Journal of Applied Biomaterials & Functional Materials最新文献

{"title":"The influence of polyimide MP-1™ wear particles on a rodent closed fracture healing model.","authors":"Rema A Oliver, Tian Wang, Chris Christou, Alisa Buchman, Simha Sibony, William R Walsh","doi":"10.1177/22808000241240296","DOIUrl":"10.1177/22808000241240296","url":null,"abstract":"<p><p>Joint replacements provide pain free movement for the injured or our aging population. Current prothesis mainly consist of hard metal on metal, or ceramic femoral head on ultra-high-molecular weight polyethylene (UHMWPE). In this study, a rodent fracture model was used to test the influence of wear debris from a high-performance polymer (polyimide MP-1™). Saline, MP-1™ Low Dose in Saline (1%), or MP-1 High Dose (2%) in Saline was injected directly into a standard closed unilateral femoral fracture in 12-week old Sprague Dawley rats (<i>n</i> = 25) for 1, 3 and 6 weeks. Endpoints included radiography, micro-computed tomography, mechanical testing and paraffin histology. No adverse effects from the wear particles were observed from the current study based on radiology, mechanical or histological data. Although the particles were present, histological analysis revealed a progression in healing between the Polyimide treated groups and the non-treated saline control groups over the duration of 1, 3, and 6 weeks, with no inhibition from the particles. The MP-1™ wear debris generated are larger than 1 µm thus are not able to be engulfed by macrophages and cause osteolysis. This family of polymers (polyimides) may be an ideal material to consider for articulating joints and other implants in the human body.</p>","PeriodicalId":14985,"journal":{"name":"Journal of Applied Biomaterials & Functional Materials","volume":"22 ","pages":"22808000241240296"},"PeriodicalIF":2.5,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140174841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of 5-fluorouracil/etoposide co-loaded electrospun nanofibrous scaffold for localized anti-melanoma therapy.","authors":"Shirin Shojaei, Mahtab Doostan, Hamidreza Mohammadi Motlagh, Seyedeh Sara Esnaashari, Hassan Maleki","doi":"10.1177/22808000241284439","DOIUrl":"https://doi.org/10.1177/22808000241284439","url":null,"abstract":"<p><p>Nanofibrous scaffolds have emerged as promising candidates for localized drug delivery systems in the treatment of cutaneous cancers. In this study, we prepared an electrospun nanofibrous scaffold incorporating 5-fluorouracil (5-FU) and etoposide (ETP) for chemotherapy targeting melanoma cutaneous cancer. The scaffold was composed of polyvinyl alcohol (PVA) and chitosan (CS), prepared via the electrospinning process and loaded with the chemotherapeutic agents. We conducted relevant physicochemical characterizations, assessed cytotoxicity, and evaluated apoptosis against melanoma A375 cells. The prepared 5-FU/ETP co-loaded PVA/CS scaffold exhibited nanofibers (NFs) with an average diameter of 321 ± 61 nm, defect-free and homogenous morphology. FTIR spectroscopy confirmed successful incorporation of chemotherapeutics into the scaffold. Additionally, the scaffold demonstrated a hydrophilic surface, proper mechanical strength, high porosity, and efficient liquid absorption capacity. Notably, sustained and controlled drug release was observed from the nanofibrous scaffold. Furthermore, the scaffold significantly increased cytotoxicity (95%) and apoptosis (74%) in A375 melanoma cells. Consequently, the prepared 5-FU/ETP co-loaded PVA/CS nanofibrous scaffold holds promise as a valuable system for localized eradication of cutaneous melanoma tumors and mitigation of adverse drug reactions associated with chemotherapy.</p>","PeriodicalId":14985,"journal":{"name":"Journal of Applied Biomaterials & Functional Materials","volume":"22 ","pages":"22808000241284439"},"PeriodicalIF":3.1,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142347139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The microstructure, composition, physical properties, and bioactivity of calcium silicate cement prototypes for vital pulp therapies.","authors":"Marina Vega-González, Rubén Abraham Domínguez-Pérez, Ana Edith Higareda-Mendoza, Ricardo Domínguez-Pérez, León Francisco Espinosa-Cristóbal, Roberto Gustavo Sánchez-Lara Y Tajonar","doi":"10.1177/22808000241296663","DOIUrl":"https://doi.org/10.1177/22808000241296663","url":null,"abstract":"<p><p>Hydraulic calcium silicate cements (HCSCs) are valuable for various dental procedures. However, several reports document inherent limitations and complaints about their high costs, hindering accessibility in low-and middle-income countries. This study aimed to characterize four low-cost HCSC prototypes to show their microstructure, composition, and fundamental physical properties. Four HCSC prototypes were formulated: 1- calcium silicate powder with 17.5 wt. % replacement of calcium tungstate, 2- calcium silicate powder with 17.5 wt. % replacement of zirconium oxide, 3- calcium silicate powder with 17.5 wt. % replacement of calcium tungstate and 2.5 wt. % of zirconium oxide and 4- calcium silicate powder with 10 wt. % replacement of calcium tungstate and 10 wt. % replacement of zirconium oxide. Scanning electron microscopy, energy-dispersive X-ray spectroscopy, and X-ray diffraction were used to assess their microstructure and composition. Additionally, radiopacity, setting time, solubility, pH, and in vitro bioactivity were evaluated at different time points and contrasted with controls (Mineral trioxide aggregate -MTA Angelus- and Intermediate restorative material -IRM-). Their production cost was significantly lower than commercially available HCSCs. All prototypes exhibited a microstructure and composition comparable to MTA Angelus. All the prototypes exhibited radiopacity exceeding 3 mm of aluminum and shorter initial and final setting times than MTA Angelus. The solubility of some prototypes closely adhered to the ISO standard recommendation of 3% after 1 day, and all promoted an alkaline pH and the formation of calcium/phosphate precipitates. These promising findings suggest the potential clinical application of these prototypes. However, further research is necessary to evaluate their mechanical and biological properties for definitive clinical use.</p>","PeriodicalId":14985,"journal":{"name":"Journal of Applied Biomaterials & Functional Materials","volume":"22 ","pages":"22808000241296663"},"PeriodicalIF":3.1,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142620794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Physical and mechanical properties assessment of glass ionomer cements modified with TiO₂ and Mg-doped hydroxyapatite nanoparticles.","authors":"Bojana Ramić, Milica Cvjetićanin, Branislav Bajkin, Milan Drobac, Marija Milanović, Dragan Rajnović, Veljko Krstonošić, Đorđe Veljović","doi":"10.1177/22808000241282184","DOIUrl":"https://doi.org/10.1177/22808000241282184","url":null,"abstract":"<p><p>High viscosity glass ionomer cements (GICs) are widely used in various clinical applications, being particularly effective in atraumatic restorative treatment (ART) due to the synergistic interaction between the material and the technique. However, the inadequate mechanical properties of GICs raise concerns regarding the predictability and longevity of these restorations in areas exposed to occlusal stress. Various modifications of the powder components have been proposed to improve the mechanical strength of GICs to withstand occlusal loading during mastication. In this in vitro study, we investigated whether the nanoparticles (NPs) added to commercially available GICs could fulfill this requirement, which would likely broaden the spectrum of their potential clinical applications. Two commercially available GIC powders (Fuji IX and Ketac Molar), modified by the addition of 5 wt.% TiO₂, MgHAp100 or MgHAp1000 NPs, were incorporated into the corresponding liquid in an appropriate ratio, and the mixed cements were evaluated in terms of fracture toughness, flexural strength, Vickers microhardness and rheological tests and compared with the original material. Fuji IX containing 5 wt.% MgHAp100 NPs had lower flexural strength, while Ketac Molar with 5 wt.% TiO₂ NPs showed increased fracture toughness. Vickers microhardness increased in Fuji IX following the addition of 5 wt.% TiO₂ and MgHAp100 but decreased in Ketac Molar comprising 5 wt.% MgHAp100 (<i>p</i> < 0.05). Achieving a predictable bond between NPs and cement matrix, as well as ensuring a uniform distribution of the NPs within the cement, are critical prerequisites for enhancing the mechanical performance of the original cement.</p>","PeriodicalId":14985,"journal":{"name":"Journal of Applied Biomaterials & Functional Materials","volume":"22 ","pages":"22808000241282184"},"PeriodicalIF":3.1,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142466041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chitosan-based promising scaffolds for the construction of tailored nanosystems against osteoporosis: Current status and future prospects.","authors":"Ya-Ming Wang, Jiang-Tao Shen","doi":"10.1177/22808000241266487","DOIUrl":"https://doi.org/10.1177/22808000241266487","url":null,"abstract":"<p><p>Despite advancements in therapeutic techniques, restoring bone tissue after damage remains a challenging task. Tissue engineering or targeted drug delivery solutions aim to meet the pressing clinical demand for treatment alternatives by creating substitute materials that imitate the structural and biological characteristics of healthy tissue. Polymers derived from natural sources typically exhibit enhanced biological compatibility and bioactivity when compared to manufactured polymers. Chitosan is a unique polysaccharide derived from chitin through deacetylation, offering biodegradability, biocompatibility, and antibacterial activity. Its cationic charge sets it apart from other polymers, making it a valuable resource for various applications. Modifications such as thiolation, alkylation, acetylation, or hydrophilic group incorporation can enhance chitosan's swelling behavior, cross-linking, adhesion, permeation, controllable drug release, enzyme inhibition, and antioxidative properties. Chitosan scaffolds possess considerable potential for utilization in several biological applications. An intriguing application is its use in the areas of drug distribution and bone tissue engineering. Due to their excellent biocompatibility and lack of toxicity, they are an optimal material for this particular usage. This article provides a comprehensive analysis of osteoporosis, including its pathophysiology, current treatment options, the utilization of natural polymers in disease management, and the potential use of chitosan scaffolds for drug delivery systems aimed at treating the condition.</p>","PeriodicalId":14985,"journal":{"name":"Journal of Applied Biomaterials & Functional Materials","volume":"22 ","pages":"22808000241266487"},"PeriodicalIF":3.1,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141916728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Picoscopy Discoveries of the Binary Atomic Structure","authors":"Olexandr Kucherov, Andrey Mudryk","doi":"10.35745/afm2023v03.02.0001","DOIUrl":"https://doi.org/10.35745/afm2023v03.02.0001","url":null,"abstract":"In this article, we present a discovery of the binary atomic structure. Through picoscopy experiments, it was revealed that electronic structure is divided into core and functional structures. Internal chemically neutral electrons form the core of an atom and are spherical in pink, while the outer functional electrons are elongated in green being chemically active. A spherical yellow layer separates these two parts. It significantly simplifies the Schrödinger equation and leads to a solution for all 118 chemical elements. As a result, the Kucherov-Mudryk formula w = n + ¾l was derived. That formula allowed for organizing the periodic table in ascending order of the whole energy where en electron first fills the level with the lowest energy, according to the Minimum Potential Energy general principle of nature.","PeriodicalId":14985,"journal":{"name":"Journal of Applied Biomaterials & Functional Materials","volume":"5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136369198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Ga Concentration on the Output Performance of ZnO Piezoelectric Nanorods Nanogenerator","authors":"Tung-Lung Wu, Teen-Hang Meen, Yu-Chuan Chang","doi":"10.35745/afm2023v03.02.0002","DOIUrl":"https://doi.org/10.35745/afm2023v03.02.0002","url":null,"abstract":"In this study, a self-assembled monolayer of octyltriethoxysilane was grown on ITO glass. Subsequently, a hydrothermal method was employed to grow low-density gallium (Ga)-doped zinc oxide (ZnO) nanorod structures. In this growth process, the undoped pure ZnO nanorods and ZnO nanorods doped with five different Ga concentrations were developed. After growing the nanorods, X-ray diffraction (XRD) analysis was conducted on both undoped pure ZnO and Ga-doped ZnO nanorods to observe the influence of Ga concentration on the crystalline structure of the ZnO nanorods. Additionally, scanning electron microscopy (SEM) was utilized to examine changes in the surface and cross-sectional growth of ZnO nanorods with varying Ga concentrations, thereby investigating the impact of Ga concentration on the growth of ZnO nanorods. Finally, a thin Pt film was sputtered onto the ZnO nanorod structures to assemble nanogenerators. Ultrasonic excitation was applied to develop these nanogenerators for electrical measurements, allowing us to explore the effects of metal doping on the nanorods’ electrical properties.","PeriodicalId":14985,"journal":{"name":"Journal of Applied Biomaterials & Functional Materials","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136368946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Platinum Nanotubes Calculated Using Relativistic Cylindrical Wave Technique: Chiral Induced Spin Selectivity","authors":"P. D’yachkov, E. D’yachkov","doi":"10.35745/afm2023v03.01.0001","DOIUrl":"https://doi.org/10.35745/afm2023v03.01.0001","url":null,"abstract":"Electronic and spin properties of chiral platinum nanotubes are calculated using the relativistic linear augmented cylindrical waves method. The spin-orbit coupling induces the strong splitting of nonrelativistic dispersion curves for the Fermi energy region. The large differences in spin densities of states for spins up and down can be used to create pure spin currents through the tubules. In the two series Pt (5, n2) and Pt (10, n2), the (5, 3) and (10, 7) nanotubes show the strongest chirality-induced spin selectivity effects.","PeriodicalId":14985,"journal":{"name":"Journal of Applied Biomaterials & Functional Materials","volume":"165 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2023-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76924819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biodiesel Production: Agricultural and Economical Aspect in India","authors":"V. Kumar, Sudhaker Dixit, Soni Gautam, Saransh Tiwari, Ajay Singh Yadav","doi":"10.35745/afm2023v03.01.0002","DOIUrl":"https://doi.org/10.35745/afm2023v03.01.0002","url":null,"abstract":"The production of biodiesel attracts attention from scientists and researchers as of its tremendous applications and commercial use. It becomes important as of its eco-friendly nature, too, as it is biodegradable and non-polluting. The advantages of using petro-diesel with biodiesel lie in diminishing air pollution, encouraging the domestic supply of fuel, and creating new opportunities in agriculture. The production of biodiesel provides an alternative for agriculture as well as the industry. Focusing on short-duration annual crops that can generate fuel and oil seed crops provides numerous opportunities for small farmers. The intention of biodiesel concerns for creation and fortification of the environment. It is economically beneficial in several ways, namely by creating new jobs in the food and farming industries. Biodiesel fuel is eco-friendly and replaces petro-diesel. Previous studies showed that pollutants such as CO, CO2, SOX, HC, PAH, PM, and others can be reduced by using blended and pure biodiesel. However, the emission of NOX increases by using biodiesel. Biodiesel also provides a means to recycle CO2 which is mainly responsible for global warming. Biodiesel has been produced using plant oils such as Jatropha oil, Cottonseed oil, Pongamia oil, Palm oils, Rapeseed oil, and Castor oil. Such oils are converted to biodiesel through transesterification. We investigated the potential of Jatropha oil as a source of biodiesel. Biodiesel has become an eco-friendly and alternative fuel with many aspects in industrial use. When the use of biodiesel becomes more popular than petroleum fuel, the supply must be sufficient to meet daily needs. Therefore, the presented review article describes production, properties, agricultural benefits, marketing, and the prospect of biodiesel.","PeriodicalId":14985,"journal":{"name":"Journal of Applied Biomaterials & Functional Materials","volume":"127 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2023-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80087775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Slippery lubricant-infused silica nanoparticulate film processing for anti-biofouling applications.","authors":"Yuen Yee Li Sip,&nbsp;Annabel Jacobs,&nbsp;Alejandra Morales,&nbsp;Mengdi Sun,&nbsp;Luke B Roberson,&nbsp;Mary E Hummerick,&nbsp;Herve Roy,&nbsp;Pieter Kik,&nbsp;Lei Zhai","doi":"10.1177/22808000231184688","DOIUrl":"10.1177/22808000231184688","url":null,"abstract":"<p><p>Microbial biofilm build-up in water distribution systems can pose a risk to human health and pipe material integrity. The impact is more devastating in space stations and to astronauts due to the isolation from necessary replacement parts and medical resources. As a result, there is a need for coatings to be implemented onto the inner region of the pipe to minimize the adherence and growth of biofilms. Lubricant-infused surfaces has been one such interesting material for anti-biofouling applications in which their slippery property promotes repellence to many liquids and thus prevents bacterial adherence. Textured and porous films are suitable substrate candidates to infuse and contain the lubricant. However, there is little investigation in utilizing a nanoparticulate thin film as the substrate material for lubricant infusion. A nanoparticulate film has high porosity within the structure which can promote greater lubricant infusion and retention. The implementation as a thin film structure aids to reduce material consumption and cost. In our study, we utilized a well-studied nanoporous thin film fabricated via layer-by-layer assembly of polycations and colloid silica and then calcination for greater stability. The film was further functionalized to promote fluorinated groups and improve affinity with a fluorinated lubricant. The pristine nanoporous film was characterized to determine its morphology, thickness, wettability, and porosity. The lubricant-infused film was then tested for its lubricant layer stability upon various washing conditions and its performance against bacterial biofilm adherence as a result of its slippery property. Overall, the modified silica nanoparticulate thin film demonstrated potential as a base substrate for lubricant-infused surface fabrication that repelled against ambient aqueous solvents and as an anti-biofouling coating that demonstrated low biofilm coverage and colony forming unit values. Further optimization to improve lubricant retention or incorporation of a secondary function can aid in developing better coatings for biofilm mitigation.</p>","PeriodicalId":14985,"journal":{"name":"Journal of Applied Biomaterials & Functional Materials","volume":"21 ","pages":"22808000231184688"},"PeriodicalIF":2.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10238836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}