Journal of Drug Delivery Science and Technology最新文献

{"title":"Self-assembled carrier-free drug nanoparticles for enhanced synergistic therapy of liver cancer","authors":"Xingzhen Huang ,&nbsp;Lizhen Feng ,&nbsp;Jinping Huang ,&nbsp;Shengjun Liu ,&nbsp;Yao Wang ,&nbsp;Dongyi Huang ,&nbsp;Tingting Huang ,&nbsp;Weiju Liao ,&nbsp;Runfang Deng","doi":"10.1016/j.jddst.2026.108102","DOIUrl":"10.1016/j.jddst.2026.108102","url":null,"abstract":"<div><div>Carrier-free nanodrug delivery systems, composed entirely of active drug molecules, represent a sustainable approach for next-generation nanodrug technologies.This study utilizes hydroxycamptothecin (HCPT), curcumin (CUR), and glycyrrhizic acid (GA) to construct a ternary, carrier-free self-assembled nanoparticle system (GA/CUR/HCPT-NPs). It investigates the in vivo transport processes in cells and animals, evaluates the synergistic anti-liver cancer efficacy, and assesses toxicity in both in vivo and in vitro models. The findings provide valuable insights for the development of carrier-free, green nanodrug delivery systems. Molecular dynamics (MD) simulation snapshots confirmed that GA, CUR, and HCPT molecules associate through intermolecular forces, including van der Waals interactions and hydrogen bonding. The GA/CUR/HCPT-NPs had a size of 146.37 ± 0.157 nm, a polydispersity index (PDI) of 0.157 ± 0.010, and a zeta potential of −34.43 ± 0.771 mV, indicating good stability during storage at 4 °C for 7 days. Compared to the single-drug group and the physical mixture, GA/CUR/HCPT-NPs significantly enhanced cytotoxicity and uptake efficiency in Huh7 and BEL-7404 liver cancer cells. Additionally, GA/CUR/HCPT-NPs exhibited strong synergistic anti-liver cancer effects in vivo and in vitro, without notable liver or kidney toxicity. Thus, carrier-free ternary nanoparticles, prepared using a simple and effective green strategy, offer promising strategy for combination antitumor therapy.</div></div>","PeriodicalId":15600,"journal":{"name":"Journal of Drug Delivery Science and Technology","volume":"119 ","pages":"Article 108102"},"PeriodicalIF":4.9,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146162059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Silk-based piezoelectric biomaterials: Next-generation smart scaffolds for tissue regeneration and biomedical applications","authors":"Joydeep Bhattacharyya,&nbsp;Trishna Bal","doi":"10.1016/j.jddst.2026.108125","DOIUrl":"10.1016/j.jddst.2026.108125","url":null,"abstract":"<div><div>The convergence of materials science and regenerative medicine has spurred the development of advanced biomaterials capable of actively directing cellular behavior. Silk proteins, renowned for their superlative biocompatibility, precisely controllable biodegradation, and formidable mechanical resilience, have emerged as a frontier material in this domain. This review elucidates recent, significant advancements in harnessing the intrinsic piezoelectricity of silk proteins to create “smart” biopolymeric scaffolds for tissue regeneration. We comprehensively discuss the molecular origins of silk's electromechanical properties and survey the state-of-the-art fabrication techniques, including electrospinning and 3D printing, used to develop functional devices for wearable and implantable biomedical applications. A central focus is the synthesis of high-performance hybrid materials that amplify therapeutic electrical stimulation, thereby enhancing osteogenesis, guiding neural growth, and improving tissue integration. While acknowledging challenges in scalability and long-term <em>in vivo</em> stability, this review establishes that silk-based piezoelectric platforms represent a transformative technology. By converting physiological mechanical forces into regenerative electrical cues, these intelligent scaffolds hold immense promise for engineering complex tissues and restoring biological function, heralding a new era of personalized, effective therapeutic strategies.</div></div>","PeriodicalId":15600,"journal":{"name":"Journal of Drug Delivery Science and Technology","volume":"118 ","pages":"Article 108125"},"PeriodicalIF":4.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146172290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A multidimensional strategy combining surface science, release kinetics, and morphology to guide sustained-release tablet development","authors":"Andres C. Arana-Linares ,&nbsp;Alvaro Barrera-Ocampo ,&nbsp;Constain H. Salamanca","doi":"10.1016/j.jddst.2026.108087","DOIUrl":"10.1016/j.jddst.2026.108087","url":null,"abstract":"<div><div>This study investigates the relationship between surface thermodynamic properties and drug release kinetics in galantamine–HPMC compressed matrices. An integrated experimental strategy was applied, encompassing excipient compatibility (FTIR, DSC), particle and flow characterization, surface energy analysis (contact angle, OWRK model), kinetic modeling, and morphological documentation (SEM, real-time imaging). FTIR and DSC confirmed molecular dispersion and absence of incompatibilities. The matrix exhibited intermediate wettability (θ = 71.83°, SFET = 31.58 mJ/m²), influencing hydration and gel formation. Drug release followed a triphasic mechanism—latency, active diffusion, and erosion—best described by heuristic models, particularly the Gompertz model (R² = 0.9984), with similarly high fits for the Weibull, Logistic, and modified Hill models (R² ≥ 0.997). SEM and macroscopic imaging revealed progressive structural evolution, validating the proposed release dynamics. These findings demonstrate that surface attributes critically modulate hydration and drug transport, offering rational design criteria for modified-release oral systems. Studies integrating spectroscopic, thermodynamic, kinetic, and morphological dimensions remain scarce, highlighting the relevance and novelty of this approach.</div></div>","PeriodicalId":15600,"journal":{"name":"Journal of Drug Delivery Science and Technology","volume":"118 ","pages":"Article 108087"},"PeriodicalIF":4.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146172371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synergistic dissolving microneedle-tranexamic acid nanofibrous patch as a dual-phase delivery system for sustained release in melasma therapy","authors":"Bingqi Chen ,&nbsp;Jing Liu ,&nbsp;Ying Lin,&nbsp;Xiangfei Jin,&nbsp;Yiran Liu,&nbsp;Bingyuan Chen,&nbsp;Chengxu Diao,&nbsp;Xinmiao Li,&nbsp;Rong Chen,&nbsp;Weiyang Shen","doi":"10.1016/j.jddst.2026.108103","DOIUrl":"10.1016/j.jddst.2026.108103","url":null,"abstract":"<div><div>Melasma, a refractory pigmentation disorder, is conventionally managed by tyrosinase (TYR) inhibitors and combination therapies. Tranexamic acid (TA) has been demonstrated as a potent TYR inhibitor for melasma based on pharmacological and clinical studies. However, TA-loaded therapy faces dual hurdles, low transdermal delivery efficiency due to its strong polarity and the risks of systemic side effects such as fatal thrombosis. This study develops a novel and sustained-release TA transdermal system which is easily fabricated using dissolving hydrophilic polyvinylpyrrolidone microneedles (PVP-DMNs) covered by TA-polymer blending electrospun nanofibrous membrane. The PVP-DMNs are designed to effectively penetrate skin, subsequently forming localized micro reservoirs of dissolved PVP polymers facilitating sustained release therapy of drug, meanwhile the optimized polycaprolactone (PCL)/PVP nanofibers ensure amorphous dispersion of TA in the nanofibers which can enable sustained release in the micro-reservoirs formed by micro arrays. This dual-phase micro-nano mechanism achieved 40% higher cumulative transdermal delivery than standalone nanofibers, while extending the time to reach equilibrium to 8 h compared to drug-loaded microneedles alone. Biosafety of the TA-PVP-DMNs was confirmed with &gt;85% fibroblast viability post residual solvent removal. In UVB-induced melasma mice, TA-PVP-DMNs reduced epidermal melanin and suppressed tyrosinase expression, outperforming conventional nanofibrous membranes. Collectively, the system establishes an effective dual-phase TA delivery in melasma therapy which synergizes microneedle-induced microchannels for rapid permeation with nanofibrous reservoirs for prolonged release.</div></div>","PeriodicalId":15600,"journal":{"name":"Journal of Drug Delivery Science and Technology","volume":"118 ","pages":"Article 108103"},"PeriodicalIF":4.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146172327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Engineered exosomal delivery of semaglutide activates SIRT1–FOXO3a–miR-124 signaling and protects against cortical neuroinflammation","authors":"Elsayed A. Elmorsy ,&nbsp;Sameh Saber ,&nbsp;Ahmed Y. Kira ,&nbsp;Manal Mohamed Hatem ,&nbsp;Mohammed Alorini ,&nbsp;Suzan Awad AbdelGhany Morsy ,&nbsp;Hamad Alsaykhan ,&nbsp;Abdulaziz A. Alsalloom ,&nbsp;Nahla B. Mohamed ,&nbsp;Norah Suliman Alsoqih ,&nbsp;Rabab S. Hamad ,&nbsp;Youssef El-Sayed ,&nbsp;Nagwa Mahmoud Ramadan ,&nbsp;Mostafa M. Khodeir ,&nbsp;Ahmad H. Alhowail ,&nbsp;Enas A. Mohamed ,&nbsp;Amira Karam Khalifa","doi":"10.1016/j.jddst.2026.108078","DOIUrl":"10.1016/j.jddst.2026.108078","url":null,"abstract":"<div><div>Cortical neuroinflammation is one of the key contributors to neuronal dysfunction and cognitive decline in neurodegenerative disorders. Yet effective brain-targeted therapies remain limited by poor blood brain barrier (BBB) permeability. Here, we demonstrate the neuroprotective potential of semaglutide (SMG) and mesenchymal stem cell–derived exosomes (MSC-EXs). We integrated both agents into a single brain-targeted delivery platform. Bone marrow–derived MSCs were isolated and characterized. Their exosomes were purified and loaded with SMG using an optimized sonication-based method. This approach achieved an encapsulation efficiency of 84.69 ± 0.46 %. SMG-EXs preserved vesicle integrity and surface phenotype and exhibited a controlled, diffusion-based release profile. In vivo, exosomal encapsulation significantly enhanced SMG brain delivery, increasing C_max by ∼4.3-fold and overall brain exposure (AUC₀–∞) by ∼3.1-fold vs free SMG. Brain-targeting indices confirmed a preferential shift in SMG distribution toward the CNS, establishing MSC-EXs as an efficient vehicle for SMG delivery across the BBB. In an AlCl₃-induced cortical neuroinflammation model, SMG-EXs, but not free SMG, markedly restored cortical redox balance, lowered amyloid-β (Aβ) and p-Tau levels, reduced pro-inflammatory cytokines and apoptotic markers, and improved Morris water maze performance. These effects were accompanied by reactivation of the SIRT1–FOXO3a–PGC-1α and BDNF/miR-124 axes, indicating pathway-level engagement beyond simple drug delivery. Unloaded EXs conferred only partial protection, whereas SMG-EXs consistently produced the greatest structural, biochemical, and behavioral benefits. Collectively, these findings identify MSC-EXs as a promising carrier to unlock the CNS potential of SMG and introduce SMG-EXs as a mechanistically targeted, disease-modifying strategy for cortical neuroinflammation.</div></div>","PeriodicalId":15600,"journal":{"name":"Journal of Drug Delivery Science and Technology","volume":"118 ","pages":"Article 108078"},"PeriodicalIF":4.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146172283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nano-transfersomal hydrogel of Curcuma xanthorrhiza essential oil: Formulation, characterization, and evaluation of their bioactivities in vitro and in vivo","authors":"Lolyta Fitri Mustati ,&nbsp;Krishnan Raguvaran ,&nbsp;Harris Antonius ,&nbsp;Tia Okselni ,&nbsp;Sofna DS. Banjarnahor ,&nbsp;Yuli Widiyastuti ,&nbsp;Yuandani Yuandani ,&nbsp;Bayu Eko Prasetyo ,&nbsp;Eldiza Puji Rahmi ,&nbsp;Marissa Angelina ,&nbsp;Rizna Triana Dewi ,&nbsp;Nurul Arfiyanti Yusuf ,&nbsp;Abdi Wira Septama","doi":"10.1016/j.jddst.2026.108090","DOIUrl":"10.1016/j.jddst.2026.108090","url":null,"abstract":"<div><div>Bacterial infection, inflammation, and excessive oxidative stress can significantly delay wound healing. To overcome the limitations of the volatile and unstable <em>Curcuma xanthorrhiza</em> essential oil, a transfersomal hydrogel strategy was developed. This study aimed to formulate an optimal <em>C. xanthorrhiza</em> essential oil-loaded transfersomal hydrogel to enhance both <em>in vitro</em> and <em>in vivo</em> wound healing. The <em>in vitro</em> bioactivities evaluated included antibacterial, anti-inflammatory, and antioxidant properties for both the <em>C. xanthorrhiza</em> essential oil-loaded transfersomes and the free essential oil. Transfersomes were prepared using the thin layer hydration method. The optimal phosphatidylcholine-Tween 80 ratio (95:5) was selected based on <em>in vitro</em> bioactivity, stability, and drug release studies, and the transfersomes were then incorporated into a carbomer-based hydrogel. The <em>in vitro</em> bioactivity of the hydrogel was assessed, followed by <em>in vivo</em> wound healing studies. The optimized transfersomes achieved an encapsulation efficiency of 90.38 ± 1.51% for the essential oil, with a particle size of 112.83 ± 0.06 nm, a polydispersity index of 0.66 ± 0.02, and a zeta potential of −27.0 ± 0.1 mV. The transfersomes remained stable after five freeze thaw cycles. Enhanced antibacterial, anti-inflammatory, and antioxidant activities were observed in the transfersome formulation compared to the free essential oil. The <em>C. xanthorrhiza</em> essential oil-loaded transfersomal hydrogel provided improved wound healing and suppressed bacterial infection in an <em>in vivo</em> infected wound model. This study demonstrates that encapsulation of <em>C. xanthorrhiza</em> essential oil in transfersomes significantly increases its bioactivity when formulated as a hydrogel.</div></div>","PeriodicalId":15600,"journal":{"name":"Journal of Drug Delivery Science and Technology","volume":"118 ","pages":"Article 108090"},"PeriodicalIF":4.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146172287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Formulation and optimization of ubrogepant-loaded liposomal in-situ nasal gel for intranasal delivery to treat acute migraine: in-vitro characterization and in-vivo preclinical evaluation","authors":"Dibyalochan Mohanty ,&nbsp;Gorigae Venkata Narasimharao ,&nbsp;Jitendra Debata ,&nbsp;Gnyana Ranjan Parida ,&nbsp;Ameeduzzafar Zafar ,&nbsp;Omar A. Alsaidan ,&nbsp;Sami I. Alzarea ,&nbsp;Mohammad Khalid ,&nbsp;Naveed Ahmad","doi":"10.1016/j.jddst.2026.108073","DOIUrl":"10.1016/j.jddst.2026.108073","url":null,"abstract":"<div><div>The intranasal route is attractive for delivering drugs to the brain for treating diseases like migraine, as it offers a high surface area, avoids first-pass metabolism, and bypasses the blood-brain barrier. The present study aimed to develop an intranasal delivery system using Ubrogepant (UBP)-loaded liposome (LIS) <em>in-situ</em> gel for the treatment of migraine. The LIS were prepared by thin-film hydration method and optimized using the Box-Behnken design. FTIR confirmed the compatibility among LIS contents and encapsulation of UBP in LIS matrix. The optimized UBPLIS (UBPLIS9) exhibited a vesicle size of about 194.1 nm, a zeta potential of −30.5 mV, and an encapsulation efficiency (EE) of 83.4 %. The UBPLIS9 was incorporated into gellan gum <em>in-situ</em> gel. The optimized UBPLIS9 <em>in-situ</em> gel (UBPLIS9IG3) demonstrated excellent viscosity, spreadability, mucoadhesive strength, and gelling strength with uniform UBP content. UBPLIS9IG3 exhibited sustained release of UBP (89.5 ± 3.5 % over 12 h), significantly higher permeation through nasal mucosa (1.42-fold) compared to pure UBPIG, and was compatible with nasal mucosa in histopathological examination. Intranasally administered UBPLIS9IG3 demonstrated a considerably higher Cmax (572.6 ± 30.6 ng/mL) in the brain compared to UBP dispersion (212.6 ± 7.5 ng/mL). UBPLIS9IG3 also exhibited significantly higher antimigraine activity than UBP dispersion, as confirmed by the tail suspension and forced swim tests. Based on these findings, it can be concluded that the UBP-liposome loaded <em>in-situ</em> gel is a potential carrier for intranasal delivery for the treatment of migraine.</div></div>","PeriodicalId":15600,"journal":{"name":"Journal of Drug Delivery Science and Technology","volume":"118 ","pages":"Article 108073"},"PeriodicalIF":4.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146172288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Platycodon grandiflorus-loaded solid dispersion via hot-melt extrusion: A novel delivery system for mitigating allergic skin inflammation","authors":"Hye-Min Kim ,&nbsp;Junho Lee ,&nbsp;Ju-Yeon Lee ,&nbsp;Hyeok Byeon ,&nbsp;Ji-Hoon Choi ,&nbsp;Young-Cheol Lee ,&nbsp;Jong-Suep Baek ,&nbsp;Hyo-Jin An","doi":"10.1016/j.jddst.2026.108101","DOIUrl":"10.1016/j.jddst.2026.108101","url":null,"abstract":"<div><div>Skin dermatitis is sustained by dysregulated immune activation and barrier dysfunction, underscoring the need for practical, multi-target interventions with improved efficacy profiles. Guided by network pharmacology, we tested whether hot-melt extrusion (HME), a continuous solvent-free processing approach, can potentiate the anti-dermatitic activity of <em>Platycodon grandiflorus</em> (PG). We prepared an HME-processed PG formulation (PGH) and compared it with conventionally prepared PG across DNCB-induced dermatitis in NC/Nga mice, TNF-α/IFN-γ–stimulated HaCaT keratinocytes, and LPS-stimulated RAW264.7 macrophages. <em>In vivo</em>, PGH more effectively mitigated dermatitis severity and key pathophysiologic features, including elevated serum IgE, epidermal hyperplasia, and mast cell infiltration. <em>In vitro</em>, PGH produced broader suppression of pro-inflammatory outputs, reducing cytokine release in keratinocytes and attenuating NO production and iNOS expression in macrophages under inflammatory challenge. Across models, the enhanced activity of PGH was associated with reduced TLR4 abundance and attenuation of NF-κB pathway activation, consistent with dampened inflammatory mediator production. Collectively, these findings support HME processing as a scalable strategy to enhance PG-derived anti-inflammatory activity in dermatitis models and provide a mechanistic basis for formulation-dependent efficacy.</div></div>","PeriodicalId":15600,"journal":{"name":"Journal of Drug Delivery Science and Technology","volume":"118 ","pages":"Article 108101"},"PeriodicalIF":4.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146172370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Coamorphous system of tamoxifen and curcumin: Tailored release, synergism and enhanced pharmacological outcomes to combat breast cancer","authors":"Nagamalli Naga Sidhartha ,&nbsp;Soumyajit Dey ,&nbsp;Shrilekha Chilvery ,&nbsp;Anamika Sharma ,&nbsp;Chandraiah Godugu ,&nbsp;Amol G. Dikundwar","doi":"10.1016/j.jddst.2026.108076","DOIUrl":"10.1016/j.jddst.2026.108076","url":null,"abstract":"<div><div>The therapeutic potential of Tamoxifen, a frontline drug in the treatment of breast cancer is limited by its poor aqueous solubility and limited bioavailability resulting in sub-optimal therapeutic benefits. Herein, we report a novel coamorphous system of tamoxifen with rational-driven selected coformer curcumin demonstrating dual-function role, wherein stabilizing tamoxifen in its amorphous state with boosted anticancer activity. The coamorphous phase was extensively characterized using PXRD, modulated DSC, and IR spectroscopy and was also found to be stable as revealed by accelerated and long term stability studies. The modified form showed significant improvement in the solubility and dissolution compared to the pristine drug. <em>Ex vivo</em> gut sac permeability revealed greater intestinal permeability while <em>in vivo</em> pharmacokinetic profile in female SD rats demonstrated improved oral bioavailability with prolonged T_max showing extended systemic drug exposure. Remarkably, excellent synergism was noted between the components, wherein the bioavailability of tamoxifen was enhanced by curcumin and vice versa. <em>In vitro</em> pharmacological assays using MCF-7 breast cancer cells showed enhanced ROS generation, mitochondrial membrane disintegration, and flow cytometry analysis revealed early onset of apoptosis and cell cycle arrest at G0/G1 phase. Western blotting analysis further confirmed modulation of key apoptotis related proteins, Bcl-2, Bax, and Caspase-3 revealing the pro-apoptotic activity of CAM system. The modified formulation was found to be superior in suppressing cell migration and proliferation of the cancer cells. <em>In vitro</em> biocompatibility assays in non cancerous cells and haemolytic assays revealed CAM has good tolerability and safety profile. These findings prove the potential of the modified coamorphous form as a promising strategy for developing synergistically effective formulation of tamoxifen, offering superior therapeutic outcomes compared to the pristine drug in the treatment of breast cancer therapy.</div></div>","PeriodicalId":15600,"journal":{"name":"Journal of Drug Delivery Science and Technology","volume":"118 ","pages":"Article 108076"},"PeriodicalIF":4.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146102470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"pH-responsive PLGA nanoparticles enable sustained curcumin release and preserve mitochondrial bioenergetics in cardiomyocytes","authors":"Vytenis Keturakis ,&nbsp;Ozgul Gok ,&nbsp;Deimantė Puzinovė ,&nbsp;Zbignevas Balion ,&nbsp;Milda Kairytė ,&nbsp;Ineta Žukauskaitė ,&nbsp;Deimantė Kulakauskienė ,&nbsp;Deniz Gol ,&nbsp;Ernesta Pilnikovaitė ,&nbsp;Rimantas Benetis ,&nbsp;Edgaras Stankevičius ,&nbsp;Vaiva Lesauskaitė ,&nbsp;Daniel Benyamin ,&nbsp;Aistė Jekabsone","doi":"10.1016/j.jddst.2026.108075","DOIUrl":"10.1016/j.jddst.2026.108075","url":null,"abstract":"","PeriodicalId":15600,"journal":{"name":"Journal of Drug Delivery Science and Technology","volume":"118 ","pages":"Article 108075"},"PeriodicalIF":4.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146170243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}