Formulation screening for local delivery of mRNA and photosensitizer to treat superficial tumor

IF 4.9 3区医学 Q1 PHARMACOLOGY & PHARMACY

Journal of Drug Delivery Science and Technology Pub Date : 2025-09-11 DOI:10.1016/j.jddst.2025.107525

Lei huang , Siyuan Tang , Jiachen Guo , Yixing Tu , Sian Li , Taihua Yang , Dong Zhao , Chao Wang

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Abstract

Localized delivery of mRNA-based therapies has shown promise in cancer treatment, but challenges such as drug leakage and systemic toxicity remain. This study aimed to develop a locally retained lipid nanoparticle (LNP) system for the co-delivery of mRNA and the photosensitizer indocyanine green (ICG) to treat superficial tumors. By systematically optimizing the lipid composition and mRNA-to-ICG ratio, we achieved high encapsulation efficiency and localized protein expression. The LNP system demonstrated robust transfection efficiency and photothermal effects, with minimal off-target distribution. In vivo studies revealed significant tumor growth inhibition, highlighting the potential of this approach for localized cancer therapy. This study provides a novel strategy for the co-delivery of mRNA and photosensitizers, offering a promising avenue for the treatment of superficial tumors with minimal systemic exposure.

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mRNA和光敏剂局部递送治疗浅表肿瘤的配方筛选

基于mrna的局部递送疗法在癌症治疗中显示出希望，但诸如药物泄漏和全身毒性等挑战仍然存在。本研究旨在开发一种局部保留的脂质纳米颗粒（LNP）系统，用于共同递送mRNA和光敏剂吲哚菁绿（ICG）来治疗浅表肿瘤。通过系统优化脂质组成和mrna - icg比例，我们实现了高包封效率和局部蛋白表达。LNP系统表现出强大的转染效率和光热效应，具有最小的脱靶分布。体内研究显示了显著的肿瘤生长抑制作用，突出了这种方法在局部癌症治疗中的潜力。这项研究为mRNA和光敏剂的共同递送提供了一种新的策略，为以最小的全身暴露治疗浅表肿瘤提供了一条有希望的途径。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Drug Delivery Science and Technology 医学-药学

CiteScore

8.00

自引率

8.00%

发文量

879

审稿时长

94 days

期刊介绍： The Journal of Drug Delivery Science and Technology is an international journal devoted to drug delivery and pharmaceutical technology. The journal covers all innovative aspects of all pharmaceutical dosage forms and the most advanced research on controlled release, bioavailability and drug absorption, nanomedicines, gene delivery, tissue engineering, etc. Hot topics, related to manufacturing processes and quality control, are also welcomed.