Journal of Drug Delivery Science and Technology最新文献

{"title":"Ion-paired asiatic acid hydrogel facilitates high-quality wound healing through diverse synergistic effects","authors":"Mingming Li ,&nbsp;Suhong Fu ,&nbsp;Jiaxin Chen ,&nbsp;Xinxing Sun ,&nbsp;Yang Chen ,&nbsp;Lei Yang","doi":"10.1016/j.jddst.2026.108034","DOIUrl":"10.1016/j.jddst.2026.108034","url":null,"abstract":"<div><div>High-quality wound healing is a primary clinical goal, yet it remains difficult to achieve reliably with current treatments. For this purpose, this study developed an ion-paired asiatic acid (AA) hydrogel specially for wound healing and systematically evaluated its pharmacodynamic efficacy both in vitro and in vivo. The formulation strategy involved screening organic amines as counter-ions using an ex vivo stratum corneum-removed skin model. Triethanolamine was identified as the optimal counterion, maximizing AA penetration into local tissue while minimizing systemic permeation via the formation of an ion-pair as confirmed by Nuclear Magnetic Resonance. The resulting hydrogel exhibited ideal properties for wound application, as characterized by its water vapor transmission rate, swelling ratio, degradability ratio, and water retention. <em>In vitro</em>, the hydrogel accelerated wound closure by stimulating cellular proliferation and migration, promoting vascular differentiation, and exhibiting selective antibacterial efficacy against <em>S. aureus</em>. In a rat full-thickness skin defect model, the hydrogel effectively facilitated scarless healing, which was mechanistically linked to collagen remodeling (indicated by a higher proportion of type III relative to type I collagen), suppression of TNF-α-mediated inflammation, and downregulation of TGF-β-driven fibrosis. Collectively, this work establishes a strategically designed ion-pair hydrogel system that coordinates key healing processes, offering a promising strategy for achieving reliable, high-quality wound regeneration.</div></div>","PeriodicalId":15600,"journal":{"name":"Journal of Drug Delivery Science and Technology","volume":"117 ","pages":"Article 108034"},"PeriodicalIF":4.9,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146035464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Solubility enhancement of curcumin using PLA-grafted Hibiscus rosa-sinensis mucilage as a biocompatible amphiphilic copolymer","authors":"Biswasarathi Basak,&nbsp;Laxmi Kumari,&nbsp;Trishna Bal,&nbsp;Shreya Sharma,&nbsp;Akash Mondal,&nbsp;Joydeep Bhattacharyya","doi":"10.1016/j.jddst.2026.108033","DOIUrl":"10.1016/j.jddst.2026.108033","url":null,"abstract":"<div><div>Green synthesized biocompatible polymers of amphiphilic nature can be used for enhancing the solubility and permeability of BCS Class-IV drugs. Thus, different grades of novel polylactic acid (PLA) grafted <em>Hibiscus rosasinensis</em> leaf mucilage (HLM) amphiphilic graft copolymer (HLM-g-PLA) were synthesized for improving the solubility and permeability characteristics of drugs like Curcumin. Optimized grade G1 was characterized using FTIR, ¹³C NMR, TGA, XRD, OCA and DLS. The critical micelle concentration (CMC) of G1 was found to be low indicating surfactant properties which were evidenced by its ability to stabilize colloidal dispersion<em>. In vitro</em> drug release study revealed 62.86 % of curcumin (CUR) release for more than 20 h, indicating sustained release properties, following Korsmeyer-Peppas model, indicating nonfickian diffusion with n &gt; 0.5. The solubility and permeability of CUR were enhanced to 6.2013 ± 1.8142 μg/ml from 0.5254 ± 0.0342 μg/ml and 15.754 ± 0.7877 % respectively, in the presence of G1. The optimized grade G1 exhibited antimicrobial activity against <em>Staphylococcus aureus and Escherichia coli</em> with anti-inflammatory and hemocompatible properties<em>.</em> G1 also exhibited wound healing with no traces of scars and full hair growth within 11 days, indicating its biocompatible nature, thereby indicating the application of such natural polysaccharide modified amphiphilic graft copolymers as an effective pharmaceutical excipient.</div></div>","PeriodicalId":15600,"journal":{"name":"Journal of Drug Delivery Science and Technology","volume":"117 ","pages":"Article 108033"},"PeriodicalIF":4.9,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146035467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microneedling-enhanced kojic acid serum: A comprehensive study of retention, permeation, dermal targeting, and cytotoxicity","authors":"Jenifer Brasil dos Santos ,&nbsp;Gabriela Lopes Gama e Silva ,&nbsp;Letícia Coli Louvisse de Abreu ,&nbsp;Alice Simon ,&nbsp;João Gabriel Passos Rodrigues ,&nbsp;Vânia Emerich Bucco de Campos ,&nbsp;Elisabete Pereira dos Santos ,&nbsp;Hellena Keiko Toma ,&nbsp;Thiago da Silva Honório ,&nbsp;Lucio Mendes Cabral ,&nbsp;Carla Holandino ,&nbsp;Michelle Nonato de Oliveira Melo ,&nbsp;Giovanna Gomes Martins ,&nbsp;Gláucia Miranda Pinheiro ,&nbsp;Bárbara da Silva e Souza Lorca ,&nbsp;Zaida Maria Faria de Freitas","doi":"10.1016/j.jddst.2025.107901","DOIUrl":"10.1016/j.jddst.2025.107901","url":null,"abstract":"<div><div>Melasma is a chronic hyperpigmentation disorder primarily affecting sun-exposed facial areas, and kojic acid, a tyrosinase inhibitor, has shown promise in its management. This study evaluated the efficacy of a 2.0 % kojic acid serum (SKA2) combined with microneedling for Melasma treatment, comparing two microneedling devices: a roller and an electric pen.</div><div>The serum's stability, microbiological safety, and cytotoxicity assays were evaluated. Furthermore, ex vivo permeation and retention were analyzed using porcine ear skin and a twocompartment diffusion system. Results demonstrated that SKA2 exhibited the expected characteristics for kojic acid delivery. The samples evaluated showed good microbiological stability with no coliforms, <em>S. aureus</em>, or <em>P. aeruginosa</em>, and the count of colonies of microorganisms, molds, and yeasts was &lt;10 CFU/mL. Permeation assays revealed that microneedling significantly enhanced kojic acid delivery to the receptor fluid (p &lt; 0.05). Among the microneedling devices, the 0.5 mm roller showed the most effective retention of kojic acid in the skin, even though no significant difference was observed between tests on microneedling skin (p &lt; 0.05). No cytotoxic effects on keratinocytes or fibroblasts were demonstrated (cell viability &gt;70 %). Even though KA permeation occurs, its use in association with MN is considered safe.</div><div>In conclusion, MNappears to be promising in promoting the retention ofKAin the cutaneous strata, although no significant difference has been demonstrated between the devices used in different needle lengths, meaning that both rollers and electric pens can be used in association with SKA2 in the treatment of melasma.</div></div>","PeriodicalId":15600,"journal":{"name":"Journal of Drug Delivery Science and Technology","volume":"117 ","pages":"Article 107901"},"PeriodicalIF":4.9,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147397771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and optimization of a zein-coated inhalable HDAC inhibitor formulation as a potential treatment for idiopathic pulmonary fibrosis via three-fluid nozzle spray drying","authors":"Wei-Ren Ke,&nbsp;Sheng-Chieh Hsiao,&nbsp;Meng-Tsung Cheng,&nbsp;Chao-Wu Yu","doi":"10.1016/j.jddst.2026.108065","DOIUrl":"10.1016/j.jddst.2026.108065","url":null,"abstract":"<div><div>Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease with limited therapies. Histone deacetylase inhibitors have emerged as promising antifibrotic agents by modulating fibrogenic pathways. Localized pulmonary delivery is particularly important to maximize lung exposure while minimizing systemic toxicity. Dry powder inhalers offer advantages, including rapid delivery, portability, and patient adherence. In this study, an inhalable dry powder formulation of J27644, a selective HDAC6/HDAC8 inhibitor, was developed using three-fluid nozzle spray drying (3FNSD) with zein as a hydrophobic coating excipient and lactose as a bulking agent. Zein dissolved in ethanol was delivered through the middle channel of the nozzle, while J27644 and lactose co-dissolved in an ethanol-water cosolvent were introduced through the innermost channel. A Box-Behnken design was applied to optimize spray gas flow (600-1600 L/h), inlet temperature (50-150 °C), feeding rate (2-6 mL/min), and zein content (5-30 %). Zein content was identified as the dominant factor influencing surface coverage, while spray gas, inlet temperature, and zein content contributed to recrystallization resistance at 25 °C/40 % relative humidity (RH). The optimized 3FNSD formulation achieved a zein surface coverage of 79.6 % and negligible mass loss (0 %) at 25 °C/40 % RH, closely matching model predictions (82.6 % and 0 %). This formulation also exhibited an amorphous, raisin-like morphology with a D50 of 1.48 ± 0.00 μm. <em>In vitro</em> dispersion testing showed superior aerosolization for 3FNSD, with the highest emitted dose (177.0 ± 19.5 μg from a 300-μg load), fine particle dose (151.1 ± 18.0 μg), and the lowest mass median aerodynamic diameter (1.61 ± 0.02 μm), compared with controls prepared by two-fluid nozzle spray drying (2FNSD) and 2FNSD without zein. Dissolution testing demonstrated &gt;70 % release within 60 min for all formulations. Difference factor (f₁) analysis confirmed comparable dissolution between 2FNSD and 3FNSD (f₁ = 8.95), whereas the zein-free formulation released faster and deviated from 3FNSD (f₁ = 19.6). These findings demonstrate the feasibility of 3FNSD to produce zein-coated lactose-J27644 powders with enhanced moisture stability, favorable aerosolization, and preserved dissolution, supporting the application of zein and the three-fluid nozzle in spray-dried powder formulations for inhalation.</div></div>","PeriodicalId":15600,"journal":{"name":"Journal of Drug Delivery Science and Technology","volume":"117 ","pages":"Article 108065"},"PeriodicalIF":4.9,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146073702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Amphiphile-drug interplay: Enhanced solubility and drug-tailored self-assembly for delivery applications","authors":"Angela Cerulo,&nbsp;Nicola Antonio Di Spirito,&nbsp;Nino Grizzuti,&nbsp;Rossana Pasquino","doi":"10.1016/j.jddst.2026.108036","DOIUrl":"10.1016/j.jddst.2026.108036","url":null,"abstract":"<div><div>During the last three decades, the design of refined nanosized drug delivery systems employed peculiar temperature-responsive synthetic copolymers, Pluronics, capable to mimic biological systems. Biocompatibility and biodegradability, along with the possibility of opportunely tailoring the desired features of these macromolecules, can be exploited to develop carriers able to improve the solubility and the bioavailability of hydrophobic drugs. As passive agents, Pluronics have a high drug loading capacity in water and low immunogenicity, but they can also play a more active role by reacting to temperature changes. Within specific ranges of concentration, Pluronic aqueous solutions can be injected in liquid form and become soft solids at body temperature, allowing to modulate the drug release. The presence of additives can modify the thermal response of Pluronic molecules in water, possibly sensitizing the system to other stimuli (e.g., pH). In this work, the addition of hydrophobic Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) – ibuprofen (IBU), ibuprofen sodium salt (IBUNa), diclofenac potassium (DK) – in a 45 wt% Pluronic F68 aqueous solution was investigated by rheology, Differential Scanning Calorimetry (DSC), surface tension and wettability measurements. Pluronic F68 significantly increased the solubility of the drug in water. The thermo-reversible, self-assembling process was followed and phase transitions were identified through rheological oscillatory and steady measurements and calorimetric evaluations at different drug concentrations and temperatures. The effect of pH was also discussed by varying the drug type and its concentration. Lastly, empirical phase diagrams for the drug/Pluronic aqueous solutions were built.</div></div>","PeriodicalId":15600,"journal":{"name":"Journal of Drug Delivery Science and Technology","volume":"117 ","pages":"Article 108036"},"PeriodicalIF":4.9,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146074405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Drug delivery system based on phase change material: thermo-responsive controlled release and multimodal synergistic therapy","authors":"Xuelai Zhang,&nbsp;Zongpeng Li,&nbsp;Jun Ji","doi":"10.1016/j.jddst.2025.107967","DOIUrl":"10.1016/j.jddst.2025.107967","url":null,"abstract":"<div><div>Conventional cancer therapies suffer from severely constrained clinical efficacy due to severe off-target toxicity, prevalent multidrug resistance, and inherent limitations of monotherapy. Phase change materials (PCMs) provide novel paradigms to overcome these constraints through thermo-responsive controlled drug release and synergistic multimodal therapeutic mechanisms. PCMs exhibit inherent biocompatibility, biodegradability, high drug-loading capacity, tunable melting points, and cost-effectiveness, effectively preventing premature payload leakage while enabling controllable thermo-responsive release, thereby enhancing therapeutic efficacy. This review comprehensively addresses the construction methodologies and design principles of PCM-based nanoplatforms, which function as stringent gatekeepers and efficient payload delivery systems. It details innovative applications in combinatorial anticancer therapies including photothermal-chemotherapy, photodynamic therapy (PDT), and chemodynamic therapy (CDT). Furthermore, surface functionalization and microenvironment modulation strategies enhance tumor-selective accumulation and deep-tissue penetration efficiency. By systematically integrating the precision release attributes of PCMs with multimodal synergistic strategies, this work establishes new paradigms for overcoming tumor resistance and reducing systemic toxicity. Its extensible design framework and performance-boosting mechanisms hold significant promise for advancing clinical translation of next-generation intelligent drug delivery systems.</div></div>","PeriodicalId":15600,"journal":{"name":"Journal of Drug Delivery Science and Technology","volume":"117 ","pages":"Article 107967"},"PeriodicalIF":4.9,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145908706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dual release of miRNA-424-3p and doxorubicin using layer-by-layer stimuli-responsive dendritic mesoporous nanoparticles","authors":"Oznur Akbal Vural ,&nbsp;Tayfun Vural ,&nbsp;Vicente Martí-Centelles ,&nbsp;Estela Climent ,&nbsp;Alba García-Fernández ,&nbsp;Ramón Martínez-Máñez","doi":"10.1016/j.jddst.2026.107986","DOIUrl":"10.1016/j.jddst.2026.107986","url":null,"abstract":"<div><div>The prevalence of cancer is on the rise on a global scale, and lung cancer represents one of the most common types of cancer worldwide that leads to high cancer-related deaths. Over the past decade, nanotechnology has made tremendous progress in cancer treatment. Moreover, combination therapy, including chemotherapy and gene therapy, has turned out to be a promising strategy that could enhance therapeutic efficacy in the treatment of lung adenocarcinoma. The tumor-suppressive miRNA-424-3p has demonstrated to significantly downregulate galectin-3 (Gal3) which is an anti-apoptotic protein and highly expressed in A549 cells. This has been shown to promote apoptosis, decrease proliferation, and increase sensitivity to the chemotherapeutic drug doxorubicin (Dox). However, miRNA-424-3p-based combination therapies with Dox have not yet been reported. Since dendritic mesoporous silica nanoparticles (DMSNs) have the potential to act as carriers for nucleic acids and drugs simultaneously, in this study we have successfully introduced for the first time anti-Gal3 functionalized DMSNs for the co-delivery of miRNA-424-3p and Dox protected with a layer-by-layer polyethyleneimine and poly-L-lysine coating. Whereas there is no or minimal Dox and miRNA release under neutral pH from the nanoparticles, conversely, a significant delivery of Dox and miRNA is seen in lysosomal extract medium. The effects of the co-delivery system, i.e. miRNA-424-3p and Dox, on A549 cells is evaluated by analyzing cell proliferation, cellular uptake, cell apoptosis assay, and the expression of related proteins and genes. The results demonstrate that miRNA-424-3p effectively transfected into A549 lung cancer cells, dramatically reducing the expression of Gal3 at the protein level. Forward transfection of the cell line with the DMSN loaded with miRNA-424-3p and Dox causes both a decrease in cell viability and an increase in apoptosis induction. Our data shows that the designed DMSN has a good performance as a combined drug and gene delivery system for cancer therapy.</div></div>","PeriodicalId":15600,"journal":{"name":"Journal of Drug Delivery Science and Technology","volume":"117 ","pages":"Article 107986"},"PeriodicalIF":4.9,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145980839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A green strategy for resveratrol nanodelivery: A multidisciplinary approach for the physicochemical characterization of Thymus-based liposomes with anti-biofilm activity against Listeria monocytogenes","authors":"Maria Gioia Fabiano ,&nbsp;Linda Maurizi ,&nbsp;Jacopo Forte ,&nbsp;Eleonora D'Intino ,&nbsp;Maria Grazia Ammendolia ,&nbsp;Davide Corinti ,&nbsp;Astri D. Tagueha ,&nbsp;Michela Relucenti ,&nbsp;Orlando Donfrancesco ,&nbsp;Federica Rinaldi ,&nbsp;Maria Elisa Crestoni ,&nbsp;Stefania Garzoli ,&nbsp;Carlotta Marianecci ,&nbsp;Maria Carafa ,&nbsp;Catia Longhi","doi":"10.1016/j.jddst.2026.108027","DOIUrl":"10.1016/j.jddst.2026.108027","url":null,"abstract":"<div><div>Nanocarrier-based drug delivery systems (DDS) offer promising strategies to enhance therapeutic efficacy, stability, and targeted delivery of bioactive compounds while reducing side effects. In this study, a multidisciplinary approach was employed to develop and characterize bioactive liposomes incorporating resveratrol (RV), a polyphenol with known therapeutic potential but limited bioavailability, and <em>Thymus vulgaris</em> essential oil (TEO), recognized for its antimicrobial and antioxidant properties. To obtain stable nanocarriers, liposomes were formulated using soy lecithin and prepared by thin layer evaporation technique followed by sonication process. To assess the preservation of TEO's chemical profile during formulation, Headspace Solid Phase Microextraction coupled with Gas Chromatography–Mass Spectrometry (HS-SPME/GC-MS) was performed. Quantitative analysis of thymol and carvacrol, the two main active components, was performed by HPLC-UV experiments. Physicochemical characterization of DDS was carried out employing Dynamic Light Scattering (DLS), UV–Vis spectrophotometer and Transmission electron microscopy. Antimicrobial activity was assessed by broth microdilution method, while biofilm inhibition ability was evaluated using crystal violet staining. The obtained nanocarriers exhibited appropriate physicochemical characteristics, including optimal particle size and stability. They can efficiently load both oil and RV. These features enhanced the antibacterial activity of LT-RV compared to free RV, and improved its inhibitory effect, at sub-MIC concentrations, against the sessile form of <em>Listeria monocytogenes</em> strains.</div><div>This study highlights the importance of integrating chemical, physical, and biological evaluations to develop effective nanocarrier-based formulations with the aim to identify a suitable strategy to combat infections associated with resistant, biofilm-producing pathogens, and offer a versatile and effective delivery platform.</div></div>","PeriodicalId":15600,"journal":{"name":"Journal of Drug Delivery Science and Technology","volume":"117 ","pages":"Article 108027"},"PeriodicalIF":4.9,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146035414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Emerging therapies for lung adenocarcinoma: Mechanistic and efficacy insights from spheroid-based in vitro models","authors":"Pooja Sawant ,&nbsp;Ratnesh Jain ,&nbsp;Prajakta Dandekar","doi":"10.1016/j.jddst.2026.108030","DOIUrl":"10.1016/j.jddst.2026.108030","url":null,"abstract":"<div><div>The persistent challenges of drug resistance, tumor heterogeneity, and poor predictability of traditional 2D and animal models underscore the urgent need for innovative strategies in development of safe and efficacious anti-cancer interventions. In recent years, novel drug delivery systems (NDDS) such as nanoparticles, liposomes, antibody-drug conjugates, as well as inhalable formulations have emerged as promising approaches to enhance drug targeting, efficacy, and safety, particularly in hard-to-treat malignancies like lung cancer. Concurrently, 3D <em>in vitro</em> tumor spheroid models have gained recognition for their ability to recapitulate key features of the tumor microenvironment, including cell-cell and cell-matrix interactions, oxygen gradients, and drug penetration barriers. This manuscript presents a comprehensive compilation of the NDDS that have been evaluated using spheroid models and demonstrated substantial therapeutic potential, with many demonstrating translational success in subsequent animal studies. By highlighting the correlation between spheroid-based screening outcomes and <em>in vivo</em> efficacy, we aim to highlight the importance of spheroid models as efficient, reproducible, and ethically favorable tools for early-phase drug evaluation. Overall, this review emphasizes the dual relevance of NDDS and <em>in vitro</em> spheroid systems in advancing precision oncology while promoting the reduction of animal usage in research.</div></div>","PeriodicalId":15600,"journal":{"name":"Journal of Drug Delivery Science and Technology","volume":"117 ","pages":"Article 108030"},"PeriodicalIF":4.9,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146035338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pickering emulsions stabilized by pumpkin seed protein isolate/λ-carrageenan and their transdermal delivery performance","authors":"Danni Yan,&nbsp;Yining Xi,&nbsp;Xiangyun Cheng,&nbsp;Yihan Guo,&nbsp;Yunxing Li,&nbsp;Cheng Yang,&nbsp;Yajuan Sun","doi":"10.1016/j.jddst.2026.108057","DOIUrl":"10.1016/j.jddst.2026.108057","url":null,"abstract":"<div><div>Natural particle-stabilized Pickering emulsions have become prospective delivery vehicles in transdermal drug delivery due to their eco-friendliness, biocompatibility and minimal skin irritation. Herein, the transdermal delivery performance of oil-in-water Pickering emulsions stabilized by pumpkin seed protein isolate (PSPI)/λ-carrageenan (λCG) was investigated. λCG was found to improve the behavior of PSPI particles at the oil/water interface by increasing surface charge density and interacting with PSPI, thus optimizing the emulsifying property of PSPI and enhancing its protection performance on active substances. <em>In vitro</em> skin permeation studies demonstrated that λCG significantly promoted the transdermal delivery efficiency of PSPI-stabilized Pickering emulsions. Specifically, the 2.0 % λCG group yielded a 118.18 % increase in cumulated α-bisabolol in stratum corneum layer, a 52.59 % increase in the cumulated amount in the viable epidermis and dermis layer, 130.37 % increase in the subcutaneous layer, and an overall 96.23 % increase in total cumulated skin permeation compared to the pure PSPI group. Attenuated total reflection Fourier transform infrared spectroscopy further demonstrated that λCG modulated the lipid structure of porcine stratum corneum, contributing to its permeation enhancement mechanism. The formulation proposed in this study may serve as a promising drug carrier system in the field of transdermal administration.</div></div>","PeriodicalId":15600,"journal":{"name":"Journal of Drug Delivery Science and Technology","volume":"117 ","pages":"Article 108057"},"PeriodicalIF":4.9,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146074421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}