Veena Wenqing Xu, Iris Xiaoxue Yin, John Yun Niu, Ollie Yiru Yu, Mohammed Zahedul Islam Nizami, Chun-Hung Chu
{"title":"四胺氟化铜的抗菌性能。","authors":"Veena Wenqing Xu, Iris Xiaoxue Yin, John Yun Niu, Ollie Yiru Yu, Mohammed Zahedul Islam Nizami, Chun-Hung Chu","doi":"10.1177/22808000241307803","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>A stable copper tetraamine fluoride (CTF) with low cytotoxicity has been developed for dental use.</p><p><strong>Objective: </strong>To investigate the antimicrobial effects of CTF against common microbes associated with dental caries and periodontal disease.</p><p><strong>Method: </strong>The minimum inhibitory concentrations (MIC) and minimum bactericidal/fungicidal concentrations (MBC/MFC) were used to evaluate the antimicrobial effects of CTF against eight common bacteria and one fungus associated with dental caries and periodontal disease. These nine microbes included cariogenic pathogens (<i>Streptococcus mutans</i>, <i>Streptococcus sobrinus</i>, <i>Lactobacillus acidophilus</i>, <i>Lacticaseibacillus casei</i>, <i>Actinomyces naeslundii</i> and <i>Candida albicans</i>), pulpitis-related bacteria (<i>Enterococcus faecalis</i>) and periodontal disease-related bacteria (<i>Porphyromonas gingivalis</i> and <i>Actinobacillus actinomycetemcomitans</i>). Transmission electron microscopy (TEM) was employed to examine the morphological changes of microbes with and without CTF treatment.</p><p><strong>Results: </strong>The MIC of CTF against nine microbes ranged from 80 ppm (<i>Lacticaseibacillus casei</i>) to 640 ppm (<i>Candida albicans</i> and <i>Enterococcus faecalis</i>). The MBC/MFC ranged from 320 ppm (<i>Lacticaseibacillus casei</i>) to 2560 ppm (<i>Candida albicans</i>). TEM revealed abnormal curvature of cell membranes, disrupted cell membranes, cytoplasmic clear zone, and cytoplasmic content leakage of the microbes treated with CTF.</p><p><strong>Conclusion: </strong>CTF has antimicrobial effects against common oral pathogens and presents a promising antimicrobial agent to aid management of dental caries and periodontal disease.</p>","PeriodicalId":14985,"journal":{"name":"Journal of Applied Biomaterials & Functional Materials","volume":"22 ","pages":"22808000241307803"},"PeriodicalIF":3.1000,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Antimicrobial properties of copper tetraamine fluoride.\",\"authors\":\"Veena Wenqing Xu, Iris Xiaoxue Yin, John Yun Niu, Ollie Yiru Yu, Mohammed Zahedul Islam Nizami, Chun-Hung Chu\",\"doi\":\"10.1177/22808000241307803\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>A stable copper tetraamine fluoride (CTF) with low cytotoxicity has been developed for dental use.</p><p><strong>Objective: </strong>To investigate the antimicrobial effects of CTF against common microbes associated with dental caries and periodontal disease.</p><p><strong>Method: </strong>The minimum inhibitory concentrations (MIC) and minimum bactericidal/fungicidal concentrations (MBC/MFC) were used to evaluate the antimicrobial effects of CTF against eight common bacteria and one fungus associated with dental caries and periodontal disease. These nine microbes included cariogenic pathogens (<i>Streptococcus mutans</i>, <i>Streptococcus sobrinus</i>, <i>Lactobacillus acidophilus</i>, <i>Lacticaseibacillus casei</i>, <i>Actinomyces naeslundii</i> and <i>Candida albicans</i>), pulpitis-related bacteria (<i>Enterococcus faecalis</i>) and periodontal disease-related bacteria (<i>Porphyromonas gingivalis</i> and <i>Actinobacillus actinomycetemcomitans</i>). Transmission electron microscopy (TEM) was employed to examine the morphological changes of microbes with and without CTF treatment.</p><p><strong>Results: </strong>The MIC of CTF against nine microbes ranged from 80 ppm (<i>Lacticaseibacillus casei</i>) to 640 ppm (<i>Candida albicans</i> and <i>Enterococcus faecalis</i>). The MBC/MFC ranged from 320 ppm (<i>Lacticaseibacillus casei</i>) to 2560 ppm (<i>Candida albicans</i>). TEM revealed abnormal curvature of cell membranes, disrupted cell membranes, cytoplasmic clear zone, and cytoplasmic content leakage of the microbes treated with CTF.</p><p><strong>Conclusion: </strong>CTF has antimicrobial effects against common oral pathogens and presents a promising antimicrobial agent to aid management of dental caries and periodontal disease.</p>\",\"PeriodicalId\":14985,\"journal\":{\"name\":\"Journal of Applied Biomaterials & Functional Materials\",\"volume\":\"22 \",\"pages\":\"22808000241307803\"},\"PeriodicalIF\":3.1000,\"publicationDate\":\"2024-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Applied Biomaterials & Functional Materials\",\"FirstCategoryId\":\"5\",\"ListUrlMain\":\"https://doi.org/10.1177/22808000241307803\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"BIOPHYSICS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Applied Biomaterials & Functional Materials","FirstCategoryId":"5","ListUrlMain":"https://doi.org/10.1177/22808000241307803","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"BIOPHYSICS","Score":null,"Total":0}
Antimicrobial properties of copper tetraamine fluoride.
Background: A stable copper tetraamine fluoride (CTF) with low cytotoxicity has been developed for dental use.
Objective: To investigate the antimicrobial effects of CTF against common microbes associated with dental caries and periodontal disease.
Method: The minimum inhibitory concentrations (MIC) and minimum bactericidal/fungicidal concentrations (MBC/MFC) were used to evaluate the antimicrobial effects of CTF against eight common bacteria and one fungus associated with dental caries and periodontal disease. These nine microbes included cariogenic pathogens (Streptococcus mutans, Streptococcus sobrinus, Lactobacillus acidophilus, Lacticaseibacillus casei, Actinomyces naeslundii and Candida albicans), pulpitis-related bacteria (Enterococcus faecalis) and periodontal disease-related bacteria (Porphyromonas gingivalis and Actinobacillus actinomycetemcomitans). Transmission electron microscopy (TEM) was employed to examine the morphological changes of microbes with and without CTF treatment.
Results: The MIC of CTF against nine microbes ranged from 80 ppm (Lacticaseibacillus casei) to 640 ppm (Candida albicans and Enterococcus faecalis). The MBC/MFC ranged from 320 ppm (Lacticaseibacillus casei) to 2560 ppm (Candida albicans). TEM revealed abnormal curvature of cell membranes, disrupted cell membranes, cytoplasmic clear zone, and cytoplasmic content leakage of the microbes treated with CTF.
Conclusion: CTF has antimicrobial effects against common oral pathogens and presents a promising antimicrobial agent to aid management of dental caries and periodontal disease.
期刊介绍：
The Journal of Applied Biomaterials & Functional Materials (JABFM) is an open access, peer-reviewed, international journal considering the publication of original contributions, reviews and editorials dealing with clinical and laboratory investigations in the fast growing field of biomaterial sciences and functional materials.
The areas covered by the journal will include:
• Biomaterials / Materials for biomedical applications
• Functional materials
• Hybrid and composite materials
• Soft materials
• Hydrogels
• Nanomaterials
• Gene delivery
• Nonodevices
• Metamaterials
• Active coatings
• Surface functionalization
• Tissue engineering
• Cell delivery/cell encapsulation systems
• 3D printing materials
• Material characterization
• Biomechanics
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