Journal of Drug Delivery Science and Technology最新文献

{"title":"Recent advancements in construction and application of MOFs-based drug delivery systems","authors":"Wei Jin,&nbsp;Hao Chen,&nbsp;Zewei Wang,&nbsp;Fengli Chen,&nbsp;Duqiang Luo,&nbsp;Hongde An","doi":"10.1016/j.jddst.2026.108082","DOIUrl":"10.1016/j.jddst.2026.108082","url":null,"abstract":"<div><div>Metal-organic frameworks (MOFs) have emerged as a highly promising and versatile class of nanomaterials for advanced drug delivery applications. This review comprehensively summarizes the recent advancements in the utilization of MOFs as innovative nanocarriers for therapeutic agents, with a specific purpose to establish a clear framework that critiques how specific MOF properties are rationally engineered to solve defined drug delivery challenges. It also highlights the strategies for enhancing the biocompatibility, colloidal stability, and targeting efficiency of MOFs through various surface engineering and ligand modification techniques, providing a critical synthesis that maps these design principles to their efficacy in advanced applications, including combination cancer therapy and the delivery of biomacromolecules, areas where MOFs offer distinct advantages over conventional nanocarriers. Finally, the review discusses the current challenges regarding long-term toxicity, large-scale synthesis, and in vivo efficacy that must be addressed to successfully translate MOF-based drug delivery systems from the laboratory to the clinic, while also providing an outlook on future research directions.</div></div>","PeriodicalId":15600,"journal":{"name":"Journal of Drug Delivery Science and Technology","volume":"118 ","pages":"Article 108082"},"PeriodicalIF":4.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146172257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Encouraging formulation and assessment of mizolastine-loaded nanosponges for management of atopic dermatitis in animal model","authors":"Nerwied Tarek Bondok ,&nbsp;Ghada Ahmed El-Emam ,&nbsp;Marwa Abd El-kader ,&nbsp;Thanaa M. Borg","doi":"10.1016/j.jddst.2026.108061","DOIUrl":"10.1016/j.jddst.2026.108061","url":null,"abstract":"<div><div>Mizolastine (MZL), is a second-generation nonsedating antihistamine with anti-inflammatory effects, that relieves rhinitis, conjunctivitis, and atopic dermatitis (AD). Nanosponges (NS) are colloidal systems that offer sustained drug release and extended skin residence for topical application. The goal of the study was to create a unique MZL-NS that would improve AD symptoms. By using emulsion solvent diffusion method, MZL-NS were effectively developed, characterized, and optimized using a 3² full factorial design with two independent variables: the concentration of Polyvinyl alcohol (PVA) (A) and the amount of Eudragit® (E100) (B) at three different levels. Before the optimized formulation was incorporated into a gel base matrix, more <em>in vitro</em>–<em>ex vivo</em> studies were conducted. Stability study, in vitro, ex vivo, and in vivo evaluations of NS-gel (containing the improved formulation (F6)) were then conducted to determine its significant efficacy as a topical nanostructured system for managing AD symptoms. Imperatively, the results support an expected effective therapeutic activity of the F6-gel formulation against 2,4-Dinitrofluorobenzene-induced AD in rats. Rats treated with F6-gel showed a significant decrease in mast cell infiltration, a significant reduction in immunomarker expression levels in their ears, suppressing the up-regulation of total serum Immunoglobulin E (IgE) levels to a greater extent, as well as a restoration of skin thickness and integrity. MZL-NS could be considered a promising stable sustained-release topical nanoparticulate system for the management of atopic dermatitis.</div></div>","PeriodicalId":15600,"journal":{"name":"Journal of Drug Delivery Science and Technology","volume":"118 ","pages":"Article 108061"},"PeriodicalIF":4.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146172289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Silk fibroin: features, production methods and medical applications","authors":"Ayşegül Yıldız,&nbsp;N. Başaran Mutlu-Ağardan,&nbsp;Füsun Acartürk","doi":"10.1016/j.jddst.2026.108066","DOIUrl":"10.1016/j.jddst.2026.108066","url":null,"abstract":"<div><div>Silk fibroin is a biopolymer of natural origin which could be obtained simply and affordably from silkworm cocoon using various extraction agents. It has many advantages such as biocompatibility, biodegradability, low immunogenicity, low toxicity, high water vapor permeability, high mechanical resistance, etc. Owing to those properties, it attracts attention in many fields such as tissue engineering, cancer treatment, enzyme immobilization, wound healing, and the treatment of inflammatory bowel disease. This review outlines the properties and production methods of silk fibroin, and comprehensively summarizes its biomedical applications, including tissue engineering (bone, cartilage, musculoskeletal, skin, eardrum, dental, tracheal, tendon and ligament, cardiac, ocular, hepatic, spinal cord and intervertebral disc), artificial skin substitutes, cancer therapy, wound healing, inflammatory bowel disease and drug delivery systems.</div></div>","PeriodicalId":15600,"journal":{"name":"Journal of Drug Delivery Science and Technology","volume":"118 ","pages":"Article 108066"},"PeriodicalIF":4.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146172261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biological properties of iron oxide nanoparticles and bone morphogenetic protein 2 functionalized biomaterials for bone tissue engineering, from a molecular perspective: A review","authors":"Maria Arias-Acevedo ,&nbsp;Edwin B. Patiño ,&nbsp;Claudia Patricia Ossa-Orozco ,&nbsp;Sandra S. Arango-Varela ,&nbsp;Diego Uribe","doi":"10.1016/j.jddst.2026.108110","DOIUrl":"10.1016/j.jddst.2026.108110","url":null,"abstract":"<div><div>When a disease or trauma causes bone defects larger than 2 cm or compromising more than 50% of the bone circumference, strategies that mimic tissue functions while regeneration occurs are required. Current clinical alternatives present significant limitations, such as the reduced volume of bone available for grafts, donor site morbidity, elevated surgical risks, and in some cases, the need for a second intervention to remove implants. These factors complicate the recovery process, prolong patient rehabilitation, and increase costs, becoming a public health problem. Given this scenario, bone tissue engineering has gained relevance in biomedical research, thanks to the possibility of modifying biomaterials at physical, chemical, and biological levels to promote cell adhesion, proliferation, and differentiation, while ensuring adequate cytocompatibility and avoiding pro-inflammatory responses. Among the most promising strategies is the incorporation of iron oxide nanoparticles (IONPs) and bone morphogenetic protein 2 (BMP-2). This review presents the current state of research on biomaterials that integrate IONPs and BMP-2, and analyzes the associated biological responses. Additionally, it discusses the main signaling pathways involved, such as Wntβ−catenin, BMP, and integrin-mediated adhesion, as well as the key role of immunomodulation in the success of these therapies.</div></div>","PeriodicalId":15600,"journal":{"name":"Journal of Drug Delivery Science and Technology","volume":"118 ","pages":"Article 108110"},"PeriodicalIF":4.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146172291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advanced strategies for surface modifications of manganese oxide nanoparticles for cancer diagnosis and therapy","authors":"Sadeen Metib Alsarayreh ,&nbsp;Mohammed Ali Dheyab ,&nbsp;Ramzun M. Ramli ,&nbsp;Azlan Abdul Aziz ,&nbsp;Saleh T. Alanezi ,&nbsp;Nazila Oladzadabbasabadi ,&nbsp;Mehran Ghasemlou","doi":"10.1016/j.jddst.2026.108079","DOIUrl":"10.1016/j.jddst.2026.108079","url":null,"abstract":"<div><div>Manganese oxide nanoparticles (MnOx NPs) are a versatile class of redox-active nanomaterials that are attracting increasing attention for applications in cancer diagnosis and therapy due to their exceptional properties such as high specific surface area, a high fraction of surface atoms, biocompatibility, and excellent redox properties. This review provides a comprehensive analysis of fundamental principles in the design, synthesis, and surface modification of MnOx-based NPs. We examine the most recent progress regarding the sustainable production of MnOx NPs, whilst also highlighting their applications in critical environmental and energy related fields. Recent advances in nanotechnology have yielded a significant number of MnOx nanostructured carriers that can deliver drugs to specific cancerous sites with high efficiency. As a result, we provide a focused and critical overview of the diagnostic and therapeutic potential of surface-engineered MnOx NPs. Finally, some unsettled issues and potential opportunities in this promising field are proposed, which we hope will contribute to shape the developmental road of MnOx nanoplatforms. This review can act as roadmap to guide researchers toward concepts that are essential for developing next-generation MnOx-based multifunctional nanoplatforms.</div></div>","PeriodicalId":15600,"journal":{"name":"Journal of Drug Delivery Science and Technology","volume":"118 ","pages":"Article 108079"},"PeriodicalIF":4.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146172292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"RVG29-functionalized, resveratrol-loaded chitosan nanoparticles: An inflammation-responsive brain-targeted strategy for bipolar disorder therapy","authors":"Xianxiang Zeng ,&nbsp;Xiaozi Lu ,&nbsp;Fa Guo ,&nbsp;Hu Lin ,&nbsp;Yifan Xiong ,&nbsp;Jin Li ,&nbsp;Weiwei Zhu","doi":"10.1016/j.jddst.2026.108085","DOIUrl":"10.1016/j.jddst.2026.108085","url":null,"abstract":"<div><div>Targeted nanomedicine for bipolar disorder (BD) remains a major therapeutic challenge due to limited blood-brain barrier (BBB) penetration and the lack of site-specific drug delivery strategies addressing neuroinflammation. Herein, we report a novel, multifunctional nanoplatform: RVG29-functionalized, ROS- and inflammation-responsive chitosan nanoparticles (Chitosan-RVG29@RES) for precision delivery of the neuroprotective polyphenol, resveratrol. Exploiting ionic gelation and thiol-maleimide chemistry, chitosan nanoparticles (∼120 nm) were decorated with RVG29 to facilitate receptor-mediated BBB transcytosis. Advanced materials characterization (XRD, FTIR, Raman, UV-Vis, TGA, TEM, DLS, and zeta potential) confirmed uniform nanoscale morphology, stable peptide conjugation, and molecular-level encapsulation, resulting in a stimuli-responsive, chemically integrated nanocarrier. The nanoplatform was specifically designed to respond to the oxidative stress and mild acidosis characteristic of inflamed neural microenvironments, enabling the controlled and localized release of resveratrol. <em>In vitro</em>, BV2 microglial cells showed enhanced uptake, robust ROS scavenging, mitochondrial stabilization, and downregulation of pro-inflammatory cytokines (TNF-α, IL-6, iNOS). <em>In vivo</em>, LPS-induced bipolar disorder rodent models demonstrated enhanced brain accumulation, restoration of endogenous antioxidants (SOD, GSH, CAT), attenuation of neuroinflammatory mediators, improved behavioural phenotypes, and negligible systemic toxicity. Histopathology analysis confirmed the preservation of major organs and colon tissue architecture, highlighting the biocompatibility and safety of the system. Overall, this study addresses the central research question of whether disease-microenvironment–responsive nanocarriers can improve brain-targeted therapy for inflammation-driven bipolar disorder. The study exemplifies how rational materials chemistry design can transform neurotherapeutic delivery, merging structural innovation, stimuli-responsiveness, and translational neuroprotection into a single platform.</div></div>","PeriodicalId":15600,"journal":{"name":"Journal of Drug Delivery Science and Technology","volume":"118 ","pages":"Article 108085"},"PeriodicalIF":4.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146172282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Macro/microstructured quercetin-loaded poly(lactide-co-glycolide) scaffolds for neural tissue engineering","authors":"Gianni Pecorini ,&nbsp;Ilaria Degano ,&nbsp;Nicole Alì ,&nbsp;Massimiliano Leigheb ,&nbsp;Simona Braccini ,&nbsp;Paolo Del Magro ,&nbsp;Andrea Corti ,&nbsp;Elisabetta Ferraro ,&nbsp;Dario Puppi","doi":"10.1016/j.jddst.2026.108089","DOIUrl":"10.1016/j.jddst.2026.108089","url":null,"abstract":"<div><div>Modern brain tissue engineering strategies can exploit the antioxidant and anti-inflammatory properties of quercetin (Que) by encapsulating it in a biodegradable polymer to develop bioactive scaffolds. The aim of this research was to develop Que-loaded poly(lactide-<em>co</em>-glycolide) (PLGA) scaffolds structured at different scales using either solution-extrusion additive manufacturing (AM) or electrospinning. The 3D scaffolds produced by AM had a macroporous structure and micropores distributed throughout the fiber cross-section. The electrospun meshes were composed of microfibers with a diameter of around 2 μm that could be deposited on top of 3D scaffolds to form a dual-scale structure. Que was successfully loaded into the two types of PLGA systems with high encapsulation efficiency (&gt;90%). <em>In vitro</em> release of Que was only detected in the case of electrospun meshes but not for 3D scaffolds and dual-scale constructs due to their lower specific surface area and the partial degradation of the flavonoid in phosphate buffer saline (PBS) at 37 °C. Que loading had a significant impact on both the glass transition temperature of the polymer in 3D scaffolds and the tensile properties of electrospun meshes. Flavonoid loading or device morphology did not affect the <em>in vitro</em> degradation of the polymer, whose molecular weight was reduced by half in 8 weeks in PBS at 37 °C. The meshes had similar radical scavenging activity to free Que, while the antioxidant activity of the dual-scale scaffolds was in-between those of 3D scaffolds and meshes. Cell culture experiments on microglia cells confirmed that Que loaded on PLGA meshes maintains its anti-inflammatory activity. The obtained results demonstrate the potential of the developed devices as surgical bioactive scaffolds for treating brain damage.</div></div>","PeriodicalId":15600,"journal":{"name":"Journal of Drug Delivery Science and Technology","volume":"118 ","pages":"Article 108089"},"PeriodicalIF":4.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146172372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of carrier particle size on the performance of adhesive mixtures for inhalation","authors":"Kyrre Thalberg ,&nbsp;Maja Tagesson ,&nbsp;Lars Asking ,&nbsp;Mårten Svensson","doi":"10.1016/j.jddst.2026.108048","DOIUrl":"10.1016/j.jddst.2026.108048","url":null,"abstract":"<div><div>Despite being subject to a multitude of investigations, the effect of carrier particle size on the performance of adhesive mixtures for inhalation is still not well understood. This study, involving three differently sized lactose carriers, all with the regular ‘tomahawk’ particle shape, aims to provide fundamental insight into this topic. Fine particle fraction (FPF) data for binary formulations with 2 % budesonide, blended both in the Diosna high shear mixer and in a Turbula blender, are analyzed in terms of the applied mixing force and mixing energy (ME). For high shear blended formulations, the results clearly indicate that the mixing force acting between adhesive units is directly proportional to the mass of the carrier particle. Formulations produced at different mixing times and speeds display a linear decrease in FPF when plotted against ME, with similar slopes for the different carriers, in particular as regard the relative decrease in FPF. The inhaler device affects the magnitude of the FPF, but not the relative decrease rate. Interestingly, formulations blended in the Turbula mixer show an opposite behavior, with increasing FPF at a longer mixing times/energies. This points to different mechanisms playing the key role in the two mixing regimes. In conclusion, the applied mixing energy, with carrier particle mass included in the equation, seems to play a crucial role for both mixers.</div></div>","PeriodicalId":15600,"journal":{"name":"Journal of Drug Delivery Science and Technology","volume":"118 ","pages":"Article 108048"},"PeriodicalIF":4.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146172328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Smart MOF-integrated biopolymeric hydrogel systems as a novel strategy for sustained anticancer drug delivery","authors":"Zubda Ilyas ,&nbsp;Aneela Javed ,&nbsp;Waheed Miran ,&nbsp;Muhammad Bilal Khan Niazi ,&nbsp;Usman Liaqat","doi":"10.1016/j.jddst.2026.108049","DOIUrl":"10.1016/j.jddst.2026.108049","url":null,"abstract":"<div><div>The development of localized and sustained drug delivery systems remains a critical challenge in glioblastoma therapy due to rapid drug clearance and systemic toxicity. In this study, a smart hybrid delivery platform was engineered by integrating amino-functionalized iron-based metal–organic frameworks (NH₂-MIL-88B(Fe)) into dual-crosslinked sodium alginate/polyvinyl alcohol hydrogel thin films for controlled 5-fluorouracil (5-FU) delivery. The resulting composite films exhibited high hydrophilicity and structural stability, supporting efficient drug accommodation and diffusion regulation. Comprehensive physicochemical characterization confirmed uniform incorporation of the porous framework within the polymeric network, yielding a mesoporous architecture with an average pore size of ∼2.75 nm and a specific surface area of ∼17.322 m²/g. The system achieved a high encapsulation efficiency (up to 92.18 %) and demonstrated sustained, non-burst drug release, reaching ∼78.4 % cumulative release over 120 h under physiological conditions, with kinetics consistent with diffusion-dominated non-Fickian transport. In vitro cytotoxicity studies using U-87 glioblastoma cells revealed enhanced anticancer activity with moderated toxicity relative to burst-release free 5-FU, indicating effective therapeutic performance with improved biocompatibility. These findings establish the MOF–hydrogel hybrid thin-film system as a promising localized delivery platform for glioblastoma treatment.</div></div>","PeriodicalId":15600,"journal":{"name":"Journal of Drug Delivery Science and Technology","volume":"118 ","pages":"Article 108049"},"PeriodicalIF":4.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146102468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Smart healthcare textiles: A review on the integration of nanomaterials for biomedical functionality","authors":"S. Muthulingam ,&nbsp;K. Raja ,&nbsp;K.P. Greeshma ,&nbsp;Raj Swetha ,&nbsp;S. Kalaiarasan ,&nbsp;S. Thiruppathi","doi":"10.1016/j.jddst.2026.108091","DOIUrl":"10.1016/j.jddst.2026.108091","url":null,"abstract":"<div><div>With its multifunctionality, adaptability, and improved patient outcomes, nanomaterial-integrated textiles are quickly becoming a game-changing class of materials in contemporary healthcare. Researchers have created smart textiles with properties ranging from wound healing and antimicrobial resistance to real-time physiological monitoring and controlled drug delivery by integrating functional nanomaterials like graphene, titanium dioxide, zinc oxide (ZnO), carbon nanotubes (CNTs), and silver nanoparticles into textile substrates. These cutting-edge fabrics have a lot of potential uses in wearable medicine, chronic illness management, remote diagnostics, and hospital settings. This review examines the various healthcare uses of textiles enabled by nanomaterials, such as antimicrobial fabrics, dressings that react to stimuli, wearable diagnostic devices, and clothing that protects against allergens and ultraviolet (UV) rays. Durability, scalability, safety, and regulatory control issues are critically examined, along with new worries about the effects on the environment and the morality of ongoing monitoring. Future directions including the creation of biodegradable nanocomposites, the design of hybrid multifunctional textile systems, and the fusion of artificial intelligence (AI) and the Internet of Things (IoT) are also highlighted in the paper. These developments open the door to a new age of intelligent, sustainable, and customized healthcare solutions powered by cutting-edge materials science.</div></div>","PeriodicalId":15600,"journal":{"name":"Journal of Drug Delivery Science and Technology","volume":"118 ","pages":"Article 108091"},"PeriodicalIF":4.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146172260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}