Journal of Drug Delivery Science and Technology最新文献

{"title":"Thermo-sensitive polyethylene glycol-based hydrogel for controlled peptide decoy release: a novel therapy for bladder fibrosis in male mice with partial outlet obstruction","authors":"Syuan-Hao Syu ,&nbsp;Chao-Yuan Chang ,&nbsp;Pu-Sheng Wei ,&nbsp;Van Long Le ,&nbsp;Yu-Ching Wen ,&nbsp;Hao-Jen Hsu ,&nbsp;Hung-Jen Shih ,&nbsp;Chun-Jen Huang","doi":"10.1016/j.jddst.2025.107533","DOIUrl":"10.1016/j.jddst.2025.107533","url":null,"abstract":"<div><div>A novel thermo-sensitive polyethylene glycol (PEG)-based hydrogel formulation combining KCF18—a peptide decoy that inhibits receptor binding of tumor necrosis factor-α, interleukin-1β, and interleukin-6—was developed to enable controlled release of KCF18 for the treatment of bladder fibrosis resulting from partial bladder outlet obstruction (BOO). The hydrogel, composed of methyl PEG–poly(lactic-co-glycolic acid) (mPEG–PLGA, diblock copolymer) and PLGA–PEG–PLGA (triblock copolymer) at a 5:5 wt ratio, was mixed with KCF18 (1.5 mg/kg) to produce a 20 % KCF-hydrogel solution (100 μL). Pharmacokinetic analysis revealed a peak plasma KCF18 concentration on Day 1, sustained through Day 2, with an estimated half-life of 3.5 days. In an adult male mouse model of BOO-induced bladder fibrosis, weekly subcutaneous administration of the KCF-hydrogel for seven weeks improved bladder function, reduced fibrosis, and downregulated transforming growth factor-β and fibrosis-related markers, including collagen I, vimentin, and α-smooth muscle actin. Therapeutic benefits were observed when treatment was initiated during the early or mid-disease stages (Day 7 or 14 post-BOO), but not in the late stage (Day 28). This thermo-sensitive PEG-based hydrogel enables controlled KCF18 release, offering a promising therapeutic strategy for BOO-induced bladder fibrosis when administered in the early or mid-disease stages.</div></div>","PeriodicalId":15600,"journal":{"name":"Journal of Drug Delivery Science and Technology","volume":"114 ","pages":"Article 107533"},"PeriodicalIF":4.9,"publicationDate":"2025-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145060246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sildenafil-chitosan nanocomplexes in rosemary-infused smart emulgel: Sustainable drug delivery with improved hair regeneration efficacy","authors":"Amr Maged ,&nbsp;Rabab Kamel ,&nbsp;Azza A. Mahmoud ,&nbsp;Yasmin A. Elkhawas ,&nbsp;Shimaa K. Mohamed ,&nbsp;Noha Khalil","doi":"10.1016/j.jddst.2025.107502","DOIUrl":"10.1016/j.jddst.2025.107502","url":null,"abstract":"<div><div>Hair loss, a prevalent dermatological condition with profound psychosocial impacts, arises from genetic, hormonal, environmental, and pathological factors. This study developed sildenafil-loaded chitosan nanocomplexes using varying molar ratios (1:2, 1:1, 2:1) of chitosan HCl (CHC) and carboxymethyl chitosan (CMCH) at concentrations of 2, 4, and 6 mM. The nanocomplexes were characterized for particle size, polydispersity index (PDI), zeta potential, drug loading, and <em>in-vitro</em> drug release. The optimal nanocomplex (C5) composed of 1:1 CHC:CMCH (4 mM) exhibited a particle size of 218.9 nm, PDI of 0.1, zeta potential of +20.2 mV, and drug loading of 65.8 %, with a sustained drug release (T50 = 12.1 h; T90 = 38.5 h). A smart thermosensitive emulgel, which remained liquid at room temperature and gelled at scalp temperature, was prepared using poloxamer 407 (14.5 % w/v) and poloxamer 188 (5.5 % w/v) (total poloxamer: 20 % w/v) and 10 % w/v rosemary oil which was phytochemically characterized by GC/MS analysis. The major constituents identified in the oil were camphor (17.82 ± 1.98 %), 1,8-cineole (12.56 ± 2.14 %), and borneol (10.01 ± 1.44 %). The selected nanocomplex (C5) was incorporated into the emulgel and evaluated for hair growth in C57BL/6 mice over 12 days, compared to minoxidil market product. The selected C5-loaded emulgel demonstrated comparable efficacy to the market product containing minoxidil, with superior hair regeneration, significant upregulation of p-PI3K and VEGF, and marked downregulation of TGF-β. This study presents an innovative, aesthetically acceptable topical sildenafil formulation that leverages chitosan nanocomplexes and rosemary oil to enhance follicular delivery and prolong therapeutic action. This approach offers a promising non-invasive alternative for alopecia therapy.</div></div>","PeriodicalId":15600,"journal":{"name":"Journal of Drug Delivery Science and Technology","volume":"114 ","pages":"Article 107502"},"PeriodicalIF":4.9,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145096017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Wound healing management using microneedle array patch: Journey so far and road ahead","authors":"Sriya Panda ,&nbsp;Siddhi Pashankar ,&nbsp;Saniya Rajput ,&nbsp;Rachana Ghewari ,&nbsp;Akhilesh Vardikar ,&nbsp;Kaustubh Ajit Kolekar ,&nbsp;Sachin Kumar Singh ,&nbsp;Shweta Inamdar ,&nbsp;Kalyani Duparte ,&nbsp;S. Hari Rajan ,&nbsp;Amarjitsing Rajput","doi":"10.1016/j.jddst.2025.107522","DOIUrl":"10.1016/j.jddst.2025.107522","url":null,"abstract":"<div><div>Microneedles have emerged as a cutting-edge platform in wound management, offering minimally invasive approaches for localized therapy and tissue regeneration. The solid, hollow, dissolving, and coated microneedle systems are all thoroughly covered in this review. It is also discuss and examine how structural parameters such as length, geometry, material choice that influence therapeutic efficiency and patient comfort. Microneedles applications in diabetic ulcers, surgical wounds, burn injuries, infected wounds, and scarless wound healing highlight their ability to accelerate tissue repair, minimize complications, and improve patient outcomes. The novelty of this review lies in integrating advances in material design with emerging smart functionalities, including biosensing-enabled microneedles and combinatorial strategies with growth factors, antimicrobials, and nanomaterials. These approaches demonstrate the potential to transform wound care from passive protection to actively guided therapy. Despite notable progress, several knowledge gaps remain. Current systems face limitations in drug-loading capacity, variability in mechanical strength, and challenges in balancing biodegradability with sustained functionality. Moreover, regulatory and translational barriers continue to slow clinical adoption. Addressing these gaps requires not only optimization of fabrication technologies such as additive manufacturing but also rigorous evaluation of biocompatibility, safety, and long-term performance. Looking ahead, future directions emphasize the development of multifunctional microneedles capable of real-time wound monitoring, environment-responsive drug release, and integration with digital health platforms. Such innovations represent promising next-generation strategies to achieve precision, adaptability, and scalability in modern wound therapy.</div></div>","PeriodicalId":15600,"journal":{"name":"Journal of Drug Delivery Science and Technology","volume":"114 ","pages":"Article 107522"},"PeriodicalIF":4.9,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145096010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dual-crosslinked injectable in situ forming Alginate/CaCl2/Pluronic F127/α-Cyclodextrin hydrogels incorporating Doxorubicin and graphene-based nanomaterials for cancer chemo-photothermal therapy","authors":"Joaquim J. Gonçalves ,&nbsp;Bruna L. Melo ,&nbsp;Manuel R. Pouso ,&nbsp;Ilídio J. Correia ,&nbsp;Duarte de Melo-Diogo","doi":"10.1016/j.jddst.2025.107520","DOIUrl":"10.1016/j.jddst.2025.107520","url":null,"abstract":"<div><div>Injectable <em>in situ</em> forming hydrogels have been emerging due to their capacity to perform the direct delivery of therapeutics into the tumor site with minimal off-target leakage. Particularly, physical crosslinked injectable <em>in situ</em> forming hydrogels are appealing due to their straightforward preparation that exploits the native jointing capabilities of specific polymers/materials. However, the features of these hydrogels (<em>e.g.</em>, injectability, degradation, swelling) are strongly pre-determined by the physical interactions available on the selected polymers/materials, occasionally yielding undesired outcomes. Thus, the combination of multiple physical crosslinking cues may allow the preparation of hydrogels with enhanced properties. In this work, a dual-crosslinked injectable <em>in situ</em> forming hydrogel was engineered by combining Pluronic F127/α-Cyclodextrin and Alginate/CaCl₂ (<em>i.e.</em>, combination of host-guest and electrostatic interactions), being loaded with Doxorubicin (chemotherapeutic drug) and Dopamine-reduced Graphene Oxide (photothermal nano-agent) for application in cancer chemo-photothermal therapy. When compared to the single-crosslinked hydrogels, the dual-crosslinking contributed to the assembly of formulations with suitable injectability and improved degradation and water absorption behaviors. Moreover, the dual-crosslinked hydrogels presented a good photothermal capacity (ΔT ≈ 14 °C), leading to a 1.18-times enhanced Doxorubicin release. In <em>in vitro</em> cell-based studies, the dual-crosslinked hydrogels exhibited an excellent cytocompatibility towards healthy (normal human dermal fibroblasts) and breast cancer (MCF-7) cells. As importantly, the dual-crosslinked hydrogels were able to mediate a chemo-photothermal effect that diminished the cancer cells’ viability to just 23 %. Overall, the developed dual-crosslinked injectable <em>in situ</em> forming hydrogels incorporating Doxorubicin and Dopamine-reduced Graphene Oxide are a promising macroscale system for breast cancer chemo-photothermal therapy.</div></div>","PeriodicalId":15600,"journal":{"name":"Journal of Drug Delivery Science and Technology","volume":"114 ","pages":"Article 107520"},"PeriodicalIF":4.9,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145060221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Poly-l-arginine grafted PAMAM dendrimers for the brain delivery of Temozolomide in the management of Glioblastoma multiforme: In-vitro and In-vivo evaluation","authors":"Rakesh Kumar Sahoo ,&nbsp;Kushagra Nagori ,&nbsp;Ajazuddin ,&nbsp;Biswajit Naik ,&nbsp;Dhaneswar Prusty ,&nbsp;Rishi Paliwal ,&nbsp;Umesh Gupta","doi":"10.1016/j.jddst.2025.107526","DOIUrl":"10.1016/j.jddst.2025.107526","url":null,"abstract":"<div><h3>Purpose</h3><div>Glioblastoma multiforme (GBM) is one of the most aggressive and pervasive forms of malignant primary brain tumor. The objective is to develop an energy and receptor independent nanocarrier for the management of GBM.</div></div><div><h3>Methods</h3><div>In the present work, pArg was conjugated on to the surface of PAMAM dendrimers as per the findings of <em>in-silico</em> molecular docking study, followed by TMZ encapsulation. Den-pArg conjugate was synthesized at 1:8 ratio as per binding affinity analysis and successfully characterized by ¹H NMR.</div></div><div><h3>Results</h3><div>The average particle size and entrapment efficiency of TMZ@Den-pArg were 198.72 ± 14.96 nm and 72.12 ± 5.81 %, respectively. TMZ@Den-pArg was biocompatible and showed sustained and controlled drug release up to 48 h in acidic environment. TMZ@Den-pArg resulted in maximum cytotoxic effect against both U87MG and LN229 cells. In comparison to pure TMZ, plasma half-life (t_1/2) of TMZ@Den-pArg (7.04 ± 0.81 h) was enhanced by almost 3 times in healthy rats. After 4 h of administration, the TMZ@Den-pArg resulted in significantly (p &lt; 0.0001) higher accumulation in cerebrum (28.51 ± 2.12 ng per g of brain) than cerebellum. Den-pArg reduced the drug distribution to heart and kidney.</div></div><div><h3>Conclusions</h3><div>The findings suggested that polyarginine conjugated PAMAM dendrimers can be a potential nanocarrier for the brain delivery of chemotherapeutic agents.</div></div>","PeriodicalId":15600,"journal":{"name":"Journal of Drug Delivery Science and Technology","volume":"114 ","pages":"Article 107526"},"PeriodicalIF":4.9,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145096012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Formulation screening for local delivery of mRNA and photosensitizer to treat superficial tumor","authors":"Lei huang ,&nbsp;Siyuan Tang ,&nbsp;Jiachen Guo ,&nbsp;Yixing Tu ,&nbsp;Sian Li ,&nbsp;Taihua Yang ,&nbsp;Dong Zhao ,&nbsp;Chao Wang","doi":"10.1016/j.jddst.2025.107525","DOIUrl":"10.1016/j.jddst.2025.107525","url":null,"abstract":"<div><div>Localized delivery of mRNA-based therapies has shown promise in cancer treatment, but challenges such as drug leakage and systemic toxicity remain. This study aimed to develop a locally retained lipid nanoparticle (LNP) system for the co-delivery of mRNA and the photosensitizer indocyanine green (ICG) to treat superficial tumors. By systematically optimizing the lipid composition and mRNA-to-ICG ratio, we achieved high encapsulation efficiency and localized protein expression. The LNP system demonstrated robust transfection efficiency and photothermal effects, with minimal off-target distribution. In vivo studies revealed significant tumor growth inhibition, highlighting the potential of this approach for localized cancer therapy. This study provides a novel strategy for the co-delivery of mRNA and photosensitizers, offering a promising avenue for the treatment of superficial tumors with minimal systemic exposure.</div></div>","PeriodicalId":15600,"journal":{"name":"Journal of Drug Delivery Science and Technology","volume":"114 ","pages":"Article 107525"},"PeriodicalIF":4.9,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145060220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cholecalciferol-grafted hollow mesoporous silica nanoparticles for targeted and sustained caffeine delivery in alopecia therapy","authors":"Nattanida Thepphankulngarm ,&nbsp;Nutchalin Isariyavuth ,&nbsp;Chomploy Renumas ,&nbsp;Jarupha Meeyim ,&nbsp;Suwisit manmuan ,&nbsp;Namon Hirun ,&nbsp;Pakorn Kraisit","doi":"10.1016/j.jddst.2025.107518","DOIUrl":"10.1016/j.jddst.2025.107518","url":null,"abstract":"<div><div>Alopecia is a common and often distressing condition marked by progressive hair loss and follicular damage. While finasteride and minoxidil (MNX) remain standard treatments for alopecia, their adverse systemic effects drive the need for safer alternatives. Caffeine (Caf), a natural stimulant with hair growth–promoting properties, is limited by its hydrophilicity and poor follicular retention. To address these limitations, we developed hollow mesoporous silica nanoparticles (HMSNs) grafted with cholecalciferol (VitD-HMSNs) to improve targeted delivery and sustained release of Caf. The high lipophilicity of cholecalciferol enhances follicular permeation, and its antioxidant and anti-inflammatory effects may act synergistically with Caf to promote localized hair-regrowth while reducing systemic exposure. HMSNs were synthesized via Sol-Gel and Template-Assisted methods, followed by selective etching. The nanoparticles showed suitable physicochemical properties for transdermal delivery, including an average particle size of ∼150 nm, a pore size of 2.8 nm, and a specific surface area of 1095 m²/g. Fourier-transform infrared (FT-IR) spectroscopy confirmed successful cholecalciferol grafting. Caf was efficiently loaded (% encapsulation efficiency, 32.11 %; % loading capacity, 24.31 %), and <em>in vitro</em> release demonstrated a more sustained profile for caffeine-loaded hollow mesoporous silica nanoparticles grafted with cholecalciferol (VitD-Caf@HMSNs) than for ungrafted HMSNs. Franz diffusion studies showed enhanced skin permeation with VitD-Caf@HMSNs (476.63 μg/cm²). Confocal laser scanning microscopy (CLSM) imaging confirmed deeper nanoparticle penetration—up to 280 μm into porcine skin—along with accumulation around hair follicles, supporting the system's targeting potential. In human hair follicle dermal papilla cells (HFDPCs), MTT assays confirmed the biocompatibility of VitD-Caf@HMSNs. In dihydrotestosterone (DHT)-challenged cells, VitD-Caf@HMSNs markedly reduced reactive oxygen species (ROS), achieving antioxidant activity comparable to that of MNX. In summary, these findings indicate that VitD-Caf@HMSNs are a receptor-targeted, biocompatible nanocarrier that enables sustained, localized Caf delivery for alopecia therapy, potentially offering a minimally invasive alternative to conventional treatments.</div></div>","PeriodicalId":15600,"journal":{"name":"Journal of Drug Delivery Science and Technology","volume":"114 ","pages":"Article 107518"},"PeriodicalIF":4.9,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145045376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advances in stimuli-responsive nanoparticles for cancer therapy: Mechanisms, functional materials, and emerging technologies","authors":"Alan Clavelland Ochioni ,&nbsp;Italo Rennan Sousa Vieira ,&nbsp;Carlos Adam Conte-Junior","doi":"10.1016/j.jddst.2025.107519","DOIUrl":"10.1016/j.jddst.2025.107519","url":null,"abstract":"<div><div>Cancer is a multifactorial disease and hence demands different therapeutic strategies to arrest its progression and recurrence. Conventional therapies such as chemotherapy and radiotherapy, while widely used, present limitations, including low specificity, systemic toxicity, and drug resistance. In this context, nanotechnology has emerged as a promising non-invasive approach, offering enhanced targeting, controlled drug release, and reduced side effects. This critical review integrates the latest advancements in stimuli-responsive smart nanoparticles, including polymeric, lipid-based, and inorganic nanocarriers, while emphasizing both their mechanistic aspects and translational challenges. Special emphasis is given to exogenous and endogenous stimuli-responsive nanoparticles, such as pH, redox, enzyme, and magnetic field-responsive nanomaterials, which enable site-specific drug activation and minimize off-target effects. Furthermore, we discuss cutting-edge technologies, including CRISPR-Cas9-loaded nanoparticles for gene silencing, AI-driven nanoparticle modeling for precision medicine, biomimetic nanoparticles for enhanced biocompatibility, and liquid biopsy-integrated nanodiagnostics for early cancer detection. The diversity of nanomaterials and their action in different classes is evaluated to improve cancer treatment by using a range of therapeutic agents. Despite their potential, our analysis highlights several challenges for the clinical application of nanoparticle-based delivery systems, including stability, toxicity, long-term safety, and regulatory aspects. This comprehensive and integrative approach provides new insights to guide future research and clinical translation of smart nanomedicine in oncology.</div></div>","PeriodicalId":15600,"journal":{"name":"Journal of Drug Delivery Science and Technology","volume":"114 ","pages":"Article 107519"},"PeriodicalIF":4.9,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145060212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Celecoxib-loaded mesenchymal stem cell-derived exosomes ameliorate laser-induced choroidal neovascularization in a rabbit model","authors":"Shahla Lotfi ,&nbsp;Pasha Anvari ,&nbsp;Aghdas Ramezani ,&nbsp;Pegah Kazemi ,&nbsp;Davoud Ahmadvand","doi":"10.1016/j.jddst.2025.107514","DOIUrl":"10.1016/j.jddst.2025.107514","url":null,"abstract":"<div><div>Neovascular age-related macular degeneration (nAMD), cause of central vision blindness, is associated with choroidal neovascularization (CNV). The objective of this research was to assess the treatment capabilities of Celecoxib-loaded exosomes, and directly compare their efficacy with three other approaches, free Celecoxib, pure exosomes, and Bevacizumab, in a laser-induced CNV rabbit model. Human umbilical cord mesenchymal stem cells (hUC-MSCs) derived exosomes were isolated by ultracentrifugation and identified means of dynamic light scattering, field emission scanning electron microscopy, and flow cytometry. Celecoxib was loaded into exosomes through passive incubation. Eighteen rabbits were divided into six groups: a healthy control group, an untreated CNV group, and four treatment groups. CNV was induced by thermal laser photocoagulation. Therapeutic effects were examined via fluorescein angiography (FA), optical coherence tomography (OCT), and histopathological analysis. The exosomes showed successful structural and surface marker profiles, and Celecoxib was effectively loaded with an efficiency of 18.08 ± 0.21 %. All treatment groups exhibited significant reductions (p &lt; 0.0001) in CNV area and vascular leakage relative to the untreated control. The group receiving Celecoxib-loaded exosome showed the most substantial improvement in imaging outcomes, reducing CNV thickness by 60.43 % and fluorescein leakage by 75.95 % in OCT and FA analyses, respectively. Histopathological evaluation further confirmed therapeutic efficacy, showing a 72.79 % reduction in CNV thickness. Delivering Celecoxib via exosomes markedly enhanced its therapeutic performance in CNV. This combined strategy leverages the anti-inflammatory and anti-angiogenic capabilities of Celecoxib with the regenerative capacity and targeted delivery advantages of exosomes, offering a promising direction for future treatments of nAMD.</div></div>","PeriodicalId":15600,"journal":{"name":"Journal of Drug Delivery Science and Technology","volume":"114 ","pages":"Article 107514"},"PeriodicalIF":4.9,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145060163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of a jackfruit latex-based mucoadhesive biomaterial incorporated with pomegranate (Punica granatum L.) extract for periodontitis treatment","authors":"Barbara B.T. de Lima ,&nbsp;Bruna V. Quevedo ,&nbsp;Kaique G. Hergesel ,&nbsp;Daniel Komatsu ,&nbsp;Eliana Aparecida de Rezende Duek","doi":"10.1016/j.jddst.2025.107524","DOIUrl":"10.1016/j.jddst.2025.107524","url":null,"abstract":"<div><div>Periodontitis is a chronic inflammatory disease that affects the supporting structures of the teeth, resulting in the destruction of bone and periodontal ligaments. Pathogenic bacterial biofilms play a central role in initiating and sustaining the inflammatory response. Conventional treatments, such as mechanical biofilm removal and antibiotic therapy, have limitations, including antimicrobial resistance and undesirable side effects. Mucoadhesive biomaterials and antimicrobial phytotherapeutics have emerged as promising therapeutic strategies. This study aimed to develop and characterize a mucoadhesive biomaterial based on jackfruit latex (JL) (<em>Artocarpus heterophyllus</em>), incorporating different concentrations (2.5 %, 5.0 %, and 10.0 %) of pomegranate peel extract (PPE) (<em>Punica granatum</em> L.), and to evaluate its physicochemical and antimicrobial properties. JL is a natural, highly adhesive, sustainable, and cost-effective polymeric gum, while PPE is known for its antimicrobial and anti-inflammatory properties. FTIR analysis revealed physical interactions between JL and PPE. Thermal analysis demonstrated that the developed materials exhibit thermal stability. The JL+5 %PPE formulation showed optimized performance in the sustained <em>in vitro</em> release of PPE over a period of 840 h. Antimicrobial assays indicated that PPE effectively inhibits the growth of both Gram-positive bacteria (<em>Staphylococcus aureus</em> and <em>Streptococcus oralis</em>) and Gram-negative bacteria (<em>Escherichia coli</em>). Moreover, SEM analysis revealed that the JL+5 %PPE formulation was capable of inhibiting bacterial biofilm formation. The mucoadhesive capacity was confirmed through compression tests using mucin discs. Furthermore, the samples exhibited cell viability greater than 100 % after 24 h of culture. The results reinforce the potential of JL incorporated into PPE as an alternative for the treatment of periodontitis.</div></div>","PeriodicalId":15600,"journal":{"name":"Journal of Drug Delivery Science and Technology","volume":"114 ","pages":"Article 107524"},"PeriodicalIF":4.9,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145060219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}