{"title":"Rare Case of Idiopathic Thrombocytopenia Causing Retrobulbar Hemorrhage.","authors":"Khawaja O Omar, William Sebastian, Amna Anees","doi":"10.55729/2000-9666.1379","DOIUrl":"https://doi.org/10.55729/2000-9666.1379","url":null,"abstract":"<p><p>Immune thrombocytopenia purpura (ITP) is defined as a platelet count lower than 100 × 10ˆ9/L, in the absence of known abnormalities in white blood cells, normal hemoglobin with generalized purpuric rash: making it a diagnosis of exclusion.1-2 ITP is due to destruction of platelets in the spleen via autoantibodies, resulting in reduced platelet counts.3 Though rare, ITP is linked with spontaneous retrobulbar hemorrhage (SRH). If ITP is identified, prompt treatment is needed to prevent loss of vision. An 80-year-old non-smoking woman with a history of diabetes, hypertension, and alpha thalassemia minor presented with a one-day history of a right occipital lobe headache and right sided ocular dysfunction. Workup showed a very low platelet count of 35,000/mm<sup>3</sup>, and elevated D-Dimer at 12,485 ng/mL. MRI revealed a new hemorrhage in the retrobulbar area causing right-sided proptosis. MRA showed no arteriovenous shunting, and the right ophthalmic artery was patent. Therapy for seven days with cryoprecipitate, IVIG, and steroids was started, symptoms resolved, and patient was discharged. The relationship between ITP and non-traumatic sub-periosteal orbital hemorrhage (NTSOH) is unclear, but its occurrence in the setting of anemia is often seen. To best of our knowledge this is a rare case of NTSOH in a patient with mild anemia and acute ITP in the absence of other risk factors such as trauma or excessive Valsalva events.</p>","PeriodicalId":15460,"journal":{"name":"Journal of Community Hospital Internal Medicine Perspectives","volume":"14 5","pages":"124-127"},"PeriodicalIF":0.9,"publicationDate":"2024-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11466339/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142466631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ali Karim, Arisha M G Pathan, Allah Warayo, Iftikhar Ahmed, Aminullah Betanai, Fnu Dropati, Saqlain Ahmed, Pir R J Sarhandi, Poonam Kumari, Raveena B Bansari, Amin Mehmoodi, Jahanzeb Malik
{"title":"Intranasal Insulin for Treatment of Persistent Post-COVID-19 Olfactory Dysfunction: A Scoping Review.","authors":"Ali Karim, Arisha M G Pathan, Allah Warayo, Iftikhar Ahmed, Aminullah Betanai, Fnu Dropati, Saqlain Ahmed, Pir R J Sarhandi, Poonam Kumari, Raveena B Bansari, Amin Mehmoodi, Jahanzeb Malik","doi":"10.55729/2000-9666.1390","DOIUrl":"10.55729/2000-9666.1390","url":null,"abstract":"<p><p>Olfactory dysfunction has emerged as a prominent symptom of COVID-19, persisting in a subset of patients even after recovery. This scoping review aims to explore the potential of intranasal insulin as a treatment modality for persistent post-COVID-19 olfactory dysfunction. A comprehensive literature search was conducted to gather relevant studies examining the role of intranasal insulin in treating olfactory dysfunction, particularly in post-COVID-19 cases. Studies were included investigating intranasal insulin's mechanisms, efficacy, safety, and clinical outcomes. The review synthesizes findings from various studies suggesting the therapeutic potential of intranasal insulin in improving olfactory function. Research highlights the influence of intranasal insulin on neuroprotection, neurogenesis, and synaptic plasticity within the olfactory system, providing insights into its mechanisms of action. Furthermore, preliminary clinical evidence suggests improvements in olfactory sensitivity and intensity following intranasal insulin administration in post-COVID-19 patients with persistent olfactory dysfunction. While initial findings are encouraging, further rigorous investigations, including clinical trials with larger cohorts, are essential to validate these observations, ascertain optimal dosage regimens, and establish the safety and efficacy of intranasal insulin. This review provides a foundation for future research directions aimed at harnessing the therapeutic potential of intranasal insulin in addressing olfactory dysfunction following COVID-19.</p>","PeriodicalId":15460,"journal":{"name":"Journal of Community Hospital Internal Medicine Perspectives","volume":"14 5","pages":"55-62"},"PeriodicalIF":0.9,"publicationDate":"2024-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11466328/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142466628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Shaikh B Iqbal, Yakubu Bene-Alhasan, Shiavax J Rao
{"title":"Spontaneous Coronary Artery Dissection: A Case Series and Review of the Literature.","authors":"Shaikh B Iqbal, Yakubu Bene-Alhasan, Shiavax J Rao","doi":"10.55729/2000-9666.1355","DOIUrl":"10.55729/2000-9666.1355","url":null,"abstract":"<p><p>Although previously considered rare, spontaneous coronary artery dissection (SCAD) is increasingly recognized as an important cause of myocardial infarction in young women. We present three unique cases of SCAD: A 46-year-old woman with a history of trigeminal neuralgia and anxiety presenting elevated troponin-I and chest pain. A 36-year-old woman with recent miscarriage presenting with diffuse T wave inversions and elevated troponin-I. A 58-year-old man with a recent COVID-19 infection presenting with diffuse ST elevations. SCAD is associated with many risk factors. Conservative management is preferred due to spontaneous healing of vessels compared to PCI-driven management of atherosclerotic acute coronary syndrome.</p>","PeriodicalId":15460,"journal":{"name":"Journal of Community Hospital Internal Medicine Perspectives","volume":"14 4","pages":"42-48"},"PeriodicalIF":0.9,"publicationDate":"2024-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11464047/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142400431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Gastric Cancer: Clinical Features, Screening, Diagnosis, Treatment, and Prevention.","authors":"Rajarajeshwari Ramachandran, Tyler Grantham, Swetha Parvataneni, Deepa Budh, Sindhu Gollapalli, Madhavi Reddy, Vinaya Gaduputi","doi":"10.55729/2000-9666.1304","DOIUrl":"10.55729/2000-9666.1304","url":null,"abstract":"<p><p>The objective of this article is to highlight the clinical features, screening, diagnosis, treatment, and prevention of gastric cancer (GC). Early GC is often asymptomatic leading to frequent delays in diagnosis. Weight loss and persistent abdominal pain are the most common symptoms at initial diagnosis. The diagnosis of GC typically involves a combination of endoscopy, biopsy, and imaging studies. Endoscopic resection techniques are emerging as successful treatment options for early GC. Treatment options for advanced GC include surgery and chemotherapy. The first line chemotherapy for advanced GC consists of doublet therapy with a combination of platinum and fluoropyrimidines. Trastuzumab, a monoclonal antibody, is used in the treatment of human epidermal growth factor 2 positive GCs. Antiangiogenic agents and immunotherapy are also useful in the treatment of GC. Currently there are no GC screening guidelines in the United States, but they exist in other regions where there is increased prevalence of GC. Prevention strategies for GC include <i>Helicobacter pylori</i> eradication and adoption of a healthy diet consisting of fruits and vegetables.</p>","PeriodicalId":15460,"journal":{"name":"Journal of Community Hospital Internal Medicine Perspectives","volume":"14 2","pages":"49-57"},"PeriodicalIF":0.9,"publicationDate":"2024-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11221451/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141534557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Cases from a Community Hospital…JCHIMP Series #2: 66-Year-Old Man with Recurrent Painful Rashes and Oral Ulcerations","authors":"Fatima Halilu, Jing Wu, Joseph Fuscaldo, Nathan Dunsmore, Zain Syed, Pauline Daley","doi":"10.55729/2000-9666.1280","DOIUrl":"https://doi.org/10.55729/2000-9666.1280","url":null,"abstract":"","PeriodicalId":15460,"journal":{"name":"Journal of Community Hospital Internal Medicine Perspectives","volume":"3 4","pages":""},"PeriodicalIF":1.0,"publicationDate":"2024-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139440282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Azka Naeem, Kimberly Mae Soultan, Muhammad Hashim Khan, S. L. Vemula, Shaurya Sharma, Muzamil Naeem, Ravikaran Singh Patti
{"title":"A Case of Acupuncture Induced Pneumothorax","authors":"Azka Naeem, Kimberly Mae Soultan, Muhammad Hashim Khan, S. L. Vemula, Shaurya Sharma, Muzamil Naeem, Ravikaran Singh Patti","doi":"10.55729/2000-9666.1293","DOIUrl":"https://doi.org/10.55729/2000-9666.1293","url":null,"abstract":"","PeriodicalId":15460,"journal":{"name":"Journal of Community Hospital Internal Medicine Perspectives","volume":"8 12","pages":""},"PeriodicalIF":1.0,"publicationDate":"2024-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139439885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ezhilkugan Ganessane, S. Mahalingam, Selva Ganesan
{"title":"Non-ketotic hyperglycemia unmasks hemichorea - A reply","authors":"Ezhilkugan Ganessane, S. Mahalingam, Selva Ganesan","doi":"10.55729/2000-9666.1292","DOIUrl":"https://doi.org/10.55729/2000-9666.1292","url":null,"abstract":"","PeriodicalId":15460,"journal":{"name":"Journal of Community Hospital Internal Medicine Perspectives","volume":"14 2","pages":""},"PeriodicalIF":1.0,"publicationDate":"2024-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139439231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Severe Thrombocytopenia in Infective Endocarditis","authors":"Mayuri Patel, Biplov Adhikari, Amrit Devkota, Mahsa Mohebtash","doi":"10.55729/2000-9666.1272","DOIUrl":"https://doi.org/10.55729/2000-9666.1272","url":null,"abstract":"Thrombocytopenia can be seen in about 20-25% of patients with bacterial infective endocarditis (IE). Platelets have a major role in the pathogenesis of endocarditis, and they are also sensitive monitors of systemic host response to bacteremia. Thrombocytopenia on presentation of patients with IE identifies higher risk groups and carries higher mortality risk. The presence of thrombocytopenia is an independent prognosticator of poor outcomes in IE. We present a case of a 40-year-old male with the history of injection drug use who was diagnosed with IE and was found to have severe thrombocytopenia on admission was treated with intravenous antibiotics, which dramatically improved his platelet counts as well without any need for plasmapheresis or platelet transfusions.","PeriodicalId":15460,"journal":{"name":"Journal of Community Hospital Internal Medicine Perspectives","volume":"14 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135774766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Marlon Eliu Rivera Boadla, Azka Naeem, Sapna Kumari, Syed Mohammad Mazhar Uddin, Arafat Farooqui, Sanjay Maheshwari, Armando Seitllari, Zara Haq, Muhammad Hashim Khan, David J. Epstein, Sehajpreet Singh, Gerald Hollander, Kelash Kumar
{"title":"Third-Degree Heart Block in COVID-19 Pneumonia Complicated by Methicillin- Resistant Staphylococcus Aureus (MRSA) Bacteremia. A case report and review of literature","authors":"Marlon Eliu Rivera Boadla, Azka Naeem, Sapna Kumari, Syed Mohammad Mazhar Uddin, Arafat Farooqui, Sanjay Maheshwari, Armando Seitllari, Zara Haq, Muhammad Hashim Khan, David J. Epstein, Sehajpreet Singh, Gerald Hollander, Kelash Kumar","doi":"10.55729/2000-9666.1269","DOIUrl":"https://doi.org/10.55729/2000-9666.1269","url":null,"abstract":"Coronavirus disease 2019 (COVID-19) burden has been identified to cause multiorgan damage. Respiratory compromise is still one of the most common presentations, but cardiac injuries like myocardial injury, ischemia, and conduction abnormalities are also becoming prevalent. We present a case of an 87-year-old male with a history of dementia, type 2 diabetes mellitus, hypertension, chronic kidney disease, and a left kidney transplant hospitalized for respiratory distress and generalized tonic-clonic seizures. He was bradycardic to 27 beats per minute, hypotensive with mean arterial pressure(EKG) depicted a high-grade atrioventricular block (AV-block). The transvenous pacemaker was placed via femoral access and tested positive for COVID-19. Work-up was done to rule out possible causes of bradycardia, like hypothyroidism, ischemia, AV nodal blocking agents, and drug-induced bradycardia was negative. His hospital stay got complicated by methicillin-resistant staphylococcus aureus (MRSA) pneumonia leading to empyema and bacteremia. Unfortunately, being critically ill, the family opted for comfort measures, and he passed away. Our clinical vignette signifies cardiovascular complications in COVID-19 patients are associated with poor outcomes if not addressed. The conduction abnormalities in patients with intact cardiac structure and function are becoming more common in the setting of COVID infection. Assessment with serial EKGs and cardiac monitoring might be essential as patients can develop AV blocks at any point of the disease.","PeriodicalId":15460,"journal":{"name":"Journal of Community Hospital Internal Medicine Perspectives","volume":"11 6","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135774779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Biplov Adhikari, Robert Jones, Christopher James Haas
{"title":"Solid Pseudo-papillary Neoplasia: A Rare Malignancy of the Pancreas","authors":"Biplov Adhikari, Robert Jones, Christopher James Haas","doi":"10.55729/2000-9666.1254","DOIUrl":"https://doi.org/10.55729/2000-9666.1254","url":null,"abstract":"Solid pseudopapillary neoplasms (SPNs) are exceedingly rare type of exocrine pancreatic malignancy, representing only 0.9%-2.7% of all exocrine pancreatic malignancies. They predominantly affect young women and unlike other pancreatic malignancies, they have excellent prognoses with 5-year survival following surgical resection approaching 97%. Given the rarity of the disease, little is known about their histopathogenesis as they do not harbor similar genetic mutational abnormalities like other pancreatic tumors. We describe a rare case of SPN in a young female who was found to have the rare diagnosis during the work up for deranged liver function tests.","PeriodicalId":15460,"journal":{"name":"Journal of Community Hospital Internal Medicine Perspectives","volume":"9 4","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135775800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}