International review of neurobiology最新文献_第6页

Peri-adolescent exposure to (meth)amphetamine in animal models. 在动物模型中，青春期前后暴露于（冰毒）安非他明。

3区医学

International review of neurobiology Pub Date : 2022-01-01 Epub Date: 2021-08-20 DOI: 10.1016/bs.irn.2021.06.011

T J Phillips, S J Aldrich

{"title":"Peri-adolescent exposure to (meth)amphetamine in animal models.","authors":"T J Phillips, S J Aldrich","doi":"10.1016/bs.irn.2021.06.011","DOIUrl":"10.1016/bs.irn.2021.06.011","url":null,"abstract":"Experimentation with psychoactive drugs is often initiated in the peri-adolescent period, but knowledge of differences in the outcomes of peri-adolescent- vs adult-initiated exposure is incomplete. We consider the existing animal research in this area for (meth)amphetamines. Established for a number of phenotypes, is lower sensitivity of peri-adolescents than adults to acute effects of (meth)amphetamines, including neurotoxic effects of binge-level exposure. More variable are data for long-term consequences of peri-adolescent exposure on motivational and cognitive traits. Moreover, investigations often exclude an adult-initiated exposure group critical for answering questions about outcomes unique to peri-adolescent initiation. Despite this, it is clear from the animal research that (meth)amphetamine exposure during the peri-adolescent period, whether self- or other-administered, impacts brain motivational circuitry and cognitive function, and alters adult sensitivity to other drugs and natural rewards. Such consequences occurring in humans have the potential to predispose toward unfortunate and potentially disastrous family, social and livelihood outcomes.","PeriodicalId":14468,"journal":{"name":"International review of neurobiology","volume":"161 ","pages":"1-51"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9134876/pdf/nihms-1809733.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39641097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cell transplantation to repair the injured spinal cord. 细胞移植修复损伤的脊髓。

3区医学

International review of neurobiology Pub Date : 2022-01-01 Epub Date: 2022-11-09 DOI: 10.1016/bs.irn.2022.09.008

Adam Hall, Tara Fortino, Victoria Spruance, Alessia Niceforo, James S Harrop, Patricia E Phelps, Catherine A Priest, Lyandysha V Zholudeva, Michael A Lane

引用次数: 0

Sex and gender differences in dementia. 痴呆症的性别差异。

3区医学

International review of neurobiology Pub Date : 2022-01-01 Epub Date: 2022-08-02 DOI: 10.1016/bs.irn.2022.07.002

Patrick Salwierz, Carly Davenport, Vishaal Sumra, M Florencia Iulita, Maria Teresa Ferretti, Maria Carmela Tartaglia

{"title":"Sex and gender differences in dementia.","authors":"Patrick Salwierz, Carly Davenport, Vishaal Sumra, M Florencia Iulita, Maria Teresa Ferretti, Maria Carmela Tartaglia","doi":"10.1016/bs.irn.2022.07.002","DOIUrl":"https://doi.org/10.1016/bs.irn.2022.07.002","url":null,"abstract":"The dementia landscape has undergone a striking paradigm shift. The advances in understanding of neurodegeneration and proteinopathies has changed our approach to patients with cognitive impairment. Firstly, it has recently been shown that the various proteinopathies that are the cause of the dementia begin to build up long before the appearance of any obvious symptoms. This has cemented the idea that there is an urgency in diagnosis as it occurs very late in the pathophysiology of these diseases. Secondly, that accurate diagnosis is required to deliver targeted therapies, that is precision medicine. With this latter point, the realization that various factors of a person need to be considered as they may impact the presentation and progression of disease has risen to the forefront. Two of these factors aside from race and age are biological sex and gender (social construct), as both can have tremendous impact on manifestation of disease. This chapter will cover what is known and remains to be known on the interaction of sex and gender with some of the major causes of dementia.","PeriodicalId":14468,"journal":{"name":"International review of neurobiology","volume":"164 ","pages":"179-233"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33445989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Biological underpinnings of sex differences in neurological disorders. 神经疾病中性别差异的生物学基础。

3区医学

International review of neurobiology Pub Date : 2022-01-01 Epub Date: 2022-07-30 DOI: 10.1016/bs.irn.2022.06.009

Katarzyna Winek, Yonat Tzur, Hermona Soreq

引用次数: 0

Intersections of the microbiome and early neurodevelopment. 微生物组与早期神经发育的交叉。

3区医学

International review of neurobiology Pub Date : 2022-01-01 DOI: 10.1016/bs.irn.2022.06.004

Helen E Vuong

{"title":"Intersections of the microbiome and early neurodevelopment.","authors":"Helen E Vuong","doi":"10.1016/bs.irn.2022.06.004","DOIUrl":"https://doi.org/10.1016/bs.irn.2022.06.004","url":null,"abstract":"Our resident microbes influence nearly all aspects of our biological systems. In particular, the maternal and early life microbiota is uniquely positioned to influence the development of the nervous system, and alterations to the gut microbiota, or dysbiosis, during this critical time in early life can have long-lasting negative effects on health. The question of how the maternal and early life microbiota shapes neurodevelopment is the topic of numerous investigations. Here, we discuss two possible, but not necessarily independent, hypotheses: (1) the maternal microbiota during pregnancy regulates the metabolites that are important for fetal development, (2) maternal microbiota seeded to offspring at birth and early postnatal days programs offspring immune and brain development, and regulates key molecules for postnatal brain development. In this chapter, we provide an overview of the impact of the microbiota on brain and behavior, introduce the maternal gut and vaginal microbiome during pregnancy, and discuss current understandings of microbiome in the context of developmental origins of health and disease. We consider novel translational insights that harness the multitude of microbes and microbial metabolites for prevention or treatment of neurological disorders.","PeriodicalId":14468,"journal":{"name":"International review of neurobiology","volume":"167 ","pages":"1-23"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10502051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

The many genomes of Parkinson's disease. 帕金森氏症的许多基因组。

3区医学

International review of neurobiology Pub Date : 2022-01-01 Epub Date: 2022-08-11 DOI: 10.1016/bs.irn.2022.07.007

Haydeh Payami

引用次数: 0

Does essential tremor increase the risk of dementia? No. 特发性震颤会增加患痴呆的风险吗?不。

3区医学

International review of neurobiology Pub Date : 2022-01-01 Epub Date: 2022-03-31 DOI: 10.1016/bs.irn.2022.02.012

Alex Rajput

{"title":"Does essential tremor increase the risk of dementia? No.","authors":"Alex Rajput","doi":"10.1016/bs.irn.2022.02.012","DOIUrl":"https://doi.org/10.1016/bs.irn.2022.02.012","url":null,"abstract":"Essential tremor (ET) is the most common neurological cause of tremor affecting adult humans affecting about 6% of those over age 65 years. In the United States, dementia has a prevalence of 15% in those age 68 and older. Overlap of the two conditions is therefore not surprising. Several studies report mild subclinical cognitive dysfunction in non-demented people with ET, likely related to overactivity of fronto-cerebellar circuitry involved in tremor pathophysiology. Frontal/executive dysfunction is often though not exclusively noted, and some studies have even shown areas of cognitive strengths. Mild cognitive impairment (MCI) is impairment which a person is aware of but does not interfere significantly with daily activities. While MCI has been considered to presage dementia this is not necessarily the case, as some persons with MCI revert to normal cognition in follow-up. Dementia is a clinical syndrome with cognitive impairment interfering with daily activities. Population-based and clinic-based studies have shown mixed results regarding rates of MCI in ET. A handful of studies have looked at development of dementia in ET with differing results. Brain pathology studies in ET and dementia or investigating Alzheimer-type pathology have thus far been unrevealing. There is evidence by some investigators supporting a greater risk of dementia for those having older onset tremor, while those having ET at a younger age faring at least as well as controls regarding risk of cognitive impairment and dementia. At present the evidence is inconclusive that ET as a group are at a greater risk of developing dementia.","PeriodicalId":14468,"journal":{"name":"International review of neurobiology","volume":" ","pages":"233-253"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40396048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

The impact of nonmotor symptom burden on sexual function. 非运动症状负担对性功能的影响。

3区医学

International review of neurobiology Pub Date : 2022-01-01 DOI: 10.1016/bs.irn.2021.12.007

J. Staunton, S. Jost, Gilla Bronner, K. Chaudhuri

引用次数: 1

Introduction. 介绍。

3区医学

International review of neurobiology Pub Date : 2022-01-01 DOI: 10.1016/S0074-7742(22)00089-7

E. Moro, G. Arabia, M. Tartaglia, M. Ferretti

引用次数: 0

Spotlight on non-motor symptoms and Covid-19. 聚焦非运动症状和 Covid-19。

3区医学

International review of neurobiology Pub Date : 2022-01-01 Epub Date: 2022-07-09 DOI: 10.1016/bs.irn.2022.04.001

Silvia Rota, Iro Boura, Yi-Min Wan, Claudia Lazcano-Ocampo, Mayela Rodriguez-Violante, Angelo Antonini, Kallol Ray Chaudhuri

{"title":"Spotlight on non-motor symptoms and Covid-19.","authors":"Silvia Rota, Iro Boura, Yi-Min Wan, Claudia Lazcano-Ocampo, Mayela Rodriguez-Violante, Angelo Antonini, Kallol Ray Chaudhuri","doi":"10.1016/bs.irn.2022.04.001","DOIUrl":"10.1016/bs.irn.2022.04.001","url":null,"abstract":"The Coronavirus Disease 2019 (Covid-19) pandemic has profoundly affected the quality of life (QoL) and health of the general population globally over the past 2 years, with a clear impact on people with Parkinson's Disease (PwP, PD). Non-motor symptoms have been widely acknowledged to hold a vital part in the clinical spectrum of PD, and, although often underrecognized, they significantly contribute to patients' and their caregivers' QoL. Up to now, there have been numerous reports of newly emerging or acutely deteriorating non-motor symptoms in PwP who had been infected by the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2), while some of these symptoms, like fatigue, pain, depression, anxiety and cognitive impairment, have also been identified as part of the long-COVID syndrome due to their persistent nature. The subjacent mechanisms, mediating the appearance or progression of non-motor symptoms in the context of Covid-19, although probably multifactorial in origin, remain largely unknown. Such mechanisms might be, at least partly, related solely to the viral infection per se or the lifestyle changes imposed during the pandemic, as many of the non-motor symptoms seem to be prevalent even among Covid-19 patients without PD. Here, we summarize the available evidence and implications of Covid-19 in non-motor PD symptoms in the acute and chronic, if applicable, phase of the infection, with a special reference on studies of PwP.","PeriodicalId":14468,"journal":{"name":"International review of neurobiology","volume":" ","pages":"103-133"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9270874/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33493599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0