{"title":"Acute presentation of primary CNS lymphoma mimicking Toxoplasma in HIV infection","authors":"Indira Acharya, Scott R. DeBoer, Deepty Bhansali","doi":"10.55729/2000-9666.1251","DOIUrl":"https://doi.org/10.55729/2000-9666.1251","url":null,"abstract":"Primary CNS lymphoma (PCNSL) accounts for up to 15% of non-Hodgkin lymphomas in HIV patients and is the second most common cause of space-occupying brain lesions in HIV patients after CNS toxoplasmosis. Differentiation of PCNL and CNS toxoplasmosis is crucial as PCNL carries a poor prognosis with survival time of 2-4 months without treatment but can be improved with prompt initiation of chemotherapy. These two entities often present clinically in a similar manner, and conventional imaging can also be a diagnostic challenge due to overlapping imaging characteristics. Thus, definitive diagnosis of PCNSL relies on histopathologic confirmation. Here, we present a case of intracranial lesion that presented acutely in the context of headache and left sided body weakness and was found to have PCNSL","PeriodicalId":15460,"journal":{"name":"Journal of Community Hospital Internal Medicine Perspectives","volume":"10 2","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135775796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Darrell Downs, Keerthana Sivakolundu, Nica Lim, Manasa Kandula
{"title":"Valacyclovir as etiology for Drug Reaction with Eosinophilia and Systemic Symptoms: A Case Report","authors":"Darrell Downs, Keerthana Sivakolundu, Nica Lim, Manasa Kandula","doi":"10.55729/2000-9666.1248","DOIUrl":"https://doi.org/10.55729/2000-9666.1248","url":null,"abstract":"Background: Drug reaction with eosinophilia and systemic symptoms (DRESS) is a potentially life-threatening condition associated with variable clinical presentations including rash, fevers, eosinophilia, and visceral organ involvement. It is a hypersensitivity reaction, and most cases have an identifiable inciting factor of drug exposure. Case Presentation: We present an interesting case of DRESS syndrome in a 97-year-old patient after she was treated with valacyclovir for herpes zoster. Her presentation included an exanthematous rash, acute kidney injury and progression to development of mildly elevated liver enzymes. Skin biopsy was consistent with DRESS. Patient initially responded to steroids but had a relapse during steroid taper. She eventually responded well to a slow prolonged steroid taper and had complete resolution of organ dysfunction and skin manifestations. Conclusion: Valacyclovir is a rare but important cause of DRESS. A thorough history of the illness timeline and a high index of clinical suspicion is required for the prompt diagnosis and treatment of the condition. Apart from withdrawal of the offending agent, a slow prolonged taper of steroids is the current recommended treatment as rapid reduction of steroid dosage can lead to a relapse of cutaneous and systemic symptoms.","PeriodicalId":15460,"journal":{"name":"Journal of Community Hospital Internal Medicine Perspectives","volume":"9 2","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135775802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
TerechinOlga, JohansenPaul M, RosenAdam R, MorganMatthew, FraenkelLiana
{"title":"Mortality Rate Among Patients with Alcohol Use Disorder with Two or More Readmissions to the Hospital.","authors":"TerechinOlga, JohansenPaul M, RosenAdam R, MorganMatthew, FraenkelLiana","doi":"10.55729/2000-9666.1235","DOIUrl":"10.55729/2000-9666.1235","url":null,"abstract":"<p><strong>Background: </strong>Alcohol use disorder is associated with high morbidity and mortality rates, leading to a significant burden worldwide. Increased hazardous alcohol consumption has been reported during the COVID-19 pandemic raising concerns for greater impact of this already prevalent serious medical condition.</p><p><strong>Methods: </strong>We conducted chart reviews and described demographic and clinical data for patients with two or more hospital readmissions from June 2020 to July 2021 and followed survival status through June 2022.</p><p><strong>Results: </strong>We found a high mortality rate of 10.3%. Most patients had psychiatric conditions listed in the chart (n = 70, 80%). Only 34% (n = 24) of living patients and 6% (n = 1) of deceased patients were under psychiatric care. Rates of the utilization of medications for alcohol use disorder were low (n = 23, 26%).</p><p><strong>Interpretation: </strong>We found high mortality rates in patients with two or more hospital readmissions with low rates of utilization of medications for alcohol use disorder and psychiatric care, thus identifying areas of potential improvement.</p>","PeriodicalId":15460,"journal":{"name":"Journal of Community Hospital Internal Medicine Perspectives","volume":"13 1","pages":"90-93"},"PeriodicalIF":1.0,"publicationDate":"2023-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10589033/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70739162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Vidhyalakshmy Vivek, Sumeet Yadav, Hariprasad R Korsapati, Mikael Mir, Shika Jain, Abbas B Jama, Setu Trivedi, Qiping Xu, Namratha S Meda, Syed Ali, Anwar Khedr, Esraa Hassan, Noura Attallah, Harsha Patnaik, Sri U Jeevani Obulareddy, Ibtisam Rauf, Aishwarya R Korsapati, Salim Surani, Syed A Khan, Nitesh K Jain, Hasnain Bawaadam
{"title":"Coronary Artery Dissection and Myocarditis Caused by Eosinophilic Granulomatosis with Polyangiitis (EGPA): A Case Report.","authors":"Vidhyalakshmy Vivek, Sumeet Yadav, Hariprasad R Korsapati, Mikael Mir, Shika Jain, Abbas B Jama, Setu Trivedi, Qiping Xu, Namratha S Meda, Syed Ali, Anwar Khedr, Esraa Hassan, Noura Attallah, Harsha Patnaik, Sri U Jeevani Obulareddy, Ibtisam Rauf, Aishwarya R Korsapati, Salim Surani, Syed A Khan, Nitesh K Jain, Hasnain Bawaadam","doi":"10.55729/2000-9666.1219","DOIUrl":"10.55729/2000-9666.1219","url":null,"abstract":"<p><p>Eosinophilic granulomatosis with polyangiitis (EGPA) also referred to as Churg-Strauss syndrome is a rare vasculitis of the small to medium vessels. We present a rare case of acute coronary artery dissection brought on by EGPA, which generally has a poor prognosis. A 41-year-old male with history of bronchial asthma presented to the emergency room with a 2-week history of dyspnea, cough with clear phlegm, and fever. For the past eight months he had experienced episodes with similar symptoms relieved by steroids. CT chest showed bilateral upper lobe patchy opacities with extensive workup for infectious etiology being negative. He had peripheral eosinophilia with sinusitis. He had acute coronary syndrome and Coronary angiogram showed Right coronary artery dissection. After making a diagnosis of EGPA based on American college of Rheumatology criteria, he was successfully treated with high dose immunosuppression. Coronary artery dissection is a fatal and uncommon complication of EGPA which is usually diagnosed postmortem. Early recognition of this condition ante mortem and aggressive treatment can be lifesaving as demonstrated in our case.</p>","PeriodicalId":15460,"journal":{"name":"Journal of Community Hospital Internal Medicine Perspectives","volume":"1 1","pages":"50-56"},"PeriodicalIF":1.0,"publicationDate":"2023-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/3d/69/jchim-13-05-050.PMC10589049.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41576646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Covid- 19 Vaccine-induced Myocarditis.","authors":"MunjalJaskaran S, FloresSergio M, YousufHamza, GuptaVasu, MunjalRipudaman S, AnamikaFnu, MendparaVaidehi, ShahPriyanshi, JainRohit","doi":"10.55729/2000-9666.1229","DOIUrl":"10.55729/2000-9666.1229","url":null,"abstract":"<p><p>Myocarditis and pericarditis are rare adverse reactions, more commonly seen in young males after receiving the second dose of an mRNA vaccine. However, the benefits of vaccination heavily outweigh the risk of these side effects. In addition, vaccination boosters are effective against the newest, more infective variants. Therefore we expect more vaccines to be administered in the following years. The objective of this study is to review the current understanding of the mechanism, diagnosis, and treatment of myocarditis and pericarditis. Proposed mechanisms include molecular mimicry against the S protein and hypersensitivity reactions with mRNA vaccines and platelet aggregation and thrombus formation in cardiac blood vessels with adenoviral vaccines. Diagnosis of myocarditis is based on clinical findings, cardiac enzymes, ECG, MRI, and echocardiographic findings. Management includes NSAIDs and cardiovascular support in selected cases with ventricular dysfunction. Most patients have a mild presentation with preservation of cardiac function and recover entirely within seven days; the average hospital stay is three days. Long-term complications are infrequent.</p>","PeriodicalId":15460,"journal":{"name":"Journal of Community Hospital Internal Medicine Perspectives","volume":"13 1","pages":"44-49"},"PeriodicalIF":1.0,"publicationDate":"2023-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10589044/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70739073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Needle in a Haystack: Acute Intermittent Porphyria, an Often-missed Differential Diagnosis of Abdominal Pain.","authors":"Afoma Onyechi, Jessica Ohemeng-Dapaah, Winnie Shaba, Mosunmoluwa Oyenuga, Alexandre Lacasse, Sen Sandeep, Amar Jadhav, Vikas Kumar, Aditya Pante","doi":"10.55729/2000-9666.1232","DOIUrl":"10.55729/2000-9666.1232","url":null,"abstract":"<p><p>Acute intermittent porphyria (AIP) is a rare disease that arises due to deficiency of the biosynthetic enzyme porphobilinogen deaminase (PBGD) involved in heme synthesis. Acute attacks can present with abdominal pain and neurological symptoms, although vague in nature. Recurrent hospitalizations for idiopathic intermittent abdominal pain should warrant investigation for AIP. Posterior reversible encephalopathy (PRES) presents with visual disturbances and seizure-like activity and can be, although rarely, associated with AIP. It is noteworthy to know that antiepileptic medication used in management of PRES can in turn worsen AIP.</p>","PeriodicalId":15460,"journal":{"name":"Journal of Community Hospital Internal Medicine Perspectives","volume":"13 5","pages":"82-85"},"PeriodicalIF":1.0,"publicationDate":"2023-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/12/1c/jchim-13-05-082.PMC10589034.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49690767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Prevalence of Depression in Patients with Hematologic Diseases in Marrakesh, Morocco: A Single Center Experience.","authors":"Fatima Zahra Lahlimi, Oumaima Maghnouj, Khawla Khalil, Safaa Chaabane, Illias Tazi","doi":"10.55729/2000-9666.1220","DOIUrl":"10.55729/2000-9666.1220","url":null,"abstract":"<p><p>Depression in patients with cancer negatively influences their physical symptoms, treatment success, coping, and quality of life and is associated with increased mortality. The reported prevalence of emotional distress in patients followed in hematology varies widely across studies. This study investigated the prevalence of depression and explored the possible associated factors in patients followed in a hematological department.</p><p><strong>Methods: </strong>in this descriptive cross-sectional study of patients followed in the hematology department of the University Hospital Mohammed VI of Marrakesh between August 2020 and December 2020, depression symptoms were assessed using Mini International Neuropsychiatric Interview test and Beck Depression Inventory.</p><p><strong>Results: </strong>150 patients participated. Regarding their underlying pathology, 60% (90 patients) of patients were newly diagnosed with leukemia, and 8% patients were admitted for chronic anemia and 12% for lymphoma. Forty-eight percent of them had a characterized depressive episode. Four percent of these episodes were severe, 55% were moderate, and 41% were mild. Among all the factors, multivariate analysis showed that high prevalence of depression was associated with female gender and poor prognosis estimation by the patient.</p>","PeriodicalId":15460,"journal":{"name":"Journal of Community Hospital Internal Medicine Perspectives","volume":"13 5","pages":"34-38"},"PeriodicalIF":1.0,"publicationDate":"2023-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/06/60/jchim-13-05-034.PMC10589038.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49690769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Lessons From an MD PhD - From SLC13A5 to Neurology.","authors":"KopelJonathan, ClothierJeffrey","doi":"10.55729/2000-9666.1211","DOIUrl":"10.55729/2000-9666.1211","url":null,"abstract":"<p><p>The journey towards becoming a physician scientist is a long, arduous, and uncertain journey. Few medical students pursue a career as a physician scientist. Even those that do, the path towards maintaining a robust research career and clinical training can be difficult given the personal and social pressures to focus solely on research or clinical work. Despite the long history of science and medicine, there is question concerning the role that physician scientist in modern medicine. As a recent physician scientist graduate, physician scientists are greatly needed in the medical profession. The ability to overlap science, medicine, and the humanities together is an essential part of the producing a well-rounded and effective physician for a rapidly changing profession and world. Through my journey as a physician scientist in training, the lessons I've learned through my training in both the basic science and clinical portions can be helpful for medical students traversing both sides of the divide.</p>","PeriodicalId":15460,"journal":{"name":"Journal of Community Hospital Internal Medicine Perspectives","volume":"13 1","pages":"4-7"},"PeriodicalIF":1.0,"publicationDate":"2023-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10589030/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70738970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
David Philippides, Angelina Hong, Amanda Eukovich, Ali Chaudhry
{"title":"A Case of Grave's Thyrotoxicosis-Induced Takotsubo Cardiomyopathy Presenting with Cardiac Arrest After Winning the Lottery.","authors":"David Philippides, Angelina Hong, Amanda Eukovich, Ali Chaudhry","doi":"10.55729/2000-9666.1242","DOIUrl":"10.55729/2000-9666.1242","url":null,"abstract":"<p><p>Takotsubo syndrome (TTS) is a nonischemic cardiomyopathy with transient apical ballooning of the left ventricle and reduced ejection fraction that can be caused by severe emotional or physical stress, with diverse clinical presentations. This case describes a patient who went into cardiac arrest at a casino after winning the lottery. She was found to have Takotsubo cardiomyopathy, in the setting of uncontrolled hyperthyroidism. This is a very unique case of TTS presenting with cardiac arrest, and is also an uncommon example of TTS triggered by a positive rather than negative emotional life event.</p>","PeriodicalId":15460,"journal":{"name":"Journal of Community Hospital Internal Medicine Perspectives","volume":"13 5","pages":"97-100"},"PeriodicalIF":0.9,"publicationDate":"2023-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/de/77/jchim-13-05-097.PMC10589048.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49690760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Eosinophilia with Lung Involvement in an Elderly Patient with a History of Chronic Obstructive Pulmonary Disease.","authors":"Pitchaporn Yingchoncharoen, Jerapas Thongpiya, Mahmoud Abdelnabi, Natnicha Leelaviwat, Sakditad Saowapa, Kenneth Nugent","doi":"10.55729/2000-9666.1238","DOIUrl":"10.55729/2000-9666.1238","url":null,"abstract":"<p><p>Eosinophilia with pulmonary involvement is characterized by the presence of peripheral blood eosinophilia, typically >500 cells/mm3, nonspecific pulmonary symptoms, and radiographic evidence of pulmonary disease. Clinical, laboratory, and radiologic features can be overlapping in these diseases, thus, it is wise to approach eosinophilia with pulmonary involvement systematically to determine the diagnosis and provide definitive treatment for a better outcome. The authors present a case of idiopathic chronic eosinophilic pneumonia in a patient with a long history of chronic obstructive pulmonary disease (COPD) which was resolved by corticosteroid.</p>","PeriodicalId":15460,"journal":{"name":"Journal of Community Hospital Internal Medicine Perspectives","volume":"13 5","pages":"101-104"},"PeriodicalIF":1.0,"publicationDate":"2023-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/5f/13/jchim-13-05-101.PMC10589042.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49690763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}