Journal of Drug Delivery Science and Technology最新文献

{"title":"Bovine serum albumin (BSA)-Loaded polyvinyl alcohol (PVA) / chitosan (CH) / hydroxyapatite (HA) electrospun nanofibers for bone tissue regeneration","authors":"Mehmet Bozdag ,&nbsp;Ferhat Urek ,&nbsp;Sumeyye Cesur ,&nbsp;Ali Sahin ,&nbsp;Oguzhan Gunduz","doi":"10.1016/j.jddst.2025.106712","DOIUrl":"10.1016/j.jddst.2025.106712","url":null,"abstract":"<div><div>The natural bone structure consists of three different nanocomposite layers; a porous polymer ceramic part, a lamellar, and a fiber-matrix composition gives the bone its unique physical and biological properties. During bone tissue regeneration bioactivity, and osteoinductivity are especially important with other parameters such as porosity, degradation rate, and cell adhesion. In this study, hydroxyapatite (HA) and bovine serum albumin (BSA) protein-loaded, polyvinyl alcohol (PVA) and chitosan (CH) nanofibers were fabricated via the electrospinning method. The mean diameters of PVA/CH/HA/BSA-5, PVA/CH/HA/BSA-10, and PVA/CH/HA/BSA-15 nanofibers were measured as 325.39 ± 77.512 nm, 332.45 ± 82.251 nm, 447.03 ± 101.382 nm respectively, required porosity and properties for bone tissue engineering were considered achieved. BSA release profiles of BSA-5, BSA-10, and BSA-15 nanofibers were similar in terms of burst release which continued until the 12th hour, 58 %, 78 %, and 73 % of the BSA were released, respectively. After 72 h 100 % of BSA were released from all nanofibers. Cell viability tests showed that PVA/CH/HA/BSA nanofibers exceeded the control group in terms of cell viability by 119.9 %. In future bone injury treatment, PVA/CH/HA/BSA nanofibers can assist the healing process of cracks and fractures, and decrease the recovery time of bone as an alternative bone healing nanofiber.</div></div>","PeriodicalId":15600,"journal":{"name":"Journal of Drug Delivery Science and Technology","volume":"106 ","pages":"Article 106712"},"PeriodicalIF":4.5,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143453079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pectin based stimuli responsive nanovesicles: A promising strategy for sustained release, and augmenting bioavailability of gemcitabine","authors":"Rashna Mirza ,&nbsp;Mohsin Fawad ,&nbsp;Amjad Ali Shah ,&nbsp;Kifayat Ullah Shah ,&nbsp;Atif Ullah Khan ,&nbsp;Naveed Ahmed ,&nbsp;Muhammad Amer","doi":"10.1016/j.jddst.2025.106715","DOIUrl":"10.1016/j.jddst.2025.106715","url":null,"abstract":"<div><div>This study aimed to develop pectin based, stimuli-responsive nanovesicles for gemcitabine delivery to address issues such as short half-life, poor bioavailability, and systemic side effects by providing targeted and sustained cancer treatment. Gemcitabine loaded pectin nanovesicles (Gem-Pec@NVs) were formulated using an emulsification crosslinking technique. Optimizing concentrations of pectin, Labrasol®, and calcium chloride resulted in nanovesicles with a vesicle size of 96.79 ± 0.12 nm, a PDI of 0.357 ± 0.04, and an entrapment efficiency of 83.2 ± 0.2 %. Statistical ANOVA and response surface plots were used to analyze the effects of formulation variables on vesicle size, PDI, and entrapment efficiency. Physicochemical characterization confirmed drug compatibility with other ingredients and successful loading into the nanovesicles. Morphological analysis revealed non-spherical nanovesicles. The optimized formulation was incorporated into a thermosensitive <em>in situ</em> gel for rectal delivery. <em>In vitro</em> release studies showed sustained release (79.1 ± 2.01 %) within 72 h with enzyme pectinase-triggered release compared to gemcitabine solution (98.66 ± 2.26 %). Cell cytotoxicity studies showed significant inhibition of colon cancer cells by Gem-Pec@NVs compared to Gemcitabine solution. <em>Ex vivo</em> studies demonstrated high permeation and mucoadhesion of the Gem-Pec@NVs-loaded <em>in situ</em> gel (834 ± 5.7 μg/cm² and 15,821.4 ± 4.9 dyne/cm²) compared to gemcitabine solution (62 ± 1.7 μg/cm²). Similarly, <em>in vivo</em> studies indicated high retention of nanovesicles in the colon, improved bioavailability, and confirmed the targeting ability of the nanovesicle-based <em>in situ</em> gel. Rectal irritation studies confirmed the non-irritant nature of the formulation, ensuring compatibility. This nanovesicle-based rectal delivery strategy offers a promising, non-invasive targeting approach for colorectal cancer.</div></div>","PeriodicalId":15600,"journal":{"name":"Journal of Drug Delivery Science and Technology","volume":"106 ","pages":"Article 106715"},"PeriodicalIF":4.5,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143464713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Potential and limitations of patient-specific inkjet printing on orodispersible films: A critical and practical look at innovation barriers for pharmaceutical applications","authors":"Friederike Brokmann,&nbsp;Ida Menzdorf,&nbsp;Anna Daab,&nbsp;Christoph Rosenbaum","doi":"10.1016/j.jddst.2025.106707","DOIUrl":"10.1016/j.jddst.2025.106707","url":null,"abstract":"<div><div>Innovative technologies are driving digitalization and major changes in the healthcare sector. 2D inkjet printing of orodispersible films (ODFs) for buccal and sublingual applications has often been described as an easy-to-implement and promising method for patient-specific drug preparation in the pharmacy. However, this study shows that the current state of inkjet printing technology has significant limitations that limit the use of commercial inkjet printers for pharmaceutical products is only possible to a limited extent. Experiments were conducted using fluorescein sodium as a highly visible and soluble drug substance to develop a basic ink formulation, comparative trials of processing caffeine in film- and capsule-based dosage forms, and processing mometasone as a poorly soluble drug substance to demonstrate the technological limitations were performed. Despite the ability to print intricate structures at high resolution on ODFs, the drug loading control remained a challenge, raising concerns about potential risks to patient safety. This demonstrates that inkjet printing is still not a ready-to-use solution to produce drug-loaded ODFs, and that further research is needed around dosing and printhead technology.</div></div>","PeriodicalId":15600,"journal":{"name":"Journal of Drug Delivery Science and Technology","volume":"106 ","pages":"Article 106707"},"PeriodicalIF":4.5,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143421486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Physical mixing of water-soluble polymers with amorphous solid dispersions based on L-HPC: Supporting supersaturation and improving the kinetic solubility profile","authors":"Alane Rafaela de Carvalho Amaral,&nbsp;Lucas José de Alencar Danda,&nbsp;Heloísa Casé Rigonatto,&nbsp;Azael Francisco Silva-Neto,&nbsp;José Lamartine Soares-Sobrinho,&nbsp;Monica Felts de La Roca Soares","doi":"10.1016/j.jddst.2025.106708","DOIUrl":"10.1016/j.jddst.2025.106708","url":null,"abstract":"<div><div>Amorphous solid dispersions (ASDs) are a proven strategy for enhancing the solubility and bioavailability of poorly water-soluble drugs. This study investigates the potential of hybrid systems, where ASDs composed of L-HPC were physically mixed with water-soluble polymers, including PVP K30, PVP K90, HPC, and HPMC. The objective was to evaluate how these combinations influence the kinetic-solubility profiles, precipitation inhibition, and dissolution behavior of indomethacin, a model BCS Class II drug. Additionally, direct comparisons were made with ASDs prepared solely with the respective water-soluble polymers to determine the advantages of the mixtures. Dissolution tests under non-sink conditions were conducted in 250 mL aqueous hydrochloric acid (pH 1.2) using a 20 mg drug-equivalent dose. Results demonstrated that adding water-soluble polymers significantly improved dissolution and supersaturation. Mixtures with PVPK30 exhibited rapid dissolution kinetics and prolonged supersaturation, with an AUC of 1846 ± 74 μg/mL/min, markedly higher than the 1161 ± 118 μg/mL/min for ASDs based solely on L-HPC. PVP K90 enhanced supersaturation duration but showed slower dissolution (AUC 1685 ± 65 μg/mL/min), whereas mixtures with HPMC provided sustained supersaturation (AUC 1221 ± 325 μg/mL/min) but delayed initial release due to gel formation. Direct ASDs based on PVP K90 outperformed their hybrid counterparts, while HPMC-based ASDs exhibited the slowest release profiles. These findings underscore the complementary benefits of combining L-HPC with water-soluble polymers, balancing immediate drug release with enhanced precipitation inhibition and tailored dissolution profiles. By optimizing polymer type and ratio, hybrid systems offer a promising strategy to improve bioavailability for challenging drug formulations.</div></div>","PeriodicalId":15600,"journal":{"name":"Journal of Drug Delivery Science and Technology","volume":"106 ","pages":"Article 106708"},"PeriodicalIF":4.5,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143445662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Visible light-activated mesoporous black titania nanorods for enhanced chemo-photodynamic cancer therapy","authors":"Estefanía Vélez-Peña ,&nbsp;Verónica A. Jiménez ,&nbsp;Joaquín Manzo-Merino ,&nbsp;Victoria Melin ,&nbsp;David Contreras ,&nbsp;Joel B. Alderete ,&nbsp;Cristian H. Campos","doi":"10.1016/j.jddst.2025.106713","DOIUrl":"10.1016/j.jddst.2025.106713","url":null,"abstract":"<div><div>Developing photoactive nanomaterials with drug-encapsulating properties is a relevant task for dual therapy applications aimed at overcoming the current limitations of conventional cancer treatments. In this work, we report the synthesis and evaluation of mesoporous black titania nanorods as novel visible-light responsive platforms for dual chemo-phototherapy. Nanorods were obtained by hydrothermal synthesis and photo-sensitized by titanium reduction via thermal decomposition of sodium borohydride at 400 °C under an argon atmosphere. The materials were characterized by X-ray diffraction, transmission electron microscopy, N₂ adsorption-desorption isotherms, X-ray photoelectron spectroscopy, electron paramagnetic resonance, and UV–vis diffuse reflectance spectroscopy. ROS generation experiments confirmed that aqueous dispersions of black titania nanorods produce hydroxyl radicals (HO^•) under visible light LED irradiation (150 W m⁻², 15 min). The materials exhibited moderate phototoxic activity against HeLa cells under visible light LED irradiation (150 W m⁻², 15 min) with cell viabilities ∼70 % at dispersion concentrations of 300 μg mL⁻¹, while no cytotoxic effects were observed in dark incubation conditions. Black titania nanorods efficiently encapsulated doxorubicin and released the drug in quantities suitable to exert chemotoxic effects against HeLa cells in the dark, with cell viabilities of ∼60 % at 500 μg mL⁻¹ dispersion concentrations and 24 h of incubation. Doxorubicin-loaded nanorods were evaluated in dual chemo-phototherapy experiments consisting of 12 h of dark incubation, 15 min of visible light LED irradiation, and 12 h of post-irradiation dark incubation. Our experiments showed a marked potentiation of antiproliferative effects compared with individual chemo or phototoxicity experiments, with cell viabilities ∼30 % at dispersion concentrations of 400 μg mL⁻¹. Our findings highlight the potential of black titania nanorods as intrinsically photoactive materials with drug-encapsulating properties for dual chemo-phototherapy applications.</div></div>","PeriodicalId":15600,"journal":{"name":"Journal of Drug Delivery Science and Technology","volume":"106 ","pages":"Article 106713"},"PeriodicalIF":4.5,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143421485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel cationic bolaamphiphiles for in vitro gene delivery and antibacterial properties","authors":"Pabitra Mondal ,&nbsp;Sadhana Roy ,&nbsp;Joykrishna Dey ,&nbsp;Somdeb Bose Dasgupta","doi":"10.1016/j.jddst.2025.106706","DOIUrl":"10.1016/j.jddst.2025.106706","url":null,"abstract":"<div><div>Bolaamphiphiles are known to exhibit interesting self-assembly behavior in water. Despite distinctive self-assembly properties and potential applications in fields such as gene therapy, drug delivery, and materials science, the research on cationic bolaamphiphiles remains nascent and under progress. The current study focuses on developing novel, biocompatible, and more effective cationic bolaforms for gene transfection. Accordingly, two cationic bolaforms that contain hydrolyzable amide and ester linkers, respectively, were designed and synthesized to investigate their gene transfection efficiency and antibacterial activity. The aqueous bolaform solutions were characterized by the use of a number of physical methods. The gene transfection efficiency of these bolaforms was compared with that of a standard transfection agent. The results of the in vitro cytotoxicity assay confirmed the safe use of these bolaforms. For the first time, we report here the binding interaction of cationic bolaform molecules with bovine serum albumin (BSA) protein. Although the weaker protein binding ability of these bolaforms reflected their low toxicity, these two bolaforms were shown to exhibit antibacterial activities against Gram-positive S. aureus, and Gram-negative E.coli pathogens.</div></div>","PeriodicalId":15600,"journal":{"name":"Journal of Drug Delivery Science and Technology","volume":"106 ","pages":"Article 106706"},"PeriodicalIF":4.5,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143436829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhanced efficacy and bioavailability of amikacin-loaded niosomal nanovesicles based on Low-HLB amphiphiles: In vitro/ex vivo/in vivo studies","authors":"Mohamed F. Zaky ,&nbsp;Mohamed H. Desoqi ,&nbsp;Tamer H. Hassan ,&nbsp;Shadeed Gad ,&nbsp;Mamdouh M. Ghorab ,&nbsp;Mohammed Amran ,&nbsp;Hossam S. El-Sawy","doi":"10.1016/j.jddst.2025.106709","DOIUrl":"10.1016/j.jddst.2025.106709","url":null,"abstract":"<div><div>A concept has been anticipated in this study that the loading of BCS (Biopharmaceutics Classification System) class-III medications within hydrophobic amphiphilic-based nanovesicles would potentially increase the permeability and internalization of these drugs into cells at their sites of action. Consequently, low-HLB (Hydrophilic-Lipophilic Balance) amphiphilic-based niosomal nanovesicles has been designed for enhancing <em>ex vivo</em> efficacy and <em>in vivo</em> bioavailability of amikacin sulphate (AMK), a BCS Class III drug-model. The influence of varying levels of Span 40/Span 60 as low-HLB amphiphiles was studied using a Quality by Design approach. The optimized nanovesicle has been predicted which showed 125.52 nm mean vesicle size and −23.1 mV zeta potential, along with 84.28 %, 13.89 % and 74.5 % of entrapment efficiency, initial and cumulative AMK release from niosomal nanovesicles, respectively. The <em>in vitro</em> release study of AMK from the optimized amphiphilic-based nanovesicles exhibited a controlled, biphasic 2nd order release pattern. <em>Ex vivo</em> studies revealed significant larger inhibition zones for the optimized AMK-loaded nanovesicles over the pure AMK against <em>Klebsiella pneumoniae</em>, <em>Escherichia coli</em>, and <em>Staphylococcus aureus</em>. Besides, the <em>in vivo</em> pharmacokinetics revealed a 1.75- and 2-fold increases in peak plasma concentration (C_max; 237.13 μg/mL) and the absorption profile (AUC_0–∞; 1018.01 μg/mL⨯h), respectively, compared to pure AMK, along with a significant decrease in clearance rate. These outcomes confirmed the potentiality of enhancing bioavailability and antibacterial activity of BCS Class III antibiotics with the implemented strategy, offering a promising approach for improved drug delivery with reduced required dose and minimized side effects.</div></div>","PeriodicalId":15600,"journal":{"name":"Journal of Drug Delivery Science and Technology","volume":"106 ","pages":"Article 106709"},"PeriodicalIF":4.5,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143430164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A complete sojourn on nanotechnological advancements and nanocarriers applications in arthritis management","authors":"Aman Kumar ,&nbsp;Rashmi Maurya ,&nbsp;Preeti Patel ,&nbsp;Manish Kumar ,&nbsp;Ravi Raj Pal ,&nbsp;Balak Das Kurmi","doi":"10.1016/j.jddst.2025.106705","DOIUrl":"10.1016/j.jddst.2025.106705","url":null,"abstract":"<div><div>Rheumatoid arthritis is a chronic autoimmune disease characterized by synovial hyperplasia, cartilage destruction, and pannus formation, ultimately leading to severe disability. Despite advancements in rheumatoid arthritis management, current treatments often lack specificity, cause systemic side effects, and fail to halt disease progression effectively. There is an urgent need for innovative, targeted therapeutic strategies that improve treatment effectiveness while minimizing side effects. The complexity of drug delivery to inflamed joints remains a critical challenge, necessitating precise, site-specific therapeutic approaches. Recent breakthroughs in nanotechnology offer highly efficient drug delivery systems, enabling enhanced targeting of inflamed synovial tissue through engineered nanocarriers. These include liposomes, nanoparticles, and carbon nanotubes, which can respond to the unique microenvironment of inflamed joints. Key molecular targets such as VEGF, CD44, and pro-inflammatory cytokines also present new opportunities for precise intervention in rheumatoid arthritis pathogenesis. Furthermore, the integration of herbal-based nanotherapeutics introduces a natural and potentially safer alternative to conventional treatments. The literature included in this review was selected from reputable scientific databases, including PubMed, Google Scholar, and Science Direct, focusing on recent advancements in nanotechnology-based therapies for rheumatoid arthritis. This review highlights the growing urgency to develop advanced, nanotechnology-driven therapeutic solutions for rheumatoid arthritis, emphasizing their role in early disease intervention, symptom alleviation, and disease-modifying activities. By bridging the gap between emerging nanomedicine and traditional pharmacotherapy, this study underscores the critical need for targeted, effective, and minimally invasive strategies to transform rheumatoid arthritis treatment.</div></div>","PeriodicalId":15600,"journal":{"name":"Journal of Drug Delivery Science and Technology","volume":"106 ","pages":"Article 106705"},"PeriodicalIF":4.5,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143445664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advancements in protein-based bionanocomposites for targeted and controlled drug delivery systems: A comprehensive review","authors":"Dahlang Tahir ,&nbsp;Syarifuddin Syarifuddin ,&nbsp;Ervina Efzan Mhd Noor ,&nbsp;Heryanto Heryanto ,&nbsp;Mohd Ambri Mohamed","doi":"10.1016/j.jddst.2025.106698","DOIUrl":"10.1016/j.jddst.2025.106698","url":null,"abstract":"<div><div>Protein-based bionanocomposites have emerged as transformative platforms in the rapidly advancing field of nanobiotechnology, offering unparalleled potential for targeted and controlled drug delivery systems. This comprehensive review highlights the synthesis, functionalization, and application of protein-based bionanocomposites, emphasizing their biocompatibility, biodegradability, and precision delivery capabilities. Key fabrication techniques such as nanoparticle encapsulation, surface modification, and polymer conjugation are critically analyzed for their role in optimizing drug release profiles and enhancing therapeutic efficacy. The review presents evidence of these systems overcoming challenges associated with conventional drug delivery methods, including nonspecific distribution, low bioavailability, and systemic toxicity. Clinical applications demonstrate remarkable outcomes, with protein-polymer conjugates achieving up to 96 % delivery efficiency and protein-nanoparticle composites exhibiting site-specific drug release in oncological and chronic disease therapies. Additionally, the biocompatibility and regulatory considerations of these systems are addressed to ensure their translational potential. The paper concludes by identifying emerging trends, such as stimuli-responsive hydrogels and advanced protein micelle systems, as promising avenues for addressing unmet clinical needs. This review underscores the transformative role of protein-based bionanocomposites in advancing precision medicine, paving the way for safer, more efficient, and patient-centered therapeutic strategies.</div></div>","PeriodicalId":15600,"journal":{"name":"Journal of Drug Delivery Science and Technology","volume":"106 ","pages":"Article 106698"},"PeriodicalIF":4.5,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143421488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating the dissolution behaviour of BCS class II antiretroviral drug loaded in lipid-nanocarriers: Evaluation of suitability of USP type IV flow through apparatus","authors":"Vanaja Kenchappa ,&nbsp;Surya Prakasarao Kovvasu ,&nbsp;Guru V Betageri","doi":"10.1016/j.jddst.2025.106666","DOIUrl":"10.1016/j.jddst.2025.106666","url":null,"abstract":"<div><div>Lipid-based nanocarriers (proliposomes) administered as sprinkle formulations could be an innovative research strategy for site-specific delivery of antiretroviral drugs (having poorly solubility and reduced bioavailability) on oral administration in special populations including paediatrics. Objective of the study was to formulate efavirenz (EFA) proliposomes to examine its dispersibility upon hydration and measure the rate of drug release using flow through USP type IV in comparison to conventionally used USP type II apparatus. On hydration, all proliposomal formulations formed negatively charged multilamellar vesicles of size around 500 nm and PDI &gt;0.3. Influence of lipid on dissolution of EFA proliposomes was prominent at 8 mL/min with USP type IV with similarity factor (<em>f2</em>)&lt;50; whereas with type II, <em>f2</em> was &gt;50 when discriminatory media was used. About 80 % EFA released within 1 h in compendial media, whereas exhibited 2–7.5 fold increase in varying pH media. Apparent permeability of EFA was increased (2.42 fold) across Caco-2 cells using proliposomes. Results demonstrated the superior discriminatory power of the USP IV, hence could be employed to evaluate dispersion ability and dissolution performance of poorly soluble drugs encapsulated in proliposomes.</div></div>","PeriodicalId":15600,"journal":{"name":"Journal of Drug Delivery Science and Technology","volume":"106 ","pages":"Article 106666"},"PeriodicalIF":4.5,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143445735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}