Journal of Drug Delivery Science and Technology最新文献

筛选
英文 中文
Effective light-driven inactivation of Escherichia coli with ammonium porphyrin-based photosensitizers 卟啉铵基光敏剂对大肠杆菌的有效光致失活研究
IF 4.9 3区 医学
Journal of Drug Delivery Science and Technology Pub Date : 2025-07-24 DOI: 10.1016/j.jddst.2025.107323
SaraR.D. Gamelas , RaquelM.A.D. Tavares , Inês Chaves , MariaA.F. Faustino , Adelaide Almeida , LeandroM.O. Lourenço
{"title":"Effective light-driven inactivation of Escherichia coli with ammonium porphyrin-based photosensitizers","authors":"SaraR.D. Gamelas ,&nbsp;RaquelM.A.D. Tavares ,&nbsp;Inês Chaves ,&nbsp;MariaA.F. Faustino ,&nbsp;Adelaide Almeida ,&nbsp;LeandroM.O. Lourenço","doi":"10.1016/j.jddst.2025.107323","DOIUrl":"10.1016/j.jddst.2025.107323","url":null,"abstract":"<div><div>Antimicrobial resistance (AMR) is a major threat to global health, predicted to cause 10 million deaths each year by 2050. AMR occurs when humans and animals' pathogenic bacteria do not respond to antimicrobial treatments. Utilising the interplay between light, dioxygen, and photosensitizers (PSs), photodynamic inactivation (PDI) of microorganisms offers a non-invasive, non-toxic, and repeatable alternative for pathogens control. In this study, cationic free-base and zinc(II) porphyrins bearing tris(trimethylammoniummethyl)phenoxy groups (H<sub>2</sub>Por <strong>1a</strong> and ZnPor <strong>1b</strong>, respectively) were synthesized, characterised, and evaluated for photoinactivation of <em>Escherichia coli</em>. The photophysical properties of H<sub>2</sub>Por <strong>1a</strong> and ZnPor <strong>1b</strong> generated high levels of singlet oxygen (<sup>1</sup>O<sub>2</sub>) species under light irradiation at 418 nm (Ф<sub>Δ</sub> = 0.44 and 0.65), photostability (70–84 %), and stability (87–99 %), evidencing their potential to be applied as PSs. The antibacterial PDI efficacy was examined with <strong>1a</strong> and <strong>1b</strong> (1.0 and 5.0 μM) in the presence and absence of KI (100 mM) at 50 mW cm<sup>−2</sup>, during 60 min of light exposure. PSs <strong>1a</strong> and <strong>1b</strong> displayed high PDI performance with <em>E. coli</em> viability reduction until the method's detection limit (reductions of &gt;3.9 log<sub>10</sub> RLU.mL<sup>−1</sup>). Adding KI co-adjuvant, the PDI effect was maximised in a short period of light exposure (15 min), allowing a reduction of the total light dose (from 135 J cm<sup>−2</sup> and 90 J cm<sup>−2</sup> to 45 J cm<sup>−2</sup>) and PS concentration (from 5.0 to 1.0 μM). These findings highlight the PDI performance of PSs, demonstrating their potential as antimicrobial agents against Gram-negative bacterial infections.</div></div>","PeriodicalId":15600,"journal":{"name":"Journal of Drug Delivery Science and Technology","volume":"113 ","pages":"Article 107323"},"PeriodicalIF":4.9,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144724718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nanoform hydroxyapatite in bone-regenerative medicine & associated adverse effects 纳米羟基磷灰石在骨再生医学及相关的不良反应
IF 4.5 3区 医学
Journal of Drug Delivery Science and Technology Pub Date : 2025-07-24 DOI: 10.1016/j.jddst.2025.107326
Koyeli Girigoswami , Agnishwar Girigoswami
{"title":"Nanoform hydroxyapatite in bone-regenerative medicine & associated adverse effects","authors":"Koyeli Girigoswami ,&nbsp;Agnishwar Girigoswami","doi":"10.1016/j.jddst.2025.107326","DOIUrl":"10.1016/j.jddst.2025.107326","url":null,"abstract":"<div><div>Although bone-tissue engineering holds great promise for healing or repairing severe bone injury, a number of barriers prevent its application in clinical settings. Because they mimic the body's natural bone minerals, scaffolds composed of nanohydroxyapatite (HA-N), a biomaterial that has been the subject of much research, have attracted interest. This mimicking behavior promotes bone formation and remineralization. The biocompatible nature of HA-N interacts positively with bone tissue, aiding osteoblasts in their work and increasing the production of genes that promote bone formation without causing any negative side effects or inflammation. Recent research has focused on tailoring HA-N characteristics, such as size, shape, and dose, to optimize its performance in vivo. Specifically, smaller particle sizes have shown more significant benefits, while higher doses have caused negative effects. Despite extensive studies, the precise structure-activity relationship and long-term safety of HA-N-based biomaterials remain incompletely understood in biological systems. The current review examines the role of HA-N in bone regeneration, its interactions with cells, and recent advancements in composite doping and the development of HA-N/polymer hybrid scaffolds. The most recent developments, current constraints, and open issues are highlighted in particular, underscoring the need for a more thorough mechanistic understanding and standardized assessment procedures to inform future clinical applications.</div></div>","PeriodicalId":15600,"journal":{"name":"Journal of Drug Delivery Science and Technology","volume":"113 ","pages":"Article 107326"},"PeriodicalIF":4.5,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144712991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Innovative therapeutic potential of C60 fullerene in nanomedicine C60富勒烯在纳米医学中的创新治疗潜力
IF 4.5 3区 医学
Journal of Drug Delivery Science and Technology Pub Date : 2025-07-24 DOI: 10.1016/j.jddst.2025.107315
Aryan Faraj , Farhang Hameed Awlqadr , Ashna Ahmed , Hassan Hama Amin , Zhia Haidar , Syamand Ahmed Qadir , Miran Qadir , Amjad Qadir , Sozyar Mahmood , Aveen Shirwan Saeed , Somayyeh Ebrahimzadeh , Vida Vahdanikia , Mohammad Khalaj-Kondori , Abolfazl Barzegar
{"title":"Innovative therapeutic potential of C60 fullerene in nanomedicine","authors":"Aryan Faraj ,&nbsp;Farhang Hameed Awlqadr ,&nbsp;Ashna Ahmed ,&nbsp;Hassan Hama Amin ,&nbsp;Zhia Haidar ,&nbsp;Syamand Ahmed Qadir ,&nbsp;Miran Qadir ,&nbsp;Amjad Qadir ,&nbsp;Sozyar Mahmood ,&nbsp;Aveen Shirwan Saeed ,&nbsp;Somayyeh Ebrahimzadeh ,&nbsp;Vida Vahdanikia ,&nbsp;Mohammad Khalaj-Kondori ,&nbsp;Abolfazl Barzegar","doi":"10.1016/j.jddst.2025.107315","DOIUrl":"10.1016/j.jddst.2025.107315","url":null,"abstract":"<div><div>Recently, C60 fullerene has become a focus of nanomedicine research due to its unique carbon allotrope structure, excellent biocompatibility, and high antioxidant properties, as well as its potential for drug delivery. Another breakthrough is the functionalization of C60 fullerene, which will enhance its solubility in various solvents. C60 fullerene is a suitable carrier for drugs in various areas of biomedical research, including antivirals and other antimicrobials, anticancer agents, and radioprotective agents or reactive oxygen species scavengers. The employment of C60 fullerene in new applications will focus on neuroprotection, anti-ageing approaches, and revolutionary methods for treating diseases without cytotoxicity. Moreover, C60 fullerene holds the potential for a substantial impact on optical imaging and biosensing, and may serve as a photosensitizer for photodynamic therapy. C60 fullerene exhibits a complex toxicity profile as both an antioxidant and a pro-oxidant. The dual behavior of C60 fullerene, functioning as both a molecule and a nanoparticle, highlights its flexibility in various applications and complicates the understanding of its actual impact. Concerns about toxicity and biodegradability persist in medical treatment; further research is crucial to comprehensively elucidate its therapeutic potential, resolve adverse effects, optimise its safety, and explore innovative applications in nanotechnology.</div></div>","PeriodicalId":15600,"journal":{"name":"Journal of Drug Delivery Science and Technology","volume":"113 ","pages":"Article 107315"},"PeriodicalIF":4.5,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144712992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nanotechnology-driven approaches for the management of Huntington's disease 纳米技术驱动的亨廷顿舞蹈病治疗方法
IF 4.5 3区 医学
Journal of Drug Delivery Science and Technology Pub Date : 2025-07-23 DOI: 10.1016/j.jddst.2025.107318
Mohd Shahrukh, Umme Jiba, Mohammad Arif Khan, Saima Amin, Farhan Jalees Ahmad, Nazeer Hasan
{"title":"Nanotechnology-driven approaches for the management of Huntington's disease","authors":"Mohd Shahrukh,&nbsp;Umme Jiba,&nbsp;Mohammad Arif Khan,&nbsp;Saima Amin,&nbsp;Farhan Jalees Ahmad,&nbsp;Nazeer Hasan","doi":"10.1016/j.jddst.2025.107318","DOIUrl":"10.1016/j.jddst.2025.107318","url":null,"abstract":"<div><div>Huntington's disease (HD) is a progressive neurodegenerative disorder caused by an autosomal dominant mutation in the huntingtin (HTT) gene, resulting in protein aggregation, neuronal dysfunction, and cell death. Advance therapies for HD increasingly focus on integrating nanotechnology, gene editing, stem cell strategies, and immunotherapy. Nanotechnology-based delivery systems, such as liposomal, polymeric, and metallic nanoparticles, enhance the precision and efficiency of drug delivery, reducing off-target effects and improving the bioavailability of therapeutic agents, and targeting mutant HTT (mHTT). Gene editing tools, particularly CRISPR/Cas9, aim to specifically silence or correct the HTT mutation, presenting a potential one-time solution for HD. Stem cell approaches, including induced pluripotent stem cells (iPSCs) and neural progenitor cells, show promise in replacing damaged neurons and restoring functional neural networks. Immunotherapies, such as monoclonal antibodies like C6–17, target mtHTT aggregates to mitigate neurodegeneration and prevent disease progression. These strategies offer a synergistic approach to address HD's multifaceted pathology. This integrated paradigm represents a significant advancement in HD research, paving the way for innovative and personalized therapeutic solutions.</div></div>","PeriodicalId":15600,"journal":{"name":"Journal of Drug Delivery Science and Technology","volume":"113 ","pages":"Article 107318"},"PeriodicalIF":4.5,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144704702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fmoc-amino acid conjugated self-assembling gemcitabine nanoparticles against cancers with enhanced pharmacokinetic profile fmoc -氨基酸共轭自组装吉西他滨纳米颗粒抗肿瘤增强药代动力学特征
IF 4.5 3区 医学
Journal of Drug Delivery Science and Technology Pub Date : 2025-07-23 DOI: 10.1016/j.jddst.2025.107316
Farha Bano , Shalini Kumari , Aman Kumar Mahto , Saumya Sharma , Jamshed Haneef , Jairam Meena , Asif Husain , Rikeshwer Prasad Dewangan
{"title":"Fmoc-amino acid conjugated self-assembling gemcitabine nanoparticles against cancers with enhanced pharmacokinetic profile","authors":"Farha Bano ,&nbsp;Shalini Kumari ,&nbsp;Aman Kumar Mahto ,&nbsp;Saumya Sharma ,&nbsp;Jamshed Haneef ,&nbsp;Jairam Meena ,&nbsp;Asif Husain ,&nbsp;Rikeshwer Prasad Dewangan","doi":"10.1016/j.jddst.2025.107316","DOIUrl":"10.1016/j.jddst.2025.107316","url":null,"abstract":"<div><div>Gemcitabine is a nucleoside analogue used primarily in the treatment of various cancers. Gemcitabine is administered intravenously due to its poor oral bioavailability. Gemcitabine is metabolized mainly in the liver by deaminases to its inactive form, so the preparation of new conjugates is required to enhance the pharmacokinetic properties. In this work we have synthesized three conjugates (GWC, GPC, GLC) by linking gemcitabine's 4-amino group with Fmoc-protected tryptophan, phenylalanine, and leucine. These conjugates self-assembled into carrier-free nanoparticles, exhibiting hydrodynamic radii between 154 nm and 191 nm, confirmed by dynamic light scattering and high-resolution transmission electron microscopy. <em>In vitro</em> studies demonstrated a biological responsive release of gemcitabine from these nanoparticles in the presence of plasma, suggesting targeted drug release. Notably, the conjugates exhibited superior anticancer activity against MCF-7 and HepG2 cancer cell lines compared to the parent drug. Further investigation revealed that the cellular uptake of these conjugates is independent of nucleoside transporters, a mechanism that could mitigate the development of drug resistance commonly associated with gemcitabine. Pharmacokinetic analysis in a rat model showed a significant increase in the half-life and other key pharmacokinetic parameters of gemcitabine when administered as these conjugates. This work highlights a promising strategy for the design and development of carrier-free nanoparticle systems for gemcitabine delivery, offering improved efficacy and potentially reducing the incidence of drug resistance in cancer treatment.</div></div>","PeriodicalId":15600,"journal":{"name":"Journal of Drug Delivery Science and Technology","volume":"113 ","pages":"Article 107316"},"PeriodicalIF":4.5,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144704705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Development of sublingual melatonin nanofibers in enhancing the anticancer effects of doxorubicin, in vitro and in vivo studies 舌下褪黑素纳米纤维在增强阿霉素抗癌作用中的发展,体外和体内研究
IF 4.5 3区 医学
Journal of Drug Delivery Science and Technology Pub Date : 2025-07-23 DOI: 10.1016/j.jddst.2025.107304
Saba Shahgordi , Nima Nosratzadeh , Ehsan Kaffash , Sina Dehestani , Bahareh Ansari , Somayeh Marouzi , Mohammadreza Abbaspour , Maryam Hashemi
{"title":"Development of sublingual melatonin nanofibers in enhancing the anticancer effects of doxorubicin, in vitro and in vivo studies","authors":"Saba Shahgordi ,&nbsp;Nima Nosratzadeh ,&nbsp;Ehsan Kaffash ,&nbsp;Sina Dehestani ,&nbsp;Bahareh Ansari ,&nbsp;Somayeh Marouzi ,&nbsp;Mohammadreza Abbaspour ,&nbsp;Maryam Hashemi","doi":"10.1016/j.jddst.2025.107304","DOIUrl":"10.1016/j.jddst.2025.107304","url":null,"abstract":"<div><div>Combination therapy based on nanosystems has been considered as a potential strategy to increase the effects of chemotherapeutic agents and reduce their cytotoxicity. Melatonin (ML) is a natural body hormone that exhibits anticancer effects through different mechanisms such as antioxidant activity, apoptosis induction, and immune system modulation. In this study, the ML sublingual nanofiber formula was designed to improve its physicochemical properties. In addition, the anticancer efficacy of doxorubicin in combination with ML nanofiber was evaluated. Nanofibers were prepared using the electrospinning method and characterized. The best formulation containing 1 %w/v ML, and 8 %w/v polyvinyl pyrrolidone, was chosen for further research. <em>In vitro</em> cytotoxicity of co-treated of ML nanofibers and doxorubicin was assessed using MTT test on the C26 cell line. <em>In vivo</em> studies involved sublingual administration of ML nanofibers (20 mg/kg/day) and doxorubicin (5 mg/kg as a single IV dose) in a model of C26 tumor-bearing mice for 21 days. Our study demonstrated that ML nanofiber possesses appropriate physicochemical properties. The dissolution test revealed that the optimal nanofiber completely dissolved in PBS as a substitute for saliva within 90 s. It also showed a synergic effect with doxorubicin on the colorectal cell line as well as lower side effects in the animal studies, especially cardiotoxicity compared to free doxorubicin. The present study concluded that co-administration of ML via sublingual nanofibers enhances the therapeutic efficacy of doxorubicin offering a promising strategy for combination cancer therapy.</div></div>","PeriodicalId":15600,"journal":{"name":"Journal of Drug Delivery Science and Technology","volume":"113 ","pages":"Article 107304"},"PeriodicalIF":4.5,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144712993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Development of permeation enhancer-Co-loaded solid lipid nanoparticles for enhanced oral bioavailability of alendronate 提高阿仑膦酸钠口服生物利用度的渗透增强剂-共载固体脂质纳米颗粒的研制
IF 4.5 3区 医学
Journal of Drug Delivery Science and Technology Pub Date : 2025-07-23 DOI: 10.1016/j.jddst.2025.107320
Chaeyeon Kim , Seohyeon Han , Yuyoung Joo , Hyunjin Kim , Yu Seok Youn , Jin-Ki Kim , Han-Gon Choi , Yuseon Shin , Chaemin Lim , Kyung Taek Oh
{"title":"Development of permeation enhancer-Co-loaded solid lipid nanoparticles for enhanced oral bioavailability of alendronate","authors":"Chaeyeon Kim ,&nbsp;Seohyeon Han ,&nbsp;Yuyoung Joo ,&nbsp;Hyunjin Kim ,&nbsp;Yu Seok Youn ,&nbsp;Jin-Ki Kim ,&nbsp;Han-Gon Choi ,&nbsp;Yuseon Shin ,&nbsp;Chaemin Lim ,&nbsp;Kyung Taek Oh","doi":"10.1016/j.jddst.2025.107320","DOIUrl":"10.1016/j.jddst.2025.107320","url":null,"abstract":"<div><div>Alendronate, marketed under the brand name Fosamax®, is a bisphosphonate that has been actively used in the clinical setting for the treatment of bone disease. However, the low intestinal permeability and bioavailability of alendronate significantly limit its therapeutic effectiveness. We developed alendronate/permeation enhancer co-loaded solid lipid nanoparticles (SLNs) composed of Compritol® 888 ATO or Gelot™ 64, Span 20, and F108, and demonstrated that the SLN formulation improved drug intestinal permeability with an excellent P<sub>app</sub> value. Salcaprozate sodium (SNAC) was selected as the permeation enhancer because it enhanced drug transport across Caco-2 cell monolayers. Through the X-ray diffraction and differential scanning calorimetry, it was confirmed that both drugs were encapsulated in SLNs. Moreover, the alendronate/SNAC co-loaded SLNs exhibited a sustained-release profile, offering the potential to extend the therapeutic effects and reduce the dosing frequency, which is crucial for long-term osteoporosis treatment. Subsequently, the freeze-drying process improved the storage stability of SLNs, increasing their commercialization potential. This study demonstrates how SLNs and permeability enhancers can be used to bypass the drawbacks of the drug with poor permeability.</div></div>","PeriodicalId":15600,"journal":{"name":"Journal of Drug Delivery Science and Technology","volume":"113 ","pages":"Article 107320"},"PeriodicalIF":4.5,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144694730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Herbal bioactive loaded chitosan therapeutics: A promising strategy for wound healing 草药生物活性负载壳聚糖治疗:一种有前途的伤口愈合策略
IF 4.5 3区 医学
Journal of Drug Delivery Science and Technology Pub Date : 2025-07-23 DOI: 10.1016/j.jddst.2025.107321
Abhisek Panigrahi , Jitu Halder , Vineet Kumar Rai , Priyanka Dash , Chandan Das , Biswakanth Kar , Manoj Kumar Sarangi , Goutam Ghosh , Goutam Rath
{"title":"Herbal bioactive loaded chitosan therapeutics: A promising strategy for wound healing","authors":"Abhisek Panigrahi ,&nbsp;Jitu Halder ,&nbsp;Vineet Kumar Rai ,&nbsp;Priyanka Dash ,&nbsp;Chandan Das ,&nbsp;Biswakanth Kar ,&nbsp;Manoj Kumar Sarangi ,&nbsp;Goutam Ghosh ,&nbsp;Goutam Rath","doi":"10.1016/j.jddst.2025.107321","DOIUrl":"10.1016/j.jddst.2025.107321","url":null,"abstract":"<div><div>Wound healing remains a critical medical challenge due to the limitations of conventional therapies, including cytotoxicity, antimicrobial resistance, and poor targeting of healing phases. Herbal bioactives—curcumin, resveratrol, gallic acid, rutin, catechin, lawsone, and naringenin—offer multifaceted therapeutic potential, including antibacterial and antioxidant effects, reduction of pro-inflammatory cytokines (TNF-α, IL-6), enhancement of collagen synthesis, promotion of fibroblast proliferation, and inhibition of microbial biofilms. However, their clinical application is hindered by poor bioavailability, short retention time, poor permeability, rapid degradation, and poor solubility. Chitosan-based formulations effectively address these challenges by enhancing solubility, stability, and enabling controlled release. The synergistic effects of chitosan and herbal constituents are a double-edged sword in the wound-healing process. Comparative studies underscore the superiority of chitosan-herbal systems over synthetic antibiotics, offering low cytotoxicity, targeted biofilm disruption, and holistic healing through angiogenesis promotion, inflammation modulation, and collagen deposition. While herbal bioactive-loaded chitosan formulations show significant promise for wound healing, their broader clinical implementation faces several notable drawbacks. These include challenges in achieving consistent availability at the site of action and stability for practical application, alongside concerns regarding potential toxicity from the carrier system. Moreover, the claim of pharmacological activities for chitosan significantly enhances the regulatory requirements. Hurdles related to large-scale synthesis, batch-to-batch variability, and stringent regulatory constraints currently impede their widespread clinical translation and commercialization. This review underscores the transformative potential of integrating natural bioactives with chitosan carriers, providing a biocompatible, multi-mechanistic approach to overcome traditional therapeutic limitations and significantly enhance regenerative outcomes.</div></div>","PeriodicalId":15600,"journal":{"name":"Journal of Drug Delivery Science and Technology","volume":"113 ","pages":"Article 107321"},"PeriodicalIF":4.5,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144702561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effervescence-modulated drug release from HPMC matrix tablets: Mechanistic insight and numerical estimation of water and ibuprofen diffusivity HPMC基质片泡腾调节药物释放:水和布洛芬扩散的机理和数值估计
IF 4.9 3区 医学
Journal of Drug Delivery Science and Technology Pub Date : 2025-07-23 DOI: 10.1016/j.jddst.2025.107285
Setthapong Senarat , Thawatchai Phaechamud , Pornsarp Pornsawad , Pornsit Chaiya
{"title":"Effervescence-modulated drug release from HPMC matrix tablets: Mechanistic insight and numerical estimation of water and ibuprofen diffusivity","authors":"Setthapong Senarat ,&nbsp;Thawatchai Phaechamud ,&nbsp;Pornsarp Pornsawad ,&nbsp;Pornsit Chaiya","doi":"10.1016/j.jddst.2025.107285","DOIUrl":"10.1016/j.jddst.2025.107285","url":null,"abstract":"<div><div>Effervescent matrix tablets offer a dynamic platform for controlling drug release by modulating water sorption, swelling, and matrix disintegration. This study presents a mechanistic and numerical framework to investigate the release kinetics of ibuprofen from hydroxypropyl methylcellulose (HPMC)-based matrices containing varying concentrations of effervescent agents. Under simulated gastric conditions (0.1 N HCl, pH 1.2), increased effervescence significantly enhanced water sorption and matrix porosity, accelerating drug release. To capture these effects quantitatively, a diffusion-based model was developed using Fick's second law in cylindrical coordinates, integrated with free volume theory to account for water-dependent diffusivity. A finite difference approach, coupled with Gauss–Newton optimization, was employed to estimate key diffusivity parameters with high precision. The model accurately reproduced experimental release profiles (R<sup>2</sup> &gt; 0.99) and revealed how effervescence and HPMC content synergistically regulate swelling behavior and diffusivity. Estimated water diffusion coefficients ranged from 5.23 × 10<sup>−4</sup> to 136.93 × 10<sup>−4</sup> cm<sup>2</sup>/min across formulations, highlighting formulation-dependent mass transport dynamics. These findings highlight the value of integrated computational and experimental approaches for guiding the rational design of effervescent-based controlled release systems and advance our understanding of formulation-structure-function relationships in oral drug delivery.</div></div>","PeriodicalId":15600,"journal":{"name":"Journal of Drug Delivery Science and Technology","volume":"113 ","pages":"Article 107285"},"PeriodicalIF":4.9,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144738357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Revolutionizing colon-targeted drug delivery: The pivotal role of lipid nano-carriers and their transformative modifications 革命性的结肠靶向药物递送:脂质纳米载体及其变革性修饰的关键作用
IF 4.9 3区 医学
Journal of Drug Delivery Science and Technology Pub Date : 2025-07-22 DOI: 10.1016/j.jddst.2025.107319
Yohan Baptista Adidharma Wilie , Maxius Gunawan , Yasmin Hadad , Delly Ramadon , Fadlina Chany Saputri , Phatsawee Jansook , Veerakiet Boonkanokwong , Raditya Iswandana
{"title":"Revolutionizing colon-targeted drug delivery: The pivotal role of lipid nano-carriers and their transformative modifications","authors":"Yohan Baptista Adidharma Wilie ,&nbsp;Maxius Gunawan ,&nbsp;Yasmin Hadad ,&nbsp;Delly Ramadon ,&nbsp;Fadlina Chany Saputri ,&nbsp;Phatsawee Jansook ,&nbsp;Veerakiet Boonkanokwong ,&nbsp;Raditya Iswandana","doi":"10.1016/j.jddst.2025.107319","DOIUrl":"10.1016/j.jddst.2025.107319","url":null,"abstract":"<div><div>A colon-targeted drug delivery system is preferred as a means of drug delivery towards the colon to treat several colon-specific diseases, particularly colon cancer and inflammatory bowel disease. Utilizing colon-targeted drug delivery systems may result in minimized premature drug release or degradation while at the same time increasing local colonic drug delivery. On the other hand, lipid nano-carrier is another alternative drug delivery system that can increase drug solubility, enhance drug permeation and retention, and offer its surface for further specific modification. Several lipid nano-carriers, such as nanoemulsion, liposome, lipid-polymer hybrid nanoparticle, solid lipid nanoparticle, and nanostructured lipid carrier, have already been or are potentially being used as colon-targeted drug delivery systems. Various applications of lipid nano-carriers in colon-targeted drug delivery system mechanisms have also been identified, both in their original and modified forms, namely pH-dependent, microflora-dependent, time-dependent, surface modification, and combination approaches. The combination of lipid nano-carriers and various colon-targeted drug delivery mechanisms offers several advantages, proven with <em>in vitro</em> and <em>in vivo</em> results. Several highlighted findings, such as increased drug solubility, permeability, and cellular uptake; controlled release profile, improved colon-targeted delivery, reduced side effects and toxicity; increased pharmacokinetics parameters (AUC, C<sub>max</sub>, T<sub>max</sub>, mean residence time); and positive pharacodynamic results have been reported. Based on these findings, modification of lipid nano-carriers for colon-targeted drug delivery system purposes offers a potential prospect in treating colon-specific diseases.</div></div>","PeriodicalId":15600,"journal":{"name":"Journal of Drug Delivery Science and Technology","volume":"113 ","pages":"Article 107319"},"PeriodicalIF":4.9,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144738242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信