Journal of Community Hospital Internal Medicine Perspectives最新文献

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Duodenal Perforation From Dislodged Prophylactic Pancreatic Stent Following ERCP for Hilar Cholangiocarcinoma: A Rare Adverse Event. 肝门胆管癌ERCP术后预防性胰腺支架移位致十二指肠穿孔:罕见的不良事件。
IF 0.6
Journal of Community Hospital Internal Medicine Perspectives Pub Date : 2026-07-17 eCollection Date: 2026-01-01 DOI: 10.55729/2000-9666.1610
Mina Alkomos, Jolie Ibrahim, Karan Desai, Beshoy E Elkomos, Walid Baddoura, Youssef Botros
{"title":"Duodenal Perforation From Dislodged Prophylactic Pancreatic Stent Following ERCP for Hilar Cholangiocarcinoma: A Rare Adverse Event.","authors":"Mina Alkomos, Jolie Ibrahim, Karan Desai, Beshoy E Elkomos, Walid Baddoura, Youssef Botros","doi":"10.55729/2000-9666.1610","DOIUrl":"10.55729/2000-9666.1610","url":null,"abstract":"<p><p>We report a rare complication of prophylactic pancreatic duct stenting during ERCP for suspected hilar cholangiocarcinoma. A 47-year-old woman presented with two weeks of painless jaundice, total bilirubin 18 mg/dL, and cholestatic enzymes. Imaging revealed intrahepatic biliary dilation without CBD dilation. ERCP with cholangioscopy identified a right hepatic duct stricture; biopsies were obtained. A 10 mm × 4 cm covered metal stent was placed in the CBD, a 7 Fr × 12 cm plastic stent in the right hepatic duct, and a 4 Fr × 5 cm pancreatic stent was prophylactically inserted after inadvertent duct cannulation. Two days later, she developed acute abdominal pain. CT revealed stent migration with duodenal perforation. Repeat ERCP removed the dislodged stent, closed the defect endoscopically, and replaced the metal biliary stent with plastic. Biopsies confirmed perihilar cholangiocarcinoma. This case emphasizes that although prophylactic stenting reduces the risk of post-ERCP pancreatitis, migration and perforation can occur, underscoring the importance of vigilance and early recognition of post-procedural complications.</p>","PeriodicalId":15460,"journal":{"name":"Journal of Community Hospital Internal Medicine Perspectives","volume":"16 4","pages":"147-150"},"PeriodicalIF":0.6,"publicationDate":"2026-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13532666/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148872904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Left-ventricular Non-compaction Cardiomyopathy Presenting With Atrial Flutter With Rapid Ventricular Response. 左心室非压实性心肌病表现为心房扑动伴心室快速反应。
IF 0.6
Journal of Community Hospital Internal Medicine Perspectives Pub Date : 2026-07-17 eCollection Date: 2026-01-01 DOI: 10.55729/2000-9666.1611
Sahil Ghay, Baneet Kaur, Juan A Talavera, Koushik Sanku, Viky S Loescher, Julien A Exposito
{"title":"Left-ventricular Non-compaction Cardiomyopathy Presenting With Atrial Flutter With Rapid Ventricular Response.","authors":"Sahil Ghay, Baneet Kaur, Juan A Talavera, Koushik Sanku, Viky S Loescher, Julien A Exposito","doi":"10.55729/2000-9666.1611","DOIUrl":"10.55729/2000-9666.1611","url":null,"abstract":"<p><p>Left ventricular non-compaction cardiomyopathy (LVNC) is a rare genetic cardiomyopathy characterized by prominent trabeculations and deep recesses that predispose to arrhythmias and heart failure. We describe a 42-year-old man with persistent tachycardia and exertional fatigue found to have CTI-dependent atrial flutter with 2:1 conduction. Transesophageal echocardiography showed severe biventricular dysfunction with an ejection fraction of 15%, and cardiac MRI confirmed LVNC with a non-compacted to compacted ratio of 3.3. After successful ablation and normal coronary angiography, he was diagnosed with LVNC. This case highlights an unusual presentation of LVNC with typical atrial flutter and underscores the value of cardiac MRI in diagnosing unexplained atrial arrhythmias.</p>","PeriodicalId":15460,"journal":{"name":"Journal of Community Hospital Internal Medicine Perspectives","volume":"16 4","pages":"138-142"},"PeriodicalIF":0.6,"publicationDate":"2026-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13496502/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148793748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Steroid-responsive Encephalopathy Associated with Autoimmune Thyroiditis: A Case Fulfilling Definite Graus Criteria. 类固醇反应性脑病与自身免疫性甲状腺炎:一例满足明确的格劳斯标准。
IF 0.6
Journal of Community Hospital Internal Medicine Perspectives Pub Date : 2026-07-17 eCollection Date: 2026-01-01 DOI: 10.55729/2000-9666.1618
Stephanie Ammari, Nawras Ibrahim, Sravani Karuchola, Samir Ouais
{"title":"Steroid-responsive Encephalopathy Associated with Autoimmune Thyroiditis: A Case Fulfilling Definite Graus Criteria.","authors":"Stephanie Ammari, Nawras Ibrahim, Sravani Karuchola, Samir Ouais","doi":"10.55729/2000-9666.1618","DOIUrl":"10.55729/2000-9666.1618","url":null,"abstract":"<p><p>Steroid-responsive encephalopathy associated with autoimmune thyroiditis (SREAT), also known as Hashimoto encephalopathy, is a rare immune-mediated neurological syndrome with an incidence of 2.1 per 100,000 and a 4:1 female predominance. Neurological manifestations are independent of thyroid status, occurring in 30-40% of euthyroid patients, and include cognitive impairment, confusion, seizures, and psychiatric symptoms. Diagnosis is challenging in the elderly, where symptoms overlap with dementia or delirium, with only 51 reported cases in patients aged ≥65 years. We describe a 70-year-old woman with autoimmune hypothyroidism and levothyroxine nonadherence who presented with progressive weakness, melena, dyspnea, and altered mental status complicated by obstructive uropathy, gastrointestinal bleeding, hypocalcemia, and severe hypothyroidism. Despite normalization of metabolic parameters and thyroid function, profound encephalopathy with fluctuating alertness, psychomotor slowing, memory impairment, psychosis, and a seizure-like episode persisted. Workup revealed elevated anti-thyroid antibodies, positive ANA, inflammatory CSF, diffuse EEG slowing, and low-titer GAD65 antibodies. High-dose prednisone led to dramatic improvement within 48 h, fulfilling adapted Graus criteria for definite SREAT. This case distinguishes SREAT from myxedema coma by the temporal dissociation between thyroid normalization and steroid response, emphasizes avoiding overinterpretation of low-titer GAD65 antibodies, and highlights CSF findings as supportive evidence. Early recognition is crucial in elderly patients with refractory encephalopathy and autoimmune thyroiditis.</p>","PeriodicalId":15460,"journal":{"name":"Journal of Community Hospital Internal Medicine Perspectives","volume":"16 4","pages":"115-119"},"PeriodicalIF":0.6,"publicationDate":"2026-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13496480/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148793781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Rare Presentation of Sequential Mucosa-Associated Lymphoid Tissue Lymphoma, Follicular Lymphoma, and Chronic Lymphocytic Leukemia: A Case-Based Review. 顺序性粘膜相关淋巴组织淋巴瘤、滤泡性淋巴瘤和慢性淋巴细胞白血病的罕见表现:一项基于病例的回顾。
IF 0.6
Journal of Community Hospital Internal Medicine Perspectives Pub Date : 2026-07-17 eCollection Date: 2026-01-01 DOI: 10.55729/2000-9666.1621
Khushi J Desai, Ansy H Patel, Patrick T O'Dowd, Joseph A Tworek, Preeti G Misra, Li Ding
{"title":"Rare Presentation of Sequential Mucosa-Associated Lymphoid Tissue Lymphoma, Follicular Lymphoma, and Chronic Lymphocytic Leukemia: A Case-Based Review.","authors":"Khushi J Desai, Ansy H Patel, Patrick T O'Dowd, Joseph A Tworek, Preeti G Misra, Li Ding","doi":"10.55729/2000-9666.1621","DOIUrl":"10.55729/2000-9666.1621","url":null,"abstract":"<p><strong>Introduction: </strong>Occurrence of 2 (or more) Hodgkin's and non-Hodgkin's lymphoma concordantly or sequentially in a single patient is very rare.</p><p><strong>Case: </strong>An 88-year-old Italian male with a history of mucosa-associated lymphoid tissue (MALT) lymphoma in remission and indolent follicular lymphoma under surveillance, presented with acute autoimmune hemolytic anemia (AIHA). While initially speculated to be secondary to follicular lymphoma relapse, stable mesenteric lymphadenopathy compared to prior CT abdomen/pelvis and smudge cells on peripheral smear prompted further evaluation. Peripheral blood flow cytometry indicated a mature B-cell neoplasm, which was confirmed to be chronic lymphocytic leukemia (CLL) with a bone marrow biopsy. Minimal improvement was observed with high-dose steroids, IV immunoglobulin, and rituximab therapy, ultimately leading to hospice care.</p><p><strong>Discussion: </strong>A population-based cancer registry study calculated the prevalence of sequential or composite lymphomas to be only 0.44%. Their occurrence can be explained by the common precursor cells hypothesis, chronic antigenic stimulation, and microenvironmental dependence. Possibly shared fundamental genetic alterations and acquired distinct secondary events lead to divergent clonal evolution. Limited data are available on the incidence of sequential lymphomas, and our case emphasizes the need for large, multicentric studies to stratify their risk factors, clinical implications, and suspicion index.</p>","PeriodicalId":15460,"journal":{"name":"Journal of Community Hospital Internal Medicine Perspectives","volume":"16 4","pages":"159-167"},"PeriodicalIF":0.6,"publicationDate":"2026-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13496473/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148793797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Tight Squeeze - Cardiac Tamponade in a Scleroderma Patient. 硬皮病患者的紧挤压-心脏填塞。
IF 0.6
Journal of Community Hospital Internal Medicine Perspectives Pub Date : 2026-07-17 eCollection Date: 2026-01-01 DOI: 10.55729/2000-9666.1608
Ifrah Nadeem, Charles E Geringer
{"title":"A Tight Squeeze - Cardiac Tamponade in a Scleroderma Patient.","authors":"Ifrah Nadeem, Charles E Geringer","doi":"10.55729/2000-9666.1608","DOIUrl":"10.55729/2000-9666.1608","url":null,"abstract":"<p><p>Systemic Sclerosis (SSc) is an autoimmune connective tissue disease marked by multiorgan fibrosis, including cutaneous involvement, and vasculopathy. Primary heart involvement in systemic sclerosis (SSc-pHI) includes heart failure, arrhythmia, pericarditis, pericardial effusion, valve disorders, and myocarditis. SSc-pHI remains a leading cause of mortality in this population. Pericardial effusion in SSc is usually associated with heart failure, pulmonary hypertension, and end-stage kidney disease. Cardiac tamponade is a rare initial presentation of SSc-pHI but carries a worse prognosis. Diagnosis is often challenging due to subclinical manifestations and requires advanced imaging modalities such as transthoracic echocardiography with tissue doppler and cardiac magnetic resonance imaging. Further research is necessary to elucidate pathogenic mechanisms and identify biomarkers essential for targeted therapy and improved clinical recommendations for this subgroup. This report presents a patient with SSc who presented with cardiac tamponade leading to cardiac arrest.</p>","PeriodicalId":15460,"journal":{"name":"Journal of Community Hospital Internal Medicine Perspectives","volume":"16 4","pages":"100-104"},"PeriodicalIF":0.6,"publicationDate":"2026-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13496494/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148793681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Case of Nivolumab-Induced Bullous Pemphigoid-Successfully Treated with Rituximab. 利妥昔单抗成功治疗尼伏单抗致大疱性类天疱疮1例。
IF 0.6
Journal of Community Hospital Internal Medicine Perspectives Pub Date : 2026-07-17 eCollection Date: 2026-01-01 DOI: 10.55729/2000-9666.1613
Rawa Amin, Neel Ranpura, Haris Hatic
{"title":"A Case of Nivolumab-Induced Bullous Pemphigoid-Successfully Treated with Rituximab.","authors":"Rawa Amin, Neel Ranpura, Haris Hatic","doi":"10.55729/2000-9666.1613","DOIUrl":"10.55729/2000-9666.1613","url":null,"abstract":"<p><p>Drug-associated bullous pemphigoid (DABP) refers to cases of bullous pemphigoid caused by exposure to various drugs. We present a case of nivolumab (a programmed cell death-ligand 1 (PD-L1) inhibitor) induced bullous pemphigoid in a patient treated for classic Hodgkin's lymphoma, presenting four months after cessation of therapy. The patient demonstrated minimal clinical response to steroids and methotrexate. Following initiation of rituximab, the patient experienced rapid improvement of the rash with no further disease progression.</p>","PeriodicalId":15460,"journal":{"name":"Journal of Community Hospital Internal Medicine Perspectives","volume":"16 4","pages":"147-150"},"PeriodicalIF":0.6,"publicationDate":"2026-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13496475/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148793696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Rectal Dieulafoy Lesion with Severe Hematochezia in a Warfarin-Treated Patient. 1例使用华法林治疗的患者伴严重便血的直肠尿潴留病变。
IF 0.6
Journal of Community Hospital Internal Medicine Perspectives Pub Date : 2026-07-17 eCollection Date: 2026-01-01 DOI: 10.55729/2000-9666.1625
Carlos Elizondo Alatorre, Maria G Rubianes Guerrero, Julio C Valencia Manrique, Jennifer Harley
{"title":"Rectal Dieulafoy Lesion with Severe Hematochezia in a Warfarin-Treated Patient.","authors":"Carlos Elizondo Alatorre, Maria G Rubianes Guerrero, Julio C Valencia Manrique, Jennifer Harley","doi":"10.55729/2000-9666.1625","DOIUrl":"10.55729/2000-9666.1625","url":null,"abstract":"<p><p>Dieulafoy lesions (DLs) are rare vascular malformations in the gastrointestinal tract that often present with gastrointestinal bleeding, most commonly in the stomach. Rectal DLs are exceptionally rare, representing less than 2% of cases. Warfarin use increases the risk for bleeding and management represents a challenge. We present a case of a 60-year-old male on chronic warfarin therapy who presented with severe hematochezia due to a rectal DL, requiring more than one colonoscopy and prothrombin complex concentrate (PCC) administration. While guidelines recommend PCC over fresh frozen plasma (FFP), they acknowledge that this is based on very low certainty of evidence.</p>","PeriodicalId":15460,"journal":{"name":"Journal of Community Hospital Internal Medicine Perspectives","volume":"16 4","pages":"124-129"},"PeriodicalIF":0.6,"publicationDate":"2026-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13532662/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148873091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Progressive facial Swelling and Airway Symptoms Revealing a Deep Neck Abscess With Atypical Microbiology. 进行性面部肿胀和气道症状显示有非典型微生物的深颈部脓肿。
IF 0.6
Journal of Community Hospital Internal Medicine Perspectives Pub Date : 2026-07-17 eCollection Date: 2026-01-01 DOI: 10.55729/2000-9666.1616
Drew K Knight, Sulaiman Hakam, Arash Bakian, Ilya Fonarov
{"title":"Progressive facial Swelling and Airway Symptoms Revealing a Deep Neck Abscess With Atypical Microbiology.","authors":"Drew K Knight, Sulaiman Hakam, Arash Bakian, Ilya Fonarov","doi":"10.55729/2000-9666.1616","DOIUrl":"10.55729/2000-9666.1616","url":null,"abstract":"<p><p>Deep neck abscesses have become less common in the antibiotic era; yet, they still pose major risks of morbidity and mortality if not addressed appropriately. Their proximity to the upper respiratory tract and mediastinal structures further exacerbates this risk. We present the case of a 56-year-old man with a medical history of type 2 diabetes mellitus, who exhibited a two-month history of recurrent left-sided facial edema, pain, and dysphagia. Computed tomography imaging confirmed a substantial fluid collection extending from the submandibular region into the mid-cervical area, from which aspiration yielded 110 mL of purulent material. Cultures indicated <i>Cutibacterium acnes</i>, an unusual culprit of deep neck space infections. Additional cytological analysis identified atypical squamous cells, further complicating the diagnosis. This case emphasizes the need to evaluate atypical microorganisms in deep neck infections, especially in patients with comorbidities.</p>","PeriodicalId":15460,"journal":{"name":"Journal of Community Hospital Internal Medicine Perspectives","volume":"16 4","pages":"155-158"},"PeriodicalIF":0.6,"publicationDate":"2026-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13496492/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148793769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Adult-onset IgA Vasculitis Initially Attributed to a Cutaneous Drug Reaction and Diverticulitis. 成人发病IgA血管炎最初归因于皮肤药物反应和憩室炎。
IF 0.6
Journal of Community Hospital Internal Medicine Perspectives Pub Date : 2026-07-17 eCollection Date: 2026-01-01 DOI: 10.55729/2000-9666.1626
Leila C Tou, Catherine Grace P Hobayan, Shane Devine, Sarah Koraym
{"title":"Adult-onset IgA Vasculitis Initially Attributed to a Cutaneous Drug Reaction and Diverticulitis.","authors":"Leila C Tou, Catherine Grace P Hobayan, Shane Devine, Sarah Koraym","doi":"10.55729/2000-9666.1626","DOIUrl":"10.55729/2000-9666.1626","url":null,"abstract":"<p><p>Immunoglobulin A vasculitis (IgAV), formerly Henoch-Schönlein purpura, is a small-vessel vasculitis characterized by palpable purpura, arthralgias, gastrointestinal involvement, and renal disease. Although IgAV is common in children, adult-onset disease is rare and may be associated with more severe manifestations, particularly renal involvement. In adults, IgAV may be difficult to recognize because of overlap with more common gastrointestinal, infectious, or medication-related conditions. We present a case of adult-onset IgAV initially attributed to presumed diverticulitis and later to a drug eruption following antibiotic exposure. This case highlights diagnostic pitfalls and the importance of early recognition and renal surveillance.</p>","PeriodicalId":15460,"journal":{"name":"Journal of Community Hospital Internal Medicine Perspectives","volume":"16 4","pages":"168-171"},"PeriodicalIF":0.6,"publicationDate":"2026-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13496474/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148793666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Case of N-Methyl-D-Aspartate (NMDA) Autoimmune Encephalitis in a 34-Year-Old Man Thought to Have Schizophrenia. 34岁男性n -甲基- d -天冬氨酸(NMDA)自身免疫性脑炎1例被认为患有精神分裂症。
IF 0.6
Journal of Community Hospital Internal Medicine Perspectives Pub Date : 2026-07-17 eCollection Date: 2026-01-01 DOI: 10.55729/2000-9666.1630
Riyad Amin, Michael Wilson, Morgan Koontz, Khawaja Omar
{"title":"A Case of N-Methyl-D-Aspartate (NMDA) Autoimmune Encephalitis in a 34-Year-Old Man Thought to Have Schizophrenia.","authors":"Riyad Amin, Michael Wilson, Morgan Koontz, Khawaja Omar","doi":"10.55729/2000-9666.1630","DOIUrl":"10.55729/2000-9666.1630","url":null,"abstract":"<p><strong>Background: </strong>N-methyl-d-aspartate (NMDA) autoantibody encephalitis is a rare autoimmune condition affecting approximately 1.5 per million people per year [1]. It predominantly occurs in young women and is often associated with tumors, particularly teratomas [3]. The diagnosis is aided by testing cerebrospinal fluid (CSF) or serum for NMDA receptor antibodies along with careful evaluation of symptoms. Misdiagnosis is common, as its symptoms can mimic other more prevalent conditions, such as upper respiratory illnesses or psychiatric disorders like acute psychosis or schizophrenia.</p><p><strong>Case report: </strong>We present the case of a 34-year-old man who was initially incarcerated and subsequently developed decreased communication and mild agitation over several days, leading to his transfer to a psychiatric institute with a presumed diagnosis of schizophrenia. As his encephalopathy worsened over weeks, he exhibited catatonic symptoms and was referred to our facility for further evaluation after an unrevealing workup, including an initial lumbar puncture.Upon re-evaluation, a lumbar puncture was repeated with an autoimmune panel, returning positive for anti-NMDA antibodies, confirming the diagnosis. The patient was initially treated with steroids and plasma exchange, resulting in minimal improvement. He later received intravenous immunoglobulin (IVIG) and concomitant rituximab, leading to some functional improvement to a non-verbal but alert state.</p><p><strong>Conclusion: </strong>This case highlights the importance of considering rare autoimmune encephalitis' in patients presenting with worsening encephalopathy in the setting of a new psychiatric diagnosis, despite its rare nature.</p>","PeriodicalId":15460,"journal":{"name":"Journal of Community Hospital Internal Medicine Perspectives","volume":"16 4","pages":"94-99"},"PeriodicalIF":0.6,"publicationDate":"2026-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13496478/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148793717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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