Journal of Community Hospital Internal Medicine Perspectives最新文献

{"title":"Evolving Trends and Racial Disparities in Alcohol Associated Liver Disease (ALD), Metabolic Dysfunction Associated Steatohepatitis (MASH) and Hepatitis C Viral Infection (HCV) as Etiology of Liver Transplantation: Past, Present, and Future Projections.","authors":"Boniface Mensah, Albert E Orhin, Natalie A Y Akoto, Seunghee Han, Rachel A Boateng, Ramya Varesiddy, Joseph Atarere, Simardeep Singh, Terrylyna Baffoe-Bonnie, Haider Naqvi, Christopher J Haas","doi":"10.55729/2000-9666.1606","DOIUrl":"10.55729/2000-9666.1606","url":null,"abstract":"<p><strong>Background: </strong>Liver transplantation remains the definitive treatment for end-stage liver disease (ESLD) and hepatocellular carcinoma (HCC). While hepatitis C virus (HCV) was historically the leading indication for liver transplant, the introduction of direct-acting antivirals (DAAs) has drastically reduced HCV-related ESLD. In contrast, metabolic dysfunction-associated steatohepatitis (MASH) and alcohol-associated liver disease (ALD) have emerged as predominant causes of liver transplantation. This study evaluates racial and ethnic disparities in liver transplantation indications from 2004 to 2023 and projects future trends through to 2040.</p><p><strong>Methods: </strong>De-identified data from the Standard Transplant Analysis and Research (STAR) files of the United Network for Organ Sharing (UNOS) database were analyzed to assess temporal trends in the proportion of ALD, HCV, and MASH as etiologies of liver transplant indications using Joinpoint regression. The annual percentage change (APC) in the proportion of etiologies of liver transplantation were reported with a significance level at a p-value of 0.5. Future projections were estimated using the Box-Jenkins methodology of Autoregressive Integrated Moving Average (ARIMA) modelling. Trends were stratified by race/ethnicity to evaluate disparities.</p><p><strong>Results: </strong>The proportion of liver transplantation attributed to ALD has risen significantly across all racial groups, with American Indian/Alaska Native (AIAN) individuals experiencing the steepest increase. By 2040, ALD is projected to account for 80% of liver transplantation in AIAN populations. MASH-related liver transplantation is also increasing, particularly among Hispanic and White individuals, with projections reaching approximately 40% by 2040. In contrast, HCV-related liver transplantation has sharply declined across all racial groups likely due to the impact of DAAs, however, the Black population continues to experience disproportionately higher rates of HCV-related ESLD.</p><p><strong>Conclusion: </strong>The shifting landscape of liver transplantation etiologies highlights the growing burden of ALD and MASH, emphasizing the need for targeted prevention strategies. Persistent racial disparities in liver transplant access and outcomes underscore systemic healthcare inequities. Addressing these disparities through equitable healthcare policies, early intervention programs, and improved transplant access is crucial to ensuring fair distribution of transplant resources and improved outcomes for all populations.</p>","PeriodicalId":15460,"journal":{"name":"Journal of Community Hospital Internal Medicine Perspectives","volume":"16 4","pages":"36-45"},"PeriodicalIF":0.6,"publicationDate":"2026-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13496479/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148793754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Echocardiography in Stroke Management: Necessary or Overused?","authors":"Nicole Ann Tesoro, Jasvin K Manha, Jerold Fleishman, Sumanth Bandaru","doi":"10.55729/2000-9666.1624","DOIUrl":"10.55729/2000-9666.1624","url":null,"abstract":"<p><p>Stroke remains a leading cause of morbidity and mortality worldwide, leading to the development of efficient and evidence-based management strategies. Echocardiography is a crucial diagnostic tool for identifying cardiac sources of embolism, particularly in cardioembolic and cryptogenic strokes, yet its routine use in all stroke patients remains controversial. While evidence-based guidelines recommend a patient-specific approach, rigid hospital quality metrics have incentivized widespread echocardiography, even in low-yield cases such as large artery atherosclerotic strokes. This disconnect raises concerns regarding cost-effectiveness, resource allocation, and potential over-testing, delaying discharges and prolonging hospital length of stay. A more tailored approach, focusing on guideline-driven indications, is necessary to optimize stroke care. Future research should refine diagnostic criteria and align quality metrics with evidence-based practices to ensure high-value, patient-centered stroke management.</p>","PeriodicalId":15460,"journal":{"name":"Journal of Community Hospital Internal Medicine Perspectives","volume":"16 4","pages":"74-80"},"PeriodicalIF":0.6,"publicationDate":"2026-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13496506/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148793794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Case of Anti-SRP Immune-mediated Necrotizing Myopathy Following Suspected Coxsackie B4 Infection: Exploring a Viral Trigger Hypothesis.","authors":"Marwan Ahmed, Ruba Salameh, Soziema Salia, Brent T Harris, Christopher J Haas, Anees Siddiqi","doi":"10.55729/2000-9666.1603","DOIUrl":"10.55729/2000-9666.1603","url":null,"abstract":"<p><p>Immune-mediated necrotizing myopathy (IMNM) is a rare subtype of idiopathic inflammatory myopathies that can present with rhabdomyolysis. We report a 43-year-old woman with rapidly progressive proximal muscle weakness following a flu-like illness. Laboratory evaluation revealed markedly elevated creatine kinase (22,207 U/L) and transaminases, with positive anti-signal recognition particle (SRP) and Coxsackie B4 antibodies. Muscle biopsy demonstrated extensive necrosis, regeneration, and endomysial lymphocytic infiltration, confirming IMNM. The patient was treated with intravenous methylprednisolone, IVIG, and rituximab, followed by oral steroid taper and mycophenolate. At six-month follow-up, she showed significant clinical and biochemical improvement. This case highlights a potential viral-triggered autoimmune mechanism, suggesting that Coxsackie B4 infection may initiate or amplify anti-SRP-mediated immune muscle injury. Greater awareness of viral associations may aid early diagnosis and targeted therapy of IMNM.</p>","PeriodicalId":15460,"journal":{"name":"Journal of Community Hospital Internal Medicine Perspectives","volume":"16 4","pages":"124-129"},"PeriodicalIF":0.6,"publicationDate":"2026-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13496469/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148793478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic Utility of Delta-Procalcitonin and Modified Shock Index for Risk Stratification of Sepsis in Acute Care Settings.","authors":"Sanveer Singh, Neeraj Singla, Navneet Sharma, Mandip Bhatia, Saurabh C Sharda","doi":"10.55729/2000-9666.1631","DOIUrl":"10.55729/2000-9666.1631","url":null,"abstract":"<p><strong>Background: </strong>Risk stratification in sepsis remains challenging, and while several scoring systems exist, there is a need for simple tools that can reliably predict outcomes.</p><p><strong>Aims: </strong>To study the role of Delta-Procalcitonin and Modified Shock Index (MSI) in predicting the severity of Multiple Organ Dysfunction Syndrome (MODS)like acute kidney injury, vasopressor requirement, need for mechanical ventilation, coagulopathy and 28 day mortality in sepsis.</p><p><strong>Methods: </strong>This prospective observational study recruited 122 patients with suspected sepsis. Delta-Procalcitonin was calculated by measuring the difference in procalcitonin values at the time of admission and after 48 h. Modified Shock Index (MSI) is calculated by \"dividing heart rate by mean arterial pressure (MAP).\" Procalcitonin and MSI were assessed by Receiver Operating Characteristic (ROC) curve analysis.</p><p><strong>Results: </strong>There's a statistically significant association between delta procalcitonin and the incidence of AKI (p = 0.035), the vasopressor requirement (p = 0.032), coagulopathy (p = 0.015) and no statistically significant association between delta procalcitonin and the need for renal replacement therapy (RRT) (p = 0.670), the mechanical ventilation requirement (p = 0.310), need for blood products (p = 0.57), number of organ dysfunctions(p = 0.344),and 28 day mortality (p = 0.138). The mortality rate was higher in the MSI ≥1.2 group (18.9%) compared to the MSI <1.2 group (11.5%).</p><p><strong>Conclusion: </strong></p><p><strong>Delta: </strong>Procalcitonin was associated with predicting the severity of acute kidney injury, vasopressor requirement and coagulopathy. MSI had a statistically significant association with the prediction of vasopressor requirement, coagulopathy, and the number of organ dysfunctions.</p>","PeriodicalId":15460,"journal":{"name":"Journal of Community Hospital Internal Medicine Perspectives","volume":"16 4","pages":"46-54"},"PeriodicalIF":0.6,"publicationDate":"2026-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13496466/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148793792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of Pre-treatment CA 125 Levels on Survival Outcomes Across Ethnic Groups in Ovarian Cancer Patients.","authors":"Ayrton Bangolo, Behzad Amoozgar, Lili Zhang, Budoor Alqinai, Lejla Hodzic, Prathyusha Nadella, Mudra Patel, Kaushik Roy, Veena Lakshmana, Nirdosh Sharma, Sabrina Sultana, Berhane Yohannes, Hadrian Hoang-Vu Tran, Gabriel Ingersoll, Phyu Min Thet, Roshini W Senevirathne, Prajwal Chandak, Nicole Maharaj, Chloe Aloimonos, Mehwish Safdar, Chathurika Priyabhashinie, Betsy Samuel, Maheswari Bommepalli, Ye Tun, Steven Swarath, Naresh Kumar, Rishabh Goyal, Sami Ai Salih, Isaac O Wiredu, Elena Umanets, Lisette L Kiadidi, Prasansa Dhakal, Timerjot Kaur, Dengyumei Du, Komaldeep Gill, Muhammad Ali Raza Khan, Camila Arteaga, Helena Barbosa, Simcha Weissman","doi":"10.55729/2000-9666.1629","DOIUrl":"10.55729/2000-9666.1629","url":null,"abstract":"<p><strong>Aim: </strong>This study evaluates demographics, clinicopathological features, and mortality influencers among 16,466 US patients with ovarian cancer diagnosed between 2010 and 2017, focusing on CA 125 levels and racial disparities affecting outcomes.</p><p><strong>Methods: </strong>We analyzed SEER data for 16,466 patients diagnosed from 2010 to 2017. Demographic, clinical, overall mortality (OM), and cancer-specific mortality (CSM) variables were assessed. Factors with P < 0.1 on univariate Cox regression were entered into multivariate Cox models to identify independent prognostic factors, with hazard ratios greater than one indicating adverse prognosis.</p><p><strong>Results: </strong>Among 16,466 patients with ovarian cancer diagnosed between 2010 and 2017, most were aged 40-79 years and presented with distant-stage disease. The majority of patients were non-Hispanic White, followed by Hispanic and non-Hispanic Black patients. Serous carcinoma was the most common histologic subtype, and most tumors were poorly differentiated or undifferentiated. Multivariate analysis identified age, marital status, tumor stage, race, tumor subtype, tumor grade, CA-125 level, chemotherapy, and surgery as significant predictors of survival. Hispanic patients with borderline CA-125 levels demonstrated higher mortality risk, whereas elevated CA-125 levels were not significantly associated with increased mortality among non-Hispanic Black patients.</p><p><strong>Conclusion: </strong>These findings emphasize early detection, personalized treatment, and social support to improve outcomes. Persistent racial disparities, independent of CA 125 levels, highlight the need for targeted research and interventions. This study adds to existing literature and supports continued efforts to enhance screening, treatment, and supportive care for ovarian cancer patients, particularly to address inequities in survival nationwide. Future studies should integrate biomarker stratification with equity-focused clinical strategies.</p>","PeriodicalId":15460,"journal":{"name":"Journal of Community Hospital Internal Medicine Perspectives","volume":"16 4","pages":"26-35"},"PeriodicalIF":0.6,"publicationDate":"2026-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13496472/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148793778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corynebacterium Bacteremia in a High-risk Host: A Diagnostic Dilemma of Contamination Versus True Infective Endocarditis.","authors":"Arman Manjikian, Christopher Aboujaoude, Nicole Rock, Don Pepito","doi":"10.55729/2000-9666.1633","DOIUrl":"10.55729/2000-9666.1633","url":null,"abstract":"<p><p><i>Corynebacterium</i> species are often regarded as skin contaminants when isolated from clinical cultures. However, in select high-risk patients, these organisms can lead to significant infections, including infective endocarditis. We present the case of a 76-year-old woman with multiple comorbidities, including end stage renal disease (ESRD) on hemodialysis and an exposed tunneled central catheter, who developed <i>Corynebacterium</i>-associated native mitral valve endocarditis requiring surgical intervention. Despite prompt antimicrobial therapy and bioprosthetic valve replacement, her hospital course was complicated by heart block, empyema, and eventual cardiac arrest. This case highlights the importance of recognizing <i>Corynebacterium</i> as a potential pathogen in vulnerable patients and reviewing the growing body of literature on this rare but serious cause of endocarditis.</p>","PeriodicalId":15460,"journal":{"name":"Journal of Community Hospital Internal Medicine Perspectives","volume":"16 4","pages":"143-146"},"PeriodicalIF":0.6,"publicationDate":"2026-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13496485/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148793759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improving Pneumococcal Vaccination Rates During Hospitalization via Resident Education Intervention: A Hospital-Based Quality Improvement Project in a Teaching Community Hospital.","authors":"Shun Nakahara, Takahiko Tsutsumi, Masaru Kurihara","doi":"10.55729/2000-9666.1627","DOIUrl":"10.55729/2000-9666.1627","url":null,"abstract":"<p><strong>Background: </strong>Pneumococcal vaccination coverage among eligible adults in Japan remains suboptimal. This gap may be partly attributable to insufficient physician and patient education, as well as limited coordination in delivery of preventive care. Therefore, we conducted a hospital-based quality improvement project combining resident education with system-level workflow modifications to enhance pneumococcal vaccination rates.</p><p><strong>Methods: </strong>A single-center quality improvement study was conducted at a teaching community hospital in Japan, comparing outcomes between pre-intervention and intervention periods. The intervention included resident education, patient educational materials, integration of vaccination status into admission documentation, discharge checklists, and weekly reminders. The primary outcome was the proportion of eligible patients vaccinated during hospitalization, while secondary outcomes included overall vaccination rates at discharge. Process measures assessed residents' knowledge and confidence before and after the educational session.</p><p><strong>Results: </strong>During the pre-intervention period, 40 eligible patients were identified, and none were vaccinated (0%). During the intervention period, 36 eligible patients were identified, of whom 29 (80.6%) were vaccinated. Overall vaccination rates at discharge increased from 22.4% (22/98) to 59.5% (50/84). Among 15 residents, mean knowledge scores improved from 57% to 92%, and confidence in counseling increased from 2.0 to 4.4 on a 5-point Likert scale.</p><p><strong>Conclusions: </strong>A resident-led, hospital-based quality improvement intervention substantially increased pneumococcal vaccination rates among eligible hospitalized patients. Educational initiatives combined with system-level workflow modifications represent a practical strategy to improve adult vaccination coverage in inpatient settings.</p>","PeriodicalId":15460,"journal":{"name":"Journal of Community Hospital Internal Medicine Perspectives","volume":"16 4","pages":"13-18"},"PeriodicalIF":0.6,"publicationDate":"2026-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13496486/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148793802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vitamin B12 Deficiency Mimicking Thrombotic Microangiopathy: A Case of Pseudo-Thrombotic Microangiopathy.","authors":"Maya Pillai, Sandesh Parajuli, Bidisha Baral, Rachael McClenahan, Shoja Rahimian","doi":"10.55729/2000-9666.1594","DOIUrl":"https://doi.org/10.55729/2000-9666.1594","url":null,"abstract":"<p><strong>Introduction: </strong>Vitamin B12 deficiency may rarely present with hemolysis and schistocytosis, mimicking thrombotic microangiopathy (TMA). This pseudo-TMA variant is clinically significant, as delayed recognition may lead to unnecessary treatments and adverse outcomes.</p><p><strong>Case presentation: </strong>A 44-year-old male with no significant medical history or dietary restrictions presented with progressive lightheadedness, epigastric discomfort, and unintentional weight loss. Laboratory evaluation revealed macrocytic anemia with evidence of hemolysis and reticulocytopenia. A negative Coombs test made autoimmune hemolytic anemia less likely. Further workup demonstrated low serum vitamin B12 and elevated methylmalonic acid, consistent with B12 deficiency. Upper endoscopy with gastric biopsy revealed atrophic mucosa lacking parietal cells, and serology was positive for anti-parietal cell and intrinsic factor antibodies, confirming pernicious anemia. The patient was treated with intramuscular vitamin B12, resulting in rapid hematologic recovery and complete resolution of symptoms.</p><p><strong>Conclusion: </strong>This case illustrates a rare presentation of pernicious anemia as pseudo-TMA, emphasizing the importance of recognizing macrocytosis and reticulocytopenia as distinguishing features from true TMA. Early identification of vitamin B12 deficiency can prevent unnecessary invasive interventions and allows for rapid clinical improvement with supplementation.</p>","PeriodicalId":15460,"journal":{"name":"Journal of Community Hospital Internal Medicine Perspectives","volume":"16 3","pages":"23-26"},"PeriodicalIF":0.6,"publicationDate":"2026-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13493001/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148793527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adrenal Crisis Induced-seizures: A Case Report and Literature Review.","authors":"Israel Umoh, Elizabeth Mikhail, Narjis Batool, Nosheen Hajra, Ibrahim Al-Sanouri","doi":"10.55729/2000-9666.1593","DOIUrl":"https://doi.org/10.55729/2000-9666.1593","url":null,"abstract":"<p><p>This case report underscores the critical interplay between adrenal crisis and seizure activity, emphasizing the importance of rapid recognition and management of this life-threatening condition. Adrenal crisis, characterized by severe hypotension and electrolyte disturbances, often manifests with nonspecific symptoms such as fatigue, nausea, and altered consciousness, which can obscure diagnosis, especially in pediatric and young adult populations. The report details a 21-year-old female with a complex endocrinologic background who developed seizures precipitated by an adrenal crisis triggered by gastroenteritis and compounded by medication noncompliance. Clinical findings included profound dehydration, electrolyte abnormalities, refractory hypotension, and low cortisol levels, which responded favorably to prompt hydrocortisone administration. The case highlights the importance of a high index of suspicion in patients presenting with unexplained shock and seizures, particularly when standard treatments fail and laboratory abnormalities are present. The discussion explores the pathophysiological connection between stress hormones, the hypothalamic-pituitary-adrenal axis, and neuronal excitability, illustrating how dysregulation can predispose to seizures. It emphasizes the need for immediate endocrine intervention, airway protection, broad-spectrum antibiotics when infection is suspected, and comprehensive patient education to prevent recurrence. This report advocates for multidisciplinary collaboration in managing adrenal crisis and stresses the vital role of early glucocorticoid therapy to reduce mortality. Educating patients on sick-day management and ensuring access to emergency medications are crucial for effective prevention. Overall, recognizing adrenal crisis as a reversible cause of seizure and shock is paramount for improving outcomes and reducing associated morbidity and mortality.</p>","PeriodicalId":15460,"journal":{"name":"Journal of Community Hospital Internal Medicine Perspectives","volume":"16 3","pages":"19-22"},"PeriodicalIF":0.6,"publicationDate":"2026-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13492997/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148793806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hyperkalemia in Severe Burn Injuries: Pathogenesis and Therapeutic Advances.","authors":"Ting He","doi":"10.55729/2000-9666.1595","DOIUrl":"https://doi.org/10.55729/2000-9666.1595","url":null,"abstract":"<p><p>Hyperkalemia represents a prevalent and life-threatening complication in critically ill burn patients, presenting a significant threat to clinical outcomes and mortality rates. This review provides a comprehensive analysis of the multifactorial pathogenesis underlying hyperkalemia in this population. Furthermore, we critically evaluate recent therapeutic advances, including novel pharmacological interventions, and optimized dialysis protocols. Through synthesizing current evidence from clinical trials and pathophysiological studies, this work offers evidence-based recommendations for optimized clinical management while identifying critical knowledge gaps requiring further investigation. Enhanced understanding of these mechanisms and therapeutic modalities is paramount for developing targeted treatments that improve survival and reduce morbidity in severe burn injuries.</p>","PeriodicalId":15460,"journal":{"name":"Journal of Community Hospital Internal Medicine Perspectives","volume":"16 3","pages":"27-33"},"PeriodicalIF":0.6,"publicationDate":"2026-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13493005/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148793816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}