Journal of Community Hospital Internal Medicine Perspectives最新文献_第3页

Oropharyngeal Lymphogranuloma Venereum: A Clinical Reasoning Challenge and Literature Review. 口咽淋巴肉芽肿性病：临床推理挑战和文献回顾。

IF 0.9

Journal of Community Hospital Internal Medicine Perspectives Pub Date : 2025-01-06 eCollection Date: 2025-01-01 DOI: 10.55729/2000-9666.1439

Andrew D Vogel, Anthony Asta, Hussam Ammar

引用次数: 0

Pulmonary Embolism in Long Standing Diabetes: A Hint Towards Pancreatic Carcinoma. 长期糖尿病的肺栓塞：胰腺癌的提示。

IF 0.9

Journal of Community Hospital Internal Medicine Perspectives Pub Date : 2025-01-06 eCollection Date: 2025-01-01 DOI: 10.55729/2000-9666.1429

Anish K Shrestha, Christopher Haas

引用次数: 0

Serum Lactate Dehydrogenase Levels: The Grim Reaper Sign in Acute Pancreatitis? 血清乳酸脱氢酶水平：急性胰腺炎的死神标志？

IF 0.9

Journal of Community Hospital Internal Medicine Perspectives Pub Date : 2025-01-06 eCollection Date: 2025-01-01 DOI: 10.55729/2000-9666.1430

George Trad, Jackson Hoekstra, Rakahn Haddadin, Kartika Shetty, John Ryan

{"title":"Serum Lactate Dehydrogenase Levels: The Grim Reaper Sign in Acute Pancreatitis?","authors":"George Trad, Jackson Hoekstra, Rakahn Haddadin, Kartika Shetty, John Ryan","doi":"10.55729/2000-9666.1430","DOIUrl":"10.55729/2000-9666.1430","url":null,"abstract":"Background and aims: Acute pancreatitis (AP) frequently presents in emergency departments and poses challenges in predicting severity and mortality. Established scoring systems like Ranson criteria, Acute Physiology And Chronic Health Evaluation II (APACHE) II, and Bedside Index of Severity in Acute Pancreatitis (BISAP) have varying effectiveness. Lactate dehydrogenase (LDH), an enzyme released during tissue damage, shows promise as a marker for organ injury in AP. This study aimed to evaluate LDH's potential to predict mortality risk and hospital stay duration in AP patients.Methods: A retrospective cohort study analyzed AP cases at HCA Healthcare facilities from January 2011 to January 2021. Among 514 patients with LDH data at admission, groups were categorized based on LDH levels. Outcomes included hospital and ICU stay lengths, mortality rates, and factors such as age, gender, race, BMI, and medical history.Results: Patients were stratified into three groups: Group 1 (<300 IU/L), Group 2 (300-600 IU/L), and Group 3 (>600 IU/L) based onLDHlevels. Patients withLDH>600 IU/L experienced an average hospital stay extension of 4.5 days,were 3.2 times more likely to require ICU admission, and faced a 12.1 times higher mortality risk compared to those with LDH <300 IU/L.Conclusion: This study highlights LDH as a potentially valuable predictor of hospital stay duration, ICU requirements, and mortality rates in AP patients. Its cost-effectiveness and accessibility suggest LDH testing could aid clinical decision-making in AP management. Future prospective studies should further explore LDH's role in optimizing AP patient care.","PeriodicalId":15460,"journal":{"name":"Journal of Community Hospital Internal Medicine Perspectives","volume":"15 1","pages":"8-12"},"PeriodicalIF":0.9,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11759084/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143046851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Insulin Therapy for Acute Pancreatitis in a Patient With Lipase Maturation Factor 1 Mutation: A Case Report. 胰岛素治疗脂肪酶成熟因子1突变患者急性胰腺炎一例报告。

IF 0.9

Journal of Community Hospital Internal Medicine Perspectives Pub Date : 2025-01-06 eCollection Date: 2025-01-01 DOI: 10.55729/2000-9666.1431

Neha Bhaskar, Aram Bejnood, Christopher D Jackson

引用次数: 0

Whip-it Beyond Desserts: Causing Subacute Combined Degeneration - Case Report and Literature Review. 甜品之外的鞭子：引起亚急性合并变性-个案报告及文献复习。

IF 0.9

Journal of Community Hospital Internal Medicine Perspectives Pub Date : 2025-01-06 eCollection Date: 2025-01-01 DOI: 10.55729/2000-9666.1450

Vijayalakshmi Brahmashettar, Elton Ahadov, Tamilla Rzayeva, Westley T Hartley, Nargiz Muganlinskaya

{"title":"Whip-it Beyond Desserts: Causing Subacute Combined Degeneration - Case Report and Literature Review.","authors":"Vijayalakshmi Brahmashettar, Elton Ahadov, Tamilla Rzayeva, Westley T Hartley, Nargiz Muganlinskaya","doi":"10.55729/2000-9666.1450","DOIUrl":"10.55729/2000-9666.1450","url":null,"abstract":"Nitrous oxide (N2O) has been increasingly used for recreational purposes due to its dissociative and euphoric properties. Exposure to N2O results in the deactivation of in vivo vitamin B12, leading to subsequent neurological sequelae due to vitamin B12 deficiency.7 Current management focuses on cessation of exposure and replacement therapy, yet patients may continue to suffer from permanent neurological damage.12 We report a case of a 50-year-old woman who presented with impaired balance, a subacute decline in mental status, multiple falls, and back pain. She was hospitalized for evaluation of her presenting symptoms and for pain management. The patient's sister helped uncover the patient's misuse of N2O via \"Whip-it!\" cartridges. Physical examination, along with magnetic resonance imaging of the cervical and thoracic spine, confirmed the diagnosis of subacute combined degeneration (SCD), and appropriate treatment was initiated. Our case aims to bring attention to this seemingly harmless recreational drug that continues to regain popularity and its association with brain and nerve damage.13.","PeriodicalId":15460,"journal":{"name":"Journal of Community Hospital Internal Medicine Perspectives","volume":"15 1","pages":"111-114"},"PeriodicalIF":0.9,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11759066/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143046990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical Characteristics, Microbiological and Risk Factors of Infections in Patients With Systemic Lupus Erythematosus. 系统性红斑狼疮患者感染的临床特点、微生物学及危险因素。

IF 0.9

Journal of Community Hospital Internal Medicine Perspectives Pub Date : 2025-01-06 eCollection Date: 2025-01-01 DOI: 10.55729/2000-9666.1447

Guanhua Li, Xiaojing Liu, Jiakang Zhao

{"title":"Clinical Characteristics, Microbiological and Risk Factors of Infections in Patients With Systemic Lupus Erythematosus.","authors":"Guanhua Li, Xiaojing Liu, Jiakang Zhao","doi":"10.55729/2000-9666.1447","DOIUrl":"10.55729/2000-9666.1447","url":null,"abstract":"Objective: To determine risk factors, clinical and microbiological characteristics of infections in a single-center systemic lupus erythematosus (SLE) cohort.Methods: All hospital patients in The First Affiliated Hospital of Zhengzhou University from 2019 to 2021 who meet ≥4 ACR-97 SLE criteria were identified. Patients with infection and without infection were included with a ratio of 1:2.Results: 687 SLE patients were identified and 224 patients with infection and 448 patients without infection were included. The most common microorganisms in the infection group were Escherichia coli, Herpes zoster and Aspergillus, respectively. In the cox regression analysis, nephritis (OR 1.785; 95% CI: 1.156-2.756), diabetes(OR 6.507; 95% CI: 2.692-15.725), CD4+ T cell (OR 1.003; 95% CI: 1.002-1.004), prednisone>10 mg/day (OR 1.879; 95% CI: 1.112-3.175), immunosuppressants (OR 0.465; 95% CI: 0.310-0.697) and SLEDAI score (OR 0.866; 95% CI: 0.837-0.896) were risk factors associated with infection.Conclusions: Bacteria was the most common infection in SLE patients with the respiratory tract being the most common site. Nephritis, diabetes, SLEDAI score were associated with infection. Monitoring CD4+ T cell can predict the infection incidence. Prednisone (>10 mg/day) and immunosuppressants increase the occurrence of infection.","PeriodicalId":15460,"journal":{"name":"Journal of Community Hospital Internal Medicine Perspectives","volume":"15 1","pages":"36-41"},"PeriodicalIF":0.9,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11759075/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143046784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Severe Hypercalcemia Following Hip Joint Implantation of Calcium Sulfate Antibiotic Beads: Case Series and Review of Literature. 髋关节植入硫酸钙抗生素珠后的严重高钙血症：病例系列和文献综述。

IF 0.9

Journal of Community Hospital Internal Medicine Perspectives Pub Date : 2025-01-06 eCollection Date: 2025-01-01 DOI: 10.55729/2000-9666.1449

Andrew P Demidowich, Mahsa Motevalli, Kevin Yi, Atena Kamali, Kristine Batty, Kendall F Moseley, Robert R Buber, Mehdi Hashemipour, Mihail Zilbermint

{"title":"Severe Hypercalcemia Following Hip Joint Implantation of Calcium Sulfate Antibiotic Beads: Case Series and Review of Literature.","authors":"Andrew P Demidowich, Mahsa Motevalli, Kevin Yi, Atena Kamali, Kristine Batty, Kendall F Moseley, Robert R Buber, Mehdi Hashemipour, Mihail Zilbermint","doi":"10.55729/2000-9666.1449","DOIUrl":"10.55729/2000-9666.1449","url":null,"abstract":"Purpose: The diagnosis and management of hypercalcemia in hospitalized patients can be challenging. Hypercalcemia is often associated with significant morbidity and end-organ damage which may delay a patient's recovery.Methods: We report a case series of three patients who underwent orthopedic procedures with intraoperative placement of vancomycin-loaded calcium sulfate beads. Patients had no known history of malignancy or excess intake of calcium, vitamin A or vitamin D. Laboratory workup showed low parathyroid (PTH) levels and normal PTH-related peptide levels. The temporal nature of the non-PTH mediated hypercalcemia in relation to implantation of the antibiotic beads suggests causality of exogenous calcium sulfate with the patients' subsequent hypercalcemia.Results: Patients were treated with aggressive intravenous saline and zoledronic acid resulting in resolution of hypercalcemia in all cases. The antibiotic impregnated beads did not require explantation.Conclusion: Hypercalcemia following calcium sulfate antibiotic bead implantation may contribute to patient morbidity and increased length-of-stay. We recommend serum calcium and creatinine be closely monitored during the early postoperative period in patients who receive calcium sulfate antibiotic beads.","PeriodicalId":15460,"journal":{"name":"Journal of Community Hospital Internal Medicine Perspectives","volume":"15 1","pages":"107-110"},"PeriodicalIF":0.9,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11759080/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143046926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gene Editing: Developments, Ethical Considerations, and Future Directions. 基因编辑：发展、伦理考虑和未来方向。

IF 0.9

Journal of Community Hospital Internal Medicine Perspectives Pub Date : 2025-01-06 eCollection Date: 2025-01-01 DOI: 10.55729/2000-9666.1445

Manav C Parikh

引用次数: 0

MAFLD: Exploring the Systemic Effects Beyond Liver. MAFLD：探索肝脏以外的全身效应。

IF 0.9

Journal of Community Hospital Internal Medicine Perspectives Pub Date : 2025-01-06 eCollection Date: 2025-01-01 DOI: 10.55729/2000-9666.1426

Utkarsh Dayal, Ujjwal Soni, Sourav Bansal, Kanishk Aggarwal, Chaitanya Chennupati, Sai G Kanagala, Vasu Gupta, Ripudaman S Munjal, Rohit Jain

{"title":"MAFLD: Exploring the Systemic Effects Beyond Liver.","authors":"Utkarsh Dayal, Ujjwal Soni, Sourav Bansal, Kanishk Aggarwal, Chaitanya Chennupati, Sai G Kanagala, Vasu Gupta, Ripudaman S Munjal, Rohit Jain","doi":"10.55729/2000-9666.1426","DOIUrl":"10.55729/2000-9666.1426","url":null,"abstract":"Metabolic dysfunction-associated fatty liver disease (MAFLD) is a growing global health concern which is driven by the increasing prevalence of diabetes and obesity. MAFLD is characterized by excessive fat accumulation in the liver, which encompasses a range of conditions, from simple hepatic steatosis to more severe forms. This condition is associated with various complications, including chronic kidney disease (CKD), Cardiovascular Disease (CVD), liver cirrhosis, and even malignancy. Recent research has highlighted a potential connection between gut dysbiosis and MAFLD, particularly in relation to CKD. This has underscored the significance of the gut-liver-kidney axis in understanding MAFLD's pathogenesis. Inflammation triggered by MAFLD increases the risk of CVD through multiple mechanisms linked to metabolic dysfunction. These mechanisms include heightened oxidative stress, systemic and hepatic insulin resistance, low-grade inflammation, and endothelial dysfunction. Hepatic steatosis and metabolic dysfunction are major diagnostic criteria for MAFLD, often coexisting with other liver ailments. This prospective review emphasizes the intricate associations between MAFLD, cardiovascular complications, renal issues, and hepatic diseases. Understanding the underlying pathophysiological pathways is crucial in comprehending the increased risk of CKD, CVD, and other hepatic complications in individuals with MAFLD.","PeriodicalId":15460,"journal":{"name":"Journal of Community Hospital Internal Medicine Perspectives","volume":"15 1","pages":"42-48"},"PeriodicalIF":0.9,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11759081/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143046883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Validation of SCAI Shock Staging in Critically Ill Medical Intensive Care Unit Patients With Sepsis and Septic Shock. 重症监护病房脓毒症和感染性休克危重患者SCAI休克分期的验证

IF 0.9

Journal of Community Hospital Internal Medicine Perspectives Pub Date : 2025-01-06 eCollection Date: 2025-01-01 DOI: 10.55729/2000-9666.1436

Osama Mukhtar, Amos Lal, Jacob Jentzer, Kianoush Kashani

{"title":"Validation of SCAI Shock Staging in Critically Ill Medical Intensive Care Unit Patients With Sepsis and Septic Shock.","authors":"Osama Mukhtar, Amos Lal, Jacob Jentzer, Kianoush Kashani","doi":"10.55729/2000-9666.1436","DOIUrl":"10.55729/2000-9666.1436","url":null,"abstract":"Purpose: This study evaluated the predictive value of SCAI shock staging for mortality in patients with sepsis and septic shock admitted to the medical ICU.Materials and methods: This is a single-center historical cohort study. We analyzed data for adults (≥18-year-old) admitted to the medical ICU at Mayo Clinic St. Mary's campus with sepsis between June 1, 2018, and December 31, 2021. Sepsis was identified using the Sepsis-III criteria. Patients were stratified based on SCAI shock staging. Our primary outcome was all-cause 30-day mortality.Results: We identified 3079 eligible adult patients with sepsis or septic shock. The distribution of SCAI shock stages A through E was 9%, 12%, 25%, 49%, and 5%, respectively. The overall 30-day mortality was 24%. There was progression in all outcomes including ICU, hospital and 30-day mortality across SCAI shock stages. However, only SCAI shock stages D and E, had statistically significant adjusted HRs of 1.6 and 3, respectively. When compared to SOFA score, SCAI shock staging performed similarly in predicting ICU mortality with no statistically significant difference in AUCs, p-value of 0.07.Conclusions: Our results support the use of SCAI shock staging in critically ill medical patients with sepsis and septic shock for risk stratification. We propose that the SCAI shock staging may be used as a universal system for grading the severity of shock in critically ill patients regardless of etiology.","PeriodicalId":15460,"journal":{"name":"Journal of Community Hospital Internal Medicine Perspectives","volume":"15 1","pages":"13-21"},"PeriodicalIF":0.9,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11759074/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143046986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0