Journal of Drug Delivery Science and Technology最新文献

{"title":"Chitosan decorated nanostructurated lipid carriers for augmented oral bioavailability of velpatasvir; D-optimal optimization, in silico, in vitro, ex vivo and in vivo studies","authors":"Menna M. Abdellatif ,&nbsp;Joseph N. Shohdy ,&nbsp;Doaa Ahmed El-Setouhy ,&nbsp;Mohammed IA. Hamed ,&nbsp;Basant F. Rofaeil ,&nbsp;Marianne J. Naguib ,&nbsp;Mohamed A. El-Nabarawi","doi":"10.1016/j.jddst.2025.106703","DOIUrl":"10.1016/j.jddst.2025.106703","url":null,"abstract":"<div><div>Velpatasvir is an antiviral, poorly soluble drug used to treat Hepatitis C; however, it possesses low oral bioavailability and belongs to the BCS class IV. Therefore, incorporating velpatasvir into nanostructurated lipid carriers (NLCs) could enhance its oral bioavailability. The NLCs were fabricated employing hot melt emulsification. A surface response design (D-optimal) was used where the studied factors were the total lipid percent, the percentage of liquid lipid, the type of liquid lipid, and the type of surfactants. The particle size (PS), polydispersity index (PDI), zeta potential (ZP), and entrapment efficiency percent (EE %) of NLCs were assessed. The optimized formula was coated with chitosan and characterized in terms of morphology, <em>ex vivo</em> studies, thermal analysis, and thermodynamic stability. Finally, <em>in vivo</em> studies were conducted, including pharmacokinetics and toxicity studies. The optimized formula had a PS of 150.51 ± 2.9 nm, PDI of 0.2 ± 0.005, ZP of −32.4 ± 0.98 mV, and EE% of 49.02 ± 1.1 %. The chitosan-decorated NLC was spherical and revealed a higher apparent permeability coefficient than drug dispersion. The thermal analysis confirmed the solubilization of velpatasvir within the lipid matrix, while the <em>in silico</em> study assured the thermodynamic stability of the chitosan-decorated velpatasvir-loaded NLCs. The AUC_<em>0-t</em> and C_<em>max</em> of chitosan-decorated velpatasvir-loaded NLCs were 5-fold and 6.75-fold, respectively, compared to the drug dispersion, while the toxicity study revealed no difference between the groups treated with nanoformulation or drug dispersion. This study confirmed the potentiality of chitosan-decorated NLCs for augmenting the oral bioavailability of velpatasvir.</div></div>","PeriodicalId":15600,"journal":{"name":"Journal of Drug Delivery Science and Technology","volume":"106 ","pages":"Article 106703"},"PeriodicalIF":4.5,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143421484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular sieve as a kind of nano drug carrier: Application and exploration in modern medical technology——A review","authors":"Ke Wang ,&nbsp;Xiaomin Xia ,&nbsp;Zhimin Zhang ,&nbsp;Xue Li","doi":"10.1016/j.jddst.2025.106702","DOIUrl":"10.1016/j.jddst.2025.106702","url":null,"abstract":"<div><div>In recent years, the Nano Drug Delivery System (NDDS) has significantly captured the interest of scientists. Utilizing nanomaterials is recognized as an exceptionally promising method for drug delivery across various medical disciplines. Considerable research has led to groundbreaking advancements in this area. Among these developments, molecular sieves, also known as zeolites, have emerged as a notable class of aluminosilicate crystalline materials. Molecular sieves' porous nature allows for the encapsulation of antibacterial and anticancer drugs, facilitating targeted delivery. They can control drug release, reducing drug resistance in microbes and tumors. Besides drug delivery, they contribute to osteogenesis, useful in dental implant coatings. Their potential in hemostatic bandages also highlights their versatility and broad medical applicability. When writing this review, an exhaustive search was conducted on PubMed, Elsevier ScienceDirect, Wiley Online Library, and Web of Science. While taking into account the novelty of the selected articles, some valuable foundational articles were also reviewed. Before December 30, 2024, full-text articles related to molecular sieve drug delivery systems and other biomedical applications of molecular sieves were selected. In this article, we briefly described and discussed the research on different types of molecular sieves loaded with drugs that possessing different functions. At the same time, we also collected and discussed some research on different types of molecular sieves used in other biomedical fields, including antidiarrheal treatment and hemostasis, which emphasizes the wide-ranging impact of molecular sieves in healthcare and medical research.</div></div>","PeriodicalId":15600,"journal":{"name":"Journal of Drug Delivery Science and Technology","volume":"106 ","pages":"Article 106702"},"PeriodicalIF":4.5,"publicationDate":"2025-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143421490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The antibacterial activity and osteoblastic viability of bioactive polymeric coatings on titanium surfaces for dental implants: A systematic review of in vitro studies","authors":"Juliana Dias Corpa Tardelli,&nbsp;Andréa Cândido dos Reis","doi":"10.1016/j.jddst.2025.106684","DOIUrl":"10.1016/j.jddst.2025.106684","url":null,"abstract":"<div><div>Polymeric coatings incorporated with tissue engineering materials have become attractive due to their ability to make the surface of titanium and its alloys antimicrobial and pro-osteogenic. Thus, this review aimed to answer \"Do the polymeric hybrid coatings applied on titanium and its alloys surfaces for dental implants present antibacterial activity and osteoblastic viability? This review followed The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). Of 278 articles found, 25 met the eligibility criteria. The data found were analyzed regarding the type of polymer, biopolymer or synthetic, and associated material, metallic nanoparticles, bioceramics, proteins, antibiotics, and others. For risk of bias, 11 had a low risk, 12 had a moderate risk, and 2 had a high risk. It was concluded that of the 25 <em>in vitro</em> evaluation studies, 23 presented polymeric coatings with antibacterial activity and osteoblastic viability. Thus, the promising results of this review reinforce the need for continuous research for the development of bioactive polymeric coatings that could be a solution in limited cases and motivate the development of preclinical studies that verify their real viability, amount of drug needed, best method for sterilization, durability, and regulation to increase the number of patents, commercialization, and safe clinical application.</div></div>","PeriodicalId":15600,"journal":{"name":"Journal of Drug Delivery Science and Technology","volume":"106 ","pages":"Article 106684"},"PeriodicalIF":4.5,"publicationDate":"2025-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143395771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"3,4-Dihydroxyhydrocinnamic acid conjugated methoxy-poly(ethylene glycol)-poly(lactic acid) polymeric micelles for Bortezomib delivery and efficacy enhancement in doxorubicin-resistant breast cancer","authors":"Shishira P. S,&nbsp;Milan Paul,&nbsp;Swati Biswas","doi":"10.1016/j.jddst.2025.106700","DOIUrl":"10.1016/j.jddst.2025.106700","url":null,"abstract":"<div><div>Breast cancer (BC) is one of the significant malignant cancers diagnosed in women and is the second cause of mortality in women worldwide. Bortezomib (BTZ) treatment via conventional therapy causes off-targeting and premature drug release. Conjugation of 3,4-dihydroxyhydrocinnamic acid (DC), a phenolic compound with methoxy-poly (ethylene glycol)-poly (D, L-lactide) [mPP] to form a self-assembled amphiphilic polymer, mPP-DC to load BTZ will enhance the drug loading efficiency and provides the synergetic anti-cancerous effect. ¹H NMR and FTIR confirmed the synthesis of the product. Several physicochemical characterization studies were performed, such as differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), dynamic light scattering (DLS), X-ray diffraction (XRD) techniques, critical micelles concentration (CMC) determination, encapsulation efficiency (EE), % drug loading (DL), cumulative drug release, and hemolysis studies for the BTZ-mPP and BTZ-mPP-DC micelles. <em>In vitro</em> cell studies were performed using MCF-7 sensitive (S) and MCF-7 resistant (R) cells. Cytotoxicity study showed a reduced IC₅₀ value of the BTZ-mPP-DC compared to free drug and BTZ-mPP. Other <em>in vitro</em> studies such as cellular uptake, mitochondrial membrane potential (MMP) assay, reactive oxygen species (ROS), cell cycle analysis, colony formation assay, anti-proliferation assay, and western blot analysis were performed in both the cells. <em>In vivo</em> pharmacokinetics study was done to analyze the bioavailability of the formulation in the body for a long time. The developed biodegradable, biocompatible nanoformulation showed excellent penetration and cytotoxicity to the cancer cells; hence, BTZ-mPP-DC proves its novel efficacy in cancer treatment, especially in breast cancer.</div></div>","PeriodicalId":15600,"journal":{"name":"Journal of Drug Delivery Science and Technology","volume":"106 ","pages":"Article 106700"},"PeriodicalIF":4.5,"publicationDate":"2025-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143386606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How to deliver an unselective drug selectively: Novel puromycin-loaded albumin nanoparticles for active targeting and their controllable effectiveness","authors":"Xenia Tran,&nbsp;Dennis Mulac,&nbsp;Klaus Langer","doi":"10.1016/j.jddst.2025.106701","DOIUrl":"10.1016/j.jddst.2025.106701","url":null,"abstract":"<div><div>Cell specific targeting of cancer cells has been a widely investigated field in pharmaceutical nanotechnology. In this study, the active targeting properties of PEGylated albumin-based nanoparticles with covalently attached trastuzumab was investigated with regard to selective toxicity on HER2/neu-positive cell lines. For this purpose, the non-selective cytotoxic compound puromycin was successfully incorporated into albumin-based nanoparticles through covalent binding via a cathepsin B cleavable linker to the albumin matrix. It could subsequently be shown that puromycin was only released in presence of cathepsin B.</div><div>Selective cytotoxicity was assessed by a series of WST-1 assays which revealed that the puromycin-loaded nanoparticles with active targeting surface modification did lead to selective cytotoxicity on HER2/neu-positive cell lines SK-Br-3 and BT-474, while simultaneously protecting HER2/neu-negative MCF-7 from the cytotoxic effects of puromycin. This cytotoxic effect on HER2/neu-positive cells could be hindered by prior saturation of HER2/neu receptor with free trastuzumab. Controls without puromycin-loading remained non-toxic on all tested cell lines. We believe that this approach of API incorporation into protein-based nanoparticles through the concept of enzymatically cleavable linkers can be applied to a wide range of drugs. Likewise, the concept of active targeting vehicles for unselective drugs can also be employed to multiple extracellular target structures. Combining both, this nanoparticle design offers a broad spectrum of possibilities for promising therapeutic targeting concepts.</div></div>","PeriodicalId":15600,"journal":{"name":"Journal of Drug Delivery Science and Technology","volume":"106 ","pages":"Article 106701"},"PeriodicalIF":4.5,"publicationDate":"2025-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143379274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Amphotericin B PLGA nanoparticles loaded dissolving microneedle patches in treating cutaneous fungal infections","authors":"Ke Peng ,&nbsp;Aiman Abu Ammar ,&nbsp;Achmad Himawan ,&nbsp;Xianbing Dai ,&nbsp;Ross Duncan ,&nbsp;Brendan F. Gilmore ,&nbsp;Ryan F. Donnelly ,&nbsp;Lalitkumar K. Vora","doi":"10.1016/j.jddst.2025.106697","DOIUrl":"10.1016/j.jddst.2025.106697","url":null,"abstract":"<div><div>Cutaneous fungal infections pose a significant health challenge, particularly in deeper skin layers where topical treatments are ineffective. Amphotericin B (AmB) is the gold standard for treating fungal infections, but its poor solubility limits its transdermal delivery. In this work, AmB was loaded into polylactic-co-glycolic acid nanoparticles (PLGA NP) <em>via</em> the solvent deposition method. The resulting NP had an average size of 311.54 ± 2.08 nm and a polydispersity index (PDI) of 0.22 ± 0.12. After reconstitution, the particle size decreased to 209.89 ± 1.10 nm, with a PDI of 0.10. The encapsulation efficiency was 98.59 ± 0.10%. These AmB-loaded PLGA NP were then incorporated into dissolving microneedles (MNs) using a sequential loading method. The MNs demonstrated adequate mechanical strength to deliver the NP into the deep dermal layers, with an insertion depth of 363.5 μm and a height reduction of only 3.56 ± 2.10% under compression. <em>In vitro</em> release studies revealed an initial burst release of 60% within 1 h, followed by a slower release over four days. <em>Ex vivo</em> skin deposition and permeation studies demonstrated remarkable deposition of the drug into the dermis skin layers. This delivery system offers significant potential for treating cutaneous fungal infections, combining the benefits of sustained drug release and targeted delivery to deep skin layers.</div></div>","PeriodicalId":15600,"journal":{"name":"Journal of Drug Delivery Science and Technology","volume":"106 ","pages":"Article 106697"},"PeriodicalIF":4.5,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143386605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Co-delivery of hydroxyapatite nanoparticles and methylprednisolone using sodium alginate/silk fibroin hydrogel for simultaneous bone mineralization and anti-inflammation actions","authors":"Nguyen Thi Phuong Thao ,&nbsp;Phuong T.M. Ha ,&nbsp;Hong Khanh Ngo ,&nbsp;Ngoc Yen Nguyen ,&nbsp;Huynh Vu Thanh Luong ,&nbsp;Tran Thi Bich Quyen ,&nbsp;Nguyen Trong Tuan ,&nbsp;Ngoc Huyen Nguyen ,&nbsp;Duy Toan Pham","doi":"10.1016/j.jddst.2025.106699","DOIUrl":"10.1016/j.jddst.2025.106699","url":null,"abstract":"<div><div>Bone disorders such as osteoarthritis, rheumatoid arthritis, and bone fractures require simultaneous bone mineralization and anti-inflammatory treatments. Individual therapies might need high doses, increasing the risks of adverse effects. Hence, this research developed a dual-functional sodium alginate/silk fibroin hydrogel (SA/SF) co-encapsulating hydroxyapatite nanoparticles (CaP) for bone mineralization and methylprednisolone (MP) for anti-inflammatory activity. The SA/SF hydrogel was formulated by the ionic crosslinking process with Ca²⁺, where CaP particles and MP were loaded by mechanical mixing. The product structures were confirmed by X-ray diffraction (XRD) and Fourier-transform infrared spectroscopy (FT-IR); the CaP size was determined by dynamic light scattering method; the MP release and bone mineralization was conducted in simulated bodily fluid, utilizing the UV–Vis spectroscopy and scanning electron microscopy, respectively. For the results, the dual-functional hydrogel was successfully prepared, with a MP drug loading efficiency of 97.1 %, a nano-sized CaP of 582 ± 33 nm, and appropriate chemical interactions. In the <em>in vitro</em> bone mineralization test, the SA/SF/CaP-MP hydrogel demonstrated the formation of hydroxyapatite crystals, which gradually increased (proven by crystallinity index, calculated from FT-IR data) as the mineralization time was extended from 0 to 7 days. Moreover, the release of MP from the hydrogel could be significantly controlled and prolonged for 7 days, reaching a maximum release efficiency of 76.12 %. Additionally, the SA/SF/CaP-MP hydrogel did not cause cell membrane irritation, proven by the HET-CAM results. These results collectively demonstrate that the SA/SF/CaP-MP hydrogel provides a promising dual-functional platform for bone regeneration and localized anti-inflammatory treatment.</div></div>","PeriodicalId":15600,"journal":{"name":"Journal of Drug Delivery Science and Technology","volume":"106 ","pages":"Article 106699"},"PeriodicalIF":4.5,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143395778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Harnessing electrospun nanofibers for comprehensive oral disease management: Current trends and future perspectives","authors":"Riya Gupta ,&nbsp;Giriraj Pandey ,&nbsp;Ajay Kumar ,&nbsp;Anupriya Kapoor ,&nbsp;Suraj Wagh ,&nbsp;Tejaswini Kolipaka ,&nbsp;Paras Famta ,&nbsp;Alabhya Mishra ,&nbsp;Saurabh Srivastava ,&nbsp;Shashi Kiran Misra","doi":"10.1016/j.jddst.2025.106681","DOIUrl":"10.1016/j.jddst.2025.106681","url":null,"abstract":"<div><div>Oral health is integral to overall well-being, influencing key physiological functions such as speech, chewing, and sensory perception. Despite being largely preventable, oral diseases remain prevalent, affecting over 3.5 billion people globally, with substantial economic implications. Conditions like oral cancer, oral ulcers, and infections significantly reduce the quality of life and present ongoing challenges in treatment. Recent advancements in nanostructured drug delivery systems (DDS) have garnered significant attention for treating and managing oral diseases, offering enhanced drug absorption via the oral mucosa, efficient drug targeting, reduced systemic toxicity, and improved patient compliance. Among these, nanofiber-based oral patches, films, mats, and scaffolds have emerged as promising platforms due to their sustained drug-release capabilities and the ability to deliver multiple therapeutic agents. Nanofiber systems offer targeted and controlled drug delivery with high surface area-to-volume ratios, porosity, and customizable composition, reducing systemic toxicity and addressing challenges like poor solubility or enzymatic degradation. This review explores the current trends in nanofiber-based systems for managing oral diseases, including oral cancer, ulcers, candidiasis, and tissue regeneration. It further discusses the commercialization landscape, regulatory challenges, and future perspectives, emphasizing the importance of interdisciplinary research and innovation in overcoming existing barriers. This comprehensive overview underscores the transformative potential of electrospun nanofibers in advancing oral healthcare, offering promising solutions for improving patient outcomes in managing oral diseases.</div></div>","PeriodicalId":15600,"journal":{"name":"Journal of Drug Delivery Science and Technology","volume":"106 ","pages":"Article 106681"},"PeriodicalIF":4.5,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143395773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EGF-induced P-gp expression in tumor vasculature contributes to therapeutic resistance to doxorubicin-PEG-liposomes in mice bearing doxorubicin-resistant B16-BL6 tumors","authors":"Masato Maruyama ,&nbsp;Tomoki Ueda ,&nbsp;Yusuke Ienaka ,&nbsp;Haruka Tojo ,&nbsp;Kenji Hyodo ,&nbsp;Ken-ichi Ogawara ,&nbsp;Kazutaka Higaki","doi":"10.1016/j.jddst.2025.106690","DOIUrl":"10.1016/j.jddst.2025.106690","url":null,"abstract":"<div><div>We previously indicated that doxorubicin (DOX)-loaded polyethylene glycol (PEG)-modified liposomes (DOX-PEG-liposomes) were therapeutically effective in mice bearing DOX-resistant colon-26 (C26/DOX) tumors, and the efficacy was comparable in mice bearing DOX-sensitive C26 tumors. However, in the current study, DOX-PEG-liposomes exerted no therapeutic activity in DOX-resistant B16-BL6 melanoma (B16/DOX)-bearing mice, although they significantly suppressed DOX-sensitive B16 tumor growth in mice. Although we previously reported that the anti-tumor effects in C26/DOX-bearing mice were derived from the cytotoxic effects of DOX on vascular endothelial cells (VECs) in tumors, the B16/DOX tumor vasculature was not substantially damaged after administration of DOX-PEG-liposomes. In B16/DOX tumors, P-gp expression was significantly induced in the VECs, but not in the C26/DOX tumors, indicating that the high expression of P-gp in the tumor vasculature would be responsible for the lack of therapeutic effect of DOX-PEG-liposomes in B16/DOX-bearing mice. Epidermal growth factor (EGF), a possible induction factor for P-gp expression, was highly expressed in B16/DOX cells and tumor tissues, and significantly induced P-gp expression in human umbilical vein endothelial cells (HUVEC). The EGF receptor (EGFR) was also highly expressed in B16/DOX tumor VECs, suggesting that the activation of EGF/EGFR signaling may induce P-gp expression in VECs in B16/DOX tumors.</div></div>","PeriodicalId":15600,"journal":{"name":"Journal of Drug Delivery Science and Technology","volume":"106 ","pages":"Article 106690"},"PeriodicalIF":4.5,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143453078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A mechanistic understanding to photophysical phenomenon in development of near-infrared (NIR) responsive hydrogels: Advancements in precision drug delivery","authors":"Tejasvi Pandey ,&nbsp;Vivek Pandey","doi":"10.1016/j.jddst.2025.106682","DOIUrl":"10.1016/j.jddst.2025.106682","url":null,"abstract":"<div><div>Near-Infrared (NIR)-responsive hydrogels have emerged as an advanced class of smart materials with significant potential for precise, spatiotemporally controlled drug delivery via external NIR light stimulation. These hydrogels leverage the unique attributes of NIR light, including deep tissue penetration and minimal damage to surrounding tissues, thus offering substantial advantages in biomedical applications. This review presents an in-depth analysis of the underlying mechanisms of NIR-responsive hydrogels, including photothermal effects, photochemical reactions, and phase transition processes, which facilitate the controlled release of therapeutic agents. Recent advances in the synthesis and functionalization of these hydrogels are explored, with a focus on their application in targeted drug delivery for cancer therapy, where localized heating enables site-specific drug release, minimizing off-target effects. Additional applications in wound healing, Cancer therapy and transdermal drug delivery are also reviewed, emphasizing the hydrogels' ability to deliver bioactive molecules such as growth factors or drugs in response to external stimuli. Despite their promising potential, several challenges hinder the clinical translation of NIR-responsive hydrogels, including concerns regarding the biocompatibility and long-term stability of nanomaterials, as well as the need for precise control over drug release kinetics. This review critically addresses these challenges and discusses emerging strategies to overcome them, providing insights into future directions for the field. Material innovations and advancements in nanotechnology are expected to play a pivotal role in enhancing the performance and clinical applicability of NIR-responsive hydrogels.</div></div>","PeriodicalId":15600,"journal":{"name":"Journal of Drug Delivery Science and Technology","volume":"106 ","pages":"Article 106682"},"PeriodicalIF":4.5,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143378086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}