Advancements in delivering RNA therapies using physical transdermal drug delivery methods

IF 4.9 3区医学 Q1 PHARMACOLOGY & PHARMACY

Journal of Drug Delivery Science and Technology Pub Date : 2025-09-30 DOI:10.1016/j.jddst.2025.107587

Sukaina Nimrawi , Nusaiba K. Al-nemrawi , Young M. Kwon

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Abstract

RNA therapies, including mRNA, siRNA, and miRNA, hold tremendous potential for treating various pathological conditions, ranging from cancer to genetic disorders. However, their successful clinical application depends on the development of efficient and patient-friendly delivery systems. This review explores advancements in physical transdermal drug delivery (TDD) methods as innovative platforms for delivering RNA therapeutics. Techniques such as microneedles, iontophoresis, electroporation, sonophoresis, jet injections, and laser radiation are highlighted for their ability to overcome traditional delivery challenges, enabling localized and systemic RNA delivery through the skin with enhanced stability, efficacy, controlled release, and reduced patient discomfort. The review provides a comprehensive overview of the principles, mechanisms, and advantages of these methods, along with a detailed summary of recent studies in the literature, highlighting future research and clinical application opportunities.

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利用物理透皮给药方法递送RNA疗法的进展

RNA疗法，包括mRNA、siRNA和miRNA，在治疗从癌症到遗传疾病的各种病理状况方面具有巨大的潜力。然而，它们的成功临床应用取决于高效和患者友好的输送系统的发展。本文综述了物理透皮给药（TDD）方法作为递送RNA治疗药物的创新平台的进展。微针、离子电泳、电穿孔、声电泳、喷射注射和激光辐射等技术因其克服传统递送挑战的能力而受到重视，使RNA通过皮肤局部和全身递送具有更高的稳定性、有效性、控释和减少患者不适。本文综述了这些方法的原理、机制和优势，并详细总结了最近的文献研究，强调了未来的研究和临床应用机会。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Drug Delivery Science and Technology 医学-药学

CiteScore

8.00

自引率

8.00%

发文量

879

审稿时长

94 days

期刊介绍： The Journal of Drug Delivery Science and Technology is an international journal devoted to drug delivery and pharmaceutical technology. The journal covers all innovative aspects of all pharmaceutical dosage forms and the most advanced research on controlled release, bioavailability and drug absorption, nanomedicines, gene delivery, tissue engineering, etc. Hot topics, related to manufacturing processes and quality control, are also welcomed.