Journal of Community Hospital Internal Medicine Perspectives最新文献

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A Unique Metastatic Spread of Lung Adenocarcinoma to the Stomach: A Case Report and Literature Review. 一个独特的肺腺癌转移扩散到胃:一个病例报告和文献复习。
IF 0.6
Journal of Community Hospital Internal Medicine Perspectives Pub Date : 2025-11-14 eCollection Date: 2025-01-01 DOI: 10.55729/2000-9666.1547
Aniqa Faraz, Ammad Naeem, Hafiz M Aslam
{"title":"A Unique Metastatic Spread of Lung Adenocarcinoma to the Stomach: A Case Report and Literature Review.","authors":"Aniqa Faraz, Ammad Naeem, Hafiz M Aslam","doi":"10.55729/2000-9666.1547","DOIUrl":"10.55729/2000-9666.1547","url":null,"abstract":"<p><p>Lung cancer is a leading cause of cancer-related deaths and commonly spreads to the brain, bones, liver, and adrenal glands. Gastric metastases from lung cancer are uncommon and can occur in melanoma, breast cancer, and lung cancer. Most patients show no symptoms at presentation; however, metastasis from lung cancer portends a poor prognosis. This case report highlights a rare instance of lung cancer metastasizing to the stomach in a 60-year-old female that was detected incidentally on a PET scan. The scan showed two new stomach masses with increased FDG uptake and contrast enhancement. The patient had chemoimmunotherapy after receiving palliative radiotherapy to the stomach for gastric metastasis. Clinicians should maintain a high index of suspicion while monitoring gastrointestinal symptoms in patients with a history of lung cancer. Gastric metastases can sometimes mimic primary gastric malignancies on imaging/endoscopy, which can impact initial workup and delay correct diagnosis.</p>","PeriodicalId":15460,"journal":{"name":"Journal of Community Hospital Internal Medicine Perspectives","volume":"15 6","pages":"40-44"},"PeriodicalIF":0.6,"publicationDate":"2025-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12880931/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146142566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ileal Diverticulitis Leading to Small Bowel Obstruction: A Rare Case of Ileal diverticular Disease. 回肠憩室炎致小肠梗阻:一例罕见的回肠憩室病。
IF 0.6
Journal of Community Hospital Internal Medicine Perspectives Pub Date : 2025-09-12 eCollection Date: 2025-01-01 DOI: 10.55729/2000-9666.1522
Immanuel R Tullimalli, Vishnu S R Palyam, Srinath R Allala, Nabil Badro, Sumanth K Bandaru
{"title":"Ileal Diverticulitis Leading to Small Bowel Obstruction: A Rare Case of Ileal diverticular Disease.","authors":"Immanuel R Tullimalli, Vishnu S R Palyam, Srinath R Allala, Nabil Badro, Sumanth K Bandaru","doi":"10.55729/2000-9666.1522","DOIUrl":"10.55729/2000-9666.1522","url":null,"abstract":"<p><p>While small bowel diverticulosis, particularly, ileal diverticulitis is rare and often asymptomatic, it can lead to chronic vague symptoms or acute complications. Acute presentations may mimic appendicitis, small bowel obstruction, or colonic diverticulitis but can also appear with atypical symptoms, making diagnosis challenging. In many cases, definitive diagnosis relies on imaging such as abdominal CT, which can identify features like extraluminal air or mass lesions, though surgical exploration may be required in complex cases. Small bowel diverticula are structural outpouchings of the intestinal wall, typically located on the mesenteric border, and are more common in men with a male-to-female ratio of 2:1. They are predominantly found in the proximal jejunum (75 %), followed by the distal jejunum (20 %) and ileum (5 %). Complications such as obstruction, perforation, and localized peritonitis may occur, necessitating prompt surgical intervention. Management of uncomplicated cases typically involves bowel rest, intravenous fluids, and antibiotics. For complicated cases, resection of the affected bowel segment with primary anastomosis is the treatment of choice. Early recognition and timely surgical intervention are crucial to preventing severe morbidity and mortality associated with this rare condition.</p>","PeriodicalId":15460,"journal":{"name":"Journal of Community Hospital Internal Medicine Perspectives","volume":"15 5","pages":"90-93"},"PeriodicalIF":0.6,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12959097/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147365245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Elevated Creatine Kinase as a Marker for Aggressive GI Malignancy. 肌酸激酶升高作为侵袭性胃肠道恶性肿瘤的标志物。
IF 0.6
Journal of Community Hospital Internal Medicine Perspectives Pub Date : 2025-09-12 eCollection Date: 2025-01-01 DOI: 10.55729/2000-9666.1544
Ramya Vasireddy, Joseph Atarere, Jeffrey Iding, Abhinav Sankineni
{"title":"Elevated Creatine Kinase as a Marker for Aggressive GI Malignancy.","authors":"Ramya Vasireddy, Joseph Atarere, Jeffrey Iding, Abhinav Sankineni","doi":"10.55729/2000-9666.1544","DOIUrl":"10.55729/2000-9666.1544","url":null,"abstract":"<p><p>Klatskin tumor is a rare and aggressive biliary malignancy with a poor prognosis. We present a 72-year-old male with a history of COPD and severe non-ischemic cardiomyopathy who presented with jaundice, pruritus, and fatigue. Laboratory findings revealed marked hyperbilirubinemia and elevated liver enzymes, along with significantly increased creatine kinase (CK). Imaging studies and ERCP confirmed the diagnosis of perihilar cholangiocarcinoma, Bismuth class III, with adenocarcinoma pathology. Despite palliative stent placement, the patient's bilirubin levels remained elevated, and CK peaked at 45,000 units/L. Due to his advanced disease and comorbidities, he was not a candidate for surgical or systemic therapy and was transitioned to home hospice. This case highlights the diagnostic and therapeutic challenges in managing Klatskin tumors and the importance of recognizing significant elevation in CK, which in the absence of signs of muscle breakdown/pain may hypothetically correlate with aggressive forms of gastrointestinal malignancies.</p>","PeriodicalId":15460,"journal":{"name":"Journal of Community Hospital Internal Medicine Perspectives","volume":"15 5","pages":"104-107"},"PeriodicalIF":0.6,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12959106/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147365242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Thyrotoxicosis Triggering Takotsubo Cardiomyopathy and Acute Coronary Syndrome: A Case of Severe Cardiovascular Manifestations in Hyperthyroidism. 甲状腺毒症引发Takotsubo心肌病和急性冠状动脉综合征:甲亢严重心血管症状1例。
IF 0.6
Journal of Community Hospital Internal Medicine Perspectives Pub Date : 2025-09-12 eCollection Date: 2025-01-01 DOI: 10.55729/2000-9666.1527
Raiyan Ali, Nathaniel Lin, Taha Siddiqui, Mohit Sharma
{"title":"Thyrotoxicosis Triggering Takotsubo Cardiomyopathy and Acute Coronary Syndrome: A Case of Severe Cardiovascular Manifestations in Hyperthyroidism.","authors":"Raiyan Ali, Nathaniel Lin, Taha Siddiqui, Mohit Sharma","doi":"10.55729/2000-9666.1527","DOIUrl":"10.55729/2000-9666.1527","url":null,"abstract":"<p><p>Hyperthyroidism can lead to serious cardiovascular complications, including arrhythmias, high-output heart failure, and myocardial ischemia. Thyrotoxicosis, a hypermetabolic emergency, may mimic or exacerbate acute coronary syndrome (ACS) and, though rare, has been associated with takotsubo cardiomyopathy. We present a case of a 54-year-old thyrotoxic female without significant cardiovascular history who presented with atypical chest pain complicated by both takotsubo cardiomyopathy and myocardial infarction. This case not only emphasizes the diagnostic challenge posed by thyroid-induced cardiac dysfunctions but also highlights the importance of multidisciplinary management in these patients.</p>","PeriodicalId":15460,"journal":{"name":"Journal of Community Hospital Internal Medicine Perspectives","volume":"15 5","pages":"45-49"},"PeriodicalIF":0.6,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12959115/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147365344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Severe Hyponatremia Presenting With Mild Symptoms and Multifactorial Etiology. 重度低钠血症症状轻,病因多因素。
IF 0.6
Journal of Community Hospital Internal Medicine Perspectives Pub Date : 2025-09-12 eCollection Date: 2025-01-01 DOI: 10.55729/2000-9666.1540
Nathaniel Lin, Muhammad Cheema, Usman Fahim, Abdullah Ali, Andrew Weber
{"title":"Severe Hyponatremia Presenting With Mild Symptoms and Multifactorial Etiology.","authors":"Nathaniel Lin, Muhammad Cheema, Usman Fahim, Abdullah Ali, Andrew Weber","doi":"10.55729/2000-9666.1540","DOIUrl":"10.55729/2000-9666.1540","url":null,"abstract":"<p><p>Hyponatremia is a common electrolyte disturbance; however, serum sodium level of 99 mEq/L without severe symptoms or known duration is rare and noteworthy. We report a case of an 87-year-old female who presented with fatigue, decreased appetite, and mild emesis for the past 2 days in which blood work revealed a serum sodium level 99 mEq/L. The etiology of hyponatremia in an elderly patient may be complex due to higher likelihood of co-morbid medical conditions. Additionally, syndrome of inappropriate antidiuretic hormone (SIADH) can pose a diagnostic challenge as fewer than 50 % of patients have typical lab results that confirm the diagnosis (Ewout, November 2009)1.</p>","PeriodicalId":15460,"journal":{"name":"Journal of Community Hospital Internal Medicine Perspectives","volume":"15 5","pages":"81-84"},"PeriodicalIF":0.6,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12959112/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147365290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Unveiling an Uncommon Complication: Pleural Effusion Secondary to Pioglitazone Use. 揭示一种罕见的并发症:吡格列酮使用后继发的胸腔积液。
IF 0.6
Journal of Community Hospital Internal Medicine Perspectives Pub Date : 2025-09-12 eCollection Date: 2025-01-01 DOI: 10.55729/2000-9666.1541
Ranjana Chimauriya, Abhinandan Chittal, Khalid Malik, Tiffany DuMont, Christopher J Haas
{"title":"Unveiling an Uncommon Complication: Pleural Effusion Secondary to Pioglitazone Use.","authors":"Ranjana Chimauriya, Abhinandan Chittal, Khalid Malik, Tiffany DuMont, Christopher J Haas","doi":"10.55729/2000-9666.1541","DOIUrl":"10.55729/2000-9666.1541","url":null,"abstract":"<p><p>Pioglitazone, a peroxisome proliferator-activated receptor gamma (PPAR-γ) agonist, is used in the treatment of Type 2 diabetes mellitus by reducing insulin resistance. While peripheral edema and fluid retention are well-documented adverse effects, isolated pleural effusion in the absence of heart failure is rare. We present the fourth reported case of a woman in her 60s with Type 2 diabetes who developed recurrent left-sided pleural effusion after the initiation and dose escalation of pioglitazone. The effusion resolved completely following discontinuation of the drug. This case underscores the importance of early recognition of drug-induced pleural effusion and timely cessation of the offending agent to prevent morbidity.</p>","PeriodicalId":15460,"journal":{"name":"Journal of Community Hospital Internal Medicine Perspectives","volume":"15 5","pages":"94-98"},"PeriodicalIF":0.6,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12959103/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147365312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Role of Addiction Medicine Consultation Service in a Community Hospital: Evaluation of the Novel Service. 社区医院成瘾药物咨询服务的作用:新型服务的评价
IF 0.6
Journal of Community Hospital Internal Medicine Perspectives Pub Date : 2025-09-12 eCollection Date: 2025-01-01 DOI: 10.55729/2000-9666.1535
Srikrishna V Malayala, Wesley C Perez, Rukshar Thapa, Archie Madan, Kushagar Singla, Pragyat Singh, Pelash Kumar, Akshay Thaper
{"title":"Role of Addiction Medicine Consultation Service in a Community Hospital: Evaluation of the Novel Service.","authors":"Srikrishna V Malayala, Wesley C Perez, Rukshar Thapa, Archie Madan, Kushagar Singla, Pragyat Singh, Pelash Kumar, Akshay Thaper","doi":"10.55729/2000-9666.1535","DOIUrl":"10.55729/2000-9666.1535","url":null,"abstract":"<p><strong>Objectives: </strong>Fewer than 2500 physicians nationwide are certified in addiction medicine. Inpatient addiction hospitalist services have been shown to improve patient outcomes, but their capabilities and impact are underexplored in community hospitals. This study evaluates the role of an addiction medicine hospitalist service in enhancing patient outcomes in two community-based hospitals.</p><p><strong>Methods: </strong>A retrospective chart review was conducted on patients who received care from addiction medicine service in two hospitals. The data were collected within the first 120 days of the establishment of service. The reason for consultation, substances used, types of management, impact on transition of care, readmissions and length of stay were evaluated.</p><p><strong>Results: </strong>152 patients were seen by the addiction medicine service during the study period. Majority of consultations came from internal medicine followed by general surgery, family medicine, burns and maternity. Ongoing substance use accounted for 47.7 % of consultations, 31.8 % for managing withdrawal, and 21.9 % for managing overdose and toxicity. Medications for alcohol use disorder were started in 87.5 % of cases and opioid use disorder in 96 %. Buprenorphine was the most commonly initiated medication for opioid use disorder and naltrexone for alcohol use disorder. In 14.7 % of cases, the service made a positive impact on length of stay. The readmission rate in these patients was 8.4 % as compared to 13 % for all the patients admitted to the hospital during the study period.</p><p><strong>Conclusions: </strong>Addiction medicine hospitalist service can offer quality care to a wide variety of SUDs in a community hospital setting and supports multiple services.</p>","PeriodicalId":15460,"journal":{"name":"Journal of Community Hospital Internal Medicine Perspectives","volume":"15 5","pages":"18-24"},"PeriodicalIF":0.6,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12959116/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147365364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Educational Development for New GME Programs at Community Hospitals: Process, Outcomes and Recommendations. 社区医院新GME项目的教育发展:过程、结果和建议。
IF 0.6
Journal of Community Hospital Internal Medicine Perspectives Pub Date : 2025-09-12 eCollection Date: 2025-01-01 DOI: 10.55729/2000-9666.1532
Ebun O Ebunlomo, Christine Ford, Kamilla Guinn, Lauren Irwin
{"title":"Educational Development for New GME Programs at Community Hospitals: Process, Outcomes and Recommendations.","authors":"Ebun O Ebunlomo, Christine Ford, Kamilla Guinn, Lauren Irwin","doi":"10.55729/2000-9666.1532","DOIUrl":"10.55729/2000-9666.1532","url":null,"abstract":"<p><strong>Introduction: </strong>Changes in the U.S. healthcare system have led to graduate medical education (GME) programs expanding beyond academic medical centers to community hospitals. Direct-care physicians at these hospitals are now responsible for supervising trainees, requiring them to develop new skills in education. This article describes how our educational development office collaborated with community hospital GME program directors to pilot faculty development programming to integrate community hospital physicians into trainee education.</p><p><strong>Methods: </strong>We met with program directors for two GME community programs, reviewed topics that would be most helpful to clinicians who are unfamiliar with education, and organized workshops to prepare them for their expanded role. Workshops were facilitated at the respective hospital locations and recorded for future reference. We administered surveys after each session and interviewed program directors to evaluate the workshops' impact.</p><p><strong>Results: </strong>Overall, we conducted a total of 14 one-hour workshops. Program director interview results showed buy-in from faculty members regarding learning how to be effective teachers. Faculty also expressed greater confidence in engaging with learners after the workshops. Some areas of improvement were increased awareness and promotion of session offerings and the integration of clinician co-presenters.</p><p><strong>Discussion: </strong>By engaging GME program directors at community hospitals in creating educational development programs for their faculty, we provided crucial support to build teaching capacity for direct-care physicians. This blueprint provides guidance for others to more quickly implement educational training for direct-care physicians and is relevant for other independent academic medical centers seeking ways to support their community hospitals with new GME programs.</p>","PeriodicalId":15460,"journal":{"name":"Journal of Community Hospital Internal Medicine Perspectives","volume":"15 5","pages":"1-5"},"PeriodicalIF":0.6,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12959110/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147365239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Impact of COVID-19 on Alcohol-related Morbidity and Mortality: A Multicenter Study. COVID-19对酒精相关发病率和死亡率的影响:一项多中心研究
IF 0.6
Journal of Community Hospital Internal Medicine Perspectives Pub Date : 2025-09-12 eCollection Date: 2025-01-01 DOI: 10.55729/2000-9666.1533
Abhinav K Rao, Erica Paulos, Nancy Crossley, Don C Rockey
{"title":"The Impact of COVID-19 on Alcohol-related Morbidity and Mortality: A Multicenter Study.","authors":"Abhinav K Rao, Erica Paulos, Nancy Crossley, Don C Rockey","doi":"10.55729/2000-9666.1533","DOIUrl":"10.55729/2000-9666.1533","url":null,"abstract":"<p><strong>Background: </strong>During the COVID-19 pandemic, there was a rise in alcohol (ethanol) use nationwide. In this study, we investigated the effect of COVID-19 on alcohol-related hospital outcomes.</p><p><strong>Methods: </strong>Deidentified claims data spanning 2018 through 2022 from HCA's Enterprise Data Warehouse (South Atlantic Division) were examined. The population included adults aged >18 years who had an encounter at an HCA facility and a diagnosis of alcohol use disorder or alcohol-related illnesses. Two time frames were evaluated: 2018-2019 (pre- COVID-19) and 2021-2022 (COVID-19). Statistical analyses were performed to evaluate LOS, home discharge, and mortality.</p><p><strong>Results: </strong>Of the 72,575 patients (26,678 during the COVID-19 time period and 35,897 from 2018 to 19) meeting inclusion criteria for alcohol use and alcohol-related illness, the majority were male, had an average age of 50-years-old, and were predominantly White. Among the 26,678 COVID-19 patient admissions (2021-2022), 12,735 (35 %) were diagnosed with COVID-19 (p < 0.001). During the COVID-19 period, there was a 36 % increase in mortality, 2 % fewer discharges home, and a half day increase in average LOS (vs pre-COVID-19 period; all p < 0.001). In multivariable regression, patients who tested positive for COVID-19 had a 3-day longer length of stay, a 60 % lower likelihood of discharge to home, and a 284 % higher inpatient mortality rate compared to COVID-negative patients (all p < 0.001).</p><p><strong>Conclusions: </strong>Patients diagnosed with COVID-19 and alcohol-related morbidity had longer LOS, fewer discharges home, and higher mortality. Together, the data suggest that COVID-19 is associated with increased morbidity in patients with an alcohol-related illness.</p>","PeriodicalId":15460,"journal":{"name":"Journal of Community Hospital Internal Medicine Perspectives","volume":"15 5","pages":"12-17"},"PeriodicalIF":0.6,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12959132/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147365356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Methotrexate Toxicity Management in Polymyalgia Rheumatica: A Case Report. 甲氨蝶呤对风湿性多肌痛的毒性管理:1例报告。
IF 0.6
Journal of Community Hospital Internal Medicine Perspectives Pub Date : 2025-09-12 eCollection Date: 2025-01-01 DOI: 10.55729/2000-9666.1531
Devi M Kotharu, Sai D Vutukuru, Prafullkumar Patel, Athmananda Nanjundappa, Sumanth K Bandaru
{"title":"Methotrexate Toxicity Management in Polymyalgia Rheumatica: A Case Report.","authors":"Devi M Kotharu, Sai D Vutukuru, Prafullkumar Patel, Athmananda Nanjundappa, Sumanth K Bandaru","doi":"10.55729/2000-9666.1531","DOIUrl":"10.55729/2000-9666.1531","url":null,"abstract":"<p><p>Methotrexate (MTX) is an anti-folate drug with anti-inflammatory and anti-proliferative properties. Low-dose methotrexate (10-25 mg/week) is widely recognized as a safe and effective treatment for various autoimmune disorders. While toxicity from low dose methotrexate is uncommon it can lead to severe complications like pancytopenia. We present a case of a 68-year-old male with a history of steroid-resistant Polymyalgia Rheumatica on methotrexate (20 mg weekly) and prednisone. He presented to the emergency room with oral mucosal lesions and reduced oral intake. Upon evaluation, he was found to have pancytopenia and transaminitis, raising concern for methotrexate toxicity. Treatment included folinic acid rescue therapy and filgrastim. This case highlights the importance of promptly identifying signs of methotrexate toxicity and regularly monitoring patients for adverse effects by healthcare providers.</p>","PeriodicalId":15460,"journal":{"name":"Journal of Community Hospital Internal Medicine Perspectives","volume":"15 5","pages":"60-63"},"PeriodicalIF":0.6,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12959108/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147365366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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