Journal of Radiation Research最新文献_第2页

Stereotactic body radiotherapy with CyberKnife for liver-confined hepatocellular carcinoma: systematic review and meta-analysis. 射波刀立体定向放射治疗肝局限性肝细胞癌：系统回顾和荟萃分析。

IF 2 4区医学

Journal of Radiation Research Pub Date : 2025-09-23 DOI: 10.1093/jrr/rraf040

Takanori Abe, Mototaro Iwanaga, Mitsunobu Igari, Ryuta Hirai, Yu Kumazaki, Shin-Ei Noda, Shingo Kato

{"title":"Stereotactic body radiotherapy with CyberKnife for liver-confined hepatocellular carcinoma: systematic review and meta-analysis.","authors":"Takanori Abe, Mototaro Iwanaga, Mitsunobu Igari, Ryuta Hirai, Yu Kumazaki, Shin-Ei Noda, Shingo Kato","doi":"10.1093/jrr/rraf040","DOIUrl":"10.1093/jrr/rraf040","url":null,"abstract":"The purpose of this systematic review and meta-analysis was to evaluate the efficacy and safety of stereotactic body radiotherapy using CyberKnife (CK) for liver-confined hepatocellular carcinoma (HCC). A systematic review was performed on studies published between 2000 and 2024 that reported treatment outcomes including overall survival (OS), local control (LC), and complications. A literature search was performed using MEDLINE/PubMed with the following terms: ('Carcinoma, Hepatocellular'[MeSH Terms] OR 'hepatocellular carcinoma' OR 'HCC') AND ('CyberKnife' OR 'robotic radiosurgery'). Additional searches were conducted on Scopus and the Cochrane library using following terms: 'Hepatocellular carcinoma' AND 'CyberKnife.' A meta-analysis was performed to assess OS and LC using weighted random effects models. Five retrospective studies and one prospective study were included in the meta-analysis, comprising a total of 697 patients with a median follow-up duration was 31 months (range: 15-48 months). The pooled 3-year LC and OS rates were 82.5% (95% confidence interval [CI], 75.0%-90.0%) and 58.7% (95% CI, 47.2%-70.1%), respectively, which is comparable to previous reported outcomes for non-device-limited SBRT and similar to that of surgery and local ablative therapies. The incidence of radiation-induced liver disease was 4.3%-15.3%. Stereotactic body radiotherapy using CK appears to be an effective and well-tolerated treatment for liver-confined HCC. However, further prospective studies with standardized methodologies are warranted to establish solid evidence of its clinical utility.","PeriodicalId":16922,"journal":{"name":"Journal of Radiation Research","volume":" ","pages":"451-458"},"PeriodicalIF":2.0,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12460054/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144698852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

YTHDF2 alleviates the radioresistance of rectal cancer cells by targeting methylated MYC. YTHDF2通过靶向甲基化MYC减轻直肠癌细胞的放射耐药。

IF 2 4区医学

Journal of Radiation Research Pub Date : 2025-09-23 DOI: 10.1093/jrr/rraf043

Yeying Fang, Shijie Shang, Gang Chen, Dawei Chen, Jinming Yu

{"title":"YTHDF2 alleviates the radioresistance of rectal cancer cells by targeting methylated MYC.","authors":"Yeying Fang, Shijie Shang, Gang Chen, Dawei Chen, Jinming Yu","doi":"10.1093/jrr/rraf043","DOIUrl":"10.1093/jrr/rraf043","url":null,"abstract":"YTHDF2, a N6-methyladenosine (m6A) recognition protein, is involved in the occurrence and progression of various malignancies. The impact of YTHDF2 on the radiosensitivity of rectal cancer cells remains unclear. This study aimed to investigate the effect and potential mechanisms of YTHDF2 on radiotherapy sensitivity in rectal cancer. Acquired radioresistant colorectal cancer (CRC) cell lines (HCT-116-R and CX-1-R) were established through accumulative X-ray exposure. YTHDF2 was exogenously overexpressed or endogenously knocked down using lentivirus systems, and the radiosensitivity of the cells was analyzed both in vitro and in vivo. High-throughput transcriptome sequencing identified MYC as a downstream target of YTHDF2. RNA stability assays revealed that YTHDF2 facilitated the decay of MYC messenger (mRNA) through an m6A-dependent mechanism. Western blot analyses demonstrated that YTHDF2 modulated MYC expression and the Hippo signaling pathway, enhancing p-MST1/2, p-LATS1 and p-YAP levels while reducing nuclear YAP. Functional assays showed that YTHDF2 overexpression improved radiosensitivity by promoting radiation-induced apoptosis and G2/M phase arrest. MYC overexpression reversed these effects, suggesting a competitive regulatory relationship between YTHDF2 and MYC. These findings indicate that YTHDF2 modulates radiosensitivity through MYC and the Hippo signaling pathway. YTHDF2 enhances the radiosensitivity of rectal cancer cells by facilitating the degradation of MYC mRNA and activating the Hippo signaling pathway. Targeting YTHDF2 may provide a promising therapeutic strategy for overcoming radioresistance in rectal carcinoma.","PeriodicalId":16922,"journal":{"name":"Journal of Radiation Research","volume":" ","pages":"459-472"},"PeriodicalIF":2.0,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12460049/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144731914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of radiation protection by lead glasses for interventional radiology physicians wearing prescription glasses: considering dose reduction by prescription glasses excluding lead. 含铅眼镜对配戴处方眼镜的介入放射科医生的辐射防护评价：考虑不含铅的处方眼镜降低剂量。

IF 2 4区医学

Journal of Radiation Research Pub Date : 2025-09-23 DOI: 10.1093/jrr/rraf047

Ryota Shindo, Keisuke Yamamoto, Saya Ohno, Satoe Konta, Yohei Inaba, Masatoshi Suzuki, Masayuki Zuguchi, Koichi Chida

{"title":"Evaluation of radiation protection by lead glasses for interventional radiology physicians wearing prescription glasses: considering dose reduction by prescription glasses excluding lead.","authors":"Ryota Shindo, Keisuke Yamamoto, Saya Ohno, Satoe Konta, Yohei Inaba, Masatoshi Suzuki, Masayuki Zuguchi, Koichi Chida","doi":"10.1093/jrr/rraf047","DOIUrl":"10.1093/jrr/rraf047","url":null,"abstract":"The International Commission on Radiological Protection has reduced the occupational eye lens dose limit to 20 mSv/year. Interventional radiology (IR) physicians are frequently exposed to high levels of scattered X-rays, and radiation protection tools, including lead glasses, are used for minimizing exposure. However, the effectiveness of lead eyewear for radiation workers who wear prescription glasses (e.g. over-glasses-type eyewear) has not been comprehensively investigated. This study evaluated the shielding effectiveness of over-glasses-type eyewear worn over plastic prescription glasses through phantom experiments. Furthermore, the dose reduction provided by the plastic lenses and front frame of the prescription glasses (excluding lead) was assessed. The over-glasses-type eyewear demonstrated high shielding effectiveness, with average shielding rates of 0.72-0.74 and 0.74-0.80 for the left and right eyes, respectively, against radiation incident from the lower left oblique, as typically encountered in clinical settings. In contrast, the plastic lenses of prescription glasses provided <9% dose reduction when it irradiated with 80- and 120-kV X-rays, indicating minimal contribution to eye protection. The plastic front frame offered a 14% reduction at 80 kV and 11% at 120 kV. These findings suggest that the front frame of the prescription glasses contributes to photon attenuation and improves overall shielding. However, the improper fit of over-glasses-type eyewear may lead to gaps, compromising its shielding effectiveness. To minimize gaps and optimize protection, IR physicians should select over-glasses-type eyewear that fits securely over prescription glasses. Additionally, combining protective tools is essential for effective eye protection.","PeriodicalId":16922,"journal":{"name":"Journal of Radiation Research","volume":" ","pages":"486-495"},"PeriodicalIF":2.0,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12460050/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144835453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of stomatitis on pain relief and nutrition in palliative radiotherapy using quad shot: a prospective study. 口腔炎对姑息性放射治疗中疼痛缓解和营养影响的前瞻性研究。

IF 2 4区医学

Journal of Radiation Research Pub Date : 2025-09-23 DOI: 10.1093/jrr/rraf058

Osamu Tanaka, Kosuke Naganawa, Takashi Matsuzuka, Yuichi Ehara, Yasuhisa Hasegawa, Takuji Kiryu, Akira Ukai, Chiyoko Makita, Masayuki Matsuo

{"title":"Impact of stomatitis on pain relief and nutrition in palliative radiotherapy using quad shot: a prospective study.","authors":"Osamu Tanaka, Kosuke Naganawa, Takashi Matsuzuka, Yuichi Ehara, Yasuhisa Hasegawa, Takuji Kiryu, Akira Ukai, Chiyoko Makita, Masayuki Matsuo","doi":"10.1093/jrr/rraf058","DOIUrl":"https://doi.org/10.1093/jrr/rraf058","url":null,"abstract":"Quad Shot (QS) is effective in treating head and neck cancer; however, few prospective studies have been conducted in this direction. Further, no studies have investigated tumor pain and stomatitis pain separately. We prospectively investigated the efficacy and adverse events of QS in 11 patients with head and neck cancer who underwent QS at our hospital in Japan between 2018 and 2024. The QS method involved administering 3.7 Gy twice daily for 2 days, which was considered one course and provided thrice at an interval of 4 weeks. We assessed quality of life (QOL) scores, albumin levels, and numerical rating scale (NRS) scores for stomatitis and tumor pain before and after QS to evaluate changes in NRS. Eleven patients with advanced head and neck cancer received QS treatment: six patients underwent three courses, three underwent two, and two underwent one. There was no significant difference in QOL scores before and after QS, but albumin levels dropped significantly after QS. NRS due to stomatitis significantly worsened after QS, whereas NRS due to tumor significantly improved. Tumor size decreased and tumor NRS improved as the QS treatment duration increased. However, stomatitis was almost always present, and NRS scores for stomatitis increased significantly after treatment. In conclusion, QS can alleviate tumor pain but may worsen stomatitis. Therefore, stomatitis care should be emphasized during treatment. Furthermore, the decrease in albumin levels is likely due to stomatitis-induced decreased appetite; therefore, stomatitis management is also important for maintaining nutritional status.","PeriodicalId":16922,"journal":{"name":"Journal of Radiation Research","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145131205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessment of prognostic value and development of predictive model for prolonged lymphopenia in patients with glioblastoma following chemoradiotherapy. 胶质母细胞瘤放化疗后延长淋巴细胞减少的预后价值评估及预测模型的建立。

IF 2 4区医学

Journal of Radiation Research Pub Date : 2025-09-23 DOI: 10.1093/jrr/rraf045

Shuhei Takahashi, Kentaro Nishioka, Takashi Mori, Shigeru Yamaguchi, Yukitomo Ishi, Keiji Kobashi, Yoichi M Ito, Zen-Ichi Tanei, Hiromi Kanno-Okada, Shinya Tanaka, Hidefumi Aoyama

{"title":"Assessment of prognostic value and development of predictive model for prolonged lymphopenia in patients with glioblastoma following chemoradiotherapy.","authors":"Shuhei Takahashi, Kentaro Nishioka, Takashi Mori, Shigeru Yamaguchi, Yukitomo Ishi, Keiji Kobashi, Yoichi M Ito, Zen-Ichi Tanei, Hiromi Kanno-Okada, Shinya Tanaka, Hidefumi Aoyama","doi":"10.1093/jrr/rraf045","DOIUrl":"10.1093/jrr/rraf045","url":null,"abstract":"Lymphopenia during chemoradiotherapy (CRT) for glioblastoma has been shown to be a poor prognostic factor. However, the relationship between prolonged lymphopenia (PL) after CRT and prognosis remains unclear. This study aimed to explore the relationship between PL and glioblastoma prognosis and develop a predictive model for PL risk. We analyzed 87 patients with primary glioblastoma who underwent postoperative CRT with 60 Gy in 30 fractions of radiotherapy and temozolomide. PL was defined as grade 2 or higher lymphopenia 1 month after the completion of CRT. We conducted survival analysis, identified risk factors for PL, and developed a predictive model for PL risk. Of the 87 patients, 41 developed PL, and progression-free survival (PFS) was significantly shorter in the PL group (median 8.0 months vs 15.4 months, P = 0.003). However, there was no significant difference in overall survival between the two groups. PL was also a significant factor for shorter PFS in multivariable analysis (P = 0.040). Brain V20Gy (percentage of brain volume receiving ≥20 Gy), gross total resection (GTR), and preoperative Karnofsky performance status (KPS) were identified as significant risk factors for PL. The predictive model showed that the risk of PL could be predicted by brain V20Gy, sex, age, GTR and preoperative KPS. PL was identified as a PFS shortening factor. Our model suggests that reducing irradiated brain volume may help prevent PL and could potentially improve glioblastoma prognosis by preserving cancer immunity.","PeriodicalId":16922,"journal":{"name":"Journal of Radiation Research","volume":" ","pages":"542-550"},"PeriodicalIF":2.0,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12460052/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144835451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Three-dimensional reconstruction of a small piece of Ce-doped lithium glass scintillator of an optical fiber-based neutron detector using microcomputed tomography technique. 利用微计算机断层扫描技术对光纤中子探测器中一小片掺铈锂玻璃闪烁体进行三维重建。

IF 2 4区医学

Journal of Radiation Research Pub Date : 2025-09-23 DOI: 10.1093/jrr/rraf048

Akihisa Ishikawa, Mariko Segawa, Yosuke Toh, Kenichi Watanabe, Akihiko Masuda, Tetsuro Matsumoto, Atsushi Yamazaki, Sachiko Yoshihashi, Akira Uritani, Hideki Harano

{"title":"Three-dimensional reconstruction of a small piece of Ce-doped lithium glass scintillator of an optical fiber-based neutron detector using microcomputed tomography technique.","authors":"Akihisa Ishikawa, Mariko Segawa, Yosuke Toh, Kenichi Watanabe, Akihiko Masuda, Tetsuro Matsumoto, Atsushi Yamazaki, Sachiko Yoshihashi, Akira Uritani, Hideki Harano","doi":"10.1093/jrr/rraf048","DOIUrl":"10.1093/jrr/rraf048","url":null,"abstract":"An optical fiber-based neutron detector is a real-time neutron monitor for an intense neutron field. A small piece of neutron scintillator, such as Ce-doped lithium glass (Li-glass), used in the detector has a random shape with a grain size of 200-400 μm. This causes shape-dependent effects on the detector response. However, it is difficult to control or determine its shape due to its small size. Here we propose a technique to characterize the fine structure of a small piece of scintillator using a microcomputed tomography (CT) system. To verify accuracy, the mass calculated based on the density of Li-glass and the volume extracted from the obtained CT image was compared to the mass measured in advance using an electronic balance. In the obtained CT images, the fine shape of the small piece of Li-glass was clearly visible, and no false signals from the surrounding components were observed. The calculated mass was in good agreement with the measured value, however, when the total number of projection images was 2000, a slight underestimation was observed. This was mitigated by increasing the number of projection images, and the difference between the calculated and measured mass was 1.6% when the number of the projection images was 3141. This was equivalent to the uncertainty of the measured mass. The proposed technique will be useful when high accuracy is needed, such as for medical applications.","PeriodicalId":16922,"journal":{"name":"Journal of Radiation Research","volume":" ","pages":"563-569"},"PeriodicalIF":2.0,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12460048/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144731913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of rectal and bladder dose between retractor insertion and gauze packing in intracavitary brachytherapy for cervical cancer. 宫颈腔内近距离放疗中牵开器插入与纱布填充直肠及膀胱剂量的比较。

IF 2 4区医学

Journal of Radiation Research Pub Date : 2025-09-23 DOI: 10.1093/jrr/rraf042

Noriko Osaki, Takashi Soyano, Shinya Sutani, Hideki Matsumoto, Atsuya Takeda, Atsunori Yorozu

{"title":"Comparison of rectal and bladder dose between retractor insertion and gauze packing in intracavitary brachytherapy for cervical cancer.","authors":"Noriko Osaki, Takashi Soyano, Shinya Sutani, Hideki Matsumoto, Atsuya Takeda, Atsunori Yorozu","doi":"10.1093/jrr/rraf042","DOIUrl":"10.1093/jrr/rraf042","url":null,"abstract":"This study aimed to compare and verify the rectal and bladder doses of intracavitary brachytherapy (ICBT) using both rectal retractor (RR) and gauze packing (GP) in the same patients. A total of 37 patients who underwent ICBT using RR and GP for cervical cancer were included in this study. Rectal and bladder dose and volume data were compared with the RR and GP treatments in the same patients and the confounding factors were examined. When comparing RR and GP, the median and interquartile ranges for rectal D2cc were 2.8 (2.5-3.7) Gy with RR and 3.2 (2.7-3.8) Gy with GP. The median bladder D2cc was 4.9 (4.5-6.3) Gy with RR and 4.8 (3.9-5.4) Gy with GP. The Wilcoxon signed-rank test revealed that rectal doses were significantly lower with RR (P = 0.02), whereas bladder doses were significantly higher with RR (P < 0.001). Analysis of the correlation between the number of gauze pieces and the difference in rectal D2cc between GP and RR using Pearson's distribution revealed no significant correlation (R = -0.20, P = 0.22), as well as bladder D2cc between GP and RR also revealed no significant correlation (R = -0.20, P = 0.22). The number of gauze pieces did not necessarily correlate with a reduction in the rectal and bladder dose. In conclusion, rectal D2cc was lower with RR in image-guided brachytherapy for cervical cancer, whereas bladder D2cc was higher with RR than with GP.","PeriodicalId":16922,"journal":{"name":"Journal of Radiation Research","volume":" ","pages":"528-534"},"PeriodicalIF":2.0,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12460046/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144835452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical outcomes and prognostic factors of adjuvant radiotherapy for vulvar cancer: a Japanese Gynecologic Oncology Group nationwide survey study. 外阴癌辅助放疗的临床结果和预后因素：日本妇科肿瘤小组的一项全国性调查研究。

IF 2 4区医学

Journal of Radiation Research Pub Date : 2025-09-23 DOI: 10.1093/jrr/rraf050

Keisuke Tsuchida, Ken Ando, Noriyuki Okonogi, Mayuyo Mori, Masato Nishimura, Kenta Yoshida, Norihiro Sugino, Munetaka Takekuma, Aikou Okamoto, Tatsuya Ohno, Shin Nishio

{"title":"Clinical outcomes and prognostic factors of adjuvant radiotherapy for vulvar cancer: a Japanese Gynecologic Oncology Group nationwide survey study.","authors":"Keisuke Tsuchida, Ken Ando, Noriyuki Okonogi, Mayuyo Mori, Masato Nishimura, Kenta Yoshida, Norihiro Sugino, Munetaka Takekuma, Aikou Okamoto, Tatsuya Ohno, Shin Nishio","doi":"10.1093/jrr/rraf050","DOIUrl":"10.1093/jrr/rraf050","url":null,"abstract":"This study aimed to analyze the clinical outcomes and prognostic factors of postoperative adjuvant radiotherapy (RT) for vulvar cancer based on a retrospective Japanese nationwide survey. Data were collected from 108 institutions for patients diagnosed with vulvar cancer between January 2001 and December 2010. Patients with histologically confirmed squamous cell carcinoma, adenocarcinoma, or adenosquamous carcinoma who underwent curative surgery and adjuvant radiotherapy were included in this study. Survival outcomes were estimated using the Kaplan-Meier method, and prognostic factors were analyzed via univariate and multivariate models. A total of 139 patients were included, with a median follow-up of 44 months (range: 3-169). The 5-year overall survival (OS) rates (95% confidence interval [CI]) for stages I, II, III, and IV were 71.8% (50.8-92.8%), 61.3% (40.1-82.5%), 58.0% (45.8-70.2%), and 47.3% (27.5-67.1%), respectively. The corresponding 5-year cause-specific survival (CSS) rates (95% CI) for stages I, II, III, and IV were 71.8% (50.8-92.8%), 73.4% (53.0-93.8%), 62.2% (50.0-74.4%), and 47.3% (27.5-67.1%). Multivariate analysis identified age ≥70 years as an independent adverse prognostic factor for OS (hazard ratio [HR]: 1.848; 95% CI: 1.039-3.281; P = 0.042), while the presence of ≥2 inguinofemoral lymph node metastases was significantly associated with poorer CSS (HR: 2.179; 95% CI: 1.109-4.280; P = 0.030). Our analysis identified advanced age and a higher nodal burden as significant predictors of poorer survival outcomes in patients with vulvar cancer receiving postoperative adjuvant RT.","PeriodicalId":16922,"journal":{"name":"Journal of Radiation Research","volume":" ","pages":"551-562"},"PeriodicalIF":2.0,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12460047/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144958295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The impact of relationship between tumor volume and radiation dose on pain relief: are higher doses needed for larger tumors? 肿瘤体积与辐射剂量关系对疼痛缓解的影响：肿瘤越大需要更高的剂量吗？

IF 2 4区医学

Journal of Radiation Research Pub Date : 2025-09-23 DOI: 10.1093/jrr/rraf039

Kohsei Yamaguchi, Tetsuo Saito, Tomohiko Matsuyama, Yoshiyuki Fukugawa, Takahiro Watakabe, Shigeo Yamada, Natsuo Oya

{"title":"The impact of relationship between tumor volume and radiation dose on pain relief: are higher doses needed for larger tumors?","authors":"Kohsei Yamaguchi, Tetsuo Saito, Tomohiko Matsuyama, Yoshiyuki Fukugawa, Takahiro Watakabe, Shigeo Yamada, Natsuo Oya","doi":"10.1093/jrr/rraf039","DOIUrl":"10.1093/jrr/rraf039","url":null,"abstract":"The influences of tumor volume and total radiation dose on pain relief outcomes have not been fully investigated. We investigated potential correlations between gross tumor volume (GTV), biologically effective dose (BED) and pain relief in patients receiving radiation therapy (RT) for painful tumors. As a secondary analysis of a three-center prospective observational study of 302 patients who received RT for painful tumors, patients treated at an academic hospital were analyzed. We used the Brief Pain Inventory short form to evaluate pain intensity and interference in patients' lives. We collected the Brief Pain Inventory and analgesic data at baseline and 1, 2, 3, 6, 9 and 12 months after the start of RT. Pain responses were assessed using the International Consensus Endpoint. The Fine and Gray models were used for univariable and multivariable analyses, to estimate the impact of clinical factors on pain response and pain progression. In total, 153 (59%) of the 258 patients experienced a pain response, and 45 (17%) patients experienced pain progression. In the univariable and multivariable analyses, GTV and BED did not significantly associate with pain response or pain progression. Furthermore, no significant interaction between GTV and BED was reported in terms of pain response or pain progression after adjusting for covariates. The impact of BED on pain response and pain progression did not vary according to the GTV.","PeriodicalId":16922,"journal":{"name":"Journal of Radiation Research","volume":" ","pages":"520-527"},"PeriodicalIF":2.0,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12460043/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144682765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tumor shrinkage after simultaneous proton therapy for multiple hepatocellular carcinomas. 多发性肝细胞癌同步质子治疗后肿瘤缩小。

IF 2 4区医学

Journal of Radiation Research Pub Date : 2025-09-23 DOI: 10.1093/jrr/rraf044

Hikaru Niitsu, Masashi Mizumoto, Yinuo Li, Taisuke Sumiya, Keiichiro Baba, Motohiro Murakami, Masatoshi Nakamura, Toshiki Ishida, Takashi Iizumi, Takashi Saito, Haruko Numajiri, Hirokazu Makishima, Kei Nakai, Yoshiko Oshiro, Hideyuki Sakurai

{"title":"Tumor shrinkage after simultaneous proton therapy for multiple hepatocellular carcinomas.","authors":"Hikaru Niitsu, Masashi Mizumoto, Yinuo Li, Taisuke Sumiya, Keiichiro Baba, Motohiro Murakami, Masatoshi Nakamura, Toshiki Ishida, Takashi Iizumi, Takashi Saito, Haruko Numajiri, Hirokazu Makishima, Kei Nakai, Yoshiko Oshiro, Hideyuki Sakurai","doi":"10.1093/jrr/rraf044","DOIUrl":"10.1093/jrr/rraf044","url":null,"abstract":"There are no reports on shrinkage of multiple hepatocellular carcinomas (HCCs) after simultaneous treatment with radiotherapy. The purpose of the study was to examine the relationship between tumor shrinkage and treatment outcomes for several HCCs irradiated simultaneously using proton beam therapy (PBT). The subjects were 46 patients with multiple HCCs (95 lesions) who received PBT between January 2008 and December 2018. Overall survival (OS), local control (LC) and complete+partial response (CR + PR) rates were determined using the Kaplan-Meier method. The median follow-up period was 29.2 months and the 3-year OS was 50.3%. For the 95 lesions, the 3-year LC rate was 90.4% and the CR + PR rate was 85.2% at 3 years. Three combination protocols (referred to as A, B and C) were used for different lesions in the same patient: A (66 Gray (Gy) Relative biological effectiveness (RBE) in 10 fractions (fr))-B (72.6 Gy(RBE) in 22 fr) (22 lesions), A-C (74 Gy(RBE) in 37 fr) (15 lesions) and B-C (2 lesions). The 1-year CR + PR rates were 75.8% for A and 56.4% for B in A-B cases (P = 0.14), and 62.5% for A and 57.1% for C in A-C cases (P = 0.35). In the B-C group, there was only one patient with 2 lesions. The lesion treated with the B protocol reached CR + PR, while that treated with the C protocol did not reach CR + PR. These results show that some cases can have differences in tumor shrinkage after concurrent PBT for multiple HCCs, and that there is no significant relationship between dose and tumor shrinkage.","PeriodicalId":16922,"journal":{"name":"Journal of Radiation Research","volume":" ","pages":"535-541"},"PeriodicalIF":2.0,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12460042/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144690610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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