Journal of Radiation Research最新文献

{"title":"Improvement of deep learning-based dose conversion accuracy to a Monte Carlo algorithm in proton beam therapy for head and neck cancers.","authors":"Ryohei Kato, Noriyuki Kadoya, Takahiro Kato, Ryota Tozuka, Shuta Ogawa, Masao Murakami, Keiichi Jingu","doi":"10.1093/jrr/rraf019","DOIUrl":"10.1093/jrr/rraf019","url":null,"abstract":"<p><p>This study is aimed to clarify the effectiveness of the image-rotation technique and zooming augmentation to improve the accuracy of the deep learning (DL)-based dose conversion from pencil beam (PB) to Monte Carlo (MC) in proton beam therapy (PBT). We adapted 85 patients with head and neck cancers. The patient dataset was randomly divided into 101 plans (334 beams) for training/validation and 11 plans (34 beams) for testing. Further, we trained a DL model that inputs a computed tomography (CT) image and the PB dose in a single-proton field and outputs the MC dose, applying the image-rotation technique and zooming augmentation. We evaluated the DL-based dose conversion accuracy in a single-proton field. The average γ-passing rates (a criterion of 3%/3 mm) were 80.6 ± 6.6% for the PB dose, 87.6 ± 6.0% for the baseline model, 92.1 ± 4.7% for the image-rotation model, and 93.0 ± 5.2% for the data-augmentation model, respectively. Moreover, the average range differences for R90 were - 1.5 ± 3.6% in the PB dose, 0.2 ± 2.3% in the baseline model, -0.5 ± 1.2% in the image-rotation model, and - 0.5 ± 1.1% in the data-augmentation model, respectively. The doses as well as ranges were improved by the image-rotation technique and zooming augmentation. The image-rotation technique and zooming augmentation greatly improved the DL-based dose conversion accuracy from the PB to the MC. These techniques can be powerful tools for improving the DL-based dose calculation accuracy in PBT.</p>","PeriodicalId":16922,"journal":{"name":"Journal of Radiation Research","volume":" ","pages":"280-289"},"PeriodicalIF":1.9,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12100469/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144026063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advancing cell-free DNA as a biomarker of damage to heart caused by ionizing radiation.","authors":"Erin Wallisch, Aoy Tomita-Mitchell, Huan-Ling Liang, Aniko Szabo, Marek Lenarczyk, Anne Kwitek, Jennifer R Smith, Monika Tutaj, John E Baker","doi":"10.1093/jrr/rraf022","DOIUrl":"10.1093/jrr/rraf022","url":null,"abstract":"<p><p>Exposure to diagnostic and therapeutic radiation introduces risks for development of diseases later in life by causing DNA damage in cells. Currently, there is no clinical method for determining exposure risk caused by radiation toxicity to DNA. Cell-free DNA (cfDNA), a marker of DNA damage, is currently used to assess risk for long-term effects following organ transplantation, surgery and inflammation. The goal of our proposed study is to develop cfDNA as an early biomarker for assessing risk for cardiovascular disease and cancer from radiation exposure so that strategies to mitigate the damaging effects of medical radiation can be assessed. Hearts from male and female WAG/RijCmcr rats (n = 6-10/group) were exposed to increasing doses of X-radiation (50 mGy and 3.5 Gy). Blood was collected prior to and after (15 minutes-96 hours) irradiation, and cell-free plasma was prepared. Primers and probes were designed for quantitative analysis of sequences of mitochondria (12S rRNA) and nuclear (Gapdh) cfDNA present in rat plasma using quantitative reverse transcription polymerase chain reaction (RT-qPCR). Exposure of hearts to radiation increased nuclear and mitochondrial cfDNA in a dose-dependent manner. Three point five grays from X-radiation increase cfDNA for Gapdh in plasma after 1 hour with a 15.8-fold increase (P < 0.001) after 6 hours. The earliest time nuclear and mitochondrial cfDNA increases were detected in plasma was at 60 minutes following exposure to 3.5 Gy. cfDNA has potential to advance as a biomarker of exposure to medical doses of radiation in patients.</p>","PeriodicalId":16922,"journal":{"name":"Journal of Radiation Research","volume":" ","pages":"329-340"},"PeriodicalIF":1.9,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12100473/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143970658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to: Prostate dose escalation may positively impact survival in patients with clinically node-positive prostate cancer definitively treated by radiotherapy: surveillance study of the Japanese Radiation Oncology Study Group (JROSG).","authors":"","doi":"10.1093/jrr/rraf017","DOIUrl":"10.1093/jrr/rraf017","url":null,"abstract":"","PeriodicalId":16922,"journal":{"name":"Journal of Radiation Research","volume":" ","pages":"341-342"},"PeriodicalIF":1.9,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12100481/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144015688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stereotactic body radiotherapy for central non-small cell lung cancer: risk analysis of radiation pneumonitis and bronchial dose constraints.","authors":"Nozomi Kita, Natsuo Tomita, Taiki Takaoka, Machiko Ukai, Dai Okazaki, Masanari Niwa, Akira Torii, Seiya Takano, Masanosuke Oguri, Akane Matsuura, Yuto Kitagawa, Yuta Eguchi, Akio Niimi, Akio Hiwatashi","doi":"10.1093/jrr/rraf016","DOIUrl":"10.1093/jrr/rraf016","url":null,"abstract":"<p><p>The present study investigated risk factors and bronchial dose constraints for symptomatic radiation pneumonitis (RP) in stereotactic body radiotherapy (SBRT) for central early-stage non-small cell lung cancer (NSCLC). We reviewed 245 patients with early-stage NSCLC treated with SBRT, and 78 patients with a tumor within 3 cm of the main or lobar bronchus were included in this study. Dose-volume histogram data were converted to a 4-fraction equivalent using the linear-quadratic model with an α/β value of 3. To examine the independent effects of dose parameters on grade ≥ 2 RP after adjusting for clinical factors, the Fine-Gray model with death as a competing risk was used for evaluation. With a median follow-up period of 44 months, the 4-year cumulative incidence of grade ≥ 2 and ≥ 3 RP was 22.5% and 8.5%, respectively. After adjustment for clinical factors, 6 bronchial dosimetric factors were significantly associated with grade ≥ 2 RP. Lung dosimetric factors were not significantly associated with grade ≥ 2 RP. Among significant dosimetric factors of the bronchus, bronchus V35Gy had the highest hazard ratio (HR) (HR 1.24, 95% CI 1.03-1.49, P = 0.027). The optimal threshold for bronchus V35Gy based on receiver operating characteristic curve analysis was 0.04 cc. The 4-year incidence of grade ≥ 2 RP in the bronchus V35Gy ≤ 0.04 cc vs. >0.04 cc groups was 15.7% vs. 37.0% (P = 0.036). In SBRT for central early-stage NSCLC, bronchus V35Gy < 0.04 cc is the definitive indicator for preventing grade ≥ 2 RP.</p>","PeriodicalId":16922,"journal":{"name":"Journal of Radiation Research","volume":" ","pages":"264-271"},"PeriodicalIF":1.9,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12100488/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144008635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Japanese national survey on IMRT/SBRT in 2023 by the JASTRO High-Precision External Beam Radiotherapy Group.","authors":"Masahide Saito, Shuichi Ozawa, Takafumi Komiyama, Masaki Kokubo, Yoshiyuki Shioyama, Yukinori Matsuo, Takashi Mizowaki, Tomoki Kimura, Hideyuki Harada, Hiroshi Igaki, Naoki Tohyama, Masahiko Kurooka, Mitsuhiro Nakamura, Yu Kumazaki, Hidekazu Suzuki, Hikaru Nemoto, Nagata Yasushi, Hiroshi Onishi","doi":"10.1093/jrr/rraf009","DOIUrl":"10.1093/jrr/rraf009","url":null,"abstract":"<p><p>The purpose of this study was to investigate the utilization and implementation of stereotactic body radiotherapy (SBRT) and intensity-modulated radiotherapy (IMRT) in Japan up to 2023. The survey was conducted by the Japanese Society for Radiation Oncology High-Precision External Beam Radiotherapy Group Subcommittee from December 2023 to February 2024. The study targeted patients treated with IMRT or SBRT between January 2021 and December 2022. A comprehensive web-based questionnaire was distributed to 880 facilities, with separate sections for radiation oncologists and medical physicists/radiotherapy technologists. A total of 360 facilities responded (response rate: 40.9%) for the section of radiation oncologists, and 405 facilities responded (response rate: 46.0%) for medical physicists/radiotherapy technologists, providing data on the implementation status, techniques, workload and challenges associated with IMRT and SBRT. Based on the responses in the section of radiation oncologists, IMRT was used in 68.6% of responding institutes, and SBRT in 87.8%. VMAT emerged as the most common IMRT technique (78.3%). The survey highlighted a high demand for medical physicists to perform IMRT (86.9%). Based on the responses in the section of medical physicists/radiotherapy technologists, 84.6% of the facilities that have not performed IMRT reported that the main reason was a lack of radiation oncologists. Furthermore, the survey also noted significant variations in prescribed doses and margin sizes across facilities, indicating the need for further standardization. High-precision radiation techniques such as IMRT and SBRT are getting popular, however, the facility requirements which mandate the presence of at least two radiation oncologists prevents IMRT from becoming more widespread in Japan.</p>","PeriodicalId":16922,"journal":{"name":"Journal of Radiation Research","volume":" ","pages":"234-252"},"PeriodicalIF":1.9,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12100480/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144026275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Time-lapse imaging of cells in spatially fractionated X-ray fields using a mini beam as an alternative to accelerator-based sub-millimeter beams.","authors":"Kiichi Kaminaga, Hisanori Fukunaga, Eri Hirose, Ritsuko Watanabe, Keiji Suzuki, Kevin M Prise, Akinari Yokoya","doi":"10.1093/jrr/rraf020","DOIUrl":"10.1093/jrr/rraf020","url":null,"abstract":"<p><p>Due to the limited number of accelerator-based X-ray facilities worldwide that provide beams with an adjustable size, their application for radiobiological research purposes has been restricted. Thus, the development of alternative methods is of technical importance for investigating cell/tissue responses in spatially non-uniform radiation fields. In this study, we performed mini beam irradiation of cells using a lead (Pb) sub-milli-collimator as an alternative method to sub-millimeter beams. Also, we employed human cervical carcinoma HeLa cells and hTERT-immortalized fibroblast BJ-1 cells that express fluorescence ubiquitination-based cell-cycle indicators (FUCCI). Time-lapse imaging revealed differences in the behavior of HeLa and BJ-1 cells in spatially heterogeneous radiation fields; in the case of HeLa cells, G2/M phase-arrested cells in the cell population were clearly observed, distinguishing irradiated from non-irradiated cells at the sub-millimeter scale level. Our findings indicate that FUCCI can be useful as a biological dose indicator, depending on cell type, and Pb sub-milli-collimators show potential as a possible alternative to accelerator-based X-ray sub-millimeter beams for radiobiological research. The use of the collimators, unlike beamtime experiments in synchrotron facilities with the approval of the committee, is highly versatile and may be beneficial in preliminary studies in a normal laboratory environment.</p>","PeriodicalId":16922,"journal":{"name":"Journal of Radiation Research","volume":" ","pages":"318-328"},"PeriodicalIF":1.9,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12100484/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143998395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Health risk perceptions of evacuees of Futaba town, Fukushima.","authors":"Bobby R Scott","doi":"10.1093/jrr/rraf008","DOIUrl":"10.1093/jrr/rraf008","url":null,"abstract":"","PeriodicalId":16922,"journal":{"name":"Journal of Radiation Research","volume":" ","pages":"199-201"},"PeriodicalIF":1.9,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11932341/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143557025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of a deep learning-based model to evaluate changes during radiotherapy using cervical cancer digital pathology.","authors":"Masaaki Goto, Yasunori Futamura, Hirokazu Makishima, Takashi Saito, Noriaki Sakamoto, Tatsuo Iijima, Yoshio Tamaki, Toshiyuki Okumura, Tetsuya Sakurai, Hideyuki Sakurai","doi":"10.1093/jrr/rraf004","DOIUrl":"10.1093/jrr/rraf004","url":null,"abstract":"<p><p>This study aims to create a deep learning-based classification model for cervical cancer biopsy before and during radiotherapy, visualize the results on whole slide images (WSIs), and explore the clinical significance of obtained features. This study included 95 patients with cervical cancer who received radiotherapy between April 2013 and December 2020. Hematoxylin-eosin stained biopsies were digitized to WSIs and divided into small tiles. Our model adopted the feature extractor of DenseNet121 and the classifier of the support vector machine. About 12 400 tiles were used for training the model and 6000 tiles for testing. The model performance was assessed on a per-tile and per-WSI basis. The resultant probability was defined as radiotherapy status probability (RSP) and its color map was visualized on WSIs. Survival analysis was performed to examine the clinical significance of the RSP. In the test set, the trained model had an area under the receiver operating characteristic curve of 0.76 per-tile and 0.95 per-WSI. In visualization, the model focused on viable tumor components and stroma in tumor biopsies. While survival analysis failed to show the prognostic impact of RSP during treatment, cases with low RSP at diagnosis had prolonged overall survival compared to those with high RSP (P = 0.045). In conclusion, we successfully developed a model to classify biopsies before and during radiotherapy and visualized the result on slide images. Low RSP cases before treatment had a better prognosis, suggesting that tumor morphologic features obtained using the model may be useful for predicting prognosis.</p>","PeriodicalId":16922,"journal":{"name":"Journal of Radiation Research","volume":" ","pages":"144-156"},"PeriodicalIF":1.9,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11932348/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143573142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Residents of the towns in which the Fukushima Daiichi nuclear station is located express more worries about reputational damage than about the discharge of treated water itself.","authors":"Mengjie Liu, Hitomi Matsunaga, Makiko Orita, Yuya Kashiwazaki, Xu Xiao, Noboru Takamura","doi":"10.1093/jrr/rraf003","DOIUrl":"10.1093/jrr/rraf003","url":null,"abstract":"","PeriodicalId":16922,"journal":{"name":"Journal of Radiation Research","volume":" ","pages":"196-198"},"PeriodicalIF":1.9,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11932337/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143425667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A robust planning approach for respiratory motion in accelerated partial breast irradiation using volumetric modulated arc therapy.","authors":"Ryohei Yamauchi, Fumihiro Tomita, Satoshi Ishikura","doi":"10.1093/jrr/rraf011","DOIUrl":"10.1093/jrr/rraf011","url":null,"abstract":"<p><p>Accelerated partial breast irradiation (APBI) is an alternative treatment for early-stage breast cancer. This study aimed to evaluate the effectiveness of the virtual bolus (VB) method and robust planning against respiratory motion in volumetric modulated arc therapy (VMAT)-APBI. VMAT plans were generated with 30 Gy in 5 fractions for 16 patients. Four treatment plans were developed and compared: a standard optimization (SO) plan without robust methods, a pseudo-skin flash strategy using a 5 mm VB (with densities of 0.4 and 1.0 g/cm3, VB04 and VB10), and a robust optimization (RO) plan to minimize penalties in worst-case scenarios. The isocenter was shifted 1-5 mm in each translational direction in robust analysis, and perturbed dose calculations were performed. All dose constraints for the target in SO and VB plans were within acceptable limits, but the dose evaluation volume V95% in the RO plan was lower than in other plans (P < 0.05). The clinical target volume V95% of the RO plan was significantly higher than in VB04 and VB10 (P < 0.05). The RO plan showed the best performance for organs at risk, followed by SO and VB plans, which resulted in higher doses. The RO plan exhibited the smallest change (±2%) in dose distribution due to respiratory motion. By contrast, the SO plan lacked robustness owing to absence of sufficient fluence in the air surrounding the planning target volume outside of the skin surface. The RO plan offers superior target coverage, maximum dose, and robustness compared to SO and VB methods.</p>","PeriodicalId":16922,"journal":{"name":"Journal of Radiation Research","volume":" ","pages":"185-195"},"PeriodicalIF":1.9,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11932346/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143586093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}