Journal of Applied Biomaterials & Functional Materials最新文献

{"title":"Graphene oxide-reinforced thermosensitive hydrogel co-delivering paclitaxel and dexamethasone for restenosis prevention.","authors":"Jinping Sheng, Rui Jiang, Peng Wang, Jianhao Li, Feizhou Du","doi":"10.1177/22808000261421276","DOIUrl":"https://doi.org/10.1177/22808000261421276","url":null,"abstract":"<p><p>Restenosis remains a significant limitation of vascular intervention procedures, primarily driven by the proliferation and inflammation of human-derived vascular smooth muscle cells (hVSMCs). This study developed a thermosensitive chitosan/β-glycerophosphate (CS-β-GP) hydrogel reinforced with graphene oxide (GO) for the localized co-delivery of paclitaxel (PTX) and dexamethasone (DEX). The incorporation of GO increased the storage modulus from approximately 3.95 kPa to 6.96 kPa, enhancing mechanical strength and accelerating gelation near body temperature (~36°C-37°C). SEM analysis revealed a porous, interconnected structure that supports drug delivery, while swelling was moderate (~145% at 6 h) and degradation resistance was improved, with the hydrogel retaining 80% of its mass in PBS after 30 days. Drug loading favored PTX (70% at 60 μg/mL) over DEX (17%) with sustained release profiles. Biologically, the dual-drug hydrogel (CS-β-GP-GO@PTX-DEX) selectively reduced hVSMC viability, migration, proliferation (~30%, ~20%, and ~30%, respectively), while preserving endothelial cell viability (~60%) and lowering proinflammatory cytokines (IL-1β ~100 pg/mL, IL-6 ~110 pg/mL, TNF-α ~70 pg/mL). These findings establish the CS-β-GP-GO@PTX-DEX hydrogel as a mechanically robust, selective, and effective platform for preventing restenosis and enhancing vascular tissue regeneration.</p>","PeriodicalId":14985,"journal":{"name":"Journal of Applied Biomaterials & Functional Materials","volume":"24 ","pages":"22808000261421276"},"PeriodicalIF":3.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146194600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of the antibacterial properties of lipoic acid-functionalized silver nanoparticles.","authors":"Lhana Erylle A Dela Cruz, Richard D Espiritu, Eduardo R Magdaluyo","doi":"10.1177/22808000261442268","DOIUrl":"https://doi.org/10.1177/22808000261442268","url":null,"abstract":"<p><p>Silver nanoparticles (AgNPs) are increasingly explored as alternatives to conventional antibiotics in wound care due to their broad-spectrum antimicrobial activity. This study evaluates the antibacterial performance of α-lipoic acid-functionalized silver nanoparticles (AgNPs-LA) using an integrated experimental-computational approach combining molecular dynamics simulations and experimental validation. AgNPs-LA were synthesized via a controlled hydrothermal method employing biogenic reduction of silver ions to minimize cytotoxicity. Structural and compositional analyses confirmed successful surface functionalization with α-lipoic acid and D-glucose. Morphological characterization revealed predominantly spherical nanoparticles with diameters ranging from 37 to 90 nm. Antimicrobial agar disk diffusion assays demonstrated concentration-dependent inhibition of <i>Staphylococcus aureus</i>, <i>Pseudomonas aeruginosa</i>, and <i>Escherichia coli</i>. Specifically, AgNPs-LA at 40 μg/mL produced inhibition zones statistically comparable to gentamicin against <i>S.</i> <i>aureus</i> and <i>P.</i> <i>aeruginosa</i> (<i>p</i> > 0.05). Molecular dynamics simulations performed under isothermal-isochoric (constant number of particles, volume, and temperature; NVT) canonical ensemble indicated that the disulfide moiety of lipoic acid serves as the primary anchoring group to the silver surface, conferring stability through the formation of a structured hydrophobic surface layer. This interfacial configuration enhances nanoparticle stability and may improve pharmacokinetic clearance, thereby reducing the risk of systemic toxicity. Collectively, these findings highlight the potential of AgNPs-LA as a safe and effective antimicrobial platform for wound management applications.</p>","PeriodicalId":14985,"journal":{"name":"Journal of Applied Biomaterials & Functional Materials","volume":"24 ","pages":"22808000261442268"},"PeriodicalIF":3.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147772094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and characterization of a smart obstetric dressing with a visual indication function.","authors":"Chi-Kang Lin, Ting-Teng Wang, Meng-Yi Bai","doi":"10.1177/22808000261431501","DOIUrl":"https://doi.org/10.1177/22808000261431501","url":null,"abstract":"<p><p>Excessive adhesion between dressings and the wound bed often causes secondary tissue damage and delays healing during dressing removal. This study aimed to develop and evaluate a multifunctional moisture-containing nonwoven dressing composed of silk fibroin protein (SF), polycaprolactone (PCL), and ellagic acid (EA) to improve wound healing while allowing visual assessment of moisture. A composite nonwoven fabric integrating SF, PCL, and EA was fabricated and characterized using spectroscopic analysis to evaluate its fluorescence properties. In vitro cytocompatibility was assessed in the four fibroblast cell lines using cell viability assays. In vivo wound-healing efficacy was investigated in an animal model, and histological evaluation was performed using Masson's trichrome staining and histomorphometric analysis. Spectroscopic measurements indicated that SF and EA synergistically produced bright blue-violet fluorescence under UV illumination, with the fluorescence intensity increasing proportionally to the SF concentration. Cytocompatibility assays confirmed excellent biocompatibility, with all treatment groups maintaining >80% cell viability and the indicator fabric alone exceeding 100%. In vivo studies revealed that both the SF-based indicator fabric and the EA-integrated dressing significantly accelerated re-epithelialization and dermal remodeling compared to a commercial hydrogel control. Histological analysis revealed denser collagen deposition and increased neovascularization in the SF-treated wounds. The SF/PCL/EA moisture-indicating dressing demonstrated dual functionality by serving as an effective visual indicator of exudate and promoting tissue repair. This composite dressing provides both therapeutic and diagnostic benefits for advanced wound-care applications.</p>","PeriodicalId":14985,"journal":{"name":"Journal of Applied Biomaterials & Functional Materials","volume":"24 ","pages":"22808000261431501"},"PeriodicalIF":3.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147690495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does melatonin gel improve alveolar preservation? A triple-blind randomized controlled clinical trial.","authors":"Ingrid Chaves Cavalcante Kischinhevsky, Adriana Terezinha Neves Novellino Alves, Caio Márcio Sorrentino de Freitas Farias Dos Santos, Rafael Bonato, Suelen Cristina Sartoretto, Carlos Fernando Mourão, José Mauro Granjeiro, Mônica Diuana Calasans-Maia","doi":"10.1177/22808000261422958","DOIUrl":"https://doi.org/10.1177/22808000261422958","url":null,"abstract":"<p><strong>Background: </strong>Preserving ridge volume after tooth extraction is essential for predictable implant outcomes. Various techniques and biomaterials have been proposed to minimize post-extraction dimensional changes. Melatonin, a pineal hormone, is an important mediator of new bone formation. The effect of melatonin gel incorporated into a porcine xenogeneic collagen sponge in post-extraction sockets has not been evaluated in humans, making this trial novel.</p><p><strong>Purpose: </strong>To assess the effect of melatonin gel incorporated into a collagen sponge on intra-socket bone formation and tissue characteristics in post-extraction sockets.</p><p><strong>Materials and methods: </strong>Twenty participants requiring extraction of premolars or molars with adjacent teeth were randomly allocated to test (<i>n</i> = 10) and control (<i>n</i> = 10) groups. After extraction, sockets were filled with xenogenic collagen sponge containing either melatonin gel (1.2 mg; test) or placebo gel (control). Ninety days later, during implant placement, bone samples were harvested using a trephine drill. Samples were processed for histomorphometric analysis of newly formed bone and connective tissue. Secondary outcomes included descriptive microscopic histology, quantitative microcomputed tomography (µCT) analyses and intra-alveolar volumetric analysis.</p><p><strong>Results: </strong>Histomorphometry revealed significantly greater bone density in the test group (44.0%) than in the control group (35.4%; <i>p</i> = 0.0099), with a mean difference of 8.6% ± 3.2%. Microscopic evaluation showed increased osteoblastic activity in the test group. Quantitative µCT analysis confirmed more new bone formation in the test group, although qualitative bone characteristics did not differ between groups. The intra-alveolar bone volume formed was numerically higher in the test group than in the control group.</p><p><strong>Conclusion: </strong>Incorporating melatonin gel into a collagen sponge enhanced bone repair in human post-extraction sockets over 90 days. This clinical trial is registered at the Brazilian Clinical Trials Registry (ReBEC; https://ensaiosclinicos.gov.br): RBR-67jkxsj.</p>","PeriodicalId":14985,"journal":{"name":"Journal of Applied Biomaterials & Functional Materials","volume":"24 ","pages":"22808000261422958"},"PeriodicalIF":3.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146258246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Post-polymerization dimensional accuracy of fast and superfast vinylpolysiloxane-based jaw relation recording materials: An in vitro study.","authors":"Ali Y Alsaeed, Bandar M A Al-Makramani, Praveen Gangadharappa, Khurshid Mattoo, Mohammed E Sayed, Nisreen Nabiel Hassan, Ebrahim Fihaid Alsubaiy, Majed S Altoman, Saad Saleh AlResayes, Firas K Alqarawi","doi":"10.1177/22808000261431923","DOIUrl":"https://doi.org/10.1177/22808000261431923","url":null,"abstract":"<p><p>Development of a biocompatible functional dental occlusion requires maxillo mandibular relation records. Clinical errors in these physical records are mostly caused by protracted clinical setting times. If dimensionally accurate and stable, recently introduced fast and superfast vinlpolysiloxane-based recording materials could reduce these inaccuracies, however such studies have yet not been attempted. This in-vitro study determined the post-polymerization dimensional accuracy of novel fast/superfast vinyl polysiloxane (VPS)-based jaw relation recording materials (JRRM). Four VPS-based JRRMs (Primo, Mark 3, Jetbite, and Defend) with three polymerization variants [regular, fast, and superfast] were investigated for dimensional accuracy. 180 samples allotted to four controls [PR, MR, JR, DR] and eight experimental [fast set (PF, MF, JF, DF); superfast (PSF, MSF, JSF, DSF)] were observed under a stereomicroscope using three different measurement coordinates between the X and Y axes, as specified by american dental association specification number 19. A one-way ANOVA (Kruskal-Wallis) rank test determined median scores, followed by a post hoc (Dunn) test. All probability \"p\" values were judged to be significant at 0.05. The one-way ANOVA showed significant differences between studied groups, with all regular setting JRRMs except Mark 3 showing the least overall linear changes, followed by super-fast set and fast set. Gp MR showed the highest [Mdn(IQR); 25.19(0.02)], while Gp DSF showed the least [25.00(0.02)] against original die measurements. All fast-set and superfast-set JRRMs showed expansion in terms of physical change. Mark 3 (regular, fast, and superfast) showed clinically unacceptable dimensional changes after 1 h of VPS-based JRRM setting. Defend Superfast was the most accurate material, including regular. Clinically, different variants fulfill dimensional accuracy and stability at various time intervals, therefore different variants may be indicated for specific purposes in fabrication of occlusion for a dental prosthesis.</p>","PeriodicalId":14985,"journal":{"name":"Journal of Applied Biomaterials & Functional Materials","volume":"24 ","pages":"22808000261431923"},"PeriodicalIF":3.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147529184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interface-programmed regeneration of segmental bone defects with biomimetic mineral-coated β-TCP microparticles.","authors":"Bingyao Chen, Lufeng Yao, Keye Chen, Yanguang Zhou, Chenxin Wang, Xiaodong Xu, Jinxia Ma, Jiayu Chen, Deting Xue, Zhaoming Ye, Xiaohua Yu","doi":"10.1177/22808000261431927","DOIUrl":"https://doi.org/10.1177/22808000261431927","url":null,"abstract":"<p><p>Large segmental bone defects remain difficult to treat: autografts are limited by supply and morbidity, while calcium-phosphate substitutes often deliver inconsistent outcomes. This inconsistency largely originates at the early post-implantation interface, where protein adsorption and Ca²⁺/PO₄^3- flux are unpredictable and lack a scalable solution. We therefore engineered mineral-coated microparticles (MCM) by growing a conformal, low-crystallinity apatite nanolayer on porous β-TCP under aqueous, protein-compatible conditions, preserving interconnected porosity. The coating establishes a uniform, stable protein corona and attenuates burst while smoothing ion release; in a rabbit mandibular critical-size model, MCM achieved more complete bridging, denser μCT infill, and higher bone mineral density than β-TCP and β-TCP/HA. Collectively, these data support a growth-factor-free, interface-first design that delivers more consistent regeneration and is readily translatable as an off-the-shelf particulate filler.</p>","PeriodicalId":14985,"journal":{"name":"Journal of Applied Biomaterials & Functional Materials","volume":"24 ","pages":"22808000261431927"},"PeriodicalIF":3.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147463288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Push-out bond strength of bioceramic-based sealers following different irrigation activation techniques.","authors":"Fatma Begüm Peker, Hümeyra Çapkın, Ahsen Narbay","doi":"10.1177/22808000261424357","DOIUrl":"https://doi.org/10.1177/22808000261424357","url":null,"abstract":"<p><strong>Background: </strong>The adhesion of root canal sealers to dentin plays a decisive role in the long-term success of endodontic treatment. Activation of irrigants before obturation has been suggested to enhance sealer penetration and bonding effectiveness. This study aimed to evaluate the effect of different irrigation activation techniques on the push-out bond strength of two bioceramic-based sealers to root dentin.</p><p><strong>Materials and methods: </strong>Eighty extracted human single-rooted teeth were decoronated to a standardized length and instrumented using rotary files with sodium hypochlorite irrigation. Specimens were randomly allocated into four groups according to the irrigation activation technique: conventional needle irrigation (control; lateral side-vented needle), manual dynamic agitation (MDA), EndoActivator, and EDDY (<i>n</i> = 20 each). Each group was further subdivided based on the sealer used-BioRoot RCS or GuttaFlow Bioseal (<i>n</i> = 10 each)-and obturated using the single-cone technique. The roots were sectioned into coronal, middle, and apical thirds, and push-out bond strength was measured using a universal testing machine. Failure modes were analyzed under a stereomicroscope.</p><p><strong>Results: </strong>A statistically significant regional variation was observed only in the EDDY-BioRoot RCS group, with the highest bond strength recorded in the coronal third (<i>p</i> < 0.05). In intergroup comparisons, significant differences were detected among experimental and control groups in the coronal region (<i>p</i> < 0.001), with the EDDY-BioRoot RCS group demonstrating superior bond strength compared to both activated and non-activated GuttaFlow groups. No statistically significant differences were observed among groups in the middle and apical thirds (<i>p</i> > 0.05). When data were pooled across activation protocols, BioRoot RCS exhibited significantly higher bond strength than GuttaFlow Bioseal in the coronal and middle regions (<i>p</i> < 0.05).</p><p><strong>Conclusions: </strong>Both the irrigation activation technique and the choice of calcium silicate-based sealer significantly influence push-out bond strength, predominantly in the coronal region. Sonic activation with EDDY in combination with BioRoot RCS yields the most favorable bonding performance. The diminishing effect toward the apical region underscores the need for further optimization of activation strategies to enhance sealer-dentin adhesion throughout the entire root canal system.</p>","PeriodicalId":14985,"journal":{"name":"Journal of Applied Biomaterials & Functional Materials","volume":"24 ","pages":"22808000261424357"},"PeriodicalIF":3.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146258292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hydrogels for 3D-printed breast scaffolds on esthetic, functional, and oncological safety: A review.","authors":"Zhuoyue Li, Shuqin Wang, Qian Tan","doi":"10.1177/22808000261431929","DOIUrl":"https://doi.org/10.1177/22808000261431929","url":null,"abstract":"<p><p>Breast volume loss after cancer surgery severely affects patients' physical and psychological well-being, while traditional reconstruction methods such as prosthetic implantation and autologous tissue transfer are limited by complications, donor-site morbidity, and poor long-term stability. To address these issues, this review summarizes recent advances in hydrogel-based 3D-printed scaffolds for breast reconstruction. The review focuses on the use of different 3D bioprinting techniques in scaffold manufacture and compares natural and synthetic hydrogels in terms of biocompatibility, mechanical properties, and biodegradability. It also involves core design principles for scaffolds to meet the unique anatomical and functional requirements of the breast, including tunable softness, promotion of vascularization, and tissue integration. Furthermore, recent applications of hydrogel-based 3D printing in adipose tissue regeneration and nipple-areola complex reconstruction are discussed in detail. The findings indicate that natural hydrogels provide advantages in cell viability and differentiation due to their biocompatibility, while synthetic hydrogels offer tunability and structural stability for long-term support. Combining the two materials can enhance reconstruction outcomes. It further addresses challenges and prospective directions in 3D printing hydrogels in breast reconstruction, paving the way for innovative research to material selection and printing strategies, enhancing patient care, and improving quality of life.</p>","PeriodicalId":14985,"journal":{"name":"Journal of Applied Biomaterials & Functional Materials","volume":"24 ","pages":"22808000261431929"},"PeriodicalIF":3.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147468141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tribocorrosion response of Fe-modified titanium alloys in simulated body fluids with varying glucose concentrations.","authors":"Nicola Rundora, Desmond Klenam, Oluwasegun Falodun, Maria Mathabathe, Vusumuzi Sibanda, Michael Bodunrin","doi":"10.1177/22808000261431504","DOIUrl":"https://doi.org/10.1177/22808000261431504","url":null,"abstract":"<p><p>This study evaluates the tribocorrosion behavior of Fe-modified titanium alloys (Ti-3Fe, Ti-4.5Al-1V-3Fe, Ti-6Al-1V-3Fe) in comparison with Ti-6Al-4V in Hank's balanced salt solution (HBSS) simulating normal (0 mg/dL), pre-diabetic (100 mg/dL) and diabetic (200 mg/dL) physiological glucose conditions. Tribocorrosion tests were conducted using a reciprocating sliding configuration under open-circuit potential (OCP) and potentiostatic control (+0.5 V vs Ag/AgCl) to assess passive film stability, depassivation-repassivation kinetics and wear-corrosion synergy. Mechanical sliding induced cathodic OCP transients due to passive film rupture, with Ti-3Fe showing the largest potential drop (0.61 V, from -0.42 to -1.03 V) and negligible recovery (<0.01 V), indicating poor repassivation. In contrast, Ti-6Al-1V-3Fe and Ti-6Al-4V exhibited anodic OCP recovery of +0.059 and +0.095 V, reflecting enhanced passive film reformation. Under potentiostatic conditions, Ti-3Fe recorded peak sliding current densities of 6.4 × 10⁻⁴ A, while Ti-6Al-1V-3Fe and Ti-6Al-4V remained below 4.3 × 10⁻⁴ A, indicating higher resistance to depassivation. Increasing glucose concentration progressively destabilized the electrochemical response, with OCP fluctuation ranges increasing from 0.05 V in normal HBSS to 0.09 V in diabetic HBSS, accompanied by elevated sliding current densities and reduced post-sliding recovery. Wear analysis showed the lowest specific wear rate for Ti-6Al-4V (1.68 × 10⁻⁶ mm³/N·m) in normal HBSS, while Ti-3Fe consistently exhibited the highest material loss across all environments. The results show that alloy composition and glucose concentration in physiological media significantly influence tribocorrosion behavior, with Al-V-containing alloys demonstrating superior electrochemical stability and wear resistance, while Fe-rich titanium alloys exhibit greater susceptibility, particularly under diabetic conditions.</p>","PeriodicalId":14985,"journal":{"name":"Journal of Applied Biomaterials & Functional Materials","volume":"24 ","pages":"22808000261431504"},"PeriodicalIF":3.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147838230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tissue response, antimicrobial activity, and mechanical properties of calcium silicate cement prototypes for vital pulp therapies.","authors":"Elizabeth Luna-Jaramillo, Rubén Abraham Domínguez-Pérez, Otoniel Corrales-Lozano, Manuel López-Rodríguez, Rosa Martha Pérez-Serrano, Marina Vega-González, León Francisco Espinosa-Cristóbal, Roberto Gustavo Sánchez-Lara Y Tajonar","doi":"10.1177/22808000251408320","DOIUrl":"https://doi.org/10.1177/22808000251408320","url":null,"abstract":"<p><p>The use of hydraulic calcium silicate cements (HCSCs) is essential for vital pulp therapies (VPT). However, their high cost restricts access in low- and middle-income countries, preventing the widespread benefits of VPT. This study aimed to evaluate four previously developed and characterized low-cost HCSC prototypes by examining their biological properties, specifically the rat connective tissue response after implantation and antimicrobial activity against five strains of interest. Additionally, their compressive strength, bond strength, and microhardness, which are critical mechanical properties of materials used in VPT, were assessed. All HCSCs caused an inflammatory reaction, which decreased over time in all cases, with most reactions categorized as mild. When comparing the number of inflammatory cells at each time point, no significant differences were observed between the HCSCs and those compared to MTA Angelus. Regarding the fibrous capsule, its thickness gradually decreased, and all capsules ultimately had a thickness with no significant difference compared to those formed in the empty control group. No significant differences in antimicrobial activity were seen among the four prototypes, as they exhibited similar performance against the five tested strains. However, some prototypes showed significantly better performance compared to MTA Angelus. Concerning mechanical properties, most prototypes exhibited substantially higher compressive strength than MTA Angelus, with a gradual increase over time-though this increase was not always significant. Additionally, no prototype demonstrated significant differences in bond strength compared to each other or MTA Angelus. Microhardness also increased over time, with significant differences observed when comparing prototypes to MTA Angelus at each time point. These findings, along with previously reported data on their microstructure, composition, and physical properties, support the potential clinical use of these prototypes. However, further research is needed to evaluate their effectiveness in clinical settings.</p>","PeriodicalId":14985,"journal":{"name":"Journal of Applied Biomaterials & Functional Materials","volume":"24 ","pages":"22808000251408320"},"PeriodicalIF":3.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145889341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}