Journal of Radiation Research最新文献

{"title":"Correction to: Prostate dose escalation may positively impact survival in patients with clinically node-positive prostate cancer definitively treated by radiotherapy: surveillance study of the Japanese Radiation Oncology Study Group (JROSG).","authors":"","doi":"10.1093/jrr/rraf017","DOIUrl":"10.1093/jrr/rraf017","url":null,"abstract":"","PeriodicalId":16922,"journal":{"name":"Journal of Radiation Research","volume":" ","pages":"341-342"},"PeriodicalIF":1.9,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12100481/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144015688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Japanese national survey on IMRT/SBRT in 2023 by the JASTRO High-Precision External Beam Radiotherapy Group.","authors":"Masahide Saito, Shuichi Ozawa, Takafumi Komiyama, Masaki Kokubo, Yoshiyuki Shioyama, Yukinori Matsuo, Takashi Mizowaki, Tomoki Kimura, Hideyuki Harada, Hiroshi Igaki, Naoki Tohyama, Masahiko Kurooka, Mitsuhiro Nakamura, Yu Kumazaki, Hidekazu Suzuki, Hikaru Nemoto, Nagata Yasushi, Hiroshi Onishi","doi":"10.1093/jrr/rraf009","DOIUrl":"10.1093/jrr/rraf009","url":null,"abstract":"<p><p>The purpose of this study was to investigate the utilization and implementation of stereotactic body radiotherapy (SBRT) and intensity-modulated radiotherapy (IMRT) in Japan up to 2023. The survey was conducted by the Japanese Society for Radiation Oncology High-Precision External Beam Radiotherapy Group Subcommittee from December 2023 to February 2024. The study targeted patients treated with IMRT or SBRT between January 2021 and December 2022. A comprehensive web-based questionnaire was distributed to 880 facilities, with separate sections for radiation oncologists and medical physicists/radiotherapy technologists. A total of 360 facilities responded (response rate: 40.9%) for the section of radiation oncologists, and 405 facilities responded (response rate: 46.0%) for medical physicists/radiotherapy technologists, providing data on the implementation status, techniques, workload and challenges associated with IMRT and SBRT. Based on the responses in the section of radiation oncologists, IMRT was used in 68.6% of responding institutes, and SBRT in 87.8%. VMAT emerged as the most common IMRT technique (78.3%). The survey highlighted a high demand for medical physicists to perform IMRT (86.9%). Based on the responses in the section of medical physicists/radiotherapy technologists, 84.6% of the facilities that have not performed IMRT reported that the main reason was a lack of radiation oncologists. Furthermore, the survey also noted significant variations in prescribed doses and margin sizes across facilities, indicating the need for further standardization. High-precision radiation techniques such as IMRT and SBRT are getting popular, however, the facility requirements which mandate the presence of at least two radiation oncologists prevents IMRT from becoming more widespread in Japan.</p>","PeriodicalId":16922,"journal":{"name":"Journal of Radiation Research","volume":" ","pages":"234-252"},"PeriodicalIF":1.9,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12100480/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144026275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stereotactic body radiotherapy for central non-small cell lung cancer: risk analysis of radiation pneumonitis and bronchial dose constraints.","authors":"Nozomi Kita, Natsuo Tomita, Taiki Takaoka, Machiko Ukai, Dai Okazaki, Masanari Niwa, Akira Torii, Seiya Takano, Masanosuke Oguri, Akane Matsuura, Yuto Kitagawa, Yuta Eguchi, Akio Niimi, Akio Hiwatashi","doi":"10.1093/jrr/rraf016","DOIUrl":"10.1093/jrr/rraf016","url":null,"abstract":"<p><p>The present study investigated risk factors and bronchial dose constraints for symptomatic radiation pneumonitis (RP) in stereotactic body radiotherapy (SBRT) for central early-stage non-small cell lung cancer (NSCLC). We reviewed 245 patients with early-stage NSCLC treated with SBRT, and 78 patients with a tumor within 3 cm of the main or lobar bronchus were included in this study. Dose-volume histogram data were converted to a 4-fraction equivalent using the linear-quadratic model with an α/β value of 3. To examine the independent effects of dose parameters on grade ≥ 2 RP after adjusting for clinical factors, the Fine-Gray model with death as a competing risk was used for evaluation. With a median follow-up period of 44 months, the 4-year cumulative incidence of grade ≥ 2 and ≥ 3 RP was 22.5% and 8.5%, respectively. After adjustment for clinical factors, 6 bronchial dosimetric factors were significantly associated with grade ≥ 2 RP. Lung dosimetric factors were not significantly associated with grade ≥ 2 RP. Among significant dosimetric factors of the bronchus, bronchus V35Gy had the highest hazard ratio (HR) (HR 1.24, 95% CI 1.03-1.49, P = 0.027). The optimal threshold for bronchus V35Gy based on receiver operating characteristic curve analysis was 0.04 cc. The 4-year incidence of grade ≥ 2 RP in the bronchus V35Gy ≤ 0.04 cc vs. >0.04 cc groups was 15.7% vs. 37.0% (P = 0.036). In SBRT for central early-stage NSCLC, bronchus V35Gy < 0.04 cc is the definitive indicator for preventing grade ≥ 2 RP.</p>","PeriodicalId":16922,"journal":{"name":"Journal of Radiation Research","volume":" ","pages":"264-271"},"PeriodicalIF":1.9,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12100488/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144008635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Time-lapse imaging of cells in spatially fractionated X-ray fields using a mini beam as an alternative to accelerator-based sub-millimeter beams.","authors":"Kiichi Kaminaga, Hisanori Fukunaga, Eri Hirose, Ritsuko Watanabe, Keiji Suzuki, Kevin M Prise, Akinari Yokoya","doi":"10.1093/jrr/rraf020","DOIUrl":"10.1093/jrr/rraf020","url":null,"abstract":"<p><p>Due to the limited number of accelerator-based X-ray facilities worldwide that provide beams with an adjustable size, their application for radiobiological research purposes has been restricted. Thus, the development of alternative methods is of technical importance for investigating cell/tissue responses in spatially non-uniform radiation fields. In this study, we performed mini beam irradiation of cells using a lead (Pb) sub-milli-collimator as an alternative method to sub-millimeter beams. Also, we employed human cervical carcinoma HeLa cells and hTERT-immortalized fibroblast BJ-1 cells that express fluorescence ubiquitination-based cell-cycle indicators (FUCCI). Time-lapse imaging revealed differences in the behavior of HeLa and BJ-1 cells in spatially heterogeneous radiation fields; in the case of HeLa cells, G2/M phase-arrested cells in the cell population were clearly observed, distinguishing irradiated from non-irradiated cells at the sub-millimeter scale level. Our findings indicate that FUCCI can be useful as a biological dose indicator, depending on cell type, and Pb sub-milli-collimators show potential as a possible alternative to accelerator-based X-ray sub-millimeter beams for radiobiological research. The use of the collimators, unlike beamtime experiments in synchrotron facilities with the approval of the committee, is highly versatile and may be beneficial in preliminary studies in a normal laboratory environment.</p>","PeriodicalId":16922,"journal":{"name":"Journal of Radiation Research","volume":" ","pages":"318-328"},"PeriodicalIF":1.9,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12100484/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143998395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of a deep learning-based model to evaluate changes during radiotherapy using cervical cancer digital pathology.","authors":"Masaaki Goto, Yasunori Futamura, Hirokazu Makishima, Takashi Saito, Noriaki Sakamoto, Tatsuo Iijima, Yoshio Tamaki, Toshiyuki Okumura, Tetsuya Sakurai, Hideyuki Sakurai","doi":"10.1093/jrr/rraf004","DOIUrl":"10.1093/jrr/rraf004","url":null,"abstract":"<p><p>This study aims to create a deep learning-based classification model for cervical cancer biopsy before and during radiotherapy, visualize the results on whole slide images (WSIs), and explore the clinical significance of obtained features. This study included 95 patients with cervical cancer who received radiotherapy between April 2013 and December 2020. Hematoxylin-eosin stained biopsies were digitized to WSIs and divided into small tiles. Our model adopted the feature extractor of DenseNet121 and the classifier of the support vector machine. About 12 400 tiles were used for training the model and 6000 tiles for testing. The model performance was assessed on a per-tile and per-WSI basis. The resultant probability was defined as radiotherapy status probability (RSP) and its color map was visualized on WSIs. Survival analysis was performed to examine the clinical significance of the RSP. In the test set, the trained model had an area under the receiver operating characteristic curve of 0.76 per-tile and 0.95 per-WSI. In visualization, the model focused on viable tumor components and stroma in tumor biopsies. While survival analysis failed to show the prognostic impact of RSP during treatment, cases with low RSP at diagnosis had prolonged overall survival compared to those with high RSP (P = 0.045). In conclusion, we successfully developed a model to classify biopsies before and during radiotherapy and visualized the result on slide images. Low RSP cases before treatment had a better prognosis, suggesting that tumor morphologic features obtained using the model may be useful for predicting prognosis.</p>","PeriodicalId":16922,"journal":{"name":"Journal of Radiation Research","volume":" ","pages":"144-156"},"PeriodicalIF":1.9,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11932348/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143573142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Health risk perceptions of evacuees of Futaba town, Fukushima.","authors":"Bobby R Scott","doi":"10.1093/jrr/rraf008","DOIUrl":"10.1093/jrr/rraf008","url":null,"abstract":"","PeriodicalId":16922,"journal":{"name":"Journal of Radiation Research","volume":" ","pages":"199-201"},"PeriodicalIF":1.9,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11932341/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143557025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation of the safety of Radium-223 chloride in combination with external beam radiotherapy for bone metastases of prostate cancer.","authors":"Soichi Makino, Kazunari Miyazawa, Yoji Katsuoka, Takeru Ooe, Ken Aikawa, Akira Segawa, Hiroshi Kobayashi","doi":"10.1093/jrr/rraf002","DOIUrl":"10.1093/jrr/rraf002","url":null,"abstract":"<p><p>This study aimed to investigate the safety of combining radium-223 chloride (Ra-223) therapy with external beam radiation therapy (EBRT) for patients with multiple bone metastases from castration-resistant prostate cancer (CRPC), including lesions requiring urgent treatment such as those causing neurological symptoms due to spinal cord compression. We retrospectively analyzed data from patients with CRPC and bone metastases treated with Ra-223 therapy at our hospital between September 1, 2018, and December 31, 2023. Adverse events were evaluated using the Common Terminology Criteria for Adverse Events version 4.0. Of the 23 patients referred, data from 17 were included; 8 received concurrent Ra-223 therapy and EBRT, whereas others received only Ra-223 therapy. The median follow-up period was 20 months. Grade (G) 2 or higher adverse events occurred in seven patients (41.2%), and G 3 or higher in 2 (11.7%). None of the patients who received EBRT with fields involving the gastrointestinal tract experienced diarrhea, constipation, bleeding, perforation, or obstruction. Ra-223 therapy with EBRT did not increase adverse events compared with studies of Ra-223 therapy without EBRT. One case of G 5 Pneumocystis carinii pneumonia, likely because of steroid use for neurological symptoms and the patient's underlying diabetes mellitus, was noted. The effects of EBRT cannot be entirely excluded, so minimizing field size and dose is recommended when combining Ra-223 therapy and EBRT. Our findings indicate that concurrent Ra-223 therapy and EBRT could be safe for managing patients with symptomatic bone metastases and castration-resistant prostate cancer who require specialized treatment, provided sufficient attention is given to the field and the prescribed dose.</p>","PeriodicalId":16922,"journal":{"name":"Journal of Radiation Research","volume":" ","pages":"137-143"},"PeriodicalIF":1.9,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11932343/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143374308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Systemic inflammation response index predicts overall survival in patients undergoing stereotactic radiosurgery for brain metastasis from non-small cell lung cancer.","authors":"Ryosuke Matsuda, Tetsuro Tamamoto, Nobuyoshi Inooka, Shigeto Hontsu, Akihiro Doi, Ryosuke Maeoka, Tsutomu Nakazawa, Takayuki Morimoto, Kaori Yamaki, Sachiko Miura, Yudai Morisaki, Shohei Yokoyama, Masashi Kotsugi, Yasuhiro Takeshima, Fumiaki Isohashi, Ichiro Nakagawa","doi":"10.1093/jrr/rrae099","DOIUrl":"10.1093/jrr/rrae099","url":null,"abstract":"<p><p>This study aimed to evaluate the prognostic value of pre-treatment blood cell counts in patients with brain metastasis (BM) from non-small cell lung cancer (NSCLC) who were treated using linear accelerator (linac)-based stereotactic radiosurgery (SRS) and fractionated stereotactic radiotherapy (fSRT) with a micro-multileaf collimator. Between January 2011 and November 2022, 271 consecutive patients underwent linac-based SRS/fSRT for BM from NSCLC. Thirty patients with insufficient blood test data during this period were excluded from this analysis. Thirty-five patients with steroid intake at the time point of the blood test and 18 patients with higher C-reactive protein were excluded. Thus, 188 patients were eventually enrolled in this study. The median follow-up period after SRS/fSRT was 21 months (range: 0-121 months), and the median survival time after SRS/fSRT was 19 months. Neutrophil-lymphocyte ratio ≥ 1.90, lymphocyte-monocyte ratio ≤ 1.67 and systemic inflammation response index (SIRI) ≥ 2.95 were unfavorable predictors of prognosis for patients who underwent SRS/fSRT for BM from NSCLC. Cox proportional-hazard multivariate analysis revealed that the SIRI was independent prognostic factors for increased risk of death. Thus, simple, less expensive, and routinely performed pre-treatment blood cell count measurements such as SIRI can predict the overall survival of patients treated with SRS/fSRT for BM from NSCLC.</p>","PeriodicalId":16922,"journal":{"name":"Journal of Radiation Research","volume":" ","pages":"129-136"},"PeriodicalIF":1.9,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11932349/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143449375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of intermittent high-dose radon exposures on lung epithelial cells: proteomic analysis and biomarker identification.","authors":"Phawinee Subsomwong, Chutima Kranrod, Yuna Sakai, Krisana Asano, Akio Nakane, Shinji Tokonami","doi":"10.1093/jrr/rraf010","DOIUrl":"10.1093/jrr/rraf010","url":null,"abstract":"<p><p>Lung cancer is the most prevalent cancer worldwide, and radon exposure is ranked as the second risk factor after cigarette smoking. It has been reported that radon induces deoxyribonucleic acid damage and oxidative stress in cells. However, the protein profile and potential biomarkers for early detection of radon-induced lung cancer remain unknown. In this study, we aimed to investigate the effects of intermittent high-dose radon exposure on lung epithelial cells, analyze protein profiles and identify potential biomarkers for diagnosis of radon-related lung cancer. Human lung epithelial cells (A549) were exposed to radon (1000 Bq/m3) for 30 min daily for 7 days. Cell viability was measured using the WST-1 assay, and liquid chromatography-mass spectrometry proteomic analysis was performed. Differentially expressed proteins and gene ontology (GO) enrichment were analyzed. Our findings showed that intermittent high-radon exposure reduced A549 cell viability over time. Proteomic analysis identified proteins associated with stressed-induced apoptosis, mitochondrial adaptation, nuclear integrity and lysosomal degradation. These proteins are related to catabolism, stress response, gene expression and metabolic processes in the biological process of GO analysis. We highlighted specific proteins, including AKR1B1, CDK2, DAPK1, PRDX1 and ALHD2 with potential as biomarkers for radon-related lung cancer. In summary, intermittent high-dose radon exposure affects cellular adaptions of lung epithelial cells including stress-induced apoptosis, mitochondrial dysfunctions and immune regulation. The identified proteins may serve as diagnostic biomarkers or therapeutic targets for radon-related lung cancer.</p>","PeriodicalId":16922,"journal":{"name":"Journal of Radiation Research","volume":" ","pages":"107-114"},"PeriodicalIF":1.9,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11932336/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143634106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of confounding by smoking on cancer risk estimates in cohort studies of radiation workers: a simulation study.","authors":"Kazutaka Doi, Shinji Yoshinaga","doi":"10.1093/jrr/rraf012","DOIUrl":"10.1093/jrr/rraf012","url":null,"abstract":"<p><p>Previous studies on cohorts of radiation workers have provided valuable insights into the effects of low-dose-rate radiation; however, some concerns regarding the potential confounding effects of smoking have been expressed. Although some studies have collected smoking data and adjusted for this variable, their limited numbers and the presence of other confounders obscure the extent of the impact of smoking on their results. To address this, we conducted a simulation study to quantitatively evaluate the bias from confounding and modeling conditions, similar to actual epidemiological studies. Our analysis, based on data from Japanese radiation workers, indicated that not adjusting for smoking can lead to an overestimation of radiation effects by approximately 110%. This overestimation was relatively insensitive to sample size and dose distribution parameters, but varied with radiation and smoking risk, baseline smoking probability, and heterogeneity in baseline risk. Considering the simplified settings of this simulation study and the uncertainty of the estimates of Japanese radiation workers, our simulation results were consistent with those of the real-world epidemiological study. We also compared the results using Cox and Poisson regression models, ensuring that their modeling approaches were as similar as possible, and found minimal differences between them.</p>","PeriodicalId":16922,"journal":{"name":"Journal of Radiation Research","volume":" ","pages":"115-128"},"PeriodicalIF":1.9,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11932350/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143663818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}