Journal of Drug Delivery Science and Technology最新文献

{"title":"Stimuli-responsive nanovesicles for spatiotemporal control of drug delivery in chronic cutaneous wounds: Bridging molecular pathobiology to translational nanomedicine","authors":"Mohammad Qutub ,&nbsp;Amol Tatode ,&nbsp;Zeenat Iqbal ,&nbsp;Ujban Md Hussain ,&nbsp;Jayshree Taksande ,&nbsp;Rahmuddin Khan ,&nbsp;Deepak Thakre ,&nbsp;Tanvi Premchandani ,&nbsp;Milind Umekar ,&nbsp;Sameer Sheikh","doi":"10.1016/j.jddst.2025.107238","DOIUrl":"10.1016/j.jddst.2025.107238","url":null,"abstract":"<div><div>Chronic skin wounds remain a challenging clinical problem due to persistent inflammation, poor blood vessel growth, and biofilm infections that impede healing. Traditional therapies often lack the precision for targeted drug delivery, limiting their effectiveness. In response, stimuli-responsive nanovesicles have emerged as a promising alternative. These carriers are engineered to release drugs in response to unique biochemical and biophysical signals in the wound environment. They react to internal cues such as acidic pH, oxidative stress, and elevated protease activity, as well as external triggers like near-infrared light or ultrasound. For example, pH-sensitive polymer matrices and oxidation-labile linkers have been developed to protect drugs and ensure precise release at the target site. Surface modifications with integrin-binding peptides and zwitterionic coatings improve cellular uptake and reduce immune detection, extending therapeutic action. Advances in preclinical evaluation now include 3D-bioprinted skin models and microfluidic organ chips that simulate real wound conditions, allowing detailed study of nanoparticle penetration and biological activity. Murine studies have further supported these findings by demonstrating reduced bacterial colonization and improved tissue regeneration via tracking the immune responses. However, challenges such as scaling up production and meeting stringent regulatory standards remain. Future integration with smart bandages and machine learning may further optimize drug release and dosing, paving the way for more effective chronic wound care.</div></div>","PeriodicalId":15600,"journal":{"name":"Journal of Drug Delivery Science and Technology","volume":"112 ","pages":"Article 107238"},"PeriodicalIF":4.5,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144548341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Implementation of design of experiments in liposome manufacturing: ethanol injection and extrusion as a case study","authors":"Mariana Biscaia-Caleiras ,&nbsp;Joana Fiteiro ,&nbsp;Diana Lopes ,&nbsp;Tiago Fidalgo ,&nbsp;Ana Sofia Lourenço ,&nbsp;João Nuno Moreira ,&nbsp;Sérgio Simões","doi":"10.1016/j.jddst.2025.107236","DOIUrl":"10.1016/j.jddst.2025.107236","url":null,"abstract":"<div><div>Although substantial advancements in microfluidics and continuous manufacturing have been made, particularly for lipid nanoparticles (LNPs) used in nucleic acid delivery, conventional liposomes for small-molecule drugs pose distinct challenges. These formulations are typically manufactured via ethanol injection followed by extrusion, a two-step process unlike the integrated nature of microfluidics. This separation introduces additional complexity, as individual unit operations may influence each other, making early-stage optimization more difficult and often requiring iterative refinement across the process. Scaling up these conventional methods remains a challenge, especially in achieving reproducibility, scalability, and regulatory compliance.</div><div>Design of Experiments (DoE) provides a valuable framework for understanding and optimizing such processes. However, in the early development stages, particularly in industry, its use is often limited by high material costs, time-consuming analyses, and the need for timely decision-making. Moreover, the existing literature rarely offers detailed, practical guidance tailored to formulation scientists working under these constraints.</div><div>This study presents an objective, step-by-step application of DoE to early-phase liposomal formulation development at the 100 mL scale. The goal is not to build highly predictive models, but to rapidly identify robust, workable conditions that enable progression to later development stages. This pragmatic approach reflects the interdependence of manufacturing steps, where downstream processes, such as tangential flow filtration and remote drug loading, may influence or negate prior optimizations.</div><div>By evaluating key parameters like ethanol content, stirring speed, and extrusion conditions, the study offers a practical roadmap for resource-conscious process development, supporting informed decision-making in real-world industrial settings.</div></div>","PeriodicalId":15600,"journal":{"name":"Journal of Drug Delivery Science and Technology","volume":"112 ","pages":"Article 107236"},"PeriodicalIF":4.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144534340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unveiling the therapeutic potential of Fisetin: Bridging traditional knowledge with modern medicine","authors":"Umesh B. Telrandhe ,&nbsp;Darshan R. Telange ,&nbsp;Vijay Mishra ,&nbsp;Alaa A.A. Aljabali ,&nbsp;Yachana Mishra","doi":"10.1016/j.jddst.2025.107232","DOIUrl":"10.1016/j.jddst.2025.107232","url":null,"abstract":"<div><div>Fisetin (FIS), a pharmacologically active flavonoid present in various fruits and vegetables including strawberries, apples, and persimmons, has attracted considerable attention owing to its broad-spectrum pharmacological activities. Having been traditionally utilized as an antioxidant and anti-inflammatory agent in herbal medicine, FIS is now being developed as a novel therapeutic agent in modern pharmacology. Its wide biological activities involve neuroprotection, antidiabetic, antiobesity, antiatherosclerotic, and significant anticancer activity against lung cancer, colon cancer, prostate cancer, pancreatic cancer, and skin cancer. These activities are mediated through various pathways involving mTOR, Wnt/β-catenin, NF-κB, and TRAIL-induced apoptosis, making FIS a multitargeted pharmacological agent. However, poor solubility and poor bioavailability remain major hurdles in its clinical application. Several novel delivery vehicles including self-nano emulsifying drug delivery systems (SNEDDS), liposomes, ethanol-based delivery vesicles (ethosomes), glycerosomal delivery systems (glycerosomes), and polymeric nanocarriers have been evaluated as vehicles to overcome these limitations. These vehicles significantly increase the solubilizing capacity, stability, and pharmacological efficacy of FIS. Clinical trials have now started evaluating its safety and efficacy in treating osteoarthritis, COVID-19, and chronic kidney disease. This review discusses comprehensively the traditional origin, pharmacodynamic activity, therapeutic applications of FIS, and recent advances in technology involving its formulation vehicles as strong evidence enough to warrant further research as a multipurpose pharmaceutical agent.</div></div>","PeriodicalId":15600,"journal":{"name":"Journal of Drug Delivery Science and Technology","volume":"112 ","pages":"Article 107232"},"PeriodicalIF":4.5,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144519147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intradermal delivery of nanohybrid thermosensitive hydrogels loaded with chondroitin sulphate coated pomegranate lipid carriers via hollow microneedles for effective rheumatoid arthritis management","authors":"Mariam Zewail ,&nbsp;Haidy Abbas ,&nbsp;Nesrine El Sayed ,&nbsp;Nihal M. El Newehy ,&nbsp;Heba Abd-El-Azim","doi":"10.1016/j.jddst.2025.107234","DOIUrl":"10.1016/j.jddst.2025.107234","url":null,"abstract":"<div><div>Rheumatoid Arthritis (RA) is a common inflammatory arthritis type that significantly affects physical functions, leading to restrictions in daily activities. The current study aims to develop an effective nano-based drug delivery system for RA management using pomegranate peel extract (POM). POM was encapsulated in nanostructured lipid carriers (NLCs), coated with chondroitin sulphate (CHS) to actively target CD44 receptors that are over expressed in rheumatic joints. The optimized NLCs were loaded into Pluronic F127 hydrogels to prepare thermosensitive nanohybrid hydrogels for intradermal administration via AdminPen™ MNs hollow microneedles (Ho-MNs). The UPLC-ESI-MS/MS analysis of POM identified 76 compounds, predominantly polyphenols, known for anti-inflammatory and antioxidant properties. NLCs were prepared using the melt emulsification method, showing particle sizes ranging from 64.7 ± 0.34 to 341 ± 2.5 nm, zeta potentials between −17 ± 1.34 mV and −30 ± 0.98 mV, and high entrapment efficiencies (96.34 ± 0.34–98.89 ± 0.12 %). Nanohybrid hydrogels extended the release period of POM from 6 days to 13 days and reduced burst effects. <em>Ex vivo</em> studies confirmed effective skin penetration by AdminPen™ MNs. <em>In vivo</em> studies in rats with AIA demonstrated that POM nanohybrid hydrogels significantly relieved joint swelling and reduced TNF-α, IL-1β, MDA, and MMP-3 levels, while increasing NRF2 level. Histopathological examination revealed that the nanohybrid hydrogel-treated group had normal joint and cartilage structure. This novel system offers a minimally invasive, sustained-release approach for RA treatment, enhancing bioavailability and the therapeutic efficacy of POM, thus providing a promising alternative to conventional therapies.</div></div>","PeriodicalId":15600,"journal":{"name":"Journal of Drug Delivery Science and Technology","volume":"112 ","pages":"Article 107234"},"PeriodicalIF":4.5,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144548339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An in-silico, in-vitro, and in-vivo analysis of hyaluronic acid embedded fucoidan capped silver nanoparticles against periodontal pathogen","authors":"Ritu Mahanty ,&nbsp;Debasmita Dubey ,&nbsp;Ivy Saha ,&nbsp;Rakesh Kumar Sahoo ,&nbsp;Guru Prasanna Sahoo ,&nbsp;Tushar Kanti Rajwar ,&nbsp;Bibhanwita Satpathy ,&nbsp;Jitu Halder ,&nbsp;Ajit Mishra ,&nbsp;Deepak Pradhan ,&nbsp;Priyanka Dash ,&nbsp;Chandan Das ,&nbsp;Salim Manoharadas ,&nbsp;Muralidhar Tata ,&nbsp;Biswakanth Kar ,&nbsp;Goutam Ghosh ,&nbsp;Goutam Rath","doi":"10.1016/j.jddst.2025.107228","DOIUrl":"10.1016/j.jddst.2025.107228","url":null,"abstract":"<div><div>Increasing prevalence of antibiotic resistance among Periodontitis (PDs)-associated microbes poses a significant concern to treatment. Resistance mechanisms, including biofilm and β-lactamase production, hinder disease management. Silver nanoparticles (AgNPs) have been widely explored due to their broad-spectrum antimicrobial properties against resistant microbes. Microbial colonization and the complexity of biofilm in dentin canals limit the permeability of AgNPs and their efficacy. Biosurfactant-mediated AgNPs hold great potential for treating PD-associated infections. In this study, <em>Staphylococcus aureus</em> (<em>S. aureus</em>) was isolated from PDs patients, identified, and characterized by molecular sequencing. AgNPs were prepared using Fucoidan (FN), as it displayed higher binding affinity towards biofilm protein-bap (−3.965) and β- β-lactamase protein-AmpC (−4.331) of <em>S. aureus</em>. The AgNPs were further embedded with Hyaluronic acid (HA) to form a hydrogel matrix. The hydrogel was characterized using various analytical techniques such as UV, SEM, EDX, TEM, FTIR, DSC, DLS and XRD. Stabilized cubic-shaped FN-AgNPs (−36 mV) with a small diameter (85 ± 0.8 nm) exhibited good dispersion (FE-SEM) in HA-matrix and enhanced physicochemical properties. <em>In-Vitro</em> assays suggest the significant antimicrobial (MIC-62.5 μg/mL), antibiofilm (&gt;80 %), and β-lactamase inhibition potential of HA-FN-AgNPs over NB-AgNPs (<em>p</em> ≤ 0.001) against <em>S. aureus</em> without marked cytotoxicity in HGF-1 (∼96 %). Further, <em>In-Vivo</em> findings revealed the superior antimicrobial efficacy, greater mucoadhesion (64 ± 0.56 %) and longer retention efficacy (up to 6 h) of the hydrogel with additional anti-inflammatory properties, suppressing the expression of proinflammatory cytokines (IL-6, IL-1β, and TNF-α), and enhanced drug delivery to PDs pocket. From this study, we conclude that FN-coated-AgNPs synthesized from <em>U. pinnatifida</em> have tremendous potential in drug development.</div></div>","PeriodicalId":15600,"journal":{"name":"Journal of Drug Delivery Science and Technology","volume":"112 ","pages":"Article 107228"},"PeriodicalIF":4.5,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144548340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multi-scale study on the volatility of essential oil and its modulation methods","authors":"Xinhui Peng ,&nbsp;Weishuo Ren ,&nbsp;Mingyue Jia ,&nbsp;Qing Zhou ,&nbsp;Bingxuan Li ,&nbsp;Guoqing Li ,&nbsp;Yueyang Xie ,&nbsp;Xingxing Dai ,&nbsp;Hui Cao ,&nbsp;Xinyuan Shi","doi":"10.1016/j.jddst.2025.107227","DOIUrl":"10.1016/j.jddst.2025.107227","url":null,"abstract":"<div><div>Essential oil (EO), a mixture of volatile components with diverse pharmacological effects, faces challenges due to volatility impacting therapeutic efficacy. To address this, we developed an integrated multiscale methodology combining simultaneous thermal analysis, gas chromatography, and molecular dynamics simulations. This approach quantitatively explores EO component volatility and elucidates the mechanisms by which fixatives (nerolidol, farnesol, ethyl cinnamate) and 13X-HP zeolite encapsulation modulate volatilization. Our findings demonstrate that volatility is primarily governed by molecular structural class, molecular weight, and functional groups. Based on volatility parameters (e.g., T_max ranging from 124.1 °C to 260.0 °C, volatilization in 12 h ranging from 33.12 % to 100 %, etc.), EO components were categorized into top (&gt;95 % volatilization in 2 h), middle, and base (&lt;50 % volatilization after 12 h) notes, providing a choice basis for duration-specific aromatherapy. Notably, low-volatility EOs showed potential as fixatives. Mechanistic insights revealed that the ethyl cinnamate prolongs the volatilization of representative EO components by 10.76 %–24.02 % through polarity-modulated intermolecular interactions modulated by polarity, irrespective of its own volatility. For zeolite encapsulation, 13X-HP exhibited pore-size (∼10 Å) dependent effects: effectively delaying the release of smaller monoterpenes (e.g., ocimene volatilization decreased 3.95 %) but unexpectedly accelerating the release of larger components (e.g., citral volatilization increased 12.59 %). The modulated release was governed by adsorption location, component characteristics, and adsorption energy (&lt;−31470.4 kJ/mol correlating with longer release). Critically, the strong concordance between macroscopic experiment data and microscopic simulations validates this integrated methodology as a powerful tool for the rational selection of EO components and the design of controlled-release systems.</div></div>","PeriodicalId":15600,"journal":{"name":"Journal of Drug Delivery Science and Technology","volume":"112 ","pages":"Article 107227"},"PeriodicalIF":4.5,"publicationDate":"2025-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144522701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Interaction between bovine serum albumin and Solutol® HS 15 micelles: A two-stage and concentration-dependent process” [J. Drug Deliv. Sci. Technol. 64 (2021) 102376]","authors":"Fangqin Fu ,&nbsp;Zhengwei Huang ,&nbsp;Wenhua Wang ,&nbsp;Wenhao Wang ,&nbsp;Xiangyu Ma ,&nbsp;Lei Wang ,&nbsp;Ying Huang ,&nbsp;Ping Hu ,&nbsp;Xin Pan ,&nbsp;Chuanbin Wu","doi":"10.1016/j.jddst.2025.107176","DOIUrl":"10.1016/j.jddst.2025.107176","url":null,"abstract":"","PeriodicalId":15600,"journal":{"name":"Journal of Drug Delivery Science and Technology","volume":"112 ","pages":"Article 107176"},"PeriodicalIF":4.5,"publicationDate":"2025-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144511138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of theranostic nanoparticles in dental infectious diseases: A review","authors":"Mitra Rostami ,&nbsp;Pouria Farahani ,&nbsp;Moslem Karimzadeh ,&nbsp;Samar Esmaelian ,&nbsp;Abbas Fadel Hussein ,&nbsp;Kamyar Nasiri ,&nbsp;Hareth A. Alrikabi ,&nbsp;Naghmeh Shenasa","doi":"10.1016/j.jddst.2025.107223","DOIUrl":"10.1016/j.jddst.2025.107223","url":null,"abstract":"<div><div>The mouth cavity is a natural habitat for various microorganisms, many of which serve as a source of resources for pathogenic germs that may lead to systemic, local, oral, and dental diseases. The overuse, overprescription, and excess of antimicrobials lead to the emergence of resistant bacteria. As it is a quick and sensitive diagnosis, efficient and low-toxic therapies are desperately needed. Theranostics, the term for simultaneous diagnosis and treatment, has made nanomaterials indispensable. Nanoparticles (NPs) are being explored in dentistry for their potential to improve the diagnosis, prevention, and treatment of dental infectious illnesses such as periodontitis, peri-implantitis (PIs), and root canal infections. They can enhance antimicrobial activity, improve drug delivery, and enhance the effectiveness of dental materials. Furthermore, developments in nanotechnology have enhanced the sensitivity and quick identification of biomarkers for periodontal and oral disorders. The treatment and diagnosis aspects of dental infectious diseases, including periodontitis, PIs, and root canal infections, are covered in this article. Moreover, research was done on several theranostic NP kinds' therapeutic and diagnostic potential for periodontal and dental illnesses. The study's assessment of the literature demonstrated how advances in nanotheranostics-based diagnosis and treatment are being made to address and lessen the current shortcomings in the widely used techniques for diagnosing and treating infectious dental disorders.</div></div>","PeriodicalId":15600,"journal":{"name":"Journal of Drug Delivery Science and Technology","volume":"112 ","pages":"Article 107223"},"PeriodicalIF":4.5,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144522528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing drug delivery in migraine therapy: A study on natural small molecule co-assembly","authors":"Wenhua Wang ,&nbsp;Xin Lu ,&nbsp;Zhipeng Xu ,&nbsp;Long Chen ,&nbsp;Wei Lu ,&nbsp;Jiacheng Wang ,&nbsp;Min Xu","doi":"10.1016/j.jddst.2025.107230","DOIUrl":"10.1016/j.jddst.2025.107230","url":null,"abstract":"<div><div>Migraine is one of the most common and debilitating neurological disorders worldwide, and neurogenic inflammation is thought to be a key factor. More recently, natural carrier-free co-assemblies of small molecules have been shown to be an effective new type of therapeutic system. This study developed nanoparticles co-assembled with oleanolic acid (OA) and evodiamine (Evo), based on active ingredients from traditional Chinese medicine, with a particle size of approximately 380 nm and a surface charge of approximately −14.6 mV. The analysis of the assembly mechanism shows that the co-assembly of OA and Evo (OA-Evo CNPs) is mainly mediated by hydrogen bonding interactions, π-π stacking and hydrophobic interactions. The physicochemical characterisation demonstrated that the OA-Evo CNPs exhibited favourable hydrophilic properties, slow-release characteristics, and <em>in vitro</em> safety. The co-assembly of nanoparticles has been demonstrated to exert a substantial improvements effect on nitroglycerin-induced migraine-like behaviour in mouse models, as evidenced by the observation of significant improvements in biochemical (NO, 5-HT, and CGRP, etc) and inflammatory markers (TNF-α、IL-1β and IL-6) in the plasma, along with a notable reduction in microglia activation within the brain tissue of test subjects. This study proposes a strategy for co-assembly of natural small molecules and highlights the synergistic effect of the combined plant compounds.</div></div>","PeriodicalId":15600,"journal":{"name":"Journal of Drug Delivery Science and Technology","volume":"112 ","pages":"Article 107230"},"PeriodicalIF":4.5,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144522530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tailoring a salep-g-p(VP-co-AA)/Ag NPs superabsorbent single network hydrogel for enhanced pH-responsive delivery of deferasirox","authors":"Ghasem Rezanejade Bardajee ,&nbsp;Hossein Mahmoodian ,&nbsp;Mahnaz Rouhi","doi":"10.1016/j.jddst.2025.107222","DOIUrl":"10.1016/j.jddst.2025.107222","url":null,"abstract":"<div><div>Iron overload disorders pose significant therapeutic challenges due to the poor aqueous solubility, gastric instability, and erratic bioavailability of conventional Deferasirox (DFX) formulations. To address these limitations, a pH-responsive nanocomposite superabsorbent single network hydrogel (SNH), comprising salep-grafted p (VP-co-AA) with embedded Ag NPs, was developed as an oral delivery system for DFX. This SNH exhibits pH-dependent properties, maintaining structural integrity and restricting drug release at pH 2.0 (gastric conditions) while achieving sustained release of up to 94 % over 12 h at pH 6.0–7.4 (intestinal conditions). Optimization of synthesis parameters, including ratios of salep, VP to AA, and Ag NPs, yielded a superabsorbent material with a swelling capacity of 755.6 g/g. Characterization via FT-IR, TGA-DTG, DSC, XPS, XRD, EDX, FESEM, TEM, and AFM confirmed successful grafting, uniform Ag NPs distribution, and a robust 3D network structure. This system enhances DFX bioavailability and efficacy by preventing premature degradation in acidic environments and ensuring targeted intestinal release, reducing systemic toxicity. Additionally, SNH offers a versatile platform for the controlled, stimuli-responsive delivery of various bioactive agents.</div></div>","PeriodicalId":15600,"journal":{"name":"Journal of Drug Delivery Science and Technology","volume":"112 ","pages":"Article 107222"},"PeriodicalIF":4.5,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144513600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}