-cell lung cancer.","authors":"Yasuhito Hagiwara, Yuuki Kuroda, Kenji Takai, Mayumi Ichikawa, Masayoshi Yamada, Yasuhiro Sugai, Masashi Koto","doi":"10.1093/jrr/rrag077","DOIUrl":"https://doi.org/10.1093/jrr/rrag077","url":null,"abstract":"Concurrent chemoradiotherapy with thoracic radiotherapy of 45 Gy in 30 twice-daily fractions is the standard treatment for limited-stage small-cell lung cancer (LS-SCLC). However, the optimal thoracic radiotherapy dose remains uncertain. This study aimed to evaluate the efficacy and safety of high-dose hyperfractionated radiotherapy for LS-SCLC. We retrospectively analyzed 38 patients with LS-SCLC who received high-dose hyperfractionated radiotherapy at multiple institutions in Yamagata Prefecture between 2008 and 2012. Radiotherapy was delivered at a total dose of 60 Gy in 50 twice-daily fractions of 1.2 Gy. The median follow-up was 31 months for the entire cohort and 107 months for surviving patients. The 3- and 5-year overall survival and progression-free survival were 46.1 and 26.2%, and 36.9 and 26.9%, respectively. The cumulative incidence of local recurrence in the high-dose region at 3- and 5-years was 13.5 and 18.9%, respectively. Grade 3 radiation pneumonitis occurred in three patients (7.9%). No grade 4 or higher radiation pneumonitis or grade 3 or higher esophagitis was observed. Grade 4 cytopenia occurred in six patients (16%). High-dose hyperfractionated radiotherapy may be a feasible dose-escalated option for patients with LS-SCLC, with acceptable toxicity. Published data on the long-term outcomes of this specific regimen are limited.","PeriodicalId":16922,"journal":{"name":"Journal of Radiation Research","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149081001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antitumor effects of combined local plasma and anti-PD-1 antibody treatment in a murine colon tumor model. 局部血浆联合抗pd -1抗体治疗小鼠结肠肿瘤模型的抗肿瘤作用。

IF 2.1 4区医学

Journal of Radiation Research Pub Date : 2026-09-28 DOI: 10.1093/jrr/rrag079

Hiroki Okada, Misa Iizawa, Yukiko Wadamori, Hideyuki Yanai, Ryo Ono

{"title":"Antitumor effects of combined local plasma and anti-PD-1 antibody treatment in a murine colon tumor model.","authors":"Hiroki Okada, Misa Iizawa, Yukiko Wadamori, Hideyuki Yanai, Ryo Ono","doi":"10.1093/jrr/rrag079","DOIUrl":"https://doi.org/10.1093/jrr/rrag079","url":null,"abstract":"Cold atmospheric-pressure plasma has been suggested to induce antitumor immune responses as a local anticancer treatment. In this study, we investigated whether streamer discharge plasma, a type of cold atmospheric-pressure plasma, enhances the antitumor effects of anti-programmed cell death protein 1 (PD-1) antibody therapy in a murine colon tumor model. Colon26 tumor-bearing mice were randomly assigned to four groups: Control, anti-PD-1 antibody alone, plasma treatment alone and combination treatment with anti-PD-1 antibody and plasma groups. Three independent tumor growth experiments were performed. Under conditions in which anti-PD-1 antibody and plasma treatments alone showed limited effects on tumor growth, the combination treatment delayed tumor growth. Analysis of longitudinal tumor growth curves using a linear mixed model revealed a significant interaction among time, anti-PD-1 antibody treatment and plasma treatment in the integrated dataset, supporting a combined effect on tumor growth. Exploratory flow cytometric analysis showed a numerically lower percentage of F4/80+ macrophage-enriched cells and numerically higher percentages of CD8+ T cell-related populations in the combination group. However, no statistically significant interaction between plasma treatment and anti-PD-1 antibody treatment was detected for any of the flow cytometric parameters. Overall, the pooled analysis supported a combined antitumor effect of local streamer discharge plasma and anti-PD-1 antibody treatment, although the magnitude of the combined effect varied among the three experiments.","PeriodicalId":16922,"journal":{"name":"Journal of Radiation Research","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149080943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Revision of lymph node classification in the Japanese Classification of Esophageal Cancer and its impact on definitive chemoradiotherapy for stage IV esophageal cancer: a single-institution retrospective study. 日本食管癌分类中淋巴结分类的修订及其对IV期食管癌明确放化疗的影响：一项单机构回顾性研究

IF 2.1 4区医学

Journal of Radiation Research Pub Date : 2026-09-25 DOI: 10.1093/jrr/rrag083

Tetsugaku Shinozaki, Yuki Wada, Satoshi Kumagai, Tasuku Kume, Noriko Takagi, Kenta Watanabe, Tamotsu Matsuhashi, Katsunori Iijima, Yushi Nagaki, Akiyuki Wakita, Yusuke Sato, Naoko Mori

{"title":"Revision of lymph node classification in the Japanese Classification of Esophageal Cancer and its impact on definitive chemoradiotherapy for stage IV esophageal cancer: a single-institution retrospective study.","authors":"Tetsugaku Shinozaki, Yuki Wada, Satoshi Kumagai, Tasuku Kume, Noriko Takagi, Kenta Watanabe, Tamotsu Matsuhashi, Katsunori Iijima, Yushi Nagaki, Akiyuki Wakita, Yusuke Sato, Naoko Mori","doi":"10.1093/jrr/rrag083","DOIUrl":"https://doi.org/10.1093/jrr/rrag083","url":null,"abstract":"The 2022 revision of the Japanese Classification of Esophageal Cancer reclassified certain lymph node metastases previously considered locoregional as distant lymph node metastasis. Consequently, some patients previously diagnosed with stage IVA or III disease and treated with definitive chemoradiotherapy (dCRT) are now categorized as stage IVB disease with distant lymph node metastasis (IVB-Lym). We retrospectively evaluated the outcomes of dCRT in patients initially diagnosed with stage IVA or III disease and subsequently reclassified under the revised system. Among patients with esophageal cancer who underwent dCRT between January 2017 and December 2020 at our institution, 65 were reclassified as stage IVA (n = 19) or stage IVB-Lym (n = 46). Best overall response, overall survival (OS), progression-free survival (PFS) and chemotherapy-related adverse events (AEs) were evaluated. Complete or partial response was achieved in 84.2% of patients with stage IVA and 84.4% of those with stage IVB-Lym. The median OS and PFS were 26 and 8 months, respectively, in the stage IVA group and 35 and 9 months, respectively, in the stage IVB-Lym group. No significant differences were observed in OS (P = 0.69) or PFS (P = 0.67) between the two groups. The incidence and severity of AEs were generally comparable. No significant differences in efficacy or toxicity were observed between patients with reclassified stage IVB-Lym and those with stage IVA disease. These findings suggest that dCRT may be considered a treatment option for carefully selected patients with stage IVB-Lym following comprehensive clinical evaluation.","PeriodicalId":16922,"journal":{"name":"Journal of Radiation Research","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149039490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0