Najoua Salhi, Otman El Guourrami, Abdelaali Balahbib, Lamiae Rouas, Siham Moussaid, Amina Moutawalli, Fatima Zahra Benkhouili, Mouna Ameggouz, Riaz Ullah, Amal Alotaibi, Abdelhakim Bouyahya, Ching Siang Tan, Long Chiau Ming, My El Abbes Faouzi, Yahya Cherrah
{"title":"应用阿勒颇松提取物治疗皮肤烧伤。","authors":"Najoua Salhi, Otman El Guourrami, Abdelaali Balahbib, Lamiae Rouas, Siham Moussaid, Amina Moutawalli, Fatima Zahra Benkhouili, Mouna Ameggouz, Riaz Ullah, Amal Alotaibi, Abdelhakim Bouyahya, Ching Siang Tan, Long Chiau Ming, My El Abbes Faouzi, Yahya Cherrah","doi":"10.1177/22808000241236020","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>To investigate the <i>Pinus halepensis</i> extracts and determine its healing and antibacterial effects, and to evaluate the treatment of skin burns.</p><p><strong>Methods: </strong>Aqueous and ethanolic extracts and topical based on Aleppo pine plant extracts were prepared. Thirty male and female Wistar rats were used to study the cutaneous toxicity of extracts from the bark of <i>P. halepensis</i>. The extracts' healing potential for burn wounds were also assessed by evaluating the clinical and macroscopic aspects of the wounds. The antibacterial activity of crude extracts of <i>P. halepensis</i> as well as its wound healing abilities was verified in this investigation.</p><p><strong>Results: </strong>In animals with acute dermal toxicity, there were no signs of treatment-related toxicity or death. The extracts of these plants could be transformed into phytomedicines for the treatment of infected wounds. The results demonstrated that formulated ointments are successful in treating second-degree burns in rats and may be suitable for the short-term therapeutic treatment of second-degree burns.</p><p><strong>Conclusion: </strong>This study successfully answered our problem, regarding the efficacy of our extract for treating second-degree burns in rats. Further studies are needed to confirm these results by identifying the molecules responsible for these activities and examining their mechanism of action.</p>","PeriodicalId":14985,"journal":{"name":"Journal of Applied Biomaterials & Functional Materials","volume":null,"pages":null},"PeriodicalIF":3.1000,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Application of Aleppo pine extract for skin burn treatment.\",\"authors\":\"Najoua Salhi, Otman El Guourrami, Abdelaali Balahbib, Lamiae Rouas, Siham Moussaid, Amina Moutawalli, Fatima Zahra Benkhouili, Mouna Ameggouz, Riaz Ullah, Amal Alotaibi, Abdelhakim Bouyahya, Ching Siang Tan, Long Chiau Ming, My El Abbes Faouzi, Yahya Cherrah\",\"doi\":\"10.1177/22808000241236020\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>To investigate the <i>Pinus halepensis</i> extracts and determine its healing and antibacterial effects, and to evaluate the treatment of skin burns.</p><p><strong>Methods: </strong>Aqueous and ethanolic extracts and topical based on Aleppo pine plant extracts were prepared. Thirty male and female Wistar rats were used to study the cutaneous toxicity of extracts from the bark of <i>P. halepensis</i>. The extracts' healing potential for burn wounds were also assessed by evaluating the clinical and macroscopic aspects of the wounds. The antibacterial activity of crude extracts of <i>P. halepensis</i> as well as its wound healing abilities was verified in this investigation.</p><p><strong>Results: </strong>In animals with acute dermal toxicity, there were no signs of treatment-related toxicity or death. The extracts of these plants could be transformed into phytomedicines for the treatment of infected wounds. The results demonstrated that formulated ointments are successful in treating second-degree burns in rats and may be suitable for the short-term therapeutic treatment of second-degree burns.</p><p><strong>Conclusion: </strong>This study successfully answered our problem, regarding the efficacy of our extract for treating second-degree burns in rats. Further studies are needed to confirm these results by identifying the molecules responsible for these activities and examining their mechanism of action.</p>\",\"PeriodicalId\":14985,\"journal\":{\"name\":\"Journal of Applied Biomaterials & Functional Materials\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":3.1000,\"publicationDate\":\"2024-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Applied Biomaterials & Functional Materials\",\"FirstCategoryId\":\"5\",\"ListUrlMain\":\"https://doi.org/10.1177/22808000241236020\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"BIOPHYSICS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Applied Biomaterials & Functional Materials","FirstCategoryId":"5","ListUrlMain":"https://doi.org/10.1177/22808000241236020","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"BIOPHYSICS","Score":null,"Total":0}
Application of Aleppo pine extract for skin burn treatment.
Objective: To investigate the Pinus halepensis extracts and determine its healing and antibacterial effects, and to evaluate the treatment of skin burns.
Methods: Aqueous and ethanolic extracts and topical based on Aleppo pine plant extracts were prepared. Thirty male and female Wistar rats were used to study the cutaneous toxicity of extracts from the bark of P. halepensis. The extracts' healing potential for burn wounds were also assessed by evaluating the clinical and macroscopic aspects of the wounds. The antibacterial activity of crude extracts of P. halepensis as well as its wound healing abilities was verified in this investigation.
Results: In animals with acute dermal toxicity, there were no signs of treatment-related toxicity or death. The extracts of these plants could be transformed into phytomedicines for the treatment of infected wounds. The results demonstrated that formulated ointments are successful in treating second-degree burns in rats and may be suitable for the short-term therapeutic treatment of second-degree burns.
Conclusion: This study successfully answered our problem, regarding the efficacy of our extract for treating second-degree burns in rats. Further studies are needed to confirm these results by identifying the molecules responsible for these activities and examining their mechanism of action.
期刊介绍:
The Journal of Applied Biomaterials & Functional Materials (JABFM) is an open access, peer-reviewed, international journal considering the publication of original contributions, reviews and editorials dealing with clinical and laboratory investigations in the fast growing field of biomaterial sciences and functional materials.
The areas covered by the journal will include:
• Biomaterials / Materials for biomedical applications
• Functional materials
• Hybrid and composite materials
• Soft materials
• Hydrogels
• Nanomaterials
• Gene delivery
• Nonodevices
• Metamaterials
• Active coatings
• Surface functionalization
• Tissue engineering
• Cell delivery/cell encapsulation systems
• 3D printing materials
• Material characterization
• Biomechanics