Journal of Radiation Research最新文献

{"title":"Correction to: Risk perception of the radiation health effects of decommissioning workers at Fukushima Daiichi Nuclear Power Plant.","authors":"","doi":"10.1093/jrr/rrag072","DOIUrl":"10.1093/jrr/rrag072","url":null,"abstract":"","PeriodicalId":16922,"journal":{"name":"Journal of Radiation Research","volume":" ","pages":"883"},"PeriodicalIF":2.1,"publicationDate":"2026-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13650716/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148706960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Image-guided moderately hypofractionated proton beam therapy for localized prostate cancer: 5-year outcomes of a phase II trial.","authors":"Takashi Iizumi, Hitoshi Ishikawa, Yuta Sekino, Motohiro Murakami, Keiichi Tanaka, Daichi Takizawa, Hirokazu Makishima, Yutaro Mori, Satoshi Kamizawa, Masashi Mizumoto, Toshiyuki Okumura, Hiroyoshi Suzuki, Hiroyuki Nishiyama, Hideyuki Sakurai","doi":"10.1093/jrr/rrag051","DOIUrl":"10.1093/jrr/rrag051","url":null,"abstract":"<p><p>The purpose of the present study is to confirm the efficacy and feasibility of moderately hypofractionated proton beam therapy (PBT) at a total dose of 63 Gy relative biological effectiveness (RBE) in 21 fractions for prostate cancer. This phase II clinical trial (PPS-002: UMIN 000017679) enrolled 125 men with histologically confirmed prostate cancer (cT1c-3aN0M0). The primary endpoint was grade ≥2 late gastrointestinal (GI) toxicities. Secondary endpoints included biochemical recurrence rates, clinical recurrence rates, overall survival (OS) and acute toxicities and late genitourinary (GU) toxicities. With a median follow-up period of 71.0 months (IQR: 60-84), the 5-year cumulative incidences of late grade 2 or higher GI and GU adverse events (AEs) were 3.3% and 8.1%, respectively. Biochemical recurrences were observed in three patients; no clinical recurrences occurred. The 5-year biochemical recurrence-free, clinical recurrence-free and OS rates were 97.6% (95% CI: 94.9-100.0), 100% and 97.5% (95% CI: 94.8-100.0), respectively. The long-term follow-up results of moderately hypofractionated PBT of 63 Gy (RBE) in 21 fractions confirmed low incidences of late AEs, successfully meeting the primary endpoint. Furthermore, the low incidence of tumor recurrence supports the overall safety and feasibility of this fractionation schedule.</p>","PeriodicalId":16922,"journal":{"name":"Journal of Radiation Research","volume":" ","pages":"779-786"},"PeriodicalIF":2.1,"publicationDate":"2026-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13650719/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148578969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of combination metformin and nintedanib therapy in a mouse model of irradiation-induced pulmonary fibrosis.","authors":"Ji-Hun Lee, Han-Bi Jeong, Eun-Seon Yoo, Na-Won Kim, Sun-Min Seo, Young-Jun Park, Yang-Kyu Choi, Jin-Hee Seo","doi":"10.1093/jrr/rrag057","DOIUrl":"10.1093/jrr/rrag057","url":null,"abstract":"<p><p>Radiation-induced lung injury, a well-recognized complication of thoracic radiotherapy, can progress to pulmonary fibrosis, sharing pathological features with idiopathic pulmonary fibrosis. Although nintedanib is widely used as an antifibrotic agent, the therapeutic benefit of combination strategies remains partially understood. Therefore, in this study, we aimed to evaluate the effects of combined metformin and nintedanib treatment in a mouse model of irradiation-induced lung fibrosis. Female C57BL/6 mice were subjected to localized irradiation of 90 Gy in the left lung and treated daily with metformin, nintedanib or both drugs for 6 weeks. Lung fibrosis was assessed using gross examination, hydroxyproline quantification, histopathological scoring and quantitative image analysis. Changes in fibrosis- and injury-related proteins were examined by western blotting, including transforming growth factor-β (TGF-β), a profibrotic cytokine; SMAD family member 7 (SMAD7), an inhibitory regulator of TGF-β signaling; and surfactant protein D (SP-D), a lung epithelial injury-associated protein. Nintedanib-containing treatments improved histological lung injury in irradiated mice, including reduced collagen deposition, low pathological scores and preserved air space structure. Hydroxyproline content was also lower in the combination treatment group than in the other groups. The nintedanib-containing treatments suppressed irradiation-induced upregulation of transforming growth factor-β expression, and SMAD7 expression was selectively upregulated following combined treatment. In addition, elevated SP-D level following irradiation was partially reduced following nintedanib administration. These findings suggest that combined metformin and nintedanib treatment may provide a broader protective profile against radiation-induced pulmonary fibrosis, particularly in association with SMAD7 upregulation, although further studies are required to clarify whether the combination provides significant advantages over nintedanib monotherapy.</p>","PeriodicalId":16922,"journal":{"name":"Journal of Radiation Research","volume":" ","pages":"715-723"},"PeriodicalIF":2.1,"publicationDate":"2026-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13650704/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148592377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Radiation-induced tumor following pencil beam scanning proton therapy for pediatric intracranial ependymoma: a pragmatic analysis of risk factors.","authors":"Eymeric Le Reun, Arturs Meijers, Maria Teresa Romero-Expósito, Ilya Kotov, Daniel J Indelicato, Damien Charles Weber","doi":"10.1093/jrr/rrag066","DOIUrl":"10.1093/jrr/rrag066","url":null,"abstract":"<p><p>Radiation-induced tumors (RITs) represent a rare yet serious long-term complication of ionizing radiation, particularly relevant in pediatric patients due to their long life expectancy. Proton therapy (PT) is widely used in children because of its favorable dose distribution compared to photon therapy. However, PT generates secondary neutrons that may contribute to RIT development. In a previously reported cohort of 119 children treated with pencil beam scanning (PBS) PT for intracranial ependymoma at the Paul Scherrer Institute (PSI), four RITs (3.4%) were observed after a median follow-up of 5.3 years. The present study aimed to explore potential risk factors for RITs within our institution's PBS-PT treatment protocol. A literature review identified one comparable cohort of 51 pediatric patients treated with commercial-like PBS-PT systems, in which no RITs were reported after a median follow-up of 5 years. In parallel, Monte Carlo simulations were performed to compare neutron production between the two PSI gantries. Neutron dose calculations revealed higher secondary neutron exposure associated with Gantry 1 compared to Gantry 2. Variability in system-specific neutron dose emissions may contribute to differential RIT risks. However, given the limited number of events, differences in follow-up duration, and potential confounding factors such as chemotherapy and treatment volumes, these findings should be considered hypothesis-generating. Continued optimization of PT delivery and long-term monitoring of pediatric patients treated with PBS-PT are required to establish causal relationship.</p>","PeriodicalId":16922,"journal":{"name":"Journal of Radiation Research","volume":" ","pages":"829-836"},"PeriodicalIF":2.1,"publicationDate":"2026-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13650720/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148794783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between rectal bleeding and radiation delivery time in intensity-modulated radiotherapy for localized prostate cancer: a preliminary study.","authors":"Nozomi Kita, Natsuo Tomita, Taiki Takaoka, Dai Okazaki, Masanari Niwa, Akira Torii, Seiya Takano, Masanosuke Oguri, Hikaru Tsuzuki, Machiko Ukai, Masahiro Sasaguchi, Takahiro Tsuchiya, Takahiro Yasui, Akio Hiwatashi","doi":"10.1093/jrr/rrag055","DOIUrl":"10.1093/jrr/rrag055","url":null,"abstract":"<p><p>The present study investigated the relationship between late grade ≥ 2 rectal bleeding and radiation delivery time in intensity-modulated radiotherapy (IMRT) for localized prostate cancer. We analyzed patients with localized prostate cancer treated with IMRT at our institution between July 2012 and February 2018, including only those treated with 74.8 Gy in 34 fractions (i.e. a fraction dose of 2.2 Gy). To evaluate the relationship between risk factors and late grade ≥ 2 rectal bleeding, we performed univariate analyses using the Gray test and the Fine-Gray model, and multivariate analysis using the Fine-Gray model. Additionally, propensity score matching was performed to adjust for confounding factors. A total of 142 cases were analyzed. The median follow-up period was 83 months. The 7-year cumulative incidence of late grade ≥ 2 rectal bleeding for the entire cohort was 5.7%. The group with shorter delivery time (≤150 s) had a significantly lower 7-year cumulative incidence of late grade ≥ 2 rectal bleeding compared to the group with longer delivery time (>150 s) (1.5% vs. 9.7%, P = 0.036). Multivariate analysis showed a trend toward an association between longer delivery time and increased late grade ≥ 2 rectal bleeding (hazard ratio 6.1, 95% confidence interval 0.78-48, P = 0.085). In the propensity score-matched cohort, the shorter delivery time group showed a significantly lower incidence of late grade ≥ 2 rectal bleeding (0% vs. 11.1%, P = 0.024). In IMRT for localized prostate cancer, shorter radiation delivery time may reduce the incidence of late grade ≥ 2 rectal bleeding.</p>","PeriodicalId":16922,"journal":{"name":"Journal of Radiation Research","volume":" ","pages":"796-802"},"PeriodicalIF":2.1,"publicationDate":"2026-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13650686/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148549215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Soil-to-plant transfer and radiological risk assessment of naturally occurring radionuclides in vegetables from Lay Gayint, Ethiopia.","authors":"Tadesse Abate Gobaw","doi":"10.1093/jrr/rrag070","DOIUrl":"10.1093/jrr/rrag070","url":null,"abstract":"<p><p>This study examines how naturally occurring radionuclides (40K, 226Ra, 228Ra) transfer from soil into cabbage and spinach grown in Lay Gayint woreda, Amhara Region, Ethiopia. Activity concentrations of radionuclides were measured in irrigation water (n = 15), soil (n = 20), and vegetable samples using HPGe gamma spectrometry. Mean soil concentrations were 625 ± 152 Bq·kg-1 for 40K, 89 ± 30 Bq·kg-1 for 226Ra, and 85 ± 31 Bq·kg-1 for 228Ra. Transfer factors (TFs) were highest for 40K (cabbage: 0.78 ± 0.07; spinach: 1.04 ± 0.13), followed by 226Ra (0.12 ± 0.01; 0.11 ± 0.02) and 228Ra (0.13 ± 0.03; 0.09 ± 0.01). A strong negative correlation was observed between clay content and TFs (r = -0.992 to -0.997, P < 0.001), indicating that higher clay content reduces plant uptake. Regression analysis showed that clay content explained over 98% of the variance in TFs. All radiological hazard indices (radium equivalent activity, external hazard index, internal hazard index) remained below global limits. Annual effective doses from vegetable consumption ranged from 0.01-0.06 mSv y-1 (cabbage) and 0.03-0.13 mSv y-1 (spinach), while the excess lifetime cancer risk (ELCR) reached up to 3.7 × 10-4. Although annual effective dose values fall within international recommendations, the ELCR is slightly elevated, suggesting minimal but nonnegligible radiological risk for consumers. This study provides key baseline data on radionuclide transfer in Ethiopian agriculture, useful for broader radiological risk assessment and management.</p>","PeriodicalId":16922,"journal":{"name":"Journal of Radiation Research","volume":" ","pages":"837-855"},"PeriodicalIF":2.1,"publicationDate":"2026-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13650721/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148955925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between high natural background radiation and cataract subtypes in female residents of Karunagappally, Kerala, India.","authors":"Athira Nandakumar, Ananthakrishnakurup Sreekumar, Anoop Bahuleyan, Mayumi Tsuji, Jayalekshmi Padmavathy Amma, Riyaz Ahammed, Raghu Ram K Nair, Chihaya Koriyama, Michiya Sasaki, Suminori Akiba, Junji Konishi, Keigo Endo","doi":"10.1093/jrr/rrag071","DOIUrl":"10.1093/jrr/rrag071","url":null,"abstract":"<p><p>Cataracts have reportedly been linked to radiation exposure. The goal of this study was to investigate the relationship between natural gamma-radiation exposure and the prevalence of cataracts among female inhabitants of Karunagappally, Kerala, India's high natural background radiation areas (HNBRA). From 2013 to 2014, a total of 840 women, whose lifetime natural radiation exposure had been estimated, underwent ophthalmic examinations and structured interviews. Five hundred and fifty women were from the control region (low- and medium dose areas), and 290 were from high natural background radiation area. The Lens Opacities Classification System was applied for grading cataracts. In the control region, 79 (14%) cortical, 10 (2%) posterior subcapsular and 24 (4%) nuclear cataracts were identified, whereas 54 (19%), 9 (3%) and 10 (4%) cases, respectively, were observed in high natural background radiation area. Cortical cataracts were significantly associated with cumulative radiation doses of 200 mGy or greater (odds ratio: 2.46; 95% confidence interval: 1.11-5.45) in logistic regression models adjusted for age, body mass index and family history of diabetes mellitus. After combining cortical and posterior subcapsular cataracts-subtypes more closely connected to radiation exposure-women exposed to more than 140 mGy in their lifetime, a reported threshold, exhibited a significantly increased risk (odds ratio: 1.25; 95% confidence interval: 1.00-1.56). The present study found a significant association between cortical and posterior subcapsular cataract prevalence and high natural background radiation exposure.</p>","PeriodicalId":16922,"journal":{"name":"Journal of Radiation Research","volume":" ","pages":"763-769"},"PeriodicalIF":2.1,"publicationDate":"2026-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13650688/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148969376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of X-ray and carbon-ion beam irradiation on pathological cardiac remodeling in mice.","authors":"Naoko Okano, Nozomi Furukawa, Norimichi Koitabashi, Hiromu Suda, Yukari Yoshida, Hideki Ishii, Tatsuya Ohno","doi":"10.1093/jrr/rrag075","DOIUrl":"10.1093/jrr/rrag075","url":null,"abstract":"<p><p>The objective of this study was to evaluate the effects of X-ray and carbon-ion (C-ion) beam irradiation on murine hearts under both normal and pathological conditions. Pathological cardiac hypertrophy was induced in mice by transverse aortic constriction (TAC) surgery. The control and TAC groups were irradiated with 30 Gy of X-rays or C-ion beams. Cardiac function was assessed every two weeks using echocardiography. Fibrosis, cardiomyocyte hypertrophy and Nppb expression were evaluated 8 weeks post-TAC. Irradiation had a limited effect on heart weight and function in control mice, although Nppb levels were elevated. TAC mice exhibited functional decline and increased fibrosis, which were improved by C-ions but not X-rays. Irradiation improved cardiac function and fibrosis in mice with heart failure, suggesting potential cardioprotective benefits. At the same physical dose, C-ion irradiation showed a trend toward improved cardiac function and reduced fibrosis; however, these differences were not significant compared with X-rays.</p>","PeriodicalId":16922,"journal":{"name":"Journal of Radiation Research","volume":" ","pages":"770-778"},"PeriodicalIF":2.1,"publicationDate":"2026-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13650709/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149012584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prospective feasibility study of diagnostic CT-based simulation-free palliative radiotherapy.","authors":"Takeshi Kashiwagi, Kiyonao Nakamura, Kazunori Tanaka, Tomohiro Kosuga, Kenta Fukumoto, Yuki Hanai, Shuji Ohtsu","doi":"10.1093/jrr/rrag056","DOIUrl":"10.1093/jrr/rrag056","url":null,"abstract":"<p><p>Conventional radiotherapy (RT) workflows require planning computed tomography (pCT) and treatment planning. However, these processes often take several days, leading to delays in RT initiation. Simulation-free radiotherapy (SFRT), which uses diagnostic CT (dCT) instead of pCT for treatment planning, may reduce the time from consultation-to-treatment delivery. However, the number of prospective studies conducted in Japan remains limited. This study prospectively evaluated the feasibility of SFRT in Japan. A single-center, single-arm prospective study (UMIN000054721) was performed in June 2024. This study included patients with vertebral metastases who were eligible for a single 8-Gy fraction. A dCT acquired within the last 56 days, without an immobilization device, and with an identifiable lesion, was required. The primary endpoint was the RT completion rate. The secondary endpoints included time in center (TIC), time from entering the consultation room to radiation beam-off, pain response and adverse events (AEs) at 4 and 12 weeks. Cone-beam CT (CBCT) verification was mandatory for patient setup. Five patients with six vertebral sites were enrolled. The RT completion rate was 100%. The mean TIC was 45 (range: 34-54) min. At 4 weeks, 25% of the patients presented with complete and partial pain responses. At 12 weeks, the complete response rate was 33%. None of the patients developed acute AEs. With appropriate patient selection and CBCT-guided verification, SFRT was feasible and safely implemented at a Japanese community hospital. Clinical trial registration: UMIN-CTR: UMIN000054721.</p>","PeriodicalId":16922,"journal":{"name":"Journal of Radiation Research","volume":" ","pages":"803-809"},"PeriodicalIF":2.1,"publicationDate":"2026-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13650689/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148579030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Attributable fraction of cardiac disease following radiotherapy among breast cancer survivors: a systematic review and meta-analysis.","authors":"Jeeyoung Lee, Eun Jung Park, Eria Bwogi, Nobuyuki Hamada, Sung Ryul Shim, Daeil Kwon, Won Jin Lee","doi":"10.1093/jrr/rrag073","DOIUrl":"10.1093/jrr/rrag073","url":null,"abstract":"<p><p>Radiotherapy (RT) is an integral component of cancer treatment; however, it can expose surrounding healthy tissues, including the heart, to ionizing radiation. This study aimed to evaluate the dose-response relationship between mean heart dose (MHD) and cardiac disease and to estimate the attributable burden among breast cancer survivors. PubMed and Embase were searched from inception to 31 January 2026 for studies reporting relative risks (RRs) per gray (Gy). A random-effects meta-analysis was used to pool dose-response estimates. The attributable fraction (AF) and population attributable fraction (PAF) were estimated using pooled dose-response coefficients and representative MHD values. Thirteen studies involving 16 446 breast cancer survivors were included. The pooled RR per Gy increase in MHD was 1.09 (95% confidence interval, 1.05-1.13), with no significant differences across treatment periods. At a representative MHD of 3.39 Gy, the AF among irradiated patients was estimated at 24.3%, indicating that one-quarter of cardiac events may be attributable to radiation exposure to the heart. Assuming a RT utilization of 52.7%, the corresponding PAF among breast cancer survivors was 14.4%. Although MHD decreased from 7.03 Gy before 2000 to 2.57 Gy thereafter, the AF declined from 38.9 to 21.6%. Over the same periods, despite a modest increase in RT utilization (51.1-55.3%), the PAF decreased from 24.5 to 13.2%. Despite these reductions, a measurable burden of cardiac disease remains attributable to radiation, underscoring the importance of minimizing cardiac dose among breast cancer survivors.</p>","PeriodicalId":16922,"journal":{"name":"Journal of Radiation Research","volume":" ","pages":"703-714"},"PeriodicalIF":2.1,"publicationDate":"2026-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13650711/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149012561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}