Journal of Radiation Research最新文献_第2页

Impact of intermittent high-dose radon exposures on lung epithelial cells: proteomic analysis and biomarker identification.

IF 1.9 4区医学

Journal of Radiation Research Pub Date : 2025-03-24 DOI: 10.1093/jrr/rraf010

Phawinee Subsomwong, Chutima Kranrod, Yuna Sakai, Krisana Asano, Akio Nakane, Shinji Tokonami

{"title":"Impact of intermittent high-dose radon exposures on lung epithelial cells: proteomic analysis and biomarker identification.","authors":"Phawinee Subsomwong, Chutima Kranrod, Yuna Sakai, Krisana Asano, Akio Nakane, Shinji Tokonami","doi":"10.1093/jrr/rraf010","DOIUrl":"10.1093/jrr/rraf010","url":null,"abstract":"Lung cancer is the most prevalent cancer worldwide, and radon exposure is ranked as the second risk factor after cigarette smoking. It has been reported that radon induces deoxyribonucleic acid damage and oxidative stress in cells. However, the protein profile and potential biomarkers for early detection of radon-induced lung cancer remain unknown. In this study, we aimed to investigate the effects of intermittent high-dose radon exposure on lung epithelial cells, analyze protein profiles and identify potential biomarkers for diagnosis of radon-related lung cancer. Human lung epithelial cells (A549) were exposed to radon (1000 Bq/m3) for 30 min daily for 7 days. Cell viability was measured using the WST-1 assay, and liquid chromatography-mass spectrometry proteomic analysis was performed. Differentially expressed proteins and gene ontology (GO) enrichment were analyzed. Our findings showed that intermittent high-radon exposure reduced A549 cell viability over time. Proteomic analysis identified proteins associated with stressed-induced apoptosis, mitochondrial adaptation, nuclear integrity and lysosomal degradation. These proteins are related to catabolism, stress response, gene expression and metabolic processes in the biological process of GO analysis. We highlighted specific proteins, including AKR1B1, CDK2, DAPK1, PRDX1 and ALHD2 with potential as biomarkers for radon-related lung cancer. In summary, intermittent high-dose radon exposure affects cellular adaptions of lung epithelial cells including stress-induced apoptosis, mitochondrial dysfunctions and immune regulation. The identified proteins may serve as diagnostic biomarkers or therapeutic targets for radon-related lung cancer.","PeriodicalId":16922,"journal":{"name":"Journal of Radiation Research","volume":" ","pages":"107-114"},"PeriodicalIF":1.9,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11932336/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143634106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Postoperative hyperfractionated IMRT with weekly cisplatin for head and neck cancer: phase IIa trial.

IF 1.9 4区医学

Journal of Radiation Research Pub Date : 2025-03-24 DOI: 10.1093/jrr/rraf006

Shinya Hiraoka, Aya Nakajima, Masahiro Kikuchi, Motoo Nomura, Toshiyuki Imagumbai, Michio Yoshimura, Ryota Nakashima, Yo Kishimoto, Shogo Shinohara, Masaki Kokubo, Koichi Omori, Takashi Mizowaki

{"title":"Postoperative hyperfractionated IMRT with weekly cisplatin for head and neck cancer: phase IIa trial.","authors":"Shinya Hiraoka, Aya Nakajima, Masahiro Kikuchi, Motoo Nomura, Toshiyuki Imagumbai, Michio Yoshimura, Ryota Nakashima, Yo Kishimoto, Shogo Shinohara, Masaki Kokubo, Koichi Omori, Takashi Mizowaki","doi":"10.1093/jrr/rraf006","DOIUrl":"10.1093/jrr/rraf006","url":null,"abstract":"Postoperative chemoradiotherapy (POCRT) is the standard treatment for patients with head and neck squamous cell carcinoma (HNSCC) with high-risk features (positive microscopic margins and/or extranodal extensions). We hypothesized that dose escalation using hyperfractionation in intensity-modulated radiotherapy (HF-IMRT) improves POCRT outcomes; however, no prospective trial has assessed the feasibility of POCRT in HF. Therefore, we evaluated the feasibility of POCRT using HF-IMRT. HNSCC patients with positive microscopic margins and/or extranodal extension following surgery were included. HF-IMRT (73.6 Gy in 64 fractions twice daily) was administered along with cisplatin at 40 mg/m2 once a week for seven cycles during radiotherapy. The primary endpoint was the proportion of patients who completed treatment, which included the planned radiotherapy and the administration of ≥200 mg/m2 of cisplatin. Feasibility was defined as the proportion of patients who completed treatment >60% using a one-sided binomial test. Ten patients were registered between October 2021 and April 2023. One patient was excluded because of tumor recurrence before POCRT. The median follow-up time was 18.2 months, and the proportion of patients who completed treatment was 88.9%. The median total dose of cisplatin was 240 mg/m2. The percentage of patients with grade 3 acute non-hematological adverse events was 77.8%. No patient experienced grade 4 or higher acute adverse events or grade 3 or higher late adverse events. POCRT using HF-IMRT is feasible for achieving adequate cisplatin doses and safe radiotherapy in patients with HNSCC.","PeriodicalId":16922,"journal":{"name":"Journal of Radiation Research","volume":" ","pages":"167-175"},"PeriodicalIF":1.9,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11932334/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143557033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Independent verification system for intracavitary brachytherapy based on a reference plan and statistical model.

IF 1.9 4区医学

Journal of Radiation Research Pub Date : 2025-03-24 DOI: 10.1093/jrr/rraf007

Yuichi Akino, Fumiaki Isohashi, Takehiro Arimura, Shinichi Inoue, Hiroya Shiomi, Kazuhiko Hayashi, Shotaro Tatekawa, Keisuke Tamari, Takero Hirata, Masaki Nakai, Shinichi Shimizu, Kazuhiko Ogawa

{"title":"Independent verification system for intracavitary brachytherapy based on a reference plan and statistical model.","authors":"Yuichi Akino, Fumiaki Isohashi, Takehiro Arimura, Shinichi Inoue, Hiroya Shiomi, Kazuhiko Hayashi, Shotaro Tatekawa, Keisuke Tamari, Takero Hirata, Masaki Nakai, Shinichi Shimizu, Kazuhiko Ogawa","doi":"10.1093/jrr/rraf007","DOIUrl":"10.1093/jrr/rraf007","url":null,"abstract":"High dose rate (HDR) intracavitary brachytherapy (ICBT) with a remote afterloading system plays a vital role in the treatment of cervical cancer. We aimed to develop a new verification system for ICBT for cervical cancer and evaluate the feasibility for clinical plans (PlanClin) generated for different remote afterloaders, applicators and treatment techniques. In total, 517 PlansClin of patients were treated with Elekta 192Ir microSelectron HDR v2r. Reference plans (PlanRef) were generated for the ICBT applicators. An equation to predict total dwell time (Tdwell) of PlanClin was generated by evaluating the relationship between the volume receiving 100% of the prescribed dose (V100%) and the Tdwell. We also developed software to detect human errors in PlanClin by comparing parameters, including applicator and reference point geometries, dwell position and weight patterns and reference point dose, with those of PlanRef. Feasibility was evaluated for 83 PlanClin cases treated with the Elekta Flexitron remote afterloader and six ICBT plans with extra catheters (hybrid BT). The linear fitting function showed good agreement with the correlation between V100% and Tdwell. The developed equation accurately estimated the Tdwell of the PlanClin treated with the Flexitron with an accuracy of 0.26 ± 0.49%. Our system successfully detected intentional human errors including incorrect channel mapping, applicator tip offset, incorrect plan templates, an applicator digitization model and incorrect reference points. A verification system based on PlanRef and a statistical approach is feasible for the new remote afterloaders, applicators and hybrid BT techniques. This system contributes to the implementation of safe treatments.","PeriodicalId":16922,"journal":{"name":"Journal of Radiation Research","volume":" ","pages":"176-184"},"PeriodicalIF":1.9,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11932347/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143557032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Stereotactic arrhythmia radioablation for ventricular tachycardia: a review of clinical trials and emerging roles of imaging. 治疗室性心动过速的立体定向心律失常射频消融术：临床试验回顾与成像的新作用。

IF 1.9 4区医学

Journal of Radiation Research Pub Date : 2025-01-22 DOI: 10.1093/jrr/rrae090

Mariko Kawamura, Masafumi Shimojo, Fuminari Tatsugami, Kenji Hirata, Shohei Fujita, Daiju Ueda, Yusuke Matsui, Yasutaka Fushimi, Tomoyuki Fujioka, Taiki Nozaki, Akira Yamada, Rintaro Ito, Noriyuki Fujima, Masahiro Yanagawa, Takeshi Nakaura, Takahiro Tsuboyama, Koji Kamagata, Shinji Naganawa

{"title":"Stereotactic arrhythmia radioablation for ventricular tachycardia: a review of clinical trials and emerging roles of imaging.","authors":"Mariko Kawamura, Masafumi Shimojo, Fuminari Tatsugami, Kenji Hirata, Shohei Fujita, Daiju Ueda, Yusuke Matsui, Yasutaka Fushimi, Tomoyuki Fujioka, Taiki Nozaki, Akira Yamada, Rintaro Ito, Noriyuki Fujima, Masahiro Yanagawa, Takeshi Nakaura, Takahiro Tsuboyama, Koji Kamagata, Shinji Naganawa","doi":"10.1093/jrr/rrae090","DOIUrl":"10.1093/jrr/rrae090","url":null,"abstract":"Ventricular tachycardia (VT) is a severe arrhythmia commonly treated with implantable cardioverter defibrillators, antiarrhythmic drugs and catheter ablation (CA). Although CA is effective in reducing recurrent VT, its impact on survival remains uncertain, especially in patients with extensive scarring. Stereotactic arrhythmia radioablation (STAR) has emerged as a novel treatment for VT in patients unresponsive to CA, leveraging techniques from stereotactic body radiation therapy used in cancer treatments. Recent clinical trials and case series have demonstrated the short-term efficacy and safety of STAR, although long-term outcomes remain unclear. Imaging techniques, such as electroanatomical mapping, contrast-enhanced magnetic resonance imaging and nuclear imaging, play a crucial role in treatment planning by identifying VT substrates and guiding target delineation. However, challenges persist owing to the complex anatomy and variability in target volume definitions. Advances in imaging and artificial intelligence are expected to improve the precision and efficacy of STAR. The exact mechanisms underlying the antiarrhythmic effects of STAR, including potential fibrosis and improvement in cardiac conduction, are still being explored. Despite its potential, STAR should be cautiously applied in prospective clinical trials, with a focus on optimizing dose delivery and understanding long-term outcomes. Collaborative efforts are necessary to standardize treatment strategies and enhance the quality of life for patients with refractory VT.","PeriodicalId":16922,"journal":{"name":"Journal of Radiation Research","volume":" ","pages":"1-9"},"PeriodicalIF":1.9,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11753837/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142829092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of single- and multi-isocenter planning with Dynamic WaveArc for multiple brain metastases. 单、多等中心计划与动态WaveArc治疗多发性脑转移的比较。

IF 1.9 4区医学

Journal of Radiation Research Pub Date : 2025-01-22 DOI: 10.1093/jrr/rrae098

Mitsuaki Terabe, Takeshi Kamomae, Yuki Taniguchi, Hajime Ichikawa, Takehiro Yamada, Takayuki Miyachi, Risei Miyauchi, Junji Ito, Shunichi Ishihara

{"title":"Comparison of single- and multi-isocenter planning with Dynamic WaveArc for multiple brain metastases.","authors":"Mitsuaki Terabe, Takeshi Kamomae, Yuki Taniguchi, Hajime Ichikawa, Takehiro Yamada, Takayuki Miyachi, Risei Miyauchi, Junji Ito, Shunichi Ishihara","doi":"10.1093/jrr/rrae098","DOIUrl":"10.1093/jrr/rrae098","url":null,"abstract":"Dynamic WaveArc (DWA) is a technique used for continuous, non-coplanar volumetric-modulated arc therapy on the Vero4DRT platform. This study aimed to evaluate the application of single-isocenter DWA (SI-DWA) for treating multiple brain metastases by comparing dose distribution and irradiation time with multi-isocenter DWA (MI-DWA) through retrospective treatment planning. Treatment plans were developed for SI-DWA and MI-DWA in 14 cases with 3-5 brain metastases. Parameters assessed included target dose indices, such as conformity index (CI) of the planning target volume (PTV), volumes of normal brain excluding gross tumor volumes (GTVs) receiving a single dose equivalent of 14 Gy (V14), V30%, V20%, V10%, volumes of normal brain, including GTVs receiving a single dose equivalent of 12 Gy (V12), D2% for other organs at risk, and beam-on time. SI-DWA showed inferior CI, V14, and V12 values for lesions with PTV volumes <1 cc, whereas it performed equivalently to MI-DWA for lesions with PTV volumes ≥1 cc. SI-DWA resulted in higher volumes of normal brain receiving low doses compared to MI-DWA. SI-DWA exhibited significantly shorter beam-on times than MI-DWA. In conclusion, SI-DWA is an effective method for treating multiple brain metastases with PTV volumes ≥1 cc, offering an index of radiation-induced brain necrosis comparable with MI-DWA while allowing for shorter irradiation times.","PeriodicalId":16922,"journal":{"name":"Journal of Radiation Research","volume":" ","pages":"74-81"},"PeriodicalIF":1.9,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11753834/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142895561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Quantification of beam size impact on intensity-modulated proton therapy with robust optimization in head and neck cancer-comparison with intensity-modulated radiation therapy. 量化束大小对强度调制质子治疗的影响与稳健优化头颈部癌症-与强度调制放射治疗的比较。

IF 1.9 4区医学

Journal of Radiation Research Pub Date : 2025-01-22 DOI: 10.1093/jrr/rrae097

Hiromi Baba, Kenji Hotta, Ryo Takahashi, Kana Motegi, Yuya Sugama, Takeji Sakae, Hidenobu Tachibana

{"title":"Quantification of beam size impact on intensity-modulated proton therapy with robust optimization in head and neck cancer-comparison with intensity-modulated radiation therapy.","authors":"Hiromi Baba, Kenji Hotta, Ryo Takahashi, Kana Motegi, Yuya Sugama, Takeji Sakae, Hidenobu Tachibana","doi":"10.1093/jrr/rrae097","DOIUrl":"10.1093/jrr/rrae097","url":null,"abstract":"We assessed the effect of beam size on plan robustness for intensity-modulated proton therapy (IMPT) of head and neck cancer (HNC) and compared the plan quality including robustness with that of intensity-modulated radiation therapy (IMRT). IMPT plans were generated for six HNC patients using six beam sizes (air-sigma 3-17 mm at isocenter for a 70-230 MeV) and two optimization methods for planning target volume-based non-robust optimization (NRO) and clinical target volume (CTV)-based robust optimization (RO). Worst-case dosimetric parameters and plan robustness for CTV and organs-at-risk (OARs) were assessed under different scenarios, assuming a ± 1-5 mm setup error and a ± 3% range error. Statistical comparisons of NRO-IMPT, RO-IMPT and IMRT plans were performed. In regard to CTV-D99%, RO-IMPT with smaller beam size was more robust than RO-IMPT with larger beam sizes, whereas NRO-IMPT showed the opposite (P < 0.05). There was no significant difference in the robustness of the CTV-D99% and CTV-D95% between RO-IMPT and IMRT. The worst-case CTV coverage of IMRT (±5 mm/3%) for all patients was 96.0% ± 1.4% (D99%) and 97.9% ± 0.3% (D95%). For four out of six patients, the worst-case CTV-D95% for RO-IMPT (±1-5 mm/3%) were higher than those for IMRT. Compared with IMRT, RO-IMPT with smaller beam sizes achieved lower worst-case doses to OARs. In HNC treatment, utilizing smaller beam sizes in RO-IMPT improves plan robustness compared to larger beam sizes, achieving comparable target robustness and lower worst-case OARs doses compared to IMRT.","PeriodicalId":16922,"journal":{"name":"Journal of Radiation Research","volume":" ","pages":"65-73"},"PeriodicalIF":1.9,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11753836/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142895562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Real-world comparative outcomes and toxicities after definitive radiotherapy using proton beam therapy versus intensity-modulated radiation therapy for prostate cancer: a retrospective, single-institutional analysis. 质子束治疗与调强放射治疗前列腺癌明确放疗后的真实世界比较结果和毒性：一项回顾性、单一机构分析。

IF 1.9 4区医学

Journal of Radiation Research Pub Date : 2025-01-22 DOI: 10.1093/jrr/rrae065

Yojiro Ishikawa, Motohisa Suzuki, Hisashi Yamaguchi, Ichiro Seto, Masanori Machida, Yoshiaki Takagawa, Yusuke Azami, Yuntao Dai, Nor Shazrina Sulaiman, Satoshi Teramura, Yuki Narita, Takahiro Kato, Yasuyuki Kikuchi, Yasuo Fukaya, Masao Murakami

{"title":"Real-world comparative outcomes and toxicities after definitive radiotherapy using proton beam therapy versus intensity-modulated radiation therapy for prostate cancer: a retrospective, single-institutional analysis.","authors":"Yojiro Ishikawa, Motohisa Suzuki, Hisashi Yamaguchi, Ichiro Seto, Masanori Machida, Yoshiaki Takagawa, Yusuke Azami, Yuntao Dai, Nor Shazrina Sulaiman, Satoshi Teramura, Yuki Narita, Takahiro Kato, Yasuyuki Kikuchi, Yasuo Fukaya, Masao Murakami","doi":"10.1093/jrr/rrae065","DOIUrl":"10.1093/jrr/rrae065","url":null,"abstract":"This retrospective study aimed to compare the clinical outcomes of intensity-modulated radiation therapy (IMRT) and proton beam therapy (PBT). A total of 606 patients diagnosed with prostate cancer between January 2008 and December 2018 were included. Of these patients, 510 received PBT up to a dose of 70-78 Gy (relative biological effectiveness) and 96 patients received IMRT up to a dose of 70-78 Gy. The median follow-up period was 82 months (range: 32-140 months). Patients in the PBT group had significantly higher 7-year rates of biochemical relapse-free survival (bRFS) and disease-free survival (DFS) rates: 95.1% for PBT vs 89.9% for IMRT (P = 0.0271) and 93.1% for PBT vs 85.0% for IMRT (P = 0.0019). After matching analysis, 94 patients were assigned to both groups, and the PBT group showed significantly higher 7-year bRFS and DFS rates: 98.9% for PBT vs 89.7% for IMRT (P = 0.023) and 93.4% for PBT vs 84.6% for IMRT (P = 0.022), respectively. In the subgroup analysis of intermediate-risk patients, the PBT group showed a significantly higher 7-year bRFS rate (98.3% for PBT vs 90.5% for IMRT; P = 0.007). The V60 of the bladder in the PBT group (18.1% ± 10.1%) was higher than that in the IMRT group (14.4% ± 7.6%) (P = 0.024). This study found that the treatment outcomes of PBT potentially surpassed those of IMRT specifically concerning bRFS and DFS in real-world settings. However, it should be noted that attention is warranted for late bladder complication of PBT.","PeriodicalId":16922,"journal":{"name":"Journal of Radiation Research","volume":" ","pages":"39-51"},"PeriodicalIF":1.9,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11753839/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142983784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparative analysis of public concerns regarding treated water discharged from the Fukushima Daiichi Nuclear Power Station: perspectives before and after the initial release. 公众对福岛第一核电站污水排放关注的比较分析：首次排放前后的观点。

IF 1.9 4区医学

Journal of Radiation Research Pub Date : 2025-01-22 DOI: 10.1093/jrr/rrae102

Mengjie Liu, Hitomi Matsunaga, Makiko Orita, Yuya Kashiwazaki, Xu Xiao, Noboru Takamura

引用次数: 0

Characterization of acrylic phantom for use in quality assurance of BNCT beam output procedure. 用于 BNCT 光束输出程序质量保证的丙烯酸模型的特性。

IF 1.9 4区医学

Journal of Radiation Research Pub Date : 2025-01-22 DOI: 10.1093/jrr/rrae089

Nishiki Matsubayashi, Naonori Hu, Takushi Takata, Akinori Sasaki, Hiroaki Kumada, Satoshi Nakamura, Akihiko Masuda, Hiroki Tanaka

{"title":"Characterization of acrylic phantom for use in quality assurance of BNCT beam output procedure.","authors":"Nishiki Matsubayashi, Naonori Hu, Takushi Takata, Akinori Sasaki, Hiroaki Kumada, Satoshi Nakamura, Akihiko Masuda, Hiroki Tanaka","doi":"10.1093/jrr/rrae089","DOIUrl":"10.1093/jrr/rrae089","url":null,"abstract":"The accelerator-based boron neutron capture therapy (BNCT) system has been approved for specific cases covered by health insurance, and clinical trials for new cases in Japan are currently being conducted on other systems. Owing to the progress of accelerator-based BNCT, the operation of medical physics must be rendered more efficient. A water phantom is used for the quality assurance (QA) of the BNCT beam output procedure; however, a solid phantom is preferred for routine QA because of its ease of use. Additionally, because water phantoms cannot be readily used in some facilities owing to structural problems, solid phantoms are preferred for unified measurements at different facilities to compare beam outputs. In this study, we perform irradiation tests using an acrylic phantom and verify that an acrylic phantom can be used for QA. The distribution of thermal neutron flux and gamma-ray dose rate inside the acrylic phantom are evaluated through experiments and simulations. The results indicate that the acrylic phantom is suitable for routine QA and for comparing beam outputs among different systems. In the future, the same irradiation tests will be conducted at other facilities.","PeriodicalId":16922,"journal":{"name":"Journal of Radiation Research","volume":" ","pages":"10-15"},"PeriodicalIF":1.9,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11753832/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142675998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Radioactive contamination of southeast Abai oblast, Kazakhstan, from the Chinese nuclear weapons testing program at Lop Nor: an analytical review. 中国罗布泊核武器试验项目对哈萨克斯坦阿拜州东南部放射性污染的分析回顾。

IF 1.9 4区医学

Journal of Radiation Research Pub Date : 2025-01-22 DOI: 10.1093/jrr/rrae101

Alexandra Lipikhina, Richard Harbron, Kazbek Apsalikov, Yuliya Brait, Gani Yessilkanov, Vladimir Drozdovitch, Evgenia Ostroumova

{"title":"Radioactive contamination of southeast Abai oblast, Kazakhstan, from the Chinese nuclear weapons testing program at Lop Nor: an analytical review.","authors":"Alexandra Lipikhina, Richard Harbron, Kazbek Apsalikov, Yuliya Brait, Gani Yessilkanov, Vladimir Drozdovitch, Evgenia Ostroumova","doi":"10.1093/jrr/rrae101","DOIUrl":"10.1093/jrr/rrae101","url":null,"abstract":"Between 1949 and 1962 the Soviet Union performed atmospheric tests of nuclear weapons at the Semipalatinsk nuclear test site (SNTS) in Kazakhstan, resulting in widespread contamination of the surrounding region with radioactive fallout. Settlements in the southeast Abai oblast of Kazakhstan, close to the border with China, are not thought to have received significant fallout from the SNTS. There is, however, evidence that the study area, including Makanchi, Urdzhar and Taskesken villages, was contaminated by atmospheric nuclear tests performed by China at the Lop Nor NTS between 1964 and 1980. We identified the most reliable data indicating contamination from the Lop Nor tests from archive documents. Prompt sampling of soil performed in the area revealed elevated levels of total beta activity in the days and weeks following the Lop Nor tests. The highest activities were recorded following the thermonuclear tests in June 1967 and June 1973. Tooth enamel dosimetry using electron paramagnetic resonance methods suggests residents of the study area have been exposed to excess doses of 50-60 mGy but provides no information on the source and timing of exposure. Currently, evidence of contamination of the study area from nuclear weapons testing at Lop Nor is based on limited radiation measurement data. Therefore, work will continue on the search for archival data on radiological and meteorological monitoring carried out in the study area at the time of the Lop Nor testing campaign.","PeriodicalId":16922,"journal":{"name":"Journal of Radiation Research","volume":" ","pages":"24-30"},"PeriodicalIF":1.9,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11753833/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142983783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0