Journal of Drug Delivery Science and Technology最新文献

{"title":"Retraction notice to “Trilazad mesylate-loaded electrospun cellulose acetate nanofibrous wound dressings promote diabetic wound healing by modulation of immune response and protection against oxidative damage” [J. Drug Deliv. Sci. Technol. 69 (2021) 102863]","authors":"Lei Lei , Weihong Huang , Ke Liu , Xiaobo Liu , Mingbin Dai , Zhichuan Liu , Yongjian Zhiao","doi":"10.1016/j.jddst.2025.107035","DOIUrl":"10.1016/j.jddst.2025.107035","url":null,"abstract":"","PeriodicalId":15600,"journal":{"name":"Journal of Drug Delivery Science and Technology","volume":"110 ","pages":"Article 107035"},"PeriodicalIF":4.5,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144242409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multifunctional NiO-curcumin nanocomposite-loaded chitosan-alginate scaffolds for enhanced bone tissue regeneration and antibacterial activity","authors":"Logesh Kumar Sellappan ,&nbsp;Shivam Mishra ,&nbsp;Sruthi Sundaresan ,&nbsp;Thenmalarchelvi Rathinavelan ,&nbsp;Saptarshi Majumdar","doi":"10.1016/j.jddst.2025.107114","DOIUrl":"10.1016/j.jddst.2025.107114","url":null,"abstract":"<div><div>Regenerating infected bone tissue requires advanced biomaterials that integrate mechanical strength, antibacterial properties, and biomineralization potential. Here, we developed bioactive chitosan-alginate (CA) scaffolds reinforced with nickel oxide-curcumin (NiO-Cur) nanocomposites (CANC) using sol-gel synthesis, chemical crosslinking, and freeze-drying. The incorporation of NiO-Cur nanocomposites enhanced the scaffolds structural and functional properties, as confirmed by ATR-FTIR, XRD, FE-SEM, and EDAX analyses. The scaffolds exhibited better compressive strength (406.1 ± 3.79 KPa), high porosity (85.72 ± 1.01 % to 91.08 ± 1.19 %) with interconnected honeycomb-like pores (114–132 μm), facilitating nutrient diffusion and cellular infiltration. Enhanced compressive strength and rheological properties (G′ &gt; G′′) demonstrated their ability to dissipate shear stress and withstand dynamic loads, critical for bone tissue engineering. Cur release profiles for CANC1, CANC2, and CANC3 scaffolds after 72 h were 72.05 %, 78.32 %, and 83.95 %, respectively. Additionally, CANC scaffolds also displayed superior hydrophilicity, promoting swelling and controlled degradation under physiological conditions. <em>In vitro</em> biomineralization studies revealed dense apatite formation within 14 days in simulated body fluid, favouring osteoconductive potential. Additionally, CANC scaffolds exhibited significant antibacterial activity with zone of inhibition value of (10.78 ± 0.23 mm) against <em>Staphylococcus aureus</em> and (8.05 ± 0.2 mm) <em>Escherichia coli</em>, suggesting efficacy in preventing post-surgical infections. The synergistic interaction between NiO-Cur nanocomposites and the CA matrix improved physicochemical, mechanical, and rheological stability, alongside enhanced antibacterial efficacy and apatite-forming potential. Preclinical studies could further validate the potential of CANC scaffolds to accelerate bone healing, reduce recovery time in infected bone injuries, and advance tissue regeneration applications.</div></div>","PeriodicalId":15600,"journal":{"name":"Journal of Drug Delivery Science and Technology","volume":"110 ","pages":"Article 107114"},"PeriodicalIF":4.5,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144204179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Non-invasive fast-acting lidocaine HCl lozenges for ventricular Arrhythmia: Formulation, optimization, and in vivo pharmacodynamic study","authors":"Hetal P. Patel ,&nbsp;Aashka H. Bhatt ,&nbsp;Pruthil A. Tejani ,&nbsp;Priyanshi R. Patel ,&nbsp;Rutvi J. Vaidya ,&nbsp;Bhavin A. Vyas ,&nbsp;Furqan A. Maulvi","doi":"10.1016/j.jddst.2025.107113","DOIUrl":"10.1016/j.jddst.2025.107113","url":null,"abstract":"<div><div>Ventricular arrhythmia is a severe, life-threatening condition that demands immediate medical intervention. Intravenous (IV) lidocaine hydrochloride (HCl) is widely used for emergency management; however, its invasive administration and requirement for medical supervision limit its practicality. While oral administration is a more patient-friendly alternative, lidocaine HCl exhibits only 35 % oral bioavailability due to extensive hepatic first-pass metabolism, leading to inconsistent systemic drug levels. This study aimed to develop lidocaine HCl hard candy lozenges as a non-invasive, fast-acting alternative that leverages oral mucosal absorption to enhance bioavailability and accelerate onset of action. A Central Composite Design (CCD) was employed to optimize the formulation by evaluating the effects of sucrose (X₁) and HPMC E5 (X₂) on drug release (Y₁) and mouth dissolving time (Y₂). Lozenges were prepared using the heating and congealing technique and were assessed for physical properties, in vitro drug release, and <em>in vivo</em> pharmacodynamics. The optimized formulation demonstrated uniform shape, smooth texture, and high mechanical strength, ensuring ease of handling and patient acceptability. It achieved 97.31 % lidocaine HCl release within 5 min and a mouth dissolution time of 11.27 min, confirming rapid systemic availability. Pharmacodynamic evaluation using a calcium chloride-induced ventricular arrhythmia rat model revealed a significant reduction in arrhythmic episodes, with normalization of cardiac electrical activity within 10 min of administration. The rapid therapeutic response was attributed to the formulation's fast dissolution and efficient mucosal absorption, which bypass first-pass metabolism and mimics the rapid action of IV lidocaine HCl. Thus, lidocaine HCl hard candy lozenges provide a novel, non-invasive alternative for ventricular arrhythmia management, overcoming the limitations of injectable formulations while ensuring patient compliance. Future studies should focus on clinical validation, long-term stability, and expanding applications in emergency cardiac care.</div></div>","PeriodicalId":15600,"journal":{"name":"Journal of Drug Delivery Science and Technology","volume":"110 ","pages":"Article 107113"},"PeriodicalIF":4.5,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144169332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring roflumilast transferosomes in pluronic-hyaluronic acid hydrogel through comprehensive in-vitro and in-vivo evaluation","authors":"Ahmed Abdelaziz ,&nbsp;Mariam Zewail ,&nbsp;Haidy Abbas ,&nbsp;Maged W. Helmy ,&nbsp;Doaa A. Habib","doi":"10.1016/j.jddst.2025.107081","DOIUrl":"10.1016/j.jddst.2025.107081","url":null,"abstract":"<div><div>Roflumilast (RF) is a phosphodiesterase-4 inhibitor that has been recently approved to treat psoriasis. This study aims to enhance the topical anti-psoriasis pharmacological effect of RF through the preparation of RF-loaded transferosomes (TRFs) and loading them in a poloxamer-hyaluronic acid hydrogel. TRF were prepared through the ethanol injection technique in which different ratios of lipid: surfactant was examined to determine the optimum formula. F4 and F12 with two different drug concentrations (0.1 % and 0.2 %) were found to be the most optimized formulations according to the <em>in-vitro</em> characterizations. These formulations had the highest percentage of drug release after 24 h (102.74 % and 106.95 %, respectively), high EE % (81.9 % and 91.2 %, respectively), and small vesicle size (101.4 nm and 218.5 nm, respectively). F4 and F12 were then incorporated into poloxamer-hyaluronic acid hydrogel followed by further in-vivo examination. <em>In vivo</em> pharmacological study assessed the possible positive impact of RF-TRF Hydrogel in treating psoriasis by utilizing an Imiquimod (IMQ)-induced psoriasis-like mouse model. Psoriasis Area Severity Index <em>(</em>PASI) was employed to assess the inflammation severity on the backs of mice concerning erythema, thickness, and scaling scoring. Histopathological examination to evaluate epidermal thickness and immunohistochemical analysis to determine proliferating cell nuclear antigen (PCNA) expression in mice's lesional skin also were employed. Our findings indicated that RF-TRF hydrogel effectively decreased the PASI scores. Histopathological examination showed a significant decrease in epidermal thickness. Additionally, RF-TRF hydrogel successfully reduced the expression of PCNA in the skin lesions caused by IMQ in mice. In conclusion, our work showed that RF-TRF hydrogel showed significant enhancement of the anti-psoriasis effect.</div></div>","PeriodicalId":15600,"journal":{"name":"Journal of Drug Delivery Science and Technology","volume":"110 ","pages":"Article 107081"},"PeriodicalIF":4.5,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144168839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acalabrutinib loaded nanostructured lipid carriers to improve the oral delivery of the drug: Optimization, physicochemical characterization, in vivo pharmacokinetics and lymphatic uptake studies","authors":"Swagata Sinha,&nbsp;Punna Rao Ravi,&nbsp;Kotgire Prathmesh,&nbsp;Barun Ghosh","doi":"10.1016/j.jddst.2025.107100","DOIUrl":"10.1016/j.jddst.2025.107100","url":null,"abstract":"<div><div>Nanostructured lipid carriers (NLCs) offer a promising solution for improving the delivery of lipophilic drugs by enhancing solubility, bioavailability, and targeting, though optimizing their physicochemical properties, such as particle size and drug loading, remains challenging. Traditional one-factor-at-a-time methods fail to account for complex interactions among variables, so this study employs a design of experiments approach to optimize NLCs for oral delivery of acalabrutinib, using a 2⁵⁻¹ fractional factorial design for screening followed by a circumscribed central composite design for optimization. The optimized NLCs exhibited spherical morphology with a mean particle size of 249.3 ± 9.1 nm with PDI of 0.349 ± 0.036, 10.69 ± 0.51 % loading and 77.51 ± 3.72 % entrapment efficiency. The <em>in vitro</em> release of acalabrutinib from the NLCs followed square root kinetics with 100 % drug release at the end of 48 h in pH 7.2. The formulation exhibited stable particle size and entrapment efficiency with minimum deviations when stored at 5 °C for 6 months. Oral pharmacokinetic studies showed that NLCs nanosuspension enhanced C_max and AUC_0-tlast by 2.17- and 4.35-folds (p &lt; 0.001) compared to conventional suspension. Additionally, NLCs sustained plasma drug concentrations longer, with an MRT_0-tlast of 6.97 h vs. 3.61 ± 0.19 h for the conventional suspension. Inhibiting the lymphatic flow reduced the AUC_0-tlast by 44.14 %, highlighting the significant role played by lymphatic transport in the oral absorption NLCs. This study underscores the potential of the developed NLCs as an effective platform for oral delivery of acalabrutinib.</div></div>","PeriodicalId":15600,"journal":{"name":"Journal of Drug Delivery Science and Technology","volume":"110 ","pages":"Article 107100"},"PeriodicalIF":4.5,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144189994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thermo-engineered zinc-alginate and pectin stabilized hydroxyapatite microspheres: A synergistic approach for bone repair and drug delivery","authors":"Muthulakshmi Vaikundam ,&nbsp;Kumar Ponnuchamy ,&nbsp;Amutha Santhanam","doi":"10.1016/j.jddst.2025.107096","DOIUrl":"10.1016/j.jddst.2025.107096","url":null,"abstract":"<div><div>This study reports the development of thermally engineered Zn-alginate-pectin stabilized hydroxyapatite (pHAP) microsphere for enhanced bone repair and targeted drug delivery. The microspheres were synthesized via a green route using <em>carrot pomace</em>-derived pectin mediated HAP with alginate, offering a biocompatible and biodegradable platform that mimics bone mineral. Incorporation of Zn²⁺ through Zn(NO₃)₂ cross-linking improved osteo conductivity, while calcination at 1000 °C facilitated phase transformation and zinc substitution into the HAP lattice, enhancing structural integrity and bioactivity. <em>In vitro</em> studies using MG-63 cells confirmed improved cell proliferation, ALP activity, and biomineralization, supporting their role in bone repair. In parallel, the system served as an efficient drug delivery platform by separately loading doxorubicin (DOX) and methotrexate (MTX). Drug release studies for both the drugs revealed a sustained and pH-responsive profile, with faster release under acidic conditions mimicking the tumour microenvironment. Cytotoxicity assays on MCF-7 and A549 cancer cells demonstrated significant, dose-dependent antiproliferative effects, with DOX-loaded microspheres showing higher potency. Apoptotic analysis (AO/EB and Hoechst staining) and migration/invasion studies (Scratch and Trans well assays) confirmed enhanced cancer cell inhibition. This dual-functional microsphere combines structural support for bone regeneration with controlled, localized chemotherapeutic delivery. The outcome results of this study highlighted that the integration of thermal engineering with biopolymers and zinc doping presents a unique and effective strategy.</div></div>","PeriodicalId":15600,"journal":{"name":"Journal of Drug Delivery Science and Technology","volume":"110 ","pages":"Article 107096"},"PeriodicalIF":4.5,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144178773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mechano-chemically activated co-amorphous of oleanolic acid and sodium cholate: enhancement of solubility, dissolution and bioactivity against visceral pain in a rat model of colitis","authors":"Francesco Baldi ,&nbsp;Clara Ciampi ,&nbsp;Lorenzo Di Cesare Mannelli ,&nbsp;Muhammad Wasim ,&nbsp;Maria Cristina Salvatici ,&nbsp;Carla Ghelardini ,&nbsp;Anna Rita Bilia ,&nbsp;Maria Camilla Bergonzi","doi":"10.1016/j.jddst.2025.107110","DOIUrl":"10.1016/j.jddst.2025.107110","url":null,"abstract":"<div><div>This study aimed to enhance the solubility and bioavailability of oleanolic acid (OA), a highly insoluble compound, using a mechanochemical approach to form co-ground (COG) with sodium cholate (NaC). Through high-energy grinding in a ball mill, the binary COG was prepared, and then characterized and evaluated. The initial screening of ten hydrophilic carriers identified NaC as the most effective, forming a COG with OA in a 1:1 wt ratio after 30 min of grinding. Detailed characterizations, including DSC, FT-IR, XRPD, and SEM, identified the mechanisms behind the substantial solubility enhancement of OA, achieving up to 623 μg/mL, and confirmed the formation of the co-ground. The formation of a co-amorphous structure, and the establishment of intermolecular interactions between OA and NaC were identified as key factors contributing to this improvement. Dissolution tests revealed that COG achieved an 80 % dissolution rate of OA within 2 h, compared to just 30 % for pure OA, demonstrating the effectiveness of COG in maintaining high solubility and preventing recrystallization. <em>In vivo</em> tests on a rat model of DNBS-induced colitis showed promising results. The acute administration of COG significantly reduced visceral pain compared to unformulated OA, suggesting enhanced bioavailability and therapeutic efficacy. While pure OA 15 mg/kg is inactive, COG 30 mg/kg, composed of OA 15 mg/kg and NaC 15 mg/kg, displays a statistically significant pharmacological effect, with a percentage reduction in AUC equal to 40 %. This research highlights the potential of mechanochemical activation in developing effective OA formulations, offering a green chemistry solution that is efficient, solvent-free, and environmentally friendly. The study provides a solid foundation for further exploration of OA-based treatments for chronic inflammatory conditions and pain management.</div></div>","PeriodicalId":15600,"journal":{"name":"Journal of Drug Delivery Science and Technology","volume":"110 ","pages":"Article 107110"},"PeriodicalIF":4.5,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144169348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multifunctional hydrogel based on decellularized intestinal matrix, carboxymethyl cellulose and ciprofloxacin for accelerated wound healing","authors":"Mahsa Lotfi ,&nbsp;Bizhan Nomanpour ,&nbsp;Parvaneh Saffarian ,&nbsp;Kamran Mansouri","doi":"10.1016/j.jddst.2025.107109","DOIUrl":"10.1016/j.jddst.2025.107109","url":null,"abstract":"<div><div>Wound healing remains a critical challenge in both clinical practice and biomedical research. The preparation of a functional hydrogel can be an effective strategy for accelerating wound healing. In the present study, small intestinal submucosa (SIS) was used as a biomaterial due to its favorable composition, biological activity, and non-immunogenic properties. SIS was decellularized and characterized using scanning electron microscopy (SEM), hematoxylin and eosin (H&amp;E), and Masson's trichrome staining. Carboxymethyl cellulose (CMC) was employed as a supporting material, and ciprofloxacin (Cip) was incorporated as an antimicrobial agent to develop a novel hydrogel composite (SIS/CMC/Cip) with bioactive factors. This design was intended to create an optimal microenvironment for skin regeneration. The hydrogel exhibited an appropriate swelling ratio, tunable rheological properties, desirable drug release, and satisfactory degradation. <em>In vitro</em> assays demonstrated that our hydrogel enhanced cell viability without cytotoxic effects. Moreover, the hydrogel showed significant antibacterial activity against <em>Pseudomonas aeruginosa</em>, <em>Escherichia coli</em>, and <em>Staphylococcus aureus</em>. <em>In vivo</em> studies further confirmed the potential of the SIS/CMC/Cip hydrogel as a highly effective dressing for full-thickness wound repair. The designed hydrogel significantly accelerated wound healing in a rat model and effectively protected the wounds from bacterial invasion. In conclusion, the resulting hydrogel, with its excellent biocompatibility, offers a multifunctional approach and represents a promising candidate for advanced wound dressing applications.</div></div>","PeriodicalId":15600,"journal":{"name":"Journal of Drug Delivery Science and Technology","volume":"110 ","pages":"Article 107109"},"PeriodicalIF":4.5,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144184551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhanced delivery of Melittin via PEGylated PLGA nanoparticles: formulation, characterization, and in vitro evaluation","authors":"Abdullah K. Alshememry ,&nbsp;Mohd Abul Kalam ,&nbsp;Abdullah A. Alshehri ,&nbsp;Fahad A. Almughem ,&nbsp;Sulaiman S. Alhudaithi ,&nbsp;Raisuddin Ali ,&nbsp;Meshari M. Alamer ,&nbsp;Hamad S. Alzeer ,&nbsp;Ali A. Alamer ,&nbsp;Amjad N. Alotaibi ,&nbsp;Abeer H. Alomair ,&nbsp;Meshal K. Alnefaie ,&nbsp;Essam A. Tawfik ,&nbsp;Ziyad Binkhathlan","doi":"10.1016/j.jddst.2025.107101","DOIUrl":"10.1016/j.jddst.2025.107101","url":null,"abstract":"<div><div>Melittin (MEL), a major component of honeybee venom, possesses potent anti-inflammatory, antibacterial and anticancer properties. However, its clinical use is limited by its non-specific toxicity. This study investigates the nano-encapsulation of MEL into polyethylene glycol (PEG)-coated poly (lactic-co-glycolic acid) (PLGA) nanoparticles (PNPs) to mitigate these effects and improve its therapeutic efficacy. MEL-loaded PLGA NPs (MEL-PNPs) were successfully prepared by the double-emulsion solvent evaporation method, and PEG-4000 was employed as a coating agent. The MEL-PNPs and MEL-PNPs coated with PEG, had an optimal size of 165 ± 9 and 221 ± 7 nm, respectively with a high EE% of 79.1 % and 70.4 % and LC% of 7.7 ± 0.6 %, respectively. <em>In vitro</em> release studies demonstrated a slow and sustained release of MEL from both PNPs of &gt;85 % after eight days at two different pH conditions. Cytotoxicity study indicated that MEL-PNPs-PEG reduced the cytotoxicity against the normal cell line (HFF-1), maintaining a high cell viability after 72 h. In HepG2 cells, MEL-PNPs and MEL-PNPs-PEG showed enhanced anticancer activity, particularly after 48 h, with significant reductions in cell viability at higher concentrations. Also, B-PNPs and B-PNPs-PEG maintained the viability of HFF-1 and HepG2 cells at all concentrations till 72 h, indicating their safety. Antibacterial testing of MEL-loaded PNPs demonstrated significant inhibition of Gram–positive and Gram–negative pathogens. MEL-PNPs inhibited <em>S. aureus</em> and <em>MRSA</em> at 1.56 μg/mL, <em>E. coli</em> (ATCC 25922), <em>and P. aeruginosa</em> at 6.25 and 12 μg/mL, respectively, while MDR clinical isolates <em>E. coli</em> and <em>P. aeruginosa</em> both at 25 μg/mL. MEL-PNPs-PEG showed MICs of 0.78 and 1.56 μg/mL for <em>S. aureus</em> and <em>MRSA</em>, respectively, while for <em>E. coli</em> (ATCC 25922), <em>P. aeruginosa</em> (ATCC 27853), and MDR isolates of <em>E. coli</em> and <em>P. aeruginosa</em>, the MIC was in the range of 3.12–12.5 μg/mL. These findings suggest that the PEG-coated MEL-PNPs offer improved biocompatibility and more effective anticancer and antibacterial effects, making them a promising delivery system for MEL in cancer and infection therapy. An <em>in vivo</em> study is required to assess the performance of the developed MEL-loaded PNPs.</div></div>","PeriodicalId":15600,"journal":{"name":"Journal of Drug Delivery Science and Technology","volume":"110 ","pages":"Article 107101"},"PeriodicalIF":4.5,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144169329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preparation of antibacterial tellurium nanorod-incorporated thermosensitive pluronic F-127 hydrogels for wound healing applications","authors":"Yuting Chen ,&nbsp;Anbazhagan Sathiyaseelan ,&nbsp;Xin Zhang ,&nbsp;Yingshan Jin ,&nbsp;Myeong-Hyeon Wang","doi":"10.1016/j.jddst.2025.107107","DOIUrl":"10.1016/j.jddst.2025.107107","url":null,"abstract":"<div><div>Drug-resistant bacterial infections pose significant challenges to wound healing, highlighting the urgent need for innovative multifunctional wound-healing materials. Tellurium (Te) nanomaterials (NMs) have been successfully utilized in antimicrobial agents, while thermosensitive hydrogels have demonstrated promise in preventing implant-related infections. In this study, Te NMs were synthesized using pineapple peel (PP) extracts under optimized conditions. Their bioactivity and wound-healing potential were then evaluated after incorporation into Pluronic F-127 (PF-127) hydrogel. PP-Te nanorods (NRs) exhibited a rod-like shape and a homogeneous dispersion within the hydrogel network structure. The average sizes of PP-Te NRs and PP-Te NRs/PF-127 were 148.7 ± 19.8 nm and 36.6 ± 17.6 nm, respectively. Their functional characteristics and crystalline structures were confirmed through FTIR and XRD analysis. The PP-Te NRs/PF-127 hydrogel demonstrated a higher release of Te ions and degradable capacity in a wound environment. Both PP-Te NRs and PP-Te NRs/PF-127 exhibited strong antibacterial activity, inhibiting bacterial growth (<em>E. coli</em>: MIC₉₀ &lt; 1.9 and 3.41 μg/mL), preventing biofilm formation, and disrupting bacterial cell membranes. Furthermore, PP-Te NRs and PP-Te NRs/PF-127 hydrogel demonstrated excellent <em>in vitro</em> wound-healing efficacy (98.6 % closure within 36 h), exhibiting low hemolysis (&lt;5 %) and high biocompatibility in HaCaT cells (cell viability &gt;90 %). These findings highlight the significant potential of PP-Te NRs and PP-Te NRs/PF-127 hydrogel as multifunctional agents for wound-healing applications.</div></div>","PeriodicalId":15600,"journal":{"name":"Journal of Drug Delivery Science and Technology","volume":"111 ","pages":"Article 107107"},"PeriodicalIF":4.5,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144212220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}