{"title":"Beyond Atrial Fibrillation and Heart Failure: Ibrutinib-induced Pericardial Effusion.","authors":"Anaiya Singh, Kathryn Rucktuhl, Viraj Panchal, Poornima Ramadas","doi":"10.55729/2000-9666.1509","DOIUrl":"10.55729/2000-9666.1509","url":null,"abstract":"<p><p>Ibrutinib, a Bruton's tyrosine kinase inhibitor, has transformed the management of various hematological malignancies. However, its association with cardiovascular toxicities, particularly atrial fibrillation (AF), hypertension, and heart failure (HF), has raised clinical concerns. Pericardial effusion, though rare, is an emerging complication warranting attention. We present the case of a 62-year-old male with lymphoplasmacytic lymphoma, initially treated with Bendamustine and Rituximab, which was discontinued due to significant neutropenia. Ibrutinib therapy was initiated, leading to a partial response at three months. Approximately ten months into ibrutinib treatment, the patient developed new-onset dyspnea, palpitations, and dizziness. ECG revealed AF with rapid ventricular response, and transthoracic echocardiogram (TTE) showed a reduced left ventricular ejection fraction of 40 % and a moderate pericardial effusion. Baseline assessments prior to ibrutinib had indicated normal cardiac function. Given the development of heart failure with reduced ejection fraction and pericardial effusion, ibrutinib was discontinued. The patient was initiated on guideline-directed medical therapy for heart failure. Over six months, the patient exhibited significant cardiac recovery, with normalization of ejection fraction and resolution of the pericardial effusion. While atrial fibrillation and heart failure are recognized as adverse effects of ibrutinib, pericardial effusion is less commonly reported. Given the increasing use of ibrutinib, clinicians should maintain vigilance for cardiovascular complications. Early recognition and management are crucial to mitigate morbidity and mortality associated with these adverse effects. This case highlights the importance of comprehensive cardiovascular monitoring in patients receiving ibrutinib and contributes to the growing body of literature on its cardiotoxic profile.</p>","PeriodicalId":15460,"journal":{"name":"Journal of Community Hospital Internal Medicine Perspectives","volume":"15 4","pages":"81-87"},"PeriodicalIF":0.6,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12315882/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144775528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Anish K Shrestha, Sakthi Gautham, Shiavax J Rao, Khalid K Al-Talib, Sriram Padmanabhan
{"title":"Intradialytic Atrial Fibrillation With Rapid Ventricular Response From Catheter-related Right Atrial Thrombus.","authors":"Anish K Shrestha, Sakthi Gautham, Shiavax J Rao, Khalid K Al-Talib, Sriram Padmanabhan","doi":"10.55729/2000-9666.1490","DOIUrl":"10.55729/2000-9666.1490","url":null,"abstract":"<p><p>Right atrial thrombus is a rare complication of hemodialysis catheter with an incidence of <6 %. New-onset atrial fibrillation can be the first symptom of catheter-related right atrial thrombus (CRAT) in a patient with long-term dialysis catheter. Therefore, evaluation for CRAT is justified in such scenario. We highlight a case report where a new-onset atrial fibrillation led to the discovery of a right atrial thrombus in a patient with long-term dialysis catheter.</p>","PeriodicalId":15460,"journal":{"name":"Journal of Community Hospital Internal Medicine Perspectives","volume":"15 4","pages":"54-57"},"PeriodicalIF":0.6,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12315892/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144775535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Maha Zafar, Reshly M Rajan, Manaswini Krishnakumar, Aswanth Reddy
{"title":"Late Onset Malignant Metastatic Transformation of Benign Pheochromocytoma.","authors":"Maha Zafar, Reshly M Rajan, Manaswini Krishnakumar, Aswanth Reddy","doi":"10.55729/2000-9666.1515","DOIUrl":"10.55729/2000-9666.1515","url":null,"abstract":"<p><p>Pheochromocytomas and paragangliomas (PPGLs) are rare neuroendocrine tumors arising from adrenal medulla and extra-adrenal paraganglia. Metastatic pheochromocytomas, pose diagnostic and therapeutic challenges due to their atypical presentations and potential for malignant transformation years after primary tumor resection. We report a case of 61-year-old woman who presented with intermittent cough, shortness of breath, and elevated blood pressure 6 years after resection of primary adrenal pheochromocytoma. Imaging revealed bilateral pulmonary nodules, a retroperitoneal mass, and L4 vertebral involvement, raising suspicion for metastatic pheochromocytoma. Elevated serum meta-nephrines and normetanephrines, alongside tissue biopsy and MIBG imaging, confirmed diagnosis. Germline genetic testing did not reveal any pathogenic mutations. The patient underwent CT-guided cryoablation for retroperitoneal lymph nodes and scheduled for radiofrequency ablation (RFA) of metastatic lesions. This case underscores evolving understanding of PPGLs, challenging \"10 % rule\" regarding metastasis and inheritance. While mutations in genes such as SDHB are associated with increased metastatic risk, sporadic cases like this highlight need for lifelong surveillance in all patients' post-resection of primary tumor. Ablative techniques, EBRT, and emerging systemic therapies are promising methods for managing metastatic disease. This case highlights importance of long-term follow-up and genetic testing in patients with PPGLs, even in absence of hereditary mutations, to detect and manage late-onset metastatic disease efficiently.</p>","PeriodicalId":15460,"journal":{"name":"Journal of Community Hospital Internal Medicine Perspectives","volume":"15 4","pages":"92-95"},"PeriodicalIF":0.6,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12315872/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144775536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Blastomycosis in a Renal Transplant Recipient: A Rare Encounter in Rural Appalachia.","authors":"Khawaja O Omar, William Sebastian, Suzanne Kemper","doi":"10.55729/2000-9666.1470","DOIUrl":"10.55729/2000-9666.1470","url":null,"abstract":"<p><strong>Background: </strong>Blastomycosis is a fungal infection caused by <i>Blastomyces</i> species, which are thermally dimorphic fungi endemic to the midwestern, south-central, and southeastern United States (US). Organ transplant patients are at risk of infection due to long-term immunosuppressive therapy. We present a unique case of blastomycosis in a renal transplant patient residing in a non-endemic region of Appalachia.</p><p><strong>Case report: </strong>A 67-year-old patient with history of tobacco use, atrial fibrillation, type 2 diabetes, hyperlipidemia, and bilateral deceased donor kidney transplantation (DDKT) in 2021, presented to Charleston Area Medical Center's (CAMC), Charleston WV, Emergency Department (ED) for fever and night sweats. Initial workup revealed 39.4 °C temperature with remaining vital signs normal. Corona, parainfluenza, influenza, metapneumovirus, mycoplasma pneumonia, RSV were negative, GI PCR panel was negative for C. difficle, yersinia, campylobacter, giardia, vibrio, norovirus, salmonella, rotavirus. Chest X-ray showed a 2.1 × 1.6 cm nodular density in the left upper lobe (LUL) lobe. White blood cell (WBC) count was elevated at 13000/mcl with a left-sided shift. Subsequent computed tomography (CT) of the chest without contrast demonstrated a 2.7 × 2.1 cm LUL mass. Urine <i>Blastomyces</i> antigen tested positive, prompting the initiation of empiric therapy for blastomycosis. Aspergillus was ruled out initially.</p><p><strong>Conclusion: </strong>Blastomycosis is a rare occurrence in the US, with annual incidence reported at 1 to 2 cases per 100,000. While transplant recipients are predisposed to acquiring blastomycosis, it remains an infrequent occurrence. In transplant patients presenting with persistent infectious symptoms, blastomycosis and other rare etiologies should be considered to prevent severe complications.</p>","PeriodicalId":15460,"journal":{"name":"Journal of Community Hospital Internal Medicine Perspectives","volume":"15 4","pages":"96-99"},"PeriodicalIF":0.6,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12315875/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144775529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Fremita C Fredrick, Anish K R Meda, Mini Virmani, Guntash Kaur, Baltej Singh, Rohit Jain
{"title":"Hollywood and Healthcare: Navigating the Dual Impact of Movies on Public Health.","authors":"Fremita C Fredrick, Anish K R Meda, Mini Virmani, Guntash Kaur, Baltej Singh, Rohit Jain","doi":"10.55729/2000-9666.1495","DOIUrl":"10.55729/2000-9666.1495","url":null,"abstract":"<p><strong>Introduction: </strong>Synonymous with the American film industry, Hollywood wields considerable influence on public health through its vast global reach and engaging media. This paper explores Hollywood's role and its impacts on public health, primarily driven by its portrayal of healthcare services, illnesses, and related beliefs and provides recommendations to improve \"education entertainment\" for the future.</p><p><strong>Methods: </strong>PubMed was searched using keywords such as hollywood, healthcare, medical dramas, health education, smoking, suicide, and many more. Relevant literature up to June 2024 has been examined and summarized, which consisted of 37 articles with data from various clinical trials, meta-analyses, and literature reviews.</p><p><strong>Discussion: </strong>Medical dramas like \"Grey's Anatomy\" and \"E.R.\" have educated audiences on medical knowledge, healthcare structures, and inspired healthcare career aspirations. By depicting the realities of medical practice, these shows have enhanced public support for healthcare reforms. Similarly, films like \"Contagion\" have fostered awareness and empathy by positively portraying healthcare professionals during crises. However, Hollywood's glamorization of certain lifestyles has also contributed to body dissatisfaction and unhealthy behaviors, with increased cosmetic procedure rates and eating disorders linked to media portrayals. Furthermore, the depiction of smoking and vaping, as well as the sensationalized portrayal of suicides, has been shown to elevate risky behaviors and suicide rates among impressionable viewers.</p><p><strong>Conclusions: </strong>Hollywood's impact on healthcare is thus dual-faceted, necessitating responsible media practices and preventive measures to mitigate adverse outcomes while leveraging its potential for public health education.</p>","PeriodicalId":15460,"journal":{"name":"Journal of Community Hospital Internal Medicine Perspectives","volume":"15 3","pages":"23-29"},"PeriodicalIF":0.6,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12313283/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144775509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Rakahn Haddadin, Ozoemena Akah, Maryam Ameen, George Trad, John Ryan, Hatim Gemil
{"title":"It Runs in the Family: A Rare Case of Familial Idiopathic Colonic Varices.","authors":"Rakahn Haddadin, Ozoemena Akah, Maryam Ameen, George Trad, John Ryan, Hatim Gemil","doi":"10.55729/2000-9666.1473","DOIUrl":"10.55729/2000-9666.1473","url":null,"abstract":"<p><strong>Background: </strong>Colonic varices (CV) remain an extremely rare condition, the usual cause of which is portal hypertension due to liver disease, chronic pancreatitis or malignancy. Here we present a case of familial idiopathic CV in a middle-aged female, complicated by a polyp removal during colonoscopy.</p><p><strong>Case presentation: </strong>A 57-year-old female with a past medical history of 5 months of melena, polyps and hemorrhoids diagnosed with idiopathic CV during diagnostic colonoscopy. She had no prior history of liver disease, pancreatic disease, non-steroidal anti-inflammatory drugs (NSAID) use, or blood thinner use. She was later found to have a family history of the condition.</p><p><strong>Conclusion: </strong>The rarity of this case is of particular concern for clinicians due to its life threatening complication of severe lower gastrointestinal bleed - a true medical emergency. This is particularly difficult in the absence of usual predisposing triggers. Differential diagnoses should be considered in patients that present with rectal bleeding of unknown cause.</p>","PeriodicalId":15460,"journal":{"name":"Journal of Community Hospital Internal Medicine Perspectives","volume":"15 3","pages":"103-107"},"PeriodicalIF":0.6,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12313120/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144775514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Pneumococcal Endocarditis: Historical Insights and Modern Challenges.","authors":"Dmytro Bohuslavskyi, Mahesh Bhattarai, Hussam Ammar","doi":"10.55729/2000-9666.1493","DOIUrl":"10.55729/2000-9666.1493","url":null,"abstract":"<p><p>The patient in this case was a 72-year-old female who presented with altered mental status and was ultimately diagnosed with pneumococcal endocarditis. On physical examination, no abnormal cardiac murmurs were detected. This case highlights an important lesson: pneumococcal endocarditis, though rare, is a life-threatening condition with a high mortality rate and should be a top consideration in patients with S. pneumoniae bacteremia, even when the cardiac exam is relatively unremarkable.</p>","PeriodicalId":15460,"journal":{"name":"Journal of Community Hospital Internal Medicine Perspectives","volume":"15 3","pages":"80-83"},"PeriodicalIF":0.6,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12313118/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144775515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Eiraj Khan, Rimal Ilyas, Shivani Shah, Rahim Jiwani, Yazan Samhouri, Cyrus Khan
{"title":"A Rare Case of Chronic Lymphocytic Leukemia Complicated by Myasthenia Gravis.","authors":"Eiraj Khan, Rimal Ilyas, Shivani Shah, Rahim Jiwani, Yazan Samhouri, Cyrus Khan","doi":"10.55729/2000-9666.1494","DOIUrl":"10.55729/2000-9666.1494","url":null,"abstract":"<p><strong>Introduction: </strong>About 10-25 % of chronic lymphocytic leukemia (CLL) patients experience complications related to autoimmune activity. Although less common, non-hematological autoimmune manifestations have been observed. Myasthenia gravis (MG) is rarely found in association with CLL. Since 1967, only 27 publications have reported the association between CLL and MG, encompassing just 15 cases. Our case is particularly notable for the refractory nature of the patient's MG.</p><p><strong>Case presentation: </strong>A 56-year-old male with Rai Stage II CLL and myasthenia gravis presented to the emergency department with respiratory distress, dysphagia, and weakness. He was admitted for treatment with intravenous immune globulin, pyridostigmine, and intravenous solumedrol. Notably, the patient was diagnosed with CLL approximately three months prior and MG just one week before presentation. Despite aggressive treatment, the patient's myasthenia gravis symptoms persisted, prompting suspicion of CLL-related complications. Due to the patient's refractory myasthenia gravis, weekly rituximab 375 mg/m2 was initiated. He was given the first dose of rituximab during the hospital admission after which his dysphagia clinically improved.Outpatient management included obinutuzumab and Ventoclax for CLL control, resulting in gradual resolution of MG symptoms over a few months.</p><p><strong>Discussion: </strong>Patients with myasthenia gravis (MG) generally do not require routine leukemia screening unless factors such as lymphadenopathy, splenomegaly, or refractory MG warrant further evaluation. Conversely, symptoms like ptosis in chronic lymphocytic leukemia (CLL) should prompt MG assessment. Early CLL treatment, as seen in this case, can resolve neurological symptoms and achieve remission, highlighting the need for a timely diagnosis and intervention to enhance patient outcomes.</p>","PeriodicalId":15460,"journal":{"name":"Journal of Community Hospital Internal Medicine Perspectives","volume":"15 3","pages":"54-58"},"PeriodicalIF":0.6,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12313282/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144775500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Omer Usman, Abdullah Imtiaz, Muhammad A Basit, Maham Tariq, Rehaab Mujahid, Muhammad W Khan, Vishakh Prakash, Obaid U Rehman
{"title":"Diverticular Abscess and Percutaneous Drainage Outcomes: A Review of Clinical Practice for the Primary Team.","authors":"Omer Usman, Abdullah Imtiaz, Muhammad A Basit, Maham Tariq, Rehaab Mujahid, Muhammad W Khan, Vishakh Prakash, Obaid U Rehman","doi":"10.55729/2000-9666.1474","DOIUrl":"10.55729/2000-9666.1474","url":null,"abstract":"<p><p>The inflammation of the diverticular pouch is called acute diverticulitis which can result in abscess formations sometimes. Percutaneous drainage is routinely considered for the management of diverticular abscesses. Being a minimally invasive procedure employed for the removal of large collections of infected fluid from the abscesses, percutaneous drainage emerged as an appealing option. Historically, surgical removal of the abscesses has resulted in multiple hospitalizations and an increased burden on healthcare resources. With the advancement in radiological techniques, CT-guided percutaneous drainage of diverticular abscesses ensured enhanced patient satisfaction and reduced healthcare costs. The choice between surgery or percutaneous drainage of diverticular abscess remains a matter of debate among physicians. The outcomes of percutaneous drainage procedures are scattered across the literature. It is important to be familiar with the criteria regarding the choice of percutaneous drainage or colectomy during the management of diverticular abscesses. Percutaneous drainage can prevent emergent colectomy but it is not always a risk-free procedure. It can bring complications including persistent abscess, new onset abscess, abdominal wall abscess, and peritonitis. Therefore, a physician must prepare in advance to prevent these complications by selecting the right population for the procedure and ensuring good catheter care which involves readjusting the catheter, flushing the catheter and upgrading the size of the catheter. A physician not only prevents these complications but also effectively treats them. This review paper aims to summarize the important outcomes of percutaneous drainage of diverticular abscesses and their further management from a clinical standpoint.</p>","PeriodicalId":15460,"journal":{"name":"Journal of Community Hospital Internal Medicine Perspectives","volume":"15 3","pages":"30-37"},"PeriodicalIF":0.6,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12313123/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144775507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mustafa Shehzad, Muhammad Hasan, Dawood Shehzad, Muhammad S Akram, Muhammad F Akram, Dawlat Khan, Maham Maqsood, Mamoon Ahmed, Humna Younis
{"title":"Wild-type Cardiac Amyloidosis due to Transthyretin Protein - A Review.","authors":"Mustafa Shehzad, Muhammad Hasan, Dawood Shehzad, Muhammad S Akram, Muhammad F Akram, Dawlat Khan, Maham Maqsood, Mamoon Ahmed, Humna Younis","doi":"10.55729/2000-9666.1485","DOIUrl":"10.55729/2000-9666.1485","url":null,"abstract":"<p><p>Transthyretin amyloid cardiomyopathy (ATTR-CM) arises from the accumulation of transthyretin amyloid fibrils in the myocardium, a consequence of instability and misfolding in wild-type or variant transthyretin protein. ATTR-CM should be suspected in older heart failure patients with raised myocardial wall thickness and diastolic dysfunction on echocardiography in the absence of hypertension or other known causes. This diagnosis can be further supported with late gadolinium enhancement on Cardiac MRI which indicates raised myocardial extracellular volume (ECV) hinting at the expansion of interstitial space by amyloid deposits. Diagnostic work up starts with blood and urine tests to rule out AL amyloidosis and monoclonal gammopathy of undetermined significance (MGUS) followed up by nuclear scintigraphy with Tc-99m tracer which shows increased relative tracer uptake by the myocardium on Single-photon emission computed tomography (SPECT). Genetic testing of the transthyretin (TTR) gene determines wild or variant type of ATTR amyloidosis. Tafamidis, a TTR protein stabilizer, is currently the sole approved disease-modifying therapy for ATTR cardiomyopathy. Management of ATTR-CM also involves managing heart failure, arrhythmias, and heart blocks.</p>","PeriodicalId":15460,"journal":{"name":"Journal of Community Hospital Internal Medicine Perspectives","volume":"15 3","pages":"46-53"},"PeriodicalIF":0.6,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12313129/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144775520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}