Journal of Applied Biomaterials & Functional Materials最新文献

{"title":"Chitosan-coated titanium screws: Enhancing biofilm resistance, mechanical stability, and osseointegration in orthopedic implants.","authors":"Niranjan Ghimire, Manish Rayamajhi, Yuyu Sun, Ying Deng","doi":"10.1177/22808000251358057","DOIUrl":"https://doi.org/10.1177/22808000251358057","url":null,"abstract":"<p><p>Orthopedic implant-associated infections, primarily caused by biofilm-forming <i>Staphylococcus aureus</i>, pose significant clinical challenges. These infections often lead to implant failure, prolonged antibiotic treatments, and an increased risk of revision surgeries, emphasizing the need for effective biofilm-resistant implant materials. In this study, we present a dual-functional titanium screw (Ti-S) grafted with chitosan (Cs), a biocompatible polymer known for its osteogenic and antimicrobial properties while maintaining mechanical integrity. The chitosan-modified titanium screw (Cs-Ti-S) was prepared via chemical immobilization to enhance resistance to biofilm formation while promoting osseointegration and preserving biomechanical integrity. Biomechanical testing confirmed that chitosan modification did not compromise mechanical performance, as Cs-Ti-S exhibited a torsional yield strength of 1.70 ± 0.00 Nm compared to 1.76 ± 0.05 Nm for unmodified titanium screws (Un-Ti-S), and an axial pullout force of 68.66 ± 14.36 N for Cs-Ti-S versus 70.33 ± 9.71 N for Un-Ti-S. Micro-scratch tests revealed similar hardness values (1.26 ± 0.03 GPa for Cs-Ti-S vs. 1.40 ± 0.07 GPa for Un-Ti-S) and scratch resistance, ensuring surface durability. Gene expression analysis showed upregulated β1-integrin on Cs-Ti-S at 24 h post-infection, indicating improved osteoblast adhesion. Scanning electron microscopy (SEM) analysis confirmed significantly reduced bacterial biofilm formation on Cs-Ti-S. Moreover, the combination of povidone-iodide (PI) treatment on Cs-Ti-S surfaces significantly inhibited biofilm formation over 7 days, unlike Un-Ti-S, which retained significant adhesion. These results suggest chitosan grafting as a scalable, non-antibiotic strategy to enhance antimicrobial resistance and osseointegration.</p>","PeriodicalId":14985,"journal":{"name":"Journal of Applied Biomaterials & Functional Materials","volume":"23 ","pages":"22808000251358057"},"PeriodicalIF":3.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144955245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel 2D MXenes biocomposite for the removal of emerging organic contaminants from wastewater.","authors":"Sweta Raj, Divya Bajpai Tripathy, Lalit Prasad, Anil Kumar","doi":"10.1177/22808000251360553","DOIUrl":"https://doi.org/10.1177/22808000251360553","url":null,"abstract":"<p><p>Growing ecological and public health issues brought on by the increasing presence of novel organic contaminants in wastewater need the development of innovative remediation solutions. It's usually challenging for conventional treatment methods to effectively collect these contaminants, which include pharmaceuticals, personal care products, and industrial chemicals. Scientists are, therefore, concentrating on innovative material to increase the efficiency of adsorption and removal. Because they facilitate interaction with a range of organic pollutants, 2D MXenes' unique structural and chemical properties have drawn interest from these materials. MXenes are very excellent adsorbents for a variety of contaminants because of their large surface area, many terminal groups, and distinctive 2D layer architectures. Polyfluoroalkyl substances (PFAS), dyes, antibiotics (tetracycline, sulfonamides, and ciprofloxacin), amitriptyline, verapamil, carbamazepine, 17α-ethinyl estradiol, antibiotic resistance genes (ARGs), diclofenac, ibuprofen heavy metals, and other contaminants have all been claimed to be eliminated by MXenes. Recent studies propose the formulation of MXene-based biocomposites, which not only harness the high surface area and electrical conductivity of MXenes but also integrate biodegradable components to promote eco-friendliness. This work explores the potential of novel 2D MXenes biocomposites in addressing the critical challenge of wastewater treatment, focussing on their efficiency, and sustainability in removing emerging contaminants.</p>","PeriodicalId":14985,"journal":{"name":"Journal of Applied Biomaterials & Functional Materials","volume":"23 ","pages":"22808000251360553"},"PeriodicalIF":3.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144955273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A composite bioink derived from lacrimal gland extracellular matrix and alginate.","authors":"Luis Kasimir Leo, Katharina Elisabeth Wiebe-Ben Zakour, Julia Matros, Michael Christian Hacker, Florian Kai Groeber-Becker, Gerd Geerling, Joana Witt","doi":"10.1177/22808000251389486","DOIUrl":"https://doi.org/10.1177/22808000251389486","url":null,"abstract":"<p><p>With the high global prevalence of dry eye disease and around 17% attributed to aqueous deficient dry eye (ADDE), there is an urgent need for therapies targeting lacrimal gland (LG) insufficiency. Advancements in in vitro LG analysis are essential for developing effective treatments that allow for efficient, ethical, and comprehensive evaluation of both cell-based therapies and pharmaceuticals. In light of the rapid progress in 3D bioprinting for tissue engineering, this study focuses on creating a composite hydrogel derived from decellularized porcine LG, combined with alginate. This combination leverages the bioactivity of the decellularized extracellular matrix (dECM) with the favorable biomechanical properties of alginate in a single bioink. Our results demonstrate that dECM supports the in vitro culture of LG cell types effectively, while alginate provides enhanced biomechanical stability. We analyzed the biomechanical and rheological properties of the bioink and printed 3D structures containing LG-derived cells, assessing cell viability both immediately post-printing and over a 7-day culture period. The LG-based bioink showed shear-thinning behavior, reduced cell sedimentation, and resilience to shear stresses comparable to pure alginate hydrogels. Additionally, we observed excellent viability of LG epithelial and mesenchymal stromal cells. This composite bioink, combining dECM and alginate, presents improved biomechanical properties while preserving biofunctionality, representing a promising platform for in vitro LG tissue engineering.</p>","PeriodicalId":14985,"journal":{"name":"Journal of Applied Biomaterials & Functional Materials","volume":"23 ","pages":"22808000251389486"},"PeriodicalIF":3.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145421854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Barium titanate synthesis, mechanism of action and its applications in dentistry: A literature review.","authors":"Rand Naseer Kadhum, Thekra Ismael Hamad","doi":"10.1177/22808000251375714","DOIUrl":"https://doi.org/10.1177/22808000251375714","url":null,"abstract":"<p><strong>Background: </strong>In recent years, barium titanate (BaTiO₃) has demonstrated advancements in the field of dentistry among dental ceramics. This ceramic substance has piezoelectric qualities that are comparable to those of bone, which is crucial for osseointegration. The biomedical field has made extensive use of barium titanate for its affordability, chemical stability, and non-toxicity. The use of barium titanate in dentistry is encouraged by the fact that many widely used metal alloys have unsightly hues and exhibit chemical interactions in the mouth cavity. Because BaTiO₃-based ceramics are more corrosion-resistant, have better color matching that improves esthetics, stronger, and have better radiopacity than traditional biomaterials, their use has grown.</p><p><strong>Purpose: </strong>This review will cover the production techniques, mechanism of action, phases, and dental uses of BaTiO₃.</p><p><strong>Conclusion: </strong>Barium titanate exhibited encouraging qualities for dental uses due to its antibacterial, biocompatible and piezoelectric action.</p>","PeriodicalId":14985,"journal":{"name":"Journal of Applied Biomaterials & Functional Materials","volume":"23 ","pages":"22808000251375714"},"PeriodicalIF":3.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145137489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhanced bone regeneration with cerium-doped bioactive glasses: In vitro and in vivo study.","authors":"Roberta Salvatori, Alexandre Anesi, Luigi Chiarini, Mattia Di Bartolomeo, Arrigo Pellacani, Chiara Cavazzoli, Alfonso Zambon, Gigliola Lusvardi","doi":"10.1177/22808000251326794","DOIUrl":"https://doi.org/10.1177/22808000251326794","url":null,"abstract":"<p><strong>Background: </strong>Bioactive cerium-doped (Ce-BGs) glasses with proven antioxidant properties, which may reduce post-implant oxidative stress, were studied in vitro and in vivo to evaluate their application in bone regeneration. Based on the Kokubo (K) composition, they contain 3.6 and 5.3 mol% cerium (referred to as K3.6 and K5.3, respectively).</p><p><strong>Methods: </strong>Ce-BGs were synthesized by melting and sieved to produce granules (size range = 200-500 µm). In vitro studies were conducted against MLO-Y4 cells using direct Neutral Red (NR) and indirect Bromo-2-deoxyUridine (BrdU) assays to assess cell viability and proliferation respectively. In vivo studies were carried out using a New Zealand white rabbit model to evaluate bone healing potential.</p><p><strong>Results and discussion: </strong>NR results showed a significant increase in cell viability for Ce-BGs: 77% for K and 79 and 85% for K3.6 and K5.3, after 24 h. After 72 h, cell viability decreased for K to 58% and increased for K3.6 and K5.3 (76% and 116% respectively). Cerium inhibits cell proliferation in BrdU assay as explainable by the increased durability of Ce-BGs. In vivo studies, after 30 and 60 days, revealed a delayed degradation for Ce-BGs that can stimulate the osteo-regeneration without inflammatory or degenerative effects. Moreover, the new bone area (NBA) was higher for Ce-BGs compared to control; after 60 days 32% for K5.3 versus 21% for K.</p><p><strong>Conclusions: </strong>Ce-BGs granules show improved direct cytocompatibility in vitro and enhance the long-term bone remodeling process in vivo, contributing to a more controlled and effective bone healing compared to the K granules. This improved behavior can be linked to the antioxidant and anti-inflammatory properties of cerium, that can assist bone regeneration and reduce implant-associated inflammation, and to their slower dissolution rate that supports the controlled release of ions. These results suggest Ce-BGs as a promising device for therapeutic applications on <i>hard</i> tissues.</p>","PeriodicalId":14985,"journal":{"name":"Journal of Applied Biomaterials & Functional Materials","volume":"23 ","pages":"22808000251326794"},"PeriodicalIF":3.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144025965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating the early osteogenic potential of strontium doped titanium alloy surface.","authors":"Ali Alenezi, Mohamed Ahmed Alkhodary","doi":"10.1177/22808000251328992","DOIUrl":"https://doi.org/10.1177/22808000251328992","url":null,"abstract":"<p><p>The current study was conducted to test the early osteogenic potential of strontium (Sr) doped titanium-aluminum-vanadium (Ti-6Al-4V) alloy using an in vitro cell culture experiment. Thirty Ti-6Al-4V alloy sheets were sandblasted and etched with large grit acid. Of these, 10 alloy sheets represented group I, 10 sheets doped with Sr using a hydrothermal process represented group II, and 10 sheets also coated with Sr-supplemented hydroxyapatite using a hydrothermal process represented group III. The surfaces of the three groups were characterized by scanning electron microscopy (SEM), energy dispersive spectroscopy (EDS), and X-ray diffraction (XRD). The three groups were also compared in terms of their water contact angle, protein adsorption, and Sr ion release profile. Further, bone marrow mesenchymal cells (BMSCs) obtained from the femora of 10 Sprague Dawley rats were used for the in vitro cell culture experiment, and the viability of the cultured cells was evaluated using the MTT assay and confocal microscopy; in addition, their osteogenic potential was assessed using alkaline phosphatase ALP activity. For statistical analysis, data were analyzed using one-way analysis of variance (ANOVA; IBM SPSS statistics 23), and <i>p</i> < 0.05 was considered statistically significant. SEM images revealed that the three groups had surface roughness, and EDS and XRD revealed the success of incorporating Sr to their surfaces. Group III had the best contact angle, protein adsorption, and Sr ion release rate. The cell culture also revealed that the surfaces of the titanium alloy sheets in group III were the most viable and had the best osteogenic potential; however, there was no statistically significant difference between groups I and II. In Conclusion, Sr alone was not able to improve the osteogenic potential of titanium alloy surfaces.</p>","PeriodicalId":14985,"journal":{"name":"Journal of Applied Biomaterials & Functional Materials","volume":"23 ","pages":"22808000251328992"},"PeriodicalIF":3.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144021745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Resveratrol-loaded PCL-PEG/GO/HAP biocomposite bone membranes: Evaluation of mechanical properties, release kinetics, and cellular response.","authors":"Betül Meryem Arpacay, Fatih Ciftci, Ali Can Özarslan, Mustafa Unal, Mine Kucak, Aslihan Yelkenci","doi":"10.1177/22808000251314087","DOIUrl":"10.1177/22808000251314087","url":null,"abstract":"<p><p>In this study, biocomposite membranes were developed by incorporating resveratrol (RSV)-loaded PCL-PEG composites, modified with graphene oxide (GO) and hydroxyapatite (HAP). The aim was to enhance hydrophilicity with GO and improve bioactivity with HAP. The release kinetics of RSV was evaluated by using Franz diffusion cells and compared with various kinetic models, including Korsmeyer-Peppas, Higuchi, and Baker, all of which showed high correlation coefficients (<i>R</i>²) close to 0.99. Mechanical tests was performed to determine the suitability of these membranes for tissue engineering applications. The composite membrane modified with GO and HAP exhibited tensile strength of 105.2 ± 5.8 MPa, tensile modulus of 3895 ± 159 MPa, elongation at break of 8.4 ± 0.9%, and toughness of 5.88 ± 0.46 MJ/m³. In vitro cell adhesion studies, visualized using DAPI fluorescence staining, demonstrated increased cell adhesion to the composite membranes over periods of 1, 3, 5, 7, and 14 days. These findings highlight the potential of the RSV-loaded PCL-PEG membranes, enhanced with GO and HAP, for applications in bone tissue engineering.</p>","PeriodicalId":14985,"journal":{"name":"Journal of Applied Biomaterials & Functional Materials","volume":"23 ","pages":"22808000251314087"},"PeriodicalIF":3.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143080105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influences of multi-pass friction stir alloying on characterization of AZ91D alloy-based dual reinforcement bio-ceramic nano-composites.","authors":"Surendra Kumar Patel, Guoxin Dai, Lu Liu, Zhen Sun, Lei Shi","doi":"10.1177/22808000251314086","DOIUrl":"10.1177/22808000251314086","url":null,"abstract":"<p><p>In current study, microstructural, mechanical and corrosion behaviour were investigated with incorporation of dual reinforced AZ91D surface composites. This research was carried out for enhancement of the bio-degradability in biological environment. The surface composites were successfully fabricated by friction stir processing method with a rotation speed of 800 rpm, travel speed of 80 mm/min and 2.5° tilt angle at multi-passes. The surface properties were characterized via optical, SEM, EDS, XRD and EBSD techniques. The microstructure showed that the reinforcements were equally distributed into the surface matrix after 3-passes for sets of composites. After 3-passes FSP average grain diameter of the composite C (1.61 μm) was smaller than that of composite A (1.86 μm) and composite B (1.63 μm), because of the strong shear deformation and generated friction heat, which occurred via dynamic recrystallization between grains in the processed zones. The microhardness of Composite C (162 Hv) has a higher than the composite A (125.2 Hv) and composite B (146.2 Hv). The ultimate tensile strength of composite A (152.7 MPa) was greater than that of composite B (133 MPa) and composite C (111.3 MPa). Furthermore, the corrosion resistance at 7, 15 and 30 days of immersion of composite C was higher than that of composite A and composite B, because of the domino effects and better bio-mineralization with the addition of Y₂O₃ and ZrO₂ particles. The typically worn surface revealed reduced deep pits, pits and cracks due to better ionization of the hydrogen generated during immersion. Finally, this research was carried out for treatment of bone defects and fractures as well as improving corrosion resistance of the mg-containing biocompatible implants.</p>","PeriodicalId":14985,"journal":{"name":"Journal of Applied Biomaterials & Functional Materials","volume":"23 ","pages":"22808000251314086"},"PeriodicalIF":3.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143005941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Functionalization of nanoceria a dual approach to anticancer and antifungal applications.","authors":"Salama A Yaseen, Faizaa A Saif, Prabhakar B Undre","doi":"10.1177/22808000251354888","DOIUrl":"https://doi.org/10.1177/22808000251354888","url":null,"abstract":"<p><p>Cerium oxide nanoparticles (CeO₂ NPs) have unique physicochemical properties that make them suitable for various applications, particularly in biomedicine. To enhance their compatibility with biological systems, we functionalized these nanoparticles with selected amino acids, which significantly improved their potential for biomedical use, as our findings show. Cerium oxide has a fluorite-type structure and can exist in both trivalent and tetravalent states. Notably, cerium oxide also serves as an effective radioprotectant, offering selective protection to normal cells over tumor cells. The present embodiment provides functionalized cerium oxide nanoflakes with a plurality of amino acids. The surface modification by amino acids has been studied and characterized with various techniques. The cytotoxicity and the biological activity of nanoceria and the functionalization of nanoceria were evaluated. The result of this investigation shows the change in morphology structure and optical properties. The anticancer activity of the samples shows significant results against the MCF-7 and SCC-29B cell lines overall. In the case of comparing pure and functionalized nanoceria in the microbial study, the functionalization of nanoceria shows better significance by improving biological activity in some cases than synthesized/pure nanoceria and becomes suitable for biomedical applications. Therefore, the results show that the functionalization of nanoceria plays an important role in manufacturing and the possibility of using it as a therapeutic compound in the future to improve the public health of society.</p>","PeriodicalId":14985,"journal":{"name":"Journal of Applied Biomaterials & Functional Materials","volume":"23 ","pages":"22808000251354888"},"PeriodicalIF":3.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144690355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of fluoride varnish on the color stability and surface microhardness of bioactive restorative materials: An in vitro study.","authors":"Mihriban Gökcek Taraç, Melek Çam","doi":"10.1177/22808000251403913","DOIUrl":"https://doi.org/10.1177/22808000251403913","url":null,"abstract":"<p><p>The aim of the study is to evaluate the effect of fluoride varnishes on both the color stability and surface microhardness of different fluoride-releasing restorative materials exposed to beverages commonly consumed by children . This study was conducted as an in vitro experimental study design. Three different restorative materials (Dyract XP, Beautifil II, and Cention N) and a colorless fluoride varnish were used. The solutions in which the samples were immersed were selected as beverages commonly preferred by children: cherry juice, chocolate milk, and cola. Color changes of the samples were measured using a spectrophotometer at 1, 7, 14, and 28 days and calculated according to the CIEDE2000 total color difference formula. Surface microhardness values were measured using a digital microhardness testing device at 1 and 28 days. To assess the effects of variables and their interactions in repeated observation designs, generalized linear models and generalized linear mixed models were fitted. Following model estimation, Tukey's-adjusted estimated marginal means were computed to identify significant pairwise differences. Fluoride-releasing restorative materials exhibited varying degrees of color change and decrease in surface microhardness when immersed in different staining solutions. Among the tested materials, Cention N demonstrated the greatest color stability (ΔE=1.01 for fluoride applied group, ΔE=1.45 for the group without fluoride application) and least reduction in surface microhardness. Fluoride application initially caused a slight discoloration immediately after application. However, following immersion in different solutions, fluoride application appeared to enhance color stability (ΔE=1.59 in the varnish-applied group, ΔE=2.21 in the group without varnish application), but did not have a statistically significant effect on the surface microhardness. A negative correlation was observed between color change and surface microhardness; as the surface microhardness decreased, the extent of color change increased. This study highlights the prominent role of intraoral environmental factors in influencing the durability and aesthetic properties of fluoride-releasing restorative materials. Topical fluoride application has a beneficial effect on the color stability with a more pronounced effect observed with Cention N.</p>","PeriodicalId":14985,"journal":{"name":"Journal of Applied Biomaterials & Functional Materials","volume":"23 ","pages":"22808000251403913"},"PeriodicalIF":3.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145762860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}