Dosimetric commissioning of a high-resolution CMOS 2D detector array for patient-specific QA of single-isocenter multi-target VMAT stereotactic radiosurgery.

IF 1.9 4区 医学 Q2 BIOLOGY
Ching-Ling Teng, Shih-Chi Lin, Dale Michael Lovelock, Seng Boh Lim
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引用次数: 0

Abstract

Stereotactic radiosurgery (SRS) using the single-isocenter-multiple-target (SIMT) technique by volumetric modulated arc therapy is increasingly popular for treating multiple brain metastases. However, the complex nature of SIMT SRS necessitates rigorous patient-specific quality assurance (PSQA). This study presents a multi-institutional dosimetric commissioning of a high-resolution complementary metal oxide semiconductor (CMOS) 2D detector array, the myQA SRS device for SIMT SRS PSQA. Basic dosimetric properties such as dose-rate, field-size, energy and angular dependencies were characterized for the CMOS detectors. Additionally, gamma index analyses were performed between the measured dose and the films for nine simulated and clinical plans. The results showed that the CMOS detector was dose-rate, field-size, energy and beam-angle dependent. Specific to SIMT SRS, angular dependence on gantry rotations was invariant to couch rotations but was sensitive to off-isocenter distances. With appropriate dose calibration and angular corrections, myQA SRS showed a high dosimetric correlation with films. The average gamma index pass rates were 99.9 ± 0.03% and 99.2 ± 1.1% at 3%/2 mm/10%thr(global) and 1 mm/1%/10%thr(local) criteria, respectively. The average dose difference between myQA SRS and films was 0.4 ± 1.3%. In conclusion, the CMOS 2D detector array has demonstrated its potential as a reliable tool for PSQA for SIMT SRS. The excellent dosimetric agreement with the films was consistent in multiple institutions, further validating the dosimetric accuracy and reproducibility. It provides a timely alternative to film dosimetry for commissioning and quality assurance.

高分辨率 CMOS 2D 探测器阵列的剂量调试,用于单中心多靶点 VMAT 立体定向放射手术的患者特异性质量保证。
利用容积调制弧治疗的单异中心多靶点(SIMT)技术进行的立体定向放射外科(SRS)在治疗多发性脑转移瘤方面越来越受欢迎。然而,SIMT SRS 的复杂性要求严格的患者特异性质量保证(PSQA)。本研究介绍了用于 SIMT SRS PSQA 的高分辨率互补金属氧化物半导体(CMOS)二维探测器阵列 myQA SRS 设备的多机构剂量测定调试情况。对 CMOS 探测器的剂量率、场大小、能量和角度依赖性等基本剂量学特性进行了鉴定。此外,还对九种模拟和临床计划的测量剂量和胶片进行了伽马指数分析。结果表明,CMOS 探测器与剂量率、磁场大小、能量和光束角度有关。具体到 SIMT SRS,龙门架旋转的角度依赖性与床旋转无关,但对偏离中心的距离很敏感。通过适当的剂量校准和角度修正,myQA SRS 显示出与胶片的高度剂量相关性。在3%/2 mm/10%thr(全局)和1 mm/1%/10%thr(局部)标准下,伽马指数平均合格率分别为99.9 ± 0.03%和99.2 ± 1.1%。myQA SRS 和胶片的平均剂量差为 0.4 ± 1.3%。总之,CMOS 二维探测器阵列已证明其作为 SIMT SRS PSQA 可靠工具的潜力。在多个机构中,与胶片的剂量测定结果一致,进一步验证了剂量测定的准确性和可重复性。它为试运行和质量保证提供了薄膜剂量测定的及时替代方案。
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来源期刊
CiteScore
3.60
自引率
5.00%
发文量
86
审稿时长
4-8 weeks
期刊介绍: The Journal of Radiation Research (JRR) is an official journal of The Japanese Radiation Research Society (JRRS), and the Japanese Society for Radiation Oncology (JASTRO). Since its launch in 1960 as the official journal of the JRRS, the journal has published scientific articles in radiation science in biology, chemistry, physics, epidemiology, and environmental sciences. JRR broadened its scope to include oncology in 2009, when JASTRO partnered with the JRRS to publish the journal. Articles considered fall into two broad categories: Oncology & Medicine - including all aspects of research with patients that impacts on the treatment of cancer using radiation. Papers which cover related radiation therapies, radiation dosimetry, and those describing the basis for treatment methods including techniques, are also welcomed. Clinical case reports are not acceptable. Radiation Research - basic science studies of radiation effects on livings in the area of physics, chemistry, biology, epidemiology and environmental sciences. Please be advised that JRR does not accept any papers of pure physics or chemistry. The journal is bimonthly, and is edited and published by the JRR Editorial Committee.
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