Bioactive oligopeptides and the application in skin regeneration and rejuvenation.

IF 3.1 4区医学 Q2 BIOPHYSICS

Journal of Applied Biomaterials & Functional Materials Pub Date : 2025-01-01 Epub Date: 2025-04-23 DOI:10.1177/22808000251330974

Qiulin He, Youguo Liao, Yaru Wu, Huahui Zhang, Xiaohui Long, Yuxiang Zhang

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引用次数: 0

Abstract

Oligopeptides, composed of 2-10 amino acid residues, are protein fragments with unique structural characteristics, including small molecular size, high biocompatibility, and modifiable functional groups. These features endow oligopeptides with excellent permeability, safety, and versatile biological activities, making them widely applicable in disease treatment, drug delivery, and skincare. In particular, oligopeptides have emerged as advanced ingredients in skincare, offering anti-aging, anti-wrinkle, and whitening effects by regulating key biological processes such as collagen synthesis, antioxidant defense, and melanin production. This review comprehensively discusses the structural properties, functional mechanisms, and diverse applications of oligopeptides and their derivatives, highlighting their potential in skin regeneration, rejuvenation, and anti-aging medicine. By providing insights into the latest advancements, this review aims to serve as a valuable reference for future research and development in oligopeptide-based therapeutics and skincare innovations.

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生物活性寡肽及其在皮肤再生和嫩肤中的应用。

寡肽是由2-10个氨基酸残基组成的蛋白质片段，具有分子小、生物相容性高、官能团可修饰等独特的结构特征。这些特性赋予寡肽优异的渗透性、安全性和多种生物活性，使其广泛应用于疾病治疗、药物输送和皮肤护理。特别是，寡肽已成为护肤领域的先进成分，通过调节胶原蛋白合成、抗氧化防御和黑色素生成等关键生物过程，具有抗衰老、抗皱和美白效果。本文综述了寡肽及其衍生物的结构、性质、作用机制及其在皮肤再生、嫩肤、抗衰老等方面的应用。通过对最新进展的深入了解，本综述旨在为未来基于寡肽的治疗和护肤创新的研究和开发提供有价值的参考。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Applied Biomaterials & Functional Materials BIOPHYSICS-ENGINEERING, BIOMEDICAL

CiteScore

4.40

自引率

4.00%

发文量

审稿时长

>12 weeks

期刊介绍： The Journal of Applied Biomaterials & Functional Materials (JABFM) is an open access, peer-reviewed, international journal considering the publication of original contributions, reviews and editorials dealing with clinical and laboratory investigations in the fast growing field of biomaterial sciences and functional materials. The areas covered by the journal will include: • Biomaterials / Materials for biomedical applications • Functional materials • Hybrid and composite materials • Soft materials • Hydrogels • Nanomaterials • Gene delivery • Nonodevices • Metamaterials • Active coatings • Surface functionalization • Tissue engineering • Cell delivery/cell encapsulation systems • 3D printing materials • Material characterization • Biomechanics