Journal of Drug Delivery Science and Technology最新文献_第4页

Controlled Release and Enhanced Bioavailability of Spray-Dried Microparticles Loaded with Liposoluble Vitamins and Natural Flavonoids Quercetin and Fisetin 载脂溶性维生素和天然类黄酮、槲皮素和非瑟酮喷雾干燥微颗粒的控释和增强生物利用度

IF 4.9 3区医学

Journal of Drug Delivery Science and Technology Pub Date : 2026-03-31 DOI: 10.1016/j.jddst.2026.108287

Maria Grazia Zizzo , Francesca Terracina , Carla Buzzanca , Sergio Scirè , Rosa Maria Dina , Noemi Aloi , Francesco Montalbano , Riccardo Messina , Gaetano Caldara , Mariano Licciardi

{"title":"Controlled Release and Enhanced Bioavailability of Spray-Dried Microparticles Loaded with Liposoluble Vitamins and Natural Flavonoids Quercetin and Fisetin","authors":"Maria Grazia Zizzo , Francesca Terracina , Carla Buzzanca , Sergio Scirè , Rosa Maria Dina , Noemi Aloi , Francesco Montalbano , Riccardo Messina , Gaetano Caldara , Mariano Licciardi","doi":"10.1016/j.jddst.2026.108287","DOIUrl":"10.1016/j.jddst.2026.108287","url":null,"abstract":"<div><div>Lipophilic bioactive compounds often exhibit poor aqueous solubility, chemical instability and low intestinal absorption, limiting their effectiveness in nutraceutical and pharmaceutical formulations. This study aimed to develop gastro-resistant spray-dried microparticles (MPs) capable of encapsulating and modulating the release of selected liposoluble molecules (fisetin, quercetin, β-carotene, vitamin A acetate and vitamin E). Five formulations (MILC-Fis, MILC-Q, MILC-β-car, MILC-Vit.A and MILC-Vit.E) were prepared within the innovative MILC® matrix (Micro Intelligent Lite Carrier), composed of milk and whey proteins (WPs), to obtain microparticles prepared exclusively with food-based materials. Scanning electron microscopy (SEM) analysis confirmed the formation of predominantly spherical particles with a mean diameter of approximately 15 ± 5 μm. MPs showed high encapsulation efficiencies, up to 79.6% for MILC-Q and 75.7% for MILC-Fis, exhibited pH-dependent release profiles with minimal release under gastric conditions (pH 1–2) and enhanced release at intestinal pH (6.8). <em>In vitro</em> studies demonstrated a significant increase in bioaccessibility, while <em>in vivo</em> pharmacokinetic evaluation revealed an improvement in bioavailability, with MILC-Q and MILC-Fis increasing the AUC by 8.2-fold and 2.47-fold, respectively, compared with the non-encapsulated compounds. These results highlight the potential of the MILC® protein matrix to protect lipophilic bioactives during gastric transit and enhance their intestinal availability and systemic exposure, supporting its applicability as a food-grade delivery platform for poorly soluble nutraceuticals and functional food formulations.</div></div>","PeriodicalId":15600,"journal":{"name":"Journal of Drug Delivery Science and Technology","volume":"121 ","pages":"Article 108287"},"PeriodicalIF":4.9,"publicationDate":"2026-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147584864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Double-layer Coating Containing Doxorubicin on Additively Manufactured Ti6Al4V Scaffolds for localized Bone Cancer Therapy 增材制造Ti6Al4V支架的含阿霉素双层涂层局部骨癌治疗

IF 4.9 3区医学

Journal of Drug Delivery Science and Technology Pub Date : 2026-03-24 DOI: 10.1016/j.jddst.2026.108245

Nasrin Karimi , Masoud Atapour , Aboozar Taherizadeh , Fatemeh Davar , Abdollah Saboori , Luca Iuliano

{"title":"Double-layer Coating Containing Doxorubicin on Additively Manufactured Ti6Al4V Scaffolds for localized Bone Cancer Therapy","authors":"Nasrin Karimi , Masoud Atapour , Aboozar Taherizadeh , Fatemeh Davar , Abdollah Saboori , Luca Iuliano","doi":"10.1016/j.jddst.2026.108245","DOIUrl":"10.1016/j.jddst.2026.108245","url":null,"abstract":"<div><div>Drug-loaded implants could play an important role in targeted bone cancer therapy when malignant bone tumors are removed. In this research, a topcoat containing doxorubicin (Dox) dispersed in a chitosan polymer matrix was applied to a calcium phosphate coating containing zinc oxide nanoparticles deposited by plasma electrolytic oxidation (PEO) on additively manufactured Ti6Al4V scaffolds and then evaluated. The polymer coating, as a thin layer containing the drug, was placed on the surface of the undercoat in samples with different porosities, leading to closure of pores and cracks, especially in surface depressions. The coatings improved the hydrophilic behavior compared to the underlying coating. The total drug loaded on the sample with smaller porosity and double-layer coating (SP-PEO-Dox) was higher than the sample with larger porosity (LP-PEO-Dox), approximately 0.13 mg. Drug release after 6 days for SP-PEO-Dox was about 67%, increasing with decreasing pH and larger pore size. Cell viability decreased from 94 (% control) in the PEO-only sample (SP-PEO) to 26 (% control) in SP-PEO-Dox, indicating doxorubicin’s effectiveness in inducing senescence and death of MG-63 cancer cells. Thus, SP-PEO-Dox is an optimal sample for orthopedic applications after bone tumor removal.</div></div>","PeriodicalId":15600,"journal":{"name":"Journal of Drug Delivery Science and Technology","volume":"121 ","pages":"Article 108245"},"PeriodicalIF":4.9,"publicationDate":"2026-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147584863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development of alpha-mangostin extract and citronella oil-loaded lipid-based nanocarriers for use as an antimicrobial agent in the treatment of periodontitis α -山竹苷提取物和香茅油负载脂基纳米载体的开发，用于治疗牙周炎的抗菌药物

IF 4.9 3区医学

Journal of Drug Delivery Science and Technology Pub Date : 2026-03-01 Epub Date: 2026-01-24 DOI: 10.1016/j.jddst.2026.108056

Wipada Samprasit , Ruchadaporn Kaomongkolgit , Benchawan Chamsai , Praneet Opanasopit , Ichaya Yiamwattana , Weeraya Tantanapornkul , Kusuma Jamdee , Suttimas Yuakyong

{"title":"Development of alpha-mangostin extract and citronella oil-loaded lipid-based nanocarriers for use as an antimicrobial agent in the treatment of periodontitis","authors":"Wipada Samprasit , Ruchadaporn Kaomongkolgit , Benchawan Chamsai , Praneet Opanasopit , Ichaya Yiamwattana , Weeraya Tantanapornkul , Kusuma Jamdee , Suttimas Yuakyong","doi":"10.1016/j.jddst.2026.108056","DOIUrl":"10.1016/j.jddst.2026.108056","url":null,"abstract":"<div><div>Periodontitis is a chronic inflammatory disease driven by biofilm-associated bacteria. Due to the limitations of conventional antimicrobials, this study evaluated the synergistic antibacterial and antibiofilm activities of alpha-mangostin extract (M) and citronella oil (C) against periodontal pathogens and developed lipid-based nanocarriers for local delivery in periodontal therapy. M and C were formulated into lipid-based nanocarriers, including nanoemulsions (NEs) and nanoemulgels (NEGs) to enhance their physicochemical properties. The formulations were evaluated for particle size, viscosity, drug release, antibiofilm activity, and cytotoxicity on human gingival fibroblasts (HGFs). The combination of M and C demonstrated a synergistic effect against <em>Porphyromonas gingivalis</em> (FICI ≤0.5). NEs and NEGs were successfully prepared for M and C loading; however, NEGs exhibited superior physical properties, including enhanced stability, good syringeability, acceptable viscosity, and controlled drug release, with MC-loaded NEGs showing a mean particle size of 307.6 ± 17.0 nm. Crucially, MC-loaded NEGs showed potent antibiofilm activity, achieving greater than 90 % inhibition of periodontal pathogen biofilms, comparable to 0.12 % chlorhexidine. Furthermore, the formulation demonstrated excellent biocompatibility, with HGF cell viability remaining above 85 % at concentrations up to 1000 μg/mL. These results suggest that MC-loaded NEGs are a promising and safe antimicrobial agent for managing periodontal disease.</div></div>","PeriodicalId":15600,"journal":{"name":"Journal of Drug Delivery Science and Technology","volume":"117 ","pages":"Article 108056"},"PeriodicalIF":4.9,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146074417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Corrigendum to “Angiogenesis and collagen promoting nutraceutical-loaded nanovesicles for wound healing” [J. Drug Deliv. Sci. Technol. 56, Part A (2020) 101548] “血管生成和胶原蛋白促进伤口愈合的营养营养负载纳米囊泡”的更正[J]。药物Deliv。科学。技术，56 (A) (2020) 101548]

IF 4.9 3区医学

Journal of Drug Delivery Science and Technology Pub Date : 2026-03-01 Epub Date: 2026-01-23 DOI: 10.1016/j.jddst.2026.108037

Saed Aldalaen , Maha Nasr , Riham I. El-Gogary

引用次数: 0

Corrigendum to “Integrating controlled vibration with PVDF nanofiber dressings: Mechanistic Insights into electromechanical wound healing” [J. Drug Deliv. Sci. Technol. (116), 107964] “集成控制振动与PVDF纳米纤维敷料：机械洞察机电伤口愈合”的修正[J]。药物Deliv。科学。抛光工艺。(116), 107964)

IF 4.9 3区医学

Journal of Drug Delivery Science and Technology Pub Date : 2026-03-01 Epub Date: 2026-01-29 DOI: 10.1016/j.jddst.2026.108047

George Bebawy , Asmaa Hegazy , Ahmed H. Hassanin , Nader Shehata , Alyaa Ramadan , Hebatallah S. Barakat

引用次数: 0

Liposomes functionalized with cyclic RGD for targeted chemo-photothermal-combined thrombus therapy 环RGD功能化脂质体用于靶向化疗-光热联合血栓治疗

IF 4.9 3区医学

Journal of Drug Delivery Science and Technology Pub Date : 2026-03-01 Epub Date: 2026-01-30 DOI: 10.1016/j.jddst.2026.108068

Guolong Shi , Minglin Ji , Sedrati Manar , Jing Chen , Guohua Jiang

{"title":"Liposomes functionalized with cyclic RGD for targeted chemo-photothermal-combined thrombus therapy","authors":"Guolong Shi , Minglin Ji , Sedrati Manar , Jing Chen , Guohua Jiang","doi":"10.1016/j.jddst.2026.108068","DOIUrl":"10.1016/j.jddst.2026.108068","url":null,"abstract":"<div><div>Antithrombotic medications, including antiplatelet drugs, anticoagulants, and thrombolytics, remain fundamental to the clinical management of thrombosis, as they are widely used in the treatment of cardiovascular diseases and other conditions to prevent and treat thrombotic events. Thrombolytic agents, such as urokinase and streptokinase, are pivotal in the treatment of acute thrombotic diseases by activating the fibrinolytic system to dissolve blood clots. However, these agents face challenges due to their limited targeting specificity, short half-life, and varying efficiency, which can result in suboptimal therapeutic outcomes. In this study, we developed cyclic RGD (cRGD)-functionalized liposomes (IR/LK@cLip) to encapsulate IR-780 and lumbrokinase (LK). Leveraging the affinity of the RGD sequence for activated platelet membrane glycoprotein IIb/IIIa receptors, we aimed to improve the targeted chemo-photothermal combined therapy for thrombi. The cRGD can specifically target GPIIb-IIIa receptors, which are overexpressed on activated platelets, enabling the fabricated liposomes to actively recognize thrombi. When exposed to near-infrared (NIR) laser irradiation, IR-780, acting as a photosensitizer, can induce the disintegration of liposomes and promote the release of LK, which enhances drug penetration efficiency by increasing thrombus porosity. <em>In vivo</em> studies have confirmed that IR/LK@cLip exhibits effective accumulation at the site of thrombus formation. Moreover, the IR/LK@cLip has demonstrated the ability to rapidly restore blood circulation at thrombosed locations, suggesting its potential as a powerful antithrombotic treatment.</div></div>","PeriodicalId":15600,"journal":{"name":"Journal of Drug Delivery Science and Technology","volume":"117 ","pages":"Article 108068"},"PeriodicalIF":4.9,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147397307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent approaches of proliposome-based dry powder inhalation for pulmonary delivery 以丙脂质体为基础的干粉吸入用于肺输送的新方法

IF 4.9 3区医学

Journal of Drug Delivery Science and Technology Pub Date : 2026-03-01 Epub Date: 2026-01-28 DOI: 10.1016/j.jddst.2026.108053

Ujwal A. Havelikar, Sakshi B. Magar , Abhishek K. Teharke , Nilesh B. Chaudhari

{"title":"Recent approaches of proliposome-based dry powder inhalation for pulmonary delivery","authors":"Ujwal A. Havelikar, Sakshi B. Magar , Abhishek K. Teharke , Nilesh B. Chaudhari","doi":"10.1016/j.jddst.2026.108053","DOIUrl":"10.1016/j.jddst.2026.108053","url":null,"abstract":"<div><div>Pulmonary drug delivery via dry powder inhalers (DPIs) has gained substantial interest owing to its non-invasive nature, rapid onset of action, and potential for local and systemic therapy. Limitations on aerodynamic size and the lung's lower tolerance compared with the oral route make it challenging to formulate dry powders for pulmonary delivery. Proliposomes (PL), as dry, free-flowing particulate precursors of liposomes, offer a promising platform to overcome these challenges. In addition to being easier to handle and more stable than traditional liposomal systems, these recent proliposome-based DPIs are also being investigated for their potential scalability in pharmaceutical manufacture. These developments in the DPI system based on PL show enhanced pulmonary targeting, sustained drug release, and advantageous aerodynamic characteristics. This review focuses on the formulation strategies, various techniques to develop the DPIs and summarizes the recent (2020–2025) progress in proliposome-based DPI systems. It also highlights COVID-era advancements in inhalable lipid carriers for vaccines and antiviral agents. Further clinical applications of PL-DPIs with disease-specific perspectives is discussed. Also, the article addresses the regulatory considerations, current challenges and the future perspectives of proliposomal-based DPI technology in the respiratory drug delivery.</div></div>","PeriodicalId":15600,"journal":{"name":"Journal of Drug Delivery Science and Technology","volume":"117 ","pages":"Article 108053"},"PeriodicalIF":4.9,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147397916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Topical delivery of Niaouli essential oil nanoemulsion via Chitosan:Polyvinyl alcohol patches: A promising antimicrobial strategy for potential biomedical applications 壳聚糖-聚乙烯醇贴剂局部递送牛油纳米乳：一种具有潜在生物医学应用前景的抗菌策略

IF 4.9 3区医学

Journal of Drug Delivery Science and Technology Pub Date : 2026-03-01 Epub Date: 2026-01-07 DOI: 10.1016/j.jddst.2026.107992

Didem Demir , Semih Latif İpek , Oskay Kahraman , Sibel Dağlı , Seda Ceylan

{"title":"Topical delivery of Niaouli essential oil nanoemulsion via Chitosan:Polyvinyl alcohol patches: A promising antimicrobial strategy for potential biomedical applications","authors":"Didem Demir , Semih Latif İpek , Oskay Kahraman , Sibel Dağlı , Seda Ceylan","doi":"10.1016/j.jddst.2026.107992","DOIUrl":"10.1016/j.jddst.2026.107992","url":null,"abstract":"<div><div>Niaouli essential oil (NEO), selected as a bioactive compound, is a volatile oil known for its antiviral, antifungal, antibacterial, and antioxidant activities. To overcome the limitations associated with direct use of NEO, nanoemulsion formulations were developed, aiming for stability, long-term release, and controlled use. In this study, NEO nanoemulsions (NEO-NEs) were prepared, incorporated into a polymeric matrix, and evaluated for their potential use as antimicrobial patches. Three different oil-in-water emulsion formulations were produced, and the droplet size analyses were performed. Thin polymeric films were produced as carrier matrices for the optimal NEO-NEs formulation. Polymer matrices based on chitosan (CS) and polyvinyl alcohol (PVA) were physicochemically characterized in the presence of different volumes of NEO-NEs (10, 20, and 30 μL). The sample containing 20 μL of NEO-NEs exhibited a homogeneous morphology and achieved a swelling ratio of approximately 300 times its initial weight without compromising structural stability. Both direct and indirect cytotoxicity tests demonstrated that the NEO-NEs additive had no adverse effect on the biocompatibility. GC–MS analysis identified the main components of NEO, revealing a rich terpenoid composition that exhibited time-dependent antioxidant activity. Release studies showed a controlled, stable, and sustained release profile over 48 h. Microbiological evaluations showed high antifungal activity, particularly against <em>Candida albicans</em>. Overall, the findings of this study highlight the significant potential of NEO-incorporated polymeric adhesive patches for the prevention of fungal infections.</div></div>","PeriodicalId":15600,"journal":{"name":"Journal of Drug Delivery Science and Technology","volume":"117 ","pages":"Article 107992"},"PeriodicalIF":4.9,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145980386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring the functional diversity of hypoxia-responsive polymers in drug delivery: A comparative analysis 探讨低氧反应聚合物在药物传递中的功能多样性：比较分析

IF 4.9 3区医学

Journal of Drug Delivery Science and Technology Pub Date : 2026-03-01 Epub Date: 2026-01-15 DOI: 10.1016/j.jddst.2026.108026

Hina Tahir , Abdullah K. Alanazi , Zaheer Ahmad

{"title":"Exploring the functional diversity of hypoxia-responsive polymers in drug delivery: A comparative analysis","authors":"Hina Tahir , Abdullah K. Alanazi , Zaheer Ahmad","doi":"10.1016/j.jddst.2026.108026","DOIUrl":"10.1016/j.jddst.2026.108026","url":null,"abstract":"<div><div>Cancer continues to be a main cause of worldwide morbidity and mortality, and standard treatments encounter restrictions such as multidrug resistance, tumor heterogeneity, and systemic toxicity. These limitations have navigated the evolution of stimuli-responsive polymer-based drug delivery systems (DDSs) that increase the ratio of drug accumulation at tumor sites while decreasing systemic toxicity. Hypoxia, a primary characteristic of most solid tumors, has been determined as a significant internal stimulus for drug release. Hypoxia-responsive polymers consume oxygen-sensitive moieties such as azobenzene derivatives and nitroimidazole conjugates, which go through bioreduction under hypoxic conditions to initiate drug release. This review delivers a comparative analysis of azobenzene and nitroimidazole-based hypoxia-responsive DDS, concentrating on their synthesis, physicochemical characteristics, modes of activation, and therapeutic efficacy. Azobenzene-based systems provide dual responsiveness to hypoxia and light, while nitroimidazole-based systems depend on enzymatic bioreduction for targeted activation in deep-rooted tumors. Both systems illustrate upgraded drug selectivity, reduced toxicity, and improved therapeutic results compared to conventional DDSs. Regardless of this progress, challenges remain in accomplishing synthesis success and clinical application. Future expectations highlight hybrid and multi-targeted responsive designs, in combination with precision medicine and nanotheranostic applications. Generally, hypoxia-responsive polymeric drug delivery systems provide a potential environment for detailed, controlled, and tumor-specific drug delivery in advanced cancer treatment.</div></div>","PeriodicalId":15600,"journal":{"name":"Journal of Drug Delivery Science and Technology","volume":"117 ","pages":"Article 108026"},"PeriodicalIF":4.9,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146035337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Catalase grafted electrospun urethane-crosslinked fibers for osteogenic differentiation 过氧化氢酶接枝电纺聚氨酯交联纤维用于成骨分化

IF 4.9 3区医学

Journal of Drug Delivery Science and Technology Pub Date : 2026-03-01 Epub Date: 2026-01-08 DOI: 10.1016/j.jddst.2026.107993

Seyyed Ahmad Seyyed Nasrollah, Reza Karimi-Soflou, Akbar Karkhaneh

{"title":"Catalase grafted electrospun urethane-crosslinked fibers for osteogenic differentiation","authors":"Seyyed Ahmad Seyyed Nasrollah, Reza Karimi-Soflou, Akbar Karkhaneh","doi":"10.1016/j.jddst.2026.107993","DOIUrl":"10.1016/j.jddst.2026.107993","url":null,"abstract":"<div><div>In bone tissue engineering (BTE), preparing a suitable environment for cell adhesion, proliferation, and osteogenic differentiation is a vital property for scaffold design. These scaffolds should be able to provide osteogenic agents and critical agents for cell viability, such as oxygen. This study presents novel magnesium peroxide (PMP)-loaded PLA/PGS nanofibers with urethan corsslinked that regulate pH and sustain the release of oxygen and magnesium ions to support the osteogenic differentiation of mesenchymal stem cells. The fabricated nanofibers not only maintain the environment's pH within the physiological range but also sustain the release of magnesium ions and oxygen for 15 days. The results of the alkaline phosphatase activity and Alizarin Red staining assays show the osteogenic differentiation potential of the PMP-containing PGS/PLA nanofibers over 21 days. Also, the PGS/PLA nanofibers can trigger mesenchymal stem cells to osteogenic differentiation, as evidenced by the levels of Alkaline phosphatase, Runt-related transcription factor 2, Osteocalcin, and Osteopontin expression over 21 days. These <em>in-vitro</em> results highlight the nanofibers' potential as an appropriate scaffold for BTE, demonstrating their capacity to support cell adhesion, proliferation, and differentiation.</div></div>","PeriodicalId":15600,"journal":{"name":"Journal of Drug Delivery Science and Technology","volume":"117 ","pages":"Article 107993"},"PeriodicalIF":4.9,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145980836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0