暴露于喷射中子活化 31SiO2 微粒子的 Wistar 大鼠器官中的内辐射剂量估算:国际多中心研究的首批结果。

IF 1.9 4区 医学 Q2 BIOLOGY
Valeriy Stepanenko, Hitoshi Sato, Andrey Kaprin, Nariaki Fujimoto, Almagul Kushugulova, Sergey Ivanov, Peter Shegay, Viktoria Bogacheva, Alexey Petukhov, Kassym Zhumadilov, Evgenia Ostroumova, Hiroshi Yasuda, Noriyuki Kawano, Megu Ohtaki, Satoru Endo, Aya Sakaguchi, Laura Chulenbayeva, Nurislam Mukhanbetzhanov, Masaharu Hoshi
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引用次数: 0

摘要

中子激活的 31Si 是一种几乎纯粹的 β 辐射体,是广岛和长崎原子弹爆炸后早期以残余放射性形式产生的短寿命放射性核素 (包括 β γ 辐射体 56Mn)之一。这些放射性核素的内照射生物效应特征是科学讨论和研究的主题。本出版物介绍了实验用 Wistar 大鼠受到喷射中子激活的 31SiO2 微粒子照射后的内辐射剂量数据。内辐射剂量可根据其数值有条件地分为三组。研究发现,大鼠器官/组织因暴露于初始活度为 3.2 × 107 Bq 的喷射 31SiO2 微粒子而受到的内辐射剂量升高值在 10 至 120 mGy 之间(眼睛、肺、皮肤、胃、空肠、大肠)。中等剂量值在 1.9 至 3.7 mGy 之间(气管、食道、回肠)。肾脏、睾丸、血液、小脑、心脏、肝脏、大脑、膀胱、脾脏和胸腺受到的剂量最小(从 0.11 到 0.94 mGy)。所获得的数据对于解释正在进行和计划进行的 31SiO2 微粒子生物实验的结果非常重要,这些数据与以前公布的关于发射β-伽马射线的 56MnO2 中子激活微粒子造成的生物效应特征的数据进行了比较。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Internal radiation dose estimates in organs of Wistar rats exposed to sprayed neutron-activated 31SiO2 microparticles: first results of international multicenter study.

Neutron-activated 31Si is an almost pure beta emitter and is one of the short-lived radionuclides, including beta-gamma emitter 56Mn, which were created in a form of residual radioactivity in the early period after the atomic bombing of Hiroshima and Nagasaki. The features of the biological effects of internal irradiation by these radionuclides are a subject of scientific discussions and research. The publication presents data on internal radiation doses in experimental Wistar rats that were exposed to sprayed neutron-activated microparticles of 31SiO2. Doses of internal radiation could be conditionally divided into three groups according to their values. It has been found that elevated values of internal radiation doses in rats' organs/tissues as a result of exposure to sprayed 31SiO2 microparticles with initial activity of 3.2 × 107 Bq varied from 10 to 120 mGy (eyes, lungs, skin, stomach, jejunum, large intestine). The moderate dose values were in the range from 1.9 to 3.7 mGy (trachea, esophagus, ileum). The smallest doses were received by the kidney, testis, blood, cerebellum, heart, liver, cerebrum, bladder, spleen and thymus (from 0.11 to 0.94 mGy). The obtained data are important for interpreting the results of ongoing and planned biological experiments with 31SiO2 microparticles-in comparison with the previously published data on features of biological effects caused by beta-gamma emitting 56MnO2 neutron-activated microparticles.

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来源期刊
CiteScore
3.60
自引率
5.00%
发文量
86
审稿时长
4-8 weeks
期刊介绍: The Journal of Radiation Research (JRR) is an official journal of The Japanese Radiation Research Society (JRRS), and the Japanese Society for Radiation Oncology (JASTRO). Since its launch in 1960 as the official journal of the JRRS, the journal has published scientific articles in radiation science in biology, chemistry, physics, epidemiology, and environmental sciences. JRR broadened its scope to include oncology in 2009, when JASTRO partnered with the JRRS to publish the journal. Articles considered fall into two broad categories: Oncology & Medicine - including all aspects of research with patients that impacts on the treatment of cancer using radiation. Papers which cover related radiation therapies, radiation dosimetry, and those describing the basis for treatment methods including techniques, are also welcomed. Clinical case reports are not acceptable. Radiation Research - basic science studies of radiation effects on livings in the area of physics, chemistry, biology, epidemiology and environmental sciences. Please be advised that JRR does not accept any papers of pure physics or chemistry. The journal is bimonthly, and is edited and published by the JRR Editorial Committee.
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